BLASTX 7.6.2
Query= UN38999 /QuerySize=1177
(1176 letters)
Database: UniProt/SwissProt;
518,415 sequences; 182,829,261 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|O35075|DSCR3_MOUSE Down syndrome critical region protein 3 ho... 213 3e-054
sp|O14972|DSCR3_HUMAN Down syndrome critical region protein 3 OS... 211 7e-054
sp|Q5RF33|DSCR3_PONAB Down syndrome critical region protein 3 ho... 210 3e-053
sp|Q54DI8|DSCR3_DICDI Down syndrome critical region protein 3 ho... 177 2e-043
>sp|O35075|DSCR3_MOUSE Down syndrome critical region protein 3 homolog OS=Mus
musculus GN=Dscr3 PE=2 SV=1
Length = 297
Score = 213 bits (541), Expect = 3e-054
Identities = 114/284 (40%), Positives = 172/284 (60%), Gaps = 10/284 (3%)
Frame = -1
Query: 1140 TTVTVKLSRSNRIYRSSEAVEGKIVIKSPNSISHQAIRLSVNGSVNLQVRGGSAGVIESF 961
TT+ +K+ R+N++Y + E + G +VI S +S+ HQ + L++ G+VNLQ+ S GV E+F
Sbjct: 3 TTLDIKIKRANKVYHAGEMLSGVVVISSKDSVQHQGVSLTMEGTVNLQLSAKSVGVFEAF 62
Query: 960 YGVIKPIQILKKTIEVRSSGRIPPGTTEIPFSVNLREPAESIAEKFYETFHGTNINIQYL 781
Y +KPIQI+ TI+V G+IP G TE+PF L + YET+HG +NIQY
Sbjct: 63 YNSVKPIQIINSTIDVLKPGKIPSGKTEVPFEFPLLVKGSKV---LYETYHGVFVNIQYT 119
Query: 780 LTADIPRGYLHKPLSATVEFIIESGRVDLPER-PLPPEMVIFYITQDTQRHPLLPDIKTG 604
L D+ R L K L+ T EFI+ S P++ L P V F IT +T ++ +
Sbjct: 120 LRCDMRRSLLAKDLTKTCEFIVHSA----PQKGKLTPSPVDFTITPETLQN-VKERASLP 174
Query: 603 GFRVTGKL-ATQCSLQDPLSGELTVEASSVPITSIDIHLLRVESIIVGERIVTETSLIQS 427
F + G L +T C++ PL+GEL VE S I SI++ L+RVE+ E + + IQ+
Sbjct: 175 KFFIRGHLNSTNCAITQPLTGELVVEHSDAAIRSIELQLVRVETCGCAEGYARDATEIQN 234
Query: 426 TQIADGDVCRKMTLPIYVLLPRLLMCPSIFAGPFSVEFKVCITI 295
QIADGD+CR +++P+Y++ PRL CP++ F VEF+V + +
Sbjct: 235 IQIADGDICRNLSVPLYMVFPRLFTCPTLETTNFKVEFEVNVVV 278
>sp|O14972|DSCR3_HUMAN Down syndrome critical region protein 3 OS=Homo sapiens
GN=DSCR3 PE=1 SV=1
Length = 297
Score = 211 bits (537), Expect = 7e-054
Identities = 115/284 (40%), Positives = 167/284 (58%), Gaps = 10/284 (3%)
Frame = -1
Query: 1140 TTVTVKLSRSNRIYRSSEAVEGKIVIKSPNSISHQAIRLSVNGSVNLQVRGGSAGVIESF 961
T + +K+ R+N++Y + E + G +VI S +S+ HQ + L++ G+VNLQ+ S GV E+F
Sbjct: 3 TALDIKIKRANKVYHAGEVLSGVVVISSKDSVQHQGVSLTMEGTVNLQLSAKSVGVFEAF 62
Query: 960 YGVIKPIQILKKTIEVRSSGRIPPGTTEIPFSVNLREPAESIAEKFYETFHGTNINIQYL 781
Y +KPIQI+ TIE+ G+ P G TEIPF L + YET+HG +NIQY
Sbjct: 63 YNSVKPIQIINSTIEMVKPGKFPSGKTEIPFEFPLHLKGNKV---LYETYHGVFVNIQYT 119
Query: 780 LTADIPRGYLHKPLSATVEFIIESGRVDLPERPLPPEMVIFYIT-QDTQRHPLLPDIKTG 604
L D+ R L K L+ T EFI+ S P P + I T Q+ + LLP
Sbjct: 120 LRCDMKRSLLAKDLTKTCEFIVHSAPQKGKFTPSPVDFTITPETLQNVKERALLPK---- 175
Query: 603 GFRVTGKL-ATQCSLQDPLSGELTVEASSVPITSIDIHLLRVESIIVGERIVTETSLIQS 427
F + G L +T C + PL+GEL VE+S I S+++ L+RVE+ E + + IQ+
Sbjct: 176 -FLLRGHLNSTNCVITQPLTGELVVESSEAAIRSVELQLVRVETCGCAEGYARDATEIQN 234
Query: 426 TQIADGDVCRKMTLPIYVLLPRLLMCPSIFAGPFSVEFKVCITI 295
QIADGDVCR +++PIY++ PRL CP++ F VEF+V I +
Sbjct: 235 IQIADGDVCRGLSVPIYMVFPRLFTCPTLETTNFKVEFEVNIVV 278
>sp|Q5RF33|DSCR3_PONAB Down syndrome critical region protein 3 homolog OS=Pongo
abelii GN=DSCR3 PE=2 SV=1
Length = 297
Score = 210 bits (532), Expect = 3e-053
Identities = 116/288 (40%), Positives = 169/288 (58%), Gaps = 18/288 (6%)
Frame = -1
Query: 1140 TTVTVKLSRSNRIYRSSEAVEGKIVIKSPNSISHQAIRLSVNGSVNLQVRGGSAGVIESF 961
T + +K+ R+N++Y + E + G +VI S +S+ HQ + L++ G+VNLQ+ S GV E+F
Sbjct: 3 TALDIKIKRANKVYHAGEVLSGVVVISSKDSVQHQGVSLTMEGTVNLQLSAKSVGVFEAF 62
Query: 960 YGVIKPIQILKKTIEVRSSGRIPPGTTEIPFSVNLREPAESIAEKFYETFHGTNINIQYL 781
Y +KPIQI+ IE+ G+ P G TEIPF L + YET+HG +NIQY
Sbjct: 63 YNSVKPIQIINSNIEMVKPGKFPSGKTEIPFEFPLHVKGNKV---LYETYHGVFVNIQYT 119
Query: 780 LTADIPRGYLHKPLSATVEFIIESGRVDLPER-PLPPEMVIFYIT----QDTQRHPLLPD 616
L D+ R L K L+ T EFI+ S P++ P V F IT Q+ + LLP
Sbjct: 120 LRCDMKRSLLAKDLTKTCEFIVHSA----PQKGKFSPSPVHFTITPETLQNARERALLPK 175
Query: 615 IKTGGFRVTGKL-ATQCSLQDPLSGELTVEASSVPITSIDIHLLRVESIIVGERIVTETS 439
F + G L +T C + PL+GEL VE+S I S+++ L+RVE+ E + +
Sbjct: 176 -----FLLRGHLNSTNCVITQPLTGELVVESSEAAIRSVELQLVRVETCGCAEGYARDAT 230
Query: 438 LIQSTQIADGDVCRKMTLPIYVLLPRLLMCPSIFAGPFSVEFKVCITI 295
IQ+ QIADGDVCR +++PIY++ PRL CP++ F VEF+V I +
Sbjct: 231 EIQNIQIADGDVCRGLSVPIYMVFPRLFTCPTLETTNFKVEFEVNIVV 278
>sp|Q54DI8|DSCR3_DICDI Down syndrome critical region protein 3 homolog
OS=Dictyostelium discoideum GN=DDB_G0292212 PE=3 SV=1
Length = 304
Score = 177 bits (447), Expect = 2e-043
Identities = 99/285 (34%), Positives = 162/285 (56%), Gaps = 12/285 (4%)
Frame = -1
Query: 1128 VKLSRSNRIYRSSEAVEGKIVIKSPNSISHQAIRLSVNGSVNLQVRGGSAGVIESFYGVI 949
+KL + ++IYR V G +VI S + +SH + + V G+V LQ+ S G+ E+FY +
Sbjct: 7 LKLKKIDKIYRPGSKVSGNVVINSKDDMSHSGVTIVVEGTVQLQLSSKSVGLFEAFYNSL 66
Query: 948 KPIQILKKTIEV-RSSGRIPPGTTEIPFSVNLREPAESIAEKFYETFHGTNINIQYLLTA 772
KPI ++ TI V G+ G TE+PF L EP + ++ Y+T+HG +NIQY +
Sbjct: 67 KPITLMHYTISVTNGGGKFQAGITELPFEFTL-EPLPN--QQLYDTYHGVFVNIQYSIKC 123
Query: 771 DIPRGYLHKPLSATVEFIIE--SGRVDLPERPLPPEMVIFYITQDTQ---RHPLLPDIKT 607
D+ RG L K LS T+EFI+E S ++ + P ++ F IT D+ + D+ T
Sbjct: 124 DVKRGILSKDLSKTIEFIVEVPSQNKEVLMKSTPESLITFNITPDSLVNFKKISKADVPT 183
Query: 606 GGFRVTGKLATQ-CSLQDPLSGELTVEASSVPITSIDIHLLRVESIIVGERIVTETSLIQ 430
F+++G L + C++ + G + +E++ I S+++ L+RVE+ + E + IQ
Sbjct: 184 --FKISGGLVSAICNINEAFQGHMIIESADTVIKSVELQLVRVETCGCADGYAREVTEIQ 241
Query: 429 STQIADGDVCRKMTLPIYVLLPRLLMCPSIFAGPFSVEFKVCITI 295
+ QIADGD+ R +P+Y++ PRL C S F +EF+V + I
Sbjct: 242 NIQIADGDIWRNFKIPLYMVFPRLFTCISTAGKTFKIEFEVNLVI 286
Database: UniProt/SwissProt
Posted date: Sat Aug 07 14:36:18 2010
Number of letters in database: 182,829,261
Number of sequences in database: 518,415
Lambda K H
0.267 0.041 0.140
Gapped
Lambda K H
0.267 0.041 0.140
Matrix: blosum62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 151,686,369,441
Number of Sequences: 518415
Number of Extensions: 151686369441
Number of Successful Extensions: 928182970
Number of sequences better than 0.0: 0
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