BLASTX 7.6.2
Query= UN28031 /QuerySize=1640
(1639 letters)
Database: UniProt/SwissProt;
518,415 sequences; 182,829,261 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q9LZ03|TOP6A_ARATH DNA topoisomerase 6 subunit A OS=Arabidops... 448 9e-125
sp|Q8GYL7|PP361_ARATH Pentatricopeptide repeat-containing protei... 237 2e-061
sp|Q9Y5K1|SPO11_HUMAN Meiotic recombination protein SPO11 OS=Hom... 183 3e-045
sp|Q9WTK8|SPO11_MOUSE Meiotic recombination protein SPO11 OS=Mus... 183 3e-045
sp|Q9M4A2|SPO11_ARATH Meiotic recombination protein SPO11-1 OS=A... 178 1e-043
sp|A2BLE8|TOP6A_HYPBU Type 2 DNA topoisomerase 6 subunit A OS=Hy... 158 2e-037
sp|Q9M4A1|SPO12_ARATH Meiotic recombination protein SPO11-2 OS=A... 151 2e-035
sp|Q57815|TOP6A_METJA Type II DNA topoisomerase VI subunit A OS=... 139 5e-032
sp|Q9YE67|TOP6A_AERPE Type II DNA topoisomerase VI subunit A OS=... 134 3e-030
sp|O29322|TOP6A_ARCFU Type II DNA topoisomerase VI subunit A OS=... 133 4e-030
sp|O05208|TOP6A_SULSH Type II DNA topoisomerase VI subunit A OS=... 130 4e-029
sp|Q971T1|TOP6A_SULTO Type II DNA topoisomerase VI subunit A OS=... 126 5e-028
sp|Q5V4R4|TOP6A_HALMA Type II DNA topoisomerase VI subunit A OS=... 122 7e-027
sp|Q8PUB7|TOP6A_METMA Type II DNA topoisomerase VI subunit A OS=... 118 2e-025
sp|Q3IPW7|TOP6A_NATPD Type 2 DNA topoisomerase 6 subunit A OS=Na... 117 2e-025
sp|B0R4D2|TOP6A_HALS3 Type 2 DNA topoisomerase 6 subunit A OS=Ha... 117 3e-025
sp|Q9HR32|TOP6A_HALSA Type II DNA topoisomerase VI subunit A OS=... 117 3e-025
sp|Q8TQF8|TOP6A_METAC Type II DNA topoisomerase VI subunit A OS=... 117 3e-025
sp|Q468I6|TOP6A_METBF Type 2 DNA topoisomerase 6 subunit A OS=Me... 117 3e-025
sp|Q5JH82|TOP6A_PYRKO Type II DNA topoisomerase VI subunit A OS=... 112 1e-023
>sp|Q9LZ03|TOP6A_ARATH DNA topoisomerase 6 subunit A OS=Arabidopsis thaliana
GN=TOP6A PE=1 SV=1
Length = 427
Score = 448 bits (1150), Expect = 9e-125
Identities = 221/223 (99%), Positives = 222/223 (99%)
Frame = +2
Query: 2 AEKGVVVGRLIFSDNGDMIDCTKMGMGGKAIPPNIDRVGDMQSDAMFILLVEKDAAYIRL 181
AEKGVVVGRLIFSDNGDMIDCTKMGMGGKAIPPNIDRVGDMQSDAMFILLVEKDAAY+RL
Sbjct: 205 AEKGVVVGRLIFSDNGDMIDCTKMGMGGKAIPPNIDRVGDMQSDAMFILLVEKDAAYMRL 264
Query: 182 AEDRFYNRFPCIIVTAKGQPDVATRLFLRKMKMELKLPVLALVDSDPYGLKILSVYGCGS 361
AEDRFYNRFPCIIVTAKGQPDVATRLFLRKMKMELKLPVLALVDSDPYGLKILSVYGCGS
Sbjct: 265 AEDRFYNRFPCIIVTAKGQPDVATRLFLRKMKMELKLPVLALVDSDPYGLKILSVYGCGS 324
Query: 362 KNMSYYSANLTTPDIKWLGIRPSDLDKYKIPEQCRLPMTEQDIKTGKDMLEEDFVKKNPG 541
KNMSY SANLTTPDIKWLGIRPSDLDKYKIPEQCRLPMTEQDIKTGKDMLEEDFVKKNPG
Sbjct: 325 KNMSYDSANLTTPDIKWLGIRPSDLDKYKIPEQCRLPMTEQDIKTGKDMLEEDFVKKNPG 384
Query: 542 WVEELNLMVKTKQKAEIQALSSFGFQYLSEVYLPLKLQQQDWL 670
WVEELNLMVKTKQKAEIQALSSFGFQYLSEVYLPLKLQQQDWL
Sbjct: 385 WVEELNLMVKTKQKAEIQALSSFGFQYLSEVYLPLKLQQQDWL 427
>sp|Q8GYL7|PP361_ARATH Pentatricopeptide repeat-containing protein At5g02830,
chloroplastic OS=Arabidopsis thaliana GN=At5g02830 PE=2 SV=2
Length = 852
Score = 237 bits (603), Expect = 2e-061
Identities = 131/184 (71%), Positives = 151/184 (82%), Gaps = 9/184 (4%)
Frame = -2
Query: 1482 CYATAPEHSQSINKASDQEGTDSGRPVSLLIEKVARHLQERTSGHLAIDLQGLTKVEARL 1303
C E+ +S +K SDQEG ++GRPVSLLIEKVA H+QERT+G+LAIDLQGLTK+EARL
Sbjct: 678 CEGVIQENGRSQDKISDQEGDNAGRPVSLLIEKVATHMQERTAGNLAIDLQGLTKIEARL 737
Query: 1302 VVLAVLRMIKEDYTRGDVVKDDLVIILGTCEANTDSGKQEIDVKDVLVKLLKDELSLVVL 1123
VVLAVLRMIKEDY RGDVV DD++II+GT EANT SGKQEI V++ LVKLL+DELSLVVL
Sbjct: 738 VVLAVLRMIKEDYMRGDVVIDDVLIIIGTDEANTVSGKQEITVQEALVKLLRDELSLVVL 797
Query: 1122 PARQRPVLDITQDAQHVDDADQNTEHTSKNTKWIVGIFSTRRPAILERLMVTKASLHKWL 943
PA QR +I QDA VDDADQ +NTK V I STRRPAILERLMVTKASL++WL
Sbjct: 798 PAGQR---NIIQDAHCVDDADQ------ENTKSFVSISSTRRPAILERLMVTKASLYQWL 848
Query: 942 QRKK 931
QR+K
Sbjct: 849 QRRK 852
>sp|Q9Y5K1|SPO11_HUMAN Meiotic recombination protein SPO11 OS=Homo sapiens
GN=SPO11 PE=2 SV=1
Length = 396
Score = 183 bits (464), Expect = 3e-045
Identities = 91/223 (40%), Positives = 143/223 (64%), Gaps = 3/223 (1%)
Frame = +2
Query: 8 KGVVVGRLIF-SDNGDMIDCTKMGMGGKAIPPNIDRVGDMQSDAMFILLVEKDAAYIRLA 184
KG++ G L + ++G ++CT G A+P NI + ++ +DA F+L+VEKDA + RL
Sbjct: 175 KGLIAGNLRYIEEDGTKVNCT-CGATAVAVPSNIQGIRNLVTDAKFVLIVEKDATFQRLL 233
Query: 185 EDRFYNRF-PCIIVTAKGQPDVATRLFLRKMKMELKLPVLALVDSDPYGLKILSVYGCGS 361
+D F N+ PCI++T KG PD+ TRL ++K+ +PV LVD+DP+G++I+ +Y GS
Sbjct: 234 DDNFCNKLSPCIMITGKGVPDLNTRLLVKKLWDTFHVPVFTLVDADPHGIEIMCIYKYGS 293
Query: 362 KNMSYYSANLTTPDIKWLGIRPSDLDKYKIPEQCRLPMTEQDIKTGKDMLEEDFVKKNPG 541
+MS+ + +LT P I+WLG+ PSDL + +P+ +P+T++D +L +V P
Sbjct: 294 MSMSFEAHHLTVPAIRWLGLLPSDLKRLNVPKDSLIPLTKRDQMKLDSILRRPYVTCQPF 353
Query: 542 WVEELNLMVKTKQKAEIQALSSFGFQYLSEVYLPLKLQQQDWL 670
W +E+ +M +K KAEIQAL+ YLS VYLP KL+ W+
Sbjct: 354 WRKEMEIMADSKMKAEIQALTFLSSDYLSRVYLPNKLKFGGWI 396
>sp|Q9WTK8|SPO11_MOUSE Meiotic recombination protein SPO11 OS=Mus musculus
GN=Spo11 PE=2 SV=2
Length = 396
Score = 183 bits (464), Expect = 3e-045
Identities = 93/223 (41%), Positives = 140/223 (62%), Gaps = 3/223 (1%)
Frame = +2
Query: 8 KGVVVGRLIF-SDNGDMIDCTKMGMGGKAIPPNIDRVGDMQSDAMFILLVEKDAAYIRLA 184
KG++ G L + ++G + CT A+P NI + + +DA F+L+VEKDA + RL
Sbjct: 175 KGLIAGNLRYMEEDGTRVQCT-CSATATAVPTNIQGMQHLITDAKFLLIVEKDATFQRLL 233
Query: 185 EDRFYNRF-PCIIVTAKGQPDVATRLFLRKMKMELKLPVLALVDSDPYGLKILSVYGCGS 361
+D F +R PCI+VT KG PD+ TRL ++K+ +PV LVD+DPYG++I+ +Y GS
Sbjct: 234 DDNFCSRMSPCIMVTGKGVPDLNTRLLVKKLWDTFHIPVFTLVDADPYGIEIMCIYKYGS 293
Query: 362 KNMSYYSANLTTPDIKWLGIRPSDLDKYKIPEQCRLPMTEQDIKTGKDMLEEDFVKKNPG 541
+MS+ + NLT P I+WLG+ PSD+ + IP+ +P+T+ D +L+ ++ P
Sbjct: 294 MSMSFEAHNLTIPTIRWLGLLPSDIQRLNIPKDSLIPLTKHDQMKLDSILKRPYITYQPL 353
Query: 542 WVEELNLMVKTKQKAEIQALSSFGFQYLSEVYLPLKLQQQDWL 670
W +EL +M +K KAEIQAL+ YLS VYLP KL+ W+
Sbjct: 354 WKKELEMMADSKMKAEIQALTLLSSDYLSRVYLPNKLRFGGWI 396
>sp|Q9M4A2|SPO11_ARATH Meiotic recombination protein SPO11-1 OS=Arabidopsis
thaliana GN=SPO11-1 PE=1 SV=1
Length = 362
Score = 178 bits (450), Expect = 1e-043
Identities = 95/218 (43%), Positives = 134/218 (61%), Gaps = 1/218 (0%)
Frame = +2
Query: 11 GVVVGRLIFSDNGDMIDCTKMGMGGKAIPPNIDRVGDMQSDAMFILLVEKDAAYIRLAED 190
G+V+G L F + G DC +P ++ V D+ S A +IL+VEK+ + RLA D
Sbjct: 141 GLVMGWLKFREAGRKFDCLNSLNTAYPVPVLVEEVEDIVSLAEYILVVEKETVFQRLAND 200
Query: 191 RFYNRFPCIIVTAKGQPDVATRLFLRKMKMELKLPVLALVDSDPYGLKILSVYGCGSKNM 370
F CI++T +G PDV+TR FLR + +L LPV LVD DPYG +IL+ Y GS M
Sbjct: 201 MFCKTNRCIVITGRGYPDVSTRRFLRLLMEKLHLPVHCLVDCDPYGFEILATYRFGSMQM 260
Query: 371 SYYSANLTTPDIKWLGIRPSDLDKYKIPEQCRLPMTEQDIKTGKDMLEEDFVKKN-PGWV 547
+Y +L PD+KWLG PSD + Y +P+QC LP+TE+D K + ML ++K+ P W
Sbjct: 261 AYDIESLRAPDMKWLGAFPSDSEVYSVPKQCLLPLTEEDKKRTEAMLLRCYLKREMPQWR 320
Query: 548 EELNLMVKTKQKAEIQALSSFGFQYLSEVYLPLKLQQQ 661
EL M+K K EI+ALS +LSEVY+P K++++
Sbjct: 321 LELETMLKRGVKFEIEALSVHSLSFLSEVYIPSKIRRE 358
>sp|A2BLE8|TOP6A_HYPBU Type 2 DNA topoisomerase 6 subunit A OS=Hyperthermus
butylicus (strain DSM 5456 / JCM 9403) GN=top6A PE=3 SV=1
Length = 387
Score = 158 bits (397), Expect = 2e-037
Identities = 88/231 (38%), Positives = 137/231 (59%), Gaps = 10/231 (4%)
Frame = +2
Query: 5 EKGVVVGRLIFSDNGDMIDCTKMGMGGKAIPPNIDRVGDMQSDAMFILLVEKDAAYIRLA 184
EKG VVG + GD+ID +KMG G AI P D + + DA ++L+VEKDA + +L
Sbjct: 157 EKGKVVGNMRIRSGGDIIDLSKMGHGAYAIEPTPDLIEFIDVDAEYVLVVEKDAVFQQLH 216
Query: 185 EDRFYNRFPCIIVTAKGQPDVATRLFLRKMKMELKLPVLALVDSDPYGLKILSVYGCGSK 364
F+ + I++T+ GQPD ATR F+R++ EL LPV L D+DPYG I SV+ GS
Sbjct: 217 RIGFWKKHRAILITSAGQPDRATRRFVRRLNEELGLPVYILTDADPYGWYIYSVFKIGSI 276
Query: 365 NMSYYSANLTTPDIKWLGIRPSDLDKYK-----IPEQCR----LPMTEQDIKTGKDMLEE 517
+SY S L TP+ +++G+ +D+ YK + EQ R + E DIK ++
Sbjct: 277 TLSYESERLATPNARFIGVSMTDIFGYKSKKPYLTEQERRNFIIKAKEADIKRAYELKNY 336
Query: 518 DFVKKNPGWVEELNLMVKTKQKAEIQALSSFGFQYLSEVYLPLKLQQQDWL 670
+ + W E+++ ++ K K EI+A++S G ++L++ YLP K++ DW+
Sbjct: 337 KWFQTKK-WQIEIDIFLEKKAKLEIEAMTSKGLRFLADKYLPEKIETGDWI 386
>sp|Q9M4A1|SPO12_ARATH Meiotic recombination protein SPO11-2 OS=Arabidopsis
thaliana GN=SPO11-2 PE=1 SV=1
Length = 383
Score = 151 bits (379), Expect = 2e-035
Identities = 86/218 (39%), Positives = 135/218 (61%), Gaps = 10/218 (4%)
Frame = +2
Query: 11 GVVVGRLIFSDNG-DMIDCTKMGMGGKAIPPNIDRVGD--MQSDAMFILLVEKDAAYIRL 181
G+V GRL + G + +DC+ G G AI +++ + + M++DA +I++VEK A + RL
Sbjct: 166 GLVAGRLFLQEPGKEAVDCSACGSSGFAITGDLNLLDNTIMRTDARYIIIVEKHAIFHRL 225
Query: 182 AEDRFYNRFPCIIVTAKGQPDVATRLFLRKMKMEL-KLPVLALVDSDPYGLKILSVYGCG 358
EDR +N PC+ +TAKG PD+ATR FL +M LP+L LVD +P GL IL + G
Sbjct: 226 VEDRVFNHIPCVFITAKGYPDIATRFFLHRMSTTFPDLPILVLVDWNPAGLAILCTFKFG 285
Query: 359 SKNMSYYSANLTTPDIKWLGIRPSDLDKYKIPEQCRLPMTEQDIKTGKDMLEEDFVKKNP 538
S M A ++KW+G+R DL+ IPE+ +P+ +D + K +L +++N
Sbjct: 286 SIGMG-LEAYRYACNVKWIGLRGDDLN--LIPEESLVPLKPKDSQIAKSLLSSKILQEN- 341
Query: 539 GWVEELNLMVKTKQKAEIQALSSFGFQYLSEVYLPLKL 652
++EEL+LMV+T ++AEI+AL G+ YL + Y+ K+
Sbjct: 342 -YIEELSLMVQTGKRAEIEALYCHGYNYLGK-YIATKI 377
>sp|Q57815|TOP6A_METJA Type II DNA topoisomerase VI subunit A
OS=Methanocaldococcus jannaschii GN=top6A PE=1 SV=1
Length = 369
Score = 139 bits (350), Expect = 5e-032
Identities = 77/209 (36%), Positives = 123/209 (58%), Gaps = 7/209 (3%)
Frame = +2
Query: 53 MIDCTKMGMGGKAIPPNIDRVGDMQSDAMFILLVEKDAAYIRLAEDRFYNRFPCIIVTAK 232
++DCTK+G G IP ++ ++ ++++DA FIL +E + RL +RF+++ CI+V+ K
Sbjct: 164 VVDCTKLGTGAYNIPNDVTKL-NLETDADFILAIETSGMFARLNAERFWDKHNCILVSLK 222
Query: 233 GQPDVATRLFLRKMKMELKLPVLALVDSDPYG-LKILSVYGCGSKNMSYYSANLTTPDIK 409
G P ATR F++++ E LPVL D DPYG L I GS + + L+ P +
Sbjct: 223 GVPARATRRFIKRLHEEHDLPVLVFTDGDPYGYLNIYRTLKVGSGKAIHLADKLSIPAAR 282
Query: 410 WLGIRPSDLDKYKIPEQCRLPMTEQDIKTGKDMLE-EDFVKKNPGWVEELNLMVKTKQKA 586
+G+ P D+ Y +P P+ EQDIK KD L+ +DFV+ P W + L M+ +A
Sbjct: 283 LIGVTPQDIIDYDLPTH---PLKEQDIKRIKDGLKNDDFVRSFPEWQKALKQMLDMGVRA 339
Query: 587 EIQALSSFGFQYLSEVYLPLKLQQQD-WL 670
E Q+L+ +G +Y+ YLP K++ + WL
Sbjct: 340 EQQSLAKYGLKYVVNTYLPEKIKDESTWL 368
>sp|Q9YE67|TOP6A_AERPE Type II DNA topoisomerase VI subunit A OS=Aeropyrum
pernix GN=top6A PE=3 SV=2
Length = 389
Score = 134 bits (335), Expect = 3e-030
Identities = 68/148 (45%), Positives = 94/148 (63%)
Frame = +2
Query: 5 EKGVVVGRLIFSDNGDMIDCTKMGMGGKAIPPNIDRVGDMQSDAMFILLVEKDAAYIRLA 184
EKG VVG + GD+ID +K+G G AI P D + + DA F+L+VEKDA + +L
Sbjct: 158 EKGKVVGNMRIRSGGDVIDLSKLGHGAYAIEPTPDLIEFLDVDAEFVLVVEKDAVFQQLH 217
Query: 185 EDRFYNRFPCIIVTAKGQPDVATRLFLRKMKMELKLPVLALVDSDPYGLKILSVYGCGSK 364
F+ ++ ++VT GQPD ATR F+R++ ELKLPV + DSDPYG I SVY GS
Sbjct: 218 RAGFWKKYKALLVTGSGQPDRATRRFVRRLHEELKLPVYIITDSDPYGWYIYSVYKVGSI 277
Query: 365 NMSYYSANLTTPDIKWLGIRPSDLDKYK 448
+SY S L TP K+LG++ +D+ Y+
Sbjct: 278 TLSYESERLATPKAKFLGVQMTDIFGYR 305
>sp|O29322|TOP6A_ARCFU Type II DNA topoisomerase VI subunit A OS=Archaeoglobus
fulgidus GN=top6A PE=3 SV=1
Length = 360
Score = 133 bits (334), Expect = 4e-030
Identities = 71/196 (36%), Positives = 115/196 (58%), Gaps = 4/196 (2%)
Frame = +2
Query: 71 MGMGGKAIPPNIDRVGDMQSDAMFILLVEKDAAYIRLAEDRFYNRFPCIIVTAKGQPDVA 250
+G GG IP N+D++ + DA F++ +E RL E+ F ++ IIV KGQP +
Sbjct: 165 VGEGGYQIPVNVDKIEFVDHDAKFVIAIETGGMRDRLVENGFDEKYDAIIVHLKGQPARS 224
Query: 251 TRLFLRKMKMELKLPVLALVDSDPYGLKILSVYGCGSKNMSYYSANLTTPDIKWLGIRPS 430
TR LR++ EL LPV+ D DP+ +I + GS ++ S L TP +++GIRP+
Sbjct: 225 TRRLLRRLNTELNLPVVVFTDGDPWSYRIFASVAYGSIKSAHLSEYLATPAAQFVGIRPT 284
Query: 431 DLDKYKIPEQCRLPMTEQDIKTGKDMLEEDFVKKNPGWVEELNLMVKTKQKAEIQALSSF 610
D+ KY +P +TE+DIK +L + + W +E+NL ++ +K+E QAL+ +
Sbjct: 285 DIVKYDLPAD---KLTEEDIKALNAILTDPRF-DSEFWKKEVNLQLEINKKSEQQALAKY 340
Query: 611 GFQYLSEVYLPLKLQQ 658
G Y+++VYLP +L +
Sbjct: 341 GLDYVTDVYLPERLSE 356
>sp|O05208|TOP6A_SULSH Type II DNA topoisomerase VI subunit A OS=Sulfolobus
shibatae GN=top6A PE=1 SV=1
Length = 389
Score = 130 bits (325), Expect = 4e-029
Identities = 67/144 (46%), Positives = 91/144 (63%)
Frame = +2
Query: 5 EKGVVVGRLIFSDNGDMIDCTKMGMGGKAIPPNIDRVGDMQSDAMFILLVEKDAAYIRLA 184
EKG VVG L D+ID +K G G AI P D + + DA F+L+VEKDA + +L
Sbjct: 159 EKGKVVGNLRIRSGNDVIDLSKTGHGAYAIEPTPDLIDFIDVDAEFVLVVEKDAVFQQLH 218
Query: 185 EDRFYNRFPCIIVTAKGQPDVATRLFLRKMKMELKLPVLALVDSDPYGLKILSVYGCGSK 364
F+ ++ I++T+ GQPD ATR F+R++ ELKLPV L D+DPYG I SV+ GS
Sbjct: 219 RAGFWKQYKSILITSAGQPDRATRRFVRRLNEELKLPVYILTDADPYGWYIFSVFRIGSI 278
Query: 365 NMSYYSANLTTPDIKWLGIRPSDL 436
++SY S L TPD K+LG+ D+
Sbjct: 279 SLSYESERLATPDAKFLGVSMGDI 302
>sp|Q971T1|TOP6A_SULTO Type II DNA topoisomerase VI subunit A OS=Sulfolobus
tokodaii GN=top6A PE=3 SV=1
Length = 387
Score = 126 bits (316), Expect = 5e-028
Identities = 65/144 (45%), Positives = 93/144 (64%)
Frame = +2
Query: 5 EKGVVVGRLIFSDNGDMIDCTKMGMGGKAIPPNIDRVGDMQSDAMFILLVEKDAAYIRLA 184
EKG VVG + D+ID +KMG G +I P D + + +A F+L+VEKDA + +L
Sbjct: 157 EKGKVVGDMRIRSGNDIIDLSKMGHGAYSIEPTPDLIDFVDINAEFVLVVEKDAVFQQLH 216
Query: 185 EDRFYNRFPCIIVTAKGQPDVATRLFLRKMKMELKLPVLALVDSDPYGLKILSVYGCGSK 364
F+ ++ I+VT+ GQPD ATR F+R++ ELKLPV L D+DPYG I SV+ GS
Sbjct: 217 RAGFWKQYKAILVTSAGQPDRATRRFVRRLNEELKLPVYILTDADPYGWYIYSVFRIGSI 276
Query: 365 NMSYYSANLTTPDIKWLGIRPSDL 436
++SY S L TP+ K+LG+ +D+
Sbjct: 277 SLSYESERLATPNAKFLGVSMTDI 300
>sp|Q5V4R4|TOP6A_HALMA Type II DNA topoisomerase VI subunit A OS=Haloarcula
marismortui GN=top6A PE=3 SV=1
Length = 368
Score = 122 bits (306), Expect = 7e-027
Identities = 66/196 (33%), Positives = 110/196 (56%), Gaps = 4/196 (2%)
Frame = +2
Query: 71 MGMGGKAIPPNIDRVGDMQSDAMFILLVEKDAAYIRLAEDRFYNRFPCIIVTAKGQPDVA 250
+G GG IP N D + + +DA F+L VE RL E+ F + + ++V GQP A
Sbjct: 173 VGQGGYQIPNNPDTIEFLDNDAKFVLCVETGGMRDRLVENGFDDEYDALVVHLGGQPARA 232
Query: 251 TRLFLRKMKMELKLPVLALVDSDPYGLKILSVYGCGSKNMSYYSANLTTPDIKWLGIRPS 430
TR ++++ EL LPV D DP+ +I GS ++ S L TP+ +++GIRP
Sbjct: 233 TRRLIKRLHDELDLPVTVFTDGDPWSYRIFGSVSYGSIKSAHLSEYLATPEAQFIGIRPE 292
Query: 431 DLDKYKIPEQCRLPMTEQDIKTGKDMLEEDFVKKNPGWVEELNLMVKTKQKAEIQALSSF 610
D+ +Y++P P+++ D+ + LE+ + + W E++ L + +KAE QAL+S
Sbjct: 293 DIVEYELPTD---PLSDSDVNALESELEDPRFQTD-FWEEQIELQLDINKKAEQQALASR 348
Query: 611 GFQYLSEVYLPLKLQQ 658
G +++E YLP +L +
Sbjct: 349 GLDFVTETYLPERLDE 364
>sp|Q8PUB7|TOP6A_METMA Type II DNA topoisomerase VI subunit A OS=Methanosarcina
mazei GN=top6A PE=1 SV=1
Length = 369
Score = 118 bits (294), Expect = 2e-025
Identities = 66/202 (32%), Positives = 112/202 (55%), Gaps = 5/202 (2%)
Frame = +2
Query: 56 IDCTK-MGMGGKAIPPNIDRVGDMQSDAMFILLVEKDAAYIRLAEDRFYNRFPCIIVTAK 232
I C K +G GG IP N++ + + DA I+ +E Y RL E+ F + I+V K
Sbjct: 168 IHCQKDVGEGGYQIPFNVENIEFQKHDASMIIAIETGGMYARLMENGFDEAYNAILVHLK 227
Query: 233 GQPDVATRLFLRKMKMELKLPVLALVDSDPYGLKILSVYGCGSKNMSYYSANLTTPDIKW 412
GQP +TR +++M EL +PV D DP+ +I + G+ ++ S + TP K+
Sbjct: 228 GQPARSTRRIIKRMNEELGIPVAVFTDGDPWSYRIYASVAYGAIKSAHLSEFMATPAAKF 287
Query: 413 LGIRPSDLDKYKIPEQCRLPMTEQDIKTGKDMLEEDFVKKNPGWVEELNLMVKTKQKAEI 592
LG++PSD+ +Y++ +TEQD+ + L + + + W E++ L + +KAE
Sbjct: 288 LGLQPSDIVEYELSTD---KLTEQDVSALRSELSDPRFESD-YWKEQIQLQLDIGKKAEQ 343
Query: 593 QALSSFGFQYLSEVYLPLKLQQ 658
QA + G +++EVYLP +L++
Sbjct: 344 QAFAGKGLDFVTEVYLPNRLKE 365
>sp|Q3IPW7|TOP6A_NATPD Type 2 DNA topoisomerase 6 subunit A OS=Natronomonas
pharaonis (strain DSM 2160 / ATCC 35678) GN=top6A PE=3 SV=1
Length = 368
Score = 117 bits (293), Expect = 2e-025
Identities = 70/200 (35%), Positives = 112/200 (56%), Gaps = 5/200 (2%)
Frame = +2
Query: 56 IDCTK-MGMGGKAIPPNIDRVGDMQSDAMFILLVEKDAAYIRLAEDRFYNRFPCIIVTAK 232
I C K +G GG IP N D + + +DA F+L VE RL E+ F IIV K
Sbjct: 167 IHCQKDVGEGGYQIPNNPDTIEFLDNDADFVLCVETGGMRDRLVENGFDEEHNVIIVHLK 226
Query: 233 GQPDVATRLFLRKMKMELKLPVLALVDSDPYGLKILSVYGCGSKNMSYYSANLTTPDIKW 412
GQP ATR +++ +L LPV+ D DP+ +I + GS ++ S L TP+ ++
Sbjct: 227 GQPARATRRITKRLHDDLDLPVVVFCDGDPWSYRIYASVAYGSIKSAHLSEYLATPEAEY 286
Query: 413 LGIRPSDLDKYKIPEQCRLPMTEQDIKTGKDMLEEDFVKKNPGWVEELNLMVKTKQKAEI 592
+GI+P+D+ +Y +P P+++ DI + L++ ++ W E++ L + +KAE
Sbjct: 287 IGIQPADIVEYDLPTD---PLSDSDINALESELDDPRF-QDDYWREQIELQLDIGKKAEQ 342
Query: 593 QALSSFGFQYLSEVYLPLKL 652
QAL+S G +++E YLP +L
Sbjct: 343 QALASRGLDFVTETYLPERL 362
>sp|B0R4D2|TOP6A_HALS3 Type 2 DNA topoisomerase 6 subunit A OS=Halobacterium
salinarum (strain ATCC 29341 / DSM 671 / R1) GN=top6A PE=3 SV=1
Length = 366
Score = 117 bits (292), Expect = 3e-025
Identities = 66/196 (33%), Positives = 106/196 (54%), Gaps = 4/196 (2%)
Frame = +2
Query: 71 MGMGGKAIPPNIDRVGDMQSDAMFILLVEKDAAYIRLAEDRFYNRFPCIIVTAKGQPDVA 250
+G GG IP N D + + +DA F+L VE RL E+ F + + I+V GQP A
Sbjct: 171 VGQGGYQIPNNPDTIDFLDTDADFVLCVETGGMRDRLVENGFDDDYNAIVVHLGGQPARA 230
Query: 251 TRLFLRKMKMELKLPVLALVDSDPYGLKILSVYGCGSKNMSYYSANLTTPDIKWLGIRPS 430
TR +++ EL LPV D DP+ +I GS ++ S L TP +++GIRP
Sbjct: 231 TRRLTKRLHDELDLPVTVFTDGDPWSYRIYGSVAYGSIKSAHLSEYLATPQAQFIGIRPQ 290
Query: 431 DLDKYKIPEQCRLPMTEQDIKTGKDMLEEDFVKKNPGWVEELNLMVKTKQKAEIQALSSF 610
D+ Y +P P+++ D+ + LE+ + + W E++ L + +KAE QAL+S
Sbjct: 291 DIVDYDLPTD---PLSDSDVNALESELEDPRFQSD-FWTEQIGLQLDIDKKAEQQALASR 346
Query: 611 GFQYLSEVYLPLKLQQ 658
G ++++ YLP +L +
Sbjct: 347 GLDFVTDTYLPERLAE 362
>sp|Q9HR32|TOP6A_HALSA Type II DNA topoisomerase VI subunit A OS=Halobacterium
salinarium GN=top6A PE=3 SV=1
Length = 366
Score = 117 bits (292), Expect = 3e-025
Identities = 66/196 (33%), Positives = 106/196 (54%), Gaps = 4/196 (2%)
Frame = +2
Query: 71 MGMGGKAIPPNIDRVGDMQSDAMFILLVEKDAAYIRLAEDRFYNRFPCIIVTAKGQPDVA 250
+G GG IP N D + + +DA F+L VE RL E+ F + + I+V GQP A
Sbjct: 171 VGQGGYQIPNNPDTIDFLDTDADFVLCVETGGMRDRLVENGFDDDYNAIVVHLGGQPARA 230
Query: 251 TRLFLRKMKMELKLPVLALVDSDPYGLKILSVYGCGSKNMSYYSANLTTPDIKWLGIRPS 430
TR +++ EL LPV D DP+ +I GS ++ S L TP +++GIRP
Sbjct: 231 TRRLTKRLHDELDLPVTVFTDGDPWSYRIYGSVAYGSIKSAHLSEYLATPQAQFIGIRPQ 290
Query: 431 DLDKYKIPEQCRLPMTEQDIKTGKDMLEEDFVKKNPGWVEELNLMVKTKQKAEIQALSSF 610
D+ Y +P P+++ D+ + LE+ + + W E++ L + +KAE QAL+S
Sbjct: 291 DIVDYDLPTD---PLSDSDVNALESELEDPRFQSD-FWTEQIGLQLDIDKKAEQQALASR 346
Query: 611 GFQYLSEVYLPLKLQQ 658
G ++++ YLP +L +
Sbjct: 347 GLDFVTDTYLPERLAE 362
>sp|Q8TQF8|TOP6A_METAC Type II DNA topoisomerase VI subunit A OS=Methanosarcina
acetivorans GN=top6A PE=3 SV=2
Length = 373
Score = 117 bits (292), Expect = 3e-025
Identities = 66/202 (32%), Positives = 112/202 (55%), Gaps = 5/202 (2%)
Frame = +2
Query: 56 IDCTK-MGMGGKAIPPNIDRVGDMQSDAMFILLVEKDAAYIRLAEDRFYNRFPCIIVTAK 232
I C K +G GG IP N++ + DA I+ +E Y RL E+ F + I+V K
Sbjct: 172 IHCQKDVGEGGYQIPFNVENIEFKNHDASMIIAIETGGMYARLMENGFDEAYNAILVHLK 231
Query: 233 GQPDVATRLFLRKMKMELKLPVLALVDSDPYGLKILSVYGCGSKNMSYYSANLTTPDIKW 412
GQP +TR +++M EL++PV D DP+ +I + G+ ++ S + TP ++
Sbjct: 232 GQPARSTRRIIKRMNEELEIPVAVFTDGDPWSYRIYASVAYGAIKSAHLSEFMATPAARF 291
Query: 413 LGIRPSDLDKYKIPEQCRLPMTEQDIKTGKDMLEEDFVKKNPGWVEELNLMVKTKQKAEI 592
LG++PSD+ +Y++ +TEQDI + L + ++ W E++ L + +KAE
Sbjct: 292 LGLQPSDIVEYELSTD---KLTEQDISALRSELSDPRF-ESEYWKEQIQLQLDIGKKAEQ 347
Query: 593 QALSSFGFQYLSEVYLPLKLQQ 658
QA + G +++EVYLP +L++
Sbjct: 348 QAFAGKGLDFVTEVYLPNRLKE 369
>sp|Q468I6|TOP6A_METBF Type 2 DNA topoisomerase 6 subunit A OS=Methanosarcina
barkeri (strain Fusaro / DSM 804) GN=top6A PE=3 SV=1
Length = 369
Score = 117 bits (292), Expect = 3e-025
Identities = 67/202 (33%), Positives = 111/202 (54%), Gaps = 5/202 (2%)
Frame = +2
Query: 56 IDCTK-MGMGGKAIPPNIDRVGDMQSDAMFILLVEKDAAYIRLAEDRFYNRFPCIIVTAK 232
I C K +G GG IP N++ + DA I+ +E Y RL E+ F + I+V K
Sbjct: 168 IHCQKDVGEGGYQIPFNVENIEFKAHDASMIIAIETGGMYARLMENGFDEAYNAILVHLK 227
Query: 233 GQPDVATRLFLRKMKMELKLPVLALVDSDPYGLKILSVYGCGSKNMSYYSANLTTPDIKW 412
GQP +TR +++M EL +PV D DP+ +I + G+ ++ S + TP K+
Sbjct: 228 GQPARSTRRIIKRMNEELGIPVAVFTDGDPWSYRIYASVAYGAIKSAHLSEFMATPAAKF 287
Query: 413 LGIRPSDLDKYKIPEQCRLPMTEQDIKTGKDMLEEDFVKKNPGWVEELNLMVKTKQKAEI 592
LG++PSD+ +Y++ +TEQDI + L + + + W E++ L + +KAE
Sbjct: 288 LGLQPSDIVEYELSTD---KLTEQDINALRSELSDPRFESD-YWKEQIQLQLDIGKKAEQ 343
Query: 593 QALSSFGFQYLSEVYLPLKLQQ 658
QA + G +++EVYLP +L++
Sbjct: 344 QAFAGKGLNFVTEVYLPNRLKE 365
>sp|Q5JH82|TOP6A_PYRKO Type II DNA topoisomerase VI subunit A OS=Pyrococcus
kodakaraensis GN=top6A PE=3 SV=1
Length = 385
Score = 112 bits (278), Expect = 1e-023
Identities = 68/229 (29%), Positives = 120/229 (52%), Gaps = 8/229 (3%)
Frame = +2
Query: 8 KGVVVGRLIFSDNGDMIDCTKMGMGGKAIPPNIDRVGDMQSDAMFILLVEKDAAYIRLAE 187
+G + G ++ D D + +++G GG A+P ++ + + + + L+VE A RL E
Sbjct: 156 RGYIYGDIVIRDGEDEFNASRLGSGGWAVPGTVEHIQFPEINVDYALVVETAAMADRLIE 215
Query: 188 DRFYNRFPCIIVTAKGQPDVATRLFLRKMKMELKLPVLALVDSDPYGLKILSVYGCGSKN 367
++F R +I+ +GQ R + ++ E LP++ D DPYG I S GS N
Sbjct: 216 EKFPKRENALIIATQGQASRGVRRLIHRLHYEEGLPIIVFTDGDPYGWYIYSTIKQGSIN 275
Query: 368 MSYYSANLTTPDIKWLGIRPSDLDKY---KIPEQCR-LPMTEQDIKTG--KDMLEEDFVK 529
++Y S L TP+ K++G+ D+ KY + E+ + +P ++ TG K +LEE
Sbjct: 276 LAYLSDKLATPESKFVGMTMDDIKKYGLENVTEKLKGIPPNKKGGPTGDYKRILEEMNYP 335
Query: 530 --KNPGWVEELNLMVKTKQKAEIQALSSFGFQYLSEVYLPLKLQQQDWL 670
+N W +L L +K + E QAL++ +++++ YLP K+ D L
Sbjct: 336 WFQNKEWQRQLQLALKWGVRIEQQALANKSLEFVAKEYLPEKINNGDLL 384
Database: UniProt/SwissProt
Posted date: Sat Aug 07 14:36:18 2010
Number of letters in database: 182,829,261
Number of sequences in database: 518,415
Lambda K H
0.267 0.041 0.140
Gapped
Lambda K H
0.267 0.041 0.140
Matrix: blosum62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 116,323,427,680
Number of Sequences: 518415
Number of Extensions: 116323427680
Number of Successful Extensions: 743337835
Number of sequences better than 0.0: 0
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