BLASTX 7.6.2
Query= UN33240 /QuerySize=958
(957 letters)
Database: UniProt/SwissProt;
518,415 sequences; 182,829,261 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q6GMF8|RHDF1_DANRE Rhomboid family member 1 OS=Danio rerio GN... 93 3e-018
sp|Q6PIX5|RHDF1_MOUSE Rhomboid family member 1 OS=Mus musculus G... 91 8e-018
sp|Q499S9|RHDF1_RAT Rhomboid family member 1 OS=Rattus norvegicu... 91 1e-017
sp|A7YWH9|RHDF1_BOVIN Rhomboid family member 1 OS=Bos taurus GN=... 89 4e-017
sp|B0VX73|RHDF1_CALJA Rhomboid family member 1 OS=Callithrix jac... 89 4e-017
sp|B1MT31|RHDF1_CALMO Rhomboid family member 1 OS=Callicebus mol... 89 4e-017
sp|Q96CC6|RHDF1_HUMAN Rhomboid family member 1 OS=Homo sapiens G... 89 4e-017
sp|A9L8T6|RHDF1_PAPAN Rhomboid family member 1 OS=Papio anubis G... 89 4e-017
sp|A0JPA1|RHDF2_XENTR Rhomboid family member 2 OS=Xenopus tropic... 88 7e-017
sp|Q00M95|RHDF2_CANFA Rhomboid family member 2 OS=Canis familiar... 82 6e-015
sp|Q6PJF5|RHDF2_HUMAN Rhomboid family member 2 OS=Homo sapiens G... 82 6e-015
sp|Q80WQ6|RHDF2_MOUSE Rhomboid family member 2 OS=Mus musculus G... 80 2e-014
sp|Q695T8|RHBL4_TOXGO Rhomboid-like protease 4 OS=Toxoplasma gon... 72 4e-012
sp|Q6GV23|RHBL5_TOXGO Rhomboid-like protease 5 OS=Toxoplasma gon... 67 1e-010
sp|P54493|GLUP_BACSU Rhomboid protease gluP OS=Bacillus subtilis... 66 4e-010
sp|Q6IUY1|RHBL3_TOXGO Rhomboid-like protease 3 OS=Toxoplasma gon... 61 1e-008
sp|Q695U0|RHBL1_TOXGO Rhomboid-like protease 1 OS=Toxoplasma gon... 55 8e-007
sp|P58872|RHBL3_HUMAN Rhomboid-related protein 3 OS=Homo sapiens... 51 9e-006
sp|P58873|RHBL3_MOUSE Rhomboid-related protein 3 OS=Mus musculus... 51 9e-006
>sp|Q6GMF8|RHDF1_DANRE Rhomboid family member 1 OS=Danio rerio GN=rhbdf1 PE=2
SV=1
Length = 857
Score = 93 bits (229), Expect = 3e-018
Identities = 47/119 (39%), Positives = 71/119 (59%), Gaps = 5/119 (4%)
Frame = +2
Query: 38 LRDLVSLSLEQEFGFVRIGLLYMISGFGGSLLSSLFNREGISVGASGALFGLLGAMLSEL 217
LRDL L+ G++RI ++Y++SG G+L S++F VG +G+ FG+L + EL
Sbjct: 682 LRDLEKLA-----GWLRISIIYILSGITGNLASAIFLPYRAEVGPAGSQFGILACLFVEL 736
Query: 218 LTNWTIYANKFAALLTLIFIIAINLAVGILPHVDNFAHLGGFTSGFLLGFVFLIRPQYG 394
+ +W I A + A L+ ++ A G+LP +DNFAH+ GF SGF L F FL +G
Sbjct: 737 IQSWQILAQPWRAFTKLLCVVLFLFAFGLLPWIDNFAHISGFISGFFLSFAFLPYISFG 795
>sp|Q6PIX5|RHDF1_MOUSE Rhomboid family member 1 OS=Mus musculus GN=Rhbdf1 PE=1
SV=2
Length = 856
Score = 91 bits (225), Expect = 8e-018
Identities = 47/122 (38%), Positives = 70/122 (57%), Gaps = 5/122 (4%)
Frame = +2
Query: 38 LRDLVSLSLEQEFGFVRIGLLYMISGFGGSLLSSLFNREGISVGASGALFGLLGAMLSEL 217
LRDL L+ G+ RI ++Y++SG G+L S++F VG +G+ FG+L + EL
Sbjct: 681 LRDLEKLA-----GWHRIAIIYLLSGITGNLASAIFLPYRAEVGPAGSQFGILACLFVEL 735
Query: 218 LTNWTIYANKFAALLTLIFIIAINLAVGILPHVDNFAHLGGFTSGFLLGFVFLIRPQYGY 397
+W I A + A L+ ++ A G+LP +DNFAH+ GF SG L F FL +G
Sbjct: 736 FQSWQILARPWRAFFKLLAVVLFLFAFGLLPWIDNFAHISGFVSGLFLSFAFLPYISFGK 795
Query: 398 FN 403
F+
Sbjct: 796 FD 797
>sp|Q499S9|RHDF1_RAT Rhomboid family member 1 OS=Rattus norvegicus GN=Rhbdf1
PE=2 SV=1
Length = 856
Score = 91 bits (224), Expect = 1e-017
Identities = 47/122 (38%), Positives = 70/122 (57%), Gaps = 5/122 (4%)
Frame = +2
Query: 38 LRDLVSLSLEQEFGFVRIGLLYMISGFGGSLLSSLFNREGISVGASGALFGLLGAMLSEL 217
LRDL L+ G+ RI ++Y++SG G+L S++F VG +G+ FG+L + EL
Sbjct: 681 LRDLEKLA-----GWHRIAIIYLLSGVTGNLASAIFLPYRAEVGPAGSQFGILACLFVEL 735
Query: 218 LTNWTIYANKFAALLTLIFIIAINLAVGILPHVDNFAHLGGFTSGFLLGFVFLIRPQYGY 397
+W I A + A L+ ++ A G+LP +DNFAH+ GF SG L F FL +G
Sbjct: 736 FQSWQILARPWRAFFKLLAVVLFLFAFGLLPWIDNFAHISGFVSGLFLSFAFLPYISFGK 795
Query: 398 FN 403
F+
Sbjct: 796 FD 797
>sp|A7YWH9|RHDF1_BOVIN Rhomboid family member 1 OS=Bos taurus GN=RHBDF1 PE=2
SV=1
Length = 856
Score = 89 bits (219), Expect = 4e-017
Identities = 46/122 (37%), Positives = 69/122 (56%), Gaps = 5/122 (4%)
Frame = +2
Query: 38 LRDLVSLSLEQEFGFVRIGLLYMISGFGGSLLSSLFNREGISVGASGALFGLLGAMLSEL 217
LRDL L+ G+ RI ++Y++SG G+L S++F VG +G+ FG+L + EL
Sbjct: 681 LRDLEKLA-----GWHRIAIIYLLSGVTGNLASAIFLPYRAEVGPAGSQFGILACLFVEL 735
Query: 218 LTNWTIYANKFAALLTLIFIIAINLAVGILPHVDNFAHLGGFTSGFLLGFVFLIRPQYGY 397
+W I A + A L+ ++ G+LP +DNFAH+ GF SG L F FL +G
Sbjct: 736 FQSWQILARPWRAFFKLLAVVLFLFTFGLLPWIDNFAHISGFISGLFLSFAFLPYISFGK 795
Query: 398 FN 403
F+
Sbjct: 796 FD 797
>sp|B0VX73|RHDF1_CALJA Rhomboid family member 1 OS=Callithrix jacchus GN=RHBDF1
PE=3 SV=1
Length = 855
Score = 89 bits (219), Expect = 4e-017
Identities = 45/127 (35%), Positives = 70/127 (55%)
Frame = +2
Query: 23 LLGFTLRDLVSLSLEQEFGFVRIGLLYMISGFGGSLLSSLFNREGISVGASGALFGLLGA 202
L+ + V LE+ G+ RI ++Y++SG G+L S++F VG +G+ FG+L
Sbjct: 670 LVSICFQMTVLRDLEKLAGWHRIAIIYLLSGVTGNLASAIFLPYRAEVGPAGSQFGILAC 729
Query: 203 MLSELLTNWTIYANKFAALLTLIFIIAINLAVGILPHVDNFAHLGGFTSGFLLGFVFLIR 382
+ EL +W I A + A L+ ++ G+LP +DNFAH+ GF SG L F FL
Sbjct: 730 LFVELFQSWQILARPWRAFFKLLAVVLFLFTFGLLPWIDNFAHISGFISGLFLSFAFLPY 789
Query: 383 PQYGYFN 403
+G F+
Sbjct: 790 ISFGKFD 796
>sp|B1MT31|RHDF1_CALMO Rhomboid family member 1 OS=Callicebus moloch GN=RHBDF1
PE=3 SV=1
Length = 855
Score = 89 bits (219), Expect = 4e-017
Identities = 45/127 (35%), Positives = 70/127 (55%)
Frame = +2
Query: 23 LLGFTLRDLVSLSLEQEFGFVRIGLLYMISGFGGSLLSSLFNREGISVGASGALFGLLGA 202
L+ + V LE+ G+ RI ++Y++SG G+L S++F VG +G+ FG+L
Sbjct: 670 LVSICFQMTVLRDLEKLAGWHRIAIIYLLSGVTGNLASAIFLPYRAEVGPAGSQFGILAC 729
Query: 203 MLSELLTNWTIYANKFAALLTLIFIIAINLAVGILPHVDNFAHLGGFTSGFLLGFVFLIR 382
+ EL +W I A + A L+ ++ G+LP +DNFAH+ GF SG L F FL
Sbjct: 730 LFVELFQSWQILARPWRAFFKLLAVVLFLFTFGLLPWIDNFAHISGFISGLFLSFAFLPY 789
Query: 383 PQYGYFN 403
+G F+
Sbjct: 790 ISFGKFD 796
>sp|Q96CC6|RHDF1_HUMAN Rhomboid family member 1 OS=Homo sapiens GN=RHBDF1 PE=1
SV=2
Length = 855
Score = 89 bits (219), Expect = 4e-017
Identities = 45/127 (35%), Positives = 70/127 (55%)
Frame = +2
Query: 23 LLGFTLRDLVSLSLEQEFGFVRIGLLYMISGFGGSLLSSLFNREGISVGASGALFGLLGA 202
L+ + V LE+ G+ RI ++Y++SG G+L S++F VG +G+ FG+L
Sbjct: 670 LVSICFQMTVLRDLEKLAGWHRIAIIYLLSGVTGNLASAIFLPYRAEVGPAGSQFGILAC 729
Query: 203 MLSELLTNWTIYANKFAALLTLIFIIAINLAVGILPHVDNFAHLGGFTSGFLLGFVFLIR 382
+ EL +W I A + A L+ ++ G+LP +DNFAH+ GF SG L F FL
Sbjct: 730 LFVELFQSWQILARPWRAFFKLLAVVLFLFTFGLLPWIDNFAHISGFISGLFLSFAFLPY 789
Query: 383 PQYGYFN 403
+G F+
Sbjct: 790 ISFGKFD 796
>sp|A9L8T6|RHDF1_PAPAN Rhomboid family member 1 OS=Papio anubis GN=RHBDF1 PE=3
SV=1
Length = 855
Score = 89 bits (219), Expect = 4e-017
Identities = 45/127 (35%), Positives = 70/127 (55%)
Frame = +2
Query: 23 LLGFTLRDLVSLSLEQEFGFVRIGLLYMISGFGGSLLSSLFNREGISVGASGALFGLLGA 202
L+ + V LE+ G+ RI ++Y++SG G+L S++F VG +G+ FG+L
Sbjct: 670 LVSICFQMTVLRDLEKLAGWHRIAIIYLLSGVTGNLASAIFLPYRAEVGPAGSQFGILAC 729
Query: 203 MLSELLTNWTIYANKFAALLTLIFIIAINLAVGILPHVDNFAHLGGFTSGFLLGFVFLIR 382
+ EL +W I A + A L+ ++ G+LP +DNFAH+ GF SG L F FL
Sbjct: 730 LFVELFQSWQILARPWRAFFKLLAVVLFLFTFGLLPWIDNFAHISGFISGLFLSFAFLPY 789
Query: 383 PQYGYFN 403
+G F+
Sbjct: 790 ISFGKFD 796
>sp|A0JPA1|RHDF2_XENTR Rhomboid family member 2 OS=Xenopus tropicalis GN=rhbdf2
PE=2 SV=1
Length = 826
Score = 88 bits (217), Expect = 7e-017
Identities = 48/113 (42%), Positives = 67/113 (59%), Gaps = 5/113 (4%)
Frame = +2
Query: 38 LRDLVSLSLEQEFGFVRIGLLYMISGFGGSLLSSLFNREGISVGASGALFGLLGAMLSEL 217
LRDL L+ G++RI ++Y++SG G+L S+LF VG +G+ FGLL + EL
Sbjct: 651 LRDLEKLA-----GWLRISIIYILSGITGNLASALFLPYRAEVGPAGSQFGLLACLFVEL 705
Query: 218 LTNWTIYANKFAALLTLIFIIAINLAVGILPHVDNFAHLGGFTSGFLLGFVFL 376
+W I A + A L L+ I+ G+LP +DN AH+ GF SG LL F FL
Sbjct: 706 FQSWQILAKPWKAFLKLLGIVLFLFLFGLLPWIDNIAHIFGFLSGLLLSFSFL 758
>sp|Q00M95|RHDF2_CANFA Rhomboid family member 2 OS=Canis familiaris GN=RHBDF2
PE=2 SV=1
Length = 827
Score = 82 bits (200), Expect = 6e-015
Identities = 44/113 (38%), Positives = 64/113 (56%), Gaps = 5/113 (4%)
Frame = +2
Query: 38 LRDLVSLSLEQEFGFVRIGLLYMISGFGGSLLSSLFNREGISVGASGALFGLLGAMLSEL 217
LRDL L+ G+ RI +++++SG G+L S++F VG +G+ FGLL + EL
Sbjct: 652 LRDLEKLA-----GWHRIAIIFILSGITGNLASAIFLPYRAEVGPAGSQFGLLACLFVEL 706
Query: 218 LTNWTIYANKFAALLTLIFIIAINLAVGILPHVDNFAHLGGFTSGFLLGFVFL 376
+W + + A L L I+ G+LP +DN AH+ GF SG LL F FL
Sbjct: 707 FQSWQLLERPWKAFLNLSAIVLFLFICGLLPWIDNIAHIFGFLSGLLLAFAFL 759
>sp|Q6PJF5|RHDF2_HUMAN Rhomboid family member 2 OS=Homo sapiens GN=RHBDF2 PE=1
SV=2
Length = 856
Score = 82 bits (200), Expect = 6e-015
Identities = 44/113 (38%), Positives = 64/113 (56%), Gaps = 5/113 (4%)
Frame = +2
Query: 38 LRDLVSLSLEQEFGFVRIGLLYMISGFGGSLLSSLFNREGISVGASGALFGLLGAMLSEL 217
LRDL L+ G+ RI +++++SG G+L S++F VG +G+ FGLL + EL
Sbjct: 681 LRDLEKLA-----GWHRIAIIFILSGITGNLASAIFLPYRAEVGPAGSQFGLLACLFVEL 735
Query: 218 LTNWTIYANKFAALLTLIFIIAINLAVGILPHVDNFAHLGGFTSGFLLGFVFL 376
+W + + A L L I+ G+LP +DN AH+ GF SG LL F FL
Sbjct: 736 FQSWPLLERPWKAFLNLSAIVLFLFICGLLPWIDNIAHIFGFLSGLLLAFAFL 788
>sp|Q80WQ6|RHDF2_MOUSE Rhomboid family member 2 OS=Mus musculus GN=Rhbdf2 PE=1
SV=1
Length = 827
Score = 80 bits (196), Expect = 2e-014
Identities = 43/113 (38%), Positives = 63/113 (55%), Gaps = 5/113 (4%)
Frame = +2
Query: 38 LRDLVSLSLEQEFGFVRIGLLYMISGFGGSLLSSLFNREGISVGASGALFGLLGAMLSEL 217
LRDL L+ G+ RI +++++SG G+L S++F VG +G+ FGLL + EL
Sbjct: 652 LRDLEKLA-----GWHRISIIFILSGITGNLASAIFLPYRAEVGPAGSQFGLLACLFVEL 706
Query: 218 LTNWTIYANKFAALLTLIFIIAINLAVGILPHVDNFAHLGGFTSGFLLGFVFL 376
+W + + A L I+ G+LP +DN AH+ GF SG LL F FL
Sbjct: 707 FQSWQLLERPWKAFFNLSAIVLFLFICGLLPWIDNIAHIFGFLSGMLLAFAFL 759
>sp|Q695T8|RHBL4_TOXGO Rhomboid-like protease 4 OS=Toxoplasma gondii GN=ROM4
PE=2 SV=1
Length = 641
Score = 72 bits (176), Expect = 4e-012
Identities = 34/102 (33%), Positives = 60/102 (58%), Gaps = 1/102 (0%)
Frame = +2
Query: 62 LEQEFGFVRIGLLYMISGFGGSLLSSLFNREGISVGASGALFGLLGAMLSELLTNWTIYA 241
+E ++GF+R LL+ + G G+LLS++ + I+VG+SG+++ LLGA++ + W
Sbjct: 372 IEPDWGFLRTTLLFFLGGISGNLLSAVADPCSITVGSSGSMYALLGALIPYCVEYWKSIP 431
Query: 242 NKFAALLTLIFIIAINLAVGILPHVDNFAHLGGFTSGFLLGF 367
+L + ++ I + G+ DN+AH+GG G L GF
Sbjct: 432 RP-GCILVFMIVVIIGILTGMAGFTDNYAHMGGALGGILWGF 472
>sp|Q6GV23|RHBL5_TOXGO Rhomboid-like protease 5 OS=Toxoplasma gondii GN=ROM5
PE=1 SV=1
Length = 841
Score = 67 bits (163), Expect = 1e-010
Identities = 40/105 (38%), Positives = 59/105 (56%), Gaps = 4/105 (3%)
Frame = +2
Query: 62 LEQEFGFVRIGLLYMISGFGGSLLSSLFNREGISVGASGALFGLLGAMLSELLTNWTIYA 241
LE +GF+R L+++ G GSLLS++ N ++VG+SGA +GLLGA++ + W A
Sbjct: 494 LEPAWGFLRTLSLWIVGGVSGSLLSAVANPCTVTVGSSGAFYGLLGALVPFSIEYWDHIA 553
Query: 242 NK---FAALLTLIFIIAINLAVGILPHVDNFAHLGGFTSGFLLGF 367
+ + L+ + VG+ VDN AHLGG G L GF
Sbjct: 554 SPAWFLFCVSVLVMVAQFGNMVGV-QGVDNNAHLGGLIGGLLFGF 597
>sp|P54493|GLUP_BACSU Rhomboid protease gluP OS=Bacillus subtilis GN=gluP PE=1
SV=2
Length = 507
Score = 66 bits (159), Expect = 4e-010
Identities = 44/121 (36%), Positives = 66/121 (54%), Gaps = 5/121 (4%)
Frame = +2
Query: 50 VSLSLEQEFGFVRIGLLYMISGFGGSLLSSLFNREGISVGASGALFGLLGAMLSELLTNW 229
V ++E+ +G R L+Y+ +G GS+ S +F+ S GASGA+FG LGA+L L+N
Sbjct: 248 VGTAVERMYGSGRFLLIYLAAGITGSIASFVFSPYP-SAGASGAIFGCLGALLYVALSNR 306
Query: 230 TIYANKFAALLTLIFIIAINLAVGI-LPHVDNFAHLGGFTSGFLLGFVFLIRPQYGYFNQ 406
++ +I II INL G + ++DN H+GG GF L P+ G F +
Sbjct: 307 KMFLRTIGT--NIIVIIIINLGFGFAVSNIDNSGHIGGLIGGFFAA-AALGLPKAGAFGK 363
Query: 407 R 409
R
Sbjct: 364 R 364
>sp|Q6IUY1|RHBL3_TOXGO Rhomboid-like protease 3 OS=Toxoplasma gondii GN=ROM3
PE=2 SV=1
Length = 263
Score = 61 bits (146), Expect = 1e-008
Identities = 37/106 (34%), Positives = 59/106 (55%), Gaps = 2/106 (1%)
Frame = +2
Query: 50 VSLSLEQEFGFVRIGLLYMISGFGGSLLSSLFNREGISVGASGALFGLLGAMLSELLTNW 229
+SL LE+ +G + + Y +S G+LLS L +SVGAS A FG++G M +E+ W
Sbjct: 109 ISLRLEERYGTKKFLVTYFLSAIVGNLLSMLMQPWALSVGASTAGFGIIGGMAAEVSVVW 168
Query: 230 TIYANKFAALLTL-IFIIAINL-AVGILPHVDNFAHLGGFTSGFLL 361
+ + + ++ I I+A+ + + VD F HLGGF +G L
Sbjct: 169 CKLSEELKRIYSMDICILAVLIYFLSFGRTVDTFGHLGGFLAGVAL 214
>sp|Q695U0|RHBL1_TOXGO Rhomboid-like protease 1 OS=Toxoplasma gondii GN=ROM1
PE=2 SV=1
Length = 293
Score = 55 bits (130), Expect = 8e-007
Identities = 37/122 (30%), Positives = 63/122 (51%), Gaps = 6/122 (4%)
Frame = +2
Query: 20 FLLGFTLRDLVSLSLEQEFGFVRIGLLYMISGFGGSLLS-SLFNREGISVGASGALFGLL 196
F + F LR + ++E+ +G ++ LY S G+LLS + F + VGAS A FGL+
Sbjct: 127 FNVFFQLR--MGFTIERRYGLLKFTGLYFASAIYGNLLSATAFFCNSLKVGASTAGFGLI 184
Query: 197 GAMLSELLTNWTIYANKFAALLTLI-FIIAINLAVGIL--PHVDNFAHLGGFTSGFLLGF 367
G + E+ W ++ L ++ F++ + L + L +D HLGG GF +G
Sbjct: 185 GIQICEMALTWHRMRHRDRMLTNMVSFVLLMVLLMFTLNGGSIDQMGHLGGLLCGFSIGM 244
Query: 368 VF 373
++
Sbjct: 245 LY 246
>sp|P58872|RHBL3_HUMAN Rhomboid-related protein 3 OS=Homo sapiens GN=RHBDL3 PE=2
SV=1
Length = 404
Score = 51 bits (121), Expect = 9e-006
Identities = 29/92 (31%), Positives = 49/92 (53%)
Frame = +2
Query: 26 LGFTLRDLVSLSLEQEFGFVRIGLLYMISGFGGSLLSSLFNREGISVGASGALFGLLGAM 205
L L+ LV + LE G RIGL+Y+ GSL S+ + VG+SG ++ L+ A
Sbjct: 229 LNVVLQLLVGVPLEMVHGATRIGLVYVAGVVAGSLAVSVADMTAPVVGSSGGVYALVSAH 288
Query: 206 LSELLTNWTIYANKFAALLTLIFIIAINLAVG 301
L+ ++ NW+ +F L + +I +++ G
Sbjct: 289 LANIVMNWSGMKCQFKLLRMAVALICMSMEFG 320
>sp|P58873|RHBL3_MOUSE Rhomboid-related protein 3 OS=Mus musculus GN=Rhbdl3 PE=2
SV=1
Length = 404
Score = 51 bits (121), Expect = 9e-006
Identities = 29/92 (31%), Positives = 49/92 (53%)
Frame = +2
Query: 26 LGFTLRDLVSLSLEQEFGFVRIGLLYMISGFGGSLLSSLFNREGISVGASGALFGLLGAM 205
L L+ LV + LE G RIGL+Y+ GSL S+ + VG+SG ++ L+ A
Sbjct: 229 LNVALQLLVGVPLEMVHGATRIGLVYVAGVVAGSLAVSVADMTAPVVGSSGGVYALVSAH 288
Query: 206 LSELLTNWTIYANKFAALLTLIFIIAINLAVG 301
L+ ++ NW+ +F L + +I +++ G
Sbjct: 289 LANIVMNWSGMKCQFKLLRMAVALICMSMEFG 320
Database: UniProt/SwissProt
Posted date: Sat Aug 07 14:36:18 2010
Number of letters in database: 182,829,261
Number of sequences in database: 518,415
Lambda K H
0.267 0.041 0.140
Gapped
Lambda K H
0.267 0.041 0.140
Matrix: blosum62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 132,248,888,565
Number of Sequences: 518415
Number of Extensions: 132248888565
Number of Successful Extensions: 812634680
Number of sequences better than 0.0: 0
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