BLASTX 7.6.2
Query= UN25806 /QuerySize=1395
(1394 letters)
Database: UniProt/SwissProt;
518,415 sequences; 182,829,261 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|O80397|M2K4_ARATH Mitogen-activated protein kinase kinase 4 O... 593 1e-168
sp|Q8RXG3|M2K5_ARATH Mitogen-activated protein kinase kinase 5 O... 521 5e-147
sp|Q5QN75|M2K1_ORYSJ Mitogen-activated protein kinase kinase 1 O... 219 4e-056
sp|Q9FJV0|M2K6_ARATH Mitogen-activated protein kinase kinase 6 O... 203 3e-051
sp|Q9S7U9|M2K2_ARATH Mitogen-activated protein kinase kinase 2 O... 198 8e-050
sp|Q94A06|M2K1_ARATH Mitogen-activated protein kinase kinase 1 O... 198 1e-049
sp|Q13163|MP2K5_HUMAN Dual specificity mitogen-activated protein... 176 3e-043
sp|Q62862|MP2K5_RAT Dual specificity mitogen-activated protein k... 176 6e-043
sp|Q9WVS7|MP2K5_MOUSE Dual specificity mitogen-activated protein... 174 1e-042
sp|Q54JG7|DST4_DICDI Serine/threonine-protein kinase dst4 OS=Dic... 154 2e-036
sp|Q9H2G2|SLK_HUMAN STE20-like serine/threonine-protein kinase O... 145 1e-033
sp|O55092|SLK_CAVPO STE20-like serine/threonine-protein kinase O... 143 4e-033
sp|O54988|SLK_MOUSE STE20-like serine/threonine-protein kinase O... 143 4e-033
sp|O08815|SLK_RAT STE20-like serine/threonine-protein kinase OS=... 143 4e-033
sp|Q8BLF2|CDKL3_MOUSE Cyclin-dependent kinase-like 3 OS=Mus musc... 131 2e-029
sp|Q9UKE5|TNIK_HUMAN TRAF2 and NCK-interacting protein kinase OS... 119 5e-026
sp|P83510|TNIK_MOUSE Traf2 and NCK-interacting protein kinase OS... 119 5e-026
sp|P04551|CDK1_SCHPO Cell division control protein 2 OS=Schizosa... 104 3e-021
sp|O95819|M4K4_HUMAN Mitogen-activated protein kinase kinase kin... 102 6e-021
>sp|O80397|M2K4_ARATH Mitogen-activated protein kinase kinase 4 OS=Arabidopsis
thaliana GN=MKK4 PE=1 SV=1
Length = 366
Score = 593 bits (1528), Expect = 1e-168
Identities = 301/364 (82%), Positives = 322/364 (88%), Gaps = 14/364 (3%)
Frame = +1
Query: 136 MKPVQSLP---VPVKNPSRRRVDLRLPLPQRDVSLAVPLPLPPTSSGS-SSSSSGPSAPP 303
M+P+QS P VPVK+ RRR DL LPLPQRDVSLAVPLPLPPTS GS SS S PS+
Sbjct: 1 MRPIQSPPGVSVPVKSRPRRRPDLTLPLPQRDVSLAVPLPLPPTSGGSGGSSGSAPSSGG 60
Query: 304 SSN---------PKNYSDLERGNRIGSGAGGTVYKVIHRPTSRVYALKVIYGNHEENVRR 456
S++ KNYSDL RGNRIGSGAGGTVYKVIHRP+SR+YALKVIYGNHEE VRR
Sbjct: 61 SASSTNTNSSIEAKNYSDLVRGNRIGSGAGGTVYKVIHRPSSRLYALKVIYGNHEETVRR 120
Query: 457 QICREIEILRDVSHPNIVRCHEMFDQNGEIQVLLEFMDEGSLEGRHVSNERDLAKLSFQI 636
QICREIEILRDV+HPN+V+CHEMFDQNGEIQVLLEFMD+GSLEG HV E+ LA LS QI
Sbjct: 121 QICREIEILRDVNHPNVVKCHEMFDQNGEIQVLLEFMDKGSLEGAHVWKEQQLADLSRQI 180
Query: 637 LNGLAYLHGRHIVHRDIKPSNLLVNKAANVKIADFGVSRILAQTMDPCNSSVGTIAYMSP 816
L+GLAYLH RHIVHRDIKPSNLL+N A NVKIADFGVSRILAQTMDPCNSSVGTIAYMSP
Sbjct: 181 LSGLAYLHSRHIVHRDIKPSNLLINSAKNVKIADFGVSRILAQTMDPCNSSVGTIAYMSP 240
Query: 817 ERINTDLNQGRYDGYAGDIWSLGVSILEFFLGRFPFNVSRQGDWASLMCAICMSQPPEAP 996
ERINTDLNQG+YDGYAGDIWSLGVSILEF+LGRFPF VSRQGDWASLMCAICMSQPPEAP
Sbjct: 241 ERINTDLNQGKYDGYAGDIWSLGVSILEFYLGRFPFPVSRQGDWASLMCAICMSQPPEAP 300
Query: 997 ASASPEFRHFISCCLQREPGRRMTASQLLRHPFILRGASQGQNRSPQNLHQLLPPPRPLS 1176
A+ASPEFRHFISCCLQREPG+R +A QLL+HPFILR AS QNRSPQNLHQLLPPPRPLS
Sbjct: 301 ATASPEFRHFISCCLQREPGKRRSAMQLLQHPFILR-ASPSQNRSPQNLHQLLPPPRPLS 359
Query: 1177 SSSS 1188
SSSS
Sbjct: 360 SSSS 363
>sp|Q8RXG3|M2K5_ARATH Mitogen-activated protein kinase kinase 5 OS=Arabidopsis
thaliana GN=MKK5 PE=1 SV=2
Length = 348
Score = 521 bits (1341), Expect = 5e-147
Identities = 261/348 (75%), Positives = 292/348 (83%), Gaps = 10/348 (2%)
Frame = +1
Query: 136 MKPVQS---LPVPVKNPSRRRVDLRLPLPQRDVSLAVPLPLPPTSSGSSS-SSSGPSAPP 303
MKP+QS + P+KN R+R DL LPLP RDV+LAVPLPLPP SS SS+ +SS +
Sbjct: 1 MKPIQSPSGVASPMKNRLRKRPDLSLPLPHRDVALAVPLPLPPPSSSSSAPASSSAISTN 60
Query: 304 SSNPKNYSDLERGNRIGSGAGGTVYKVIHRPTSRVYALKVIYGNHEENVRRQICREIEIL 483
S K+ S+LER NRIGSGAGGTVYKVIH PTSR +ALKVIYGNHE+ VRRQICREIEIL
Sbjct: 61 ISAAKSLSELERVNRIGSGAGGTVYKVIHTPTSRPFALKVIYGNHEDTVRRQICREIEIL 120
Query: 484 RDVSHPNIVRCHEMFDQNGEIQVLLEFMDEGSLEGRHVSNERDLAKLSFQILNGLAYLHG 663
R V HPN+V+CH+MFD NGEIQVLLEFMD+GSLEG H+ E++LA LS QIL+GLAYLH
Sbjct: 121 RSVDHPNVVKCHDMFDHNGEIQVLLEFMDQGSLEGAHIWQEQELADLSRQILSGLAYLHR 180
Query: 664 RHIVHRDIKPSNLLVNKAANVKIADFGVSRILAQTMDPCNSSVGTIAYMSPERINTDLNQ 843
RHIVHRDIKPSNLL+N A NVKIADFGVSRILAQTMDPCNSSVGTIAYMSPERINTDLN
Sbjct: 181 RHIVHRDIKPSNLLINSAKNVKIADFGVSRILAQTMDPCNSSVGTIAYMSPERINTDLNH 240
Query: 844 GRYDGYAGDIWSLGVSILEFFLGRFPFNVSRQGDWASLMCAICMSQPPEAPASASPEFRH 1023
GRYDGYAGD+WSLGVSILEF+LGRFPF VSRQGDWASLMCAICMSQPPEAPA+AS EFRH
Sbjct: 241 GRYDGYAGDVWSLGVSILEFYLGRFPFAVSRQGDWASLMCAICMSQPPEAPATASQEFRH 300
Query: 1024 FISCCLQREPGRRMTASQLLRHPFILRGASQGQNRSPQNLHQLLPPPR 1167
F+SCCLQ +P +R +A QLL+HPFIL+ NL Q+LPPPR
Sbjct: 301 FVSCCLQSDPPKRWSAQQLLQHPFILKAT------GGPNLRQMLPPPR 342
>sp|Q5QN75|M2K1_ORYSJ Mitogen-activated protein kinase kinase 1 OS=Oryza sativa
subsp. japonica GN=MEK1 PE=1 SV=1
Length = 355
Score = 219 bits (557), Expect = 4e-056
Identities = 140/308 (45%), Positives = 184/308 (59%), Gaps = 22/308 (7%)
Frame = +1
Query: 298 PPSSNPK------NYSDLERGNRIGSGAGGTVYKVIHRPTSRVYALKVIYGNHEENVRRQ 459
P S+N K + DLE IG G+GG V V H+ +YALK I N +E VR+Q
Sbjct: 54 PQSTNLKVEDVQLSMDDLEMIQVIGKGSGGIVQLVRHKWVGTLYALKGIQMNIQEAVRKQ 113
Query: 460 ICREIEILRDVSHPNIVRCHEMFDQNGEIQVLLEFMDEGSLEG--RHVSN--ERDLAKLS 627
I +E++I + + +IV CH+ F NG I ++LE+MD GSL + V E LA L
Sbjct: 114 IVQELKINQATQNAHIVLCHQSFYHNGVIYLVLEYMDRGSLADIIKQVKTILEPYLAVLC 173
Query: 628 FQILNGLAYL-HGRHIVHRDIKPSNLLVNKAANVKIADFGVSRILAQTMDPCNSSVGTIA 804
Q+L GL YL H RH++HRDIKPSNLLVN+ VKI DFGVS +LA +M ++ VGT
Sbjct: 174 KQVLEGLLYLHHERHVIHRDIKPSNLLVNRKGEVKITDFGVSAVLASSMGQRDTFVGTYN 233
Query: 805 YMSPERINTDLNQGRYDGYAGDIWSLGVSILEFFLGRFPFNVSRQGDWAS---LMCAICM 975
YM+PERI+ G Y DIWSLG+ ILE +GRFP+ S W S L+ AI
Sbjct: 234 YMAPERIS-----GSSYDYKSDIWSLGLVILECAIGRFPYIPSEGEGWLSFYELLEAIVD 288
Query: 976 SQPPEAPASA-SPEFRHFISCCLQREPGRRMTASQLLRHPFILRGASQGQNRSPQNLHQL 1152
PP APA SPEF FIS C+Q++P RM+AS+LL HPFI + + ++ + L +
Sbjct: 289 QPPPSAPADQFSPEFCAFISSCIQKDPAERMSASELLNHPFIKK--FEDKDLDLRILVES 346
Query: 1153 LPPPRPLS 1176
L PP +S
Sbjct: 347 LEPPMNIS 354
>sp|Q9FJV0|M2K6_ARATH Mitogen-activated protein kinase kinase 6 OS=Arabidopsis
thaliana GN=MKK6 PE=1 SV=1
Length = 356
Score = 203 bits (515), Expect = 3e-051
Identities = 122/268 (45%), Positives = 164/268 (61%), Gaps = 16/268 (5%)
Frame = +1
Query: 328 DLERGNRIGSGAGGTVYKVIHRPTSRVYALKVIYGNHEENVRRQICREIEILRDVSH-PN 504
DLE IG G+GG V V H+ + +A+KVI N +E +R+QI +E++I + S P+
Sbjct: 69 DLETVKVIGKGSGGVVQLVRHKWVGKFFAMKVIQMNIQEEIRKQIVQELKINQASSQCPH 128
Query: 505 IVRCHEMFDQNGEIQVLLEFMDEGSLEG--RHVSN--ERDLAKLSFQILNGLAYLHG-RH 669
+V C+ F NG ++LE+MD GSL R V E LA + Q+L GL YLH RH
Sbjct: 129 VVVCYHSFYHNGAFSLVLEYMDRGSLADVIRQVKTILEPYLAVVCKQVLLGLVYLHNERH 188
Query: 670 IVHRDIKPSNLLVNKAANVKIADFGVSRILAQTMDPCNSSVGTIAYMSPERINTDLNQGR 849
++HRDIKPSNLLVN VKI+DFGVS LA +M ++ VGT YMSPERI+ G
Sbjct: 189 VIHRDIKPSNLLVNHKGEVKISDFGVSASLASSMGQRDTFVGTYNYMSPERIS-----GS 243
Query: 850 YDGYAGDIWSLGVSILEFFLGRFPFNVSRQ----GDWASLMCAICMSQPPEAPASA-SPE 1014
Y+ DIWSLG+S+LE +GRFP+ S + L+ AI + PP AP+ SPE
Sbjct: 244 TYDYSSDIWSLGMSVLECAIGRFPYLESEDQQNPPSFYELLAAIVENPPPTAPSDQFSPE 303
Query: 1015 FRHFISCCLQREPGRRMTASQLLRHPFI 1098
F F+S C+Q++P R ++ LL HPFI
Sbjct: 304 FCSFVSACIQKDPPARASSLDLLSHPFI 331
>sp|Q9S7U9|M2K2_ARATH Mitogen-activated protein kinase kinase 2 OS=Arabidopsis
thaliana GN=MKK2 PE=1 SV=2
Length = 363
Score = 198 bits (503), Expect = 8e-050
Identities = 119/285 (41%), Positives = 165/285 (57%), Gaps = 15/285 (5%)
Frame = +1
Query: 301 PSSNPKNYSDLERGNRIGSGAGGTVYKVIHRPTSRVYALKVIYGNHEENVRRQICREIEI 480
P+ + + SDL+ IG G+ G V V H+ T + +ALKVI N +E +R+ I +E++I
Sbjct: 60 PADDQLSLSDLDMVKVIGKGSSGVVQLVQHKWTGQFFALKVIQLNIDEAIRKAIAQELKI 119
Query: 481 LRDVSHPNIVRCHEMFDQNGEIQVLLEFMDEGS----LEGRHVSNERDLAKLSFQILNGL 648
+ PN+V ++ F NG I ++LE+MD GS L+ + L+ + Q+L GL
Sbjct: 120 NQSSQCPNLVTSYQSFYDNGAISLILEYMDGGSLADFLKSVKAIPDSYLSAIFRQVLQGL 179
Query: 649 AYL-HGRHIVHRDIKPSNLLVNKAANVKIADFGVSRILAQTMDPCNSSVGTIAYMSPERI 825
YL H RHI+HRD+KPSNLL+N VKI DFGVS ++ T N+ VGT YMSPERI
Sbjct: 180 IYLHHDRHIIHRDLKPSNLLINHRGEVKITDFGVSTVMTNTAGLANTFVGTYNYMSPERI 239
Query: 826 NTDLNQGRYDGYAGDIWSLGVSILEFFLGRFPFNVSRQGD-WAS---LMCAICMSQPPEA 993
G G DIWSLG+ +LE G+FP+ Q + W S LM AI PP
Sbjct: 240 -----VGNKYGNKSDIWSLGLVVLECATGKFPYAPPNQEETWTSVFELMEAIVDQPPPAL 294
Query: 994 PA-SASPEFRHFISCCLQREPGRRMTASQLLRHPFILRGASQGQN 1125
P+ + SPE FIS CLQ++P R +A +L+ HPF+ + G N
Sbjct: 295 PSGNFSPELSSFISTCLQKDPNSRSSAKELMEHPFLNKYDYSGIN 339
>sp|Q94A06|M2K1_ARATH Mitogen-activated protein kinase kinase 1 OS=Arabidopsis
thaliana GN=MKK1 PE=1 SV=2
Length = 354
Score = 198 bits (501), Expect = 1e-049
Identities = 129/311 (41%), Positives = 174/311 (55%), Gaps = 21/311 (6%)
Frame = +1
Query: 277 SSSGPSAPPS----SNPKNYSDLERGNRIGSGAGGTVYKVIHRPTSRVYALKVIYGNHEE 444
S S P APP N + +DLE IG G+ G V V H+ T + +ALKVI N EE
Sbjct: 46 SLSEPGAPPPIEPLDNQLSLADLEVIKVIGKGSSGNVQLVKHKLTQQFFALKVIQLNTEE 105
Query: 445 NVRRQICREIEILRDVSHPNIVRCHEMFDQNGEIQVLLEFMDEGSLEG--RHVSN--ERD 612
+ R I +E+ I P +V C++ F NG + ++LEFMD GSL + V E
Sbjct: 106 STCRAISQELRINLSSQCPYLVSCYQSFYHNGLVSIILEFMDGGSLADLLKKVGKVPENM 165
Query: 613 LAKLSFQILNGLAYL-HGRHIVHRDIKPSNLLVNKAANVKIADFGVSRILAQTMDPCNSS 789
L+ + ++L GL Y+ H R I+HRD+KPSNLL+N VKI DFGVS+IL T NS
Sbjct: 166 LSAICKRVLRGLCYIHHERRIIHRDLKPSNLLINHRGEVKITDFGVSKILTSTSSLANSF 225
Query: 790 VGTIAYMSPERINTDLNQGRYDGYAGDIWSLGVSILEFFLGRFPFN-VSRQGDWAS---L 957
VGT YMSPERI+ L + DIWSLG+ +LE G+FP+ + W+S L
Sbjct: 226 VGTYPYMSPERISGSLYSNK-----SDIWSLGLVLLECATGKFPYTPPEHKKGWSSVYEL 280
Query: 958 MCAICMSQPPEAPASA-SPEFRHFISCCLQREPGRRMTASQLLRHPFILRGASQGQNRSP 1134
+ AI + PP AP++ SPEF FIS C+Q++P R +A +LL H F+ N S
Sbjct: 281 VDAIVENPPPCAPSNLFSPEFCSFISQCVQKDPRDRKSAKELLEHKFVKMFEDSDTNLSA 340
Query: 1135 --QNLHQLLPP 1161
+ L+PP
Sbjct: 341 YFTDAGSLIPP 351
Score = 196 bits (497), Expect = 4e-049
Identities = 121/286 (42%), Positives = 165/286 (57%), Gaps = 15/286 (5%)
Frame = +1
Query: 271 SSSSSGPSAPPSSNPKNYSDLERGNRIGSGAGGTVYKVIHRPTSRVYALKVIYGNHEENV 450
S + P P N + +DLE IG G+ G V V H+ T + +ALKVI N EE+
Sbjct: 48 SEPGAPPPIEPLDNQLSLADLEVIKVIGKGSSGNVQLVKHKLTQQFFALKVIQLNTEEST 107
Query: 451 RRQICREIEILRDVSHPNIVRCHEMFDQNGEIQVLLEFMDEGSLEG--RHVSN--ERDLA 618
R I +E+ I P +V C++ F NG + ++LEFMD GSL + V E L+
Sbjct: 108 CRAISQELRINLSSQCPYLVSCYQSFYHNGLVSIILEFMDGGSLADLLKKVGKVPENMLS 167
Query: 619 KLSFQILNGLAYL-HGRHIVHRDIKPSNLLVNKAANVKIADFGVSRILAQTMDPCNSSVG 795
+ ++L GL Y+ H R I+HRD+KPSNLL+N VKI DFGVS+IL T NS VG
Sbjct: 168 AICKRVLRGLCYIHHERRIIHRDLKPSNLLINHRGEVKITDFGVSKILTSTSSLANSFVG 227
Query: 796 TIAYMSPERINTDLNQGRYDGYAGDIWSLGVSILEFFLGRFPFN-VSRQGDWAS---LMC 963
T YMSPERI+ L + DIWSLG+ +LE G+FP+ + W+S L+
Sbjct: 228 TYPYMSPERISGSLYSNK-----SDIWSLGLVLLECATGKFPYTPPEHKKGWSSVYELVD 282
Query: 964 AICMSQPPEAPASA-SPEFRHFISCCLQREPGRRMTASQLLRHPFI 1098
AI + PP AP++ SPEF FIS C+Q++P R +A +LL H F+
Sbjct: 283 AIVENPPPCAPSNLFSPEFCSFISQCVQKDPRDRKSAKELLEHKFV 328
>sp|Q13163|MP2K5_HUMAN Dual specificity mitogen-activated protein kinase kinase
5 OS=Homo sapiens GN=MAP2K5 PE=1 SV=2
Length = 448
Score = 176 bits (446), Expect = 3e-043
Identities = 115/341 (33%), Positives = 175/341 (51%), Gaps = 20/341 (5%)
Frame = +1
Query: 112 EIELKPKAMKPVQSLPVPVKNPSRR-----RVDLRLPLPQRDVSLAVPLPLPPTSSGSSS 276
E ++ + ++P+Q P K P R +V+ R P + S AV LP S+
Sbjct: 91 EQQVNGQLIEPLQIFPRACKPPGERNIHGLKVNTRAG-PSQHSSPAVSDSLP--SNSLKK 147
Query: 277 SSSGPSAPPSSNPKNYSDLERGNRIGSGAGGTVYKVIHRPTSRVYALKVIYGNHEENVRR 456
SS+ ++ N D+ + +G G GGTVYK H P+ ++ A+KVI + +++
Sbjct: 148 SSAELKKILANGQMNEQDIRYRDTLGHGNGGTVYKAYHVPSGKILAVKVILLDITLELQK 207
Query: 457 QICREIEILRDVSHPNIVRCHEMFDQNGEIQVLLEFMDEGSLEGRHVSNERDLAKLSFQI 636
QI E+EIL I+ + F I + EFMD GSL+ E L +++ +
Sbjct: 208 QIMSELEILYKCDSSYIIGFYGAFFVENRISICTEFMDGGSLDVYRKMPEHVLGRIAVAV 267
Query: 637 LNGLAYLHGRHIVHRDIKPSNLLVNKAANVKIADFGVSRILAQTMDPCNSSVGTIAYMSP 816
+ GL YL I+HRD+KPSN+LVN VK+ DFGVS L ++ + VGT AYM+P
Sbjct: 268 VKGLTYLWSLKILHRDVKPSNMLVNTRGQVKLCDFGVSTQLVNSI--AKTYVGTNAYMAP 325
Query: 817 ERINTDLNQGRYDGYAGDIWSLGVSILEFFLGRFPFNVSRQGDWA-----SLMCAICMSQ 981
ERI+ G G D+WSLG+S +E LGRFP+ ++ + L C +
Sbjct: 326 ERIS-----GEQYGIHSDVWSLGISFMELALGRFPYPQIQKNQGSLMPLQLLQCIVDEDS 380
Query: 982 PPEAPASASPEFRHFISCCLQREPGRRMTASQLLRHPFILR 1104
P S F HFI+ C++++P R +L+ HPFI++
Sbjct: 381 PVLPVGEFSEPFVHFITQCMRKQPKERPAPEELMGHPFIVQ 421
>sp|Q62862|MP2K5_RAT Dual specificity mitogen-activated protein kinase kinase 5
OS=Rattus norvegicus GN=Map2k5 PE=1 SV=1
Length = 448
Score = 176 bits (444), Expect = 6e-043
Identities = 114/341 (33%), Positives = 174/341 (51%), Gaps = 20/341 (5%)
Frame = +1
Query: 112 EIELKPKAMKPVQSLPVPVKNPSRR-----RVDLRLPLPQRDVSLAVPLPLPPTSSGSSS 276
E ++ + ++P+Q P K P R +V+ R P + S V LP S SS
Sbjct: 91 EQQVNGQLIEPLQIFPRACKPPGERNIHGLKVNTRAG-PSQHTSPVVSDSLPSNSLKKSS 149
Query: 277 SSSGPSAPPSSNPKNYSDLERGNRIGSGAGGTVYKVIHRPTSRVYALKVIYGNHEENVRR 456
+ ++ N D+ + +G G GGTVYK H P+ ++ A+KVI + +++
Sbjct: 150 AELRKIL--ANGQMNEQDIRYRDTLGHGNGGTVYKAYHVPSGKILAVKVILLDITLELQK 207
Query: 457 QICREIEILRDVSHPNIVRCHEMFDQNGEIQVLLEFMDEGSLEGRHVSNERDLAKLSFQI 636
QI E+EIL I+ + F I + EFMD GSL+ E L +++ +
Sbjct: 208 QIMSELEILYKCDSSYIIGFYGAFFVENRISICTEFMDGGSLDVYRKIPEHVLGRIAVAV 267
Query: 637 LNGLAYLHGRHIVHRDIKPSNLLVNKAANVKIADFGVSRILAQTMDPCNSSVGTIAYMSP 816
+ GL YL I+HRD+KPSN+LVN + VK+ DFGVS L ++ + VGT AYM+P
Sbjct: 268 VKGLTYLWSLKILHRDVKPSNMLVNTSGQVKLCDFGVSTQLVNSI--AKTYVGTNAYMAP 325
Query: 817 ERINTDLNQGRYDGYAGDIWSLGVSILEFFLGRFPFNVSRQGDWA-----SLMCAICMSQ 981
ERI+ G G D+WSLG+S +E LGRFP+ ++ + L C +
Sbjct: 326 ERIS-----GEQYGIHSDVWSLGISFMELALGRFPYPQIQKNQGSLMPLQLLQCIVDEDS 380
Query: 982 PPEAPASASPEFRHFISCCLQREPGRRMTASQLLRHPFILR 1104
P S F HFI+ C++++P R +L+ HPFI++
Sbjct: 381 PVLPLGEFSEPFVHFITQCMRKQPKERPAPEELMGHPFIVQ 421
>sp|Q9WVS7|MP2K5_MOUSE Dual specificity mitogen-activated protein kinase kinase
5 OS=Mus musculus GN=Map2k5 PE=1 SV=1
Length = 448
Score = 174 bits (441), Expect = 1e-042
Identities = 114/341 (33%), Positives = 173/341 (50%), Gaps = 20/341 (5%)
Frame = +1
Query: 112 EIELKPKAMKPVQSLPVPVKNPSRR-----RVDLRLPLPQRDVSLAVPLPLPPTSSGSSS 276
E ++ + ++P+Q P K P R +V+ R P + S V LP S SS
Sbjct: 91 EQQVNGQLIEPLQIFPRACKPPGERNIHGLKVNTRAG-PSQHTSPVVSDSLPSNSLKKSS 149
Query: 277 SSSGPSAPPSSNPKNYSDLERGNRIGSGAGGTVYKVIHRPTSRVYALKVIYGNHEENVRR 456
+ ++ N D+ + +G G GGTVYK H P+ ++ A+KVI + +++
Sbjct: 150 AELRKIL--ANGQMNEQDIRYRDTLGHGNGGTVYKAHHVPSGKILAVKVILLDITLELQK 207
Query: 457 QICREIEILRDVSHPNIVRCHEMFDQNGEIQVLLEFMDEGSLEGRHVSNERDLAKLSFQI 636
QI E+EIL I+ + F I + EFMD GSL+ E L +++ +
Sbjct: 208 QIMSELEILYKCDSSYIIGFYGAFFVENRISICTEFMDGGSLDVYRKIPEHVLGRIAVAV 267
Query: 637 LNGLAYLHGRHIVHRDIKPSNLLVNKAANVKIADFGVSRILAQTMDPCNSSVGTIAYMSP 816
+ GL YL I+HRD+KPSN+LVN VK+ DFGVS L ++ + VGT AYM+P
Sbjct: 268 VKGLTYLWSLKILHRDVKPSNMLVNTGGQVKLCDFGVSTQLVNSI--AKTYVGTNAYMAP 325
Query: 817 ERINTDLNQGRYDGYAGDIWSLGVSILEFFLGRFPFNVSRQGDWA-----SLMCAICMSQ 981
ERI+ G G D+WSLG+S +E LGRFP+ ++ + L C +
Sbjct: 326 ERIS-----GEQYGIHSDVWSLGISFMELALGRFPYPQIQKNQGSLMPLQLLQCIVDEDS 380
Query: 982 PPEAPASASPEFRHFISCCLQREPGRRMTASQLLRHPFILR 1104
P S F HFI+ C++++P R +L+ HPFI++
Sbjct: 381 PVLPLGEFSEPFVHFITQCMRKQPKERPAPEELMGHPFIVQ 421
>sp|Q54JG7|DST4_DICDI Serine/threonine-protein kinase dst4 OS=Dictyostelium
discoideum GN=dst4 PE=3 SV=1
Length = 485
Score = 154 bits (387), Expect = 2e-036
Identities = 102/279 (36%), Positives = 147/279 (52%), Gaps = 16/279 (5%)
Frame = +1
Query: 349 IGSGAGGTVYKVIHRPTSRVYALKVIYGNHEENVRRQICREIEILRD-VSHPNIVRCHEM 525
IG G+ G V I+ + V A+K + EEN + +EI IL++ V P IV+ H
Sbjct: 27 IGQGSFGVVCTCINTVNNEVVAIKFLEMEGEEN--SSLKKEITILKNTVRCPYIVKYHGC 84
Query: 526 FDQNGEIQVLLEFMDEGSLEG-----RHVSNERDLAKLSFQILNGLAYLHGRHIVHRDIK 690
+ + + +++E+ D GS+ E +A + +QI+ GL YLH I+HRDIK
Sbjct: 85 YIKENNLMIVMEYCDGGSILDIMQMCSITLTEAQIAAILYQIVEGLVYLHSNKILHRDIK 144
Query: 691 PSNLLVNKAANVKIADFGVSRILAQTMDPCNSSVGTIAYMSPERINTDLNQGRYDGYAGD 870
N+LVNK K+ADFGVS IL T + VG+ +MSPE I+ YD A D
Sbjct: 145 AGNVLVNKLGQAKLADFGVSAILVNTGFKQKTVVGSPYWMSPEVISPPKGSNGYDSKA-D 203
Query: 871 IWSLGVSILEFFLGRFP-FNVSRQGDWASLMCAICMSQPP--EAPASASPEFRHFISCCL 1041
IWSLG++ +E + P FN++ ++ I Q P E P + SPEF FIS CL
Sbjct: 204 IWSLGITAIEMAESKPPLFNLNP----VKVIFVIPFRQAPTLEVPGNWSPEFNDFISVCL 259
Query: 1042 QREPGRRMTASQLLRHPFILRGASQGQNRSPQNLHQLLP 1158
+E +R +A LL HPFI +G Q + + Q +P
Sbjct: 260 NKEADKRPSAVDLLNHPFIKKGKEHSQPTISEMVEQCIP 298
>sp|Q9H2G2|SLK_HUMAN STE20-like serine/threonine-protein kinase OS=Homo sapiens
GN=SLK PE=1 SV=1
Length = 1235
Score = 145 bits (364), Expect = 1e-033
Identities = 89/270 (32%), Positives = 147/270 (54%), Gaps = 13/270 (4%)
Frame = +1
Query: 310 NPKNYSDLERGNRIGSGAGGTVYKVIHRPTSRVYALKVIYGNHEENVRRQICREIEILRD 489
NP+++ ++ +G GA G VYK ++ TS + A KVI EE + + EI+IL
Sbjct: 29 NPEDFWEII--GELGDGAFGKVYKAQNKETSVLAAAKVIDTKSEEELEDYMV-EIDILAS 85
Query: 490 VSHPNIVRCHEMFDQNGEIQVLLEFMDEGSLEGRHVSNERDLAKLSFQI-----LNGLAY 654
HPNIV+ + F + +L+EF G+++ + ER L + Q+ L+ L Y
Sbjct: 86 CDHPNIVKLLDAFYYENNLWILIEFCAGGAVDAVMLELERPLTESQIQVVCKQTLDALNY 145
Query: 655 LHGRHIVHRDIKPSNLLVNKAANVKIADFGVSRILAQTMDPCNSSVGTIAYMSPERINTD 834
LH I+HRD+K N+L ++K+ADFGVS +T+ +S +GT +M+PE + +
Sbjct: 146 LHDNKIIHRDLKAGNILFTLDGDIKLADFGVSAKNTRTIQRRDSFIGTPYWMAPEVVMCE 205
Query: 835 LNQGRYDGYAGDIWSLGVSILEFFLGRFPFNVSRQGDWASLMCAICMSQPP--EAPASAS 1008
++ R Y D+WSLG++++E P + + + ++ I S+PP P+ S
Sbjct: 206 TSKDRPYDYKADVWSLGITLIEMAEIEPPHH---ELNPMRVLLKIAKSEPPTLAQPSRWS 262
Query: 1009 PEFRHFISCCLQREPGRRMTASQLLRHPFI 1098
F+ F+ CL++ R T SQLL+HPF+
Sbjct: 263 SNFKDFLKKCLEKNVDARWTTSQLLQHPFV 292
>sp|O55092|SLK_CAVPO STE20-like serine/threonine-protein kinase OS=Cavia
porcellus GN=SLK PE=1 SV=1
Length = 1231
Score = 143 bits (359), Expect = 4e-033
Identities = 89/270 (32%), Positives = 144/270 (53%), Gaps = 13/270 (4%)
Frame = +1
Query: 310 NPKNYSDLERGNRIGSGAGGTVYKVIHRPTSRVYALKVIYGNHEENVRRQICREIEILRD 489
NP+ + E +G GA G VYK ++ T+ + A KVI EE + + EI+IL
Sbjct: 29 NPEEF--WETIGELGDGAFGKVYKAQNKETNVLAAAKVIDTKSEEELEDYMV-EIDILAS 85
Query: 490 VSHPNIVRCHEMFDQNGEIQVLLEFMDEGSLEGRHVSNERDLAKLSFQI-----LNGLAY 654
HPNIV+ + F + +L+EF G+++ + ER L + Q+ L L Y
Sbjct: 86 CDHPNIVKLLDAFYYENNLWILIEFCAGGAVDAVMLELERPLTESQIQVVCKQTLEALNY 145
Query: 655 LHGRHIVHRDIKPSNLLVNKAANVKIADFGVSRILAQTMDPCNSSVGTIAYMSPERINTD 834
LH I+HRD+K N+L ++K+ADFGVS +T+ +S +GT +M+PE + +
Sbjct: 146 LHDNKIIHRDLKAGNILFTLDGDIKLADFGVSAKNTRTIQRRDSFIGTPYWMAPEVVMCE 205
Query: 835 LNQGRYDGYAGDIWSLGVSILEFFLGRFPFNVSRQGDWASLMCAICMSQPP--EAPASAS 1008
++ R Y D+WSLG++++E P + + + ++ I S+PP P+ S
Sbjct: 206 TSKDRPYDYKADVWSLGITLIEMAEIEPPHH---ELNPMRVLLKIAKSEPPTLAQPSRWS 262
Query: 1009 PEFRHFISCCLQREPGRRMTASQLLRHPFI 1098
F+ F+ CL++ R T SQLL+HPF+
Sbjct: 263 SNFKDFLKKCLEKNVDARWTTSQLLQHPFV 292
>sp|O54988|SLK_MOUSE STE20-like serine/threonine-protein kinase OS=Mus musculus
GN=Slk PE=1 SV=2
Length = 1233
Score = 143 bits (359), Expect = 4e-033
Identities = 88/270 (32%), Positives = 145/270 (53%), Gaps = 13/270 (4%)
Frame = +1
Query: 310 NPKNYSDLERGNRIGSGAGGTVYKVIHRPTSRVYALKVIYGNHEENVRRQICREIEILRD 489
NP+ + ++ +G GA G VYK ++ T+ + A KVI EE + + EI+IL
Sbjct: 29 NPEEFWEII--GELGDGAFGKVYKAQNKETNVLAAAKVIDTKSEEELEDYMV-EIDILAS 85
Query: 490 VSHPNIVRCHEMFDQNGEIQVLLEFMDEGSLEGRHVSNERDLAKLSFQI-----LNGLAY 654
HPNIV+ + F + +L+EF G+++ + ER L + Q+ L L Y
Sbjct: 86 CDHPNIVKLLDAFYYENNLWILIEFCAGGAVDAVMLELERPLTESQIQVVCKQTLEALNY 145
Query: 655 LHGRHIVHRDIKPSNLLVNKAANVKIADFGVSRILAQTMDPCNSSVGTIAYMSPERINTD 834
LH I+HRD+K N+L ++K+ADFGVS +T+ +S +GT +M+PE + +
Sbjct: 146 LHDNKIIHRDLKAGNILFTLDGDIKLADFGVSAKNTRTIQRRDSFIGTPYWMAPEVVMCE 205
Query: 835 LNQGRYDGYAGDIWSLGVSILEFFLGRFPFNVSRQGDWASLMCAICMSQPP--EAPASAS 1008
++ R Y D+WSLG++++E P + + + ++ I S+PP P+ S
Sbjct: 206 TSKDRPYDYKADVWSLGITLIEMAEIEPPHH---ELNPMRVLLKIAKSEPPTLAQPSKWS 262
Query: 1009 PEFRHFISCCLQREPGRRMTASQLLRHPFI 1098
F+ F+ CL++ R T SQLL+HPF+
Sbjct: 263 SNFKDFLRKCLEKNVDARWTTSQLLQHPFV 292
>sp|O08815|SLK_RAT STE20-like serine/threonine-protein kinase OS=Rattus
norvegicus GN=Slk PE=1 SV=1
Length = 1206
Score = 143 bits (359), Expect = 4e-033
Identities = 88/270 (32%), Positives = 145/270 (53%), Gaps = 13/270 (4%)
Frame = +1
Query: 310 NPKNYSDLERGNRIGSGAGGTVYKVIHRPTSRVYALKVIYGNHEENVRRQICREIEILRD 489
NP+ + ++ +G GA G VYK ++ T+ + A KVI EE + + EI+IL
Sbjct: 29 NPEEFWEII--GELGDGAFGKVYKAQNKETNVLAAAKVIDTKSEEELEDYMV-EIDILAS 85
Query: 490 VSHPNIVRCHEMFDQNGEIQVLLEFMDEGSLEGRHVSNERDLAKLSFQI-----LNGLAY 654
HPNIV+ + F + +L+EF G+++ + ER L + Q+ L L Y
Sbjct: 86 CDHPNIVKLLDAFYYENNLWILIEFCAGGAVDAVMLELERPLTESQIQVVCKQTLEALNY 145
Query: 655 LHGRHIVHRDIKPSNLLVNKAANVKIADFGVSRILAQTMDPCNSSVGTIAYMSPERINTD 834
LH I+HRD+K N+L ++K+ADFGVS +T+ +S +GT +M+PE + +
Sbjct: 146 LHDNKIIHRDLKAGNILFTLDGDIKLADFGVSAKNTRTIQRRDSFIGTPYWMAPEVVMCE 205
Query: 835 LNQGRYDGYAGDIWSLGVSILEFFLGRFPFNVSRQGDWASLMCAICMSQPP--EAPASAS 1008
++ R Y D+WSLG++++E P + + + ++ I S+PP P+ S
Sbjct: 206 TSKDRPYDYKADVWSLGITLIEMAEIEPPHH---ELNPMRVLLKIAKSEPPTLAQPSRWS 262
Query: 1009 PEFRHFISCCLQREPGRRMTASQLLRHPFI 1098
F+ F+ CL++ R T SQLL+HPF+
Sbjct: 263 SNFKDFLKKCLEKNVDARWTTSQLLQHPFV 292
>sp|Q8BLF2|CDKL3_MOUSE Cyclin-dependent kinase-like 3 OS=Mus musculus GN=Cdkl3
PE=2 SV=2
Length = 595
Score = 131 bits (327), Expect = 2e-029
Identities = 74/197 (37%), Positives = 109/197 (55%), Gaps = 9/197 (4%)
Frame = +1
Query: 346 RIGSGAGGTVYKVIHRPTSRVYALKVIYGNHEENVRRQICREIEILRDVSHPNIVRCHEM 525
++G G+ GTV K H+ T R+ A+K+ Y E++V + REI+ L+ H N+V E+
Sbjct: 9 KVGEGSYGTVMKCKHKDTGRIVAIKIFYEKPEKSVNKIATREIKFLKQFRHENLVNLIEV 68
Query: 526 FDQNGEIQVLLEFMDEGSLEGR----HVSNERDLAKLSFQILNGLAYLHGRHIVHRDIKP 693
F Q +I ++ EF+D L+ H + L K FQIL + YLH +I+HRDIKP
Sbjct: 69 FRQKKKIHLVFEFIDHTVLDELQHYCHGLESKRLRKYLFQILRAIEYLHNNNIIHRDIKP 128
Query: 694 SNLLVNKAANVKIADFGVSRILAQTMDPCNSSVGTIAYMSPERINTDLNQGRYDGYAGDI 873
N+LV+++ K+ DFG +R LA D V T Y +PE + D + G+ DI
Sbjct: 129 ENILVSQSGITKLCDFGFARTLAAPGDVYTDYVATRWYRAPELVLKDTSYGK----PVDI 184
Query: 874 WSLGVSILEFFLGRFPF 924
W+LG I+E G PF
Sbjct: 185 WALGCMIIEMATGH-PF 200
>sp|Q9UKE5|TNIK_HUMAN TRAF2 and NCK-interacting protein kinase OS=Homo sapiens
GN=TNIK PE=1 SV=1
Length = 1360
Score = 119 bits (298), Expect = 5e-026
Identities = 85/278 (30%), Positives = 140/278 (50%), Gaps = 27/278 (9%)
Frame = +1
Query: 349 IGSGAGGTVYKVIHRPTSRVYALKV--IYGNHEENVRRQICREIEILRDVS-HPNIVRCH 519
+G+G G VYK H T ++ A+KV + G+ EE ++ +EI +L+ S H NI +
Sbjct: 31 VGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEEEEIK----QEINMLKKYSHHRNIATYY 86
Query: 520 EMF------DQNGEIQVLLEFMDEGSLEG------RHVSNERDLAKLSFQILNGLAYLHG 663
F + ++ +++EF GS+ + E +A + +IL GL++LH
Sbjct: 87 GAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREILRGLSHLHQ 146
Query: 664 RHIVHRDIKPSNLLVNKAANVKIADFGVSRILAQTMDPCNSSVGTIAYMSPERINTDLNQ 843
++HRDIK N+L+ + A VK+ DFGVS L +T+ N+ +GT +M+PE I D N
Sbjct: 147 HKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENP 206
Query: 844 GRYDGYAGDIWSLGVSILEFFLGRFPFNVSRQGDWASLMCAICMSQPPEAPASA---SPE 1014
+ D+WSLG++ +E G P D + + + P + S +
Sbjct: 207 DATYDFKSDLWSLGITAIEMAEGAPPL-----CDMHPMRALFLIPRNPAPRLKSKKWSKK 261
Query: 1015 FRHFISCCLQREPGRRMTASQLLRHPFILRGASQGQNR 1128
F+ FI CL + +R QL++HPFI ++ Q R
Sbjct: 262 FQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVR 299
>sp|P83510|TNIK_MOUSE Traf2 and NCK-interacting protein kinase OS=Mus musculus
GN=Tnik PE=1 SV=2
Length = 1323
Score = 119 bits (298), Expect = 5e-026
Identities = 85/278 (30%), Positives = 140/278 (50%), Gaps = 27/278 (9%)
Frame = +1
Query: 349 IGSGAGGTVYKVIHRPTSRVYALKV--IYGNHEENVRRQICREIEILRDVS-HPNIVRCH 519
+G+G G VYK H T ++ A+KV + G+ EE ++ +EI +L+ S H NI +
Sbjct: 31 VGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEEEEIK----QEINMLKKYSHHRNIATYY 86
Query: 520 EMF------DQNGEIQVLLEFMDEGSLEG------RHVSNERDLAKLSFQILNGLAYLHG 663
F + ++ +++EF GS+ + E +A + +IL GL++LH
Sbjct: 87 GAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREILRGLSHLHQ 146
Query: 664 RHIVHRDIKPSNLLVNKAANVKIADFGVSRILAQTMDPCNSSVGTIAYMSPERINTDLNQ 843
++HRDIK N+L+ + A VK+ DFGVS L +T+ N+ +GT +M+PE I D N
Sbjct: 147 HKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENP 206
Query: 844 GRYDGYAGDIWSLGVSILEFFLGRFPFNVSRQGDWASLMCAICMSQPPEAPASA---SPE 1014
+ D+WSLG++ +E G P D + + + P + S +
Sbjct: 207 DATYDFKSDLWSLGITAIEMAEGAPPL-----CDMHPMRALFLIPRNPAPRLKSKKWSKK 261
Query: 1015 FRHFISCCLQREPGRRMTASQLLRHPFILRGASQGQNR 1128
F+ FI CL + +R QL++HPFI ++ Q R
Sbjct: 262 FQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVR 299
>sp|P04551|CDK1_SCHPO Cell division control protein 2 OS=Schizosaccharomyces
pombe GN=cdc2 PE=1 SV=1
Length = 297
Score = 104 bits (257), Expect = 3e-021
Identities = 67/208 (32%), Positives = 107/208 (51%), Gaps = 20/208 (9%)
Frame = +1
Query: 316 KNYSDLERGNRIGSGAGGTVYKVIHRPTSRVYALKVI-YGNHEENVRRQICREIEILRDV 492
+NY +E +IG G G VYK H+ + R+ A+K I + E V REI +L++V
Sbjct: 2 ENYQKVE---KIGEGTYGVVYKARHKLSGRIVAMKKIRLEDESEGVPSTAIREISLLKEV 58
Query: 493 ----SHPNIVRCHEMFDQNGEIQVLLEF--------MDEGSLEGRHVSNERDLAKLSFQI 636
+ N VR ++ ++ ++ EF MD S G + R + K ++Q+
Sbjct: 59 NDENNRSNCVRLLDILHAESKLYLVFEFLDMDLKKYMDRISETGATSLDPRLVQKFTYQL 118
Query: 637 LNGLAYLHGRHIVHRDIKPSNLLVNKAANVKIADFGVSRILAQTMDPCNSSVGTIAYMSP 816
+NG+ + H R I+HRD+KP NLL++K N+K+ADFG++R + + T+ Y +P
Sbjct: 119 VNGVNFCHSRRIIHRDLKPQNLLIDKEGNLKLADFGLARSFGVPLRNYTHEIVTLWYRAP 178
Query: 817 ERINTDLNQGRYDGYAGDIWSLGVSILE 900
E L R+ DIWS+G E
Sbjct: 179 E----VLLGSRHYSTGVDIWSVGCIFAE 202
>sp|O95819|M4K4_HUMAN Mitogen-activated protein kinase kinase kinase kinase 4
OS=Homo sapiens GN=MAP4K4 PE=1 SV=2
Length = 1239
Score = 102 bits (254), Expect = 6e-021
Identities = 68/203 (33%), Positives = 105/203 (51%), Gaps = 10/203 (4%)
Frame = +1
Query: 541 EIQVLLEFMDEGSLEG------RHVSNERDLAKLSFQILNGLAYLHGRHIVHRDIKPSNL 702
++ +++EF GS+ + E +A +S +IL GLA+LH H++HRDIK N+
Sbjct: 100 QLWLVMEFCGAGSITDLVKNTKGNTLKEDWIAYISREILRGLAHLHIHHVIHRDIKGQNV 159
Query: 703 LVNKAANVKIADFGVSRILAQTMDPCNSSVGTIAYMSPERINTDLNQGRYDGYAGDIWSL 882
L+ + A VK+ DFGVS L +T+ N+ +GT +M+PE I D N Y D+WS
Sbjct: 160 LLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSC 219
Query: 883 GVSILEFFLGRFPFNVSRQGDWASLMCAICMSQPPEAPASA-SPEFRHFISCCLQREPGR 1059
G++ +E G P + I + PP + S +F FI CL + +
Sbjct: 220 GITAIEMAEGAPPLCDMHP---MRALFLIPRNPPPRLKSKKWSKKFFSFIEGCLVKNYMQ 276
Query: 1060 RMTASQLLRHPFILRGASQGQNR 1128
R + QLL+HPFI ++ Q R
Sbjct: 277 RPSTEQLLKHPFIRDQPNERQVR 299
Database: UniProt/SwissProt
Posted date: Sat Aug 07 14:36:18 2010
Number of letters in database: 182,829,261
Number of sequences in database: 518,415
Lambda K H
0.267 0.041 0.140
Gapped
Lambda K H
0.267 0.041 0.140
Matrix: blosum62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 106,282,147,502
Number of Sequences: 518415
Number of Extensions: 106282147502
Number of Successful Extensions: 672117376
Number of sequences better than 0.0: 0
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