BLASTX 7.6.2
Query= UN36121 /QuerySize=1037
(1036 letters)
Database: UniProt/SwissProt;
518,415 sequences; 182,829,261 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q99KH8|STK24_MOUSE Serine/threonine-protein kinase 24 OS=Mus ... 357 1e-097
sp|Q9Y6E0|STK24_HUMAN Serine/threonine-protein kinase 24 OS=Homo... 354 8e-097
sp|Q9Z2W1|STK25_MOUSE Serine/threonine-protein kinase 25 OS=Mus ... 353 1e-096
sp|Q3SWY6|STK25_BOVIN Serine/threonine-protein kinase 25 OS=Bos ... 353 2e-096
sp|O00506|STK25_HUMAN Serine/threonine-protein kinase 25 OS=Homo... 351 5e-096
sp|O61122|SVKA_DICDI Serine/threonine-protein kinase svkA OS=Dic... 351 8e-096
sp|Q9P289|MST4_HUMAN Serine/threonine-protein kinase MST4 OS=Hom... 338 4e-092
sp|Q99JT2|MST4_MOUSE Serine/threonine-protein kinase MST4 OS=Mus... 338 4e-092
sp|Q86IX1|DST1_DICDI Serine/threonine-protein kinase dst1 OS=Dic... 278 4e-074
sp|O14047|PPK11_SCHPO Serine/threonine-protein kinase ppk11 OS=S... 258 7e-068
sp|P38692|KIC1_YEAST Serine/threonine-protein kinase KIC1 OS=Sac... 255 5e-067
sp|O75011|NAK1_SCHPO Serine/threonine-protein kinase nak1 OS=Sch... 255 5e-067
sp|Q8IVH8|M4K3_HUMAN Mitogen-activated protein kinase kinase kin... 253 2e-066
sp|Q99JP0|M4K3_MOUSE Mitogen-activated protein kinase kinase kin... 253 2e-066
sp|Q924I2|M4K3_RAT Mitogen-activated protein kinase kinase kinas... 250 2e-065
sp|Q9Y4K4|M4K5_HUMAN Mitogen-activated protein kinase kinase kin... 248 6e-065
sp|Q8BPM2|M4K5_MOUSE Mitogen-activated protein kinase kinase kin... 248 8e-065
sp|Q12851|M4K2_HUMAN Mitogen-activated protein kinase kinase kin... 242 3e-063
sp|Q61161|M4K2_MOUSE Mitogen-activated protein kinase kinase kin... 242 4e-063
sp|Q92918|M4K1_HUMAN Mitogen-activated protein kinase kinase kin... 232 3e-060
>sp|Q99KH8|STK24_MOUSE Serine/threonine-protein kinase 24 OS=Mus musculus
GN=Stk24 PE=1 SV=1
Length = 431
Score = 357 bits (914), Expect = 1e-097
Identities = 174/269 (64%), Positives = 217/269 (80%), Gaps = 2/269 (0%)
Frame = -3
Query: 809 FSQVELIGRGSFGDVYKAFDSYLNKEVAIKVIDLEESEDEIEDIQKEISVLSQCRCPYIT 630
F+++E IG+GSFG+V+K D+ K VAIK+IDLEE+EDEIEDIQ+EI+VLSQC PY+T
Sbjct: 24 FTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEIEDIQQEITVLSQCDSPYVT 83
Query: 629 EYYGSYLHQTKLWIIMEYMAGGSVADLLQPGHPLDEISIACITRDLLHAVEYLHTEGKIH 450
+YYGSYL TKLWIIMEY+ GGS DLL+PG PLDEI IA I R++L ++YLH+E KIH
Sbjct: 84 KYYGSYLKDTKLWIIMEYLGGGSALDLLEPG-PLDEIQIATILREILKGLDYLHSEKKIH 142
Query: 449 RDIKAANILLSENGDVKVADFGVFAQLTRTISRRKTFVGTPFWMAPEVIQNSEGYNEKAD 270
RDIKAAN+LLSE+G+VK+ADFGV QLT T +R TFVGTPFWMAPEVI+ S Y+ KAD
Sbjct: 143 RDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQS-AYDSKAD 201
Query: 269 IWSLGITMIEMAKGEPPLADLHPMRVLFIIPRESPPQLDEHFSRPLKEFVSLCLKKAPAE 90
IWSLGIT IE+AKGEPP ++LHPM+VLF+IP+ +PP L+ ++S+PLKEFV CL K P+
Sbjct: 202 IWSLGITAIELAKGEPPHSELHPMKVLFLIPKNNPPTLEGNYSKPLKEFVEACLNKEPSF 261
Query: 89 RPSAKELFKHRFIKSARKSPKLLDRIIER 3
RP+AKEL KH+FI K L +I+R
Sbjct: 262 RPTAKELLKHKFIIRNAKKTSYLTELIDR 290
>sp|Q9Y6E0|STK24_HUMAN Serine/threonine-protein kinase 24 OS=Homo sapiens
GN=STK24 PE=1 SV=1
Length = 443
Score = 354 bits (907), Expect = 8e-097
Identities = 172/269 (63%), Positives = 216/269 (80%), Gaps = 2/269 (0%)
Frame = -3
Query: 809 FSQVELIGRGSFGDVYKAFDSYLNKEVAIKVIDLEESEDEIEDIQKEISVLSQCRCPYIT 630
F+++E IG+GSFG+V+K D+ K VAIK+IDLEE+EDEIEDIQ+EI+VLSQC PY+T
Sbjct: 36 FTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEIEDIQQEITVLSQCDSPYVT 95
Query: 629 EYYGSYLHQTKLWIIMEYMAGGSVADLLQPGHPLDEISIACITRDLLHAVEYLHTEGKIH 450
+YYGSYL TKLWIIMEY+ GGS DLL+PG PLDE IA I R++L ++YLH+E KIH
Sbjct: 96 KYYGSYLKDTKLWIIMEYLGGGSALDLLEPG-PLDETQIATILREILKGLDYLHSEKKIH 154
Query: 449 RDIKAANILLSENGDVKVADFGVFAQLTRTISRRKTFVGTPFWMAPEVIQNSEGYNEKAD 270
RDIKAAN+LLSE+G+VK+ADFGV QLT T +R TFVGTPFWMAPEVI+ S Y+ KAD
Sbjct: 155 RDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQS-AYDSKAD 213
Query: 269 IWSLGITMIEMAKGEPPLADLHPMRVLFIIPRESPPQLDEHFSRPLKEFVSLCLKKAPAE 90
IWSLGIT IE+A+GEPP ++LHPM+VLF+IP+ +PP L+ ++S+PLKEFV CL K P+
Sbjct: 214 IWSLGITAIELARGEPPHSELHPMKVLFLIPKNNPPTLEGNYSKPLKEFVEACLNKEPSF 273
Query: 89 RPSAKELFKHRFIKSARKSPKLLDRIIER 3
RP+AKEL KH+FI K L +I+R
Sbjct: 274 RPTAKELLKHKFILRNAKKTSYLTELIDR 302
>sp|Q9Z2W1|STK25_MOUSE Serine/threonine-protein kinase 25 OS=Mus musculus
GN=Stk25 PE=1 SV=1
Length = 426
Score = 353 bits (905), Expect = 1e-096
Identities = 174/269 (64%), Positives = 212/269 (78%), Gaps = 2/269 (0%)
Frame = -3
Query: 809 FSQVELIGRGSFGDVYKAFDSYLNKEVAIKVIDLEESEDEIEDIQKEISVLSQCRCPYIT 630
F++++ IG+GSFG+VYK D++ + VAIK+IDLEE+EDEIEDIQ+EI+VLSQC PYIT
Sbjct: 20 FTKLDRIGKGSFGEVYKGIDNHTKEVVAIKIIDLEEAEDEIEDIQQEITVLSQCDSPYIT 79
Query: 629 EYYGSYLHQTKLWIIMEYMAGGSVADLLQPGHPLDEISIACITRDLLHAVEYLHTEGKIH 450
Y+GSYL TKLWIIMEY+ GGS DLL+PG PL+E IA I R++L ++YLH+E KIH
Sbjct: 80 RYFGSYLKSTKLWIIMEYLGGGSALDLLKPG-PLEETYIATILREILKGLDYLHSERKIH 138
Query: 449 RDIKAANILLSENGDVKVADFGVFAQLTRTISRRKTFVGTPFWMAPEVIQNSEGYNEKAD 270
RDIKAAN+LLSE GDVK+ADFGV QLT T +R TFVGTPFWMAPEVI+ S Y+ KAD
Sbjct: 139 RDIKAANVLLSEQGDVKMADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQS-AYDFKAD 197
Query: 269 IWSLGITMIEMAKGEPPLADLHPMRVLFIIPRESPPQLDEHFSRPLKEFVSLCLKKAPAE 90
IWSLGIT IE+AKGEPP +DLHPMRVLF+IP+ +PP L+ H S+P KEFV CL K P
Sbjct: 198 IWSLGITAIELAKGEPPNSDLHPMRVLFLIPKNNPPTLEGHHSKPFKEFVEACLNKDPRF 257
Query: 89 RPSAKELFKHRFIKSARKSPKLLDRIIER 3
RP+AKEL KH+FI K L +I+R
Sbjct: 258 RPTAKELLKHKFITRYTKKTSFLTELIDR 286
>sp|Q3SWY6|STK25_BOVIN Serine/threonine-protein kinase 25 OS=Bos taurus GN=STK25
PE=2 SV=1
Length = 426
Score = 353 bits (904), Expect = 2e-096
Identities = 175/269 (65%), Positives = 211/269 (78%), Gaps = 2/269 (0%)
Frame = -3
Query: 809 FSQVELIGRGSFGDVYKAFDSYLNKEVAIKVIDLEESEDEIEDIQKEISVLSQCRCPYIT 630
F++++ IG+GSFG+VYK D+ + VAIK+IDLEE+EDEIEDIQ+EI+VLSQC PYIT
Sbjct: 20 FTKLDRIGKGSFGEVYKGIDNRTKEVVAIKIIDLEEAEDEIEDIQQEITVLSQCDSPYIT 79
Query: 629 EYYGSYLHQTKLWIIMEYMAGGSVADLLQPGHPLDEISIACITRDLLHAVEYLHTEGKIH 450
Y+GSYL TKLWIIMEY+ GGS DLL+PG PL+E IA I R++L ++YLH+E KIH
Sbjct: 80 RYFGSYLKSTKLWIIMEYLGGGSALDLLKPG-PLEETYIATILREILKGLDYLHSERKIH 138
Query: 449 RDIKAANILLSENGDVKVADFGVFAQLTRTISRRKTFVGTPFWMAPEVIQNSEGYNEKAD 270
RDIKAAN+LLSE GDVK+ADFGV QLT T +R TFVGTPFWMAPEVI+ S Y+ KAD
Sbjct: 139 RDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQS-AYDFKAD 197
Query: 269 IWSLGITMIEMAKGEPPLADLHPMRVLFIIPRESPPQLDEHFSRPLKEFVSLCLKKAPAE 90
IWSLGIT IE+AKGEPP +DLHPMRVLF+IP+ SPP L+ H S+P KEFV CL K P
Sbjct: 198 IWSLGITAIELAKGEPPNSDLHPMRVLFLIPKNSPPTLEGHHSKPFKEFVEACLNKDPRF 257
Query: 89 RPSAKELFKHRFIKSARKSPKLLDRIIER 3
RP+AKEL KH+FI K L +I+R
Sbjct: 258 RPTAKELLKHKFITRYTKKTSFLTELIDR 286
>sp|O00506|STK25_HUMAN Serine/threonine-protein kinase 25 OS=Homo sapiens
GN=STK25 PE=1 SV=1
Length = 426
Score = 351 bits (900), Expect = 5e-096
Identities = 174/269 (64%), Positives = 211/269 (78%), Gaps = 2/269 (0%)
Frame = -3
Query: 809 FSQVELIGRGSFGDVYKAFDSYLNKEVAIKVIDLEESEDEIEDIQKEISVLSQCRCPYIT 630
F++++ IG+GSFG+VYK D++ + VAIK+IDLEE+EDEIEDIQ+EI+VLSQC PYIT
Sbjct: 20 FTKLDRIGKGSFGEVYKGIDNHTKEVVAIKIIDLEEAEDEIEDIQQEITVLSQCDSPYIT 79
Query: 629 EYYGSYLHQTKLWIIMEYMAGGSVADLLQPGHPLDEISIACITRDLLHAVEYLHTEGKIH 450
Y+GSYL TKLWIIMEY+ GGS DLL+PG PL+E IA I R++L ++YLH+E KIH
Sbjct: 80 RYFGSYLKSTKLWIIMEYLGGGSALDLLKPG-PLEETYIATILREILKGLDYLHSERKIH 138
Query: 449 RDIKAANILLSENGDVKVADFGVFAQLTRTISRRKTFVGTPFWMAPEVIQNSEGYNEKAD 270
RDIKAAN+LLSE GDVK+ADFGV QLT T +R TFVGTPFWMAPEVI+ S Y+ KAD
Sbjct: 139 RDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQS-AYDFKAD 197
Query: 269 IWSLGITMIEMAKGEPPLADLHPMRVLFIIPRESPPQLDEHFSRPLKEFVSLCLKKAPAE 90
IWSLGIT IE+AKGEPP +DLHPMRVLF+IP+ SPP L+ S+P KEFV CL K P
Sbjct: 198 IWSLGITAIELAKGEPPNSDLHPMRVLFLIPKNSPPTLEGQHSKPFKEFVEACLNKDPRF 257
Query: 89 RPSAKELFKHRFIKSARKSPKLLDRIIER 3
RP+AKEL KH+FI K L +I+R
Sbjct: 258 RPTAKELLKHKFITRYTKKTSFLTELIDR 286
>sp|O61122|SVKA_DICDI Serine/threonine-protein kinase svkA OS=Dictyostelium
discoideum GN=svkA PE=1 SV=1
Length = 478
Score = 351 bits (898), Expect = 8e-096
Identities = 170/265 (64%), Positives = 218/265 (82%), Gaps = 3/265 (1%)
Frame = -3
Query: 797 ELIGRGSFGDVYKAFDSYLNKEVAIKVIDLEESEDEIEDIQKEISVLSQCRCPYITEYYG 618
E IG+GSFG+V+K + N+ +AIK IDLE++EDEIEDIQ+EI+VLSQC P++T+Y+G
Sbjct: 16 EKIGKGSFGEVFKGINKKTNETIAIKTIDLEDAEDEIEDIQQEINVLSQCESPFVTKYFG 75
Query: 617 SYLHQTKLWIIMEYMAGGSVADLLQPGHPLDEISIACITRDLLHAVEYLHTEGKIHRDIK 438
S+L +KLWIIMEY+AGGSV DL++PG P DE IA I R+LL +EYLH+EGKIHRDIK
Sbjct: 76 SFLKGSKLWIIMEYLAGGSVLDLMKPG-PFDEGYIAIILRELLKGLEYLHSEGKIHRDIK 134
Query: 437 AANILLSENGDVKVADFGVFAQLTRTISRRKTFVGTPFWMAPEVIQNSEGYNEKADIWSL 258
AAN+LLS +GDVK+ADFGV QLT +++R TFVGTPFWMAPEVI+ + GY+ KADIWS+
Sbjct: 135 AANVLLSASGDVKLADFGVSGQLTDQMTKRNTFVGTPFWMAPEVIKQT-GYDSKADIWSM 193
Query: 257 GITMIEMAKGEPPLADLHPMRVLFIIPRESPPQLDEHFSRPLKEFVSLCLKKAPAERPSA 78
GIT +EMAKGEPP ADLHPMR LF+IP++ PP L+ +FS+ KEF +LCL K P +RP+A
Sbjct: 194 GITALEMAKGEPPRADLHPMRALFLIPKDPPPTLEGNFSKGFKEFCALCLNKDPNQRPTA 253
Query: 77 KELFKHRFIKSARKSPKLLDRIIER 3
K+L KH+FIK+A+K+ L D +IER
Sbjct: 254 KDLLKHKFIKAAKKTSSLTD-LIER 277
>sp|Q9P289|MST4_HUMAN Serine/threonine-protein kinase MST4 OS=Homo sapiens
GN=MST4 PE=1 SV=2
Length = 416
Score = 338 bits (866), Expect = 4e-092
Identities = 166/269 (61%), Positives = 208/269 (77%), Gaps = 2/269 (0%)
Frame = -3
Query: 809 FSQVELIGRGSFGDVYKAFDSYLNKEVAIKVIDLEESEDEIEDIQKEISVLSQCRCPYIT 630
F+++E IG+GSFG+V+K D+ + VAIK+IDLEE+EDEIEDIQ+EI+VLSQC Y+T
Sbjct: 24 FTKLERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEIEDIQQEITVLSQCDSSYVT 83
Query: 629 EYYGSYLHQTKLWIIMEYMAGGSVADLLQPGHPLDEISIACITRDLLHAVEYLHTEGKIH 450
+YYGSYL +KLWIIMEY+ GGS DLL+ G P DE IA + +++L ++YLH+E KIH
Sbjct: 84 KYYGSYLKGSKLWIIMEYLGGGSALDLLRAG-PFDEFQIATMLKEILKGLDYLHSEKKIH 142
Query: 449 RDIKAANILLSENGDVKVADFGVFAQLTRTISRRKTFVGTPFWMAPEVIQNSEGYNEKAD 270
RDIKAAN+LLSE GDVK+ADFGV QLT T +R TFVGTPFWMAPEVIQ S Y+ KAD
Sbjct: 143 RDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIQQS-AYDSKAD 201
Query: 269 IWSLGITMIEMAKGEPPLADLHPMRVLFIIPRESPPQLDEHFSRPLKEFVSLCLKKAPAE 90
IWSLGIT IE+AKGEPP +D+HPMRVLF+IP+ +PP L F++ KEF+ CL K P+
Sbjct: 202 IWSLGITAIELAKGEPPNSDMHPMRVLFLIPKNNPPTLVGDFTKSFKEFIDACLNKDPSF 261
Query: 89 RPSAKELFKHRFIKSARKSPKLLDRIIER 3
RP+AKEL KH+FI K L +I+R
Sbjct: 262 RPTAKELLKHKFIVKNSKKTSYLTELIDR 290
>sp|Q99JT2|MST4_MOUSE Serine/threonine-protein kinase MST4 OS=Mus musculus
GN=Mst4 PE=2 SV=1
Length = 416
Score = 338 bits (866), Expect = 4e-092
Identities = 166/269 (61%), Positives = 208/269 (77%), Gaps = 2/269 (0%)
Frame = -3
Query: 809 FSQVELIGRGSFGDVYKAFDSYLNKEVAIKVIDLEESEDEIEDIQKEISVLSQCRCPYIT 630
F+++E IG+GSFG+V+K D+ + VAIK+IDLEE+EDEIEDIQ+EI+VLSQC Y+T
Sbjct: 24 FTKLERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEIEDIQQEITVLSQCDSSYVT 83
Query: 629 EYYGSYLHQTKLWIIMEYMAGGSVADLLQPGHPLDEISIACITRDLLHAVEYLHTEGKIH 450
+YYGSYL +KLWIIMEY+ GGS DLL+ G P DE IA + +++L ++YLH+E KIH
Sbjct: 84 KYYGSYLKGSKLWIIMEYLGGGSALDLLRAG-PFDEFQIATMLKEILKGLDYLHSEKKIH 142
Query: 449 RDIKAANILLSENGDVKVADFGVFAQLTRTISRRKTFVGTPFWMAPEVIQNSEGYNEKAD 270
RDIKAAN+LLSE GDVK+ADFGV QLT T +R TFVGTPFWMAPEVIQ S Y+ KAD
Sbjct: 143 RDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIQQS-AYDSKAD 201
Query: 269 IWSLGITMIEMAKGEPPLADLHPMRVLFIIPRESPPQLDEHFSRPLKEFVSLCLKKAPAE 90
IWSLGIT IE+AKGEPP +D+HPMRVLF+IP+ +PP L F++ KEF+ CL K P+
Sbjct: 202 IWSLGITAIELAKGEPPNSDMHPMRVLFLIPKNNPPTLIGDFTKSFKEFIDACLNKDPSF 261
Query: 89 RPSAKELFKHRFIKSARKSPKLLDRIIER 3
RP+AKEL KH+FI K L +I+R
Sbjct: 262 RPTAKELLKHKFIVKNSKKTSYLTELIDR 290
>sp|Q86IX1|DST1_DICDI Serine/threonine-protein kinase dst1 OS=Dictyostelium
discoideum GN=dst1 PE=3 SV=1
Length = 737
Score = 278 bits (711), Expect = 4e-074
Identities = 143/266 (53%), Positives = 191/266 (71%), Gaps = 5/266 (1%)
Frame = -3
Query: 797 ELIGRGSFGDVYKAFDSYLNKEVAIKVIDLEESEDEIEDIQKEISVLSQCRCPYITEYYG 618
E +G+GSFG V+KA K VAIK+I L++ E I+D++KEIS+L++C P I +Y+G
Sbjct: 33 ERLGKGSFGQVFKAVHFANGKVVAIKIISLDDQE-AIKDVRKEISILAECNYPNIVQYFG 91
Query: 617 SYLHQTKLWIIMEYMAGGSVADLLQPGHPLDEISIACITRDLLHAVEYLHTEGKIHRDIK 438
SY +LWI+MEY GGSV+DLLQ + E IA I R+ L + YLH KIHRDIK
Sbjct: 92 SYFKDHQLWIVMEYCGGGSVSDLLQVIDTISEDEIALICREALKGLNYLHEFKKIHRDIK 151
Query: 437 AANILLSENGDVKVADFGVFAQLTRTISRRKTFVGTPFWMAPEVIQNSEGYNEKADIWSL 258
NILL++ G+VK+ADFGV AQL T S+R TFVGTP+WMAPEVIQ ++ Y+ KAD+WSL
Sbjct: 152 GGNILLNDRGEVKLADFGVSAQLFNTFSKRNTFVGTPYWMAPEVIQENK-YDGKADVWSL 210
Query: 257 GITMIEMAKGEPPLADLHPMRVLFIIPRESPPQLDEH--FSRPLKEFVSLCLKKAPAERP 84
GIT IEMA+G PP +++HPMRV+F+IPRE P L + +S ++F+S CL K PAERP
Sbjct: 211 GITAIEMAEGLPPNSNVHPMRVIFMIPREESPALTDKSIWSDKFQDFISKCLTKDPAERP 270
Query: 83 SAKELFKHRFIKSARKSPKLLDRIIE 6
+AKEL H FI++ +K +L ++E
Sbjct: 271 TAKELLNHEFIQT-KKPLSILSDLVE 295
>sp|O14047|PPK11_SCHPO Serine/threonine-protein kinase ppk11
OS=Schizosaccharomyces pombe GN=ppk11 PE=2 SV=1
Length = 312
Score = 258 bits (657), Expect = 7e-068
Identities = 132/256 (51%), Positives = 179/256 (69%), Gaps = 2/256 (0%)
Frame = -3
Query: 812 RFSQVELIGRGSFGDVYKAFDSYLNKEVAIKVIDLEESEDEIEDIQKEISVLSQCRCPYI 633
++ ++LIG+GSFG V++A D +K VA+KV+DL+ ++D+IE + +EI+ L +I
Sbjct: 5 QYRDLQLIGQGSFGSVFRAQDVESSKIVALKVVDLDATKDQIETLTQEINFLIDLNSVHI 64
Query: 632 TEYYGSYLHQTKLWIIMEYMAGGSVADLLQPGHPLDEISIACITRDLLHAVEYLHTEGKI 453
T+YY S++ +LWI MEY GGS DLL+ E IA + R +L A+ YLH +GK+
Sbjct: 65 TKYYASFVDGFRLWITMEYCDGGSCLDLLKLSGTFSERVIAEVMRQVLEALVYLHGQGKM 124
Query: 452 HRDIKAANILLSENGDVKVADFGVFAQLTRTISRRKTFVGTPFWMAPEVIQNSEGYNEKA 273
HRDIKAANIL ++G VK+ADFGV QL + FVGTPFWMAPEV++ + GYN KA
Sbjct: 125 HRDIKAANILTMKDGLVKLADFGVSGQLESLRDKNDDFVGTPFWMAPEVVKQT-GYNYKA 183
Query: 272 DIWSLGITMIEMAKGEPPLADLHPMRVLFIIPRESPPQLD-EHFSRPLKEFVSLCLKKAP 96
DIWSLGIT E+A GEPP + +HPM+VL +IP+ SPP L+ FSR +FVS CLKK P
Sbjct: 184 DIWSLGITAYELATGEPPYSGIHPMKVLLLIPKHSPPSLERSKFSRAFCDFVSNCLKKNP 243
Query: 95 AERPSAKELFKHRFIK 48
+R +A+ L KH+FIK
Sbjct: 244 KDRATAEYLSKHKFIK 259
>sp|P38692|KIC1_YEAST Serine/threonine-protein kinase KIC1 OS=Saccharomyces
cerevisiae GN=KIC1 PE=1 SV=1
Length = 1080
Score = 255 bits (650), Expect = 5e-067
Identities = 129/262 (49%), Positives = 178/262 (67%), Gaps = 3/262 (1%)
Frame = -3
Query: 809 FSQVELIGRGSFGDVYKAFDSYLNKEVAIKVIDLEESEDEIEDIQKEISVLSQCR-CPYI 633
F + E+IGRG FG VYK ++ + AIKV++L+ DE+ED+Q+EI L+ + I
Sbjct: 23 FKRTEVIGRGKFGVVYKGYNVKTGRVYAIKVLNLDSDSDEVEDVQREIQFLASLKQISNI 82
Query: 632 TEYYGSYLHQTKLWIIMEYMAGGSVADLLQPGHPLDEISIACITRDLLHAVEYLHTEGKI 453
T YYGSYL T LWIIME+ AGGS+ LL+PG +DE I I R+LL A++ +H + I
Sbjct: 83 TRYYGSYLKDTSLWIIMEHCAGGSLRSLLRPG-KIDEKYIGVIMRELLVALKCIHKDNVI 141
Query: 452 HRDIKAANILLSENGDVKVADFGVFAQLTRTISRRKTFVGTPFWMAPEVIQNSEGYNEKA 273
HRDIKAAN+L++ G+VK+ DFGV AQ+ +T RR+T GTP+WMAPEVI Y+ K
Sbjct: 142 HRDIKAANVLITNEGNVKLCDFGVAAQVNQTSLRRQTMAGTPYWMAPEVIMEGVYYDTKV 201
Query: 272 DIWSLGITMIEMAKGEPPLADLHPMRVLFIIPRESPPQL-DEHFSRPLKEFVSLCLKKAP 96
DIWSLGIT E+A G PP D+ +R + +I + PP+L D +S LKEF++LCL + P
Sbjct: 202 DIWSLGITTYEIATGNPPYCDVEALRAMQLIIKSKPPRLEDRSYSTSLKEFIALCLDEDP 261
Query: 95 AERPSAKELFKHRFIKSARKSP 30
ER SA +L K +FI++ + +P
Sbjct: 262 KERLSADDLLKSKFIRAHKATP 283
>sp|O75011|NAK1_SCHPO Serine/threonine-protein kinase nak1
OS=Schizosaccharomyces pombe GN=nak1 PE=1 SV=1
Length = 652
Score = 255 bits (650), Expect = 5e-067
Identities = 131/277 (47%), Positives = 190/277 (68%), Gaps = 5/277 (1%)
Frame = -3
Query: 821 AGARFSQVELIGRGSFGDVYKAFDSYLNKEVAIKVIDLEESEDEIEDIQKEISVLSQCR- 645
A + ++++EL+GRGS+G VY+ + + VAIK+++L+ EDE+ DIQKE++VLS+ +
Sbjct: 6 ASSPYTKLELVGRGSYGAVYRGICNLTKETVAIKILNLDTDEDEVSDIQKEVAVLSELKQ 65
Query: 644 --CPYITEYYGSYLHQTKLWIIMEYMAGGSVADLLQPGHPLDEISIACITRDLLHAVEYL 471
I +Y+GSYL T LWIIM+Y GGSV L++ G P+ E I+ I R+ L A++++
Sbjct: 66 SDVENIIKYHGSYLVGTNLWIIMDYCHGGSVRTLMEAG-PISEPCISLILRETLQALKFI 124
Query: 470 HTEGKIHRDIKAANILLSENGDVKVADFGVFAQLTRTISRRKTFVGTPFWMAPEVIQNSE 291
H G IHRDIKAANIL+S +G+VK+ DFGV A+L +R TF+GTP+WMAPEVI++ +
Sbjct: 125 HHAGIIHRDIKAANILVSMSGNVKLCDFGVAAELNINRRKRITFIGTPYWMAPEVIRDGQ 184
Query: 290 GYNEKADIWSLGITMIEMAKGEPPLADLHPMRVLFIIPRESPPQLDEHFSRPLKEFVSLC 111
YN ADIWSLGIT E+A G PP A P R +++I +PP+L+ +FS LKEF++ C
Sbjct: 185 EYNVMADIWSLGITAYEIATGSPPHAKEDPFRAVYLIAHTAPPRLNGNFSALLKEFIASC 244
Query: 110 LKKAPAERPSAKELFKHRFIKS-ARKSPKLLDRIIER 3
L+ P R + EL K +FIK +R S L +++R
Sbjct: 245 LQDVPQRRLDSSELLKSKFIKQYSRMSISELTNVVKR 281
>sp|Q8IVH8|M4K3_HUMAN Mitogen-activated protein kinase kinase kinase kinase 3
OS=Homo sapiens GN=MAP4K3 PE=1 SV=1
Length = 894
Score = 253 bits (644), Expect = 2e-066
Identities = 124/259 (47%), Positives = 181/259 (69%), Gaps = 7/259 (2%)
Frame = -3
Query: 809 FSQVELIGRGSFGDVYKAFDSYLNKEVAIKVIDLEESEDEIEDIQKEISVLSQCRCPYIT 630
F ++ IG G++GDVYKA + + AIKVI LE ED +Q+EI ++ C+ P I
Sbjct: 16 FELIQRIGSGTYGDVYKARNVNTGELAAIKVIKLEPGED-FAVVQQEIIMMKDCKHPNIV 74
Query: 629 EYYGSYLHQTKLWIIMEYMAGGSVADLLQPGHPLDEISIACITRDLLHAVEYLHTEGKIH 450
Y+GSYL + KLWI ME+ GGS+ D+ PL E+ IA ++R+ L + YLH++GK+H
Sbjct: 75 AYFGSYLRRDKLWICMEFCGGGSLQDIYHVTGPLSELQIAYVSRETLQGLYYLHSKGKMH 134
Query: 449 RDIKAANILLSENGDVKVADFGVFAQLTRTISRRKTFVGTPFWMAPEV--IQNSEGYNEK 276
RDIK ANILL++NG VK+ADFGV AQ+T TI++RK+F+GTP+WMAPEV ++ GYN+
Sbjct: 135 RDIKGANILLTDNGHVKLADFGVSAQITATIAKRKSFIGTPYWMAPEVAAVERKGGYNQL 194
Query: 275 ADIWSLGITMIEMAKGEPPLADLHPMRVLFIIPRES--PPQLDE--HFSRPLKEFVSLCL 108
D+W++GIT IE+A+ +PP+ DLHPMR LF++ + + PP+L + +S FV + L
Sbjct: 195 CDLWAVGITAIELAELQPPMFDLHPMRALFLMTKSNFQPPKLKDKMKWSNSFHHFVKMAL 254
Query: 107 KKAPAERPSAKELFKHRFI 51
K P +RP+A++L +H F+
Sbjct: 255 TKNPKKRPTAEKLLQHPFV 273
>sp|Q99JP0|M4K3_MOUSE Mitogen-activated protein kinase kinase kinase kinase 3
OS=Mus musculus GN=Map4k3 PE=2 SV=3
Length = 894
Score = 253 bits (644), Expect = 2e-066
Identities = 124/259 (47%), Positives = 181/259 (69%), Gaps = 7/259 (2%)
Frame = -3
Query: 809 FSQVELIGRGSFGDVYKAFDSYLNKEVAIKVIDLEESEDEIEDIQKEISVLSQCRCPYIT 630
F ++ IG G++GDVYKA + + AIKVI LE ED +Q+EI ++ C+ P I
Sbjct: 16 FELIQRIGSGTYGDVYKARNVNTGELAAIKVIKLEPGED-FAVVQQEIIMMKDCKHPNIV 74
Query: 629 EYYGSYLHQTKLWIIMEYMAGGSVADLLQPGHPLDEISIACITRDLLHAVEYLHTEGKIH 450
Y+GSYL + KLWI ME+ GGS+ D+ PL E+ IA ++R+ L + YLH++GK+H
Sbjct: 75 AYFGSYLRRDKLWICMEFCGGGSLQDIYHVTGPLSELQIAYVSRETLQGLYYLHSKGKMH 134
Query: 449 RDIKAANILLSENGDVKVADFGVFAQLTRTISRRKTFVGTPFWMAPEV--IQNSEGYNEK 276
RDIK ANILL++NG VK+ADFGV AQ+T TI++RK+F+GTP+WMAPEV ++ GYN+
Sbjct: 135 RDIKGANILLTDNGHVKLADFGVSAQITATIAKRKSFIGTPYWMAPEVAAVERKGGYNQL 194
Query: 275 ADIWSLGITMIEMAKGEPPLADLHPMRVLFIIPRES--PPQLDE--HFSRPLKEFVSLCL 108
D+W++GIT IE+A+ +PP+ DLHPMR LF++ + + PP+L + +S FV + L
Sbjct: 195 CDLWAVGITAIELAELQPPMFDLHPMRALFLMTKSNFQPPKLKDKLKWSNSFHHFVKMAL 254
Query: 107 KKAPAERPSAKELFKHRFI 51
K P +RP+A++L +H F+
Sbjct: 255 TKNPKKRPNAEKLLQHPFV 273
>sp|Q924I2|M4K3_RAT Mitogen-activated protein kinase kinase kinase kinase 3
OS=Rattus norvegicus GN=Map4k3 PE=1 SV=2
Length = 873
Score = 250 bits (636), Expect = 2e-065
Identities = 123/259 (47%), Positives = 180/259 (69%), Gaps = 7/259 (2%)
Frame = -3
Query: 809 FSQVELIGRGSFGDVYKAFDSYLNKEVAIKVIDLEESEDEIEDIQKEISVLSQCRCPYIT 630
F ++ IG G++GDVYKA + + AIKVI LE ED +Q+EI ++ C+ I
Sbjct: 16 FELIQRIGSGTYGDVYKARNVNTGELAAIKVIKLEPGED-FAVVQQEIIMMKDCKHANIV 74
Query: 629 EYYGSYLHQTKLWIIMEYMAGGSVADLLQPGHPLDEISIACITRDLLHAVEYLHTEGKIH 450
Y+GSYL + KLWI ME+ GGS+ D+ PL E+ IA ++R+ L + YLH++GK+H
Sbjct: 75 AYFGSYLRRDKLWICMEFCGGGSLQDIYHVTGPLSELQIAYVSRETLQGLYYLHSKGKMH 134
Query: 449 RDIKAANILLSENGDVKVADFGVFAQLTRTISRRKTFVGTPFWMAPEV--IQNSEGYNEK 276
RDIK ANILL++NG VK+ADFGV AQ+T TI++RK+F+GTP+WMAPEV ++ GYN+
Sbjct: 135 RDIKGANILLTDNGHVKLADFGVSAQITATIAKRKSFIGTPYWMAPEVAAVERKGGYNQL 194
Query: 275 ADIWSLGITMIEMAKGEPPLADLHPMRVLFIIPRES--PPQLDE--HFSRPLKEFVSLCL 108
D+W++GIT IE+A+ +PP+ DLHPMR LF++ + + PP+L + +S FV + L
Sbjct: 195 CDLWAVGITAIELAELQPPMFDLHPMRALFLMTKSNFQPPKLKDKLKWSNSFHHFVKMAL 254
Query: 107 KKAPAERPSAKELFKHRFI 51
K P +RP+A++L +H F+
Sbjct: 255 TKNPKKRPTAEKLLQHPFV 273
>sp|Q9Y4K4|M4K5_HUMAN Mitogen-activated protein kinase kinase kinase kinase 5
OS=Homo sapiens GN=MAP4K5 PE=1 SV=1
Length = 846
Score = 248 bits (632), Expect = 6e-065
Identities = 121/259 (46%), Positives = 180/259 (69%), Gaps = 7/259 (2%)
Frame = -3
Query: 809 FSQVELIGRGSFGDVYKAFDSYLNKEVAIKVIDLEESEDEIEDIQKEISVLSQCRCPYIT 630
+ V+ +G G++GDVYKA + + + A+K+I LE D+ IQ+EI ++ +C+ I
Sbjct: 20 YELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPG-DDFSLIQQEIFMVKECKHCNIV 78
Query: 629 EYYGSYLHQTKLWIIMEYMAGGSVADLLQPGHPLDEISIACITRDLLHAVEYLHTEGKIH 450
Y+GSYL + KLWI MEY GGS+ D+ PL E+ IA + R+ L + YLHT+GK+H
Sbjct: 79 AYFGSYLSREKLWICMEYCGGGSLQDIYHVTGPLSELQIAYVCRETLQGLAYLHTKGKMH 138
Query: 449 RDIKAANILLSENGDVKVADFGVFAQLTRTISRRKTFVGTPFWMAPEV--IQNSEGYNEK 276
RDIK ANILL+++GDVK+ADFGV A++T TI++RK+F+GTP+WMAPEV ++ + GYN+
Sbjct: 139 RDIKGANILLTDHGDVKLADFGVAAKITATIAKRKSFIGTPYWMAPEVAAVEKNGGYNQL 198
Query: 275 ADIWSLGITMIEMAKGEPPLADLHPMRVLFIIPRES--PPQLDE--HFSRPLKEFVSLCL 108
DIW++GIT IE+ + +PP+ DLHPMR LF++ + + PP+L + +S FV + L
Sbjct: 199 CDIWAVGITAIELGELQPPMFDLHPMRALFLMSKSNFQPPKLKDKTKWSSTFHNFVKIAL 258
Query: 107 KKAPAERPSAKELFKHRFI 51
K P +RP+A+ L H F+
Sbjct: 259 TKNPKKRPTAERLLTHTFV 277
>sp|Q8BPM2|M4K5_MOUSE Mitogen-activated protein kinase kinase kinase kinase 5
OS=Mus musculus GN=Map4k5 PE=2 SV=2
Length = 847
Score = 248 bits (631), Expect = 8e-065
Identities = 121/259 (46%), Positives = 180/259 (69%), Gaps = 7/259 (2%)
Frame = -3
Query: 809 FSQVELIGRGSFGDVYKAFDSYLNKEVAIKVIDLEESEDEIEDIQKEISVLSQCRCPYIT 630
+ V+ +G G++GDVYKA + + + A+K+I LE D+ IQ+EI ++ +C+ I
Sbjct: 20 YELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPG-DDFSLIQQEIFMVKECKHCNIV 78
Query: 629 EYYGSYLHQTKLWIIMEYMAGGSVADLLQPGHPLDEISIACITRDLLHAVEYLHTEGKIH 450
Y+GSYL + KLWI MEY GGS+ D+ PL E+ IA + R+ L + YLHT+GK+H
Sbjct: 79 AYFGSYLSREKLWICMEYCGGGSLQDIYHVTGPLSEMQIAYVCRETLQGLAYLHTKGKMH 138
Query: 449 RDIKAANILLSENGDVKVADFGVFAQLTRTISRRKTFVGTPFWMAPEV--IQNSEGYNEK 276
RDIK ANILL+++GDVK+ADFGV A++T TI++RK+F+GTP+WMAPEV ++ + GYN+
Sbjct: 139 RDIKGANILLTDHGDVKLADFGVAAKITATIAKRKSFIGTPYWMAPEVAAVEKNGGYNQL 198
Query: 275 ADIWSLGITMIEMAKGEPPLADLHPMRVLFIIPRES--PPQLDE--HFSRPLKEFVSLCL 108
DIW++GIT IE+ + +PP+ DLHPMR LF++ + + PP+L + +S FV + L
Sbjct: 199 CDIWAVGITAIELGELQPPMFDLHPMRALFLMSKSNFQPPKLKDKTKWSSTFHNFVKIAL 258
Query: 107 KKAPAERPSAKELFKHRFI 51
K P +RP+A+ L H F+
Sbjct: 259 TKNPKKRPTAERLLTHTFV 277
>sp|Q12851|M4K2_HUMAN Mitogen-activated protein kinase kinase kinase kinase 2
OS=Homo sapiens GN=MAP4K2 PE=1 SV=2
Length = 820
Score = 242 bits (617), Expect = 3e-063
Identities = 115/259 (44%), Positives = 179/259 (69%), Gaps = 7/259 (2%)
Frame = -3
Query: 812 RFSQVELIGRGSFGDVYKAFDSYLNKEVAIKVIDLEESEDEIEDIQKEISVLSQCRCPYI 633
RF ++ +G G++GDVYKA D+ ++ A+K++ L+ D+I +Q+EI++L +CR P +
Sbjct: 15 RFELLQRVGAGTYGDVYKARDTVTSELAAVKIVKLDPG-DDISSLQQEITILRECRHPNV 73
Query: 632 TEYYGSYLHQTKLWIIMEYMAGGSVADLLQPGHPLDEISIACITRDLLHAVEYLHTEGKI 453
Y GSYL +LWI ME+ GGS+ ++ PL+E IA + R+ L + +LH++GKI
Sbjct: 74 VAYIGSYLRNDRLWICMEFCGGGSLQEIYHATGPLEERQIAYVCREALKGLHHLHSQGKI 133
Query: 452 HRDIKAANILLSENGDVKVADFGVFAQLTRTISRRKTFVGTPFWMAPEV--IQNSEGYNE 279
HRDIK AN+LL+ GDVK+ADFGV +LT ++++R++F+GTP+WMAPEV ++ GYNE
Sbjct: 134 HRDIKGANLLLTLQGDVKLADFGVSGELTASVAKRRSFIGTPYWMAPEVAAVERKGGYNE 193
Query: 278 KADIWSLGITMIEMAKGEPPLADLHPMRVLFIIPRES--PPQLDE--HFSRPLKEFVSLC 111
D+W+LGIT IE+ + +PPL LHPMR L ++ + S PP+L + +++ F+ L
Sbjct: 194 LCDVWALGITAIELGELQPPLFHLHPMRALMLMSKSSFQPPKLRDKTRWTQNFHHFLKLA 253
Query: 110 LKKAPAERPSAKELFKHRF 54
L K P +RP+A++L +H F
Sbjct: 254 LTKNPKKRPTAEKLLQHPF 272
>sp|Q61161|M4K2_MOUSE Mitogen-activated protein kinase kinase kinase kinase 2
OS=Mus musculus GN=Map4k2 PE=1 SV=1
Length = 821
Score = 242 bits (616), Expect = 4e-063
Identities = 115/259 (44%), Positives = 178/259 (68%), Gaps = 7/259 (2%)
Frame = -3
Query: 812 RFSQVELIGRGSFGDVYKAFDSYLNKEVAIKVIDLEESEDEIEDIQKEISVLSQCRCPYI 633
RF ++ +G G++GDVYKA D+ ++ A+K++ L+ D+I +Q+EI++L +CR P +
Sbjct: 15 RFELLQRVGAGTYGDVYKARDTVTSELAAVKIVKLDPG-DDISSLQQEITILRECRHPNV 73
Query: 632 TEYYGSYLHQTKLWIIMEYMAGGSVADLLQPGHPLDEISIACITRDLLHAVEYLHTEGKI 453
Y GSYL +LWI ME+ GGS+ ++ PL+E IA + R+ L + +LH++GKI
Sbjct: 74 VAYIGSYLRNDRLWICMEFCGGGSLQEIYHATGPLEERQIAYVCREALKGLHHLHSQGKI 133
Query: 452 HRDIKAANILLSENGDVKVADFGVFAQLTRTISRRKTFVGTPFWMAPEV--IQNSEGYNE 279
HRDIK AN+LL+ GDVK+ADFGV +LT ++++R++F+GTP+WMAPEV ++ GYNE
Sbjct: 134 HRDIKGANLLLTLQGDVKLADFGVSGELTASVAKRRSFIGTPYWMAPEVAAVERKGGYNE 193
Query: 278 KADIWSLGITMIEMAKGEPPLADLHPMRVLFIIPRES--PPQLDE--HFSRPLKEFVSLC 111
D+W+LGIT IE+ + +PPL LHPMR L ++ + S PP+L + +++ F+ L
Sbjct: 194 LCDVWALGITAIELGELQPPLFHLHPMRALMLMSKSSFQPPKLRDKTRWTQNFHHFLKLA 253
Query: 110 LKKAPAERPSAKELFKHRF 54
L K P +RP+A+ L +H F
Sbjct: 254 LTKNPKKRPTAERLLQHPF 272
>sp|Q92918|M4K1_HUMAN Mitogen-activated protein kinase kinase kinase kinase 1
OS=Homo sapiens GN=MAP4K1 PE=1 SV=1
Length = 833
Score = 232 bits (591), Expect = 3e-060
Identities = 114/259 (44%), Positives = 175/259 (67%), Gaps = 7/259 (2%)
Frame = -3
Query: 809 FSQVELIGRGSFGDVYKAFDSYLNKEVAIKVIDLEESEDEIEDIQKEISVLSQCRCPYIT 630
+ ++ +G G++G+V+KA D VA+K++ + E +D++ +QKEI +L CR I
Sbjct: 17 YDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKM-EPDDDVSTLQKEILILKTCRHANIV 75
Query: 629 EYYGSYLHQTKLWIIMEYMAGGSVADLLQPGHPLDEISIACITRDLLHAVEYLHTEGKIH 450
Y+GSYL KLWI ME+ GS+ D+ Q L E+ I+ + R++L + YLH++ KIH
Sbjct: 76 AYHGSYLWLQKLWICMEFCGAGSLQDIYQVTGSLSELQISYVCREVLQGLAYLHSQKKIH 135
Query: 449 RDIKAANILLSENGDVKVADFGVFAQLTRTISRRKTFVGTPFWMAPEV--IQNSEGYNEK 276
RDIK ANIL+++ G+V++ADFG+ AQ+ T++RR +F+GTP+WMAPEV + GYNE
Sbjct: 136 RDIKGANILINDAGEVRLADFGISAQIGATLARRLSFIGTPYWMAPEVAAVALKGGYNEL 195
Query: 275 ADIWSLGITMIEMAKGEPPLADLHPMRVLFIIPRE--SPPQLDE--HFSRPLKEFVSLCL 108
DIWSLGIT IE+A+ +PPL D+HP+RVLF++ + PP+L E +S F+ + L
Sbjct: 196 CDIWSLGITAIELAELQPPLFDVHPLRVLFLMTKSGYQPPRLKEKGKWSAAFHNFIKVTL 255
Query: 107 KKAPAERPSAKELFKHRFI 51
K+P +RPSA ++ H+ +
Sbjct: 256 TKSPKKRPSATKMLSHQLV 274
Database: UniProt/SwissProt
Posted date: Sat Aug 07 14:36:18 2010
Number of letters in database: 182,829,261
Number of sequences in database: 518,415
Lambda K H
0.267 0.041 0.140
Gapped
Lambda K H
0.267 0.041 0.140
Matrix: blosum62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 142,442,557,381
Number of Sequences: 518415
Number of Extensions: 142442557381
Number of Successful Extensions: 892588021
Number of sequences better than 0.0: 0
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