BLASTX 7.6.2
Query= UN32535 /QuerySize=1238
(1237 letters)
Database: UniProt/SwissProt;
518,415 sequences; 182,829,261 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|O35075|DSCR3_MOUSE Down syndrome critical region protein 3 ho... 185 8e-046
sp|O14972|DSCR3_HUMAN Down syndrome critical region protein 3 OS... 184 1e-045
sp|Q5RF33|DSCR3_PONAB Down syndrome critical region protein 3 ho... 183 4e-045
sp|Q54DI8|DSCR3_DICDI Down syndrome critical region protein 3 ho... 156 5e-037
>sp|O35075|DSCR3_MOUSE Down syndrome critical region protein 3 homolog OS=Mus
musculus GN=Dscr3 PE=2 SV=1
Length = 297
Score = 185 bits (468), Expect = 8e-046
Identities = 102/250 (40%), Positives = 150/250 (60%), Gaps = 10/250 (4%)
Frame = -3
Query: 1175 MEGKIVIKSPNSISHQAIRLSVNGSVNLQVRGGSAGVIESFYGVIKPIQILKKTIEVRSS 996
+ G +VI S +S+ HQ + L++ G+VNLQ+ S GV E+FY +KPIQI+ TI+V
Sbjct: 22 LSGVVVISSKDSVQHQGVSLTMEGTVNLQLSAKSVGVFEAFYNSVKPIQIINSTIDVLKP 81
Query: 995 GRIPPGTTEIPFSVNLREPAESIAEKFYETFHGTNINIQYLLTADIPRGYLHKPLSATVE 816
G+IP G TE+PF L + YET+HG +NIQY L D+ R L K L+ T E
Sbjct: 82 GKIPSGKTEVPFEFPLLVKGSKV---LYETYHGVFVNIQYTLRCDMRRSLLAKDLTKTCE 138
Query: 815 FIIDSGRVDLPER-LLPPEMVIFYITQDTQRHPLLPDIKTGGFRVTGKL-ATQCSLHDPL 642
FI+ S P++ L P V F IT +T ++ + F + G L +T C++ PL
Sbjct: 139 FIVHSA----PQKGKLTPSPVDFTITPETLQN-VKERASLPKFFIRGHLNSTNCAITQPL 193
Query: 641 SGELTVEASSVPITSIDIHLLRVESIIVGERIVTETSLIQSTQIADGDVCRKMTLPIYVL 462
+GEL VE S I SI++ L+RVE+ E + + IQ+ QIADGD+CR +++P+Y++
Sbjct: 194 TGELVVEHSDAAIRSIELQLVRVETCGCAEGYARDATEIQNIQIADGDICRNLSVPLYMV 253
Query: 461 LPRLLMCPSI 432
PRL CP++
Sbjct: 254 FPRLFTCPTL 263
>sp|O14972|DSCR3_HUMAN Down syndrome critical region protein 3 OS=Homo sapiens
GN=DSCR3 PE=1 SV=1
Length = 297
Score = 184 bits (466), Expect = 1e-045
Identities = 105/254 (41%), Positives = 149/254 (58%), Gaps = 18/254 (7%)
Frame = -3
Query: 1175 MEGKIVIKSPNSISHQAIRLSVNGSVNLQVRGGSAGVIESFYGVIKPIQILKKTIEVRSS 996
+ G +VI S +S+ HQ + L++ G+VNLQ+ S GV E+FY +KPIQI+ TIE+
Sbjct: 22 LSGVVVISSKDSVQHQGVSLTMEGTVNLQLSAKSVGVFEAFYNSVKPIQIINSTIEMVKP 81
Query: 995 GRIPPGTTEIPFSVNLREPAESIAEKFYETFHGTNINIQYLLTADIPRGYLHKPLSATVE 816
G+ P G TEIPF L + YET+HG +NIQY L D+ R L K L+ T E
Sbjct: 82 GKFPSGKTEIPFEFPLHLKGNKV---LYETYHGVFVNIQYTLRCDMKRSLLAKDLTKTCE 138
Query: 815 FIIDSGRVDLPER-LLPPEMVIFYIT----QDTQRHPLLPDIKTGGFRVTGKL-ATQCSL 654
FI+ S P++ P V F IT Q+ + LLP F + G L +T C +
Sbjct: 139 FIVHSA----PQKGKFTPSPVDFTITPETLQNVKERALLPK-----FLLRGHLNSTNCVI 189
Query: 653 HDPLSGELTVEASSVPITSIDIHLLRVESIIVGERIVTETSLIQSTQIADGDVCRKMTLP 474
PL+GEL VE+S I S+++ L+RVE+ E + + IQ+ QIADGDVCR +++P
Sbjct: 190 TQPLTGELVVESSEAAIRSVELQLVRVETCGCAEGYARDATEIQNIQIADGDVCRGLSVP 249
Query: 473 IYVLLPRLLMCPSI 432
IY++ PRL CP++
Sbjct: 250 IYMVFPRLFTCPTL 263
>sp|Q5RF33|DSCR3_PONAB Down syndrome critical region protein 3 homolog OS=Pongo
abelii GN=DSCR3 PE=2 SV=1
Length = 297
Score = 183 bits (462), Expect = 4e-045
Identities = 104/254 (40%), Positives = 148/254 (58%), Gaps = 18/254 (7%)
Frame = -3
Query: 1175 MEGKIVIKSPNSISHQAIRLSVNGSVNLQVRGGSAGVIESFYGVIKPIQILKKTIEVRSS 996
+ G +VI S +S+ HQ + L++ G+VNLQ+ S GV E+FY +KPIQI+ IE+
Sbjct: 22 LSGVVVISSKDSVQHQGVSLTMEGTVNLQLSAKSVGVFEAFYNSVKPIQIINSNIEMVKP 81
Query: 995 GRIPPGTTEIPFSVNLREPAESIAEKFYETFHGTNINIQYLLTADIPRGYLHKPLSATVE 816
G+ P G TEIPF L + YET+HG +NIQY L D+ R L K L+ T E
Sbjct: 82 GKFPSGKTEIPFEFPLHVKGNKV---LYETYHGVFVNIQYTLRCDMKRSLLAKDLTKTCE 138
Query: 815 FIIDSGRVDLPER-LLPPEMVIFYIT----QDTQRHPLLPDIKTGGFRVTGKL-ATQCSL 654
FI+ S P++ P V F IT Q+ + LLP F + G L +T C +
Sbjct: 139 FIVHSA----PQKGKFSPSPVHFTITPETLQNARERALLPK-----FLLRGHLNSTNCVI 189
Query: 653 HDPLSGELTVEASSVPITSIDIHLLRVESIIVGERIVTETSLIQSTQIADGDVCRKMTLP 474
PL+GEL VE+S I S+++ L+RVE+ E + + IQ+ QIADGDVCR +++P
Sbjct: 190 TQPLTGELVVESSEAAIRSVELQLVRVETCGCAEGYARDATEIQNIQIADGDVCRGLSVP 249
Query: 473 IYVLLPRLLMCPSI 432
IY++ PRL CP++
Sbjct: 250 IYMVFPRLFTCPTL 263
>sp|Q54DI8|DSCR3_DICDI Down syndrome critical region protein 3 homolog
OS=Dictyostelium discoideum GN=DDB_G0292212 PE=3 SV=1
Length = 304
Score = 156 bits (392), Expect = 5e-037
Identities = 87/254 (34%), Positives = 146/254 (57%), Gaps = 12/254 (4%)
Frame = -3
Query: 1175 MEGKIVIKSPNSISHQAIRLSVNGSVNLQVRGGSAGVIESFYGVIKPIQILKKTIEV-RS 999
+ G +VI S + +SH + + V G+V LQ+ S G+ E+FY +KPI ++ TI V
Sbjct: 22 VSGNVVINSKDDMSHSGVTIVVEGTVQLQLSSKSVGLFEAFYNSLKPITLMHYTISVTNG 81
Query: 998 SGRIPPGTTEIPFSVNLREPAESIAEKFYETFHGTNINIQYLLTADIPRGYLHKPLSATV 819
G+ G TE+PF L EP + ++ Y+T+HG +NIQY + D+ RG L K LS T+
Sbjct: 82 GGKFQAGITELPFEFTL-EPLPN--QQLYDTYHGVFVNIQYSIKCDVKRGILSKDLSKTI 138
Query: 818 EFIID--SGRVDLPERLLPPEMVIFYITQDTQ---RHPLLPDIKTGGFRVTGKLATQ-CS 657
EFI++ S ++ + P ++ F IT D+ + D+ T F+++G L + C+
Sbjct: 139 EFIVEVPSQNKEVLMKSTPESLITFNITPDSLVNFKKISKADVPT--FKISGGLVSAICN 196
Query: 656 LHDPLSGELTVEASSVPITSIDIHLLRVESIIVGERIVTETSLIQSTQIADGDVCRKMTL 477
+++ G + +E++ I S+++ L+RVE+ + E + IQ+ QIADGD+ R +
Sbjct: 197 INEAFQGHMIIESADTVIKSVELQLVRVETCGCADGYAREVTEIQNIQIADGDIWRNFKI 256
Query: 476 PIYVLLPRLLMCPS 435
P+Y++ PRL C S
Sbjct: 257 PLYMVFPRLFTCIS 270
Database: UniProt/SwissProt
Posted date: Sat Aug 07 14:36:18 2010
Number of letters in database: 182,829,261
Number of sequences in database: 518,415
Lambda K H
0.267 0.041 0.140
Gapped
Lambda K H
0.267 0.041 0.140
Matrix: blosum62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 129,408,327,353
Number of Sequences: 518415
Number of Extensions: 129408327353
Number of Successful Extensions: 804511681
Number of sequences better than 0.0: 0
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