BLASTX 7.6.2
Query= UN28596 /QuerySize=1297
(1296 letters)
Database: UniProt/SwissProt;
518,415 sequences; 182,829,261 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P42339|PI3K_ARATH Phosphatidylinositol 3-kinase VPS34 OS=Arab... 434 8e-121
sp|P42347|PI3K1_SOYBN Phosphatidylinositol 3-kinase, root isofor... 395 4e-109
sp|P42348|PI3K2_SOYBN Phosphatidylinositol 3-kinase, nodule isof... 390 2e-107
sp|Q6AZN6|PK3C3_XENLA Phosphatidylinositol 3-kinase catalytic su... 228 7e-059
sp|Q6PF93|PK3C3_MOUSE Phosphatidylinositol 3-kinase catalytic su... 222 5e-057
sp|Q8NEB9|PK3C3_HUMAN Phosphatidylinositol 3-kinase catalytic su... 221 1e-056
sp|Q5D891|PK3C3_PIG Phosphatidylinositol 3-kinase catalytic subu... 221 1e-056
sp|O88763|PK3C3_RAT Phosphatidylinositol 3-kinase catalytic subu... 220 2e-056
sp|P54676|PI3K4_DICDI Phosphatidylinositol 3-kinase VPS34-like O... 213 3e-054
sp|P50520|VPS34_SCHPO Phosphatidylinositol 3-kinase vps34 OS=Sch... 211 8e-054
sp|P22543|VPS34_YEAST Phosphatidylinositol 3-kinase VPS34 OS=Sac... 211 1e-053
>sp|P42339|PI3K_ARATH Phosphatidylinositol 3-kinase VPS34 OS=Arabidopsis
thaliana GN=At1g60490 PE=2 SV=2
Length = 814
Score = 434 bits (1115), Expect = 8e-121
Identities = 218/244 (89%), Positives = 231/244 (94%), Gaps = 1/244 (0%)
Frame = +2
Query: 2 EQSMKKLPPDVNGEDGNKLWQSLVGQTGLTAQLVSITREVRNVRGNTQKKIEKLRQLLSG 181
E+++ KLPP VNGEDG +LWQSLV QT LTAQL SITREVRNVRGNTQKKIEKLRQLL G
Sbjct: 447 EENIIKLPPGVNGEDGYQLWQSLVRQTELTAQLCSITREVRNVRGNTQKKIEKLRQLLGG 506
Query: 182 LLSELTYFEEPIRSPLTPSVLIKGIVPGESTLFKSQLNPLLLAFRTEDE-GTCKVIFKKG 358
LLSELTYFEEPIRSPLTP+VLIKGIV GES+LFKS L+PL L FRT +E G+CK+IFKKG
Sbjct: 507 LLSELTYFEEPIRSPLTPNVLIKGIVAGESSLFKSALHPLRLTFRTPEEGGSCKLIFKKG 566
Query: 359 DDLRQDQLVVQLVWLMDRLLKLENLDLCLTPYKVLATGHDEGMLEFIPSRSLAQILSEHR 538
DDLRQDQLVVQ+VWLMDRLLKLENLDLCLTPYKVLATGHDEGMLEFIPSRSLAQILSEHR
Sbjct: 567 DDLRQDQLVVQMVWLMDRLLKLENLDLCLTPYKVLATGHDEGMLEFIPSRSLAQILSEHR 626
Query: 539 SITSYLQKFHPDEHAPFGITASCLETFIKSCAGYSVITYILGIGDRHLDNLLLTDDGRLF 718
SITSYLQKFHPDEHAPFGITA+CL+TFIKSCAGYSVITYILGIGDRHLDNLLLTDDGRLF
Sbjct: 627 SITSYLQKFHPDEHAPFGITATCLDTFIKSCAGYSVITYILGIGDRHLDNLLLTDDGRLF 686
Query: 719 HVDF 730
HVDF
Sbjct: 687 HVDF 690
Score = 261 bits (666), Expect = 9e-069
Identities = 124/125 (99%), Positives = 125/125 (100%)
Frame = +3
Query: 729 FAFILGRDPKPFPPPMKLCKEMVEAMGGAESQYYTRFKSYCCEAYNILRKSSNLILNLFY 908
FAFILGRDPKPFPPPMKLCKEMVEAMGGAESQYYTRFKSYCCEAYNILRKSSNLILNLF+
Sbjct: 690 FAFILGRDPKPFPPPMKLCKEMVEAMGGAESQYYTRFKSYCCEAYNILRKSSNLILNLFH 749
Query: 909 LMAGSTIPDIASDPEKGILKLQEKFRLDMDDEACIHFFQDLINESVSALFPQMVETIHRW 1088
LMAGSTIPDIASDPEKGILKLQEKFRLDMDDEACIHFFQDLINESVSALFPQMVETIHRW
Sbjct: 750 LMAGSTIPDIASDPEKGILKLQEKFRLDMDDEACIHFFQDLINESVSALFPQMVETIHRW 809
Query: 1089 AQYWR 1103
AQYWR
Sbjct: 810 AQYWR 814
>sp|P42347|PI3K1_SOYBN Phosphatidylinositol 3-kinase, root isoform OS=Glycine
max PE=2 SV=1
Length = 814
Score = 395 bits (1014), Expect = 4e-109
Identities = 203/243 (83%), Positives = 218/243 (89%), Gaps = 1/243 (0%)
Frame = +2
Query: 5 QSMKKLPPDVNG-EDGNKLWQSLVGQTGLTAQLVSITREVRNVRGNTQKKIEKLRQLLSG 181
++M K+ VNG EDG K WQSLV QT LTAQL SITREVRNVRGNTQKKIEKLRQLLSG
Sbjct: 448 ENMMKIAAGVNGEEDGFKQWQSLVRQTELTAQLCSITREVRNVRGNTQKKIEKLRQLLSG 507
Query: 182 LLSELTYFEEPIRSPLTPSVLIKGIVPGESTLFKSQLNPLLLAFRTEDEGTCKVIFKKGD 361
LLSELTYF+EPIRSPL P VLI GIVP ES++FKS L+PL L+FRT + GTCK+IFKKGD
Sbjct: 508 LLSELTYFDEPIRSPLAPGVLIAGIVPSESSIFKSALHPLRLSFRTANGGTCKIIFKKGD 567
Query: 362 DLRQDQLVVQLVWLMDRLLKLENLDLCLTPYKVLATGHDEGMLEFIPSRSLAQILSEHRS 541
DLRQDQLVVQ+V LMDRLLKLENLDL LTPYKVLATG DEGMLEFIPSRSLAQILSE+RS
Sbjct: 568 DLRQDQLVVQMVSLMDRLLKLENLDLHLTPYKVLATGQDEGMLEFIPSRSLAQILSENRS 627
Query: 542 ITSYLQKFHPDEHAPFGITASCLETFIKSCAGYSVITYILGIGDRHLDNLLLTDDGRLFH 721
I SYLQKFHPD+H PFGITA+CLETFIKSCAGYSVITYILGIGDRHLDNLLL +DG LFH
Sbjct: 628 IISYLQKFHPDDHGPFGITATCLETFIKSCAGYSVITYILGIGDRHLDNLLLRNDGGLFH 687
Query: 722 VDF 730
VDF
Sbjct: 688 VDF 690
Score = 255 bits (649), Expect = 9e-067
Identities = 121/125 (96%), Positives = 122/125 (97%)
Frame = +3
Query: 729 FAFILGRDPKPFPPPMKLCKEMVEAMGGAESQYYTRFKSYCCEAYNILRKSSNLILNLFY 908
F FILGRDPKPFPPPMKLCKEMVEAMGGAESQYYTRFKSYCCEAYNILRKSSNLILNLFY
Sbjct: 690 FGFILGRDPKPFPPPMKLCKEMVEAMGGAESQYYTRFKSYCCEAYNILRKSSNLILNLFY 749
Query: 909 LMAGSTIPDIASDPEKGILKLQEKFRLDMDDEACIHFFQDLINESVSALFPQMVETIHRW 1088
LMAGS IPDIASDPEKGILKLQEKFRLD+DDEA IHFFQDLINESVSALFPQMVETIHRW
Sbjct: 750 LMAGSNIPDIASDPEKGILKLQEKFRLDLDDEASIHFFQDLINESVSALFPQMVETIHRW 809
Query: 1089 AQYWR 1103
AQYWR
Sbjct: 810 AQYWR 814
>sp|P42348|PI3K2_SOYBN Phosphatidylinositol 3-kinase, nodule isoform OS=Glycine
max PE=2 SV=1
Length = 812
Score = 390 bits (1000), Expect = 2e-107
Identities = 200/243 (82%), Positives = 215/243 (88%), Gaps = 1/243 (0%)
Frame = +2
Query: 5 QSMKKLPPDVNG-EDGNKLWQSLVGQTGLTAQLVSITREVRNVRGNTQKKIEKLRQLLSG 181
++M K+ VNG EDG K WQSLV QT LTAQL SITREV NVRGNTQKKIEKLRQLLSG
Sbjct: 446 ENMMKIAAGVNGEEDGFKQWQSLVRQTELTAQLCSITREVSNVRGNTQKKIEKLRQLLSG 505
Query: 182 LLSELTYFEEPIRSPLTPSVLIKGIVPGESTLFKSQLNPLLLAFRTEDEGTCKVIFKKGD 361
LLSELTYF+EPIRSPL P VLI GIVP ES++FKS L+PL L FR + GTCK+IFKKGD
Sbjct: 506 LLSELTYFDEPIRSPLAPGVLITGIVPSESSIFKSALHPLRLTFRAANGGTCKIIFKKGD 565
Query: 362 DLRQDQLVVQLVWLMDRLLKLENLDLCLTPYKVLATGHDEGMLEFIPSRSLAQILSEHRS 541
D+RQDQLVVQ+V LMDRLLKLENLDL LTPYKVLATG DEGMLEFIPSRSLAQILSE+RS
Sbjct: 566 DIRQDQLVVQMVSLMDRLLKLENLDLHLTPYKVLATGQDEGMLEFIPSRSLAQILSENRS 625
Query: 542 ITSYLQKFHPDEHAPFGITASCLETFIKSCAGYSVITYILGIGDRHLDNLLLTDDGRLFH 721
I SYLQKFHPD+H PFGITA+CLETFIKSCAGYSVITYILGIGDRHLDNLLL +DG LFH
Sbjct: 626 IISYLQKFHPDDHGPFGITATCLETFIKSCAGYSVITYILGIGDRHLDNLLLRNDGGLFH 685
Query: 722 VDF 730
VDF
Sbjct: 686 VDF 688
Score = 253 bits (644), Expect = 3e-066
Identities = 120/125 (96%), Positives = 122/125 (97%)
Frame = +3
Query: 729 FAFILGRDPKPFPPPMKLCKEMVEAMGGAESQYYTRFKSYCCEAYNILRKSSNLILNLFY 908
F FILGRDPKPFPPPMKLCKEMVEAMGGAESQYYTRFKSYCCEAY+ILRKSSNLILNLFY
Sbjct: 688 FGFILGRDPKPFPPPMKLCKEMVEAMGGAESQYYTRFKSYCCEAYHILRKSSNLILNLFY 747
Query: 909 LMAGSTIPDIASDPEKGILKLQEKFRLDMDDEACIHFFQDLINESVSALFPQMVETIHRW 1088
LMAGS IPDIASDPEKGILKLQEKFRLD+DDEA IHFFQDLINESVSALFPQMVETIHRW
Sbjct: 748 LMAGSNIPDIASDPEKGILKLQEKFRLDLDDEASIHFFQDLINESVSALFPQMVETIHRW 807
Query: 1089 AQYWR 1103
AQYWR
Sbjct: 808 AQYWR 812
>sp|Q6AZN6|PK3C3_XENLA Phosphatidylinositol 3-kinase catalytic subunit type 3
OS=Xenopus laevis GN=pik3c3 PE=2 SV=1
Length = 886
Score = 228 bits (581), Expect = 7e-059
Identities = 120/235 (51%), Positives = 165/235 (70%), Gaps = 3/235 (1%)
Frame = +2
Query: 32 VNGEDGNKLWQSLVG-QTGLTAQLVSITREVRNVRGNTQKKIEKLRQLLSGLLSELTYFE 208
+ G+ ++ +SL+ Q +LV + + V+ GN +KK E+L+ LL G ++ E
Sbjct: 528 LKGDKSVRVMRSLLATQQTFVDRLVHLMKAVQRESGNRKKKNERLQALL-GDNEKMNLSE 586
Query: 209 -EPIRSPLTPSVLIKGIVPGESTLFKSQLNPLLLAFRTEDEGTCKVIFKKGDDLRQDQLV 385
EPI PL P V I+GI+P ++TLFKS L P L F+TED G VIFK GDDLRQDQL+
Sbjct: 587 FEPIPLPLEPQVKIRGIIPEKATLFKSALMPAKLYFKTEDGGKYPVIFKNGDDLRQDQLI 646
Query: 386 VQLVWLMDRLLKLENLDLCLTPYKVLATGHDEGMLEFIPSRSLAQILSEHRSITSYLQKF 565
+Q++ LMD+LL+ ENLDL LTPYKVLAT G ++FI S +A++L+ SI ++ +K+
Sbjct: 647 LQIISLMDKLLRKENLDLKLTPYKVLATSTKHGFMQFIQSVPVAEVLATEGSIQNFFRKY 706
Query: 566 HPDEHAPFGITASCLETFIKSCAGYSVITYILGIGDRHLDNLLLTDDGRLFHVDF 730
P E P+GI+A ++T++KSCAGY VITYILG+GDRHLDNLLLT G+LFH+DF
Sbjct: 707 SPSEKGPYGISAEVMDTYVKSCAGYCVITYILGVGDRHLDNLLLTKTGKLFHIDF 761
Score = 159 bits (401), Expect = 5e-038
Identities = 74/125 (59%), Positives = 95/125 (76%)
Frame = +3
Query: 729 FAFILGRDPKPFPPPMKLCKEMVEAMGGAESQYYTRFKSYCCEAYNILRKSSNLILNLFY 908
F +ILGRDPKP PPPMKL KEMVE MGG +S+ Y F+ C A+ LR+ SNLILNLF
Sbjct: 761 FGYILGRDPKPLPPPMKLNKEMVEGMGGTQSEQYQAFRKQCYTAFLHLRRYSNLILNLFS 820
Query: 909 LMAGSTIPDIASDPEKGILKLQEKFRLDMDDEACIHFFQDLINESVSALFPQMVETIHRW 1088
LM + IPDIA +P+K + K+Q+KFRLD+ DE +H+ Q LI++SV+ALF +VE IH++
Sbjct: 821 LMVDANIPDIALEPDKTVKKVQDKFRLDLSDEEAVHYMQTLIDDSVNALFAAVVEQIHKF 880
Query: 1089 AQYWR 1103
AQYWR
Sbjct: 881 AQYWR 885
>sp|Q6PF93|PK3C3_MOUSE Phosphatidylinositol 3-kinase catalytic subunit type 3
OS=Mus musculus GN=Pik3c3 PE=1 SV=1
Length = 887
Score = 222 bits (565), Expect = 5e-057
Identities = 117/234 (50%), Positives = 158/234 (67%), Gaps = 1/234 (0%)
Frame = +2
Query: 32 VNGEDGNKLWQSLV-GQTGLTAQLVSITREVRNVRGNTQKKIEKLRQLLSGLLSELTYFE 208
+ G+ ++ +SL+ Q +LV + + V+ GN +KK E+L+ LL
Sbjct: 529 LKGDKSVRVMRSLLAAQQTFVDRLVHLMKAVQRESGNRKKKNERLQALLGDNEKMNLSDV 588
Query: 209 EPIRSPLTPSVLIKGIVPGESTLFKSQLNPLLLAFRTEDEGTCKVIFKKGDDLRQDQLVV 388
E I PL P V I+GI+P +TLFKS L P L F+TED G VIFK GDDLRQDQL++
Sbjct: 589 ELIPLPLEPQVKIRGIIPETATLFKSALMPAQLFFKTEDGGKYPVIFKHGDDLRQDQLIL 648
Query: 389 QLVWLMDRLLKLENLDLCLTPYKVLATGHDEGMLEFIPSRSLAQILSEHRSITSYLQKFH 568
Q++ LMD+LL+ ENLDL LTPYKVLAT G ++FI S +A++L SI ++ +K+
Sbjct: 649 QIISLMDKLLRKENLDLKLTPYKVLATSTKHGFMQFIQSVPVAEVLDTEGSIQNFFRKYA 708
Query: 569 PDEHAPFGITASCLETFIKSCAGYSVITYILGIGDRHLDNLLLTDDGRLFHVDF 730
P E P+GI+A ++T++KSCAGY VITYILG+GDRHLDNLLLT G+LFH+DF
Sbjct: 709 PSETGPYGISAEVMDTYVKSCAGYCVITYILGVGDRHLDNLLLTKTGKLFHIDF 762
Score = 160 bits (404), Expect = 2e-038
Identities = 75/125 (60%), Positives = 94/125 (75%)
Frame = +3
Query: 729 FAFILGRDPKPFPPPMKLCKEMVEAMGGAESQYYTRFKSYCCEAYNILRKSSNLILNLFY 908
F +ILGRDPKP PPPMKL KEMVE MGG +S+ Y F+ C A+ LR+ SNLILNLF
Sbjct: 762 FGYILGRDPKPLPPPMKLNKEMVEGMGGTQSEQYQEFRKQCYTAFLHLRRYSNLILNLFS 821
Query: 909 LMAGSTIPDIASDPEKGILKLQEKFRLDMDDEACIHFFQDLINESVSALFPQMVETIHRW 1088
LM + IPDIA +P+K + K+Q+KFRLD+ DE +H+ Q LI+ESV ALF +VE IH++
Sbjct: 822 LMVDANIPDIALEPDKTVKKVQDKFRLDLSDEEAVHYMQSLIDESVHALFAAVVEQIHKF 881
Query: 1089 AQYWR 1103
AQYWR
Sbjct: 882 AQYWR 886
>sp|Q8NEB9|PK3C3_HUMAN Phosphatidylinositol 3-kinase catalytic subunit type 3
OS=Homo sapiens GN=PIK3C3 PE=1 SV=1
Length = 887
Score = 221 bits (562), Expect = 1e-056
Identities = 117/234 (50%), Positives = 158/234 (67%), Gaps = 1/234 (0%)
Frame = +2
Query: 32 VNGEDGNKLWQSLV-GQTGLTAQLVSITREVRNVRGNTQKKIEKLRQLLSGLLSELTYFE 208
+ G+ ++ +SL+ Q +LV + + V+ GN +KK E+L+ LL
Sbjct: 529 LKGDKSVRVMRSLLAAQQTFVDRLVHLMKAVQRESGNRKKKNERLQALLGDNEKMNLSDV 588
Query: 209 EPIRSPLTPSVLIKGIVPGESTLFKSQLNPLLLAFRTEDEGTCKVIFKKGDDLRQDQLVV 388
E I PL P V I+GI+P +TLFKS L P L F+TED G VIFK GDDLRQDQL++
Sbjct: 589 ELIPLPLEPQVKIRGIIPETATLFKSALMPAQLFFKTEDGGKYPVIFKHGDDLRQDQLIL 648
Query: 389 QLVWLMDRLLKLENLDLCLTPYKVLATGHDEGMLEFIPSRSLAQILSEHRSITSYLQKFH 568
Q++ LMD+LL+ ENLDL LTPYKVLAT G ++FI S +A++L SI ++ +K+
Sbjct: 649 QIISLMDKLLRKENLDLKLTPYKVLATSTKHGFMQFIQSVPVAEVLDTEGSIQNFFRKYA 708
Query: 569 PDEHAPFGITASCLETFIKSCAGYSVITYILGIGDRHLDNLLLTDDGRLFHVDF 730
P E+ P GI+A ++T++KSCAGY VITYILG+GDRHLDNLLLT G+LFH+DF
Sbjct: 709 PSENGPNGISAEVMDTYVKSCAGYCVITYILGVGDRHLDNLLLTKTGKLFHIDF 762
Score = 160 bits (404), Expect = 2e-038
Identities = 75/125 (60%), Positives = 94/125 (75%)
Frame = +3
Query: 729 FAFILGRDPKPFPPPMKLCKEMVEAMGGAESQYYTRFKSYCCEAYNILRKSSNLILNLFY 908
F +ILGRDPKP PPPMKL KEMVE MGG +S+ Y F+ C A+ LR+ SNLILNLF
Sbjct: 762 FGYILGRDPKPLPPPMKLNKEMVEGMGGTQSEQYQEFRKQCYTAFLHLRRYSNLILNLFS 821
Query: 909 LMAGSTIPDIASDPEKGILKLQEKFRLDMDDEACIHFFQDLINESVSALFPQMVETIHRW 1088
LM + IPDIA +P+K + K+Q+KFRLD+ DE +H+ Q LI+ESV ALF +VE IH++
Sbjct: 822 LMVDANIPDIALEPDKTVKKVQDKFRLDLSDEEAVHYMQSLIDESVHALFAAVVEQIHKF 881
Query: 1089 AQYWR 1103
AQYWR
Sbjct: 882 AQYWR 886
>sp|Q5D891|PK3C3_PIG Phosphatidylinositol 3-kinase catalytic subunit type 3
OS=Sus scrofa GN=PIK3C3 PE=2 SV=1
Length = 887
Score = 221 bits (562), Expect = 1e-056
Identities = 117/234 (50%), Positives = 158/234 (67%), Gaps = 1/234 (0%)
Frame = +2
Query: 32 VNGEDGNKLWQSLV-GQTGLTAQLVSITREVRNVRGNTQKKIEKLRQLLSGLLSELTYFE 208
+ G+ ++ +SL+ Q +LV + + V+ GN +KK E+L+ LL
Sbjct: 529 LKGDKSVRVMRSLLAAQQTFVDRLVHLMKAVQRESGNRKKKNERLQALLGDNEKMNLSDV 588
Query: 209 EPIRSPLTPSVLIKGIVPGESTLFKSQLNPLLLAFRTEDEGTCKVIFKKGDDLRQDQLVV 388
E I PL P V I+GI+P +TLFKS L P L F+TED G VIFK GDDLRQDQL++
Sbjct: 589 ELIPLPLEPQVKIRGIIPETATLFKSALMPAQLFFKTEDGGKYPVIFKHGDDLRQDQLIL 648
Query: 389 QLVWLMDRLLKLENLDLCLTPYKVLATGHDEGMLEFIPSRSLAQILSEHRSITSYLQKFH 568
Q++ LMD+LL+ ENLDL LTPYKVLAT G ++FI S +A++L SI ++ +K+
Sbjct: 649 QIISLMDKLLRKENLDLKLTPYKVLATSTKHGFMQFIQSVPVAEVLDTEGSIQNFFRKYA 708
Query: 569 PDEHAPFGITASCLETFIKSCAGYSVITYILGIGDRHLDNLLLTDDGRLFHVDF 730
P E+ P GI+A ++T++KSCAGY VITYILG+GDRHLDNLLLT G+LFH+DF
Sbjct: 709 PSENGPNGISAEVMDTYVKSCAGYCVITYILGVGDRHLDNLLLTKTGKLFHIDF 762
Score = 160 bits (404), Expect = 2e-038
Identities = 75/125 (60%), Positives = 94/125 (75%)
Frame = +3
Query: 729 FAFILGRDPKPFPPPMKLCKEMVEAMGGAESQYYTRFKSYCCEAYNILRKSSNLILNLFY 908
F +ILGRDPKP PPPMKL KEMVE MGG +S+ Y F+ C A+ LR+ SNLILNLF
Sbjct: 762 FGYILGRDPKPLPPPMKLNKEMVEGMGGTQSEQYQEFRKQCYTAFLHLRRYSNLILNLFS 821
Query: 909 LMAGSTIPDIASDPEKGILKLQEKFRLDMDDEACIHFFQDLINESVSALFPQMVETIHRW 1088
LM + IPDIA +P+K + K+Q+KFRLD+ DE +H+ Q LI+ESV ALF +VE IH++
Sbjct: 822 LMVDANIPDIALEPDKTVKKVQDKFRLDLSDEEAVHYMQSLIDESVHALFAAVVEQIHKF 881
Query: 1089 AQYWR 1103
AQYWR
Sbjct: 882 AQYWR 886
>sp|O88763|PK3C3_RAT Phosphatidylinositol 3-kinase catalytic subunit type 3
OS=Rattus norvegicus GN=Pik3c3 PE=2 SV=1
Length = 887
Score = 220 bits (559), Expect = 2e-056
Identities = 117/234 (50%), Positives = 157/234 (67%), Gaps = 1/234 (0%)
Frame = +2
Query: 32 VNGEDGNKLWQSLV-GQTGLTAQLVSITREVRNVRGNTQKKIEKLRQLLSGLLSELTYFE 208
+ G+ ++ +SL+ Q +LV + + V+ GN +KK E+L+ LL
Sbjct: 529 LKGDKSVRVMRSLLAAQQTFVDRLVHLMKAVQRESGNRKKKNERLQALLGDNEKMNLSDV 588
Query: 209 EPIRSPLTPSVLIKGIVPGESTLFKSQLNPLLLAFRTEDEGTCKVIFKKGDDLRQDQLVV 388
E I PL P V I+GI+P +TLFKS L P L F+TED G VIFK GDDLRQDQL++
Sbjct: 589 ELIPLPLEPQVKIRGIIPETATLFKSALMPAQLFFKTEDGGKYPVIFKHGDDLRQDQLIL 648
Query: 389 QLVWLMDRLLKLENLDLCLTPYKVLATGHDEGMLEFIPSRSLAQILSEHRSITSYLQKFH 568
Q++ LMD+LL+ ENLDL LTPYKVLAT G ++FI S +A++L SI ++ +K+
Sbjct: 649 QIISLMDKLLRKENLDLKLTPYKVLATSTKHGFMQFIQSVPVAEVLDTEGSIQNFFRKYA 708
Query: 569 PDEHAPFGITASCLETFIKSCAGYSVITYILGIGDRHLDNLLLTDDGRLFHVDF 730
P E P GI+A ++T++KSCAGY VITYILG+GDRHLDNLLLT G+LFH+DF
Sbjct: 709 PSETGPNGISAEVMDTYVKSCAGYCVITYILGVGDRHLDNLLLTKTGKLFHIDF 762
Score = 160 bits (404), Expect = 2e-038
Identities = 75/125 (60%), Positives = 94/125 (75%)
Frame = +3
Query: 729 FAFILGRDPKPFPPPMKLCKEMVEAMGGAESQYYTRFKSYCCEAYNILRKSSNLILNLFY 908
F +ILGRDPKP PPPMKL KEMVE MGG +S+ Y F+ C A+ LR+ SNLILNLF
Sbjct: 762 FGYILGRDPKPLPPPMKLNKEMVEGMGGTQSEQYQEFRKQCYTAFLHLRRYSNLILNLFS 821
Query: 909 LMAGSTIPDIASDPEKGILKLQEKFRLDMDDEACIHFFQDLINESVSALFPQMVETIHRW 1088
LM + IPDIA +P+K + K+Q+KFRLD+ DE +H+ Q LI+ESV ALF +VE IH++
Sbjct: 822 LMVDANIPDIALEPDKTVKKVQDKFRLDLSDEEAVHYMQSLIDESVHALFAAVVEQIHKF 881
Query: 1089 AQYWR 1103
AQYWR
Sbjct: 882 AQYWR 886
>sp|P54676|PI3K4_DICDI Phosphatidylinositol 3-kinase VPS34-like OS=Dictyostelium
discoideum GN=pikE PE=3 SV=2
Length = 816
Score = 213 bits (541), Expect = 3e-054
Identities = 115/226 (50%), Positives = 159/226 (70%), Gaps = 4/226 (1%)
Frame = +2
Query: 62 QSLVGQTGLTAQLVSITREVRNVRGNTQKKIEKLRQLLS-GLLSELTYFEEPIRSPLTPS 238
Q + Q ++L ++ E++ + +KKIEKLR +L+ G +L+ F +PIR P+ P
Sbjct: 467 QRVNAQNKFISRLSLLSVELKAMNITREKKIEKLRIMLAEGEYKDLSDF-QPIRLPVNPD 525
Query: 239 VLIKGIVPGESTLFKSQLNPLLLAFRTEDEGTCKVIFKKGDDLRQDQLVVQLVWLMDRLL 418
+ I GIVP +S ++KS +PL L RT VIFK GDDLRQDQL++QL+ LMDRLL
Sbjct: 526 IEIIGIVPEKSNIYKSAKSPLGLKLRTTKGEEYGVIFKTGDDLRQDQLIIQLISLMDRLL 585
Query: 419 KLENLDLCLTPYKVLATGHDEGMLEFI-PSRSLAQILSEH-RSITSYLQKFHPDEHAPFG 592
K ENLDL LTPYKVLAT ++G++E + PS ++A +LS++ I + + +PD +P+G
Sbjct: 586 KKENLDLKLTPYKVLATAEEDGIVEMVNPSEAMASVLSKYDGDILKFFKTHNPDADSPYG 645
Query: 593 ITASCLETFIKSCAGYSVITYILGIGDRHLDNLLLTDDGRLFHVDF 730
I ++TF+KSCAGY VITYILGIGDRHLDNLLLT +G+LFH+DF
Sbjct: 646 IAPEVMDTFVKSCAGYCVITYILGIGDRHLDNLLLTPNGKLFHIDF 691
Score = 162 bits (408), Expect = 8e-039
Identities = 73/125 (58%), Positives = 95/125 (76%)
Frame = +3
Query: 729 FAFILGRDPKPFPPPMKLCKEMVEAMGGAESQYYTRFKSYCCEAYNILRKSSNLILNLFY 908
F +ILG+DPK PPPMKLCKEMV MGG S++Y +FK CCEAYNILRKSS+LILNLF
Sbjct: 691 FGYILGKDPKILPPPMKLCKEMVLGMGGENSKHYEKFKQLCCEAYNILRKSSHLILNLFA 750
Query: 909 LMAGSTIPDIASDPEKGILKLQEKFRLDMDDEACIHFFQDLINESVSALFPQMVETIHRW 1088
LM ++IP I+ D EK ILK+QEK +L++ D+ + L+N+SV+ALFP ++E H+W
Sbjct: 751 LMVDASIPSISDDKEKSILKVQEKLQLELTDQEASNSLLQLLNDSVTALFPVIIEMAHKW 810
Query: 1089 AQYWR 1103
QYW+
Sbjct: 811 LQYWK 815
>sp|P50520|VPS34_SCHPO Phosphatidylinositol 3-kinase vps34
OS=Schizosaccharomyces pombe GN=vps34 PE=2 SV=2
Length = 801
Score = 211 bits (537), Expect = 8e-054
Identities = 111/233 (47%), Positives = 156/233 (66%), Gaps = 5/233 (2%)
Frame = +2
Query: 44 DGNKLWQSLVGQTGLTAQLVSITREVRNVRGNTQKKIEKLRQLLSGLLSELTYFEEPIRS 223
+G + ++L Q +L+ I++ V++ RG KKIE L+ LL L F +
Sbjct: 445 EGRLIRETLSAQAKFVEKLLRISKSVQSFRGTRLKKIEYLKVLLEDHKYHLLDF-HALPL 503
Query: 224 PLTPSVLIKGIVPGESTLFKSQLNPLLLAFRTEDEGTCKVIFKKGDDLRQDQLVVQLVWL 403
PL PSV I GI+P T+FKS + PL L F+ +D +IFK GDDLRQDQLV+Q++ L
Sbjct: 504 PLDPSVNIVGIIPDACTVFKSTMQPLRLLFKCQDGSKYPIIFKNGDDLRQDQLVIQILTL 563
Query: 404 MDRLLKLENLDLCLTPYKVLATGHDEGMLEFIPSRSLAQILSE-HRSITSYLQKFHPDE- 577
MD+LLK E LDL L PY++LATG G ++F+PS++LA IL+E H S+ +YL++ +PD+
Sbjct: 564 MDKLLKKEKLDLHLKPYRILATGPTHGAVQFVPSKTLATILAEYHGSVLAYLRENNPDDG 623
Query: 578 --HAPFGITASCLETFIKSCAGYSVITYILGIGDRHLDNLLLTDDGRLFHVDF 730
A +GI ++ +++SCAGY VITY+LG+GDRHLDNLL+T DG FH DF
Sbjct: 624 LNSANYGIDPVAMDNYVRSCAGYCVITYLLGVGDRHLDNLLITKDGHFFHADF 676
>sp|P22543|VPS34_YEAST Phosphatidylinositol 3-kinase VPS34 OS=Saccharomyces
cerevisiae GN=VPS34 PE=1 SV=1
Length = 875
Score = 211 bits (535), Expect = 1e-053
Identities = 111/216 (51%), Positives = 146/216 (67%), Gaps = 5/216 (2%)
Frame = +2
Query: 95 QLVSITRE----VRNVRGNTQKKIEKLRQLLSGLLSELTYFEEPIRSPLTPSVLIKGIVP 262
+L+++ RE ++ ++ T KK+E L LL + L PI PL P VLI + P
Sbjct: 536 RLINVLRECCETIKRLKDTTAKKMELLVHLLETKVRPLVKV-RPIALPLDPDVLICDVCP 594
Query: 263 GESTLFKSQLNPLLLAFRTEDEGTCKVIFKKGDDLRQDQLVVQLVWLMDRLLKLENLDLC 442
S +FKS L+PL + F+T ++FK GDDLRQDQLVVQ++ LM+ LLK EN+DL
Sbjct: 595 ETSKVFKSSLSPLKITFKTTLNQPYHLMFKVGDDLRQDQLVVQIISLMNELLKNENVDLK 654
Query: 443 LTPYKVLATGHDEGMLEFIPSRSLAQILSEHRSITSYLQKFHPDEHAPFGITASCLETFI 622
LTPYK+LATG EG +EFIP+ +LA ILS++ I YL+ +PDE+A G+ L+ F+
Sbjct: 655 LTPYKILATGPQEGAIEFIPNDTLASILSKYHGILGYLKLHYPDENATLGVQGWVLDNFV 714
Query: 623 KSCAGYSVITYILGIGDRHLDNLLLTDDGRLFHVDF 730
KSCAGY VITYILG+GDRHLDNLL+T DG FH DF
Sbjct: 715 KSCAGYCVITYILGVGDRHLDNLLVTPDGHFFHADF 750
Database: UniProt/SwissProt
Posted date: Sat Aug 07 14:36:18 2010
Number of letters in database: 182,829,261
Number of sequences in database: 518,415
Lambda K H
0.267 0.041 0.140
Gapped
Lambda K H
0.267 0.041 0.140
Matrix: blosum62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 119,210,902,748
Number of Sequences: 518415
Number of Extensions: 119210902748
Number of Successful Extensions: 754584153
Number of sequences better than 0.0: 0
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