BLASTX 7.6.2
Query= UN25896 /QuerySize=1588
(1587 letters)
Database: UniProt/SwissProt;
518,415 sequences; 182,829,261 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q4KL91|S36A4_XENLA Proton-coupled amino acid transporter 4 OS... 161 2e-038
sp|Q4V8B1|S36A3_RAT Proton-coupled amino acid transporter 3 OS=R... 154 3e-036
sp|Q8CH36|S36A4_MOUSE Proton-coupled amino acid transporter 4 OS... 149 9e-035
sp|Q811P0|S36A3_MOUSE Proton-coupled amino acid transporter 3 OS... 118 1e-025
sp|Q8BHK3|S36A2_MOUSE Proton-coupled amino acid transporter 2 OS... 110 4e-023
sp|Q924A5|S36A1_RAT Proton-coupled amino acid transporter 1 OS=R... 96 5e-019
sp|Q7Z2H8|S36A1_HUMAN Proton-coupled amino acid transporter 1 OS... 95 1e-018
sp|Q8K4D3|S36A1_MOUSE Proton-coupled amino acid transporter 1 OS... 95 1e-018
sp|Q495N2|S36A3_HUMAN Proton-coupled amino acid transporter 3 OS... 94 3e-018
sp|Q8K415|S36A2_RAT Proton-coupled amino acid transporter 2 OS=R... 88 1e-016
sp|Q495M3|S36A2_HUMAN Proton-coupled amino acid transporter 2 OS... 84 2e-015
sp|Q6YBV0|S36A4_HUMAN Proton-coupled amino acid transporter 4 OS... 83 6e-015
sp|P50944|AVT4_YEAST Vacuolar amino acid transporter 4 OS=Saccha... 77 2e-013
sp|Q9H598|VIAAT_HUMAN Vesicular inhibitory amino acid transporte... 57 3e-007
sp|Q95KE2|VIAAT_MACFA Vesicular inhibitory amino acid transporte... 57 3e-007
sp|O35633|VIAAT_MOUSE Vesicular inhibitory amino acid transporte... 57 3e-007
sp|O35458|VIAAT_RAT Vesicular inhibitory amino acid transporter ... 57 3e-007
sp|Q6DIV6|VIAAT_XENTR Vesicular inhibitory amino acid transporte... 57 3e-007
sp|Q6PF45|VIAAT_XENLA Vesicular inhibitory amino acid transporte... 57 4e-007
sp|P34579|UNC47_CAEEL Vesicular GABA transporter OS=Caenorhabdit... 52 8e-006
>sp|Q4KL91|S36A4_XENLA Proton-coupled amino acid transporter 4 OS=Xenopus laevis
GN=slc36a4 PE=2 SV=1
Length = 522
Score = 161 bits (405), Expect = 2e-038
Identities = 117/417 (28%), Positives = 203/417 (48%), Gaps = 35/417 (8%)
Frame = +1
Query: 232 FKTFANIFIAVVGAGVLGLPYAFKRTGWLMGVLLLLSVSVLTHHCMMLLV----YTRRKL 399
F+T ++ +G G+LGLP A K G L+G + LL +++ HCM +LV + ++
Sbjct: 90 FQTLIHLLKGNIGTGLLGLPLAMKNAGVLLGPISLLFFGIISIHCMNILVRCSHFLCQRY 149
Query: 400 DSLNGGGFSKIGSFGDLGFAVC---GSLGRLVVDLFIILSQAGFCVGYLIFIGTTLANLF 570
N G +G ++G V S GR +VD F++++Q GFC Y +F+ + +F
Sbjct: 150 KKANLGYSDTVGLALEVGPGVLQRHASFGRNLVDWFLVVTQLGFCSVYFVFLAENIKQVF 209
Query: 571 DPDSPTSLSHQFTRLGSDFFGVSSKSLYIWGCFPFQLGLNSIKTLTHLAPLSIFADLVDL 750
+ T L + S +Y++ P + L I+ L +L+ LS FA++
Sbjct: 210 EVFLETKLQQSEIGIWS-----LDLRIYMFSFLPLIIPLVFIRDLKNLSLLSFFANV--S 262
Query: 751 AAMAVVIVEDSMIILKQRPDVVAFG----GMSLFFYGMGVAVYSFEGVGMVLPLESEMKD 918
A++++IV +I P + G LFF G A+++FEG+G+VLPLE+ M+D
Sbjct: 263 MAISLLIVYQYVIRNLSDPRTLPLGTSWKTYPLFF---GTAIFAFEGIGVVLPLENRMRD 319
Query: 919 KDKFGKVLALGMGFISFIYIAFGFLGYLAFGEDTMDIITANLGA-GLISTIVQLGLCINL 1095
K F K L +GM ++ +YI+ LGY FG+ IT NL + +V++ +
Sbjct: 320 KKDFSKALNIGMAIVTTLYISLATLGYFCFGDQIKGSITLNLPQDSWLYQLVKILYSFGI 379
Query: 1096 FFTFPLMMNPVFEIV----------ERRFSGGMYSRWLLVLAVTLVALFVPNFTDFLSLV 1245
+ T+ + EI+ R+ R+ LV VA+ +P +S V
Sbjct: 380 YVTYAIQYYVPAEIILPAVTSRVQKTRKLLCEFTMRFFLVCLTCAVAVLIPRLDLVISFV 439
Query: 1246 GSSTCCILGFVLPALFHLLVFKEEMGWKQWSL--DMAIVGLGVVLAVSGTWSSLSEI 1410
G+ + L +LP L ++ + +E W + D+ I +G V ++GT+ ++ E+
Sbjct: 440 GAVSSSTLALILPPLVEIITYHKE-NLSPWVIMKDVGIAVIGFVGFIAGTYVTIEEM 495
>sp|Q4V8B1|S36A3_RAT Proton-coupled amino acid transporter 3 OS=Rattus
norvegicus GN=Slc36a3 PE=2 SV=1
Length = 477
Score = 154 bits (387), Expect = 3e-036
Identities = 113/376 (30%), Positives = 169/376 (44%), Gaps = 18/376 (4%)
Frame = +1
Query: 112 GFDKQASSSSSSSSSYTLKMPPPPREDTPLLGKGPPLSSQFKTFANIFIAVVGAGVLGLP 291
G + SSSSSS+ T+ PR L + F ++ + +G G LGLP
Sbjct: 20 GSKASSKGSSSSSSNNTVSSKKKPRRKADAL-------MFIQIFIHLLKSNIGTGFLGLP 72
Query: 292 YAFKRTGWLMGVLLLLSVSVLTHHCMMLLVYTRRKLDSLNGGGFSKIGSFGDLGFAVCGS 471
A K G L+G + LL++ LT HCM +L+ L S F C S
Sbjct: 73 LAVKNAGLLVGPVSLLAIGALTVHCMDILLNCACHLTSRLQRSFVNYEETTMYSLETCPS 132
Query: 472 --------LGRLVVDLFIILSQAGFCVGYLIFIGTTLANLFDPDSPTSLSHQFTRLGSDF 627
GR VV +I++Q GFC Y +F+ L + + TS Q R
Sbjct: 133 PWLRTHSVWGRYVVSFLLIVTQLGFCSVYFMFMADNLQQIVEEAHFTSNVCQ-PRQSLVM 191
Query: 628 FGVSSKSLYIWGCFPFQLGLNSIKTLTHLAPLSIFADLVDLAAMAVVIVEDSMIILKQRP 807
+ Y+ PF + L ++ L+ S A + L+++A++ + +I +
Sbjct: 192 TSILDTRFYMLTILPFLILLVLVQNPQVLSIFSTLATITTLSSLALIF--EYLIQIPHHS 249
Query: 808 DVVAFGGMSLFFYGMGVAVYSFEGVGMVLPLESEMKDKDKFGKVLALGMGFISFIYIAFG 987
+ F G A+++FEGVGMVLPL+S+MK +F VL LGM F+ F+YI G
Sbjct: 250 HLPLVASWKTFLLFFGTAIFTFEGVGMVLPLKSQMKSPQQFPAVLYLGMSFVIFLYICLG 309
Query: 988 FLGYLAFGEDTMDIITANLGAGLISTIVQLGLCINLFFTFPLMMNPVFEIVERRFSGGMY 1167
LGY+ FG DT IT NL + V+L + +FFT+ L + EI+
Sbjct: 310 TLGYMKFGADTQASITLNLPNCWLYQSVKLMYSVGIFFTYALQFHVPAEIIVPYVVSRAS 369
Query: 1168 SRWLLVLAVTLVALFV 1215
W L + +T+ A V
Sbjct: 370 ENWALFIDLTVRAALV 385
>sp|Q8CH36|S36A4_MOUSE Proton-coupled amino acid transporter 4 OS=Mus musculus
GN=Slc36a4 PE=2 SV=1
Length = 500
Score = 149 bits (374), Expect = 9e-035
Identities = 118/433 (27%), Positives = 211/433 (48%), Gaps = 55/433 (12%)
Frame = +1
Query: 226 SQFKTFANIFIAVVGAGVLGLPYAFKRTGWLMGVLLLLSVSVLTHHCMMLLV------YT 387
S +T ++ +G G+LGLP A K G ++G + L+ + +++ HCM +LV
Sbjct: 57 SFLQTLVHLLKGNIGTGLLGLPLAIKNAGIVLGPISLVFIGIISVHCMHILVRCSHFLCQ 116
Query: 388 RRKLDSLNGGGFSKIGSFG-DLGFAVC----GSLGRLVVDLFIILSQAGFCVGYLIFIGT 552
R K +L G+S SF + C + GR VVD F++++Q GFC Y++F+
Sbjct: 117 RFKKSTL---GYSDTVSFAMEASPWSCLQRQAAWGRQVVDFFLVITQLGFCSVYIVFLAE 173
Query: 553 TLANLFD--------PDSPTSLSHQFTRLGSDFFGVSSKSLYIWGCFPFQLGLNSIKTLT 708
+ + + + + LSH R D +Y+ P + L I+ L
Sbjct: 174 NVKQVHEGFLGSTPIVSNGSDLSHACERRSVDL------RVYMLCFLPLIILLVFIRELK 227
Query: 709 HLAPLSIFADLVDLAAMAVVIVEDSMIILKQRPD------VVAFGGMSLFFYGMGVAVYS 870
+L LS A+ + +AA V+I + +++ PD V + LFF G AV++
Sbjct: 228 NLFVLSFLAN-ISMAASLVIIYQ---YVVRNMPDPHNLPIVAGWKKYPLFF---GTAVFA 280
Query: 871 FEGVGMVLPLESEMKDKDKFGKVLALGMGFISFIYIAFGFLGYLAFGEDTMDIITANLGA 1050
FEG+G+VLPLE++M++ +F + L +GM ++ +YI+ LGY+ F ++ IT NL
Sbjct: 281 FEGIGVVLPLENQMRESKRFPQALNIGMAIVTVLYISLATLGYMCFRDEIKGSITLNLPQ 340
Query: 1051 GL-ISTIVQLGLCINLFFTFPLMMNPVFEIVERRFSGGMYSRW----------LLVLAVT 1197
+ + V++ +F T+ + EI+ + ++++W LLV
Sbjct: 341 DMWLYQSVKILYSFGIFVTYSIQFYVPAEIIIPGVTARLHAKWKRICEFGIRSLLVSITR 400
Query: 1198 LVALFVPNFTDFLSLVGSSTCCILGFVLPALFHLLVFKEEMGWKQWSL--DMAIVGLGVV 1371
A+ +P +S VG+ + L +LP L +L F ++ + W + +++I GVV
Sbjct: 401 AGAILIPRLDIVISFVGAVSSSTLALILPPLVEILTFSKD-HYNIWMILKNISIAFTGVV 459
Query: 1372 LAVSGTWSSLSEI 1410
+ GT+ ++ EI
Sbjct: 460 GFLLGTYVTVEEI 472
>sp|Q811P0|S36A3_MOUSE Proton-coupled amino acid transporter 3 OS=Mus musculus
GN=Slc36a3 PE=2 SV=1
Length = 477
Score = 118 bits (295), Expect = 1e-025
Identities = 76/242 (31%), Positives = 118/242 (48%), Gaps = 3/242 (1%)
Frame = +1
Query: 475 GRLVVDLFIILSQAGFCVGYLIFIGTTLANLFDPDSPTSLSHQFTRLGSDFFGVSSKSLY 654
GR VV +I++Q GFC Y +F+ L + + TS Q R + Y
Sbjct: 142 GRYVVSFLLIVTQLGFCSVYFMFLADNLQQIMEEAHFTSNVCQ-PRQSLVMTSILDTRFY 200
Query: 655 IWGCFPFQLGLNSIKTLTHLAPLSIFADLVDLAAMAVVIVEDSMIILKQRPDVVAFGGMS 834
+ PF + L I+ L+ S A + L+++A++ + +I ++
Sbjct: 201 MLTILPFLILLVLIQNPQVLSIFSTLATITTLSSLALIF--EYLIQTPHHSNLPLVANWK 258
Query: 835 LFFYGMGVAVYSFEGVGMVLPLESEMKDKDKFGKVLALGMGFISFIYIAFGFLGYLAFGE 1014
F G A+++FEGVGMVLPL+S+MK +F VL LGM F+ F+YI G LGY+ FG
Sbjct: 259 TFLLFFGTAIFTFEGVGMVLPLKSQMKSPQQFPAVLYLGMSFVIFLYICLGTLGYMKFGT 318
Query: 1015 DTMDIITANLGAGLISTIVQLGLCINLFFTFPLMMNPVFEIVERRFSGGMYSRWLLVLAV 1194
DT IT NL + V+L + +FFT+ L + EI+ + W L + +
Sbjct: 319 DTQASITLNLPICWLYQSVKLMYSVGIFFTYALQFHVPAEIIVPYVVSRVSENWALFVDL 378
Query: 1195 TL 1200
T+
Sbjct: 379 TV 380
>sp|Q8BHK3|S36A2_MOUSE Proton-coupled amino acid transporter 2 OS=Mus musculus
GN=Slc36a2 PE=1 SV=1
Length = 478
Score = 110 bits (273), Expect = 4e-023
Identities = 83/265 (31%), Positives = 128/265 (48%), Gaps = 18/265 (6%)
Frame = +1
Query: 649 LYIWGCFPFQLGLNSIKTLTHLAPLSIFADLVDLAAMAVVIVEDSMIILKQRPDVVAFGG 828
L + G F L + + LA +S+ LV +A + + D+ Q P V ++
Sbjct: 204 LPVLGLLVFVRNLRVLTIFSLLANISMLVSLVIIAQYIIQEIPDA----SQLPLVASWKT 259
Query: 829 MSLFFYGMGVAVYSFEGVGMVLPLESEMKDKDKFGKVLALGMGFISFIYIAFGFLGYLAF 1008
LFF G A++SFE +G+VLPLE++MKD F +L+LGM I+ +YIA G LGYL F
Sbjct: 260 YPLFF---GTAIFSFESIGVVLPLENKMKDARGFPTILSLGMSIITTLYIAIGALGYLRF 316
Query: 1009 GEDTMDIITANLGAGLISTIVQLGLCINLFFTFPLMMNPVFEIVERRFSGGMYSRW---- 1176
G+D IT NL + V+L + + T+ L EI+ + RW
Sbjct: 317 GDDIKASITLNLPNCWLYQSVKLLYVVGILCTYALQFYVPAEIIIPLAVSQVSKRWALPV 376
Query: 1177 ------LLVLAVTLVALFVPNFTDFLSLVGSSTCCILGFVLPALFHLLV-FKEEMGWKQW 1335
LV ++A+ +P LSLVGS + L ++P L ++ + E +
Sbjct: 377 DLSIRLALVCLTCMLAILIPRLDLVLSLVGSVSSSALALIIPPLLEVVTYYGEGISPLTV 436
Query: 1336 SLDMAIVGLGVVLAVSGTWSSLSEI 1410
+ D I LG + V GT+ +L E+
Sbjct: 437 TKDALISILGFMGFVVGTYQALDEL 461
>sp|Q924A5|S36A1_RAT Proton-coupled amino acid transporter 1 OS=Rattus
norvegicus GN=Slc36a1 PE=2 SV=1
Length = 475
Score = 96 bits (238), Expect = 5e-019
Identities = 63/170 (37%), Positives = 94/170 (55%), Gaps = 13/170 (7%)
Frame = +1
Query: 649 LYIWGCFPFQLGLNSIKTLTHLAPLSIFADLVDLAAMAVVIVEDSMIILKQRPD------ 810
LY+ PF + L+ I+ L L+ S+ A++ +M V ++ I+++ PD
Sbjct: 195 LYMLTFLPFLVLLSFIRNLRILSIFSLLANI----SMFVSLIMIYQFIVQRIPDPSHLPL 250
Query: 811 VVAFGGMSLFFYGMGVAVYSFEGVGMVLPLESEMKDKDKFGKVLALGMGFISFIYIAFGF 990
V + LFF G A+++FEG+G+VLPLE++MKD KF +L LGM I+ +YI+ G
Sbjct: 251 VAPWKTYPLFF---GTAIFAFEGIGVVLPLENKMKDSQKFPLILYLGMAIITVLYISLGS 307
Query: 991 LGYLAFGEDTMDIITANLGAGLISTIVQLGLCINLFFTFPLMMNPVFEIV 1140
LGYL FG D IT NL + V+L I +FFT+ L EI+
Sbjct: 308 LGYLQFGADIKGSITLNLPNCWLYQSVKLLYSIGIFFTYALQFYVAAEII 357
>sp|Q7Z2H8|S36A1_HUMAN Proton-coupled amino acid transporter 1 OS=Homo sapiens
GN=SLC36A1 PE=1 SV=1
Length = 476
Score = 95 bits (235), Expect = 1e-018
Identities = 62/170 (36%), Positives = 93/170 (54%), Gaps = 13/170 (7%)
Frame = +1
Query: 649 LYIWGCFPFQLGLNSIKTLTHLAPLSIFADLVDLAAMAVVIVEDSMIILKQRPD------ 810
LY+ PF + L I+ L L+ S+ A++ L ++ ++ I+++ PD
Sbjct: 196 LYMLSFLPFLVLLVFIRNLRALSIFSLLANITMLVSLVMIY----QFIVQRIPDPSHLPL 251
Query: 811 VVAFGGMSLFFYGMGVAVYSFEGVGMVLPLESEMKDKDKFGKVLALGMGFISFIYIAFGF 990
V + LFF G A++SFEG+GMVLPLE++MKD KF +L LGM ++ +YI+ G
Sbjct: 252 VAPWKTYPLFF---GTAIFSFEGIGMVLPLENKMKDPRKFPLILYLGMVIVTILYISLGC 308
Query: 991 LGYLAFGEDTMDIITANLGAGLISTIVQLGLCINLFFTFPLMMNPVFEIV 1140
LGYL FG + IT NL + V+L I +FFT+ L EI+
Sbjct: 309 LGYLQFGANIQGSITLNLPNCWLYQSVKLLYSIGIFFTYALQFYVPAEII 358
>sp|Q8K4D3|S36A1_MOUSE Proton-coupled amino acid transporter 1 OS=Mus musculus
GN=Slc36a1 PE=2 SV=1
Length = 475
Score = 95 bits (235), Expect = 1e-018
Identities = 62/170 (36%), Positives = 94/170 (55%), Gaps = 13/170 (7%)
Frame = +1
Query: 649 LYIWGCFPFQLGLNSIKTLTHLAPLSIFADLVDLAAMAVVIVEDSMIILKQRPD------ 810
LY+ PF + L+ I+ L L+ S+ A++ +M V ++ I+++ PD
Sbjct: 195 LYMLSFLPFLVLLSFIRNLRVLSIFSLLANI----SMFVSLIMIYQFIVQRIPDPSHLPL 250
Query: 811 VVAFGGMSLFFYGMGVAVYSFEGVGMVLPLESEMKDKDKFGKVLALGMGFISFIYIAFGF 990
V + LFF G A+++FEG+G+VLPLE++MKD KF +L LGM I+ +YI+ G
Sbjct: 251 VAPWKTYPLFF---GTAIFAFEGIGVVLPLENKMKDSQKFPLILYLGMAIITVLYISLGS 307
Query: 991 LGYLAFGEDTMDIITANLGAGLISTIVQLGLCINLFFTFPLMMNPVFEIV 1140
LGYL FG + IT NL + V+L I +FFT+ L EI+
Sbjct: 308 LGYLQFGANIKGSITLNLPNCWLYQSVKLLYSIGIFFTYALQFYVAAEII 357
>sp|Q495N2|S36A3_HUMAN Proton-coupled amino acid transporter 3 OS=Homo sapiens
GN=SLC36A3 PE=1 SV=2
Length = 470
Score = 94 bits (231), Expect = 3e-018
Identities = 59/163 (36%), Positives = 86/163 (52%), Gaps = 1/163 (0%)
Frame = +1
Query: 652 YIWGCFPFQLGLNSIKTLTHLAPLSIFADLVDLAAMAVVIVEDSMIILKQRPDVVAFGGM 831
Y+ PF + L I+ L L+ S A++ L +MA +I E M + ++
Sbjct: 192 YMLIILPFLILLVFIQNLKVLSVFSTLANITTLGSMA-LIFEYIMEGIPYPSNLPLMANW 250
Query: 832 SLFFYGMGVAVYSFEGVGMVLPLESEMKDKDKFGKVLALGMGFISFIYIAFGFLGYLAFG 1011
F G A+++FEGVGMVLPL+++MK +F VL LGM + +YI G LGY+ FG
Sbjct: 251 KTFLLFFGTAIFTFEGVGMVLPLKNQMKHPQQFSFVLYLGMSIVIILYILLGTLGYMKFG 310
Query: 1012 EDTMDIITANLGAGLISTIVQLGLCINLFFTFPLMMNPVFEIV 1140
DT IT NL + V+L I +FFT+ L + EI+
Sbjct: 311 SDTQASITLNLPNCWLYQSVKLMYSIGIFFTYALQFHVPAEII 353
>sp|Q8K415|S36A2_RAT Proton-coupled amino acid transporter 2 OS=Rattus
norvegicus GN=Slc36a2 PE=1 SV=1
Length = 481
Score = 88 bits (217), Expect = 1e-016
Identities = 63/189 (33%), Positives = 100/189 (52%), Gaps = 11/189 (5%)
Frame = +1
Query: 649 LYIWGCFPFQLGLNSIKTLTHLAPLSIFADLVDLAAMAVVIVEDSMIIL-----KQRPDV 813
LY+ P LGL + + +L L+IF+ L +++ + +++ II Q P V
Sbjct: 201 LYMLAFLPV-LGL--LVFIRNLRVLTIFSLLANVSMLVSLVIIGQYIIQGIPDPSQLPLV 257
Query: 814 VAFGGMSLFFYGMGVAVYSFEGVGMVLPLESEMKDKDKFGKVLALGMGFISFIYIAFGFL 993
++ LFF G A++SFE +G+VLPLE++MKD +F +L+LGM I+ +YIA G L
Sbjct: 258 ASWKTYPLFF---GTAIFSFESIGVVLPLENKMKDARRFPTILSLGMSIITTLYIAIGAL 314
Query: 994 GYLAFGEDTMDIITANLGAGLISTIVQLGLCINLFFTFPLMMNPVFEIVERRFSGGMYSR 1173
GYL FG+D IT NL + V+L + + T L EI+ + R
Sbjct: 315 GYLRFGDDIKASITLNLPNCWLYQSVKLLYVVGILCTHALQFYVPAEIIIPLAVSQVSKR 374
Query: 1174 WLLVLAVTL 1200
W L + +++
Sbjct: 375 WALPVDLSI 383
>sp|Q495M3|S36A2_HUMAN Proton-coupled amino acid transporter 2 OS=Homo sapiens
GN=SLC36A2 PE=2 SV=1
Length = 483
Score = 84 bits (207), Expect = 2e-015
Identities = 58/191 (30%), Positives = 98/191 (51%), Gaps = 5/191 (2%)
Frame = +1
Query: 649 LYIWGCFPFQLGLNSIKTLTHLAPLSIFADLVDLAAMAVVI--VEDSMIILKQRPDVVAF 822
LY+ PF + L I+ L L S+ A++ L ++ ++I + + + P V ++
Sbjct: 203 LYMLSFLPFLVLLVLIRNLRILTIFSMLANISMLVSLVIIIQYITQEIPDPSRLPLVASW 262
Query: 823 GGMSLFFYGMGVAVYSFEGVGMVLPLESEMKDKDKFGKVLALGMGFISFIYIAFGFLGYL 1002
LFF G A++SFE +G+VLPLE++MK+ F +L+LGM ++ +YI LGYL
Sbjct: 263 KTYPLFF---GTAIFSFESIGVVLPLENKMKNARHFPAILSLGMSIVTSLYIGMAALGYL 319
Query: 1003 AFGEDTMDIITANLGAGLISTIVQLGLCINLFFTFPLMMNPVFEIVERRFSGGMYSRWLL 1182
FG+D I+ NL + V+L + T+ L EI+ + +RW L
Sbjct: 320 RFGDDIKASISLNLPNCWLYQSVKLLYIAGILCTYALQFYVPAEIIIPFAISRVSTRWAL 379
Query: 1183 VLAVTLVALFV 1215
L +++ + V
Sbjct: 380 PLDLSIRLVMV 390
>sp|Q6YBV0|S36A4_HUMAN Proton-coupled amino acid transporter 4 OS=Homo sapiens
GN=SLC36A4 PE=2 SV=1
Length = 504
Score = 83 bits (203), Expect = 6e-015
Identities = 54/183 (29%), Positives = 96/183 (52%), Gaps = 14/183 (7%)
Frame = +1
Query: 649 LYIWGCFPFQLGLNSIKTLTHLAPLSIFADLVDLAAMAVVIVEDSMIILKQRPD------ 810
+Y+ PF + L I+ L +L LS A++ +MAV +V +++ PD
Sbjct: 211 IYMLCFLPFIILLVFIRELKNLFVLSFLANV----SMAVSLVIIYQYVVRNMPDPHNLPI 266
Query: 811 VVAFGGMSLFFYGMGVAVYSFEGVGMVLPLESEMKDKDKFGKVLALGMGFISFIYIAFGF 990
V + LFF G AV++FEG+G+VLPLE++MK+ +F + L +GMG ++ +Y+
Sbjct: 267 VAGWKKYPLFF---GTAVFAFEGIGVVLPLENQMKESKRFPQALNIGMGIVTTLYVTLAT 323
Query: 991 LGYLAFGEDTMDIITANLGAGL-ISTIVQLGLCINLFFTFPLMMNPVFEIVERRFSGGMY 1167
LGY+ F ++ IT NL + + V++ +F T+ + EI+ + +
Sbjct: 324 LGYMCFHDEIKGSITLNLPQDVWLYQSVKILYSFGIFVTYSIQFYVPAEIIIPGITSKFH 383
Query: 1168 SRW 1176
++W
Sbjct: 384 TKW 386
>sp|P50944|AVT4_YEAST Vacuolar amino acid transporter 4 OS=Saccharomyces
cerevisiae GN=AVT4 PE=1 SV=1
Length = 713
Score = 77 bits (189), Expect = 2e-013
Identities = 43/162 (26%), Positives = 88/162 (54%), Gaps = 6/162 (3%)
Frame = +1
Query: 685 LNSIKTLTHLAPLSIFADLVDLAAMAVVIVEDSMIILKQRPDVVAFG-----GMSLFFYG 849
L+ I+ ++ L+ S+ A+ +A + +VI+ + + A G +
Sbjct: 428 LSFIRNISKLSLPSLLANFFIMAGLVIVIIFTAKRLFFDLMGTPAMGVVYGLNADRWTLF 487
Query: 850 MGVAVYSFEGVGMVLPLESEMKDKDKFGKVLALGMGFISFIYIAFGFLGYLAFGEDTMDI 1029
+G A+++FEG+G+++P++ M++ +KF VLAL + + ++I+ LGYLA+G + +
Sbjct: 488 IGTAIFAFEGIGLIIPVQDSMRNPEKFPLVLALVILTATILFISIATLGYLAYGSNVQTV 547
Query: 1030 ITANL-GAGLISTIVQLGLCINLFFTFPLMMNPVFEIVERRF 1152
I NL + + ++QL I + + PL + P +I+E +F
Sbjct: 548 ILLNLPQSNIFVNLIQLFYSIAIMLSTPLQLFPAIKIIENKF 589
>sp|Q9H598|VIAAT_HUMAN Vesicular inhibitory amino acid transporter OS=Homo
sapiens GN=SLC32A1 PE=1 SV=2
Length = 525
Score = 57 bits (136), Expect = 3e-007
Identities = 33/83 (39%), Positives = 49/83 (59%)
Frame = +1
Query: 1153 SGGMYSRWLLVLAVTLVALFVPNFTDFLSLVGSSTCCILGFVLPALFHLLVFKEEMGWKQ 1332
S G+ R LV+ L+A++VP+F + L GS T L F+LP+LFHL + ++ W Q
Sbjct: 430 SWGLTLRCALVVFTLLMAIYVPHFALLMGLTGSLTGAGLCFLLPSLFHLRLLWRKLLWHQ 489
Query: 1333 WSLDMAIVGLGVVLAVSGTWSSL 1401
D+AI +G + +VSG SL
Sbjct: 490 VFFDVAIFVIGGICSVSGFVHSL 512
>sp|Q95KE2|VIAAT_MACFA Vesicular inhibitory amino acid transporter OS=Macaca
fascicularis GN=SLC32A1 PE=2 SV=1
Length = 525
Score = 57 bits (136), Expect = 3e-007
Identities = 33/83 (39%), Positives = 49/83 (59%)
Frame = +1
Query: 1153 SGGMYSRWLLVLAVTLVALFVPNFTDFLSLVGSSTCCILGFVLPALFHLLVFKEEMGWKQ 1332
S G+ R LV+ L+A++VP+F + L GS T L F+LP+LFHL + ++ W Q
Sbjct: 430 SWGLTLRCALVVFTLLMAIYVPHFALLMGLTGSLTGAGLCFLLPSLFHLRLLWRKLLWHQ 489
Query: 1333 WSLDMAIVGLGVVLAVSGTWSSL 1401
D+AI +G + +VSG SL
Sbjct: 490 VFFDVAIFVIGGICSVSGFVHSL 512
>sp|O35633|VIAAT_MOUSE Vesicular inhibitory amino acid transporter OS=Mus
musculus GN=Slc32a1 PE=1 SV=3
Length = 525
Score = 57 bits (136), Expect = 3e-007
Identities = 33/83 (39%), Positives = 49/83 (59%)
Frame = +1
Query: 1153 SGGMYSRWLLVLAVTLVALFVPNFTDFLSLVGSSTCCILGFVLPALFHLLVFKEEMGWKQ 1332
S G+ R LV+ L+A++VP+F + L GS T L F+LP+LFHL + ++ W Q
Sbjct: 430 SWGLTLRCALVVFTLLMAIYVPHFALLMGLTGSLTGAGLCFLLPSLFHLRLLWRKLLWHQ 489
Query: 1333 WSLDMAIVGLGVVLAVSGTWSSL 1401
D+AI +G + +VSG SL
Sbjct: 490 VFFDVAIFVIGGICSVSGFVHSL 512
>sp|O35458|VIAAT_RAT Vesicular inhibitory amino acid transporter OS=Rattus
norvegicus GN=Slc32a1 PE=1 SV=1
Length = 525
Score = 57 bits (136), Expect = 3e-007
Identities = 33/83 (39%), Positives = 49/83 (59%)
Frame = +1
Query: 1153 SGGMYSRWLLVLAVTLVALFVPNFTDFLSLVGSSTCCILGFVLPALFHLLVFKEEMGWKQ 1332
S G+ R LV+ L+A++VP+F + L GS T L F+LP+LFHL + ++ W Q
Sbjct: 430 SWGLTLRCALVVFTLLMAIYVPHFALLMGLTGSLTGAGLCFLLPSLFHLRLLWRKLLWHQ 489
Query: 1333 WSLDMAIVGLGVVLAVSGTWSSL 1401
D+AI +G + +VSG SL
Sbjct: 490 VFFDVAIFVIGGICSVSGFVHSL 512
>sp|Q6DIV6|VIAAT_XENTR Vesicular inhibitory amino acid transporter OS=Xenopus
tropicalis GN=slc32a1 PE=2 SV=1
Length = 518
Score = 57 bits (136), Expect = 3e-007
Identities = 32/83 (38%), Positives = 49/83 (59%)
Frame = +1
Query: 1153 SGGMYSRWLLVLAVTLVALFVPNFTDFLSLVGSSTCCILGFVLPALFHLLVFKEEMGWKQ 1332
S G+ R LV+ L+A++VP+F + L GS T L F+LP+LFHL + ++ W Q
Sbjct: 423 SWGLTLRCALVVFTLLMAIYVPHFALLMGLTGSLTGAGLCFLLPSLFHLKLLWRKLQWHQ 482
Query: 1333 WSLDMAIVGLGVVLAVSGTWSSL 1401
D++I +G + +VSG SL
Sbjct: 483 VFFDVSIFVIGSICSVSGFVHSL 505
>sp|Q6PF45|VIAAT_XENLA Vesicular inhibitory amino acid transporter OS=Xenopus
laevis GN=slc32a1 PE=2 SV=1
Length = 518
Score = 57 bits (135), Expect = 4e-007
Identities = 32/83 (38%), Positives = 49/83 (59%)
Frame = +1
Query: 1153 SGGMYSRWLLVLAVTLVALFVPNFTDFLSLVGSSTCCILGFVLPALFHLLVFKEEMGWKQ 1332
S G+ R LV+ L+A++VP+F + L GS T L F+LP+LFHL + ++ W Q
Sbjct: 423 SWGLTLRCALVVFTLLMAIYVPHFALLMGLTGSLTGAGLCFLLPSLFHLKLMWRQLLWHQ 482
Query: 1333 WSLDMAIVGLGVVLAVSGTWSSL 1401
D++I +G + +VSG SL
Sbjct: 483 VFFDVSIFVIGSICSVSGFVHSL 505
>sp|P34579|UNC47_CAEEL Vesicular GABA transporter OS=Caenorhabditis elegans
GN=unc-47 PE=1 SV=2
Length = 486
Score = 52 bits (124), Expect = 8e-006
Identities = 28/80 (35%), Positives = 45/80 (56%)
Frame = +1
Query: 1171 RWLLVLAVTLVALFVPNFTDFLSLVGSSTCCILGFVLPALFHLLVFKEEMGWKQWSLDMA 1350
R +LVL VAL VP + + LVG+ T +L F+ PALFHL + ++ + + D
Sbjct: 398 RIILVLFTLFVALSVPYLVELMGLVGNITGTMLSFIWPALFHLYIKEKTLNNFEKRFDQG 457
Query: 1351 IVGLGVVLAVSGTWSSLSEI 1410
I+ +G + +SG + S E+
Sbjct: 458 IIIMGCSVCISGVYFSSMEL 477
Database: UniProt/SwissProt
Posted date: Sat Aug 07 14:36:18 2010
Number of letters in database: 182,829,261
Number of sequences in database: 518,415
Lambda K H
0.267 0.041 0.140
Gapped
Lambda K H
0.267 0.041 0.140
Matrix: blosum62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 106,282,147,502
Number of Sequences: 518415
Number of Extensions: 106282147502
Number of Successful Extensions: 672117376
Number of sequences better than 0.0: 0
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