BLASTX 7.6.2
Query= UN25192 /QuerySize=1778
(1777 letters)
Database: UniProt/SwissProt;
518,415 sequences; 182,829,261 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q5R5R2|HEAT6_PONAB HEAT repeat-containing protein 6 OS=Pongo ... 91 3e-017
sp|Q7ZY56|HEAT6_XENLA HEAT repeat-containing protein 6 OS=Xenopu... 88 2e-016
sp|Q6AI08|HEAT6_HUMAN HEAT repeat-containing protein 6 OS=Homo s... 87 3e-016
sp|A9JRI0|HEAT6_DANRE HEAT repeat-containing protein 6 OS=Danio ... 86 8e-016
sp|Q6P1G0|HEAT6_MOUSE HEAT repeat-containing protein 6 OS=Mus mu... 83 7e-015
sp|A1EC95|HEAT6_RAT HEAT repeat-containing protein 6 OS=Rattus n... 82 1e-014
>sp|Q5R5R2|HEAT6_PONAB HEAT repeat-containing protein 6 OS=Pongo abelii
GN=HEATR6 PE=2 SV=1
Length = 1181
Score = 91 bits (223), Expect = 3e-017
Identities = 55/207 (26%), Positives = 100/207 (48%), Gaps = 11/207 (5%)
Frame = -3
Query: 875 HLSCAVDSSWLERTVQAFLSCV-TTGNVKVQWNVCHALSNLFSNETVKLQDMDWAPSVFS 699
H+ + +E ++QA +S V T +KV+WN C+A+ N+F N + L W ++
Sbjct: 943 HIEKPTFAEIIEESIQALISTVLTEAAMKVRWNACYAMGNVFKNPALPLGTAPWTSQAYN 1002
Query: 698 ILLLLLRDASNFKIRIQAAAALAVPVTPLAYGRSFPDVVKGVWHTLQNLKSDRETTP--T 525
L ++ NFK+RI++AAAL+VP YG D G+W+ L E T
Sbjct: 1003 ALTSVVTSCKNFKVRIRSAAALSVPGKREQYGS--VDQYAGIWNALVTALQKSEDTRDFL 1060
Query: 524 NFKYKRSLENQLTSTMLHLLSLVSSGRCEALTDFLLKKASFLEEWLRGLCVTLKEEDNAS 345
FKY SL Q+ ++HLL+L S+ + + L + ++ ++ + E D+
Sbjct: 1061 EFKYCASLRTQICQALIHLLNLASASDLPCIKETLELNGNMVQSYILQFIKSGAEGDDTG 1120
Query: 344 GSSSSMSISGEKQKKELISKAIRSLAS 264
S +++ +++ A++ + S
Sbjct: 1121 APHS------PQERDQMVRMALKHMGS 1141
Score = 55 bits (131), Expect = 1e-006
Identities = 35/133 (26%), Positives = 68/133 (51%), Gaps = 3/133 (2%)
Frame = -3
Query: 1316 KERDFVTSSIINAALHDKSPSVRSAACRAIGVISCFPETSLSIGIYEKFILAVEANTRDP 1137
K+R + +++ K+ V++A RA+GV FP + A+ + D
Sbjct: 809 KDRQILCITVLLGLNDSKNRLVKAATSRALGVYVLFPCLRQDVIFVADTANAILMSLEDK 868
Query: 1136 LNSVRVTSSWALANVCEAL--RYRVNDRSFEGSNTTSQVVDSLIECALRLTEDGDKVKAN 963
+VR ++W+L N+ + L D SF+ + ++ ++ A+ ++D DKVK+N
Sbjct: 869 SLNVRANAAWSLGNLTDTLIVNMETPDPSFQ-EEFSGLLLLKMLRSAIEASKDKDKVKSN 927
Query: 962 AVRALGSISKYVK 924
AVRALG++ +++
Sbjct: 928 AVRALGNLLHFLQ 940
>sp|Q7ZY56|HEAT6_XENLA HEAT repeat-containing protein 6 OS=Xenopus laevis
GN=heatr6 PE=2 SV=1
Length = 1174
Score = 88 bits (217), Expect = 2e-016
Identities = 49/156 (31%), Positives = 81/156 (51%), Gaps = 5/156 (3%)
Frame = -3
Query: 845 LERTVQAFLSCVT-TGNVKVQWNVCHALSNLFSNETVKLQDMDWAPSVFSILLLLLRDAS 669
+E +QA +S V G +KV+WN C+AL N+F N + L W + ++ L +++
Sbjct: 957 IECAIQALVSTVLGDGTMKVKWNACYALGNVFKNTALPLGKATWTAAAYNALTTVVKACK 1016
Query: 668 NFKIRIQAAAALAVPVTPLAYGRSFPDVVKGVWHTLQNLKSDRETTP--TNFKYKRSLEN 495
NFK+RI++A AL++P + YG + + +W+ L E T FKY SL
Sbjct: 1017 NFKVRIKSAMALSIPFSREQYGST--EQYCDIWNALVTALQKSEDTEDFLEFKYSASLRE 1074
Query: 494 QLTSTMLHLLSLVSSGRCEALTDFLLKKASFLEEWL 387
Q+ ++HLLSL S + LL+K + ++
Sbjct: 1075 QICQALIHLLSLASQEDLPRIRKTLLEKGDSIRNYV 1110
Score = 57 bits (135), Expect = 5e-007
Identities = 40/156 (25%), Positives = 75/156 (48%), Gaps = 8/156 (5%)
Frame = -3
Query: 1313 ERDFVTSSIINAALHDKSPSVRSAACRAIGVISCFPETSLSIGIYEKFILAVEANTRDPL 1134
+R + +++ H ++P V++AA RA+GV FP + A+ D
Sbjct: 814 DRQILCITLLLGLNHSENPLVKAAAARALGVYILFPCLRQDVMFVADTANAILMCLSDRS 873
Query: 1133 NSVRVTSSWALANVCEAL--RYRVNDRSFEGSNTTSQVVDSLIECALRLTEDGDKVKANA 960
+VR ++W+L N+ ++L +SF+ + ++ ++ A ++D DKVK+NA
Sbjct: 874 PNVRAKAAWSLGNLTDSLIVNMEAMGQSFQ-EEFSDMLLLKMLWAATEASKDKDKVKSNA 932
Query: 959 VRALGSISKYVKLRCMTSNHEALPSPHHHLSCAVDS 852
VRALG++ L + H P + CA+ +
Sbjct: 933 VRALGNL-----LHFLQPYHIVKPRFCESIECAIQA 963
>sp|Q6AI08|HEAT6_HUMAN HEAT repeat-containing protein 6 OS=Homo sapiens
GN=HEATR6 PE=1 SV=1
Length = 1181
Score = 87 bits (215), Expect = 3e-016
Identities = 55/207 (26%), Positives = 100/207 (48%), Gaps = 11/207 (5%)
Frame = -3
Query: 875 HLSCAVDSSWLERTVQAFLSCV-TTGNVKVQWNVCHALSNLFSNETVKLQDMDWAPSVFS 699
H+ + +E ++QA +S V T +KV+WN C+A+ N+F N + L W ++
Sbjct: 943 HIEKPTFAEIIEESIQALISTVLTEAAMKVRWNACYAMGNVFKNPALPLGTAPWTSQAYN 1002
Query: 698 ILLLLLRDASNFKIRIQAAAALAVPVTPLAYGRSFPDVVKGVWHTLQNL--KSDRETTPT 525
L ++ NFK+RI++AAAL+VP YG D +W+ L KS+
Sbjct: 1003 ALTSVVTSCKNFKVRIRSAAALSVPGKREQYGS--VDQYARIWNALVTALQKSEDTIDFL 1060
Query: 524 NFKYKRSLENQLTSTMLHLLSLVSSGRCEALTDFLLKKASFLEEWLRGLCVTLKEEDNAS 345
FKY SL Q+ ++HLLSL S+ + + L + ++ ++ + E D+
Sbjct: 1061 EFKYCVSLRTQICQALIHLLSLASASDLPCMKETLELSGNMVQSYILQFLKSGAEGDDTG 1120
Query: 344 GSSSSMSISGEKQKKELISKAIRSLAS 264
S +++ +++ A++ + S
Sbjct: 1121 APHS------PQERDQMVRMALKHMGS 1141
Score = 53 bits (125), Expect = 7e-006
Identities = 34/132 (25%), Positives = 67/132 (50%), Gaps = 3/132 (2%)
Frame = -3
Query: 1313 ERDFVTSSIINAALHDKSPSVRSAACRAIGVISCFPETSLSIGIYEKFILAVEANTRDPL 1134
+R + +++ K+ V++A RA+GV FP + A+ + D
Sbjct: 810 DRQMLCITVLLGLNDSKNRLVKAATSRALGVYVLFPCLRQDVIFVADAANAILMSLEDKS 869
Query: 1133 NSVRVTSSWALANVCEAL--RYRVNDRSFEGSNTTSQVVDSLIECALRLTEDGDKVKANA 960
+VR ++W+L N+ + L D SF+ + ++ ++ A+ ++D DKVK+NA
Sbjct: 870 LNVRAKAAWSLGNLTDTLIVNMETPDPSFQ-EEFSGLLLLKMLRSAIEASKDKDKVKSNA 928
Query: 959 VRALGSISKYVK 924
VRALG++ +++
Sbjct: 929 VRALGNLLHFLQ 940
>sp|A9JRI0|HEAT6_DANRE HEAT repeat-containing protein 6 OS=Danio rerio GN=heatr6
PE=2 SV=1
Length = 1201
Score = 86 bits (211), Expect = 8e-016
Identities = 70/213 (32%), Positives = 101/213 (47%), Gaps = 12/213 (5%)
Frame = -3
Query: 1043 NTTSQVVDSLIECALRLTED-GDKVKANAVRALGSISKYVKLRCMTSNHEALPSPHH--- 876
N T ++ ++ L ED D + N +R+ S K R ++ AL + H
Sbjct: 889 NLTDTLIVNMQSVGLEFQEDFSDMLLLNMLRSATKASA-DKDRVKSNAVRALGNLLHFLQ 947
Query: 875 --HLSCAVDSSWLERTVQAFLSCVT-TGNVKVQWNVCHALSNLFSNETVKLQDMDWAPSV 705
HL V L ++A + V +KV+WN C+AL N F N+ + L W+
Sbjct: 948 PGHLGKPVFEQPLLEAMRALIDTVRGDATMKVRWNACYALGNAFRNQHLPLGSAVWSTEA 1007
Query: 704 FSILLLLLRDASNFKIRIQAAAALAVPVTPLAYGRSFPDVVKGVWHTL-QNLKSDRETTP 528
FS L ++ NFK+RI++AAAL+VP T YG S VW +L Q L+ ET
Sbjct: 1008 FSALSCVVTSCKNFKVRIKSAAALSVPATRECYGDS--QQFSEVWRSLAQALEHSEETED 1065
Query: 527 -TNFKYKRSLENQLTSTMLHLLSLVSSGRCEAL 432
++Y SL +QL +LHLLSL AL
Sbjct: 1066 FLEYRYCASLRSQLCRALLHLLSLCQPDDLPAL 1098
>sp|Q6P1G0|HEAT6_MOUSE HEAT repeat-containing protein 6 OS=Mus musculus
GN=Heatr6 PE=2 SV=1
Length = 1184
Score = 83 bits (203), Expect = 7e-015
Identities = 49/156 (31%), Positives = 78/156 (50%), Gaps = 5/156 (3%)
Frame = -3
Query: 845 LERTVQAFLSCVTT-GNVKVQWNVCHALSNLFSNETVKLQDMDWAPSVFSILLLLLRDAS 669
+E ++QA +S V +KV+WN C+A+ N+F N + L W + L ++
Sbjct: 956 IEESIQALISTVVNEAAMKVRWNACYAMGNVFKNPALPLGTAPWTSQAYKALTSVVMSCK 1015
Query: 668 NFKIRIQAAAALAVPVTPLAYGRSFPDVVKGVWHTLQNL--KSDRETTPTNFKYKRSLEN 495
NFK+RI++AAAL+VP YG S ++ +W L KS+ T FKY SL
Sbjct: 1016 NFKVRIRSAAALSVPSKRGQYG-SLEQFIQ-IWSALVTALQKSEDTTDFLEFKYCASLRT 1073
Query: 494 QLTSTMLHLLSLVSSGRCEALTDFLLKKASFLEEWL 387
+ +LHLLSL S+ + + L + ++
Sbjct: 1074 HICQALLHLLSLASASDLPGIQETLKLHGDMIRSYI 1109
Score = 57 bits (135), Expect = 5e-007
Identities = 34/116 (29%), Positives = 66/116 (56%), Gaps = 3/116 (2%)
Frame = -3
Query: 1265 KSPSVRSAACRAIGVISCFPETSLSIGIYEKFILAVEANTRDPLNSVRVTSSWALANVCE 1086
K+ V++A RA+GV FP + A+ + +D +VR ++W+L N+ +
Sbjct: 829 KNHLVKAATSRALGVYVLFPCLRQDVIFVADTANAILMSLQDKSLNVRAKAAWSLGNLTD 888
Query: 1085 ALRYRVN--DRSFEGSNTTSQVVDSLIECALRLTEDGDKVKANAVRALGSISKYVK 924
L ++ D SF+ + ++ +++CA++ + D DKVK+NAVRALG++ +++
Sbjct: 889 TLIVNMDTPDPSFQ-DEFSGLLLLKMLQCAIQASTDKDKVKSNAVRALGNLLHFLQ 943
>sp|A1EC95|HEAT6_RAT HEAT repeat-containing protein 6 OS=Rattus norvegicus
GN=Heatr6 PE=2 SV=1
Length = 1252
Score = 82 bits (200), Expect = 1e-014
Identities = 47/156 (30%), Positives = 76/156 (48%), Gaps = 5/156 (3%)
Frame = -3
Query: 845 LERTVQAFLSCVTT-GNVKVQWNVCHALSNLFSNETVKLQDMDWAPSVFSILLLLLRDAS 669
+E ++QA +S V +KV+WN C+A+ N+F N + L W + L ++
Sbjct: 1024 IEESIQALISTVVNEAAMKVRWNACYAMGNVFKNPALPLGTAPWTSQAYKALTSVVMSCK 1083
Query: 668 NFKIRIQAAAALAVPVTPLAYG--RSFPDVVKGVWHTLQNLKSDRETTPTNFKYKRSLEN 495
NFK+RI++AAAL+VP YG F + + LQ +S+ T FKY SL
Sbjct: 1084 NFKVRIRSAAALSVPGRRAQYGSLEQFSQIWSALVTALQ--RSEDTTDFLEFKYCASLRT 1141
Query: 494 QLTSTMLHLLSLVSSGRCEALTDFLLKKASFLEEWL 387
+ +LHLL L S+ + + L + ++
Sbjct: 1142 HVCQALLHLLGLASASDLPCIQETLTVNGDMIRSYI 1177
Score = 53 bits (125), Expect = 7e-006
Identities = 33/116 (28%), Positives = 65/116 (56%), Gaps = 3/116 (2%)
Frame = -3
Query: 1265 KSPSVRSAACRAIGVISCFPETSLSIGIYEKFILAVEANTRDPLNSVRVTSSWALANVCE 1086
K+ V++A RA+GV FP + A+ + +D +VR ++W+L N+ +
Sbjct: 897 KNHLVKAATSRALGVYVLFPCLRQDVIFVADTANAILMSLQDKSLNVRAKAAWSLGNLTD 956
Query: 1085 ALRYRVN--DRSFEGSNTTSQVVDSLIECALRLTEDGDKVKANAVRALGSISKYVK 924
L ++ D SF+ + ++ +++ A++ + D DKVK+NAVRALG++ +++
Sbjct: 957 TLIVNMDTPDPSFQ-DEFSGLLLLKMLQSAIQASTDKDKVKSNAVRALGNLLHFLQ 1011
Database: UniProt/SwissProt
Posted date: Sat Aug 07 14:36:18 2010
Number of letters in database: 182,829,261
Number of sequences in database: 518,415
Lambda K H
0.267 0.041 0.140
Gapped
Lambda K H
0.267 0.041 0.140
Matrix: blosum62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 106,282,147,502
Number of Sequences: 518415
Number of Extensions: 106282147502
Number of Successful Extensions: 672117376
Number of sequences better than 0.0: 0
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