BLASTX 7.6.2
Query= UN34407 /QuerySize=1607
(1606 letters)
Database: UniProt/SwissProt;
518,415 sequences; 182,829,261 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|O81027|HMGCL_ARATH Hydroxymethylglutaryl-CoA lyase, mitochond... 551 6e-156
sp|P97519|HMGCL_RAT Hydroxymethylglutaryl-CoA lyase, mitochondri... 384 9e-106
sp|P35915|HMGCL_CHICK Hydroxymethylglutaryl-CoA lyase OS=Gallus ... 383 3e-105
sp|Q8JZS7|HMGC2_MOUSE Probable 3-hydroxymethyl-3-methylglutaryl-... 380 2e-104
sp|P38060|HMGCL_MOUSE Hydroxymethylglutaryl-CoA lyase, mitochond... 377 1e-103
sp|Q8TB92|HMGC2_HUMAN Probable 3-hydroxymethyl-3-methylglutaryl-... 377 1e-103
sp|Q29448|HMGCL_BOVIN Hydroxymethylglutaryl-CoA lyase, mitochond... 377 2e-103
sp|A8WG57|HMGC2_DANRE Probable 3-hydroxymethyl-3-methylglutaryl-... 376 3e-103
sp|Q5R9E1|HMGCL_PONAB Hydroxymethylglutaryl-CoA lyase, mitochond... 376 3e-103
sp|P35914|HMGCL_HUMAN Hydroxymethylglutaryl-CoA lyase, mitochond... 374 2e-102
sp|Q8HXZ6|HMGCL_MACFA Hydroxymethylglutaryl-CoA lyase, mitochond... 373 3e-102
sp|P13703|HMGCL_PSEMV Hydroxymethylglutaryl-CoA lyase OS=Pseudom... 297 2e-079
sp|O34873|HMGCL_BACSU Hydroxymethylglutaryl-CoA lyase yngG OS=Ba... 257 3e-067
>sp|O81027|HMGCL_ARATH Hydroxymethylglutaryl-CoA lyase, mitochondrial
OS=Arabidopsis thaliana GN=HMGCL PE=1 SV=2
Length = 468
Score = 551 bits (1419), Expect = 6e-156
Identities = 285/317 (89%), Positives = 299/317 (94%), Gaps = 3/317 (0%)
Frame = -3
Query: 1124 HSLNKQQLLREVPKFVKIVEVGPRDGLQNEKNIVPTSVKVELIRRLVSAGLPVVEATSFV 945
H NK + + +PKFVKIVEVGPRDGLQNEKNIVPTSVKVELI+RLVS+GLPVVEATSFV
Sbjct: 155 HISNK--ISKGIPKFVKIVEVGPRDGLQNEKNIVPTSVKVELIQRLVSSGLPVVEATSFV 212
Query: 944 SPKWVPQLADAKNVMDAVNTLHGAARLPVLTPNLKGFEAAVSAGAKEVAIFASASESFSL 765
SPKWVPQLADAK+VMDAVNTL G ARLPVLTPNLKGF+AAVSAGAKEVAIFASASESFSL
Sbjct: 213 SPKWVPQLADAKDVMDAVNTLDG-ARLPVLTPNLKGFQAAVSAGAKEVAIFASASESFSL 271
Query: 764 SNINCTIEESLLRYRAVSTAAKEHSFPVRAYVSCAVGCPVEGAVPPSKVAHVVKELYDMG 585
SNINCTIEESLLRYR V+TAAKEHS PVR YVSC VGCPVEG V PSKVA+VVKELYDMG
Sbjct: 272 SNINCTIEESLLRYRVVATAAKEHSVPVRGYVSCVVGCPVEGPVLPSKVAYVVKELYDMG 331
Query: 584 CFEISLGDTIGIGTPGSVVPMLEAVMAAVPAEKLAVHFHDTYGQALANILVSLQMGINIV 405
CFEISLGDTIGIGTPGSVVPMLEAVMA VPA+KLAVHFHDTYGQALANILVSLQMGI+IV
Sbjct: 332 CFEISLGDTIGIGTPGSVVPMLEAVMAVVPADKLAVHFHDTYGQALANILVSLQMGISIV 391
Query: 404 DSSVAGLGGCPYAKGVSGNVATEDVVYMLNGLGVQTNVDLGKLIAAGDFISKHLGRPNGS 225
DSS+AGLGGCPYAKG SGNVATEDVVYMLNGLGV TNVDLGKLIAAGDFISKHLGRPNGS
Sbjct: 392 DSSIAGLGGCPYAKGASGNVATEDVVYMLNGLGVHTNVDLGKLIAAGDFISKHLGRPNGS 451
Query: 224 KAAVALSHRITADASKL 174
KAAVAL+ RITADASK+
Sbjct: 452 KAAVALNRRITADASKI 468
>sp|P97519|HMGCL_RAT Hydroxymethylglutaryl-CoA lyase, mitochondrial OS=Rattus
norvegicus GN=Hmgcl PE=2 SV=1
Length = 325
Score = 384 bits (986), Expect = 9e-106
Identities = 194/294 (65%), Positives = 229/294 (77%), Gaps = 1/294 (0%)
Frame = -3
Query: 1091 VPKFVKIVEVGPRDGLQNEKNIVPTSVKVELIRRLVSAGLPVVEATSFVSPKWVPQLADA 912
+PK VKIVEVGPRDGLQNEK+IVPT VK++LI L AGLPV+EATSFVSPKWVPQ+AD
Sbjct: 29 LPKRVKIVEVGPRDGLQNEKSIVPTPVKIKLIDMLSEAGLPVIEATSFVSPKWVPQMADH 88
Query: 911 KNVMDAVNTLHGAARLPVLTPNLKGFEAAVSAGAKEVAIFASASESFSLSNINCTIEESL 732
+V+ + G PVLTPN+KGFE AV+AGAKEV+IF +ASE F+ N+NC+IEES
Sbjct: 89 SDVLKGIQKFPG-INYPVLTPNMKGFEEAVAAGAKEVSIFGAASELFTRKNVNCSIEESF 147
Query: 731 LRYRAVSTAAKEHSFPVRAYVSCAVGCPVEGAVPPSKVAHVVKELYDMGCFEISLGDTIG 552
R+ V AA+ S VR YVSCA+GCP EG V P+KVA V K+LY MGC+EISLGDTIG
Sbjct: 148 QRFDGVMQAARAASISVRGYVSCALGCPYEGKVSPAKVAEVAKKLYSMGCYEISLGDTIG 207
Query: 551 IGTPGSVVPMLEAVMAAVPAEKLAVHFHDTYGQALANILVSLQMGINIVDSSVAGLGGCP 372
+GTPG + ML AV+ VP LAVH HDTYGQALAN LV+LQMG+++VDSSVAGLGGCP
Sbjct: 208 VGTPGLMKDMLTAVLHEVPVAALAVHCHDTYGQALANTLVALQMGVSVVDSSVAGLGGCP 267
Query: 371 YAKGVSGNVATEDVVYMLNGLGVQTNVDLGKLIAAGDFISKHLGRPNGSKAAVA 210
YAKG SGN+ATED+VYML GLG+ T V+L KL+ AGDFI + L R SK A A
Sbjct: 268 YAKGASGNLATEDLVYMLTGLGIHTGVNLQKLLEAGDFICQALNRKTSSKVAQA 321
>sp|P35915|HMGCL_CHICK Hydroxymethylglutaryl-CoA lyase OS=Gallus gallus GN=HMGCL
PE=1 SV=1
Length = 298
Score = 383 bits (982), Expect = 3e-105
Identities = 193/293 (65%), Positives = 228/293 (77%), Gaps = 1/293 (0%)
Frame = -3
Query: 1088 PKFVKIVEVGPRDGLQNEKNIVPTSVKVELIRRLVSAGLPVVEATSFVSPKWVPQLADAK 909
P+ VK+VEVGPRDGLQNEK++VPT VK+ LI L GLPV+EATSFVSP+WVPQ+AD
Sbjct: 3 PQRVKVVEVGPRDGLQNEKSVVPTPVKIRLIDMLSETGLPVIEATSFVSPRWVPQMADHA 62
Query: 908 NVMDAVNTLHGAARLPVLTPNLKGFEAAVSAGAKEVAIFASASESFSLSNINCTIEESLL 729
VM +N L G + PVLTPNLKGF+AAV+AGAKEV+IF +ASE F+ NINC+IEESL
Sbjct: 63 EVMQGINKLPGVS-YPVLTPNLKGFQAAVAAGAKEVSIFGAASELFTKKNINCSIEESLE 121
Query: 728 RYRAVSTAAKEHSFPVRAYVSCAVGCPVEGAVPPSKVAHVVKELYDMGCFEISLGDTIGI 549
R+ V AA+ S PVR YVSC +GCP EG + +KVA V K++Y MGC+EISLGD IGI
Sbjct: 122 RFSEVMNAARAASIPVRGYVSCVLGCPYEGNISAAKVAEVSKKMYSMGCYEISLGDRIGI 181
Query: 548 GTPGSVVPMLEAVMAAVPAEKLAVHFHDTYGQALANILVSLQMGINIVDSSVAGLGGCPY 369
GTPGS+ ML AVM VP LAVH HDTYGQALANILV+LQMG+++VD+SVAGLGGCPY
Sbjct: 182 GTPGSMKEMLAAVMKEVPVGALAVHCHDTYGQALANILVALQMGVSVVDASVAGLGGCPY 241
Query: 368 AKGVSGNVATEDVVYMLNGLGVQTNVDLGKLIAAGDFISKHLGRPNGSKAAVA 210
A+G SGNVATED+VYMLNGLG+ T VDL KL+ G FI L R SK + A
Sbjct: 242 AQGASGNVATEDLVYMLNGLGIHTGVDLQKLMDTGTFICNALNRRTNSKVSQA 294
>sp|Q8JZS7|HMGC2_MOUSE Probable 3-hydroxymethyl-3-methylglutaryl-CoA lyase 2
OS=Mus musculus GN=Hmgcll1 PE=2 SV=1
Length = 343
Score = 380 bits (974), Expect = 2e-104
Identities = 186/294 (63%), Positives = 230/294 (78%), Gaps = 1/294 (0%)
Frame = -3
Query: 1091 VPKFVKIVEVGPRDGLQNEKNIVPTSVKVELIRRLVSAGLPVVEATSFVSPKWVPQLADA 912
+P++VKIVEVGPRDGLQNEK IVPT +K+ELI +L GL V+E TSFVS +WVPQ+AD
Sbjct: 44 LPEYVKIVEVGPRDGLQNEKVIVPTDIKIELINQLSQTGLSVIEVTSFVSSRWVPQMADH 103
Query: 911 KNVMDAVNTLHGAARLPVLTPNLKGFEAAVSAGAKEVAIFASASESFSLSNINCTIEESL 732
VM + G R PVLTPNL+GF+ AV+AGA E+A+F +ASESFS NINC+IEES+
Sbjct: 104 AEVMRGIRQYPG-VRYPVLTPNLQGFQHAVAAGATEIAVFGAASESFSKKNINCSIEESM 162
Query: 731 LRYRAVSTAAKEHSFPVRAYVSCAVGCPVEGAVPPSKVAHVVKELYDMGCFEISLGDTIG 552
R++ V ++A+ PVR YVSCA+GCP EG++ P KV V K LY MGC+EISLGDTIG
Sbjct: 163 GRFQEVISSARHMDIPVRGYVSCALGCPYEGSITPQKVTEVSKRLYGMGCYEISLGDTIG 222
Query: 551 IGTPGSVVPMLEAVMAAVPAEKLAVHFHDTYGQALANILVSLQMGINIVDSSVAGLGGCP 372
+GTPGS+ MLE+VM +P LAVH HDTYGQALANIL +LQMGIN+VDS+V+GLGGCP
Sbjct: 223 VGTPGSMKMMLESVMKEIPPGALAVHCHDTYGQALANILTALQMGINVVDSAVSGLGGCP 282
Query: 371 YAKGVSGNVATEDVVYMLNGLGVQTNVDLGKLIAAGDFISKHLGRPNGSKAAVA 210
YAKG SGNVATED++YMLNG+G+ T VDL K++ AG+FI K + + SK A A
Sbjct: 283 YAKGASGNVATEDLIYMLNGMGLNTGVDLYKVMEAGEFICKAVNKTTNSKVAQA 336
>sp|P38060|HMGCL_MOUSE Hydroxymethylglutaryl-CoA lyase, mitochondrial OS=Mus
musculus GN=Hmgcl PE=1 SV=1
Length = 325
Score = 377 bits (968), Expect = 1e-103
Identities = 191/294 (64%), Positives = 224/294 (76%), Gaps = 1/294 (0%)
Frame = -3
Query: 1091 VPKFVKIVEVGPRDGLQNEKNIVPTSVKVELIRRLVSAGLPVVEATSFVSPKWVPQLADA 912
+PK VKIVEVGPRDGLQNEK+IVPT VK+ LI L AGLPV+EATSFVSP WVPQ+AD
Sbjct: 29 LPKQVKIVEVGPRDGLQNEKSIVPTPVKIRLIDMLSEAGLPVIEATSFVSPNWVPQMADH 88
Query: 911 KNVMDAVNTLHGAARLPVLTPNLKGFEAAVSAGAKEVAIFASASESFSLSNINCTIEESL 732
+V+ + G PVLTPN+KGFE AV+AGAKEV++F + SE F+ N NC+IEES
Sbjct: 89 SDVLKGIQKFPG-INYPVLTPNMKGFEEAVAAGAKEVSVFGAVSELFTRKNANCSIEESF 147
Query: 731 LRYRAVSTAAKEHSFPVRAYVSCAVGCPVEGAVPPSKVAHVVKELYDMGCFEISLGDTIG 552
R+ V AA+ S VR YVSCA+GCP EG V P+KVA V K+LY MGC+EISLGDTIG
Sbjct: 148 QRFAGVMQAAQAASISVRGYVSCALGCPYEGKVSPAKVAEVAKKLYSMGCYEISLGDTIG 207
Query: 551 IGTPGSVVPMLEAVMAAVPAEKLAVHFHDTYGQALANILVSLQMGINIVDSSVAGLGGCP 372
+GTPG + ML AVM VP L VH HDT GQALAN LV+LQMG+++VDSSVAGLGGCP
Sbjct: 208 VGTPGLMKDMLTAVMHEVPVTALGVHCHDTIGQALANTLVALQMGVSVVDSSVAGLGGCP 267
Query: 371 YAKGVSGNVATEDVVYMLNGLGVQTNVDLGKLIAAGDFISKHLGRPNGSKAAVA 210
YAKG SGN+ATED+VYMLNGLG+ T V+L KL+ AGDFI + L R SK A A
Sbjct: 268 YAKGASGNLATEDLVYMLNGLGIHTGVNLQKLLEAGDFICQALNRKTSSKVAQA 321
>sp|Q8TB92|HMGC2_HUMAN Probable 3-hydroxymethyl-3-methylglutaryl-CoA lyase 2
OS=Homo sapiens GN=HMGCLL1 PE=2 SV=3
Length = 370
Score = 377 bits (967), Expect = 1e-103
Identities = 186/297 (62%), Positives = 228/297 (76%), Gaps = 1/297 (0%)
Frame = -3
Query: 1100 LREVPKFVKIVEVGPRDGLQNEKNIVPTSVKVELIRRLVSAGLPVVEATSFVSPKWVPQL 921
L +P+FVKIVEVGPRDGLQNEK IVPT +K+E I RL GL V+E TSFVS +WVPQ+
Sbjct: 71 LSGLPEFVKIVEVGPRDGLQNEKVIVPTDIKIEFINRLSQTGLSVIEVTSFVSSRWVPQM 130
Query: 920 ADAKNVMDAVNTLHGAARLPVLTPNLKGFEAAVSAGAKEVAIFASASESFSLSNINCTIE 741
AD VM ++ G R PVLTPNL+GF AV+AGA E+++F +ASESFS NINC+IE
Sbjct: 131 ADHTEVMKGIHQYPG-VRYPVLTPNLQGFHHAVAAGATEISVFGAASESFSKKNINCSIE 189
Query: 740 ESLLRYRAVSTAAKEHSFPVRAYVSCAVGCPVEGAVPPSKVAHVVKELYDMGCFEISLGD 561
ES+ ++ V +A+ + P R YVSCA+GCP EG++ P KV V K LY MGC+EISLGD
Sbjct: 190 ESMGKFEEVVKSARHMNIPARGYVSCALGCPYEGSITPQKVTEVSKRLYGMGCYEISLGD 249
Query: 560 TIGIGTPGSVVPMLEAVMAAVPAEKLAVHFHDTYGQALANILVSLQMGINIVDSSVAGLG 381
TIG+GTPGS+ MLE+VM +P LAVH HDTYGQALANIL +LQMGIN+VDS+V+GLG
Sbjct: 250 TIGVGTPGSMKRMLESVMKEIPPGALAVHCHDTYGQALANILTALQMGINVVDSAVSGLG 309
Query: 380 GCPYAKGVSGNVATEDVVYMLNGLGVQTNVDLGKLIAAGDFISKHLGRPNGSKAAVA 210
GCPYAKG SGNVATED++YMLNGLG+ T V+L K++ AGDFI K + + SK A A
Sbjct: 310 GCPYAKGASGNVATEDLIYMLNGLGLNTGVNLYKVMEAGDFICKAVNKTTNSKVAQA 366
>sp|Q29448|HMGCL_BOVIN Hydroxymethylglutaryl-CoA lyase, mitochondrial OS=Bos
taurus GN=HMGCL PE=2 SV=2
Length = 325
Score = 377 bits (966), Expect = 2e-103
Identities = 190/293 (64%), Positives = 225/293 (76%), Gaps = 1/293 (0%)
Frame = -3
Query: 1088 PKFVKIVEVGPRDGLQNEKNIVPTSVKVELIRRLVSAGLPVVEATSFVSPKWVPQLADAK 909
PK VKIVEVGPRDGLQNEKNIVPT VK++LI L AGLPVVEATSFVSPKWVPQ+AD
Sbjct: 30 PKQVKIVEVGPRDGLQNEKNIVPTPVKIKLIDMLSEAGLPVVEATSFVSPKWVPQMADHA 89
Query: 908 NVMDAVNTLHGAARLPVLTPNLKGFEAAVSAGAKEVAIFASASESFSLSNINCTIEESLL 729
V+ + G PVLTPN KGF+AAV+AGAKEVAIF +ASE F+ NINC+I+ESL
Sbjct: 90 EVLKGIQKFPG-VNYPVLTPNFKGFQAAVAAGAKEVAIFGAASELFTKKNINCSIDESLQ 148
Query: 728 RYRAVSTAAKEHSFPVRAYVSCAVGCPVEGAVPPSKVAHVVKELYDMGCFEISLGDTIGI 549
R+ + AA+ VR YVSC +GCP EG + P+KVA V K+LY MGC+EISLGDTIG+
Sbjct: 149 RFDEILKAARAAGISVRGYVSCVLGCPYEGKISPAKVAEVTKKLYSMGCYEISLGDTIGV 208
Query: 548 GTPGSVVPMLEAVMAAVPAEKLAVHFHDTYGQALANILVSLQMGINIVDSSVAGLGGCPY 369
GTPG++ ML AV+ VP LAVH HDTYGQALAN L +LQMG++++DSSVAGLGGCPY
Sbjct: 209 GTPGAMKDMLSAVLQEVPVTALAVHCHDTYGQALANTLTALQMGVSVMDSSVAGLGGCPY 268
Query: 368 AKGVSGNVATEDVVYMLNGLGVQTNVDLGKLIAAGDFISKHLGRPNGSKAAVA 210
A+G SGN+ATED+VYML GLG+ T V+L KL+ AG FI + L R SK A A
Sbjct: 269 AQGASGNLATEDLVYMLAGLGIHTGVNLQKLLEAGAFICQALNRRTNSKVAQA 321
>sp|A8WG57|HMGC2_DANRE Probable 3-hydroxymethyl-3-methylglutaryl-CoA lyase 2
OS=Danio rerio GN=hmgcll1 PE=2 SV=1
Length = 335
Score = 376 bits (965), Expect = 3e-103
Identities = 191/317 (60%), Positives = 238/317 (75%), Gaps = 3/317 (0%)
Frame = -3
Query: 1154 TLSKHFHTLPHSL--NKQQLLREVPKFVKIVEVGPRDGLQNEKNIVPTSVKVELIRRLVS 981
T + + LP L K L ++P +VKIVEVGPRDGLQNEK IVPT VK++LI L
Sbjct: 16 TFLRDYPWLPRLLWEEKCSELPKLPVYVKIVEVGPRDGLQNEKEIVPTEVKIQLIDLLSQ 75
Query: 980 AGLPVVEATSFVSPKWVPQLADAKNVMDAVNTLHGAARLPVLTPNLKGFEAAVSAGAKEV 801
GLPV+EATSFVS KWV Q+AD V+ + R PVLTPN++GF+AAV+AGA EV
Sbjct: 76 TGLPVIEATSFVSSKWVAQMADHTAVLKGIKR-SPDVRYPVLTPNIQGFQAAVAAGANEV 134
Query: 800 AIFASASESFSLSNINCTIEESLLRYRAVSTAAKEHSFPVRAYVSCAVGCPVEGAVPPSK 621
A+F SASE+FS NINC+IEESL R+ V +AAK+ PVR YVSCA+GCP EG V PS+
Sbjct: 135 AVFGSASETFSRKNINCSIEESLQRFEQVVSAAKQEGIPVRGYVSCALGCPYEGQVKPSQ 194
Query: 620 VAHVVKELYDMGCFEISLGDTIGIGTPGSVVPMLEAVMAAVPAEKLAVHFHDTYGQALAN 441
V V K L+++GC+E+SLGDTIG+GT GS+ ML V+ VPA LAVH HDTYGQAL N
Sbjct: 195 VTKVAKRLFELGCYEVSLGDTIGVGTAGSMAEMLSDVLTEVPAGALAVHCHDTYGQALPN 254
Query: 440 ILVSLQMGINIVDSSVAGLGGCPYAKGVSGNVATEDVVYMLNGLGVQTNVDLGKLIAAGD 261
IL++LQMG+++VD+SVAGLGGCP+AKG SGNV+TED++YML+GLG++T VDL K++ AGD
Sbjct: 255 ILIALQMGVSVVDASVAGLGGCPFAKGASGNVSTEDLLYMLHGLGIETGVDLLKVMEAGD 314
Query: 260 FISKHLGRPNGSKAAVA 210
FI K L R SK + A
Sbjct: 315 FICKALNRKTNSKVSQA 331
>sp|Q5R9E1|HMGCL_PONAB Hydroxymethylglutaryl-CoA lyase, mitochondrial OS=Pongo
abelii GN=HMGCL PE=2 SV=1
Length = 325
Score = 376 bits (965), Expect = 3e-103
Identities = 191/294 (64%), Positives = 226/294 (76%), Gaps = 1/294 (0%)
Frame = -3
Query: 1091 VPKFVKIVEVGPRDGLQNEKNIVPTSVKVELIRRLVSAGLPVVEATSFVSPKWVPQLADA 912
+PK VKIVEVGPRDGLQNEKNIV T VK++LI L AGL V+E TSFVSPKWVPQ+ D
Sbjct: 29 LPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLIDMLSEAGLSVIETTSFVSPKWVPQMGDH 88
Query: 911 KNVMDAVNTLHGAARLPVLTPNLKGFEAAVSAGAKEVAIFASASESFSLSNINCTIEESL 732
V+ + G PVLTPNLKGFEAAV+AGAKEVAIF +ASE F+ NINC+IEES
Sbjct: 89 TEVLKGIQKFPG-INYPVLTPNLKGFEAAVAAGAKEVAIFGAASELFTKKNINCSIEESF 147
Query: 731 LRYRAVSTAAKEHSFPVRAYVSCAVGCPVEGAVPPSKVAHVVKELYDMGCFEISLGDTIG 552
R+ A+ AA+ + VR YVSCA+GCP EG + P+KVA V K+LY MGC+EISLGDTIG
Sbjct: 148 QRFDAILKAAQSANISVRGYVSCALGCPYEGKISPAKVAEVTKKLYSMGCYEISLGDTIG 207
Query: 551 IGTPGSVVPMLEAVMAAVPAEKLAVHFHDTYGQALANILVSLQMGINIVDSSVAGLGGCP 372
+GTPG + ML AVM VP LAVH HDTYGQALAN L++LQMG+++VDSSVAGLGGCP
Sbjct: 208 VGTPGIMKGMLSAVMQEVPLAALAVHCHDTYGQALANTLMALQMGVSVVDSSVAGLGGCP 267
Query: 371 YAKGVSGNVATEDVVYMLNGLGVQTNVDLGKLIAAGDFISKHLGRPNGSKAAVA 210
YA+G SGN+ATED+VYML GLG+ T V+L KL+ AG+FI + L R SK A A
Sbjct: 268 YAQGASGNLATEDLVYMLEGLGIHTGVNLQKLLEAGNFICQALNRKTSSKVAQA 321
>sp|P35914|HMGCL_HUMAN Hydroxymethylglutaryl-CoA lyase, mitochondrial OS=Homo
sapiens GN=HMGCL PE=1 SV=2
Length = 325
Score = 374 bits (958), Expect = 2e-102
Identities = 189/294 (64%), Positives = 224/294 (76%), Gaps = 1/294 (0%)
Frame = -3
Query: 1091 VPKFVKIVEVGPRDGLQNEKNIVPTSVKVELIRRLVSAGLPVVEATSFVSPKWVPQLADA 912
+PK VKIVEVGPRDGLQNEKNIV T VK++LI L AGL V+E TSFVSPKWVPQ+ D
Sbjct: 29 LPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLIDMLSEAGLSVIETTSFVSPKWVPQMGDH 88
Query: 911 KNVMDAVNTLHGAARLPVLTPNLKGFEAAVSAGAKEVAIFASASESFSLSNINCTIEESL 732
V+ + G PVLTPNLKGFEAAV+AGAKEV IF +ASE F+ NINC+IEES
Sbjct: 89 TEVLKGIQKFPG-INYPVLTPNLKGFEAAVAAGAKEVVIFGAASELFTKKNINCSIEESF 147
Query: 731 LRYRAVSTAAKEHSFPVRAYVSCAVGCPVEGAVPPSKVAHVVKELYDMGCFEISLGDTIG 552
R+ A+ AA+ + VR YVSCA+GCP EG + P+KVA V K+ Y MGC+EISLGDTIG
Sbjct: 148 QRFDAILKAAQSANISVRGYVSCALGCPYEGKISPAKVAEVTKKFYSMGCYEISLGDTIG 207
Query: 551 IGTPGSVVPMLEAVMAAVPAEKLAVHFHDTYGQALANILVSLQMGINIVDSSVAGLGGCP 372
+GTPG + ML AVM VP LAVH HDTYGQALAN L++LQMG+++VDSSVAGLGGCP
Sbjct: 208 VGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQALANTLMALQMGVSVVDSSVAGLGGCP 267
Query: 371 YAKGVSGNVATEDVVYMLNGLGVQTNVDLGKLIAAGDFISKHLGRPNGSKAAVA 210
YA+G SGN+ATED+VYML GLG+ T V+L KL+ AG+FI + L R SK A A
Sbjct: 268 YAQGASGNLATEDLVYMLEGLGIHTGVNLQKLLEAGNFICQALNRKTSSKVAQA 321
>sp|Q8HXZ6|HMGCL_MACFA Hydroxymethylglutaryl-CoA lyase, mitochondrial OS=Macaca
fascicularis GN=HMGCL PE=2 SV=1
Length = 325
Score = 373 bits (956), Expect = 3e-102
Identities = 188/294 (63%), Positives = 225/294 (76%), Gaps = 1/294 (0%)
Frame = -3
Query: 1091 VPKFVKIVEVGPRDGLQNEKNIVPTSVKVELIRRLVSAGLPVVEATSFVSPKWVPQLADA 912
+PK VKIVEVGPRDGLQNEKNIV T VK++LI L AGL V+EATSFVSPKWVPQ+AD
Sbjct: 29 LPKQVKIVEVGPRDGLQNEKNIVSTPVKIKLIDMLSEAGLSVIEATSFVSPKWVPQMADH 88
Query: 911 KNVMDAVNTLHGAARLPVLTPNLKGFEAAVSAGAKEVAIFASASESFSLSNINCTIEESL 732
V+ + G PVL PNLKGFEAAV+AGAKEV+IF +ASE F+ N+NC+IEES
Sbjct: 89 AEVLKGIQKFPGIT-YPVLIPNLKGFEAAVAAGAKEVSIFGAASELFTKKNVNCSIEESF 147
Query: 731 LRYRAVSTAAKEHSFPVRAYVSCAVGCPVEGAVPPSKVAHVVKELYDMGCFEISLGDTIG 552
R+ A+ AA+ + VR YVSC +GCP EG + P+KVA V K+ Y MGC+EISLGDTIG
Sbjct: 148 QRFDAILKAAQSANISVRGYVSCVLGCPYEGKISPAKVAEVTKKFYSMGCYEISLGDTIG 207
Query: 551 IGTPGSVVPMLEAVMAAVPAEKLAVHFHDTYGQALANILVSLQMGINIVDSSVAGLGGCP 372
+GTPG + ML AVM VP LAVH HDTYGQALAN L++LQMG+++VDSSVAGLGGCP
Sbjct: 208 VGTPGIMKDMLSAVMQEVPPAALAVHCHDTYGQALANTLMALQMGVSVVDSSVAGLGGCP 267
Query: 371 YAKGVSGNVATEDVVYMLNGLGVQTNVDLGKLIAAGDFISKHLGRPNGSKAAVA 210
YA+G SGN+ATED+VYML GLG+ T V+L KL+ AG+FI + L R SK A A
Sbjct: 268 YAQGASGNLATEDLVYMLEGLGIHTGVNLQKLLEAGNFICQALNRKTSSKVAQA 321
>sp|P13703|HMGCL_PSEMV Hydroxymethylglutaryl-CoA lyase OS=Pseudomonas mevalonii
GN=mvaB PE=3 SV=1
Length = 301
Score = 297 bits (760), Expect = 2e-079
Identities = 152/294 (51%), Positives = 196/294 (66%), Gaps = 1/294 (0%)
Frame = -3
Query: 1079 VKIVEVGPRDGLQNEKNIVPTSVKVELIRRLVSAGLPVVEATSFVSPKWVPQLADAKNVM 900
VK+ EVGPRDGLQNE+ + + +V LI L GL +EA +FVSP+WVPQ+A + V+
Sbjct: 4 VKVFEVGPRDGLQNERQPLSVAARVGLIGELAGTGLRHIEAGAFVSPRWVPQMAGSDEVL 63
Query: 899 DAVNTLHGAARLPVLTPNLKGFEAAVSAGAKEVAIFASASESFSLSNINCTIEESLLRYR 720
+ + G + L PN +GFEAA AG +EVA+FA+ASE+FS +NINC+I+ES R+
Sbjct: 64 RQLPSNDGVS-YTALVPNRQGFEAAQRAGCREVAVFAAASEAFSRNNINCSIDESFERFT 122
Query: 719 AVSTAAKEHSFPVRAYVSCAVGCPVEGAVPPSKVAHVVKELYDMGCFEISLGDTIGIGTP 540
V AA E S VR YVSC +GCP GAV P VA V + LY++GC+EISLGDTIG G P
Sbjct: 123 PVLRAANEASIRVRGYVSCVLGCPFSGAVAPEAVAKVARRLYELGCYEISLGDTIGAGRP 182
Query: 539 GSVVPMLEAVMAAVPAEKLAVHFHDTYGQALANILVSLQMGINIVDSSVAGLGGCPYAKG 360
+ E +P LA HFHDT+G A+AN+ +L G+ DSSVAGLGGCPY+ G
Sbjct: 183 DETAQLFELCARQLPVAALAGHFHDTWGMAIANVHAALAQGVRTFDSSVAGLGGCPYSPG 242
Query: 359 VSGNVATEDVVYMLNGLGVQTNVDLGKLIAAGDFISKHLGRPNGSKAAVALSHR 198
SGNVATED++Y+L+GLG T VDL + G IS LG N S+A +AL+ R
Sbjct: 243 ASGNVATEDLLYLLHGLGYSTGVDLEAVAQVGVRISAQLGTANRSRAGLALAAR 296
>sp|O34873|HMGCL_BACSU Hydroxymethylglutaryl-CoA lyase yngG OS=Bacillus subtilis
GN=yngG PE=1 SV=1
Length = 299
Score = 257 bits (654), Expect = 3e-067
Identities = 134/289 (46%), Positives = 181/289 (62%), Gaps = 1/289 (0%)
Frame = -3
Query: 1088 PKFVKIVEVGPRDGLQNEKNIVPTSVKVELIRRLVSAGLPVVEATSFVSPKWVPQLADAK 909
PK V I EVGPRDGLQNE + T K+ I +L GL +E TSFV PKW+P L DA
Sbjct: 4 PKKVTIKEVGPRDGLQNEPVWIATEDKITWINQLSRTGLSYIEITSFVHPKWIPALRDAI 63
Query: 908 NVMDAVNTLHGAARLPVLTPNLKGFEAAVSAGAKEVAIFASASESFSLSNINCTIEESLL 729
+V ++ G L PN +G E A+ G E +F SASE+ + NIN + ESL
Sbjct: 64 DVAKGIDREKGVT-YAALVPNQRGLENALEGGINEACVFMSASETHNRKNINKSTSESLH 122
Query: 728 RYRAVSTAAKEHSFPVRAYVSCAVGCPVEGAVPPSKVAHVVKELYDMGCFEISLGDTIGI 549
+ V+ A++ + RAY+S GCP E VP +V + + L++ G E+SLGDTIG
Sbjct: 123 ILKQVNNDAQKANLTTRAYLSTVFGCPYEKDVPIEQVIRLSEALFEFGISELSLGDTIGA 182
Query: 548 GTPGSVVPMLEAVMAAVPAEKLAVHFHDTYGQALANILVSLQMGINIVDSSVAGLGGCPY 369
P V +LEA++A PA ++A+HFHDT G ALAN++ +LQMGI + D S GLGGCPY
Sbjct: 183 ANPAQVETVLEALLARFPANQIALHFHDTRGTALANMVTALQMGITVFDGSAGGLGGCPY 242
Query: 368 AKGVSGNVATEDVVYMLNGLGVQTNVDLGKLIAAGDFISKHLGRPNGSK 222
A G SGN ATED+VYML + ++TNV L KL++A +I + +G+P S+
Sbjct: 243 APGSSGNAATEDIVYMLEQMDIKTNVKLEKLLSAAKWIEEKMGKPLPSR 291
Database: UniProt/SwissProt
Posted date: Sat Aug 07 14:36:18 2010
Number of letters in database: 182,829,261
Number of sequences in database: 518,415
Lambda K H
0.267 0.041 0.140
Gapped
Lambda K H
0.267 0.041 0.140
Matrix: blosum62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 136,577,310,443
Number of Sequences: 518415
Number of Extensions: 136577310443
Number of Successful Extensions: 839494199
Number of sequences better than 0.0: 0
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