BLASTX 7.6.2
Query= UN26571 /QuerySize=997
(996 letters)
Database: UniProt/SwissProt;
518,415 sequences; 182,829,261 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q4UM42|TOP1_RICFE DNA topoisomerase 1 OS=Rickettsia felis GN=... 149 5e-035
sp|Q9ZDK2|TOP1_RICPR DNA topoisomerase 1 OS=Rickettsia prowazeki... 147 2e-034
sp|Q68X45|TOP1_RICTY DNA topoisomerase 1 OS=Rickettsia typhi GN=... 146 2e-034
sp|Q1RIM1|TOP1_RICBR DNA topoisomerase 1 OS=Rickettsia bellii (s... 143 2e-033
sp|Q92IH1|TOP1_RICCN DNA topoisomerase 1 OS=Rickettsia conorii G... 136 3e-031
sp|P34185|TOP1_SYNE7 DNA topoisomerase 1 OS=Synechococcus elonga... 67 1e-010
sp|P73810|TOP1_SYNY3 DNA topoisomerase 1 OS=Synechocystis sp. (s... 67 2e-010
>sp|Q4UM42|TOP1_RICFE DNA topoisomerase 1 OS=Rickettsia felis GN=topA PE=3 SV=1
Length = 776
Score = 149 bits (374), Expect = 5e-035
Identities = 83/245 (33%), Positives = 130/245 (53%), Gaps = 4/245 (1%)
Frame = +3
Query: 12 DYSFTADM*TELDNVSGGVTEWKGLLRDYWTRFSAYCKRV*NVQIQQVEKMLEKRYEDFL 191
+Y FTA + ELD ++ G EWK L ++W+ F+ + V +I ++ ++K + L
Sbjct: 531 EYDFTAGLENELDEIAAGKLEWKAALNNFWSGFNHNIESVNEQKITEIISYVQKALDYHL 590
Query: 192 FSSLPDPTRTCPSCSEGTLVFKVSKFGSGYFIGCDGYPSCKFVAKTLYGEDEDEDDPPKN 371
FS + ++ CPSC G L K+ KFG+ F+ C YP C F + G D +E+D
Sbjct: 591 FSENKE-SKACPSCKTGELSLKLGKFGA--FLACSNYPECTFRKSIVSGNDNNENDGDLA 647
Query: 372 TCVEEPKLLGVHPNTSEKVILKCGPYGHYVQLGEDKKGHVPKRANASHIKDVNSITLEGA 551
E K+LG + E + LK GPYG YVQLGE + PKR+ + N ITLE A
Sbjct: 648 ATPNENKVLGTDKDGIE-IYLKKGPYGPYVQLGEQEGKVKPKRSPVPASLNQNDITLEMA 706
Query: 552 LELLRYPLTLGNHPEDGQPVFLKLSKSGFTVRHRRTMATVPKNVEPGEVTFEKAMKLLSG 731
L+LL PL +G H + G+ + + K G +++ ++PK + ++ + AMKL+
Sbjct: 707 LKLLSLPLKIGIHKDSGEEIMIGYGKFGPYIKYMGKFISIPKKYDFLNLSLDDAMKLIED 766
Query: 732 KNVRL 746
+L
Sbjct: 767 NKAKL 771
>sp|Q9ZDK2|TOP1_RICPR DNA topoisomerase 1 OS=Rickettsia prowazekii GN=topA PE=3
SV=1
Length = 776
Score = 147 bits (369), Expect = 2e-034
Identities = 83/245 (33%), Positives = 127/245 (51%), Gaps = 4/245 (1%)
Frame = +3
Query: 12 DYSFTADM*TELDNVSGGVTEWKGLLRDYWTRFSAYCKRV*NVQIQQVEKMLEKRYEDFL 191
+Y FTA + ELD ++ G EWK L ++W F+ + V +I ++ L+K + L
Sbjct: 531 EYDFTAGLENELDEIAAGKLEWKTALNNFWRGFNHNIESVNEQKITEIINYLQKALDYHL 590
Query: 192 FSSLPDPTRTCPSCSEGTLVFKVSKFGSGYFIGCDGYPSCKFVAKTLYGEDEDEDDPPKN 371
F ++ CPSC G L K+ KFG+ F+ C YP C F + G D +ED+ +
Sbjct: 591 FGE-DKESKVCPSCKTGQLSLKLGKFGA--FLACSNYPECTFKKSIVSGNDNNEDEGDPS 647
Query: 372 TCVEEPKLLGVHPNTSEKVILKCGPYGHYVQLGEDKKGHVPKRANASHIKDVNSITLEGA 551
T + + K+LG + E + LK GPYG Y+QLGE PKR + ITLE A
Sbjct: 648 TILNDNKILGTDQDGVE-IYLKKGPYGPYIQLGEQCGKVKPKRTPVPANLKQSEITLEIA 706
Query: 552 LELLRYPLTLGNHPEDGQPVFLKLSKSGFTVRHRRTMATVPKNVEPGEVTFEKAMKLLSG 731
L+LL PL +G H + G+ + + SK G +++ +VPK + ++ AMKL+
Sbjct: 707 LKLLNLPLKIGIHKDSGEEIIIGYSKFGPYIKYMCKFISVPKKYDFLNLSLNDAMKLIQN 766
Query: 732 KNVRL 746
+L
Sbjct: 767 NKAKL 771
>sp|Q68X45|TOP1_RICTY DNA topoisomerase 1 OS=Rickettsia typhi GN=topA PE=3 SV=1
Length = 779
Score = 146 bits (368), Expect = 2e-034
Identities = 82/245 (33%), Positives = 129/245 (52%), Gaps = 4/245 (1%)
Frame = +3
Query: 12 DYSFTADM*TELDNVSGGVTEWKGLLRDYWTRFSAYCKRV*NVQIQQVEKMLEKRYEDFL 191
+Y FTA + ELD ++ G EWK L ++W+ F+ + V +I ++ L+K + L
Sbjct: 531 EYDFTAGLENELDEIAAGKLEWKTSLNNFWSGFNNNIESVNEQKITEIINYLQKALDYHL 590
Query: 192 FSSLPDPTRTCPSCSEGTLVFKVSKFGSGYFIGCDGYPSCKFVAKTLYGEDEDEDDPPKN 371
F + ++ CPSC G L K+ KFG+ F+ C YP C F + G D +ED+ +
Sbjct: 591 FGENKE-SKVCPSCKTGQLSLKLGKFGA--FLACSNYPECTFKKSIVSGNDNNEDEGNLS 647
Query: 372 TCVEEPKLLGVHPNTSEKVILKCGPYGHYVQLGEDKKGHVPKRANASHIKDVNSITLEGA 551
T + + K+LG + E + LK GPYG Y+QLGE PKR + ITLE A
Sbjct: 648 TILNDNKILGTDKDGVE-IYLKTGPYGPYIQLGEQCGKVKPKRTPVPTNLKQSEITLEVA 706
Query: 552 LELLRYPLTLGNHPEDGQPVFLKLSKSGFTVRHRRTMATVPKNVEPGEVTFEKAMKLLSG 731
L+LL PL +G H + G+ + + SK G +++ +VPK + + + A+KL+
Sbjct: 707 LKLLSLPLKIGIHKDSGEEIIIGYSKFGPYIKYMCKFISVPKKYDFLNLNLDDAIKLIEN 766
Query: 732 KNVRL 746
+L
Sbjct: 767 NKAKL 771
>sp|Q1RIM1|TOP1_RICBR DNA topoisomerase 1 OS=Rickettsia bellii (strain RML369-C)
GN=topA PE=3 SV=1
Length = 800
Score = 143 bits (360), Expect = 2e-033
Identities = 82/242 (33%), Positives = 125/242 (51%), Gaps = 5/242 (2%)
Frame = +3
Query: 12 DYSFTADM*TELDNVSGGVTEWKGLLRDYWTRFSAYCKRV*NVQIQQVEKMLEKRYEDFL 191
+Y FTA + ELD ++ G EWK L ++W F+ + V I ++ +++ + +
Sbjct: 531 EYDFTAGLENELDEIAAGKLEWKSALGNFWNGFNHNIESVNKQNITEIISYVQQALDYHI 590
Query: 192 FSSLPDPTRTCPSCSEGTLVFKVSKFGSGYFIGCDGYPSCKFVAKTLYGEDEDEDDPPKN 371
F D ++ CPSC G L K+ KFG+ F+ C YP C F + G D +E D
Sbjct: 591 FGENKD-SKVCPSCKTGELSLKLGKFGA--FLACSNYPECNFRKSIVSGNDNNEADGEAK 647
Query: 372 TCVEEPKLLGVHPNTSEKVILKCGPYGHYVQLGEDKKGHV-PKRANASHIKDVNSITLEG 548
V E K+LG E + LK GPYG Y+Q GE + PKR+ + N ITL+
Sbjct: 648 DIVNENKVLGKDKEGIE-IYLKKGPYGPYIQYGEQVDSKIKPKRSPLPAGLNQNDITLDM 706
Query: 549 ALELLRYPLTLGNHPEDGQPVFLKLSKSGFTVRHRRTMATVPKNVEPGEVTFEKAMKLLS 728
AL+LL PL +GNH E G+ V + K G +++ ++PK + ++ + AMKL+
Sbjct: 707 ALKLLSLPLKIGNHKESGEEVLVGYGKFGPYIKYMGKFISIPKKYDFLNLSLDDAMKLIE 766
Query: 729 GK 734
K
Sbjct: 767 EK 768
>sp|Q92IH1|TOP1_RICCN DNA topoisomerase 1 OS=Rickettsia conorii GN=topA PE=3
SV=1
Length = 776
Score = 136 bits (341), Expect = 3e-031
Identities = 77/245 (31%), Positives = 128/245 (52%), Gaps = 4/245 (1%)
Frame = +3
Query: 12 DYSFTADM*TELDNVSGGVTEWKGLLRDYWTRFSAYCKRV*NVQIQQVEKMLEKRYEDFL 191
+Y FTA + ELD ++ G EWK L ++W+ F+ + V +I ++ ++K + L
Sbjct: 531 EYDFTAGLENELDAIAAGKLEWKAALNNFWSGFNHNIESVNEQKITEIISYVQKALDYHL 590
Query: 192 FSSLPDPTRTCPSCSEGTLVFKVSKFGSGYFIGCDGYPSCKFVAKTLYGEDEDEDDPPKN 371
F + ++ CPSC+ G L K+ KFG+ F+ C YP C F + G D +E++
Sbjct: 591 FGENKE-SKICPSCNTGELSLKLGKFGA--FLACSNYPECTFRKSIVSGNDNNENEGEPA 647
Query: 372 TCVEEPKLLGVHPNTSEKVILKCGPYGHYVQLGEDKKGHVPKRANASHIKDVNSITLEGA 551
E K+LG + E + LK GPYG Y+QLG+ + PKR+ + N ITL+ A
Sbjct: 648 AMPNENKVLGTDKDGVE-IYLKKGPYGPYIQLGKQEGKVKPKRSPVPASLNQNDITLDIA 706
Query: 552 LELLRYPLTLGNHPEDGQPVFLKLSKSGFTVRHRRTMATVPKNVEPGEVTFEKAMKLLSG 731
L+LL PL +G H + + + + K G +++ +V K + ++ + AMKL+
Sbjct: 707 LKLLSLPLKIGIHKDSDEEIMIGYGKFGPYIKYMGQFISVQKKYDFLNLSLDDAMKLIEE 766
Query: 732 KNVRL 746
+L
Sbjct: 767 NKAKL 771
>sp|P34185|TOP1_SYNE7 DNA topoisomerase 1 OS=Synechococcus elongatus (strain PCC
7942) GN=topA PE=3 SV=2
Length = 883
Score = 67 bits (163), Expect = 1e-010
Identities = 46/130 (35%), Positives = 63/130 (48%), Gaps = 3/130 (2%)
Frame = +3
Query: 255 KVSKFGSGYFIGCDGYPSCKFVAKTLYGEDEDED--DPPKNTCVEEPKLLGVHPNTSEKV 428
++ +FG+ DG P + K L D D + E P LG HP T E +
Sbjct: 611 RIGRFGAYLEAEADGEPIKANLPKELTPADLDVQRVETLLRQKTEGPDQLGTHPETDEPI 670
Query: 429 ILKCGPYGHYVQLG-EDKKGHVPKRANASHIKDVNSITLEGALELLRYPLTLGNHPEDGQ 605
L G YG YVQLG ++ PKRA+ + +I+LE A+ LL P TLG HPE G+
Sbjct: 671 YLLTGAYGPYVQLGAATEEKPKPKRASLPKGMSLETISLEQAVGLLSLPRTLGEHPETGR 730
Query: 606 PVFLKLSKSG 635
+ L + G
Sbjct: 731 RIQAGLGRFG 740
>sp|P73810|TOP1_SYNY3 DNA topoisomerase 1 OS=Synechocystis sp. (strain PCC 6803)
GN=topA PE=3 SV=1
Length = 898
Score = 67 bits (162), Expect = 2e-010
Identities = 45/145 (31%), Positives = 70/145 (48%), Gaps = 6/145 (4%)
Frame = +3
Query: 381 EEPKLLGVHPNTSEKVILKCGPYGHYVQLGE-DKKGHVPKRANASHIKDVNSITLEGALE 557
E P +G+HP T E + + G YG YVQLGE ++ PKR + +TLE A+
Sbjct: 655 EGPDKVGIHPETGEPIFILIGAYGPYVQLGEATEENKKPKRTSLPKGVKPEDVTLEMAVG 714
Query: 558 LLRYPLTLGNHPEDGQPVFLKLSKSGFTVRH-----RRTMATVPKNVEPGEVTFEKAMKL 722
LL P LG HPE G+ + L + G V H + ++ + + +T E+A++L
Sbjct: 715 LLALPRNLGEHPESGKNIKASLGRFGPYVVHDQGKDGKDYRSLKGDDDVLTITLERALEL 774
Query: 723 LSGKNVRLCGRPKRKPTVVDEEEEE 797
L+ R K + E++E
Sbjct: 775 LAEPKRGRGSRTPLKQLGLHPEDQE 799
Database: UniProt/SwissProt
Posted date: Sat Aug 07 14:36:18 2010
Number of letters in database: 182,829,261
Number of sequences in database: 518,415
Lambda K H
0.267 0.041 0.140
Gapped
Lambda K H
0.267 0.041 0.140
Matrix: blosum62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 109,753,696,895
Number of Sequences: 518415
Number of Extensions: 109753696895
Number of Successful Extensions: 688305551
Number of sequences better than 0.0: 0
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