BLASTX 7.6.2
Query= UN27002 /QuerySize=1563
(1562 letters)
Database: UniProt/SwissProt;
518,415 sequences; 182,829,261 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q69ZF3|GBA2_MOUSE Non-lysosomal glucosylceramidase OS=Mus mus... 366 3e-100
sp|Q9HCG7|GBA2_HUMAN Non-lysosomal glucosylceramidase OS=Homo sa... 363 3e-099
sp|Q5M868|GBA2_RAT Non-lysosomal glucosylceramidase OS=Rattus no... 361 8e-099
sp|Q7KT91|C3390_DROME Non-lysosomal glucosylceramidase OS=Drosop... 191 1e-047
>sp|Q69ZF3|GBA2_MOUSE Non-lysosomal glucosylceramidase OS=Mus musculus GN=Gba2
PE=2 SV=2
Length = 918
Score = 366 bits (938), Expect = 3e-100
Identities = 189/374 (50%), Positives = 233/374 (62%), Gaps = 8/374 (2%)
Frame = +1
Query: 100 DVGRFLYLEGVEYVMWNTYDVHFYASYALLMLFPKIELNIQRDFAKAVLSEDGRKVKFLA 279
D GRF YLEG EY M+NTYDVHFYAS+AL+ML+PK+EL++Q D A A L ED + ++L
Sbjct: 510 DYGRFGYLEGQEYRMYNTYDVHFYASFALVMLWPKLELSLQYDMALATLKEDLTRRRYLM 569
Query: 280 EGNLGIRKVRGAVPHDLGMHD--PWNEMNAYNIHDTSKWKDLNPKFVLQVYRDFAATGDY 453
G + K R +PHD+G D PW +NAY IHDT+ WKDLN KFVLQ+YRD+ TGD
Sbjct: 570 SGVVAPVKRRNVIPHDIGDPDDEPWLRVNAYLIHDTADWKDLNLKFVLQIYRDYYLTGDQ 629
Query: 454 QFGIDVWPAVRAAMEYMEQFDRDNDDLIENDGFPDQTYDTWTVHGVSAYCGCLWLAALQA 633
F D+WP A ME +FD+D D LIEN G+ DQTYD W G SAYCG LWLAA+
Sbjct: 630 GFLEDMWPVCLAVMESEMKFDKDQDGLIENGGYADQTYDAWVTTGPSAYCGGLWLAAVAV 689
Query: 634 AAAMALQIGDKFFAELCKNKFLNAKAALEAKLWNGTYFNYDSGASSNSKSIQTDQLAGQW 813
MA+ G + E + + A E LWNG Y+NYDS + S+SI +DQ AGQW
Sbjct: 690 MVQMAVLCGAQDVQERFASILCRGREAYERLLWNGRYYNYDSSSHPQSRSIMSDQCAGQW 749
Query: 814 YTASSGL----PPIFEDSKIKSTSQKIFDFNVMKTKGGRMGAVNGMHPDGKVDETCMQSR 981
+ + GL +F + Q IF+ NV GG MGAVNGMHP G D + +QS
Sbjct: 750 FLRACGLGEGDTEVFPTLHVVRALQTIFELNVQAFAGGAMGAVNGMHPHGVPDRSSVQSD 809
Query: 982 EIWTGVTYAAAATMILSGMEEQGFTTAEGIFTAGWSEEGFGYWFQTPEGWTMDGHYRSLI 1161
E+W GV Y AATMI G+ +GF TAEG + W E G FQTPE + +RSL
Sbjct: 810 EVWVGVVYGLAATMIQEGLTWEGFRTAEGCYRTVW--ERLGLAFQTPEAYCQQQVFRSLA 867
Query: 1162 YMRPLAIWGMQWAL 1203
YMRPL+IW MQ AL
Sbjct: 868 YMRPLSIWAMQLAL 881
>sp|Q9HCG7|GBA2_HUMAN Non-lysosomal glucosylceramidase OS=Homo sapiens GN=GBA2
PE=1 SV=2
Length = 927
Score = 363 bits (930), Expect = 3e-099
Identities = 187/374 (50%), Positives = 233/374 (62%), Gaps = 8/374 (2%)
Frame = +1
Query: 100 DVGRFLYLEGVEYVMWNTYDVHFYASYALLMLFPKIELNIQRDFAKAVLSEDGRKVKFLA 279
D GRF YLEG EY M+NTYDVHFYAS+AL+ML+PK+EL++Q D A A L ED + ++L
Sbjct: 519 DYGRFGYLEGQEYRMYNTYDVHFYASFALIMLWPKLELSLQYDMALATLREDLTRRRYLM 578
Query: 280 EGNLGIRKVRGAVPHDLGMHD--PWNEMNAYNIHDTSKWKDLNPKFVLQVYRDFAATGDY 453
G + K R +PHD+G D PW +NAY IHDT+ WKDLN KFVLQVYRD+ TGD
Sbjct: 579 SGVMAPVKRRNVIPHDIGDPDDEPWLRVNAYLIHDTADWKDLNLKFVLQVYRDYYLTGDQ 638
Query: 454 QFGIDVWPAVRAAMEYMEQFDRDNDDLIENDGFPDQTYDTWTVHGVSAYCGCLWLAALQA 633
F D+WP A ME +FD+D+D LIEN G+ DQTYD W G SAYCG LWLAA+
Sbjct: 639 NFLKDMWPVCLAVMESEMKFDKDHDGLIENGGYADQTYDGWVTTGPSAYCGGLWLAAVAV 698
Query: 634 AAAMALQIGDKFFAELCKNKFLNAKAALEAKLWNGTYFNYDSGASSNSKSIQTDQLAGQW 813
MA G + + + + A E LWNG Y+NYDS + S+S+ +DQ AGQW
Sbjct: 699 MVQMAALCGAQDIQDKFSSILSRGQEAYERLLWNGRYYNYDSSSRPQSRSVMSDQCAGQW 758
Query: 814 YTASSGL----PPIFEDSKIKSTSQKIFDFNVMKTKGGRMGAVNGMHPDGKVDETCMQSR 981
+ + GL +F + Q IF+ NV GG MGAVNGM P G D++ +QS
Sbjct: 759 FLKACGLGEGDTEVFPTQHVVRALQTIFELNVQAFAGGAMGAVNGMQPHGVPDKSSVQSD 818
Query: 982 EIWTGVTYAAAATMILSGMEEQGFTTAEGIFTAGWSEEGFGYWFQTPEGWTMDGHYRSLI 1161
E+W GV Y AATMI G+ +GF TAEG + W E G FQTPE + +RSL
Sbjct: 819 EVWVGVVYGLAATMIQEGLTWEGFQTAEGCYRTVW--ERLGLAFQTPEAYCQQRVFRSLA 876
Query: 1162 YMRPLAIWGMQWAL 1203
YMRPL+IW MQ AL
Sbjct: 877 YMRPLSIWAMQLAL 890
>sp|Q5M868|GBA2_RAT Non-lysosomal glucosylceramidase OS=Rattus norvegicus
GN=Gba2 PE=2 SV=2
Length = 912
Score = 361 bits (926), Expect = 8e-099
Identities = 190/379 (50%), Positives = 235/379 (62%), Gaps = 18/379 (4%)
Frame = +1
Query: 100 DVGRFLYLEGVEYVMWNTYDVHFYASYALLMLFPKIELNIQRDFAKAVLSEDGRKVKFLA 279
D GRF YLEG EY M+NTYDVHFYAS+AL+ML+PK+EL++Q D A A ED + ++L
Sbjct: 510 DYGRFGYLEGQEYRMYNTYDVHFYASFALVMLWPKLELSLQYDMALATFKEDLTRRRYLM 569
Query: 280 EGNLGIRKVRGAVPHDLGMHD--PWNEMNAYNIHDTSKWKDLNPKFVLQVYRDFAATGDY 453
G + K R +PHD+G D PW +NAY IHDT+ WKDLN KFVLQVYRD+ TGD
Sbjct: 570 SGVVAPVKRRNVIPHDIGDPDDEPWLRVNAYLIHDTADWKDLNLKFVLQVYRDYYLTGDQ 629
Query: 454 QFGIDVWPAVRAAMEYMEQFDRDNDDLIENDGFPDQTYDTWTVHGVSAYCGCLWLAALQA 633
F D+WP A ME +FD+D D LIEN G+ DQTYD W G SAYCG LWLAA+
Sbjct: 630 GFLKDMWPVCLAVMESEMKFDKDQDGLIENGGYADQTYDGWVTTGPSAYCGGLWLAAVAV 689
Query: 634 AAAMALQIG-----DKFFAELCKNKFLNAKAALEAKLWNGTYFNYDSGASSNSKSIQTDQ 798
MA+ G DKF + LC+ + A E LWNG Y+NYDS + S+S+ +DQ
Sbjct: 690 MVQMAVLCGAQDVQDKFSSILCR-----GREAYERLLWNGRYYNYDSSSQPQSRSVMSDQ 744
Query: 799 LAGQWYTASSGL----PPIFEDSKIKSTSQKIFDFNVMKTKGGRMGAVNGMHPDGKVDET 966
AGQW+ + GL +F + + IF+ NV GG MGAVNGM P G D +
Sbjct: 745 CAGQWFLRACGLGEGDTEVFPTLHVVRALKTIFELNVQAFAGGAMGAVNGMQPHGVPDRS 804
Query: 967 CMQSREIWTGVTYAAAATMILSGMEEQGFTTAEGIFTAGWSEEGFGYWFQTPEGWTMDGH 1146
+QS E+W GV Y AATMI G+ +GF TAEG + W E G FQTPE +
Sbjct: 805 SVQSDEVWVGVVYGLAATMIQEGLTWEGFRTAEGCYRTVW--ERLGLAFQTPEAYCQQRV 862
Query: 1147 YRSLIYMRPLAIWGMQWAL 1203
+RSL YMRPL+IW MQ AL
Sbjct: 863 FRSLAYMRPLSIWAMQLAL 881
>sp|Q7KT91|C3390_DROME Non-lysosomal glucosylceramidase OS=Drosophila
melanogaster GN=CG33090 PE=1 SV=1
Length = 948
Score = 191 bits (485), Expect = 1e-047
Identities = 108/261 (41%), Positives = 150/261 (57%), Gaps = 11/261 (4%)
Frame = +1
Query: 469 VWPAVRAAMEYMEQFDRDNDDLIENDGFPDQTYDTWTVHGVSAYCGCLWLAALQAAAAMA 648
++ + +A ME ++D+DND LIEN PDQTYD+W + G SAYC LWLAALQA +AMA
Sbjct: 691 MYASCKAIMERTIEYDKDNDGLIENTKMPDQTYDSWVMDGPSAYCSGLWLAALQAMSAMA 750
Query: 649 LQIGDKFFAELCKNKFLNAKAALEAKLWNGTYFNYDSGASSNSKSIQTDQLAGQWYTASS 828
+ ++ K +LE KLWNG+Y+ +D + S+ +I DQL G WY S
Sbjct: 751 TILDQPNDCLRYQDILEKGKRSLEEKLWNGSYYRFDL-SHSHRDTIMADQLCGHWYLKSC 809
Query: 829 GLP-PIFEDSKIKSTSQKIFDFNVMKTKGGRMGAVNGMHPD-------GKVDETCMQSRE 984
G I+ +++ ++I+D NVM G +GA NG + G VD + +Q+ E
Sbjct: 810 GFDYEIYPKENVRTALKRIYDNNVMGFHEGNIGAANGFIANASEPTKPGHVDNSNIQAEE 869
Query: 985 IWTGVTYAAAATMILSGMEEQGFTTAEGIFTAGWSEEGFGYWFQTPEGWTMDGHYRSLIY 1164
+W GV YA AATMI GM E+ F TA G++ + G F+TPE + YRS+ Y
Sbjct: 870 VWPGVVYALAATMIQEGMFEEAFQTAGGMYKT--LSQRIGMNFETPEALYGEKRYRSIGY 927
Query: 1165 MRPLAIWGMQWALSLPKAILD 1227
MRPL+IW MQ AL +A D
Sbjct: 928 MRPLSIWSMQVALERRRAQRD 948
Score = 126 bits (314), Expect = 8e-028
Identities = 63/112 (56%), Positives = 79/112 (70%), Gaps = 2/112 (1%)
Frame = +1
Query: 106 GRFLYLEGVEYVMWNTYDVHFYASYALLMLFPKIELNIQRDFAKAVLSEDGRKVKFLAEG 285
GRF YLEG EY M+NTYDVHFYAS AL L+P +++++Q DF A+ +E K L +G
Sbjct: 505 GRFGYLEGHEYRMYNTYDVHFYASPALAHLWPNLQVSLQYDFKDAIAAELNDTRKMLYDG 564
Query: 286 NLGIRKVRGAVPHDLGMHD--PWNEMNAYNIHDTSKWKDLNPKFVLQVYRDF 435
+ RKV+ VPHDLG D P+ +N YNIHD + WKDLN KFVLQVYRD+
Sbjct: 565 KVMPRKVKNCVPHDLGDPDEEPFTLINCYNIHDVNDWKDLNTKFVLQVYRDY 616
Database: UniProt/SwissProt
Posted date: Sat Aug 07 14:36:18 2010
Number of letters in database: 182,829,261
Number of sequences in database: 518,415
Lambda K H
0.267 0.041 0.140
Gapped
Lambda K H
0.267 0.041 0.140
Matrix: blosum62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 110,786,529,805
Number of Sequences: 518415
Number of Extensions: 110786529805
Number of Successful Extensions: 699577861
Number of sequences better than 0.0: 0
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