BLASTX 7.6.2
Query= UN26888 /QuerySize=1269
(1268 letters)
Database: UniProt/SwissProt;
518,415 sequences; 182,829,261 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q55BK0|UFD1_DICDI Ubiquitin fusion degradation protein 1 homo... 242 7e-063
sp|Q9ES53|UFD1_RAT Ubiquitin fusion degradation protein 1 homolo... 232 4e-060
sp|Q92890|UFD1_HUMAN Ubiquitin fusion degradation protein 1 homo... 231 1e-059
sp|P70362|UFD1_MOUSE Ubiquitin fusion degradation protein 1 homo... 230 2e-059
sp|Q9VTF9|UFD1_DROME Ubiquitin fusion degradation protein 1 homo... 211 1e-053
sp|O42915|UFD1_SCHPO Ubiquitin fusion degradation protein 1 OS=S... 192 7e-048
sp|P53044|UFD1_YEAST Ubiquitin fusion degradation protein 1 OS=S... 184 1e-045
sp|Q19584|UFD1_CAEEL Ubiquitin fusion degradation protein 1 homo... 168 1e-040
>sp|Q55BK0|UFD1_DICDI Ubiquitin fusion degradation protein 1 homolog
OS=Dictyostelium discoideum GN=ufd1 PE=3 SV=1
Length = 330
Score = 242 bits (615), Expect = 7e-063
Identities = 126/312 (40%), Positives = 188/312 (60%), Gaps = 22/312 (7%)
Frame = +2
Query: 239 FEQCYRCYPVTFI--EKAHLDKGDKIIMPPSALNRLASLHIEYPMLFQLSNESVGKITHC 412
+EQ ++ +P++F+ EK L+ G KI++PPSALN L+ L+I+YPMLF++SN GK +HC
Sbjct: 25 YEQKFKAFPISFLPKEKHSLESGGKILLPPSALNALSRLNIQYPMLFEISNPISGKKSHC 84
Query: 413 GVLEFTADEGLVYFPYWMMQNMSLQEGDIVRIKNMSLVKGTYIKLQPHTQDFLDITNPKA 592
GVLEF A+EG+ Y P WMMQN+ L+EG+ + IKN +L KGT++K+QP T +F+DI+NPKA
Sbjct: 85 GVLEFIAEEGICYLPLWMMQNLQLKEGEFIDIKNATLAKGTFVKIQPRTSNFIDISNPKA 144
Query: 593 ILETTLRSYSCLTTGDTIMVPYNNKQYFINVVEAKPSSAVSIIETDCEVDFAPPLDYKEP 772
+LE +LR ++ LT D IM+ YNN +Y++ VVE KP++A+SIIE D VDFAPP+D KE
Sbjct: 145 VLENSLRKFATLTKDDEIMIDYNNTKYYLKVVELKPANAISIIEADVSVDFAPPMDSKEA 204
Query: 773 EKPQKLTPLKKRTRQVEEEEPAIKVPKFTPFTGSGKRLDGKTQTESTEQEEKPTKGEDEE 952
P +P K F P + S K + G + + + + E +
Sbjct: 205 TSPSTSSP-------GSHVSGPSKGLTFGPASTSAKPIPGGKKKKDESDSDSDSDDEPKF 257
Query: 953 KLSSITPPQKSGKLVF-------------GSNSKQTSKANVKVDPKNVEQESSTKFDEAK 1093
K + T + GK+ +N+ + N + N ++TK ++ K
Sbjct: 258 KAFAGTGARLDGKVGTPLGTSPKTLNTNNNNNNNNNNNNNNNNNNNNNSNNNNTKNEDTK 317
Query: 1094 FKVFTGKKYSLK 1129
FK F+GK +SLK
Sbjct: 318 FKSFSGKGHSLK 329
>sp|Q9ES53|UFD1_RAT Ubiquitin fusion degradation protein 1 homolog OS=Rattus
norvegicus GN=Ufd1l PE=1 SV=1
Length = 307
Score = 232 bits (591), Expect = 4e-060
Identities = 126/270 (46%), Positives = 175/270 (64%), Gaps = 10/270 (3%)
Frame = +2
Query: 230 ESSFEQCYRCYPVTFI----EKAHLDKGDKIIMPPSALNRLASLHIEYPMLFQLSNESVG 397
++ F YRC+ V+ + +++ ++KG KIIMPPSAL++L+ L+I YPMLF+L+N++
Sbjct: 16 QNRFSTQYRCFSVSMLAGPNDRSDVEKGGKIIMPPSALDQLSRLNITYPMLFKLTNKNSD 75
Query: 398 KITHCGVLEFTADEGLVYFPYWMMQNMSLQEGDIVRIKNMSLVKGTYIKLQPHTQDFLDI 577
++THCGVLEF ADEG+ Y P+WMMQN+ L+EG +V++++++L TY K QP + DFLDI
Sbjct: 76 RMTHCGVLEFVADEGICYLPHWMMQNLLLEEGGLVQVESVNLQVATYSKFQPQSPDFLDI 135
Query: 578 TNPKAILETTLRSYSCLTTGDTIMVPYNNKQYFINVVEAKPSSAVSIIETDCEVDFAPPL 757
TNPKA+LE LR+++CLTTGD I + YN K Y + V+E KP AVSIIE D VDF PL
Sbjct: 136 TNPKAVLENALRNFACLTTGDVIAINYNEKIYELRVMETKPDKAVSIIECDMNVDFDAPL 195
Query: 758 DYKEPEKPQKLTPLKKRTRQVEEEEPAIKVPKFTPFTGSGKRLDGKTQTESTEQEEKPTK 937
YKEPE+P + + + + A +V F F+GSG RLDGK + E P K
Sbjct: 196 GYKEPERP--VQHEESIEGEADHSGYAGEV-GFRAFSGSGNRLDGK--KKGVEPSPSPIK 250
Query: 938 GEDEEKLSSITPPQKSGKLVFGSNSKQTSK 1027
D K K GK+ F NS+ K
Sbjct: 251 PGD-IKRGIPNYEFKLGKITFIRNSRPMVK 279
>sp|Q92890|UFD1_HUMAN Ubiquitin fusion degradation protein 1 homolog OS=Homo
sapiens GN=UFD1L PE=1 SV=3
Length = 307
Score = 231 bits (587), Expect = 1e-059
Identities = 124/270 (45%), Positives = 171/270 (63%), Gaps = 10/270 (3%)
Frame = +2
Query: 230 ESSFEQCYRCYPVTFI----EKAHLDKGDKIIMPPSALNRLASLHIEYPMLFQLSNESVG 397
++ F YRC+ V+ + +++ ++KG KIIMPPSAL++L+ L+I YPMLF+L+N++
Sbjct: 16 QNRFSTQYRCFSVSMLAGPNDRSDVEKGGKIIMPPSALDQLSRLNITYPMLFKLTNKNSD 75
Query: 398 KITHCGVLEFTADEGLVYFPYWMMQNMSLQEGDIVRIKNMSLVKGTYIKLQPHTQDFLDI 577
++THCGVLEF ADEG+ Y P+WMMQN+ L+EG +V++++++L TY K QP + DFLDI
Sbjct: 76 RMTHCGVLEFVADEGICYLPHWMMQNLLLEEGGLVQVESVNLQVATYSKFQPQSPDFLDI 135
Query: 578 TNPKAILETTLRSYSCLTTGDTIMVPYNNKQYFINVVEAKPSSAVSIIETDCEVDFAPPL 757
TNPKA+LE LR+++CLTTGD I + YN K Y + V+E KP AVSIIE D VDF PL
Sbjct: 136 TNPKAVLENALRNFACLTTGDVIAINYNEKIYELRVMETKPDKAVSIIECDMNVDFDAPL 195
Query: 758 DYKEPEKPQKLTPLKKRTRQVEEEEPAIKVPKFTPFTGSGKRLDGKTQTESTEQEEKPTK 937
YKEPE+ ++ T + F F+GSG RLDGK + E P K
Sbjct: 196 GYKEPERQ---VQHEESTEGEADHSGYAGELGFRAFSGSGNRLDGK--KKGVEPSPSPIK 250
Query: 938 GEDEEKLSSITPPQKSGKLVFGSNSKQTSK 1027
D K K GK+ F NS+ K
Sbjct: 251 PGD-IKRGIPNYEFKLGKITFIRNSRPLVK 279
>sp|P70362|UFD1_MOUSE Ubiquitin fusion degradation protein 1 homolog OS=Mus
musculus GN=Ufd1l PE=1 SV=1
Length = 307
Score = 230 bits (585), Expect = 2e-059
Identities = 124/270 (45%), Positives = 175/270 (64%), Gaps = 10/270 (3%)
Frame = +2
Query: 230 ESSFEQCYRCYPVTFI----EKAHLDKGDKIIMPPSALNRLASLHIEYPMLFQLSNESVG 397
++ F YRC+ V+ + +++ ++KG KIIMPPSAL++L+ L+I YPMLF+L+N++
Sbjct: 16 QNRFSTQYRCFSVSMLAGPNDRSDVEKGGKIIMPPSALDQLSRLNITYPMLFKLTNKNSD 75
Query: 398 KITHCGVLEFTADEGLVYFPYWMMQNMSLQEGDIVRIKNMSLVKGTYIKLQPHTQDFLDI 577
++THCGVLEF ADEG+ Y P+WMMQN+ L+EG +V++++++L TY K QP + DFLDI
Sbjct: 76 RMTHCGVLEFVADEGICYLPHWMMQNLLLEEGGLVQVESVNLQVATYSKFQPQSPDFLDI 135
Query: 578 TNPKAILETTLRSYSCLTTGDTIMVPYNNKQYFINVVEAKPSSAVSIIETDCEVDFAPPL 757
TNPKA+LE LR+++C+TTGD I + YN K Y + V+E KP AVSIIE D VDF PL
Sbjct: 136 TNPKAVLENALRNFACMTTGDVIAINYNEKIYELRVMETKPDKAVSIIECDMNVDFDAPL 195
Query: 758 DYKEPEKPQKLTPLKKRTRQVEEEEPAIKVPKFTPFTGSGKRLDGKTQTESTEQEEKPTK 937
YKEP++P + + + + A +V F F+GSG RLDGK + E P K
Sbjct: 196 GYKEPKRP--VQHEESIEGEADHSGYAGEV-GFRAFSGSGNRLDGK--KKGVEPSPSPIK 250
Query: 938 GEDEEKLSSITPPQKSGKLVFGSNSKQTSK 1027
D K K GK+ F NS+ K
Sbjct: 251 PGD-IKRGIPNYEFKLGKITFIRNSRPLVK 279
>sp|Q9VTF9|UFD1_DROME Ubiquitin fusion degradation protein 1 homolog
OS=Drosophila melanogaster GN=Ufd1-like PE=1 SV=1
Length = 316
Score = 211 bits (535), Expect = 1e-053
Identities = 109/233 (46%), Positives = 150/233 (64%), Gaps = 8/233 (3%)
Frame = +2
Query: 236 SFEQCYRCYPVTFI---EKAHLDKGDKIIMPPSALNRLASLHIEYPMLFQLSNESVGKIT 406
+F Y+C+ V+ + E+ ++KG KIIMPPSAL+ L L++EYPMLF+L+N + +
Sbjct: 16 NFHANYKCFSVSMLPGNERTDVEKGGKIIMPPSALDTLTRLNVEYPMLFKLTNVKKSRSS 75
Query: 407 HCGVLEFTADEGLVYFPYWMMQNMSLQEGDIVRIKNMSLVKGTYIKLQPHTQDFLDITNP 586
H GVLEF ADEG Y P+WMM+N+ L EGDI+ I+++SL T+ K QPH+ DFLDITNP
Sbjct: 76 HAGVLEFVADEGKCYLPHWMMENLLLGEGDILNIESVSLPVATFSKFQPHSTDFLDITNP 135
Query: 587 KAILETTLRSYSCLTTGDTIMVPYNNKQYFINVVEAKPSSAVSIIETDCEVDFAPPLDYK 766
KA+LE LR+++CLT GD I + YN K Y + V+E KP +AVSIIE D V+F P+ YK
Sbjct: 136 KAVLENALRNFACLTRGDVIAIKYNKKVYELCVLETKPGNAVSIIECDMNVEFEAPVGYK 195
Query: 767 EPEKPQKLTPLKKRTR-----QVEEEEPAIKVPKFTPFTGSGKRLDGKTQTES 910
+ + Q ++ ++ AI F GSG RLDGK + ES
Sbjct: 196 DHSETQASGSGQQGAAGTVGGEIAGATNAILEEVVETFKGSGVRLDGKKKKES 248
>sp|O42915|UFD1_SCHPO Ubiquitin fusion degradation protein 1
OS=Schizosaccharomyces pombe GN=ufd1 PE=2 SV=4
Length = 342
Score = 192 bits (486), Expect = 7e-048
Identities = 98/240 (40%), Positives = 148/240 (61%), Gaps = 9/240 (3%)
Frame = +2
Query: 215 FNGDDESSFEQCYRCYPVTFI---EKAHLDKGDKIIMPPSALNRLASLHIEYPMLFQLSN 385
F+ + F+ YRCYPV I E+ +++ G K+I+PPSAL +L+ L++ YPMLF N
Sbjct: 24 FHNNVNQRFDTRYRCYPVAMIPGEERPNVNYGGKVILPPSALEKLSRLNVSYPMLFDFEN 83
Query: 386 ESVGKITHCGVLEFTADEGLVYFPYWMMQNMSLQEGDIVRIKNMSLVKGTYIKLQPHTQD 565
E+ K TH GVLEF A+EG VY PYWMM +SL+ GD+VR+ N + +G+Y+KLQP + +
Sbjct: 84 EAAEKKTHGGVLEFIAEEGRVYLPYWMMTTLSLEPGDLVRVINTDIAQGSYVKLQPQSVN 143
Query: 566 FLDITNPKAILETTLRSYSCLTTGDTIMVPYNNKQYFINVVEAKPSSA---VSIIETDCE 736
FLDIT+ +A+LE LR++S LT D + YN++ Y I V++ +P + VS++ETD
Sbjct: 144 FLDITDHRAVLENALRNFSTLTKSDIFEILYNDQVYQIKVIDVQPDDSRHVVSVVETDLV 203
Query: 737 VDFAPPLDYKE---PEKPQKLTPLKKRTRQVEEEEPAIKVPKFTPFTGSGKRLDGKTQTE 907
VDF PP+ Y+E K Q + ++ + ++ G+G +L+GK E
Sbjct: 204 VDFDPPIGYEESLQKNKQQNIAGVQGTMVTKIGYDELVRQGDSNLMKGTGTKLNGKEVAE 263
>sp|P53044|UFD1_YEAST Ubiquitin fusion degradation protein 1 OS=Saccharomyces
cerevisiae GN=UFD1 PE=1 SV=1
Length = 361
Score = 184 bits (466), Expect = 1e-045
Identities = 86/187 (45%), Positives = 127/187 (67%), Gaps = 7/187 (3%)
Frame = +2
Query: 236 SFEQCYRCYPVTF----IEKAHLDKGDKIIMPPSALNRLASLHIEYPMLFQLSNESVGKI 403
+FE+ +RCYP+ I K + G KI +PPSAL++L+ L+I YPMLF+L+ G++
Sbjct: 20 TFEEFFRCYPIAMMNDRIRKDDANFGGKIFLPPSALSKLSMLNIRYPMLFKLTANETGRV 79
Query: 404 THCGVLEFTADEGLVYFPYWMMQNMSLQEGDIVRIKNMSLVKGTYIKLQPHTQDFLDITN 583
TH GVLEF A+EG VY P WMM+ + +Q G +++I + + G ++KL+P + DFLDI++
Sbjct: 80 THGGVLEFIAEEGRVYLPQWMMETLGIQPGSLLQISSTDVPLGQFVKLEPQSVDFLDISD 139
Query: 584 PKAILETTLRSYSCLTTGDTIMVPYNNKQYFINVVEAKP---SSAVSIIETDCEVDFAPP 754
PKA+LE LR++S LT D I + YN K + I ++E KP S ++ +IETD DFAPP
Sbjct: 140 PKAVLENVLRNFSTLTVDDVIEISYNGKTFKIKILEVKPESSSKSICVIETDLVTDFAPP 199
Query: 755 LDYKEPE 775
+ Y EP+
Sbjct: 200 VGYVEPD 206
>sp|Q19584|UFD1_CAEEL Ubiquitin fusion degradation protein 1 homolog
OS=Caenorhabditis elegans GN=ufd-1 PE=1 SV=1
Length = 342
Score = 168 bits (423), Expect = 1e-040
Identities = 86/198 (43%), Positives = 125/198 (63%), Gaps = 8/198 (4%)
Frame = +2
Query: 221 GDDESSFEQCYRCYPVTFIEKA------HLDKGDKIIMPPSALNRLASLHIEYPMLFQLS 382
G +++Q + Y F+ A ++ G KI++P SALN L +I PMLF+L+
Sbjct: 15 GGRVGNYDQTFVVYGPVFLPNATQSKISEINYGGKILLPSSALNLLMQYNIPMPMLFKLT 74
Query: 383 NESVGKITHCGVLEFTADEGLVYFPYWMMQNMSLQEGDIVRIKNMSLVKGTYIKLQPHTQ 562
N +V ++THCGVLEF+A EG P WMMQ + L +GD +RI++ +L K T+ KL+P +
Sbjct: 75 NMAVQRVTHCGVLEFSAPEGQAILPLWMMQQLGLDDGDTIRIESATLPKATFAKLKPMSL 134
Query: 563 DFLDITNPKAILETTLRSYSCLTTGDTIMVPYNNKQYFINVVEAKPSSAVSIIETDCEVD 742
+FL+ITNPKA+LE LR Y+CLT D I Y + VV+ KP+++V IIE D +D
Sbjct: 135 EFLNITNPKAVLEVELRKYACLTKNDRIPTSYAGQTLEFLVVDLKPANSVCIIECDVNLD 194
Query: 743 FAPPLDYKEPEKPQKLTP 796
F PP Y E+P+++TP
Sbjct: 195 FDPPEGY--VEQPRQVTP 210
Database: UniProt/SwissProt
Posted date: Sat Aug 07 14:36:18 2010
Number of letters in database: 182,829,261
Number of sequences in database: 518,415
Lambda K H
0.267 0.041 0.140
Gapped
Lambda K H
0.267 0.041 0.140
Matrix: blosum62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 110,275,360,721
Number of Sequences: 518415
Number of Extensions: 110275360721
Number of Successful Extensions: 693840772
Number of sequences better than 0.0: 0
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