BLASTX 7.6.2
Query= UN27022 /QuerySize=1261
(1260 letters)
Database: UniProt/SwissProt;
518,415 sequences; 182,829,261 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q6IDS6|C3H35_ARATH E3 ubiquitin-protein ligase makorin OS=Ara... 470 2e-131
sp|Q5ZA07|C3H41_ORYSJ E3 ubiquitin-protein ligase makorin OS=Ory... 371 1e-101
sp|Q8JFF3|MKRN1_SERQU Probable E3 ubiquitin-protein ligase makor... 194 1e-048
sp|Q5NU14|MKRN1_TAKRU Probable E3 ubiquitin-protein ligase makor... 194 1e-048
sp|Q9ERV1|MKRN2_MOUSE Probable E3 ubiquitin-protein ligase makor... 194 1e-048
sp|Q9H000|MKRN2_HUMAN Probable E3 ubiquitin-protein ligase makor... 193 3e-048
sp|Q4VBT5|MKRN1_DANRE Probable E3 ubiquitin-protein ligase makor... 192 5e-048
sp|Q9QXP6|MKRN1_MOUSE E3 ubiquitin-protein ligase makorin-1 OS=M... 188 7e-047
sp|Q6GLT5|MKRN1_XENLA Probable E3 ubiquitin-protein ligase makor... 188 7e-047
sp|Q9TT91|MKRN1_MACEU E3 ubiquitin-protein ligase makorin-1 OS=M... 188 1e-046
sp|Q9UHC7|MKRN1_HUMAN E3 ubiquitin-protein ligase makorin-1 OS=H... 185 6e-046
sp|Q13434|MKRN4_HUMAN Putative E3 ubiquitin-protein ligase makor... 184 1e-045
sp|Q9DD48|MKRN2_SERQU Probable E3 ubiquitin-protein ligase makor... 183 4e-045
sp|Q9DFG8|MKRN2_DANRE Probable E3 ubiquitin-protein ligase makor... 182 5e-045
sp|B0F0H3|MKRN2_XENLA Probable E3 ubiquitin-protein ligase makor... 180 2e-044
sp|Q6GLD9|MKRN2_XENTR Probable E3 ubiquitin-protein ligase makor... 180 2e-044
sp|Q60764|MKRN3_MOUSE Probable E3 ubiquitin-protein ligase makor... 177 2e-043
sp|Q13064|MKRN3_HUMAN Probable E3 ubiquitin-protein ligase makor... 176 3e-043
sp|Q5NU13|MKRN2_TAKRU Probable E3 ubiquitin-protein ligase makor... 174 1e-042
>sp|Q6IDS6|C3H35_ARATH E3 ubiquitin-protein ligase makorin OS=Arabidopsis
thaliana GN=MKRN PE=2 SV=1
Length = 323
Score = 470 bits (1207), Expect = 2e-131
Identities = 214/320 (66%), Positives = 254/320 (79%), Gaps = 13/320 (4%)
Frame = +3
Query: 270 MSKRILCKFFAHGACLKGDNCEFSHDWKDPSNNICTFYQRGNCSYGSRCRYEHVKPSRPP 449
MS RILCKFF HG+CLKG+NCEFSHD KDP NN+CTFYQ+ C YGSRCRY+HV+ +
Sbjct: 1 MSDRILCKFFVHGSCLKGENCEFSHDSKDPPNNVCTFYQKRICLYGSRCRYDHVRAASNL 60
Query: 450 PASSSALLPPGTYLSSERGLTSAPSASSPPPPAWTLDSLDDQANNNNNTGPTNPEDKPIC 629
P SS + S +R +++ PS ++ + ++N +P + PIC
Sbjct: 61 PLSSDS-------ESLDRSISTTPSRHLQQ------QGDNNDGDKSSNVYCIHPREYPIC 107
Query: 630 SYAAAGDCPRGDQCPHIHGDLCPTCGKRCLHPFRPEEREDHKKACEKKHKQLEALKLSQD 809
S+AAAGDCPRG+QCPH+HGDLC TCGK+CLHPFRPEERE+H K CEKK K +EALK SQD
Sbjct: 108 SFAAAGDCPRGNQCPHMHGDLCNTCGKKCLHPFRPEEREEHTKECEKKQKHIEALKQSQD 167
Query: 810 VECCVCLERVLSKPTPAERKFGLLTECDHAFCIGCIRNWRSSSPSTGMDVNSTLRACPIC 989
+EC VCL+R+LSK TP ERKFGLLTECDH FCI CIRNWRSS+P +GMDVNSTLRACPIC
Sbjct: 168 IECSVCLDRILSKATPGERKFGLLTECDHPFCIQCIRNWRSSAPVSGMDVNSTLRACPIC 227
Query: 990 RKLSYFVVPSVIWFSDPEEKKEIMDNYRDKLRSIDCKHFNFGDGNCPFGTSCFYKHAFHD 1169
RKLSYFVVPSV+W+S PEEKKEI+D Y+ KLRSIDCKHFNFG+GNCPFG SCFYKHA+ D
Sbjct: 228 RKLSYFVVPSVVWYSSPEEKKEIIDIYKAKLRSIDCKHFNFGNGNCPFGASCFYKHAYSD 287
Query: 1170 GRLEEVVLRHLDAEDGQTVI 1229
G LEEVVLRHL +++G+TVI
Sbjct: 288 GHLEEVVLRHLGSQEGETVI 307
Score = 389 bits (999), Expect = 2e-107
Identities = 175/237 (73%), Positives = 201/237 (84%), Gaps = 5/237 (2%)
Frame = +3
Query: 564 LDDQANNNNNTGPTN-----PEDKPICSYAAAGDCPRGDQCPHIHGDLCPTCGKRCLHPF 728
L Q +NN+ +N P + PICS+AAAGDCPRG+QCPH+HGDLC TCGK+CLHPF
Sbjct: 81 LQQQGDNNDGDKSSNVYCIHPREYPICSFAAAGDCPRGNQCPHMHGDLCNTCGKKCLHPF 140
Query: 729 RPEEREDHKKACEKKHKQLEALKLSQDVECCVCLERVLSKPTPAERKFGLLTECDHAFCI 908
RPEERE+H K CEKK K +EALK SQD+EC VCL+R+LSK TP ERKFGLLTECDH FCI
Sbjct: 141 RPEEREEHTKECEKKQKHIEALKQSQDIECSVCLDRILSKATPGERKFGLLTECDHPFCI 200
Query: 909 GCIRNWRSSSPSTGMDVNSTLRACPICRKLSYFVVPSVIWFSDPEEKKEIMDNYRDKLRS 1088
CIRNWRSS+P +GMDVNSTLRACPICRKLSYFVVPSV+W+S PEEKKEI+D Y+ KLRS
Sbjct: 201 QCIRNWRSSAPVSGMDVNSTLRACPICRKLSYFVVPSVVWYSSPEEKKEIIDIYKAKLRS 260
Query: 1089 IDCKHFNFGDGNCPFGTSCFYKHAFHDGRLEEVVLRHLDAEDGQTVIAKEIRLSDFL 1259
IDCKHFNFG+GNCPFG SCFYKHA+ DG LEEVVLRHL +++G+TVI IRLS+FL
Sbjct: 261 IDCKHFNFGNGNCPFGASCFYKHAYSDGHLEEVVLRHLGSQEGETVITDSIRLSEFL 317
>sp|Q5ZA07|C3H41_ORYSJ E3 ubiquitin-protein ligase makorin OS=Oryza sativa
subsp. japonica GN=MKRN PE=2 SV=1
Length = 368
Score = 371 bits (950), Expect = 1e-101
Identities = 161/223 (72%), Positives = 193/223 (86%)
Frame = +3
Query: 591 NTGPTNPEDKPICSYAAAGDCPRGDQCPHIHGDLCPTCGKRCLHPFRPEEREDHKKACEK 770
N +P D PICS+AA G+CP G++CP +HGDLC TCGK CLHP+RP+ERE+H K CEK
Sbjct: 141 NQTTLSPADLPICSFAAGGNCPYGEECPQMHGDLCTTCGKMCLHPYRPDEREEHTKLCEK 200
Query: 771 KHKQLEALKLSQDVECCVCLERVLSKPTPAERKFGLLTECDHAFCIGCIRNWRSSSPSTG 950
HK+LE+LK SQ++EC VCL+RVLSKPT AERKFGLL+ECDH FCI CIRNWR++SP++G
Sbjct: 201 NHKRLESLKRSQEIECSVCLDRVLSKPTAAERKFGLLSECDHPFCISCIRNWRNNSPTSG 260
Query: 951 MDVNSTLRACPICRKLSYFVVPSVIWFSDPEEKKEIMDNYRDKLRSIDCKHFNFGDGNCP 1130
MDVNS LRACPICRKLSY+V+PSV+W+ EEK EI+DNY+ KL+SIDCK+F+FG G CP
Sbjct: 261 MDVNSALRACPICRKLSYYVIPSVLWYFSKEEKLEIIDNYKAKLKSIDCKYFDFGTGTCP 320
Query: 1131 FGTSCFYKHAFHDGRLEEVVLRHLDAEDGQTVIAKEIRLSDFL 1259
FG+SCFYKHA+ DGRLEEV+LRHLDA+DG TVIAK IRLSDFL
Sbjct: 321 FGSSCFYKHAYRDGRLEEVILRHLDADDGSTVIAKNIRLSDFL 363
>sp|Q8JFF3|MKRN1_SERQU Probable E3 ubiquitin-protein ligase makorin-1 OS=Seriola
quinqueradiata GN=mkrn1 PE=2 SV=1
Length = 435
Score = 194 bits (492), Expect = 1e-048
Identities = 86/193 (44%), Positives = 126/193 (65%), Gaps = 8/193 (4%)
Frame = +3
Query: 618 KPICSYAAAGDCPRGDQCPHIHGDLCPTCGKRCLHPFRPEEREDHKKACEKKH-KQLE-- 788
K +C YAA G+C G C ++HGD+C CG + LHP +R +H KAC + H K +E
Sbjct: 158 KQLCPYAAVGECRYGINCAYLHGDVCYMCGLQVLHPTDNNQRSEHTKACIEAHEKDMEIS 217
Query: 789 -ALKLSQDVECCVCLERVLSKPTPAERKFGLLTECDHAFCIGCIRNWRSSSPSTGMDVNS 965
A++ S+D+ C VC+E V K P+ER+FG+L+ C H +C+ CIR WRS+ +
Sbjct: 218 FAIQRSKDMMCGVCMEVVFEKANPSERRFGILSNCSHCYCLKCIRKWRSAKQFE----SK 273
Query: 966 TLRACPICRKLSYFVVPSVIWFSDPEEKKEIMDNYRDKLRSIDCKHFNFGDGNCPFGTSC 1145
+++CP CR S FV+PS W D ++K++++ Y+D + S C++F+ G G CPFG++C
Sbjct: 274 IIKSCPECRITSNFVIPSEYWVEDKDDKQKLIQKYKDGMGSKPCRYFDEGRGTCPFGSNC 333
Query: 1146 FYKHAFHDGRLEE 1184
FYKHAF DGRLEE
Sbjct: 334 FYKHAFPDGRLEE 346
>sp|Q5NU14|MKRN1_TAKRU Probable E3 ubiquitin-protein ligase makorin-1
OS=Takifugu rubripes GN=mkrn1 PE=2 SV=1
Length = 429
Score = 194 bits (492), Expect = 1e-048
Identities = 89/205 (43%), Positives = 129/205 (62%), Gaps = 10/205 (4%)
Frame = +3
Query: 588 NNTGPTNPED--KPICSYAAAGDCPRGDQCPHIHGDLCPTCGKRCLHPFRPEEREDHKKA 761
N T+ E+ K +C YAA G+C G C ++HGD+C CG + LHP +R +H KA
Sbjct: 144 NGDATTDKEELRKQLCPYAAVGECRYGVNCAYLHGDVCDMCGLQVLHPTDSSQRSEHTKA 203
Query: 762 CEKKH-KQLE---ALKLSQDVECCVCLERVLSKPTPAERKFGLLTECDHAFCIGCIRNWR 929
C + H K +E A++ S+D+ C VC+E V K P+ER+FG+L+ C H +C+ CIR WR
Sbjct: 204 CIEAHEKDMEISFAIQRSKDMMCGVCMEVVFEKANPSERRFGILSNCSHCYCLKCIRKWR 263
Query: 930 SSSPSTGMDVNSTLRACPICRKLSYFVVPSVIWFSDPEEKKEIMDNYRDKLRSIDCKHFN 1109
S+ + +++CP CR S FV+PS W D E+K++++ Y+D + C++F+
Sbjct: 264 SAKQFE----SKIIKSCPECRITSNFVIPSEYWVEDKEDKQKLIQKYKDGMGRKPCRYFD 319
Query: 1110 FGDGNCPFGTSCFYKHAFHDGRLEE 1184
G G CPFG +CFYKHAF DGRLEE
Sbjct: 320 EGRGICPFGANCFYKHAFPDGRLEE 344
>sp|Q9ERV1|MKRN2_MOUSE Probable E3 ubiquitin-protein ligase makorin-2 OS=Mus
musculus GN=Mkrn2 PE=2 SV=1
Length = 416
Score = 194 bits (492), Expect = 1e-048
Identities = 99/262 (37%), Positives = 149/262 (56%), Gaps = 20/262 (7%)
Frame = +3
Query: 504 GLTSAPSASSPPPPAWTLDS----LDD-QANNNNNTGPTNPEDKPICSYAAAGDCPRGDQ 668
G S P S P LD+ LDD +A+++ + P +C YAAAG+C GD
Sbjct: 131 GGCSDPQTSPEMKPHSYLDAIRTGLDDLEASSSYSNEP------QLCPYAAAGECRLGDA 184
Query: 669 CPHIHGDLCPTCGKRCLHPFRPEEREDHKKAC----EKKHKQLEALKLSQDVECCVCLER 836
C ++HGD+C C + LHPF PE+R+ H+K C E + ++ A + SQD C +C+E
Sbjct: 185 CVYLHGDMCEICRLQVLHPFDPEQRKAHEKMCMSTFEHEMEKAFAFQASQDKVCSICMEV 244
Query: 837 VLSKPTPAERKFGLLTECDHAFCIGCIRNWRSSSPSTGMDVNSTLRACPICRKLSYFVVP 1016
+L K + +ER+FG+L+ C H +C+ CIR WR + N +++CP CR +S FV+P
Sbjct: 245 ILEKASASERRFGILSNCSHTYCLSCIRQWRCAKQFE----NPIIKSCPECRVISEFVIP 300
Query: 1017 SVIWFSDPEEKKEIMDNYRDKLRSIDCKHFNFGDGNCPFGTSCFYKHAFHDGRLEEVVL- 1193
SV W D +K E+++ ++ + CK+F G G CPFG+ C Y+HA+ DGRL E
Sbjct: 301 SVYWVEDQNKKNELIEAFKQGMGKKACKYFEQGKGTCPFGSKCLYRHAYPDGRLAEPEKP 360
Query: 1194 RHLDAEDGQTVIAKEIRLSDFL 1259
R + +G +RL DF+
Sbjct: 361 RKQLSSEGTVRFFNSVRLWDFI 382
>sp|Q9H000|MKRN2_HUMAN Probable E3 ubiquitin-protein ligase makorin-2 OS=Homo
sapiens GN=MKRN2 PE=1 SV=2
Length = 416
Score = 193 bits (489), Expect = 3e-048
Identities = 95/260 (36%), Positives = 147/260 (56%), Gaps = 10/260 (3%)
Frame = +3
Query: 495 SERGLTSAPSASSPPPPAWTLDSLDDQANNNNNTGPTNPEDKPICSYAAAGDCPRGDQCP 674
S G S P S P LD++ ++ + + E + +C YAAAG+C GD C
Sbjct: 128 SNPGSCSDPQPSPEMKPHSYLDAIRSGLDDVEASSSYSNEQQ-LCPYAAAGECRFGDACV 186
Query: 675 HIHGDLCPTCGKRCLHPFRPEEREDHKKAC----EKKHKQLEALKLSQDVECCVCLERVL 842
++HG++C C + LHPF PE+R+ H+K C E + ++ A + SQD C +C+E +L
Sbjct: 187 YLHGEVCEICRLQVLHPFDPEQRKAHEKICMLTFEHEMEKAFAFQASQDKVCSICMEVIL 246
Query: 843 SKPTPAERKFGLLTECDHAFCIGCIRNWRSSSPSTGMDVNSTLRACPICRKLSYFVVPSV 1022
K + +ER+FG+L+ C+H +C+ CIR WR + N +++CP CR +S FV+PSV
Sbjct: 247 EKASASERRFGILSNCNHTYCLSCIRQWRCAKQFE----NPIIKSCPECRVISEFVIPSV 302
Query: 1023 IWFSDPEEKKEIMDNYRDKLRSIDCKHFNFGDGNCPFGTSCFYKHAFHDGRLEEVVL-RH 1199
W D +K E+++ ++ + CK+F G G CPFG+ C Y+HA+ DGRL E R
Sbjct: 303 YWVEDQNKKNELIEAFKQGMGKKACKYFEQGKGTCPFGSKCLYRHAYPDGRLAEPEKPRK 362
Query: 1200 LDAEDGQTVIAKEIRLSDFL 1259
+ G +RL DF+
Sbjct: 363 QLSSQGTVRFFNSVRLWDFI 382
>sp|Q4VBT5|MKRN1_DANRE Probable E3 ubiquitin-protein ligase makorin-1 OS=Danio
rerio GN=mkrn1 PE=2 SV=1
Length = 439
Score = 192 bits (487), Expect = 5e-048
Identities = 86/193 (44%), Positives = 124/193 (64%), Gaps = 8/193 (4%)
Frame = +3
Query: 618 KPICSYAAAGDCPRGDQCPHIHGDLCPTCGKRCLHPFRPEEREDHKKACEKKH-KQLE-- 788
K +C YAA G+C G C ++HGD+C CG + LHP +R H +AC + H K +E
Sbjct: 166 KQLCPYAAVGECRYGLNCAYLHGDVCDMCGLQVLHPSDTSQRSQHIRACIEAHEKDMEIS 225
Query: 789 -ALKLSQDVECCVCLERVLSKPTPAERKFGLLTECDHAFCIGCIRNWRSSSPSTGMDVNS 965
A++ S+D+ C VC+E V K P+ER+FG+L+ C H +C+ CIR WRS+ +
Sbjct: 226 FAIQRSKDMMCGVCMEVVFEKTNPSERRFGILSNCCHCYCLKCIRKWRSAKQFE----SK 281
Query: 966 TLRACPICRKLSYFVVPSVIWFSDPEEKKEIMDNYRDKLRSIDCKHFNFGDGNCPFGTSC 1145
+++CP CR S FV+PS W D EEK++++ Y+D + + C++F+ G G CPFG +C
Sbjct: 282 IIKSCPECRITSNFVIPSEYWVEDKEEKQQLIQKYKDGMGTKPCRYFDEGRGTCPFGANC 341
Query: 1146 FYKHAFHDGRLEE 1184
FYKHAF DGRLEE
Sbjct: 342 FYKHAFPDGRLEE 354
>sp|Q9QXP6|MKRN1_MOUSE E3 ubiquitin-protein ligase makorin-1 OS=Mus musculus
GN=Mkrn1 PE=2 SV=1
Length = 481
Score = 188 bits (477), Expect = 7e-047
Identities = 88/229 (38%), Positives = 136/229 (59%), Gaps = 16/229 (6%)
Frame = +3
Query: 513 SAPSASSPPPPAWTLDSLDDQANNNNNTGPTNPE-DKPICSYAAAGDCPRGDQCPHIHGD 689
+APS + PP + PT E K +C YAA G+C G+ C ++HGD
Sbjct: 182 TAPSCTEVPPQG-------SVTKEESEKEPTTVETKKQLCPYAAVGECRYGENCVYLHGD 234
Query: 690 LCPTCGKRCLHPFRPEEREDHKKACEKKH-KQLE---ALKLSQDVECCVCLERVLSKPTP 857
C CG + LHP +R H K+C + H K +E A++ ++D+ C +C+E V K P
Sbjct: 235 SCDMCGLQVLHPVDAAQRSQHIKSCIEAHEKDMELSFAVQRTKDMVCGICMEVVYEKANP 294
Query: 858 AERKFGLLTECDHAFCIGCIRNWRSSSPSTGMDVNSTLRACPICRKLSYFVVPSVIWFSD 1037
+ER+FG+L+ C+H +C+ CIR WRS+ + +++CP CR S FV+PS W +
Sbjct: 295 SERRFGILSNCNHTYCLKCIRKWRSAKQFE----SKIIKSCPECRITSNFVIPSEYWVEE 350
Query: 1038 PEEKKEIMDNYRDKLRSIDCKHFNFGDGNCPFGTSCFYKHAFHDGRLEE 1184
EEK++++ Y++ + + C++F+ G G+CPFG +CFYKHA+ DGR EE
Sbjct: 351 KEEKQKLIQKYKEAMSNKACRYFDEGRGSCPFGGNCFYKHAYPDGRREE 399
>sp|Q6GLT5|MKRN1_XENLA Probable E3 ubiquitin-protein ligase makorin-1 OS=Xenopus
laevis GN=mkrn1 PE=2 SV=1
Length = 408
Score = 188 bits (477), Expect = 7e-047
Identities = 83/200 (41%), Positives = 128/200 (64%), Gaps = 9/200 (4%)
Frame = +3
Query: 600 PTNPE-DKPICSYAAAGDCPRGDQCPHIHGDLCPTCGKRCLHPFRPEEREDHKKACEKKH 776
P +PE K +C YAA G+C G+ C ++HGD C CG + LHP +R H K+C + H
Sbjct: 170 PADPELKKQLCPYAAMGECRYGENCVYLHGDPCDMCGLQVLHPVDTCQRSQHIKSCIEAH 229
Query: 777 -KQLE---ALKLSQDVECCVCLERVLSKPTPAERKFGLLTECDHAFCIGCIRNWRSSSPS 944
K +E A++ S+D+ C +C+E V K P+ER+FG+L+ C H++C+ CIR WRS+
Sbjct: 230 EKDMELSFAVQRSKDIVCGICMEVVYEKTNPSERRFGILSNCSHSYCLKCIRKWRSAKQF 289
Query: 945 TGMDVNSTLRACPICRKLSYFVVPSVIWFSDPEEKKEIMDNYRDKLRSIDCKHFNFGDGN 1124
+ +++CP CR S F++PS W + EEK +++ Y++ + S C++F+ G G
Sbjct: 290 E----SKIIKSCPECRITSNFIIPSEYWVEEKEEKHKLIHKYKEAMSSKSCRYFDEGRGT 345
Query: 1125 CPFGTSCFYKHAFHDGRLEE 1184
CPFG +CFY+HA+ DGR+EE
Sbjct: 346 CPFGGNCFYRHAYPDGRIEE 365
>sp|Q9TT91|MKRN1_MACEU E3 ubiquitin-protein ligase makorin-1 OS=Macropus eugenii
GN=MKRN1 PE=2 SV=1
Length = 478
Score = 188 bits (475), Expect = 1e-046
Identities = 88/229 (38%), Positives = 137/229 (59%), Gaps = 16/229 (6%)
Frame = +3
Query: 513 SAPSASSPPPPAWTL-DSLDDQANNNNNTGPTNPEDKPICSYAAAGDCPRGDQCPHIHGD 689
+APS + P + + L+ Q N K +C YAA G+C G+ C ++HGD
Sbjct: 178 AAPSCTEAPLQGMVIEEELEKQQTNVE-------MKKQLCPYAAVGECRYGENCVYLHGD 230
Query: 690 LCPTCGKRCLHPFRPEEREDHKKACEKKH-KQLE---ALKLSQDVECCVCLERVLSKPTP 857
C CG + LHP +R H K+C + H K +E A++ S+D+ C +C+E V K P
Sbjct: 231 ACDMCGLQVLHPVDAAQRSQHIKSCIEAHEKDMELSFAVQRSKDMVCGICMEVVYEKANP 290
Query: 858 AERKFGLLTECDHAFCIGCIRNWRSSSPSTGMDVNSTLRACPICRKLSYFVVPSVIWFSD 1037
+ER+FG+L+ C+H +C+ CIR WRS+ + +++CP CR S FV+PS W +
Sbjct: 291 SERRFGILSNCNHTYCLKCIRKWRSAKQFE----SKIIKSCPECRITSNFVIPSEYWVEE 346
Query: 1038 PEEKKEIMDNYRDKLRSIDCKHFNFGDGNCPFGTSCFYKHAFHDGRLEE 1184
EEK++++ Y++ + + C++F+ G G+CPFG +CFYKHA+ DGR EE
Sbjct: 347 KEEKQKLIQKYKEAMSNKPCRYFDEGRGSCPFGGNCFYKHAYPDGRREE 395
>sp|Q9UHC7|MKRN1_HUMAN E3 ubiquitin-protein ligase makorin-1 OS=Homo sapiens
GN=MKRN1 PE=1 SV=3
Length = 482
Score = 185 bits (469), Expect = 6e-046
Identities = 81/193 (41%), Positives = 125/193 (64%), Gaps = 8/193 (4%)
Frame = +3
Query: 618 KPICSYAAAGDCPRGDQCPHIHGDLCPTCGKRCLHPFRPEEREDHKKACEKKH-KQLE-- 788
K +C YAA G+C G+ C ++HGD C CG + LHP +R H K+C + H K +E
Sbjct: 211 KQLCPYAAVGECRYGENCVYLHGDSCDMCGLQVLHPMDAAQRSQHIKSCIEAHEKDMELS 270
Query: 789 -ALKLSQDVECCVCLERVLSKPTPAERKFGLLTECDHAFCIGCIRNWRSSSPSTGMDVNS 965
A++ S+D+ C +C+E V K P+ER+FG+L+ C+H +C+ CIR WRS+ +
Sbjct: 271 FAVQRSKDMVCGICMEVVYEKANPSERRFGILSNCNHTYCLKCIRKWRSAKQFE----SK 326
Query: 966 TLRACPICRKLSYFVVPSVIWFSDPEEKKEIMDNYRDKLRSIDCKHFNFGDGNCPFGTSC 1145
+++CP CR S FV+PS W + EEK++++ Y++ + + C++F+ G G+CPFG +C
Sbjct: 327 IIKSCPECRITSNFVIPSEYWVEEKEEKQKLILKYKEAMSNKACRYFDEGRGSCPFGGNC 386
Query: 1146 FYKHAFHDGRLEE 1184
FYKHA+ DGR EE
Sbjct: 387 FYKHAYPDGRREE 399
>sp|Q13434|MKRN4_HUMAN Putative E3 ubiquitin-protein ligase makorin-4 OS=Homo
sapiens GN=MKRN4P PE=5 SV=1
Length = 485
Score = 184 bits (466), Expect = 1e-045
Identities = 84/193 (43%), Positives = 119/193 (61%), Gaps = 8/193 (4%)
Frame = +3
Query: 618 KPICSYAAAGDCPRGDQCPHIHGDLCPTCGKRCLHPFRPEEREDHKKACEKKH-KQLE-- 788
K +C YAA G C G+ C ++HGDLC CG + LHP +R H +AC + H K +E
Sbjct: 246 KQLCPYAAVGQCRYGENCVYLHGDLCDMCGLQVLHPMDAAQRSQHIQACIEAHEKDMEFS 305
Query: 789 -ALKLSQDVECCVCLERVLSKPTPAERKFGLLTECDHAFCIGCIRNWRSSSPSTGMDVNS 965
A++ S+D C +C+E V K P E +FG+L+ C+H FC+ CIR WRS+ V S
Sbjct: 306 FAVQRSKDKVCGICMEVVYEKANPNEHRFGILSNCNHTFCLKCIRKWRSAKEFESRIVKS 365
Query: 966 TLRACPICRKLSYFVVPSVIWFSDPEEKKEIMDNYRDKLRSIDCKHFNFGDGNCPFGTSC 1145
CP CR S FV+PS W + EEK++++ Y++ + + CK+F+ G G+CPFG +C
Sbjct: 366 ----CPQCRITSNFVIPSEYWVEEKEEKQKLIQKYKEAMSNKACKYFDEGRGSCPFGENC 421
Query: 1146 FYKHAFHDGRLEE 1184
FYKH + DGR EE
Sbjct: 422 FYKHMYPDGRREE 434
>sp|Q9DD48|MKRN2_SERQU Probable E3 ubiquitin-protein ligase makorin-2 OS=Seriola
quinqueradiata GN=mkrn2 PE=2 SV=1
Length = 423
Score = 183 bits (462), Expect = 4e-045
Identities = 87/217 (40%), Positives = 127/217 (58%), Gaps = 9/217 (4%)
Frame = +3
Query: 624 ICSYAAAGDCPRGDQCPHIHGDLCPTCGKRCLHPFRPEEREDHKKAC----EKKHKQLEA 791
+C YAA G C + C ++HGDLC CG + LHP E+R H+K C E ++ A
Sbjct: 167 LCPYAANGHCFYEENCTYLHGDLCEVCGLQVLHPHDSEQRRAHEKMCLAAFEADMEKAFA 226
Query: 792 LKLSQDVECCVCLERVLSKPTPAERKFGLLTECDHAFCIGCIRNWRSSSPSTGMDVNSTL 971
+LSQD C +C+E V+ K P++R+FG+L+ C H FC+ CIR WR + + N+ +
Sbjct: 227 AQLSQDKVCSICMEVVVQKANPSDRRFGILSSCCHTFCLACIRKWRCTRTFS----NTII 282
Query: 972 RACPICRKLSYFVVPSVIWFSDPEEKKEIMDNYRDKLRSIDCKHFNFGDGNCPFGTSCFY 1151
++CP CR +S FV+PSV W D E+K ++D ++ + CK+F+ G G+CPFG C Y
Sbjct: 283 KSCPECRVVSEFVIPSVYWVEDQEDKDHLIDLFKSGVSKKACKYFDQGRGSCPFGGKCLY 342
Query: 1152 KHAFHDG-RLEEVVLRHLDAEDGQTVIAKEIRLSDFL 1259
HAF DG R E R + +G +RL DF+
Sbjct: 343 LHAFPDGTRAEPDRPRKQLSSEGNVRFMNSVRLWDFI 379
>sp|Q9DFG8|MKRN2_DANRE Probable E3 ubiquitin-protein ligase makorin-2 OS=Danio
rerio GN=mkrn2 PE=2 SV=2
Length = 414
Score = 182 bits (461), Expect = 5e-045
Identities = 88/225 (39%), Positives = 130/225 (57%), Gaps = 14/225 (6%)
Frame = +3
Query: 603 TNPEDKPICSYAAAGDCPRGDQCPHIHGDLCPTCGKRCLHPFRPEEREDHKKAC----EK 770
T+P+ IC + AAG C G+ CP++HG++C C + LHP PE+R H+K C E
Sbjct: 165 TSPQ---ICPFLAAGQCQYGESCPYLHGEMCEICRQHVLHPHDPEQRAAHEKKCMVAFEM 221
Query: 771 KHKQLEALKLSQDVECCVCLERVLSKPTPAERKFGLLTECDHAFCIGCIRNWRSSSPSTG 950
++ A++ SQD C +CL+ V K +P+ER+FG+L+ C H +C+ CIR WR
Sbjct: 222 DMERAFAVQQSQDKVCKICLDVVYEKSSPSERRFGILSSCAHTYCLNCIRQWRCVEQLH- 280
Query: 951 MDVNSTLRACPICRKLSYFVVPSVIWFSDPEEKKEIMDNYRDKLRSIDCKHFNFGDGNCP 1130
N ++CP CR +S FV+PS+ W D E+K +++ ++ + CK+F+ G G CP
Sbjct: 281 ---NQIRKSCPECRVVSEFVIPSIYWVEDQEQKNLLIEEFKSGVSKKACKYFDQGRGTCP 337
Query: 1131 FGTSCFYKHAFHDGRLEE--VVLRHLDAEDGQTVIAKEIRLSDFL 1259
FG CFY HA+ DGR E + L AE G +RL DF+
Sbjct: 338 FGGKCFYMHAYADGRRAEPDKPRKQLSAE-GNVRFQNSVRLWDFI 381
>sp|B0F0H3|MKRN2_XENLA Probable E3 ubiquitin-protein ligase makorin-2 OS=Xenopus
laevis GN=mkrn2 PE=2 SV=2
Length = 409
Score = 180 bits (456), Expect = 2e-044
Identities = 95/274 (34%), Positives = 143/274 (52%), Gaps = 16/274 (5%)
Frame = +3
Query: 453 ASSSALLPPGTYLSSERGLTSAPSASSPPPPAWTLDSLDDQANNNNNTGPTNPEDKPICS 632
AS L PG S+ A S LD D A+ P P+ +C
Sbjct: 112 ASVDPALQPGCITESQGSEGEAKPHSYLEAICTGLDESQDPASY-----PGAPQQ--LCP 164
Query: 633 YAAAGDCPRGDQCPHIHGDLCPTCGKRCLHPFRPEEREDHKKAC----EKKHKQLEALKL 800
+A AG+C GD CP++HGD C CG + LHP E+R DH+K C E ++ A++
Sbjct: 165 FAQAGECHCGDSCPYLHGDACEICGLQVLHPHDQEQRRDHEKLCMENFELDMERAFAVQA 224
Query: 801 SQDVECCVCLERVLSKPTPAERKFGLLTECDHAFCIGCIRNWRSSSPSTGMDVNSTLRAC 980
S+ C +C+ERV K +PA+R+F +L++C+H +C+ CIR WR + N +++C
Sbjct: 225 SEGRVCSICMERVYEKQSPAQRRFRILSDCNHTYCLTCIRQWRCARQFD----NPVIKSC 280
Query: 981 PICRKLSYFVVPSVIWFSDPEEKKEIMDNYRDKLRSIDCKHFNFGDGNCPFGTSCFYKHA 1160
P CR +S FV+PS W D +K E+++ ++ + CK+F+ G G CPFG C Y H+
Sbjct: 281 PECRVISEFVIPSAYWVEDQSKKDELIEAFKQGMGKKLCKYFDQGRGTCPFGGKCLYLHS 340
Query: 1161 FHDG-RLEEVVLRHLDAEDGQTVIAKEIRLSDFL 1259
+ DG R + R +G +RL DF+
Sbjct: 341 YPDGTRAQPEKPRKQLGSEGSVRFLNSLRLWDFI 374
>sp|Q6GLD9|MKRN2_XENTR Probable E3 ubiquitin-protein ligase makorin-2 OS=Xenopus
tropicalis GN=mkrn2 PE=2 SV=1
Length = 418
Score = 180 bits (456), Expect = 2e-044
Identities = 85/227 (37%), Positives = 129/227 (56%), Gaps = 11/227 (4%)
Frame = +3
Query: 600 PTNPEDKP--ICSYAAAGDCPRGDQCPHIHGDLCPTCGKRCLHPFRPEEREDHKKAC--- 764
P+ D P +C +A AG C G+ CP+IHG++C CG + LHP+ E+R H+K C
Sbjct: 159 PSAYPDAPQQLCPFAQAGGCHYGESCPYIHGNVCEICGLQVLHPYDQEQRGHHEKLCMAN 218
Query: 765 -EKKHKQLEALKLSQDVECCVCLERVLSKPTPAERKFGLLTECDHAFCIGCIRNWRSSSP 941
E+ ++ A + S+ C +C+ERV K +P+ER+FG+L+ C H +C+ CIR WR +
Sbjct: 219 FERDMERAFAFQASEGKVCSICMERVYDKQSPSERRFGILSNCHHTYCLACIRQWRCARQ 278
Query: 942 STGMDVNSTLRACPICRKLSYFVVPSVIWFSDPEEKKEIMDNYRDKLRSIDCKHFNFGDG 1121
N +++CP CR +S FV+PS W D +K E+++ ++ + CK+F+ G G
Sbjct: 279 FE----NPVIKSCPECRVISEFVIPSAYWVEDQSKKFELIEAFKQGMGKKACKYFDQGRG 334
Query: 1122 NCPFGTSCFYKHAFHDG-RLEEVVLRHLDAEDGQTVIAKEIRLSDFL 1259
CPFG C Y HA+ DG R E R +G +RL DF+
Sbjct: 335 TCPFGGKCLYLHAYPDGTRAEPEKPRKQLGSEGTVRFLNSVRLWDFI 381
>sp|Q60764|MKRN3_MOUSE Probable E3 ubiquitin-protein ligase makorin-3 OS=Mus
musculus GN=Mkrn3 PE=2 SV=1
Length = 544
Score = 177 bits (447), Expect = 2e-043
Identities = 77/192 (40%), Positives = 120/192 (62%), Gaps = 8/192 (4%)
Frame = +3
Query: 609 PEDKPICSYAAAGDCPRGDQCPHIHGDLCPTCGKRCLHPFRPEEREDHKKACEKKH-KQL 785
P P+C YAA G C RGD+C + HG++C CG++ LHP+ ++E H++AC + H + +
Sbjct: 274 PMPLPLCRYAARGQCLRGDRCAYPHGEICDMCGQQALHPWDAAQQEAHRRACVEAHERDM 333
Query: 786 E---ALKLSQDVECCVCLERVLSKPTPAERKFGLLTECDHAFCIGCIRNWRSSSPSTGMD 956
E A++ S D C +C+E V K P +R+FG+L C+H +C+ CIR WRS++
Sbjct: 334 ELSFAVQRSMDKVCGICMEVVYEKADPTDRRFGILFSCNHTYCLRCIRRWRSATQFE--- 390
Query: 957 VNSTLRACPICRKLSYFVVPSVIWFSDPEEKKEIMDNYRDKLRSIDCKHFNFGDGNCPFG 1136
N ++CP CR S FV+PS W + EEK++++ Y++ + C++F G G+CPFG
Sbjct: 391 -NRISKSCPQCRVSSGFVIPSEFWVEEEEEKEKLVQQYKEGMSQKACRYFAGGLGHCPFG 449
Query: 1137 TSCFYKHAFHDG 1172
CFYKH + +G
Sbjct: 450 EFCFYKHEYPEG 461
>sp|Q13064|MKRN3_HUMAN Probable E3 ubiquitin-protein ligase makorin-3 OS=Homo
sapiens GN=MKRN3 PE=1 SV=1
Length = 507
Score = 176 bits (446), Expect = 3e-043
Identities = 77/186 (41%), Positives = 117/186 (62%), Gaps = 8/186 (4%)
Frame = +3
Query: 627 CSYAAAGDCPRGDQCPHIHGDLCPTCGKRCLHPFRPEEREDHKKACEKKH-KQLE---AL 794
C YA+ G C RG+ C ++HGD+C CG + LHP +RE+H +AC + H K +E A+
Sbjct: 244 CYYASRGVCFRGESCMYLHGDICDMCGLQTLHPMDAAQREEHMRACIEAHEKDMELSFAV 303
Query: 795 KLSQDVECCVCLERVLSKPTPAERKFGLLTECDHAFCIGCIRNWRSSSPSTGMDVNSTLR 974
+ D C +C+E V K P +R+FG+L+ C+H+FCI CIR WRS+ N ++
Sbjct: 304 QRGMDKVCGICMEVVYEKANPNDRRFGILSNCNHSFCIRCIRRWRSARQFE----NRIVK 359
Query: 975 ACPICRKLSYFVVPSVIWFSDPEEKKEIMDNYRDKLRSIDCKHFNFGDGNCPFGTSCFYK 1154
+CP CR S V+PS W + EEK++++ Y++ + + C++F G GNCPFG +CFYK
Sbjct: 360 SCPQCRVTSELVIPSEFWVEEEEEKQKLIQQYKEAMSNKACRYFAEGRGNCPFGDTCFYK 419
Query: 1155 HAFHDG 1172
H + +G
Sbjct: 420 HEYPEG 425
>sp|Q5NU13|MKRN2_TAKRU Probable E3 ubiquitin-protein ligase makorin-2
OS=Takifugu rubripes GN=mkrn2 PE=2 SV=1
Length = 402
Score = 174 bits (440), Expect = 1e-042
Identities = 95/276 (34%), Positives = 149/276 (53%), Gaps = 21/276 (7%)
Frame = +3
Query: 483 TYLSSER-GLTSAPSAS-----SPPPPAWTLDSLDD--QANNNNNTGPT----NPEDKPI 626
T++ ER + AP+ S P P +D++ +++ ++T PT N + +
Sbjct: 87 TFVHQERENMFRAPAESFGADVMAPAPHTYVDAIRTGLSSSSQDHTPPTMAGVNQDLPRL 146
Query: 627 CSYAAAGDCPRGDQCPHIHGDLCPTCGKRCLHPFRPEEREDHKKAC----EKKHKQLEAL 794
C YAA G C + C ++HGD C CG + L P PE+R H+K C E ++ A+
Sbjct: 147 CPYAAVGHCYYEENCIYLHGDKCEVCGLQVLDPHNPEQRSMHEKMCLLAFEADMEKAFAV 206
Query: 795 KLSQDVECCVCLERVLSKPTPAERKFGLLTECDHAFCIGCIRNWRSSSPSTGMDVNSTLR 974
+LSQ+ C +C+E V+ K P++R+FG+L+ C H FC+ CIR WR + + N ++
Sbjct: 207 QLSQEKVCSICMEVVVQKMNPSDRRFGILSSCCHVFCLACIRKWRCTRNFS----NKIIK 262
Query: 975 ACPICRKLSYFVVPSVIWFSDPEEKKEIMDNYRDKLRSIDCKHFNFGDGNCPFGTSCFYK 1154
+CP CR S FV+PSV W + E+K +++ ++ + CK+F+ G G+CPFG C Y
Sbjct: 263 SCPECRVASEFVIPSVYWEENQEDKVHLIELFKSGVGKKPCKYFDQGRGSCPFGGKCLYL 322
Query: 1155 HAFHDG-RLEEVVLRHLDAEDGQTVIAKEIRLSDFL 1259
HA DG R E R +G +RL DF+
Sbjct: 323 HALPDGSRAEPEQPRKQLGSEGNIRFMNSVRLWDFI 358
Database: UniProt/SwissProt
Posted date: Sat Aug 07 14:36:18 2010
Number of letters in database: 182,829,261
Number of sequences in database: 518,415
Lambda K H
0.267 0.041 0.140
Gapped
Lambda K H
0.267 0.041 0.140
Matrix: blosum62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 111,298,541,542
Number of Sequences: 518415
Number of Extensions: 111298541542
Number of Successful Extensions: 710082078
Number of sequences better than 0.0: 0
|
