BLASTX 7.6.2
Query= UN33811 /QuerySize=1139
(1138 letters)
Database: UniProt/SwissProt;
518,415 sequences; 182,829,261 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q8BMG8|MFTC_MOUSE Mitochondrial folate transporter/carrier OS... 223 3e-057
sp|Q9H2D1|MFTC_HUMAN Mitochondrial folate transporter/carrier OS... 216 3e-055
sp|Q95J75|MFTC_MACFA Mitochondrial folate transporter/carrier OS... 216 3e-055
sp|Q54QN2|MCFM_DICDI Mitochondrial substrate carrier family prot... 150 2e-035
sp|P38127|RIM2_YEAST Mitochondrial carrier protein RIM2 OS=Sacch... 148 1e-034
sp|Q9P6L7|YKQ9_SCHPO Uncharacterized mitochondrial carrier C688.... 141 2e-032
sp|Q76P23|PM34_DICDI Mitochondrial substrate carrier family prot... 140 2e-032
sp|O43808|PM34_HUMAN Peroxisomal membrane protein PMP34 OS=Homo ... 124 1e-027
sp|P39953|YEA6_YEAST Probable mitochondrial carrier YEL006W OS=S... 124 1e-027
sp|O70579|PM34_MOUSE Peroxisomal membrane protein PMP34 OS=Mus m... 120 3e-026
sp|Q54FU9|MCFW_DICDI Mitochondrial substrate carrier family prot... 117 1e-025
sp|Q4X022|TPC1_ASPFU Mitochondrial thiamine pyrophosphate carrie... 115 7e-025
sp|A1DI57|TPC1_NEOFI Mitochondrial thiamine pyrophosphate carrie... 111 1e-023
sp|A4RF23|TPC1_MAGGR Mitochondrial thiamine pyrophosphate carrie... 108 1e-022
sp|Q54BM3|MCFG_DICDI Mitochondrial substrate carrier family prot... 107 1e-022
sp|B0G159|MCFC_DICDI Mitochondrial substrate carrier family prot... 98 1e-019
sp|A7ER02|TPC1_SCLS1 Mitochondrial thiamine pyrophosphate carrie... 80 2e-014
sp|O94502|YBT5_SCHPO Uncharacterized mitochondrial carrier C12D1... 80 2e-014
sp|Q1E7P0|TPC1_COCIM Mitochondrial thiamine pyrophosphate carrie... 63 3e-009
sp|Q9UTD6|YID3_SCHPO Uncharacterized mitochondrial carrier C227.... 52 7e-006
>sp|Q8BMG8|MFTC_MOUSE Mitochondrial folate transporter/carrier OS=Mus musculus
GN=Slc25a32 PE=2 SV=1
Length = 316
Score = 223 bits (566), Expect = 3e-057
Identities = 136/301 (45%), Positives = 175/301 (58%), Gaps = 20/301 (6%)
Frame = -3
Query: 1019 WENATAGAVAGFATVAAMHPLDVVRTRFQVNDGRGLSALPTYKNTAHALFTIARLEGLRG 840
+EN AG G + A+HPLD+V+ RF V+D GL P YK H L TI +++GLR
Sbjct: 23 YENLVAGVSGGVLSNLALHPLDLVKIRFAVSD--GLEVRPKYKGILHCLATIWKVDGLR- 79
Query: 839 GLYAGFFPAVIGSTLSWSLYFFFYGRAKQRYGRGRDDDKLTPPLHLASAAEAGALVCFCT 660
GLY G P V G+ LSW LYFFFY K GR ++L P +L SAAEAGA+ T
Sbjct: 80 GLYQGVTPNVWGAGLSWGLYFFFYNAIKSYKTEGR-AEQLEPLEYLVSAAEAGAMTLCIT 138
Query: 659 NPIWLVKTRLQLQTPLHQTP---PYSGLLDAFRTIIKEEGPRALYKGILPALLLVSHGAI 489
NP+W+ KTRL LQ +P Y G+ DA I K EG R LYKG +P L SHGA+
Sbjct: 139 NPLWVTKTRLMLQYGGVASPSQRQYKGMFDALVKIYKYEGVRGLYKGFVPGLFGTSHGAL 198
Query: 488 QFTAYEELRKLIVDFKDKRRNSESTSDNLLNSADYAALGGSSKVAAVLLTYPFQVIRARL 309
QF AYE L+ ++ + L++A+Y ++ SK+ AV TYP+QV+RARL
Sbjct: 199 QFMAYELLK------LKYNKHINRLPEAQLSTAEYISVAALSKIFAVAATYPYQVVRARL 252
Query: 308 Q-QRPSTNGVPRYIDSLHVIRETARFEGVRGFYRGLTANLLKNVPASSITFIVYENVLKL 132
Q Q S GV VI +T R EG+ GFY+G+ NL++ PA ITF+VYENV
Sbjct: 253 QDQHVSYGGV------TDVITKTWRKEGIGGFYKGIAPNLIRVTPACCITFVVYENVSHF 306
Query: 131 L 129
L
Sbjct: 307 L 307
>sp|Q9H2D1|MFTC_HUMAN Mitochondrial folate transporter/carrier OS=Homo sapiens
GN=SLC25A32 PE=1 SV=2
Length = 315
Score = 216 bits (549), Expect = 3e-055
Identities = 130/300 (43%), Positives = 169/300 (56%), Gaps = 18/300 (6%)
Frame = -3
Query: 1019 WENATAGAVAGFATVAAMHPLDVVRTRFQVNDGRGLSALPTYKNTAHALFTIARLEGLRG 840
+EN AG G + A+HPLD+V+ RF V+D GL P Y H L TI +L+GLR
Sbjct: 23 YENLIAGVSGGVLSNLALHPLDLVKIRFAVSD--GLELRPKYNGILHCLTTIWKLDGLR- 79
Query: 839 GLYAGFFPAVIGSTLSWSLYFFFYGRAKQRYGRGRDDDKLTPPLHLASAAEAGALVCFCT 660
GLY G P + G+ LSW LYFFFY K GR ++L +L SAAEAGA+ T
Sbjct: 80 GLYQGVTPNIWGAGLSWGLYFFFYNAIKSYKTEGR-AERLEATEYLVSAAEAGAMTLCIT 138
Query: 659 NPIWLVKTRLQLQTPLHQTPP---YSGLLDAFRTIIKEEGPRALYKGILPALLLVSHGAI 489
NP+W+ KTRL LQ P Y G+ D I K EG R LYKG +P L SHGA+
Sbjct: 139 NPLWVTKTRLMLQYDAVVNSPHRQYKGMFDTLVKIYKYEGVRGLYKGFVPGLFGTSHGAL 198
Query: 488 QFTAYEELRKLIVDFKDKRRNSESTSDNLLNSADYAALGGSSKVAAVLLTYPFQVIRARL 309
QF AYE L+ ++ + L++ +Y ++ SK+ AV TYP+QV+RARL
Sbjct: 199 QFMAYELLK------LKYNQHINRLPEAQLSTVEYISVAALSKIFAVAATYPYQVVRARL 252
Query: 308 QQRPSTNGVPRYIDSLHVIRETARFEGVRGFYRGLTANLLKNVPASSITFIVYENVLKLL 129
Q + Y + VI +T R EGV GFY+G+ NL++ PA ITF+VYENV L
Sbjct: 253 QDQHMF-----YSGVIDVITKTWRKEGVGGFYKGIAPNLIRVTPACCITFVVYENVSHFL 307
>sp|Q95J75|MFTC_MACFA Mitochondrial folate transporter/carrier OS=Macaca
fascicularis GN=SLC25A32 PE=2 SV=1
Length = 315
Score = 216 bits (549), Expect = 3e-055
Identities = 130/300 (43%), Positives = 169/300 (56%), Gaps = 18/300 (6%)
Frame = -3
Query: 1019 WENATAGAVAGFATVAAMHPLDVVRTRFQVNDGRGLSALPTYKNTAHALFTIARLEGLRG 840
+EN AG G + A+HPLD+V+ RF V+D GL P Y H L TI +L+GLR
Sbjct: 23 YENLVAGVSGGVLSNLALHPLDLVKIRFAVSD--GLELRPKYNGILHCLTTIWKLDGLR- 79
Query: 839 GLYAGFFPAVIGSTLSWSLYFFFYGRAKQRYGRGRDDDKLTPPLHLASAAEAGALVCFCT 660
GLY G P V G+ LSW LYFFFY K GR ++L +L SAAEAGA+ T
Sbjct: 80 GLYQGVTPNVWGAGLSWGLYFFFYNAIKSYKTEGR-AERLEATEYLVSAAEAGAMTLCIT 138
Query: 659 NPIWLVKTRLQLQTPLHQTPP---YSGLLDAFRTIIKEEGPRALYKGILPALLLVSHGAI 489
NP+W+ KTRL LQ P Y G+ D I K EG R LYKG +P L SHGA+
Sbjct: 139 NPLWVTKTRLMLQYDAVINSPHRQYKGMFDTLVKIYKYEGVRGLYKGFVPGLFGTSHGAL 198
Query: 488 QFTAYEELRKLIVDFKDKRRNSESTSDNLLNSADYAALGGSSKVAAVLLTYPFQVIRARL 309
QF AYE L+ ++ + L++ +Y ++ SK+ AV TYP+QV+RARL
Sbjct: 199 QFMAYELLK------LKYNQHINRLPEAQLSTVEYISVAALSKIFAVAATYPYQVVRARL 252
Query: 308 QQRPSTNGVPRYIDSLHVIRETARFEGVRGFYRGLTANLLKNVPASSITFIVYENVLKLL 129
Q + Y + VI +T R EG+ GFY+G+ NL++ PA ITF+VYENV L
Sbjct: 253 QDQHMF-----YSGVIDVITKTWRKEGIGGFYKGIAPNLIRVTPACCITFVVYENVSHFL 307
>sp|Q54QN2|MCFM_DICDI Mitochondrial substrate carrier family protein M
OS=Dictyostelium discoideum GN=mcfM PE=3 SV=1
Length = 306
Score = 150 bits (378), Expect = 2e-035
Identities = 97/303 (32%), Positives = 149/303 (49%), Gaps = 28/303 (9%)
Frame = -3
Query: 1007 TAGAVAGFATVAAMHPLDVVRTRFQ---------VNDGRGLSALPTYKNTAHALFTIARL 855
T+ + A + P D ++ R Q +N + + + T KN + +
Sbjct: 12 TSALLGSTVATAFLQPFDFLKIRLQGSGFASGGDLNKFKRVGVIDTCKN-------VLKN 64
Query: 854 EGLRGGLYAGFFPAVIGSTLSWSLYFFFYGRAKQRYGRGRDDDKLTPPLHLASAAEAGAL 675
EG++ + G P ++ S ++W Y FY K + +L H A A A
Sbjct: 65 EGIK-QFWRGSSPTIVASGIAWGTYMHFYEAYKNILKSKYNVTQLNTFDHFICAVGASAT 123
Query: 674 VCFCTNPIWLVKTRLQLQTPLHQTPPYSGLLDAFRTIIKEEGPRALYKGILPALLLVSHG 495
F TNPI+L+KTR+QLQTP Y+G+ D + +K EG + LYKG++P+L L HG
Sbjct: 124 QVFITNPIFLIKTRMQLQTP-GSANYYTGIFDGIKKTVKVEGFKGLYKGVIPSLWLTFHG 182
Query: 494 AIQFTAYEELRKLIVDFKDKRRNSESTSDNLLNSADYAALGGSSKVAAVLLTYPFQVIRA 315
IQ ++YE ++ K +S LN+++ SK A + YPFQV++
Sbjct: 183 GIQMSSYEHIKFYFSSNSGKSLDS-------LNASEIFIASSISKFLASTILYPFQVVKT 235
Query: 314 RLQQR---PSTNGVPRYIDSLHVIRETARFEGVRGFYRGLTANLLKNVPASSITFIVYEN 144
RLQ P+ N V Y + VI + + EG+ GFYRGL N LK +P +SIT ++YE
Sbjct: 236 RLQDERNIPNQNNVRVYNGTKDVIFKILKNEGIIGFYRGLVPNTLKVIPNTSITLLLYEE 295
Query: 143 VLK 135
+ K
Sbjct: 296 IKK 298
>sp|P38127|RIM2_YEAST Mitochondrial carrier protein RIM2 OS=Saccharomyces
cerevisiae GN=RIM2 PE=2 SV=1
Length = 377
Score = 148 bits (371), Expect = 1e-034
Identities = 88/265 (33%), Positives = 142/265 (53%), Gaps = 13/265 (4%)
Frame = -3
Query: 896 YKNTAHALFTIARLEGLRGGLYAGFFPAVIGSTLSWSLYFFFYGRAKQRYGRGRDDDKLT 717
+K T + + + EG R L+ G P ++G + S+ FF YG K Y + ++ + T
Sbjct: 116 FKETLGIIGNVYKQEGFR-SLFKGLGPNLVGVIPARSINFFTYGTTKDMYAKAFNNGQET 174
Query: 716 PPLHLASAAEAGALVCFCTNPIWLVKTRLQL----QTPLHQTPPYSGLLDAFRTIIKEEG 549
P +HL +AA AG TNPIWL+KTR+QL +T + Q Y D +++I+ EG
Sbjct: 175 PMIHLMAAATAGWATATATNPIWLIKTRVQLDKAGKTSVRQ---YKNSWDCLKSVIRNEG 231
Query: 548 PRALYKGILPALLLVSHGAIQFTAYEELRKLIVD-----FKDKRRNSESTSDNLLNSADY 384
LYKG+ + L G +Q+ YE++++LI + F + ++STS+ +
Sbjct: 232 FTGLYKGLSASYLGSVEGILQWLLYEQMKRLIKERSIEKFGYQAEGTKSTSEKVKEWCQR 291
Query: 383 AALGGSSKVAAVLLTYPFQVIRARLQQRPSTNGVPRYIDSLHVIRETARFEGVRGFYRGL 204
+ G +K A + TYP +V+R RL+Q P NG +Y + + + EG+ Y GL
Sbjct: 292 SGSAGLAKFVASIATYPHEVVRTRLRQTPKENGKRKYTGLVQSFKVIIKEEGLFSMYSGL 351
Query: 203 TANLLKNVPASSITFIVYENVLKLL 129
T +L++ VP S I F +E V++LL
Sbjct: 352 TPHLMRTVPNSIIMFGTWEIVIRLL 376
>sp|Q9P6L7|YKQ9_SCHPO Uncharacterized mitochondrial carrier C688.09
OS=Schizosaccharomyces pombe GN=SPAC688.09 PE=2 SV=1
Length = 361
Score = 141 bits (353), Expect = 2e-032
Identities = 92/283 (32%), Positives = 140/283 (49%), Gaps = 8/283 (2%)
Frame = -3
Query: 956 DVVRTRFQVNDGRGLSALPT----YKNTAHALFTIARLEGLRGGLYAGFFPAVIGSTLSW 789
D + RF + S L + +T L + EG R L+ G P +IG+ +
Sbjct: 79 DFYKDRFLKQTAKSKSPLTAAYRHFMDTCIILKNVKVHEGTR-ALFRGLGPNLIGTIPAR 137
Query: 788 SLYFFFYGRAKQRYGRGRDDDKLTPPLHLASAAEAGALVCFCTNPIWLVKTRLQLQTPLH 609
S+ FF YG K+ ++ + +HL +AA AG + TNPIWLVKTRLQL
Sbjct: 138 SINFFSYGNGKRILADLFNNGQENSQIHLMAAAIAGVITSAATNPIWLVKTRLQLDKKSG 197
Query: 608 QTPPYSGLLDAFRTIIKEEGPRALYKGILPALLLVSHGAIQFTAYEELRKLIVDFKDKRR 429
Q Y +D I+ EG R LYKG+ +LL V +Q+ YE+ + + + +R+
Sbjct: 198 QAAQYRSSIDCIIKTIRLEGFRGLYKGLSASLLGVGESTLQWVLYEKFKHAVAIRQLRRK 257
Query: 428 N---SESTSDNLLNSADYAALGGSSKVAAVLLTYPFQVIRARLQQRPSTNGVPRYIDSLH 258
E+ D +L+ G +K A + YP +V+R RL+Q PS NG P+Y +
Sbjct: 258 ELGIQETIYDKVLDWGGKLGGAGIAKFMAAGIAYPHEVVRTRLRQSPSINGTPKYTGLIQ 317
Query: 257 VIRETARFEGVRGFYRGLTANLLKNVPASSITFIVYENVLKLL 129
+ +G+ G Y GLTA+LL+ VP + I F YE ++ +
Sbjct: 318 CFKLVWMEQGIVGLYGGLTAHLLRVVPNACILFGSYEVIMHFI 360
>sp|Q76P23|PM34_DICDI Mitochondrial substrate carrier family protein Q
OS=Dictyostelium discoideum GN=mcfQ PE=2 SV=1
Length = 329
Score = 140 bits (352), Expect = 2e-032
Identities = 98/304 (32%), Positives = 161/304 (52%), Gaps = 30/304 (9%)
Frame = -3
Query: 1013 NATAGAVAGFATVAAMHPLDVVRTRFQVNDGR-------GLSALPTYKNTAHALFTIARL 855
+A +G VAG A +A +P V TR QV + ++ +P YKN+ A I +
Sbjct: 23 HAISGGVAGMAAIALTYPFSTVSTRLQVQQKKQQQGQQSEITTVP-YKNSIDAFKRIIKE 81
Query: 854 EGLRGGLYAGFFPAVIGSTLSWSLYFFFYGRAKQRYGRGRDDDKLTPPLHLASAAEAGAL 675
E R LY+G A+IG S +Y+++Y K + ++ +L +LA AA AG
Sbjct: 82 ENWR-TLYSGLKSALIGIGASSFVYYYWYTLLKSISLKLKNKQELGTIENLAIAALAGCA 140
Query: 674 VCFCTNPIWLVKTRLQLQTPLHQTPPYSGLLDAFRTIIKEEGPRALYKGILPALLLVSHG 495
T PIW+V TRLQ+ + G++ F+ IIK EG LYKG++PAL+LVS+
Sbjct: 141 NVLTTLPIWVVNTRLQINSD-------KGIVGQFKYIIKNEGFGGLYKGLIPALILVSNP 193
Query: 494 AIQFTAYEELRKLIVDFKDKRRNSESTSDNLLNSADYAALGGSSKVAAVLLTYPFQVIRA 315
++QF +YE+LR L RR S T L + LG +K+ A ++TYP+ ++++
Sbjct: 194 SVQFVSYEKLRAL------WRRQSGRTK---LGGLEVFILGAIAKLIAGIVTYPYLLVKS 244
Query: 314 RLQQRPSTNGVP-----RYIDSLHVIRETARFEGVRGFYRGLTANLLKNVPASSITFIVY 150
RLQ + P +Y +L I + + +G GF++G+ + +++ V ++ F+V
Sbjct: 245 RLQSQSGNASNPESQQQQYKGTLDAIGKIFKSDGFLGFFKGMPSKMVQTVIGAAFMFLVK 304
Query: 149 ENVL 138
+ V+
Sbjct: 305 DKVV 308
>sp|O43808|PM34_HUMAN Peroxisomal membrane protein PMP34 OS=Homo sapiens
GN=SLC25A17 PE=1 SV=1
Length = 307
Score = 124 bits (311), Expect = 1e-027
Identities = 94/296 (31%), Positives = 142/296 (47%), Gaps = 21/296 (7%)
Frame = -3
Query: 1013 NATAGAVAGFATVAAMHPLDVVRTRFQVNDGRGLSALPTYKNTAHALFTIARLEGLRGGL 834
+A AGAV + PLD R R QV++ R K T L I + EGL
Sbjct: 12 HAVAGAVGSVTAMTVFFPLDTARLRLQVDEKR------KSKTTHMVLLEIIKEEGLLAP- 64
Query: 833 YAGFFPAVIGSTLSWSLYFFFYGRAKQRYGRGRDDDKLTPPLHLASAAEAGALVCFCTNP 654
Y G+FP + S +YF+ + K + +G+ T L AG + T P
Sbjct: 65 YRGWFPVISSLCCSNFVYFYTFNSLKALWVKGQHS---TTGKDLVVGFVAGVVNVLLTTP 121
Query: 653 IWLVKTRLQLQTPLHQTPP-----YSGLLDAFRTIIKEEGPRALYKGILPALLLVSHGAI 489
+W+V TRL+LQ + Y G++DAF II++EG AL+ G P+LLLV + AI
Sbjct: 122 LWVVNTRLKLQGAKFRNEDIVPTNYKGIIDAFHQIIRDEGISALWNGTFPSLLLVFNPAI 181
Query: 488 QFTAYEELRKLIVDFKDKRRNSESTSDNLLNSADYAALGGSSKVAAVLLTYPFQVIRARL 309
QF YE L++ ++ K+R S+ D + A A+ + + + R RL
Sbjct: 182 QFMFYEGLKRQLL----KKRMKLSSLDVFIIGAVAKAIATTVTYPLQTVQSILRFGRHRL 237
Query: 308 QQRPSTNGVPRYIDSLHVIRETARFEGVRGFYRGLTANLLKNVPASSITFIVYENV 141
T G R I L+++ + R G+ G Y+GL A LL+ V +++ F+VYE +
Sbjct: 238 NPENRTLGSLRNI--LYLLHQRVRRFGIMGLYKGLEAKLLQTVLTAALMFLVYEKL 291
>sp|P39953|YEA6_YEAST Probable mitochondrial carrier YEL006W OS=Saccharomyces
cerevisiae GN=YEL006W PE=1 SV=1
Length = 335
Score = 124 bits (311), Expect = 1e-027
Identities = 77/193 (39%), Positives = 110/193 (56%), Gaps = 7/193 (3%)
Frame = -3
Query: 701 ASAAEAGALVCFCTNPIWLVKTRLQLQTPLHQ-TPPYSGLLDAFRTIIKEEGPRALYKGI 525
+SA AGA+ TNPIW+VKTRL LQT + + + Y G +D FR II++EG +ALY G+
Sbjct: 143 SSAITAGAISTVATNPIWVVKTRLMLQTGIGKYSTHYKGTIDTFRKIIQQEGAKALYAGL 202
Query: 524 LPALLLVSHGAIQFTAYEELRKLIVDFKDKRRNSESTSDNLLNSADYAALGGSSKVAAVL 345
+PALL + + AIQF YE L+ + F ST N SK+ A
Sbjct: 203 VPALLGMLNVAIQFPLYENLK---IRFGYSESTDVSTDVTSSNFQKLILASMLSKMVAST 259
Query: 344 LTYPFQVIRARLQQRPS-TNGVPRYIDSLHVIRETARFEGVRGFYRGLTANLLKNVPASS 168
+TYP +++R R+Q + N V R++ L +I+ T R EG GFY G NL++ VPA+
Sbjct: 260 VTYPHEILRTRMQLKSDLPNTVQRHL--LPLIKITYRQEGFAGFYSGFATNLVRTVPAAV 317
Query: 167 ITFIVYENVLKLL 129
+T + +E K L
Sbjct: 318 VTLVSFEYSKKYL 330
>sp|O70579|PM34_MOUSE Peroxisomal membrane protein PMP34 OS=Mus musculus
GN=Slc25a17 PE=2 SV=1
Length = 307
Score = 120 bits (299), Expect = 3e-026
Identities = 91/296 (30%), Positives = 142/296 (47%), Gaps = 21/296 (7%)
Frame = -3
Query: 1013 NATAGAVAGFATVAAMHPLDVVRTRFQVNDGRGLSALPTYKNTAHALFTIARLEGLRGGL 834
+A AGAV + PLD R R QV++ R K T L I + EGL
Sbjct: 12 HAVAGAVGSVTAMTVFFPLDTARLRLQVDEKR------KSKTTHAVLLEIIKEEGLLAP- 64
Query: 833 YAGFFPAVIGSTLSWSLYFFFYGRAKQRYGRGRDDDKLTPPLHLASAAEAGALVCFCTNP 654
Y G+FP + S +YF+ + K + +G+ + + L AG + T P
Sbjct: 65 YRGWFPVISSLCCSNFVYFYTFNSLKAVWVKGQ---RSSTGKDLVVGFVAGVVNVLLTTP 121
Query: 653 IWLVKTRLQLQTPLHQTPP-----YSGLLDAFRTIIKEEGPRALYKGILPALLLVSHGAI 489
+W+V TRL+LQ + Y G++DAF II++EG AL+ G P+LLLV + AI
Sbjct: 122 LWVVNTRLKLQGAKFRNEDIIPTNYKGIIDAFHQIIRDEGILALWNGTFPSLLLVFNPAI 181
Query: 488 QFTAYEELRKLIVDFKDKRRNSESTSDNLLNSADYAALGGSSKVAAVLLTYPFQVIRARL 309
QF YE L++ ++ K+R S+ D + A A+ + + + R RL
Sbjct: 182 QFMFYEGLKRQLL----KKRMKLSSLDVFIIGAIAKAIATTVTYPMQTVQSILRFGRHRL 237
Query: 308 QQRPSTNGVPRYIDSLHVIRETARFEGVRGFYRGLTANLLKNVPASSITFIVYENV 141
T G R + L ++ + + G+ G Y+GL A LL+ V +++ F+VYE +
Sbjct: 238 NPENRTLGSLRNV--LSLLHQRVKRFGIMGLYKGLEAKLLQTVLTAALMFLVYEKL 291
>sp|Q54FU9|MCFW_DICDI Mitochondrial substrate carrier family protein W
OS=Dictyostelium discoideum GN=mcfW PE=3 SV=1
Length = 329
Score = 117 bits (293), Expect = 1e-025
Identities = 70/200 (35%), Positives = 108/200 (54%), Gaps = 14/200 (7%)
Frame = -3
Query: 1007 TAGAVAGFATVAAMHPLDVVRTRFQVNDGRGLSALPTYKNTAHALFTIARLEGLRGGLYA 828
TAG AGF PLDV++T QV++ + + T K+ + R G++ LY
Sbjct: 41 TAGCGAGFMASLFTTPLDVIKTTLQVDNSSNKTIMSTVKS------ILDRKGGVK-NLYL 93
Query: 827 GFFPAVIGSTLSWSLYFFFYGRAKQRYGRGRDD----DKLTPPLHLASAAEAGALVCFCT 660
G P ++G SW++YF Y K+ + + D +K +P + + SA AGA CT
Sbjct: 94 GLKPTLVGQIPSWAVYFSTYTFCKELFTKENDKHSLLEKESPLIFMTSAIIAGAATSICT 153
Query: 659 NPIWLVKTRLQLQTPLHQTPPYSGLLDAFRTIIKEEGPRALYKGILPALLLVSHGAIQFT 480
+PIWL+KTR Q + + Y G++ + +I EEG R LYKG+ P+LL V H +QF
Sbjct: 154 SPIWLIKTRFITQEMVGRQKKYRGIVHSMVSIYHEEGFRGLYKGLGPSLLGVLHVGVQFP 213
Query: 479 AYEELRKLIVDFKDKRRNSE 420
YE+ + ++ K+K +N E
Sbjct: 214 LYEKFKSIL---KEKNKNKE 230
>sp|Q4X022|TPC1_ASPFU Mitochondrial thiamine pyrophosphate carrier 1
OS=Aspergillus fumigatus GN=tpc1 PE=3 SV=3
Length = 317
Score = 115 bits (287), Expect = 7e-025
Identities = 99/309 (32%), Positives = 141/309 (45%), Gaps = 33/309 (10%)
Frame = -3
Query: 1004 AGAVAGFATVAAMHPLDVVRTRFQVNDGRGLS--------ALPTYKNTAHALFTIARLEG 849
+G +AG + + PLDVV+ R Q+ LS P YK T + TI + EG
Sbjct: 20 SGGIAGLVSRFCVAPLDVVKIRLQLQI-HSLSDPASHHDVVGPIYKGTLSTMRTIIKQEG 78
Query: 848 LRGGLYAGFFPAVIGSTLSWSLYFFFYGRAKQRYGRGRDDDKLTPPLH-LASAAEAGALV 672
+ GL+ G PA + +L F Y Q + D +L P L S A AG L
Sbjct: 79 IT-GLWKGNIPAELMYVCYGALQFTAYRTTTQILAQ-LDPHRLPPALESFVSGAVAGGLA 136
Query: 671 CFCTNPIWLVKTRLQLQTPLHQTPPYSGLLDAFRTIIKEEGPRALYKGILPAL-LLVSHG 495
T P+ L++TR Q Y+ LL + R I + EGP ++G A+ +V +
Sbjct: 137 TASTYPLDLLRTRFAAQ---GTERIYTSLLASVRDIARSEGPAGFFRGCSAAVGQIVPYM 193
Query: 494 AIQFTAYEELRKLIVDFKDKRRNSESTSDNLLNSADYAALGGSSKVAAVLLTYPFQVIRA 315
+ F YE LR ++ S +N+ + AA G + V A +P ++R
Sbjct: 194 GLFFATYESLRPVL-----------SGLENMPFGSGDAAAGVIASVLAKSGVFPLDLVRK 242
Query: 314 RLQQRPST------NGVPRYIDSLHVIRETARFEGVRGFYRGLTANLLKNVPASSITFIV 153
RLQ + T +P Y I R +GVRG YRGLT +L+K PAS+IT
Sbjct: 243 RLQVQGPTRTLYVHRNIPEYRGVFSTIAMIVRTQGVRGLYRGLTVSLIKAAPASAITMWT 302
Query: 152 YENVLKLLK 126
YE LKLL+
Sbjct: 303 YERSLKLLR 311
>sp|A1DI57|TPC1_NEOFI Mitochondrial thiamine pyrophosphate carrier 1
OS=Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / FGSC A1164 /
NRRL 181) GN=tpc1 PE=3 SV=1
Length = 317
Score = 111 bits (277), Expect = 1e-023
Identities = 97/308 (31%), Positives = 139/308 (45%), Gaps = 33/308 (10%)
Frame = -3
Query: 1004 AGAVAGFATVAAMHPLDVVRTRFQVNDGRGLS--------ALPTYKNTAHALFTIARLEG 849
+G +AG + + PLDVV+ R Q+ LS P YK T + I + EG
Sbjct: 20 SGGIAGLVSRFCVAPLDVVKIRLQLQI-HSLSDPASHRDVVGPIYKGTLSTMRAIIKQEG 78
Query: 848 LRGGLYAGFFPAVIGSTLSWSLYFFFYGRAKQRYGRGRDDDKLTPPLH-LASAAEAGALV 672
+ GL+ G PA + +L F Y Q + D +L P L S A AG L
Sbjct: 79 IT-GLWKGNIPAELMYVCYGALQFTAYRTTTQVLAQ-LDPHRLPPALESFVSGAVAGGLA 136
Query: 671 CFCTNPIWLVKTRLQLQTPLHQTPPYSGLLDAFRTIIKEEGPRALYKGILPAL-LLVSHG 495
T P+ L++TR Q Y+ LL + + I + EGP ++G A+ +V +
Sbjct: 137 TASTYPLDLLRTRFAAQ---GTERIYTSLLASVQDIARNEGPAGFFRGCSAAVGQIVPYM 193
Query: 494 AIQFTAYEELRKLIVDFKDKRRNSESTSDNLLNSADYAALGGSSKVAAVLLTYPFQVIRA 315
+ F YE LR ++ S +N+ + AA G + V A +P ++R
Sbjct: 194 GLFFATYESLRPVL-----------SGLENMPFGSGDAAAGVIASVLAKTGVFPLDLVRK 242
Query: 314 RLQQRPST------NGVPRYIDSLHVIRETARFEGVRGFYRGLTANLLKNVPASSITFIV 153
RLQ + T +P Y I R +GVRG YRGLT +L+K PAS+IT
Sbjct: 243 RLQVQGPTRTLYVHRNIPEYRGVFSTIAMIVRTQGVRGLYRGLTVSLIKAAPASAITMWT 302
Query: 152 YENVLKLL 129
YE LKLL
Sbjct: 303 YERSLKLL 310
>sp|A4RF23|TPC1_MAGGR Mitochondrial thiamine pyrophosphate carrier 1
OS=Magnaporthe grisea GN=TPC1 PE=3 SV=2
Length = 327
Score = 108 bits (268), Expect = 1e-022
Identities = 95/311 (30%), Positives = 131/311 (42%), Gaps = 32/311 (10%)
Frame = -3
Query: 1004 AGAVAGFATVAAMHPLDVVRTRFQVND----------GRGLSALPTYKNTAHALFTIARL 855
AGA AG + PLDVV+ R Q+ L P YK T + IAR
Sbjct: 21 AGATAGMIARFVIAPLDVVKIRLQLQTHSLSDPLSQRAELLRGGPVYKGTLSTMRHIARQ 80
Query: 854 EGLRGGLYAGFFPAVIGSTLSWSLYFFFYGRAKQRYGRGRDDDKLTPPL--HLASAAEAG 681
EG+ GL+ G PA + ++ F Y A Q R +D+ P + A AG
Sbjct: 81 EGIT-GLWKGNVPAELLYITYSAVQFATYRSAAQLLHRVAGEDRQLPAAAESFVAGAAAG 139
Query: 680 ALVCFCTNPIWLVKTRLQLQTPLHQTPPYSGLLDAFRTIIKEEGPRALYKGILPAL-LLV 504
T P+ L++TR Q Y L A I ++EG R ++GI PA+
Sbjct: 140 VTSTTVTYPLDLLRTRFAAQGS-GDDRVYQSLRRAVADIWRDEGYRGFFRGIGPAVGQTF 198
Query: 503 SHGAIQFTAYEELRKLIVDFKDKRRNSESTSDNLLNSADYAALGGSSKVAAVLLTYPFQV 324
I F AYE LR + D K A ++ A +P +
Sbjct: 199 PFMGIFFAAYESLRAPLADLKLP-----------FWGGQLALASMTASTLAKTAVFPLDL 247
Query: 323 IRARLQQRPST------NGVPRYIDSLHVIRETARFEGVRGFYRGLTANLLKNVPASSIT 162
+R R+Q + T +P Y + I AR EG RG YRGLT +L+K+ PAS++T
Sbjct: 248 VRRRIQVQGPTRSKYVHKNIPEYKGTFSTISTIARTEGFRGLYRGLTVSLIKSAPASAVT 307
Query: 161 FIVYENVLKLL 129
YE VL+ L
Sbjct: 308 MWTYERVLRAL 318
>sp|Q54BM3|MCFG_DICDI Mitochondrial substrate carrier family protein G
OS=Dictyostelium discoideum GN=mcfG PE=2 SV=1
Length = 300
Score = 107 bits (267), Expect = 1e-022
Identities = 79/299 (26%), Positives = 137/299 (45%), Gaps = 17/299 (5%)
Frame = -3
Query: 1016 ENATAGAVAGFATVAAMHPLDVVRTRFQVNDGRGLSALPTYKNTAHALFTIARLEGLRGG 837
++ AG++ G V HPLD ++ R Q P Y T L EG G
Sbjct: 15 KDIVAGSIGGVGQVFTGHPLDTIKVRLQTQS----VGNPIYSGTMDCLKKTISQEGF-AG 69
Query: 836 LYAGFFPAVIGSTLSWSLYFFFYGRAKQRYGRGRDDDKLTPPLH--LASAAEAGALVCFC 663
LY G ++G ++ S+ F YG++K + D+ L A+ A AG + F
Sbjct: 70 LYKGVASPLVGLSIMNSVMFLAYGQSKTLIQKLSDNPNEALDLKGLTAAGALAGIAIGFV 129
Query: 662 TNPIWLVKTRLQLQTPLHQTPPYSGLLDAFRTIIKEEGPRALYKGILPALLL-VSHGAIQ 486
P+ L K+++Q+Q Y D + I K G R +++G+ L+ + A
Sbjct: 130 DAPVDLFKSQMQVQQ--GDKNQYKSTADCAKQIWKVGGVRGVFQGLGATLVRDIPANACY 187
Query: 485 FTAYEELRKLIVDFKDKRRNSESTSDNLLNSADYAALGGSSKVAAVLLTYPFQVIRARLQ 306
F AYE R + + ++ S N L+S A GG+ V+ LTYP V+++ +Q
Sbjct: 188 FGAYELCRDFLA-------SKDNISVNQLSSLQIMAAGGAGGVSYWTLTYPADVVKSTMQ 240
Query: 305 QRPSTNGVPRYIDSLHVIRETARFEGVRGFYRGLTANLLKNVPASSITFIVYENVLKLL 129
+Y + + + + +G+ GFY+G T +++VPA++ F++YE +++
Sbjct: 241 TDAIVKSQRKYKNMIDCASKIYKQQGIAGFYKGFTPCFIRSVPANAACFVLYEKARQIM 299
>sp|B0G159|MCFC_DICDI Mitochondrial substrate carrier family protein C
OS=Dictyostelium discoideum GN=mcfC PE=2 SV=1
Length = 472
Score = 98 bits (242), Expect = 1e-019
Identities = 74/292 (25%), Positives = 134/292 (45%), Gaps = 25/292 (8%)
Frame = -3
Query: 1004 AGAVAGFATVAAMHPLDVVRTRFQVNDGRGLSALPTYKNTAHALFTIARLEGLRGGLYAG 825
AG+VAGFA+ + PL+ V+ Q+N G+ +S + +K +G G + G
Sbjct: 192 AGSVAGFASRTSTAPLERVKIMCQLNHGKPISLISAFK--------ACYKDGGIKGFFRG 243
Query: 824 FFPAVIGSTLSWSLYFFFYGRAKQRYGRGRDDDKLTPPLHLASAAEAGALVCFCTNPIWL 645
+I + ++ F Y K+ + +D +LT S + AG + P+ +
Sbjct: 244 NLANIIKVSPESAVKFGTYEYVKKLF--AENDCELTSAQRFISGSVAGVVSHTTLFPLEV 301
Query: 644 VKTRLQLQTPLHQTPPYSGLLDAFRTI-IKEEGPRALYKGILPAL-LLVSHGAIQFTAYE 471
V+ RL + Y+G+ D F+ I I E+ R Y+G+ ++ + H + YE
Sbjct: 302 VRLRLSAEI----AGTYNGIFDCFKKIAISEKSIRPFYRGLGASITATIPHSGVNMMVYE 357
Query: 470 ELRKLIVDFKDKRRNSESTSDNLLNSADYAALGGSSKVAAVLLTYPFQVIRARLQQRPST 291
L+ ++ + T + + +S V L+ YPF V+++RL + S+
Sbjct: 358 FLKHKVI---------KMTGNEFPTAGQLLVCASTSSVCGQLVGYPFHVVKSRLITQGSS 408
Query: 290 NGVPRYIDSLHVIRETARFEGVRGFYRGLTANLLKNVPASSITFIVYENVLK 135
+Y + + + EG G Y+G+ + +K++P+ SITFIVYE K
Sbjct: 409 VNQEKYTGLFDGLTKIIKKEGPIGLYKGIVPSFMKSIPSHSITFIVYEGFKK 460
>sp|A7ER02|TPC1_SCLS1 Mitochondrial thiamine pyrophosphate carrier 1
OS=Sclerotinia sclerotiorum (strain ATCC 18683 / 1980 / Ss-1) GN=tpc1
PE=3 SV=1
Length = 322
Score = 80 bits (196), Expect = 2e-014
Identities = 64/197 (32%), Positives = 90/197 (45%), Gaps = 22/197 (11%)
Frame = -3
Query: 698 SAAEAGALVCFCTNPIWLVKTRLQLQTPLHQTPPYSGLLDAFRTIIKEEGPRALYKGILP 519
+ A AGA+ T P+ L++TR Q Y+ L + R I EGPR ++G+
Sbjct: 130 AGASAGAVATTATYPLDLLRTRFAAQ---GVERIYTSLRASIRDIAVNEGPRGFFQGLGA 186
Query: 518 AL-LLVSHGAIQFTAYEELRKLIVDFKDKRRNSESTSDNLLNSADYAALGGSSKVAAVLL 342
+ ++ + I F YE LR + T S D A G + V A
Sbjct: 187 GVGQIIPYMGIFFATYETLRVPL-----------GTLHMPFGSGD-ATAGVLASVIAKTG 234
Query: 341 TYPFQVIRARLQQRPST------NGVPRYIDSLHVIRETARFEGVRGFYRGLTANLLKNV 180
+PF +IR RLQ + T +P Y +R + EG RG YRGLT +L K
Sbjct: 235 IFPFDLIRKRLQVQGPTRERYVHKNIPVYNGVFRTMRHIIQNEGYRGLYRGLTVSLFKAA 294
Query: 179 PASSITFIVYENVLKLL 129
PAS++T YE VL+LL
Sbjct: 295 PASAVTMWTYERVLRLL 311
>sp|O94502|YBT5_SCHPO Uncharacterized mitochondrial carrier C12D12.05c
OS=Schizosaccharomyces pombe GN=SPBC12D12.05c PE=2 SV=2
Length = 426
Score = 80 bits (196), Expect = 2e-014
Identities = 59/221 (26%), Positives = 97/221 (43%), Gaps = 2/221 (0%)
Frame = -3
Query: 788 SLYFFFYGRAKQRYGRGRDDDKLTPPLHLASAAEAGALVCFCTNPIWLVKTRLQLQTPLH 609
S+ F Y K+ G + +P + AG++ P+ +K R+Q
Sbjct: 204 SIKFGTYEAMKRVLGISSSSENHSPLYSYLAGGMAGSVAQMFIYPVDTLKFRIQCSDLSR 263
Query: 608 QTPPYSGLLDAFRTIIKEEGPRALYKGILPALL-LVSHGAIQFTAYEELRKLIVDFKDKR 432
S +L + + K G R Y+G+L +L + + A +E L++ + R
Sbjct: 264 GQHGKSIILSNAKELYKSVGIRGYYRGVLVGILGMFPYSATDLGTFEGLKRTWIGILASR 323
Query: 431 RNSESTSDNLLNSADYAALGGSSKVAAVLLTYPFQVIRARLQQRPSTNGVPRYIDSLHVI 252
N + L N A G S + +P VIR RLQ + ++ Y +
Sbjct: 324 DNVDPQDVKLPNGL-VMAFGALSGSTGATIVFPLNVIRTRLQTQGTSAHPATYDGFIDCF 382
Query: 251 RETARFEGVRGFYRGLTANLLKNVPASSITFIVYENVLKLL 129
+T + EG RG Y+GL+ NLLK P+ +I+++VYEN K L
Sbjct: 383 YKTTKNEGFRGLYKGLSPNLLKVAPSVAISYLVYENCKKWL 423
>sp|Q1E7P0|TPC1_COCIM Mitochondrial thiamine pyrophosphate carrier 1
OS=Coccidioides immitis GN=TPC1 PE=3 SV=1
Length = 319
Score = 63 bits (152), Expect = 3e-009
Identities = 36/93 (38%), Positives = 50/93 (53%), Gaps = 6/93 (6%)
Frame = -3
Query: 383 AALGGSSKVAAVLLTYPFQVIRARLQQRPST------NGVPRYIDSLHVIRETARFEGVR 222
A G + V A +P ++R RLQ + T +P Y L ++ R GVR
Sbjct: 220 ATAGVIASVIAKTGVFPLDLVRKRLQVQGPTRSRYIHQNIPEYNGVLSTMKMVLRDGGVR 279
Query: 221 GFYRGLTANLLKNVPASSITFIVYENVLKLLKQ 123
G YRGLT +L+K PAS++T YE VLK+LK+
Sbjct: 280 GLYRGLTVSLIKAAPASAVTMWTYERVLKILKE 312
>sp|Q9UTD6|YID3_SCHPO Uncharacterized mitochondrial carrier C227.03c
OS=Schizosaccharomyces pombe GN=SPAC227.03c PE=2 SV=1
Length = 371
Score = 52 bits (123), Expect = 7e-006
Identities = 25/60 (41%), Positives = 33/60 (55%)
Frame = -3
Query: 605 TPPYSGLLDAFRTIIKEEGPRALYKGILPALLLVSHGAIQFTAYEELRKLIVDFKDKRRN 426
+P Y+ DAFR I K EG A Y+G+ P+L H IQF YE + + DF K+ N
Sbjct: 227 SPAYNNTFDAFRKIYKYEGLAAFYRGLFPSLFGTLHVGIQFPLYEYFKSFLDDFFGKKSN 286
Database: UniProt/SwissProt
Posted date: Sat Aug 07 14:36:18 2010
Number of letters in database: 182,829,261
Number of sequences in database: 518,415
Lambda K H
0.267 0.041 0.140
Gapped
Lambda K H
0.267 0.041 0.140
Matrix: blosum62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 133,766,061,048
Number of Sequences: 518415
Number of Extensions: 133766061048
Number of Successful Extensions: 831469033
Number of sequences better than 0.0: 0
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