BLASTX 7.6.2
Query= UN24426 /QuerySize=1063
(1062 letters)
Database: UniProt/SwissProt;
518,415 sequences; 182,829,261 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q86KI1|AP2A2_DICDI AP-2 complex subunit alpha-2 OS=Dictyostel... 144 2e-033
sp|P91926|AP2A_DROME AP-2 complex subunit alpha OS=Drosophila me... 124 1e-027
sp|Q29N38|AP2A_DROPS AP-2 complex subunit alpha OS=Drosophila ps... 124 2e-027
sp|P18484|AP2A2_RAT AP-2 complex subunit alpha-2 OS=Rattus norve... 116 4e-025
sp|Q0VCK5|AP2A2_BOVIN AP-2 complex subunit alpha-2 OS=Bos taurus... 115 6e-025
sp|P17427|AP2A2_MOUSE AP-2 complex subunit alpha-2 OS=Mus muscul... 114 1e-024
sp|O94973|AP2A2_HUMAN AP-2 complex subunit alpha-2 OS=Homo sapie... 111 1e-023
sp|Q7QG73|AP2A_ANOGA AP-2 complex subunit alpha OS=Anopheles gam... 106 3e-022
sp|P17426|AP2A1_MOUSE AP-2 complex subunit alpha-1 OS=Mus muscul... 104 1e-021
sp|O95782|AP2A1_HUMAN AP-2 complex subunit alpha-1 OS=Homo sapie... 104 2e-021
sp|Q9C0W7|AP2A_SCHPO AP-2 complex subunit alpha OS=Schizosacchar... 78 8e-014
>sp|Q86KI1|AP2A2_DICDI AP-2 complex subunit alpha-2 OS=Dictyostelium discoideum
GN=ap2a1-1 PE=3 SV=1
Length = 989
Score = 144 bits (361), Expect = 2e-033
Identities = 78/234 (33%), Positives = 128/234 (54%), Gaps = 3/234 (1%)
Frame = +3
Query: 6 FHALCLKDSGVLYEDPYIQIGIKAEWRGHHGRLVLFLGNKSTSPLTSVQALILPPAHLKL 185
+ LCL GVLYED +Q+G+K+E++ GRL+L+ GN S PLT+ + A L L
Sbjct: 756 YKRLCLVSEGVLYEDSMLQVGLKSEYQSGQGRLMLYYGNSSAFPLTNFNVTLNSIAGLTL 815
Query: 186 ELSPVPDTIPPRAQVQSPLEVMNIRPSRDVAVLDFSYKLGTIVVGAKLRIPAVINKFLQP 365
+ + I P+AQ+Q P+ + V+ ++ + LR+P VI+KF +P
Sbjct: 816 QPQSIAPVIQPKAQLQQPVTFSCTSEFTESPVITINFLTPGKPITITLRLPIVISKFFEP 875
Query: 366 LQLTTEEFFPQWRALSGPPLKLQEVVRGVRPLALPEMANLF-NSFRVTICPGLDPNPNNL 542
L+L++ +FF +W+ +SG PL++QE+ + +P+ + + +T+ +DPNPNN+
Sbjct: 876 LRLSSGDFFARWKTISGKPLEIQEIFKSTKPIDIQSYNRVIQEGLNITVLKQVDPNPNNI 935
Query: 543 VASTTFYSDTTGAML-CLARIETDPADRTQLRMTVGSGDPTLTFELKEFIKEQL 701
VAS F + G + RIET+P R+T+ S TLT +K + L
Sbjct: 936 VASCLFPFGSNGQPINSYIRIETNP-QANMCRLTIRSQSATLTNTIKNLLISHL 988
>sp|P91926|AP2A_DROME AP-2 complex subunit alpha OS=Drosophila melanogaster
GN=alpha-Adaptin PE=1 SV=1
Length = 940
Score = 124 bits (310), Expect = 1e-027
Identities = 72/230 (31%), Positives = 127/230 (55%), Gaps = 8/230 (3%)
Frame = +3
Query: 24 KDSGVLYEDPYIQIGIKAEWRGHHGRLVLFLGNKSTSPLTSVQALILPPAH----LKLEL 191
K++GVL+E+ +QIG+K+E+R + GRL LF GNK+ PLT+ ++ A L +++
Sbjct: 713 KNNGVLFENEMLQIGVKSEFRQNLGRLGLFYGNKTQVPLTNFNPVLQWSAEDALKLNVQM 772
Query: 192 SPVPDTIPPRAQVQSPLEVMNIRPSRDVAVLDFSYKLGTIVVGAKLRIPAVINKFLQPLQ 371
V T+ AQ+Q L I D ++ S++ +++P +NKF +P +
Sbjct: 773 KVVEPTLEAGAQIQQLLTAECIEDYADAPTIEISFRYNGTQQKFSIKLPLSVNKFFEPTE 832
Query: 372 LTTEEFFPQWRALSGPPLKLQEVVRGVRPLALPEMANLFNSFRVTICPGLDPNPNNLVAS 551
+ E FF +W+ LSG + Q+V + +PL LP N F + + +DPNP+N+V +
Sbjct: 833 MNAESFFARWKNLSGEQQRSQKVFKAAQPLDLPGARNKLMGFGMQLLDQVDPNPDNMVCA 892
Query: 552 TTFYSDTTGAMLCLARIETDPADRTQL-RMTVGSGDPTLTFELKEFIKEQ 698
++ + + CL R+E P + Q+ R+TV + T+T E+ + + +Q
Sbjct: 893 GIIHTQSQ-QVGCLMRLE--PNKQAQMFRLTVRASKETVTREICDLLTDQ 939
>sp|Q29N38|AP2A_DROPS AP-2 complex subunit alpha OS=Drosophila pseudoobscura
pseudoobscura GN=alpha-Adaptin PE=3 SV=1
Length = 939
Score = 124 bits (309), Expect = 2e-027
Identities = 71/230 (30%), Positives = 127/230 (55%), Gaps = 8/230 (3%)
Frame = +3
Query: 24 KDSGVLYEDPYIQIGIKAEWRGHHGRLVLFLGNKSTSPLTSVQALILPPAH----LKLEL 191
K++GVL+E+ +QIG+K+E+R + GRL LF GNK+ PL++ ++ A L +++
Sbjct: 712 KNNGVLFENEMLQIGVKSEFRQNLGRLGLFYGNKTQVPLSNFNPVLQWSAEETLKLNVQM 771
Query: 192 SPVPDTIPPRAQVQSPLEVMNIRPSRDVAVLDFSYKLGTIVVGAKLRIPAVINKFLQPLQ 371
V T+ AQ+Q L I D ++ S++ +++P +NKF +P +
Sbjct: 772 KAVEPTLEAGAQIQQLLTAECIEDYADAPTIEISFRYNGTQQKFSIKLPLSVNKFFEPTE 831
Query: 372 LTTEEFFPQWRALSGPPLKLQEVVRGVRPLALPEMANLFNSFRVTICPGLDPNPNNLVAS 551
+ E FF +W+ LSG + Q+V + +PL LP N F + + +DPNP+N+V +
Sbjct: 832 MNAESFFARWKNLSGEQQRSQKVFKAAQPLDLPGARNKLMGFGMQLLDSVDPNPDNMVCA 891
Query: 552 TTFYSDTTGAMLCLARIETDPADRTQL-RMTVGSGDPTLTFELKEFIKEQ 698
++ + + CL R+E P + Q+ R+TV + T+T E+ + + +Q
Sbjct: 892 GIIHTQSQ-QVGCLMRLE--PNKQAQMFRLTVRASKETVTREICDLLADQ 938
>sp|P18484|AP2A2_RAT AP-2 complex subunit alpha-2 OS=Rattus norvegicus GN=Ap2a2
PE=1 SV=3
Length = 938
Score = 116 bits (289), Expect = 4e-025
Identities = 69/229 (30%), Positives = 119/229 (51%), Gaps = 6/229 (2%)
Frame = +3
Query: 24 KDSGVLYEDPYIQIGIKAEWRGHHGRLVLFLGNK-STSPLTSVQALILP---PAHLKLEL 191
K++GVL+E+ +QIG+K+E+R + GR+ +F GNK ST L LI +L L+
Sbjct: 711 KNNGVLFENQLLQIGLKSEFRQNLGRMFIFYGNKTSTQFLNFTPTLICADDLQTNLNLQT 770
Query: 192 SPVPDTIPPRAQVQSPLEVMNIRPSRDVAVLDFSYKLGTIVVGAKLRIPAVINKFLQPLQ 371
PV T+ AQVQ + + I + VL+ ++ G +++P +NKF QP +
Sbjct: 771 KPVDPTVDGGAQVQQVINIECISDFTEAPVLNIQFRYGGTFQNVSVKLPITLNKFFQPTE 830
Query: 372 LTTEEFFPQWRALSGPPLKLQEVVRGVRPLALPEMANLFNSFRVTICPGLDPNPNNLVAS 551
+ +++FF +W+ LS P ++Q + + P+ F + +DPNP N V +
Sbjct: 831 MASQDFFQRWKQLSNPQQEVQNIFKAKHPMDTEITKAKIIGFGSALLEEVDPNPANFVGA 890
Query: 552 TTFYSDTTGAMLCLARIETDPADRTQLRMTVGSGDPTLTFELKEFIKEQ 698
++ TT + CL R+E + R+T+ + T++ L E + EQ
Sbjct: 891 GIIHTKTT-QIGCLLRLEPN-LQAQMYRLTLRTSKDTVSQRLCELLSEQ 937
>sp|Q0VCK5|AP2A2_BOVIN AP-2 complex subunit alpha-2 OS=Bos taurus GN=AP2A2 PE=1
SV=1
Length = 938
Score = 115 bits (287), Expect = 6e-025
Identities = 68/229 (29%), Positives = 119/229 (51%), Gaps = 6/229 (2%)
Frame = +3
Query: 24 KDSGVLYEDPYIQIGIKAEWRGHHGRLVLFLGNK-STSPLTSVQALILP---PAHLKLEL 191
K++GVL+E+ +QIG+K+E+R + GR+ +F GNK ST L LI A+L L+
Sbjct: 711 KNNGVLFENQLLQIGLKSEFRQNLGRMFIFYGNKTSTQFLNFTPTLICSDDLQANLSLQT 770
Query: 192 SPVPDTIPPRAQVQSPLEVMNIRPSRDVAVLDFSYKLGTIVVGAKLRIPAVINKFLQPLQ 371
PV T+ AQVQ + + + + VL+ ++ G +++P +NKF QP +
Sbjct: 771 KPVDPTVDGGAQVQQAVNIECVSDFTEAPVLNIQFRYGGTFQNVSVKLPITLNKFFQPTE 830
Query: 372 LTTEEFFPQWRALSGPPLKLQEVVRGVRPLALPEMANLFNSFRVTICPGLDPNPNNLVAS 551
+ +++FF +W+ LS P ++Q + + P+ F + +DPNP N V +
Sbjct: 831 MASQDFFQRWKQLSNPQQEVQSIFKAKHPMDTEVTKAKIIGFGSALLEEVDPNPANFVGA 890
Query: 552 TTFYSDTTGAMLCLARIETDPADRTQLRMTVGSGDPTLTFELKEFIKEQ 698
++ T + CL R+E + R+T+ + T++ L E + EQ
Sbjct: 891 GIIHT-RTAQIGCLLRLEPN-LQAQMYRLTLRTSRETVSQRLCELLSEQ 937
>sp|P17427|AP2A2_MOUSE AP-2 complex subunit alpha-2 OS=Mus musculus GN=Ap2a2
PE=1 SV=1
Length = 938
Score = 114 bits (285), Expect = 1e-024
Identities = 69/229 (30%), Positives = 118/229 (51%), Gaps = 6/229 (2%)
Frame = +3
Query: 24 KDSGVLYEDPYIQIGIKAEWRGHHGRLVLFLGNK-STSPLTSVQALILP---PAHLKLEL 191
K++GVL+E+ +QIG+K+E+R + GR+ +F GNK ST L LI +L L+
Sbjct: 711 KNNGVLFENQLLQIGLKSEFRQNLGRMFIFYGNKTSTQFLNFTPTLICADDLQTNLNLQT 770
Query: 192 SPVPDTIPPRAQVQSPLEVMNIRPSRDVAVLDFSYKLGTIVVGAKLRIPAVINKFLQPLQ 371
PV T+ AQVQ + + I + VL+ ++ G +++P +NKF QP +
Sbjct: 771 KPVDPTVDGGAQVQQVVNIECISDFTEAPVLNIQFRYGGTFQNVSVKLPITLNKFFQPTE 830
Query: 372 LTTEEFFPQWRALSGPPLKLQEVVRGVRPLALPEMANLFNSFRVTICPGLDPNPNNLVAS 551
+ +++FF +W+ LS P ++Q + + P+ F + +DPNP N V
Sbjct: 831 MASQDFFQRWKQLSNPQQEVQNIFKAKHPMDTEITKAKIIGFGSALLEEVDPNPANFVVL 890
Query: 552 TTFYSDTTGAMLCLARIETDPADRTQLRMTVGSGDPTLTFELKEFIKEQ 698
++ TT + CL R+E + R+T+ + T++ L E + EQ
Sbjct: 891 GIIHTKTT-QIGCLLRLEPN-LQAQMYRLTLRTSKDTVSQRLCELLSEQ 937
>sp|O94973|AP2A2_HUMAN AP-2 complex subunit alpha-2 OS=Homo sapiens GN=AP2A2
PE=1 SV=2
Length = 939
Score = 111 bits (276), Expect = 1e-023
Identities = 68/230 (29%), Positives = 119/230 (51%), Gaps = 8/230 (3%)
Frame = +3
Query: 24 KDSGVLYEDPYIQIGIKAEWRGHHGRLVLFLGNK-STSPLTSVQALI----LPPAHLKLE 188
K++GVL+E+ +QIG+K+E+R + GR+ +F GNK ST L LI L P +L L+
Sbjct: 712 KNNGVLFENQLLQIGLKSEFRQNLGRMFIFYGNKTSTQFLNFTPTLICSDDLQP-NLNLQ 770
Query: 189 LSPVPDTIPPRAQVQSPLEVMNIRPSRDVAVLDFSYKLGTIVVGAKLRIPAVINKFLQPL 368
PV T+ AQVQ + + + + VL+ ++ G +++P +NKF QP
Sbjct: 771 TKPVDPTVEGGAQVQQVVNIECVSDFTEAPVLNIQFRYGGTFQNVSVQLPITLNKFFQPT 830
Query: 369 QLTTEEFFPQWRALSGPPLKLQEVVRGVRPLALPEMANLFNSFRVTICPGLDPNPNNLVA 548
++ +++FF +W+ LS P ++Q + + P+ F + +DPNP N V
Sbjct: 831 EMASQDFFQRWKQLSNPQQEVQNIFKAKHPMDTEVTKAKIIGFGSALLEEVDPNPANFVG 890
Query: 549 STTFYSDTTGAMLCLARIETDPADRTQLRMTVGSGDPTLTFELKEFIKEQ 698
+ ++ TT + CL R+E + R+T+ + ++ L E + Q
Sbjct: 891 AGIIHTKTT-QIGCLLRLEPN-LQAQMYRLTLRTSKEAVSQRLCELLSAQ 938
>sp|Q7QG73|AP2A_ANOGA AP-2 complex subunit alpha OS=Anopheles gambiae
GN=alpha-Adaptin PE=3 SV=4
Length = 934
Score = 106 bits (264), Expect = 3e-022
Identities = 69/231 (29%), Positives = 120/231 (51%), Gaps = 9/231 (3%)
Frame = +3
Query: 24 KDSGVLYEDPYIQIGIKAEWRGHHGRLVLFLGNKSTSPLTSVQALILPPAH----LKLEL 191
K++GVL+E+ +QIG+K+E+R + GRL L+ GNK+ + L + + A L +++
Sbjct: 706 KNNGVLFENDLLQIGVKSEFRQNLGRLGLYYGNKTQTALQNFVPTLQWSAEDALKLNVQI 765
Query: 192 SPVPDTIPPRAQVQSPLEVMNIRPSRDVAVLDFSYKL-GTIVVGAKLRIPAVINKFLQPL 368
V T+ AQ+Q L I + S+++ G + +P INKF +P
Sbjct: 766 KAVEPTLEAGAQIQQLLTAECIDHYLGAPSIVISFRVSGGAPQKITVNLPLTINKFFEPT 825
Query: 369 QLTTEEFFPQWRALSGPPLKLQEVVRGVRPLALPEMANLFNSFRVTICPGLDPNPNNLVA 548
++ E FF +WR L G + Q V + +PL LP N F + + +DPNP+N+V
Sbjct: 826 EMNAESFFARWRNLGGEQQRAQRVFKAQQPLDLPGARNKLTGFGMQLLDSIDPNPDNMVC 885
Query: 549 STTFYSDTTGAMLCLARIETDPADRTQL-RMTVGSGDPTLTFELKEFIKEQ 698
+ ++ + CL R+E P + Q+ R+T+ S +T E+ + + +Q
Sbjct: 886 AGIIHTQ-AHKVGCLLRLE--PNKQAQMFRLTIRSSLEAVTQEICDLLVDQ 933
>sp|P17426|AP2A1_MOUSE AP-2 complex subunit alpha-1 OS=Mus musculus GN=Ap2a1
PE=1 SV=1
Length = 977
Score = 104 bits (258), Expect = 1e-021
Identities = 64/229 (27%), Positives = 114/229 (49%), Gaps = 6/229 (2%)
Frame = +3
Query: 24 KDSGVLYEDPYIQIGIKAEWRGHHGRLVLFLGNKSTSPLTSVQALILPPAHLKLELS--- 194
K+SGVL+E+ +QIG+K+E+R + GR+ LF GNK++ + ++ P L+ +L+
Sbjct: 750 KNSGVLFENQLLQIGVKSEFRQNLGRMYLFYGNKTSVQFQNFLPTVVHPGDLQTQLAVQT 809
Query: 195 -PVPDTIPPRAQVQSPLEVMNIRPSRDVAVLDFSYKLGTIVVGAKLRIPAVINKFLQPLQ 371
V + AQVQ L + +R +L ++ G L++P INKF QP +
Sbjct: 810 KRVAAQVDGGAQVQQVLNIECLRDFLTPPLLSVRFRYGGTAQSLTLKLPVTINKFFQPTE 869
Query: 372 LTTEEFFPQWRALSGPPLKLQEVVRGVRPLALPEMANLFNSFRVTICPGLDPNPNNLVAS 551
+ ++FF +W+ LS P + Q++ + P+ F + +DPNP N V +
Sbjct: 870 MAAQDFFQRWKQLSLPLQEAQKIFKANHPMDAEVTKAKLLGFGSALLDNVDPNPENFVGA 929
Query: 552 TTFYSDTTGAMLCLARIETDPADRTQLRMTVGSGDPTLTFELKEFIKEQ 698
+ + CL R+E + A R+T+ + ++ L E + +Q
Sbjct: 930 GIIQTKAL-QVGCLLRLEPN-AQAQMYRLTLRTSKEPVSRHLCELLAQQ 976
>sp|O95782|AP2A1_HUMAN AP-2 complex subunit alpha-1 OS=Homo sapiens GN=AP2A1
PE=1 SV=3
Length = 977
Score = 104 bits (257), Expect = 2e-021
Identities = 63/229 (27%), Positives = 114/229 (49%), Gaps = 6/229 (2%)
Frame = +3
Query: 24 KDSGVLYEDPYIQIGIKAEWRGHHGRLVLFLGNKSTSPLTSVQALILPPAHLKLELS--- 194
K++GVL+E+ +QIG+K+E+R + GR+ LF GNK++ + ++ P L+ +L+
Sbjct: 750 KNNGVLFENQLLQIGVKSEFRQNLGRMYLFYGNKTSVQFQNFSPTVVHPGDLQTQLAVQT 809
Query: 195 -PVPDTIPPRAQVQSPLEVMNIRPSRDVAVLDFSYKLGTIVVGAKLRIPAVINKFLQPLQ 371
V + AQVQ L + +R +L ++ G L++P INKF QP +
Sbjct: 810 KRVAAQVDGGAQVQQVLNIECLRDFLTPPLLSVRFRYGGAPQALTLKLPVTINKFFQPTE 869
Query: 372 LTTEEFFPQWRALSGPPLKLQEVVRGVRPLALPEMANLFNSFRVTICPGLDPNPNNLVAS 551
+ ++FF +W+ LS P + Q++ + P+ F + +DPNP N V +
Sbjct: 870 MAAQDFFQRWKQLSLPQQEAQKIFKANHPMDAEVTKAKLLGFGSALLDNVDPNPENFVGA 929
Query: 552 TTFYSDTTGAMLCLARIETDPADRTQLRMTVGSGDPTLTFELKEFIKEQ 698
+ + CL R+E + A R+T+ + ++ L E + +Q
Sbjct: 930 GIIQTKAL-QVGCLLRLEPN-AQAQMYRLTLRTSKEPVSRHLCELLAQQ 976
>sp|Q9C0W7|AP2A_SCHPO AP-2 complex subunit alpha OS=Schizosaccharomyces pombe
GN=apl3 PE=2 SV=1
Length = 878
Score = 78 bits (191), Expect = 8e-014
Identities = 58/237 (24%), Positives = 111/237 (46%), Gaps = 12/237 (5%)
Frame = +3
Query: 6 FHALCLKDSGVLYEDPYIQIGIKAEWRGHHGRLVLFLGNKSTSPLTSVQALILPPAHLKL 185
F+ LC KD G+LY+D IQIG+++E+ G + L+ N+ ++ L S+ + ++
Sbjct: 643 FYRLCWKDKGILYQDSQIQIGVRSEYHNSEGAIYLYYENRQSNTLKSLSSTLIRTFSTFH 702
Query: 186 ELSPVPDT-IPPRAQVQSPLEVMNIRPSRDVAVLDFSYKLGTIVVGAKLRIPAVINKFLQ 362
+ DT +P Q+Q + + + ++ SY G ++ L++P +++KF++
Sbjct: 703 LATTFQDTNLPSGVQLQQKYVMSGVNEIFEPPIIHVSYVTG-VIRSIDLQLPVLLSKFMK 761
Query: 363 PLQLTTEEFFPQWRALSGPPLKLQEVVRGV----RPLALPEMANLFNSFRVTICPGLDPN 530
P + +FF W + + ++ G+ R L + + + F IC +D
Sbjct: 762 PTIFDSYDFFNHWGQMGVE--REAQLTFGLNSKDRKLDAKRLTKIVSGFHWGICQNVDSI 819
Query: 531 PNNLVASTTFYSDTTGAMLCLARIETDPAD---RTQLRMTVGSGDPTLTFELKEFIK 692
N+V + T + CL RIE + R +R T S TL E++E ++
Sbjct: 820 ALNIVGAGIIRFGTQN-VGCLLRIEPNYEQNLIRLSIRSTNTSIANTLAKEMQEILR 875
Database: UniProt/SwissProt
Posted date: Sat Aug 07 14:36:18 2010
Number of letters in database: 182,829,261
Number of sequences in database: 518,415
Lambda K H
0.267 0.041 0.140
Gapped
Lambda K H
0.267 0.041 0.140
Matrix: blosum62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 102,745,191,639
Number of Sequences: 518415
Number of Extensions: 102745191639
Number of Successful Extensions: 656160410
Number of sequences better than 0.0: 0
|
