BLASTX 7.6.2
Query= UN28105 /QuerySize=869
(868 letters)
Database: UniProt/SwissProt;
518,415 sequences; 182,829,261 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q55G10|PNCB_DICDI Nicotinate phosphoribosyltransferase OS=Dic... 285 4e-076
sp|Q9VQX4|PNCB_DROME Nicotinate phosphoribosyltransferase OS=Dro... 284 7e-076
sp|Q95XX1|PNCB_CAEEL Nicotinate phosphoribosyltransferase OS=Cae... 270 1e-071
sp|Q6P3H4|PNCB_DANRE Nicotinate phosphoribosyltransferase OS=Dan... 260 2e-068
sp|A5PK51|PNCB_BOVIN Nicotinate phosphoribosyltransferase OS=Bos... 257 1e-067
sp|Q6XQN6|PNCB_HUMAN Nicotinate phosphoribosyltransferase OS=Hom... 255 5e-067
sp|Q8CC86|PNCB_MOUSE Nicotinate phosphoribosyltransferase OS=Mus... 247 8e-065
sp|Q6XQN1|PNCB_RAT Nicotinate phosphoribosyltransferase OS=Rattu... 247 1e-064
sp|O32090|PNCB_BACSU Nicotinate phosphoribosyltransferase OS=Bac... 183 1e-045
sp|O53770|PNCB2_MYCTU Nicotinate phosphoribosyltransferase pncB2... 145 5e-034
sp|Q10641|PNCB1_MYCTU Nicotinate phosphoribosyltransferase pncB1... 104 8e-022
>sp|Q55G10|PNCB_DICDI Nicotinate phosphoribosyltransferase OS=Dictyostelium
discoideum GN=naprt PE=2 SV=1
Length = 589
Score = 285 bits (727), Expect = 4e-076
Identities = 135/227 (59%), Positives = 172/227 (75%)
Frame = +1
Query: 109 PTNPMVTPLLNDLYQFTMAYAYWKAGKQNERSVFDLYFRKNPFGGEYTVFAGLDECIKFL 288
P N VTPLL DLYQ TMAY+ WK + +VFDLYFRK+PFGGE+TVFAGL+E I+F+
Sbjct: 55 PLNGFVTPLLTDLYQITMAYSLWKNNRHEIPAVFDLYFRKSPFGGEFTVFAGLEEVIRFV 114
Query: 289 ASFKLTHQEIDYVRDSLPGSEEAFCDYLRGLDCSDVEVYAIPEGSVVFPKVPLMRVEGPV 468
+ F T +E+ ++++ +P E+ F DYL LD S V +YA+ EGSVVFP+VPL+RVEGP+
Sbjct: 115 SDFHYTKEEVGFIKEMIPDCEQEFLDYLSKLDSSSVTLYAMKEGSVVFPRVPLLRVEGPM 174
Query: 469 GVVQLLETPFLNLVNFASLVATNAARHRFVAGKSKSLLEFGARRAQGPDGAISASKYCYL 648
+ QL ET L LVNFASLVATNAARHR GK K +LEFG RRAQGPDGA+SAS+Y YL
Sbjct: 175 ILCQLFETTLLCLVNFASLVATNAARHRLAVGKEKVMLEFGLRRAQGPDGAMSASRYSYL 234
Query: 649 GGFDATSNVAAGKLFGIPLRGTHSHAFVSSFMSTDEIVDKVLKSADG 789
GG D TSNV A FGIP+RGTH+H+F++++ DE++D +K +G
Sbjct: 235 GGADGTSNVLAHCFFGIPIRGTHAHSFITNYSGPDELLDASIKDTNG 281
>sp|Q9VQX4|PNCB_DROME Nicotinate phosphoribosyltransferase OS=Drosophila
melanogaster GN=CG3714 PE=2 SV=2
Length = 555
Score = 284 bits (725), Expect = 7e-076
Identities = 139/243 (57%), Positives = 182/243 (74%), Gaps = 4/243 (1%)
Frame = +1
Query: 61 MEPKENGNQPGRVMEG---PTNPMVTPLLNDLYQFTMAYAYWKAGKQNERSVFDLYFRKN 231
M +E G G+ M+ N +V PLL DLYQ TMAYAYWK+ K ++ +VFDL+FR N
Sbjct: 1 MNDRELGCAGGQFMDRGRMNQNGVVQPLLTDLYQITMAYAYWKSDKTDDTAVFDLFFRNN 60
Query: 232 PFGGEYTVFAGLDECIKFLASFKLTHQEIDYVRDSLP-GSEEAFCDYLRGLDCSDVEVYA 408
PF GE+T+FAGL+EC+KFL SF + +I+Y++ +LP G E F +YL L DV +YA
Sbjct: 61 PFHGEFTIFAGLEECLKFLDSFHYSQSDIEYLKQTLPEGIEHEFFEYLGNLTARDVTLYA 120
Query: 409 IPEGSVVFPKVPLMRVEGPVGVVQLLETPFLNLVNFASLVATNAARHRFVAGKSKSLLEF 588
I EG+V FP+VP++++EGP+ +VQLLET L LVN+ASL+ATNAAR+R VAGK LLEF
Sbjct: 121 IDEGTVAFPRVPIIKIEGPLIIVQLLETTLLTLVNYASLMATNAARYRMVAGKHVKLLEF 180
Query: 589 GARRAQGPDGAISASKYCYLGGFDATSNVAAGKLFGIPLRGTHSHAFVSSFMSTDEIVDK 768
G RRAQGPDG +SASKY Y GGFD TSNV AGKLF IP++GTH+HA+++SF S E+ +
Sbjct: 181 GLRRAQGPDGGLSASKYSYTGGFDGTSNVLAGKLFNIPVKGTHAHAYITSFSSIGELKTR 240
Query: 769 VLK 777
++K
Sbjct: 241 LIK 243
>sp|Q95XX1|PNCB_CAEEL Nicotinate phosphoribosyltransferase OS=Caenorhabditis
elegans GN=Y54G2A.17 PE=2 SV=2
Length = 563
Score = 270 bits (688), Expect = 1e-071
Identities = 128/219 (58%), Positives = 168/219 (76%), Gaps = 1/219 (0%)
Frame = +1
Query: 121 MVTPLLNDLYQFTMAYAYWKAGKQNERSVFDLYFRKNPFGGEYTVFAGLDECIKFLASFK 300
+V PLL D YQ TM YAYWK G NE +VFD++FRKNPF GE+TVFAGL++C++F+ +FK
Sbjct: 27 LVQPLLTDFYQITMCYAYWKTGTHNEPAVFDVFFRKNPFQGEFTVFAGLEDCLRFVENFK 86
Query: 301 LTHQEIDYVRDSLP-GSEEAFCDYLRGLDCSDVEVYAIPEGSVVFPKVPLMRVEGPVGVV 477
+ +IDYV+ LP +E F +YL L+ S + + A+ EGSVVFPKVPL+ + GP+ +
Sbjct: 87 FSQSDIDYVKKILPENAEPEFYEYLETLNGSHLTIEAVAEGSVVFPKVPLLTINGPLAMC 146
Query: 478 QLLETPFLNLVNFASLVATNAARHRFVAGKSKSLLEFGARRAQGPDGAISASKYCYLGGF 657
QL+ET LNLVN+ASLVATNAAR R +G LLEFG RRAQGP+G ++ASKYCY+GGF
Sbjct: 147 QLIETSILNLVNYASLVATNAARFRQASGWKIQLLEFGLRRAQGPNGGLTASKYCYIGGF 206
Query: 658 DATSNVAAGKLFGIPLRGTHSHAFVSSFMSTDEIVDKVL 774
DATSNV AGKL+GIP++GT +H+F+ SF S E+ ++L
Sbjct: 207 DATSNVLAGKLYGIPVKGTQAHSFICSFSSPAELKVRLL 245
>sp|Q6P3H4|PNCB_DANRE Nicotinate phosphoribosyltransferase OS=Danio rerio
GN=naprt1 PE=2 SV=2
Length = 546
Score = 260 bits (662), Expect = 2e-068
Identities = 129/241 (53%), Positives = 173/241 (71%), Gaps = 4/241 (1%)
Frame = +1
Query: 124 VTPLLNDLYQFTMAYAYWKAGKQNERSVFDLYFRKNPFGGEYTVFAGLDECIKFLASFKL 303
V PLL DLYQ MAYAYW+AG+ NE +VF+L+FR NPFGG +++FAGL +C+ FL +F
Sbjct: 14 VPPLLTDLYQ--MAYAYWRAGRHNEPAVFELFFRDNPFGGGFSLFAGLSDCLLFLQNFSF 71
Query: 304 THQEIDYVRDSLPGSEEA-FCDYLRGLDCSDVEVYAIPEGSVVFPKVPLMRVEGPVGVVQ 480
+ ++ Y+R LP +A F YL+ LDCS V V A+PEGSVVF +VPL+ V GP+ VVQ
Sbjct: 72 SDDDVQYLRSVLPADTDAGFFSYLKELDCSCVSVSAVPEGSVVFARVPLLEVSGPLAVVQ 131
Query: 481 LLETPFLNLVNFASLVATNAARHRFVAGKSKSLLEFGARRAQGPDGAISASKYCYLGGFD 660
LLET L LVN+ASLV +NAAR R AG + L+E G RRAQGPDG ++AS+Y Y+GGFD
Sbjct: 132 LLETSLLCLVNYASLVCSNAARFRLAAGPRRRLMEMGLRRAQGPDGGLTASRYTYIGGFD 191
Query: 661 ATSNVAAGKLFGIPLRGTHSHAFVSSFMSTDEIVDKVLKSADGKTTCDDFASLVQTWLTK 840
TSN AG+L+GIP+ GT +H++++SF S +E+ + LK G + DF LV+ L +
Sbjct: 192 LTSNALAGRLYGIPVAGTMAHSYITSFSSLEEVWPQTLKPCGGGDSI-DFICLVKGLLGR 250
Query: 841 I 843
+
Sbjct: 251 V 251
>sp|A5PK51|PNCB_BOVIN Nicotinate phosphoribosyltransferase OS=Bos taurus
GN=NAPRT1 PE=2 SV=2
Length = 538
Score = 257 bits (655), Expect = 1e-067
Identities = 125/239 (52%), Positives = 176/239 (73%), Gaps = 1/239 (0%)
Frame = +1
Query: 130 PLLNDLYQFTMAYAYWKAGKQNERSVFDLYFRKNPFGGEYTVFAGLDECIKFLASFKLTH 309
PLL DLYQ TMA YW+AG+ +++ F+L+FR+ PFGG + + AGL +C++FL +F+L
Sbjct: 15 PLLTDLYQATMALGYWRAGRAQDQAEFELFFRQCPFGGAFALAAGLRDCVRFLRAFRLRD 74
Query: 310 QEIDYVRDSL-PGSEEAFCDYLRGLDCSDVEVYAIPEGSVVFPKVPLMRVEGPVGVVQLL 486
++ ++ +L P ++ AF ++LR LDCS V V A+PEGS+ FP VPL++V GP+ VVQLL
Sbjct: 75 ADVQFLASALPPDTDPAFFEHLRALDCSGVTVRALPEGSLAFPGVPLLQVSGPLLVVQLL 134
Query: 487 ETPFLNLVNFASLVATNAARHRFVAGKSKSLLEFGARRAQGPDGAISASKYCYLGGFDAT 666
ETP L LV++ASL+ATNAAR R +AG K LLE G RRAQGPDG ++AS Y YLGGFDA+
Sbjct: 135 ETPLLCLVSYASLIATNAARLRLIAGPDKRLLEMGLRRAQGPDGGLTASTYSYLGGFDAS 194
Query: 667 SNVAAGKLFGIPLRGTHSHAFVSSFMSTDEIVDKVLKSADGKTTCDDFASLVQTWLTKI 843
SNV AG+L G+P+ GT +H+FV+SF ++ D +L A G+ + D A+ V+ WL ++
Sbjct: 195 SNVLAGQLRGVPVAGTLAHSFVTSFSGSEVPPDPMLAPAAGQGSQVDLAASVEMWLERV 253
>sp|Q6XQN6|PNCB_HUMAN Nicotinate phosphoribosyltransferase OS=Homo sapiens
GN=NAPRT1 PE=1 SV=2
Length = 538
Score = 255 bits (649), Expect = 5e-067
Identities = 125/239 (52%), Positives = 173/239 (72%), Gaps = 1/239 (0%)
Frame = +1
Query: 130 PLLNDLYQFTMAYAYWKAGKQNERSVFDLYFRKNPFGGEYTVFAGLDECIKFLASFKLTH 309
PLL DLYQ TMA YW+AG+ + + F+L+FR+ PFGG + + AGL +C++FL +F+L
Sbjct: 15 PLLTDLYQATMALGYWRAGRARDAAEFELFFRRCPFGGAFALAAGLRDCVRFLRAFRLRD 74
Query: 310 QEIDYVRDSL-PGSEEAFCDYLRGLDCSDVEVYAIPEGSVVFPKVPLMRVEGPVGVVQLL 486
++ ++ L P ++ AF ++LR LDCS+V V A+PEGS+ FP VPL++V GP+ VVQLL
Sbjct: 75 ADVQFLASVLPPDTDPAFFEHLRALDCSEVTVRALPEGSLAFPGVPLLQVSGPLLVVQLL 134
Query: 487 ETPFLNLVNFASLVATNAARHRFVAGKSKSLLEFGARRAQGPDGAISASKYCYLGGFDAT 666
ETP L LV++ASLVATNAAR R +AG K LLE G RRAQGPDG ++AS Y YLGGFD++
Sbjct: 135 ETPLLCLVSYASLVATNAARLRLIAGPEKRLLEMGLRRAQGPDGGLTASTYSYLGGFDSS 194
Query: 667 SNVAAGKLFGIPLRGTHSHAFVSSFMSTDEIVDKVLKSADGKTTCDDFASLVQTWLTKI 843
SNV AG+L G+P+ GT +H+FV+SF ++ D +L A G+ D A+ Q WL ++
Sbjct: 195 SNVLAGQLRGVPVAGTLAHSFVTSFSGSEVPPDPMLAPAAGEGPGVDLAAKAQVWLEQV 253
>sp|Q8CC86|PNCB_MOUSE Nicotinate phosphoribosyltransferase OS=Mus musculus
GN=Naprt1 PE=2 SV=1
Length = 538
Score = 247 bits (630), Expect = 8e-065
Identities = 123/242 (50%), Positives = 169/242 (69%), Gaps = 1/242 (0%)
Frame = +1
Query: 121 MVTPLLNDLYQFTMAYAYWKAGKQNERSVFDLYFRKNPFGGEYTVFAGLDECIKFLASFK 300
+V PLL DLYQ TMA YW+AG+ E + F+L+FR PFGG + + AGL +C++FL +F+
Sbjct: 12 VVRPLLTDLYQATMALGYWRAGRACEAAEFELFFRHCPFGGSFALSAGLQDCMRFLRAFR 71
Query: 301 LTHQEIDYVRDSL-PGSEEAFCDYLRGLDCSDVEVYAIPEGSVVFPKVPLMRVEGPVGVV 477
L ++ ++ L P ++ AF ++LR LDCS V V A+PEGS+ FP VPL++V GP+ +V
Sbjct: 72 LRDADVQFLASVLPPDTDPAFFEHLRALDCSGVTVRALPEGSLAFPGVPLLQVSGPLLLV 131
Query: 478 QLLETPFLNLVNFASLVATNAARHRFVAGKSKSLLEFGARRAQGPDGAISASKYCYLGGF 657
QLLETP L LV++ASLVATNAAR R +AG K LLE G RRAQGPDG +AS Y YLGGF
Sbjct: 132 QLLETPLLCLVSYASLVATNAARLRLIAGPDKKLLEMGLRRAQGPDGGFTASIYSYLGGF 191
Query: 658 DATSNVAAGKLFGIPLRGTHSHAFVSSFMSTDEIVDKVLKSADGKTTCDDFASLVQTWLT 837
D++SN AG+L G+P+ GT +H+FV+SF ++ D +L A + D + V WL
Sbjct: 192 DSSSNTLAGQLRGVPVAGTLAHSFVTSFSGSEVPPDPMLAPASSEGPTVDLPARVNLWLK 251
Query: 838 KI 843
++
Sbjct: 252 RV 253
>sp|Q6XQN1|PNCB_RAT Nicotinate phosphoribosyltransferase OS=Rattus norvegicus
GN=Naprt1 PE=2 SV=1
Length = 538
Score = 247 bits (629), Expect = 1e-064
Identities = 122/242 (50%), Positives = 168/242 (69%), Gaps = 1/242 (0%)
Frame = +1
Query: 121 MVTPLLNDLYQFTMAYAYWKAGKQNERSVFDLYFRKNPFGGEYTVFAGLDECIKFLASFK 300
+V PLL DLYQ TM YW+AG+ E + F+L+FR PFGG + + AGL +CI+FL +F+
Sbjct: 12 VVRPLLTDLYQATMGLGYWRAGRACEEAEFELFFRHCPFGGSFALTAGLQDCIRFLRAFR 71
Query: 301 LTHQEIDYVRDSL-PGSEEAFCDYLRGLDCSDVEVYAIPEGSVVFPKVPLMRVEGPVGVV 477
L ++ ++ L P ++ AF ++LR LDCS V V A+PEGS+ FP VPL++V GP+ +V
Sbjct: 72 LRDADVQFLASVLPPDTDPAFFEHLRALDCSRVSVRALPEGSLAFPGVPLLQVSGPLLLV 131
Query: 478 QLLETPFLNLVNFASLVATNAARHRFVAGKSKSLLEFGARRAQGPDGAISASKYCYLGGF 657
QLLETP L LV++ASLVATNAAR R +AG K LLE G RRAQGPDG +AS Y YLGGF
Sbjct: 132 QLLETPLLCLVSYASLVATNAARLRLIAGPDKRLLEMGLRRAQGPDGGFTASIYSYLGGF 191
Query: 658 DATSNVAAGKLFGIPLRGTHSHAFVSSFMSTDEIVDKVLKSADGKTTCDDFASLVQTWLT 837
D++SN AG+L G+P+ GT +H+F++SF+ ++ D +L A + D + V WL
Sbjct: 192 DSSSNTLAGQLRGVPVAGTLAHSFITSFLGSEVPPDPMLAPASSEGPAVDLPASVNLWLK 251
Query: 838 KI 843
+
Sbjct: 252 HV 253
>sp|O32090|PNCB_BACSU Nicotinate phosphoribosyltransferase OS=Bacillus subtilis
GN=pncB PE=3 SV=1
Length = 490
Score = 183 bits (464), Expect = 1e-045
Identities = 94/203 (46%), Positives = 134/203 (66%), Gaps = 3/203 (1%)
Frame = +1
Query: 133 LLNDLYQFTMAYAYWKAGKQNERSVFDLYFRKNPFGGEYTVFAGLDECIKFLASFKLTHQ 312
L DLYQ MA YW+ G ++++F+L+FR+ PF Y VFAGL++ I++L +FK T
Sbjct: 13 LHTDLYQINMAETYWRDGIHEKKAIFELFFRRLPFENGYAVFAGLEKAIEYLENFKFTDS 72
Query: 313 EIDYVRDSLPGSEEAFCDYLRGLDCSDVEVYAIPEGSVVFPKVPLMRVEGPVGVVQLLET 492
++ Y++D L G E F +YLRGL + +Y++ EG +VF P+MRVE P+ QL+ET
Sbjct: 73 DLSYLQDEL-GYHEDFIEYLRGLSFTG-SLYSMKEGELVFNNEPIMRVEAPLVEAQLIET 130
Query: 493 PFLNLVNFASLVATNAARHRFVAGKSKSLLEFGARRAQGPDGAISASKYCYLGGFDATSN 672
LN+VN+ +L+AT AAR + V G + LEFG RRA D A+ ++ +GGF ATSN
Sbjct: 131 ALLNIVNYQTLIATKAARIKGVIG-DEVALEFGTRRAHEMDAAMWGARAALIGGFSATSN 189
Query: 673 VAAGKLFGIPLRGTHSHAFVSSF 741
V AGK F IP+ GTH+HA V ++
Sbjct: 190 VRAGKRFNIPVSGTHAHALVQAY 212
>sp|O53770|PNCB2_MYCTU Nicotinate phosphoribosyltransferase pncB2
OS=Mycobacterium tuberculosis GN=pncB2 PE=2 SV=1
Length = 463
Score = 145 bits (364), Expect = 5e-034
Identities = 82/208 (39%), Positives = 129/208 (62%), Gaps = 4/208 (1%)
Frame = +1
Query: 124 VTPLLNDLYQFTMAYAYWKAGKQNERSVFDLYFRKNPFGGEYTVFAGLDECIKFLASFKL 303
V L DLY+ TMA AYW A + + +VF+++FRK P G Y + AGL + ++FL +F+
Sbjct: 7 VGALFTDLYEVTMAQAYW-AERMSGTAVFEIFFRKLPPGRSYIMAAGLADVVEFLEAFRF 65
Query: 304 THQEIDYVRDSLPGSEEAFCDYLRGLDCSDVEVYAIPEGSVVFPKVPLMRVEGPVGVVQL 483
Q++ Y+R S+E F +L G+ + +V+A PEG+V+FP P +++ P+ QL
Sbjct: 66 DEQDLRYLRGLGQFSDE-FLRWLAGVRFTG-DVWAAPEGTVIFPNEPAVQLIAPIIEAQL 123
Query: 484 LETPFLNLVNFASLVATNAARHRFVAGKSKSLLEFGARRAQGPDGAISASKYCYLGGFDA 663
+ET LN ++ S++A+ AAR A + + +++FGARRA G D A ++ YL G
Sbjct: 124 VETFVLNQIHLQSVLASKAAR-VVAAARGRPVVDFGARRAHGTDAACKVARTSYLAGAAG 182
Query: 664 TSNVAAGKLFGIPLRGTHSHAFVSSFMS 747
TSN+ A + +GIP GT +H+FV +F S
Sbjct: 183 TSNLLAARQYGIPTFGTMAHSFVQAFDS 210
>sp|Q10641|PNCB1_MYCTU Nicotinate phosphoribosyltransferase pncB1
OS=Mycobacterium tuberculosis GN=pncB1 PE=3 SV=2
Length = 448
Score = 104 bits (259), Expect = 8e-022
Identities = 70/208 (33%), Positives = 107/208 (51%), Gaps = 8/208 (3%)
Frame = +1
Query: 109 PTNPMVTPLLNDLYQFTMAYAYWKAGKQNERSVFDLYFRKNPFGGEYTVFAGLDECIKFL 288
P N LL D Y+ TM A + G N + F+++ R+ P G Y V AG ++ L
Sbjct: 14 PDNQDPAGLLTDKYELTMLAAALRDGSANRPTTFEVFARRLPTGRRYGVVAGTGRLLEAL 73
Query: 289 ASFKLTHQEIDYVRDSLPGSEEAFCDYLRGLDC-SDVEVYAIPEGSVVFPKVPLMRVEGP 465
F+ + + L + A YLR D++ YA EG + FP P++ V G
Sbjct: 74 PQFRFDADACELLAQFL---DPATVRYLREFRFRGDIDGYA--EGELYFPGSPVLSVRGS 128
Query: 466 VGVVQLLETPFLNLVNFASLVATNAARHRFVAGKSKSLLEFGARRAQGPDGAISASKYCY 645
LLET L++ N + +A+ AAR AG + L+E G+RR A++A++ Y
Sbjct: 129 FAECVLLETLVLSIFNHDTAIASAAARMVSAAG-GRPLIEMGSRRTH-ERAAVAAARAAY 186
Query: 646 LGGFDATSNVAAGKLFGIPLRGTHSHAF 729
+ GF A+SN+AA + +G+P GT +HAF
Sbjct: 187 IAGFAASSNLAAQRRYGVPAHGTAAHAF 214
Database: UniProt/SwissProt
Posted date: Sat Aug 07 14:36:18 2010
Number of letters in database: 182,829,261
Number of sequences in database: 518,415
Lambda K H
0.267 0.041 0.140
Gapped
Lambda K H
0.267 0.041 0.140
Matrix: blosum62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 116,323,427,680
Number of Sequences: 518415
Number of Extensions: 116323427680
Number of Successful Extensions: 743337835
Number of sequences better than 0.0: 0
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