BLASTX 7.6.2
Query= UN27819 /QuerySize=1191
(1190 letters)
Database: UniProt/SwissProt;
518,415 sequences; 182,829,261 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q6MEE7|TRUA1_PARUW tRNA pseudouridine synthase A 1 OS=Protoch... 195 5e-049
sp|P70973|TRUA_BACSU tRNA pseudouridine synthase A OS=Bacillus s... 184 1e-045
sp|A5VLH4|TRUA_LACRD tRNA pseudouridine synthase A OS=Lactobacil... 183 3e-045
sp|B2G8U7|TRUA_LACRJ tRNA pseudouridine synthase A OS=Lactobacil... 183 3e-045
sp|A7Z0S0|TRUA_BACA2 tRNA pseudouridine synthase A OS=Bacillus a... 180 2e-044
sp|A3DJK8|TRUA_CLOTH tRNA pseudouridine synthase A OS=Clostridiu... 173 3e-042
sp|Q8XLQ0|TRUA1_CLOPE tRNA pseudouridine synthase A 1 OS=Clostri... 172 5e-042
sp|A8F9B7|TRUA_BACP2 tRNA pseudouridine synthase A OS=Bacillus p... 168 1e-040
sp|Q65P74|TRUA_BACLD tRNA pseudouridine synthase A OS=Bacillus l... 166 5e-040
sp|Q63GF1|TRUA2_BACCZ tRNA pseudouridine synthase A 2 OS=Bacillu... 163 3e-039
sp|Q73E17|TRUA2_BACC1 tRNA pseudouridine synthase A 2 OS=Bacillu... 162 5e-039
sp|Q5FM60|TRUA_LACAC tRNA pseudouridine synthase A OS=Lactobacil... 160 3e-038
sp|Q9CI80|TRUA_LACLA tRNA pseudouridine synthase A OS=Lactococcu... 159 3e-038
sp|Q6I3T8|TRUA2_BACAN tRNA pseudouridine synthase A 2 OS=Bacillu... 159 4e-038
sp|A8YTB0|TRUA_LACH4 tRNA pseudouridine synthase A OS=Lactobacil... 159 4e-038
sp|Q6HNW5|TRUA2_BACHK tRNA pseudouridine synthase A 2 OS=Bacillu... 159 6e-038
sp|Q74L59|TRUA_LACJO tRNA pseudouridine synthase A OS=Lactobacil... 158 7e-038
sp|B9K8Q0|TRUA_THENN tRNA pseudouridine synthase A OS=Thermotoga... 153 2e-036
sp|B1LB83|TRUA_THESQ tRNA pseudouridine synthase A OS=Thermotoga... 151 9e-036
sp|A5IM09|TRUA_THEP1 tRNA pseudouridine synthase A OS=Thermotoga... 148 1e-034
>sp|Q6MEE7|TRUA1_PARUW tRNA pseudouridine synthase A 1 OS=Protochlamydia
amoebophila (strain UWE25) GN=truA1 PE=3 SV=1
Length = 256
Score = 195 bits (495), Expect = 5e-049
Identities = 104/255 (40%), Positives = 162/255 (63%), Gaps = 7/255 (2%)
Frame = +2
Query: 146 WRLVIAYDGTKFAGWQYQESPPTIQSMLEKALTQITKLQRKQLHLVGAGRTDAGVHAWGQ 325
++L IAYDGT ++GWQ Q + +IQ +++AL + L+++++ LVG+GRTDAGVHA GQ
Sbjct: 4 YKLTIAYDGTNYSGWQIQPNASSIQQKIQEALCIL--LKKEKVVLVGSGRTDAGVHAKGQ 61
Query: 326 VAHFVTPFNYTSLDSIHAALNGLLPQDIRVREIGAAVHEFHARFSCRSKVYRYQIYSDTF 505
VAHF +Y L +H +LNGLLP+DIR++ + FH+++S K Y Y ++ +
Sbjct: 62 VAHFHFQ-DYIDLSRLHVSLNGLLPRDIRIKAVEPVSPRFHSQYSAIRKEYHYYLHLNKV 120
Query: 506 MDPFQRHLAYHTAYKLNASKMREAAQHFVGKHDFSAFAN-ATREDGAPDPLKTISRFDVI 682
MDPFQR ++H K++ + +++AA F G HDF++FAN A R A +P++T+ R D+
Sbjct: 121 MDPFQRLYSWHFQRKIDVNILKKAAILFTGTHDFTSFANEAHRGTAAKNPVRTLYRLDIK 180
Query: 683 EMGSLLQLEVEGSGFMYRQVRNMVALLVQVGKEALDSDIVPMILETKDRRELAKYTLPAP 862
L+LE EG GF+Y+ VRN+V L+ V + + I K+RR+ +L AP
Sbjct: 181 PNEGGLRLEFEGDGFLYKMVRNIVGTLMDVASHKRAIEEINQIFAAKNRRQA---SLAAP 237
Query: 863 PHGLCLVSVKYKEDH 907
P GL L+ V Y+ ++
Sbjct: 238 PEGLFLIQVFYENEN 252
>sp|P70973|TRUA_BACSU tRNA pseudouridine synthase A OS=Bacillus subtilis GN=truA
PE=3 SV=2
Length = 247
Score = 184 bits (467), Expect = 1e-045
Identities = 106/247 (42%), Positives = 143/247 (57%), Gaps = 7/247 (2%)
Frame = +2
Query: 149 RLVIAYDGTKFAGWQYQESPPTIQSMLEKALTQITKLQRKQLHLVGAGRTDAGVHAWGQV 328
+ I+YDG F G+Q Q T+Q LEKAL + K + ++ +V +GRTD+GVHA GQV
Sbjct: 4 KCTISYDGHLFNGYQVQPGKRTVQDELEKALAVLHK-SKDRIPVVSSGRTDSGVHAAGQV 62
Query: 329 AHFVTPFNYTSLDSIHAALNGLLPQDIRVREIGAAVHEFHARFSCRSKVYRYQIYSDTFM 508
HF TP + + + ALN LLP DI V++ A FHARFS K YRY +Y++
Sbjct: 63 IHFDTPLSIPA-ERWPYALNALLPDDIAVKQAEIADDGFHARFSAVKKEYRYFVYTEKHP 121
Query: 509 DPFQRHLAYHTAYKLNASKMREAAQHFVGKHDFSAFANATREDGAPDPLKTISRFDVIEM 688
D F+RH AYH +Y+LN MREAA+H +G HDF++F A E D ++TI D E
Sbjct: 122 DVFKRHYAYHFSYRLNVQDMREAAKHLIGTHDFTSFCAAKTE--VQDKVRTIYELDWTET 179
Query: 689 GSLLQLEVEGSGFMYRQVRNMVALLVQVGKEALDSDIVPMILETKDRRELAKYTLPAPPH 868
LQ+ + GSGF+Y VR + L+ G + D V +LE KDR + AP H
Sbjct: 180 ADGLQMRITGSGFLYNMVRIIAGTLLDAGIGKISPDEVKSMLEAKDREAAGR---TAPGH 236
Query: 869 GLCLVSV 889
GL L +V
Sbjct: 237 GLYLWNV 243
>sp|A5VLH4|TRUA_LACRD tRNA pseudouridine synthase A OS=Lactobacillus reuteri
(strain DSM 20016) GN=truA PE=3 SV=1
Length = 256
Score = 183 bits (463), Expect = 3e-045
Identities = 101/254 (39%), Positives = 155/254 (61%), Gaps = 8/254 (3%)
Frame = +2
Query: 140 YKWRLVIAYDGTKFAGWQYQESPPTIQSMLEKALTQITKLQRKQLHLVGAGRTDAGVHAW 319
Y++++ AYDGT F+G+Q Q + T++ L+ A+ +I K + ++G+GRTDAGVHA
Sbjct: 2 YRYKITFAYDGTNFSGFQIQPNKRTVEQTLKNAVNKIAKHPTPAIPVIGSGRTDAGVHAL 61
Query: 320 GQVAHFVTPFNYTSLDSIHAALNGLLPQDIRVREIGAAVHEFHARFSCRSKVYRYQIYSD 499
QVAHF P+ + S +S+ ALN +LP DI +++ ++FHAR+S K YRY++
Sbjct: 62 NQVAHFDIPY-HLSNESMRKALNSILPLDILIKKAELVDNDFHARYSAHRKTYRYRVDQG 120
Query: 500 TFMDPFQRHLAYHTAYKLNASKMREAAQHFVGKHDFSAFANATREDGAPDPLKTISRFDV 679
F++PF+R+ H Y LN KMR+AA VG HDF++F + + A ++TI +
Sbjct: 121 EFVNPFKRNYTSHFKYPLNLEKMRKAADDLVGTHDFTSFVASGSQ--AKSNVRTIENITI 178
Query: 680 --IEMGSLLQLEVEGSGFMYRQVRNMVALLVQVGKEALDSDIVPMILETKDRRELAKYTL 853
E+ + + + G+GF+Y QVR MVA L+++G D V +L+ KD R LA+ T
Sbjct: 179 KRDEVRNEVVFDFTGNGFLYNQVRIMVAFLLEIGSNQRPVDDVSRVLKAKD-RTLARMT- 236
Query: 854 PAPPHGLCLVSVKY 895
AP GL LV+V Y
Sbjct: 237 -APASGLYLVNVDY 249
>sp|B2G8U7|TRUA_LACRJ tRNA pseudouridine synthase A OS=Lactobacillus reuteri
(strain JCM 1112) GN=truA PE=3 SV=1
Length = 256
Score = 183 bits (463), Expect = 3e-045
Identities = 101/254 (39%), Positives = 155/254 (61%), Gaps = 8/254 (3%)
Frame = +2
Query: 140 YKWRLVIAYDGTKFAGWQYQESPPTIQSMLEKALTQITKLQRKQLHLVGAGRTDAGVHAW 319
Y++++ AYDGT F+G+Q Q + T++ L+ A+ +I K + ++G+GRTDAGVHA
Sbjct: 2 YRYKITFAYDGTNFSGFQIQPNKRTVEQTLKNAVNKIAKHPTPAIPVIGSGRTDAGVHAL 61
Query: 320 GQVAHFVTPFNYTSLDSIHAALNGLLPQDIRVREIGAAVHEFHARFSCRSKVYRYQIYSD 499
QVAHF P+ + S +S+ ALN +LP DI +++ ++FHAR+S K YRY++
Sbjct: 62 NQVAHFDIPY-HLSNESMRKALNSILPLDILIKKAELVDNDFHARYSAHRKTYRYRVDQG 120
Query: 500 TFMDPFQRHLAYHTAYKLNASKMREAAQHFVGKHDFSAFANATREDGAPDPLKTISRFDV 679
F++PF+R+ H Y LN KMR+AA VG HDF++F + + A ++TI +
Sbjct: 121 EFVNPFKRNYTSHFKYPLNLEKMRKAADDLVGTHDFTSFVASGSQ--AKSNVRTIENITI 178
Query: 680 --IEMGSLLQLEVEGSGFMYRQVRNMVALLVQVGKEALDSDIVPMILETKDRRELAKYTL 853
E+ + + + G+GF+Y QVR MVA L+++G D V +L+ KD R LA+ T
Sbjct: 179 KRDEVRNEVVFDFTGNGFLYNQVRIMVAFLLEIGSNQRPVDDVSRVLKAKD-RTLARMT- 236
Query: 854 PAPPHGLCLVSVKY 895
AP GL LV+V Y
Sbjct: 237 -APASGLYLVNVDY 249
>sp|A7Z0S0|TRUA_BACA2 tRNA pseudouridine synthase A OS=Bacillus
amyloliquefaciens (strain FZB42) GN=truA PE=3 SV=1
Length = 247
Score = 180 bits (456), Expect = 2e-044
Identities = 108/247 (43%), Positives = 138/247 (55%), Gaps = 7/247 (2%)
Frame = +2
Query: 149 RLVIAYDGTKFAGWQYQESPPTIQSMLEKALTQITKLQRKQLHLVGAGRTDAGVHAWGQV 328
+ IAYDG F G+Q Q T+QS LEKAL I K + + + +GRTD+ VHA GQV
Sbjct: 4 KCTIAYDGHLFNGYQVQPGKRTVQSELEKALAVIHKTDGR-VPVYSSGRTDSDVHAAGQV 62
Query: 329 AHFVTPFNYTSLDSIHAALNGLLPQDIRVREIGAAVHEFHARFSCRSKVYRYQIYSDTFM 508
HF TP + + ALN LLP DI V+ A FHARFS K YRY +Y++
Sbjct: 63 IHFDTPLSIPG-EKWPFALNALLPDDIAVKTAEIADDGFHARFSAVQKEYRYFVYTEKHP 121
Query: 509 DPFQRHLAYHTAYKLNASKMREAAQHFVGKHDFSAFANATREDGAPDPLKTISRFDVIEM 688
D F+RH AYH AY LN KMREA++H VG HDF++F A + D ++TI D E
Sbjct: 122 DVFKRHYAYHFAYPLNVQKMREASRHLVGTHDFTSFCAA--DTAVQDKVRTIYELDWTET 179
Query: 689 GSLLQLEVEGSGFMYRQVRNMVALLVQVGKEALDSDIVPMILETKDRRELAKYTLPAPPH 868
LQ+ + G+GF+Y VR + L+ G D V +LE KDR + AP H
Sbjct: 180 VDGLQMRITGNGFLYNMVRIIAGTLLDTGAGKFSPDDVKAMLEAKDREAAGR---TAPGH 236
Query: 869 GLCLVSV 889
GL L SV
Sbjct: 237 GLYLWSV 243
>sp|A3DJK8|TRUA_CLOTH tRNA pseudouridine synthase A OS=Clostridium thermocellum
(strain ATCC 27405 / DSM 1237) GN=truA PE=3 SV=1
Length = 244
Score = 173 bits (437), Expect = 3e-042
Identities = 93/245 (37%), Positives = 144/245 (58%), Gaps = 9/245 (3%)
Frame = +2
Query: 149 RLVIAYDGTKFAGWQYQESPPTIQSMLEKALTQITKLQRKQLHLVGAGRTDAGVHAWGQV 328
+L+I YDGT + GWQ Q++ T+Q +E+A+ +T +++ L+GA RTD GVHA GQV
Sbjct: 5 KLIIEYDGTNYHGWQKQKNAKTVQDTIERAIKGLT---GEKVDLIGASRTDFGVHALGQV 61
Query: 329 AHFVTPFNYTSLDSIHAALNGLLPQDIRVREIGAAVHEFHARFSCRSKVYRYQIYSDTFM 508
A+F+T D ALN +LP DI ++E +FHAR+ + K YRY IY+ F
Sbjct: 62 ANFITNSGIPG-DRFSYALNRMLPDDIVIKESQEVDMDFHARYKAKGKRYRYLIYNSQFP 120
Query: 509 DPFQRHLAYHTAYKLNASKMREAAQHFVGKHDFSAFANATREDGAPDPLKTISRFDVIEM 688
RH YH ++KL+ M+ AA +F+G HDFSAF ++ A ++TI+ +
Sbjct: 121 SALLRHRTYHVSHKLDFESMQRAASYFLGTHDFSAFRSS--GSSAKTSVRTITDVSLERE 178
Query: 689 GSLLQLEVEGSGFMYRQVRNMVALLVQVGKEALDSDIVPMILETKDRRELAKYTLPAPPH 868
+++ E+ G GF+Y VR +V L++VG + +D +P I+E++ R+ + AP
Sbjct: 179 DKIVKFEIAGDGFLYNMVRIIVGTLMEVGIGKIRADEIPQIIESRKRKRAGR---TAPAE 235
Query: 869 GLCLV 883
GL LV
Sbjct: 236 GLYLV 240
>sp|Q8XLQ0|TRUA1_CLOPE tRNA pseudouridine synthase A 1 OS=Clostridium
perfringens GN=truA1 PE=3 SV=1
Length = 248
Score = 172 bits (435), Expect = 5e-042
Identities = 98/249 (39%), Positives = 147/249 (59%), Gaps = 13/249 (5%)
Frame = +2
Query: 149 RLVIAYDGTKFAGWQYQ----ESPPTIQSMLEKALTQITKLQRKQLHLVGAGRTDAGVHA 316
++ + YDG+K+ GWQ Q + T+Q LEK LT++T +++ L+G GRTD+GVHA
Sbjct: 5 KITLDYDGSKYKGWQKQNQKGSNVSTVQDKLEKVLTKMTS---EEIQLIGCGRTDSGVHA 61
Query: 317 WGQVAHFVTPFNYTSLDSIHAALNGLLPQDIRVREIGAAVHEFHARFSCRSKVYRYQIYS 496
VA+F T + +L+ I +N LP+DIRV EI A FHARF+ +SK Y Y I +
Sbjct: 62 KNYVANFKTN-SLMTLEQIIEYINEYLPEDIRVTEIREASERFHARFNVKSKTYEYTIDN 120
Query: 497 DTFMDPFQRHLAYHTAYKLNASKMREAAQHFVGKHDFSAFANATREDGAPDPLKTISRFD 676
+ F D F R A+H KL+ M E A++ +G HDF +F + ++ L+TI+ +
Sbjct: 121 NKFKDVFLRKYAWHVEEKLDLEAMEEGAKYLLGTHDFKSFTSLKSKN--KSTLRTINSIE 178
Query: 677 VIEMGSLLQLEVEGSGFMYRQVRNMVALLVQVGKEALDSDIVPMILETKDRRELAKYTLP 856
E ++L +++ G+GF+ VR MV LV VG ++ + ILE K+R AK +
Sbjct: 179 FHENNNILSIKINGNGFLLNMVRIMVGTLVDVGLGKIEPKYINDILEAKER---AKASEK 235
Query: 857 APPHGLCLV 883
AP HGLCL+
Sbjct: 236 APAHGLCLL 244
>sp|A8F9B7|TRUA_BACP2 tRNA pseudouridine synthase A OS=Bacillus pumilus (strain
SAFR-032) GN=truA PE=3 SV=1
Length = 247
Score = 168 bits (423), Expect = 1e-040
Identities = 97/247 (39%), Positives = 141/247 (57%), Gaps = 7/247 (2%)
Frame = +2
Query: 149 RLVIAYDGTKFAGWQYQESPPTIQSMLEKALTQITKLQRKQLHLVGAGRTDAGVHAWGQV 328
+ ++YDGT F G+Q Q T+Q+ +E AL ++ K Q + + +V +GRTD+GVHA GQV
Sbjct: 4 KCTVSYDGTHFKGYQVQPGQRTVQTEIESALAKMHK-QDELVPIVASGRTDSGVHAKGQV 62
Query: 329 AHFVTPFNYTSLDSIHAALNGLLPQDIRVREIGAAVHEFHARFSCRSKVYRYQIYSDTFM 508
HF TP + ++ ALN LLP DIRV + FHARFS SK YRY++ ++T
Sbjct: 63 IHFDTPLS-IPMERWPFALNSLLPDDIRVLKAEEVDESFHARFSVVSKEYRYKVSTETHQ 121
Query: 509 DPFQRHLAYHTAYKLNASKMREAAQHFVGKHDFSAFANATREDGAPDPLKTISRFDVIEM 688
+ F R A H Y+L+A KMREAA + +G HDF++F A E D ++ I + +
Sbjct: 122 NVFTRQYACHFPYRLDADKMREAAGYLIGTHDFTSFCAANTE--VQDKVREIYTLEWKNV 179
Query: 689 GSLLQLEVEGSGFMYRQVRNMVALLVQVGKEALDSDIVPMILETKDRRELAKYTLPAPPH 868
L++ V G+GF+Y VR + L++VG D + +L ++R K AP H
Sbjct: 180 SDGLEMRVRGNGFLYNMVRIIAGTLLEVGSGKFHPDEIKAMLAARNREAAGK---TAPSH 236
Query: 869 GLCLVSV 889
GL L V
Sbjct: 237 GLYLWEV 243
>sp|Q65P74|TRUA_BACLD tRNA pseudouridine synthase A OS=Bacillus licheniformis
(strain DSM 13 / ATCC 14580) GN=truA PE=3 SV=1
Length = 247
Score = 166 bits (418), Expect = 5e-040
Identities = 101/245 (41%), Positives = 139/245 (56%), Gaps = 9/245 (3%)
Frame = +2
Query: 149 RLVIAYDGTKFAGWQYQESPPTIQSMLEKALTQITKLQRKQLHLVGAGRTDAGVHAWGQV 328
+ I+YDG F G+Q Q TIQ LEKAL + K ++++ +V +GRTD+GVHA GQ
Sbjct: 4 KCTISYDGHLFYGYQVQPGQRTIQDELEKALQTLHK-AKERIPVVSSGRTDSGVHAVGQT 62
Query: 329 AHFVTPFNYTSLDSIHAALNGLLPQDIRVREIGAAVHEFHARFSCRSKVYRYQIYSDTFM 508
HF +P + + ALN LLP DI VR+ A +FHARFS + K YRY IY
Sbjct: 63 IHFDSPLSIPEAKWPY-ALNALLPDDISVRKAEAVNDQFHARFSAKRKEYRYMIYRGRHP 121
Query: 509 DPFQRHLAYHTAYKLNASKMREAAQHFVGKHDFSAFANATREDGAPDPLKTISRFDVIEM 688
D F+R+ AYH Y L+ K++EA+++ VG HDF++F E D ++T+ + +
Sbjct: 122 DVFKRYYAYHVPYDLDMEKVKEASRYLVGTHDFTSFCATKTE--VKDKVRTVHELEWSDT 179
Query: 689 GSLLQLEVEGSGFMYRQVRNMVALLVQVGKEALD-SDIVPMILETKDRRELAKYTLPAPP 865
G LQ+ + GSGF+Y VR + L+ VG DI MIL R+ A T AP
Sbjct: 180 GDGLQMRIVGSGFLYNMVRIIAGTLLDVGTGKFSPGDIEKMIL--AKNRDAAGRT--APA 235
Query: 866 HGLCL 880
HGL L
Sbjct: 236 HGLYL 240
>sp|Q63GF1|TRUA2_BACCZ tRNA pseudouridine synthase A 2 OS=Bacillus cereus
(strain ZK / E33L) GN=truA2 PE=3 SV=1
Length = 245
Score = 163 bits (411), Expect = 3e-039
Identities = 84/232 (36%), Positives = 134/232 (57%), Gaps = 7/232 (3%)
Frame = +2
Query: 146 WRLVIAYDGTKFAGWQ-YQESPPTIQSMLEKALTQITKLQRKQLHLVGAGRTDAGVHAWG 322
++L I YDG +F GWQ + TIQ +E I+++ K++ ++G RTDAGVHA
Sbjct: 4 YKLTIQYDGARFKGWQRLGNNDNTIQGKIESV---ISEMIGKEIEIIGCSRTDAGVHALN 60
Query: 323 QVAHFVTPFNYTSLDSIHAALNGLLPQDIRVREIGAAVHEFHARFSCRSKVYRYQIYSDT 502
QVA+F + + LN LP DI + + FHAR++ ++K Y Y+I+++
Sbjct: 61 QVANFQSDEKLVE-HKVKKYLNQYLPNDISITNVEEVHDRFHARYNSKAKTYLYKIWNEE 119
Query: 503 FMDPFQRHLAYHTAYKLNASKMREAAQHFVGKHDFSAFANATREDGAPDPLKTISRFDVI 682
+PF R + H KLN M+EAA+H VG HDF+AF+NA + ++ + +V+
Sbjct: 120 HTNPFMRKYSMHVNKKLNVKSMKEAAKHLVGSHDFTAFSNA--KSKKKSMVREVYSLEVM 177
Query: 683 EMGSLLQLEVEGSGFMYRQVRNMVALLVQVGKEALDSDIVPMILETKDRREL 838
E +Q+ V G+GF++ VR +V L++VG LD++ +P ILE K R ++
Sbjct: 178 EEAGFVQIRVSGNGFLHNMVRKIVGALIEVGLGQLDAEAIPQILEAKQRNQI 229
>sp|Q73E17|TRUA2_BACC1 tRNA pseudouridine synthase A 2 OS=Bacillus cereus
(strain ATCC 10987) GN=truA2 PE=3 SV=1
Length = 245
Score = 162 bits (409), Expect = 5e-039
Identities = 84/232 (36%), Positives = 133/232 (57%), Gaps = 7/232 (3%)
Frame = +2
Query: 146 WRLVIAYDGTKFAGWQ-YQESPPTIQSMLEKALTQITKLQRKQLHLVGAGRTDAGVHAWG 322
++L I YDG +F GWQ + TIQ +E I+++ K+ ++G RTDAGVHA
Sbjct: 4 YKLTIQYDGARFKGWQRLGNNDNTIQGKIESV---ISEMVGKETEIIGCSRTDAGVHALN 60
Query: 323 QVAHFVTPFNYTSLDSIHAALNGLLPQDIRVREIGAAVHEFHARFSCRSKVYRYQIYSDT 502
QVA+F + + LN LP DI + + FHAR++ ++K Y Y+I+++
Sbjct: 61 QVANFQSDEKLVE-HKVKKYLNQYLPNDISITNVEEVHDRFHARYNSKAKTYLYKIWNEE 119
Query: 503 FMDPFQRHLAYHTAYKLNASKMREAAQHFVGKHDFSAFANATREDGAPDPLKTISRFDVI 682
+PF R + H KLN M+EAA+H VG HDF+AF+NA + ++ + +V+
Sbjct: 120 HTNPFMRKYSMHVNKKLNVKSMKEAAKHLVGSHDFTAFSNA--KSKKKSMVREVYTLEVM 177
Query: 683 EMGSLLQLEVEGSGFMYRQVRNMVALLVQVGKEALDSDIVPMILETKDRREL 838
E +Q+ V G+GF++ VR +V L++VG LD++ +P ILE K R ++
Sbjct: 178 EEAGFVQIRVSGNGFLHNMVRKIVGALIEVGLGQLDAEAIPQILEAKQRNQI 229
>sp|Q5FM60|TRUA_LACAC tRNA pseudouridine synthase A OS=Lactobacillus acidophilus
GN=truA PE=3 SV=1
Length = 262
Score = 160 bits (403), Expect = 3e-038
Identities = 96/255 (37%), Positives = 147/255 (57%), Gaps = 9/255 (3%)
Frame = +2
Query: 143 KWRLVIAYDGTKFAGWQYQESPPTIQSMLEKALTQITKLQRKQLHLVGAGRTDAGVHAWG 322
++++ +AYDG F G+Q Q T+Q +E AL ++TK K++ + G+GRTDAGVHA G
Sbjct: 4 RYKMTMAYDGHLFHGFQLQPDQRTVQGTVEDALKKMTK--GKRIIVQGSGRTDAGVHAIG 61
Query: 323 QVAHFVTPFNYTSLDSIHAALNGLLPQDIRVREIGAAVHEFHARFSCRSKVYRYQIYSDT 502
QV HF P + + ALN ++P DI + +FHAR+S + K YRY++ D
Sbjct: 62 QVIHFDYPGKEIPANRMILALNSMMPTDIVFTDCQIVDEDFHARYSIKGKWYRYRLSLDY 121
Query: 503 FMDPFQRHLAYHTAYKLNASKMREAAQHFVGKHDFSAFANATREDGAPDPLKTISRFDVI 682
F++PF+R H Y+L+ KMR AAQ +GKHDF++FA + + D ++TI ++
Sbjct: 122 FVNPFKRFYTGHFPYQLDLEKMRIAAQDLLGKHDFTSFAASGGQ--IKDKVRTIYYINIT 179
Query: 683 --EMGSLLQLEVEGSGFMYRQVRNMVALLVQVGKEALDSDIVPMILETKDRRELAKYTLP 856
E + + + GSGF+Y VR MVA L+++G E + ++ KDR+E+ +
Sbjct: 180 KDEKENEIVFDFIGSGFLYNMVRIMVAALLEIGNERRPLHDLRRVIAAKDRQEVRQ---T 236
Query: 857 APPHGLCLVSVKYKE 901
A GL L V Y E
Sbjct: 237 AQGSGLYLYHVFYDE 251
>sp|Q9CI80|TRUA_LACLA tRNA pseudouridine synthase A OS=Lactococcus lactis subsp.
lactis GN=truA PE=3 SV=1
Length = 253
Score = 159 bits (402), Expect = 3e-038
Identities = 91/255 (35%), Positives = 142/255 (55%), Gaps = 8/255 (3%)
Frame = +2
Query: 143 KWRLVIAYDGTKFAGWQYQESPPTIQSMLEKALTQITKLQRKQLHLVGAGRTDAGVHAWG 322
+++ IAYDGT FAG+Q Q + T+Q +EK LT++ + + L G+GRTD+GVHA+G
Sbjct: 3 RYKATIAYDGTDFAGFQSQTNQRTVQKEIEKILTKLNSFE--PVILQGSGRTDSGVHAFG 60
Query: 323 QVAHFVTPFNYTSLDSIHAALNGLLPQDIRVREIGAAVHEFHARFSCRSKVYRYQIYSDT 502
QV HF L+ + L+ P DI V+++ ++HAR+ K Y Y + +
Sbjct: 61 QVIHFDLKGKVRDLERLRFGLDTQTPADIAVKKVELVPDDWHARYQKHEKTYEYYLENSI 120
Query: 503 FMDPFQRHLAYHTAYKLNASKMREAAQHFVGKHDFSAFANATREDGAPDPLKTISRFDVI 682
PFQRH + Y LN +M+EA VG+HDF+ F D ++TI + ++I
Sbjct: 121 TRSPFQRHSKAYFRYPLNFERMQEAMSKLVGEHDFTGF--TASGSSVDDKVRTIYQAEII 178
Query: 683 EMG-SLLQLEVEGSGFMYRQVRNMVALLVQVGKEALDSDIVPMILETKDRRELAKYTLPA 859
+ + G+GF+Y+QVRNMV ++++G + + + IL +K+ R+ A T A
Sbjct: 179 RLDEENFKFIFRGNGFLYKQVRNMVGTVIKIGNDRMPVSQIDKILTSKN-RDFAGPT--A 235
Query: 860 PPHGLCLVSVKYKED 904
P GL L VKY E+
Sbjct: 236 APEGLYLKEVKYAEN 250
>sp|Q6I3T8|TRUA2_BACAN tRNA pseudouridine synthase A 2 OS=Bacillus anthracis
GN=truA2 PE=3 SV=1
Length = 245
Score = 159 bits (401), Expect = 4e-038
Identities = 83/232 (35%), Positives = 132/232 (56%), Gaps = 7/232 (3%)
Frame = +2
Query: 146 WRLVIAYDGTKFAGWQ-YQESPPTIQSMLEKALTQITKLQRKQLHLVGAGRTDAGVHAWG 322
++L I YDG +F GWQ + TIQ +E I+++ K+ ++G RTDAGVHA
Sbjct: 4 YKLTIQYDGARFKGWQRLGNNDNTIQGKIESV---ISEMVGKETEIIGCSRTDAGVHALN 60
Query: 323 QVAHFVTPFNYTSLDSIHAALNGLLPQDIRVREIGAAVHEFHARFSCRSKVYRYQIYSDT 502
QVA+F + + LN LP DI + + FHAR++ ++K Y Y+I+++
Sbjct: 61 QVANFQSDEKLVE-HKVKKYLNQYLPNDISITNVEEVHDRFHARYNSKAKTYLYKIWNEE 119
Query: 503 FMDPFQRHLAYHTAYKLNASKMREAAQHFVGKHDFSAFANATREDGAPDPLKTISRFDVI 682
+PF R + H KLN M+EAA+H VG HDF+AF+NA + ++ + +V+
Sbjct: 120 HTNPFMRKYSMHVNKKLNVKSMKEAAKHLVGSHDFTAFSNA--KSKKKSMVREVYSLEVM 177
Query: 683 EMGSLLQLEVEGSGFMYRQVRNMVALLVQVGKEALDSDIVPMILETKDRREL 838
E +Q+ V G+GF++ VR +V L++VG L ++ +P ILE K R ++
Sbjct: 178 EEAGFVQIRVSGNGFLHNMVRKIVGALIEVGLGQLAAEAIPQILEAKQRNQI 229
>sp|A8YTB0|TRUA_LACH4 tRNA pseudouridine synthase A OS=Lactobacillus helveticus
(strain DPC 4571) GN=truA PE=3 SV=1
Length = 263
Score = 159 bits (401), Expect = 4e-038
Identities = 95/257 (36%), Positives = 146/257 (56%), Gaps = 9/257 (3%)
Frame = +2
Query: 143 KWRLVIAYDGTKFAGWQYQESPPTIQSMLEKALTQITKLQRKQLHLVGAGRTDAGVHAWG 322
++++ +AYDG F G+Q Q T+Q +E AL ++TK K++ + G+GRTDAGVHA G
Sbjct: 4 RYKMTMAYDGHLFHGFQLQPDQRTVQGTVEDALKKMTK--GKRIIVQGSGRTDAGVHAIG 61
Query: 323 QVAHFVTPFNYTSLDSIHAALNGLLPQDIRVREIGAAVHEFHARFSCRSKVYRYQIYSDT 502
QV HF P + + ALN ++P DI FHAR+S + K YRY++ D
Sbjct: 62 QVIHFDYPGKTIPANRMILALNSMMPTDIIFNNCEIVNENFHARYSIKGKWYRYRVSLDH 121
Query: 503 FMDPFQRHLAYHTAYKLNASKMREAAQHFVGKHDFSAFANATREDGAPDPLKTISRFDVI 682
F++PF+R H +Y L+ KM+EAA+ +GKHDF++FA + + D ++TI ++
Sbjct: 122 FVNPFKRFYTGHFSYALDVGKMQEAAKDLLGKHDFTSFAASGGQ--IEDKVRTIYYVNIA 179
Query: 683 --EMGSLLQLEVEGSGFMYRQVRNMVALLVQVGKEALDSDIVPMILETKDRRELAKYTLP 856
E + + + GSGF+Y VR MVA L+++G + ++ KDR+E+ +
Sbjct: 180 KDEKENEIVFDFIGSGFLYNMVRIMVAALLEIGNGRRPVHDLKRVIAAKDRQEVRQ---T 236
Query: 857 APPHGLCLVSVKYKEDH 907
A GL L V Y E H
Sbjct: 237 AQASGLYLYHVFYDEYH 253
>sp|Q6HNW5|TRUA2_BACHK tRNA pseudouridine synthase A 2 OS=Bacillus thuringiensis
subsp. konkukian GN=truA2 PE=3 SV=1
Length = 245
Score = 159 bits (400), Expect = 6e-038
Identities = 83/232 (35%), Positives = 132/232 (56%), Gaps = 7/232 (3%)
Frame = +2
Query: 146 WRLVIAYDGTKFAGWQ-YQESPPTIQSMLEKALTQITKLQRKQLHLVGAGRTDAGVHAWG 322
++L I YDG +F GWQ + TIQ +E I+++ K+ ++G RTDAGVHA
Sbjct: 4 YKLTIQYDGARFKGWQRLGNNDNTIQGKIESV---ISEMVGKETEIIGCSRTDAGVHALN 60
Query: 323 QVAHFVTPFNYTSLDSIHAALNGLLPQDIRVREIGAAVHEFHARFSCRSKVYRYQIYSDT 502
QVA+F + + LN LP DI + + + FHAR++ + K Y Y+I+++
Sbjct: 61 QVANFQSDEKLVE-HKVKKYLNQYLPNDISITNVEEVHNRFHARYNSKVKTYLYKIWNEE 119
Query: 503 FMDPFQRHLAYHTAYKLNASKMREAAQHFVGKHDFSAFANATREDGAPDPLKTISRFDVI 682
+PF R + H KLN M+EAA+H VG HDF+AF+NA + ++ + +V+
Sbjct: 120 HTNPFMRKYSMHVNKKLNVKSMKEAAKHLVGSHDFTAFSNA--KSKKKSMVREVYSLEVM 177
Query: 683 EMGSLLQLEVEGSGFMYRQVRNMVALLVQVGKEALDSDIVPMILETKDRREL 838
E +Q+ V G+GF++ VR +V L++VG L ++ +P ILE K R ++
Sbjct: 178 EEAGFVQIRVSGNGFLHNMVRKIVGALIEVGLGQLAAEAIPQILEAKQRNQI 229
>sp|Q74L59|TRUA_LACJO tRNA pseudouridine synthase A OS=Lactobacillus johnsonii
GN=truA PE=3 SV=1
Length = 263
Score = 158 bits (399), Expect = 7e-038
Identities = 93/255 (36%), Positives = 146/255 (57%), Gaps = 9/255 (3%)
Frame = +2
Query: 143 KWRLVIAYDGTKFAGWQYQESPPTIQSMLEKALTQITKLQRKQLHLVGAGRTDAGVHAWG 322
+++L +AYDG F G+Q Q + T+Q ++E+AL ++TK +R +H G+GRTDAGVHA G
Sbjct: 4 RYKLTMAYDGHLFHGFQIQPNQRTVQGVIEEALKKMTKGKRVVVH--GSGRTDAGVHAKG 61
Query: 323 QVAHFVTPFNYTSLDSIHAALNGLLPQDIRVREIGAAVHEFHARFSCRSKVYRYQIYSDT 502
QV HF P ++ ALN L+P D E +FH ++S + K YRY +
Sbjct: 62 QVIHFDYPGKEIPAKNMMLALNALMPIDTVFFESEIVDEDFHVQYSTKGKWYRYVVDQHR 121
Query: 503 FMDPFQRHLAYHTAYKLNASKMREAAQHFVGKHDFSAFANATREDGAPDPLKTISRFDVI 682
F DPF R H Y L+ S M++AA+ +G+HDF++FA + + D ++TI ++
Sbjct: 122 FTDPFNRFYTGHYPYPLDISLMKQAAKDLIGEHDFTSFAASGGQ--IVDKVRTIYYVNIT 179
Query: 683 EMGSLLQL--EVEGSGFMYRQVRNMVALLVQVGKEALDSDIVPMILETKDRRELAKYTLP 856
Q+ + G+GF+Y VR +V L+++G + D +P +L+ KDR+E+
Sbjct: 180 PDPDKKQIIFDFIGNGFLYNMVRILVGTLLEIGNKKRPVDDIPRVLKAKDRQEV---RTT 236
Query: 857 APPHGLCLVSVKYKE 901
AP GL L V Y++
Sbjct: 237 APASGLYLQQVFYED 251
>sp|B9K8Q0|TRUA_THENN tRNA pseudouridine synthase A OS=Thermotoga neapolitana
(strain ATCC 49049 / DSM 4359 / NS-E) GN=truA PE=3 SV=1
Length = 245
Score = 153 bits (386), Expect = 2e-036
Identities = 87/241 (36%), Positives = 139/241 (57%), Gaps = 10/241 (4%)
Frame = +2
Query: 155 VIAYDGTKFAGWQYQESPPTIQSMLEKALTQITKLQRKQLHLVGAGRTDAGVHAWGQVAH 334
++ YDG+ F G+Q Q T+Q ++E AL +I K ++++ AGRTDAGVHA GQ+
Sbjct: 7 IVEYDGSNFFGYQGQPDVRTVQGVIEDALERIFK---QRIYTQAAGRTDAGVHANGQLIA 63
Query: 335 FVTPFNYTSLDSIHAALNGLLPQDIRVREIGAAVHEFHARFSCRSKVYRYQIYSDTFMDP 514
F P + + + I A+N LP D+ V+++ FH RF + ++Y Y I++ +
Sbjct: 64 FNCPNDRMTTEDIKNAMNANLPDDVYVKKVFEVPKNFHPRFDVKKRIYHYFIHTSREKNV 123
Query: 515 FQRHLAYHTAYKLNASKMREAAQHFVGKHDFSAFANATREDGAPDPLKTISRFDVIEMG- 691
F R A+ Y+L+ MR+AA++ G HDF++F + E DP++TI R ++ +G
Sbjct: 124 FLRKYAWWFPYELDLEAMRKAAKYLEGTHDFTSFKTGSDE---RDPVRTIYRIRILSLGK 180
Query: 692 SLLQLEVEGSGFMYRQVRNMVALLVQVGKEALDSDIVPMILETKDRRELAKYTLPAPPHG 871
++ + VEG F+ R VRN+VA LV+VG + + + +LE +DR A AP HG
Sbjct: 181 DMILIRVEGRSFLRRMVRNIVAALVKVGLRQWEPEKLKEVLEARDRSAAAG---TAPAHG 237
Query: 872 L 874
L
Sbjct: 238 L 238
>sp|B1LB83|TRUA_THESQ tRNA pseudouridine synthase A OS=Thermotoga sp. (strain
RQ2) GN=truA PE=3 SV=1
Length = 245
Score = 151 bits (381), Expect = 9e-036
Identities = 89/241 (36%), Positives = 137/241 (56%), Gaps = 10/241 (4%)
Frame = +2
Query: 155 VIAYDGTKFAGWQYQESPPTIQSMLEKALTQITKLQRKQLHLVGAGRTDAGVHAWGQVAH 334
VI YDG+ F G+Q Q T+Q ++E AL +I K ++++ AGRTDAGVHA GQ+
Sbjct: 7 VIEYDGSNFFGYQGQPDVRTVQGVIEDALERIFK---QRIYTQAAGRTDAGVHANGQLIA 63
Query: 335 FVTPFNYTSLDSIHAALNGLLPQDIRVREIGAAVHEFHARFSCRSKVYRYQIYSDTFMDP 514
F P + + + I A+N LP D+ V+E+ FH RF + ++Y Y I + +
Sbjct: 64 FNCPNDRMTTEDIKNAMNANLPDDVYVKEVFEVSKNFHPRFDVKKRIYHYFILTSKQKNV 123
Query: 515 FQRHLAYHTAYKLNASKMREAAQHFVGKHDFSAFANATREDGAPDPLKTISRFDVIEM-G 691
F R + Y+L+ MR+AA++ G HDF++F + E DP++TI R ++ +
Sbjct: 124 FLRKYVWWFPYELDLDAMRKAAKYLEGTHDFTSFKTGSDE---RDPVRTIYRIRILRLKN 180
Query: 692 SLLQLEVEGSGFMYRQVRNMVALLVQVGKEALDSDIVPMILETKDRRELAKYTLPAPPHG 871
L+ + VEG F+ R VRN+VA LV+VG + + + + +LE +DR A AP HG
Sbjct: 181 DLVLIRVEGRSFLRRMVRNIVAALVKVGLKQWEPEKMKEVLEARDRSAAAG---TAPAHG 237
Query: 872 L 874
L
Sbjct: 238 L 238
>sp|A5IM09|TRUA_THEP1 tRNA pseudouridine synthase A OS=Thermotoga petrophila
(strain RKU-1 / ATCC BAA-488 / DSM 13995) GN=truA PE=3 SV=1
Length = 245
Score = 148 bits (372), Expect = 1e-034
Identities = 87/241 (36%), Positives = 135/241 (56%), Gaps = 10/241 (4%)
Frame = +2
Query: 155 VIAYDGTKFAGWQYQESPPTIQSMLEKALTQITKLQRKQLHLVGAGRTDAGVHAWGQVAH 334
VI YDG+ F G+Q Q T+Q ++E AL +I K +++++ AGRTD GVHA GQ+
Sbjct: 7 VIEYDGSNFFGYQGQPDVRTVQGVIEDALERIFK---QRIYIQAAGRTDTGVHANGQLIA 63
Query: 335 FVTPFNYTSLDSIHAALNGLLPQDIRVREIGAAVHEFHARFSCRSKVYRYQIYSDTFMDP 514
F P + + + I A+N LP D+ V+E+ FH RF ++Y Y I + +
Sbjct: 64 FNCPNDRMTTEDIRNAMNANLPDDVYVKEVFEVPVNFHPRFDVTKRIYHYFILTSRQKNV 123
Query: 515 FQRHLAYHTAYKLNASKMREAAQHFVGKHDFSAFANATREDGAPDPLKTISRFDVIEM-G 691
F R + Y+L+ MR+A ++ G HDF++F + E DP++TI R ++ +
Sbjct: 124 FLRKYVWWFPYELDLDAMRKAVKYLEGTHDFTSFKTGSDE---RDPVRTIYRIRILRLKN 180
Query: 692 SLLQLEVEGSGFMYRQVRNMVALLVQVGKEALDSDIVPMILETKDRRELAKYTLPAPPHG 871
L+ + VEG F+ R VRN+VA LV+VG + + + + +LE +DR A AP HG
Sbjct: 181 DLVLIRVEGRSFLRRMVRNIVAALVKVGLKQWEPEKMKEVLEARDRSAAAG---TAPAHG 237
Query: 872 L 874
L
Sbjct: 238 L 238
Database: UniProt/SwissProt
Posted date: Sat Aug 07 14:36:18 2010
Number of letters in database: 182,829,261
Number of sequences in database: 518,415
Lambda K H
0.267 0.041 0.140
Gapped
Lambda K H
0.267 0.041 0.140
Matrix: blosum62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 116,323,427,680
Number of Sequences: 518415
Number of Extensions: 116323427680
Number of Successful Extensions: 743337835
Number of sequences better than 0.0: 0
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