BLASTX 7.6.2
Query= UN40195 /QuerySize=1415
(1414 letters)
Database: UniProt/SwissProt;
518,415 sequences; 182,829,261 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|O04130|SERA_ARATH D-3-phosphoglycerate dehydrogenase, chlorop... 612 2e-174
sp|O29445|SERA_ARCFU D-3-phosphoglycerate dehydrogenase OS=Archa... 205 7e-052
sp|P35136|SERA_BACSU D-3-phosphoglycerate dehydrogenase OS=Bacil... 202 6e-051
sp|O27051|SERA_METTH D-3-phosphoglycerate dehydrogenase OS=Metha... 195 7e-049
sp|P73821|SERA_SYNY3 D-3-phosphoglycerate dehydrogenase OS=Synec... 193 3e-048
sp|O08651|SERA_RAT D-3-phosphoglycerate dehydrogenase OS=Rattus ... 187 2e-046
sp|Q61753|SERA_MOUSE D-3-phosphoglycerate dehydrogenase OS=Mus m... 186 3e-046
sp|Q60HD7|SERA_MACFA D-3-phosphoglycerate dehydrogenase OS=Macac... 185 7e-046
sp|A5GFY8|SERA_PIG D-3-phosphoglycerate dehydrogenase OS=Sus scr... 185 7e-046
sp|O43175|SERA_HUMAN D-3-phosphoglycerate dehydrogenase OS=Homo ... 184 1e-045
sp|A5A6P1|SERA_PANTR D-3-phosphoglycerate dehydrogenase OS=Pan t... 184 1e-045
sp|Q5R7M2|SERA_PONAB D-3-phosphoglycerate dehydrogenase OS=Pongo... 183 5e-045
sp|Q5EAD2|SERA_BOVIN D-3-phosphoglycerate dehydrogenase OS=Bos t... 177 2e-043
sp|O33116|SERA_MYCLE D-3-phosphoglycerate dehydrogenase OS=Mycob... 174 2e-042
sp|P0A545|SERA_MYCBO D-3-phosphoglycerate dehydrogenase OS=Mycob... 171 2e-041
sp|P0A544|SERA_MYCTU D-3-phosphoglycerate dehydrogenase OS=Mycob... 171 2e-041
sp|B1L765|GYAR_KORCO Glyoxylate reductase OS=Korarchaeum cryptof... 134 2e-030
sp|B6YWH0|GYAR_THEON Glyoxylate reductase OS=Thermococcus onnuri... 129 8e-029
sp|A1RYE4|GYAR_THEPD Glyoxylate reductase OS=Thermofilum pendens... 121 2e-026
sp|A7MKR1|GHRB_ENTS8 Glyoxylate/hydroxypyruvate reductase B OS=E... 116 5e-025
>sp|O04130|SERA_ARATH D-3-phosphoglycerate dehydrogenase, chloroplastic
OS=Arabidopsis thaliana GN=At1g17745 PE=1 SV=2
Length = 624
Score = 612 bits (1578), Expect = 2e-174
Identities = 306/400 (76%), Positives = 359/400 (89%)
Frame = +2
Query: 2 AVMGFGKVGTEVARRAKGLGMRVIARDPYAPADLAHAIGVELVSFDEALATADFISLHMP 181
AVMGFGKVGTEVARRAKGLGM VI+ DPYAPAD A A+GV+LVSFD+A++TADF+SLHMP
Sbjct: 225 AVMGFGKVGTEVARRAKGLGMTVISHDPYAPADRARALGVDLVSFDQAISTADFVSLHMP 284
Query: 182 LTPATNKILNDETFAKMKKGVRIVNVARGGVIDEDALVRALDAGIVAQAALDVFTKEPPA 361
LTPAT K+ NDETF+KMKKGVR++NVARGGVIDEDALVRALDAGIVAQAALDVF +EPP+
Sbjct: 285 LTPATKKVFNDETFSKMKKGVRLINVARGGVIDEDALVRALDAGIVAQAALDVFCEEPPS 344
Query: 362 KDSPLVQHERVTVTPHLGASTMEAQEGVAIEIAEAVVGALNGELAATAVNAPMVSAEVLT 541
KDS L+QHE VTVTPHLGAST EAQEGVAIEIAEAV GAL GEL+ATAVNAPMV+ EVL+
Sbjct: 345 KDSRLIQHENVTVTPHLGASTKEAQEGVAIEIAEAVAGALKGELSATAVNAPMVAPEVLS 404
Query: 542 ELKPYVILAEKLGRLAVQLVAGGSGVKNVKVSYTSARATDDLDTRLLRAMITKGIIEPIS 721
EL PY++LAEKLGRLAVQL +GG GV++++V Y SAR DDLDTRLLRAMITKGIIEPIS
Sbjct: 405 ELTPYIVLAEKLGRLAVQLASGGKGVQSIRVVYRSARDRDDLDTRLLRAMITKGIIEPIS 464
Query: 722 DVYVNLVNADFTAKQRGLRLSEERVLLDGSPENPLETITVQLGNVESKFASSLSESGEVK 901
D YVNLVNADF AKQ+GLR+SEER+++D SPE P+++I VQ+ NVES FA ++S++G++
Sbjct: 465 DSYVNLVNADFIAKQKGLRISEERMVVDSSPEYPVDSIQVQILNVESNFAGAVSDAGDIS 524
Query: 902 VEGRVKDGIPHLTKVGSFEVDVTLEGSIILCRQVDQPGMIGTVGSILGESNVNVNFMSVG 1081
+EG+VK G+PHLT VGSF VDV+LEG++ILCRQVDQPGMIG VG+ILGE NVNVNFMSVG
Sbjct: 525 IEGKVKYGVPHLTCVGSFGVDVSLEGNLILCRQVDQPGMIGQVGNILGEQNVNVNFMSVG 584
Query: 1082 RIAPRKQAIMAIGVDDQPSKETLKKIGEIPAVEEFVFLKL 1201
R RKQAIMAIGVD++P +TL++IG + A+EEFVFLKL
Sbjct: 585 RTVLRKQAIMAIGVDEEPDNKTLERIGGVSAIEEFVFLKL 624
>sp|O29445|SERA_ARCFU D-3-phosphoglycerate dehydrogenase OS=Archaeoglobus
fulgidus GN=serA PE=3 SV=1
Length = 527
Score = 205 bits (521), Expect = 7e-052
Identities = 114/264 (43%), Positives = 162/264 (61%), Gaps = 4/264 (1%)
Frame = +2
Query: 5 VMGFGKVGTEVARRAKGLGMRVIARDPYAPADLAHAIGVELVSFDEALATADFISLHMPL 184
V+G G+VG EVA+R K L M V+A DP+ + A IGV+LV FD LA++D I++H+P
Sbjct: 144 VIGLGRVGFEVAKRCKALEMNVLAYDPFVSKERAEQIGVKLVDFDTLLASSDVITVHVPR 203
Query: 185 TPATNKILNDETFAKMKKGVRIVNVARGGVIDEDALVRALDAGIVAQAALDVFTKEPPAK 364
T T ++ F KMK GV +VN ARGG++DE AL A+ AG VA AALDV+ KEPP+
Sbjct: 204 TKETIGLIGKGQFEKMKDGVIVVNAARGGIVDEAALYEAIKAGKVAAAALDVYEKEPPSP 263
Query: 365 DSPLVQHERVTVTPHLGASTMEAQEGVAIEIAEAVVGALNGELAATAVNAPMVSAEVLTE 544
D+PL++ + V TPH+ AST EAQ V + IAE +V G AVN P +
Sbjct: 264 DNPLLKLDNVVTTPHIAASTREAQLNVGMIIAEDIVNMAKGLPVRNAVNLPSIEPSDFEF 323
Query: 545 LKPYVILAEKLGRLAVQLVAGGSGVKNVKVSYTSARATDDLDTRLLRAMITKGIIEPISD 724
+ P++ LAEK+G++A V G ++ VKV+ + AT +T + + KG+ EPI
Sbjct: 324 MMPFLTLAEKMGKIA--SVRLGGAIRKVKVTCSGKLATK--NTEFVTRALLKGLFEPILS 379
Query: 725 VYVNLVNADFTAKQRGLRLSEERV 796
+NLV+A A +RG+ + E +V
Sbjct: 380 NEINLVSAKPVAVERGITIEESKV 403
>sp|P35136|SERA_BACSU D-3-phosphoglycerate dehydrogenase OS=Bacillus subtilis
GN=serA PE=3 SV=3
Length = 525
Score = 202 bits (513), Expect = 6e-051
Identities = 114/262 (43%), Positives = 161/262 (61%), Gaps = 5/262 (1%)
Frame = +2
Query: 5 VMGFGKVGTEVARRAKGLGMRVIARDPYAPADLAHAIGVELVSFDEALATADFISLHMPL 184
++G G++G+E+A+RA+ GM V DP+ + A IGV +F+E L +AD I++H PL
Sbjct: 143 IVGLGRIGSEIAQRARAFGMTVHVFDPFLTEERAKKIGVNSRTFEEVLESADIITVHTPL 202
Query: 185 TPATNKILNDETFAKMKKGVRIVNVARGGVIDEDALVRALDAGIVAQAALDVFTKEPPAK 364
T T +LN ET AK KKGVR++N ARGG+IDE AL+ AL+ G VA AALDVF EPP
Sbjct: 203 TKETKGLLNKETIAKTKKGVRLINCARGGIIDEAALLEALENGHVAGAALDVFEVEPPV- 261
Query: 365 DSPLVQHERVTVTPHLGASTMEAQEGVAIEIAEAVVGALNGELAATAVNAPMVSAEVLTE 544
D+ LV H V TPHLGAST EAQ VA +++E V+ G +A+N P ++ + +
Sbjct: 262 DNKLVDHPLVIATPHLGASTKEAQLNVAAQVSEEVLQFAKGLPVMSAINLPAMTKDEFAK 321
Query: 545 LKPYVILAEKLGRLAVQLVAGGSGVKNVKVSYTSARATDDLDTRLLRAMITKGIIEPISD 724
+KPY +A K+G L Q + V++V + Y A L+T + + G ++P D
Sbjct: 322 IKPYHQIAGKIGSLVSQCMK--EPVQDVAIQYEGTIA--KLETSFITKALLSGFLKPRVD 377
Query: 725 VYVNLVNADFTAKQRGLRLSEE 790
VN VNA AK+RG+ SE+
Sbjct: 378 STVNEVNAGGVAKERGISFSEK 399
>sp|O27051|SERA_METTH D-3-phosphoglycerate dehydrogenase OS=Methanobacterium
thermoautotrophicum GN=serA PE=3 SV=1
Length = 525
Score = 195 bits (495), Expect = 7e-049
Identities = 104/263 (39%), Positives = 157/263 (59%), Gaps = 5/263 (1%)
Frame = +2
Query: 5 VMGFGKVGTEVARRAKGLGMRVIARDPYAPADLAHAIGVELVSFDEALATADFISLHMPL 184
++G G++G++V R K GM ++ DPY + A +GV + + L +D +++H+PL
Sbjct: 146 IIGMGRIGSQVVVRTKAFGMDIMVYDPYISKEAAEEMGVTVTDLETLLRESDIVTIHVPL 205
Query: 185 TPATNKILNDETFAKMKKGVRIVNVARGGVIDEDALVRALDAGIVAQAALDVFTKEPPAK 364
TP T +++++ F MK IVN ARGG+IDEDAL RAL G +A AALDVF +EPP +
Sbjct: 206 TPETRHLISEDEFKLMKDTAFIVNCARGGIIDEDALYRALKDGEIAGAALDVFEEEPP-E 264
Query: 365 DSPLVQHERVTVTPHLGASTMEAQEGVAIEIAEAVVGALNGELAATAVNAPMVSAEVLTE 544
SPL++ E V +TPH+GAST EAQ AI +A + G +N P++ +E
Sbjct: 265 GSPLLELENVVLTPHIGASTSEAQRDAAIIVANEIKTVFQGGAPRNVLNMPVMDSETYKS 324
Query: 545 LKPYVILAEKLGRLAVQLVAGGSGVKNVKVSYTSARATDDLDTRLLRAMITKGIIEPISD 724
LKPY+ LAEK+G + Q + G ++ + V+Y A D +L + + I+ PI
Sbjct: 325 LKPYIELAEKMGAIIAQALPG--NIEKLDVTYCGELAEMQFD--ILTRTMLQAILNPILT 380
Query: 725 VYVNLVNADFTAKQRGLRLSEER 793
VNL+NA AK+RG+ ++E R
Sbjct: 381 EPVNLINAPSIAKKRGIMVTEAR 403
>sp|P73821|SERA_SYNY3 D-3-phosphoglycerate dehydrogenase OS=Synechocystis sp.
(strain PCC 6803) GN=serA PE=3 SV=1
Length = 554
Score = 193 bits (490), Expect = 3e-048
Identities = 113/263 (42%), Positives = 160/263 (60%), Gaps = 4/263 (1%)
Frame = +2
Query: 5 VMGFGKVGTEVARRAKGLGMRVIARDPYAPADLAHAIGVELVSFDEALATADFISLHMPL 184
V+G GK+G+ VA AK +GM+++A DP+ + A IG LV D + ADFI+LH+P
Sbjct: 172 VVGLGKIGSHVAGVAKAMGMKLLAYDPFISQERADQIGCTLVDLDLLFSEADFITLHIPK 231
Query: 185 TPATNKILNDETFAKMKKGVRIVNVARGGVIDEDALVRALDAGIVAQAALDVFTKEPPAK 364
TP T ++N ET AKMK RI+N +RGG+IDE+ALV A++ + AALDVF +E P
Sbjct: 232 TPETANLINAETLAKMKPTARIINCSRGGIIDEEALVTAIETAQIGGAALDVFAQE-PLG 290
Query: 365 DSPLVQHERVTVTPHLGASTMEAQEGVAIEIAEAVVGALNGELAATAVNAPMVSAEVLTE 544
+S L + V +TPHLGAST EAQ VA+++AE + L G A +AVN P ++ +V+ +
Sbjct: 291 ESRLREFSNVILTPHLGASTEEAQVNVAVDVAEQIRDVLLGLPARSAVNIPGLTPDVMEK 350
Query: 545 LKPYVILAEKLGRLAVQLVAGGSGVKNVKVSYTSARATDDLDTRLLRAMITKGIIEPISD 724
L+PY+ LAE LG L QL G V + A T +++ L KG++
Sbjct: 351 LRPYLKLAETLGTLVGQLAGGRIDRLTVCLQGDLAEYT---NSQPLVVAAIKGLLSQALR 407
Query: 725 VYVNLVNADFTAKQRGLRLSEER 793
VN VNA AK+RG+R+ E +
Sbjct: 408 ERVNYVNAAIEAKERGIRVIETK 430
>sp|O08651|SERA_RAT D-3-phosphoglycerate dehydrogenase OS=Rattus norvegicus
GN=Phgdh PE=1 SV=3
Length = 533
Score = 187 bits (474), Expect = 2e-046
Identities = 109/260 (41%), Positives = 148/260 (56%), Gaps = 4/260 (1%)
Frame = +2
Query: 5 VMGFGKVGTEVARRAKGLGMRVIARDPYAPADLAHAIGVELVSFDEALATADFISLHMPL 184
++G G++G EVA R + GM+ + DP ++A + GV+ + +E DFI++H PL
Sbjct: 150 ILGLGRIGREVAARMQAFGMKTVGYDPIISPEVAASFGVQQLPLEEIWPLCDFITVHTPL 209
Query: 185 TPATNKILNDETFAKMKKGVRIVNVARGGVIDEDALVRALDAGIVAQAALDVFTKEPPAK 364
P+T +LND TFA+ KKGVR+VN ARGG++DE AL+RAL +G A AALDVFT+EPP +
Sbjct: 210 LPSTTGLLNDSTFAQCKKGVRVVNCARGGIVDEGALLRALQSGQCAGAALDVFTEEPP-R 268
Query: 365 DSPLVQHERVTVTPHLGASTMEAQEGVAIEIAEAVVGALNGELAATAVNAPMVSAEVLTE 544
D LV HE V PHLGAST EAQ EIA V + G+ VNA +++
Sbjct: 269 DRALVDHENVISCPHLGASTKEAQSRCGEEIAVQFVDMVKGKSLTGVVNAQALTSAFSPH 328
Query: 545 LKPYVILAEKLGRLAVQLVAGGSGVKNVKVSYTSARATDDLDTRLLRAMITKGIIEPISD 724
KP++ LAE LG L G V TS + + T L A+I + E
Sbjct: 329 TKPWIGLAEALGTLMHAWAGSPKGTIQVVTQGTSLK---NAGTCLSPAVIVGLLREASKQ 385
Query: 725 VYVNLVNADFTAKQRGLRLS 784
VNLVNA K+ GL ++
Sbjct: 386 ADVNLVNAKLLVKEAGLNVT 405
>sp|Q61753|SERA_MOUSE D-3-phosphoglycerate dehydrogenase OS=Mus musculus
GN=Phgdh PE=1 SV=3
Length = 533
Score = 186 bits (472), Expect = 3e-046
Identities = 108/260 (41%), Positives = 148/260 (56%), Gaps = 4/260 (1%)
Frame = +2
Query: 5 VMGFGKVGTEVARRAKGLGMRVIARDPYAPADLAHAIGVELVSFDEALATADFISLHMPL 184
++G G++G EVA R + GM+ + DP ++A + GV+ + +E DFI++H PL
Sbjct: 150 ILGLGRIGREVATRMQSFGMKTVGYDPIISPEVAASFGVQQLPLEEIWPLCDFITVHTPL 209
Query: 185 TPATNKILNDETFAKMKKGVRIVNVARGGVIDEDALVRALDAGIVAQAALDVFTKEPPAK 364
P+T +LND TFA+ KKGVR+VN ARGG++DE AL+RAL +G A AALDVFT+EPP +
Sbjct: 210 LPSTTGLLNDSTFAQCKKGVRVVNCARGGIVDEGALLRALQSGQCAGAALDVFTEEPP-R 268
Query: 365 DSPLVQHERVTVTPHLGASTMEAQEGVAIEIAEAVVGALNGELAATAVNAPMVSAEVLTE 544
D LV HE V PHLGAST EAQ EIA V + G+ VNA +++
Sbjct: 269 DRALVDHENVISCPHLGASTKEAQSRCGEEIAVQFVDMVKGKSLTGVVNAQALTSAFSPH 328
Query: 545 LKPYVILAEKLGRLAVQLVAGGSGVKNVKVSYTSARATDDLDTRLLRAMITKGIIEPISD 724
KP++ LAE +G L G V TS + + T L A+I + E
Sbjct: 329 TKPWIGLAEAMGTLMHAWAGSPKGTIQVVTQGTSLK---NAGTCLSPAVIVGLLREASKQ 385
Query: 725 VYVNLVNADFTAKQRGLRLS 784
VNLVNA K+ GL ++
Sbjct: 386 ADVNLVNAKLLVKEAGLNVT 405
>sp|Q60HD7|SERA_MACFA D-3-phosphoglycerate dehydrogenase OS=Macaca fascicularis
GN=PHGDH PE=2 SV=4
Length = 533
Score = 185 bits (469), Expect = 7e-046
Identities = 109/257 (42%), Positives = 146/257 (56%), Gaps = 4/257 (1%)
Frame = +2
Query: 5 VMGFGKVGTEVARRAKGLGMRVIARDPYAPADLAHAIGVELVSFDEALATADFISLHMPL 184
++G G++G EVA R + GM+ I DP +++ + GV+ + +E DFI++H PL
Sbjct: 150 ILGLGRIGREVATRMQSFGMKTIGYDPIISPEVSASFGVQQLPLEEIWPLCDFITVHTPL 209
Query: 185 TPATNKILNDETFAKMKKGVRIVNVARGGVIDEDALVRALDAGIVAQAALDVFTKEPPAK 364
P+T +LND TFA+ KKGVR+VN ARGG++DE AL+RAL +G A AALDVFT+EPP +
Sbjct: 210 LPSTTGLLNDNTFAQCKKGVRVVNCARGGIVDEGALLRALQSGQCAGAALDVFTEEPP-R 268
Query: 365 DSPLVQHERVTVTPHLGASTMEAQEGVAIEIAEAVVGALNGELAATAVNAPMVSAEVLTE 544
D LV HE V PHLGAST EAQ EIA V + G+ A VNA +++
Sbjct: 269 DRALVDHENVISCPHLGASTKEAQSRCGEEIAVQFVDMVKGKSLAGVVNAQALTSAFSPH 328
Query: 545 LKPYVILAEKLGRLAVQLVAGGSGVKNVKVSYTSARATDDLDTRLLRAMITKGIIEPISD 724
KP++ LAE LG L G V TS + + L A+I + E
Sbjct: 329 TKPWIGLAEALGTLMRAWAGSPKGTIQVITQGTSLKNAGNC---LSPAVIVGLLKEASKQ 385
Query: 725 VYVNLVNADFTAKQRGL 775
VNLVNA K+ GL
Sbjct: 386 ADVNLVNAKLLVKEAGL 402
>sp|A5GFY8|SERA_PIG D-3-phosphoglycerate dehydrogenase OS=Sus scrofa GN=PHGDH
PE=3 SV=1
Length = 533
Score = 185 bits (469), Expect = 7e-046
Identities = 110/260 (42%), Positives = 148/260 (56%), Gaps = 4/260 (1%)
Frame = +2
Query: 5 VMGFGKVGTEVARRAKGLGMRVIARDPYAPADLAHAIGVELVSFDEALATADFISLHMPL 184
++G G++G EVA R + GM+ I DP +++ + GV+ + +E DFI++H PL
Sbjct: 150 ILGLGRIGREVATRMQSFGMKTIGYDPIIAPEVSASFGVQQLPLEEIWPLCDFITVHTPL 209
Query: 185 TPATNKILNDETFAKMKKGVRIVNVARGGVIDEDALVRALDAGIVAQAALDVFTKEPPAK 364
P+T +LND TFA KKGVR+VN ARGG++DE AL+RAL +G A AALDVFT+EPP +
Sbjct: 210 LPSTTGLLNDSTFALCKKGVRVVNCARGGIVDEGALLRALQSGQCAGAALDVFTEEPP-R 268
Query: 365 DSPLVQHERVTVTPHLGASTMEAQEGVAIEIAEAVVGALNGELAATAVNAPMVSAEVLTE 544
D LV HE+V PHLGAST EAQ EIA V + G A VNA +++
Sbjct: 269 DRALVDHEKVISCPHLGASTREAQSRCGEEIAIQFVDMVKGRSLAGVVNAQALTSAFSPH 328
Query: 545 LKPYVILAEKLGRLAVQLVAGGSGVKNVKVSYTSARATDDLDTRLLRAMITKGIIEPISD 724
KP++ LAE LG L G V TS + + T L A+I + E
Sbjct: 329 TKPWIGLAEALGALMQAWAGSPKGTIQVVTQGTSLK---NSGTCLSPAVIVGLLKEASHR 385
Query: 725 VYVNLVNADFTAKQRGLRLS 784
VNLVNA K+ GL ++
Sbjct: 386 ADVNLVNAKLLEKEAGLHVT 405
>sp|O43175|SERA_HUMAN D-3-phosphoglycerate dehydrogenase OS=Homo sapiens
GN=PHGDH PE=1 SV=4
Length = 533
Score = 184 bits (467), Expect = 1e-045
Identities = 108/260 (41%), Positives = 147/260 (56%), Gaps = 4/260 (1%)
Frame = +2
Query: 5 VMGFGKVGTEVARRAKGLGMRVIARDPYAPADLAHAIGVELVSFDEALATADFISLHMPL 184
++G G++G EVA R + GM+ I DP +++ + GV+ + +E DFI++H PL
Sbjct: 150 ILGLGRIGREVATRMQSFGMKTIGYDPIISPEVSASFGVQQLPLEEIWPLCDFITVHTPL 209
Query: 185 TPATNKILNDETFAKMKKGVRIVNVARGGVIDEDALVRALDAGIVAQAALDVFTKEPPAK 364
P+T +LND TFA+ KKGVR+VN ARGG++DE AL+RAL +G A AALDVFT+EPP +
Sbjct: 210 LPSTTGLLNDNTFAQCKKGVRVVNCARGGIVDEGALLRALQSGQCAGAALDVFTEEPP-R 268
Query: 365 DSPLVQHERVTVTPHLGASTMEAQEGVAIEIAEAVVGALNGELAATAVNAPMVSAEVLTE 544
D LV HE V PHLGAST EAQ EIA V + G+ VNA +++
Sbjct: 269 DRALVDHENVISCPHLGASTKEAQSRCGEEIAVQFVDMVKGKSLTGVVNAQALTSAFSPH 328
Query: 545 LKPYVILAEKLGRLAVQLVAGGSGVKNVKVSYTSARATDDLDTRLLRAMITKGIIEPISD 724
KP++ LAE LG L G V TS + + L A+I + E
Sbjct: 329 TKPWIGLAEALGTLMRAWAGSPKGTIQVITQGTSLKNAGNC---LSPAVIVGLLKEASKQ 385
Query: 725 VYVNLVNADFTAKQRGLRLS 784
VNLVNA K+ GL ++
Sbjct: 386 ADVNLVNAKLLVKEAGLNVT 405
>sp|A5A6P1|SERA_PANTR D-3-phosphoglycerate dehydrogenase OS=Pan troglodytes
GN=PHGDH PE=2 SV=1
Length = 533
Score = 184 bits (467), Expect = 1e-045
Identities = 108/260 (41%), Positives = 147/260 (56%), Gaps = 4/260 (1%)
Frame = +2
Query: 5 VMGFGKVGTEVARRAKGLGMRVIARDPYAPADLAHAIGVELVSFDEALATADFISLHMPL 184
++G G++G EVA R + GM+ I DP +++ + GV+ + +E DFI++H PL
Sbjct: 150 ILGLGRIGREVATRMQSFGMKTIGYDPIISPEVSASFGVQQLPLEEIWPLCDFITVHTPL 209
Query: 185 TPATNKILNDETFAKMKKGVRIVNVARGGVIDEDALVRALDAGIVAQAALDVFTKEPPAK 364
P+T +LND TFA+ KKGVR+VN ARGG++DE AL+RAL +G A AALDVFT+EPP +
Sbjct: 210 LPSTTGLLNDNTFAQCKKGVRVVNCARGGIVDEGALLRALQSGQCAGAALDVFTEEPP-R 268
Query: 365 DSPLVQHERVTVTPHLGASTMEAQEGVAIEIAEAVVGALNGELAATAVNAPMVSAEVLTE 544
D LV HE V PHLGAST EAQ EIA V + G+ VNA +++
Sbjct: 269 DRALVDHENVISCPHLGASTKEAQSRCGEEIAVQFVDMVKGKSLTGVVNAQALTSAFSPH 328
Query: 545 LKPYVILAEKLGRLAVQLVAGGSGVKNVKVSYTSARATDDLDTRLLRAMITKGIIEPISD 724
KP++ LAE LG L G V TS + + L A+I + E
Sbjct: 329 TKPWIGLAEALGTLMRAWAGSPKGTIQVITQGTSLKNAGNC---LSPAVIVGLLKEASKQ 385
Query: 725 VYVNLVNADFTAKQRGLRLS 784
VNLVNA K+ GL ++
Sbjct: 386 ADVNLVNAKLLVKEAGLNVT 405
>sp|Q5R7M2|SERA_PONAB D-3-phosphoglycerate dehydrogenase OS=Pongo abelii
GN=PHGDH PE=2 SV=3
Length = 533
Score = 183 bits (462), Expect = 5e-045
Identities = 108/260 (41%), Positives = 147/260 (56%), Gaps = 4/260 (1%)
Frame = +2
Query: 5 VMGFGKVGTEVARRAKGLGMRVIARDPYAPADLAHAIGVELVSFDEALATADFISLHMPL 184
++G G++G EVA R + LGM+ I DP +++ + GV+ + +E DFI++H PL
Sbjct: 150 ILGLGRIGREVAIRMQSLGMKTIGYDPIISPEVSASFGVQQLPLEEIWPLCDFITVHTPL 209
Query: 185 TPATNKILNDETFAKMKKGVRIVNVARGGVIDEDALVRALDAGIVAQAALDVFTKEPPAK 364
P+T +LND TFA+ KKGVR+VN ARGG++DE AL+RAL +G A AALDVFT+EPP +
Sbjct: 210 LPSTTGLLNDNTFAQCKKGVRVVNCARGGIVDEGALLRALQSGQCAGAALDVFTEEPP-R 268
Query: 365 DSPLVQHERVTVTPHLGASTMEAQEGVAIEIAEAVVGALNGELAATAVNAPMVSAEVLTE 544
LV HE V PHLGAST EAQ EIA V + G+ VNA +++
Sbjct: 269 GRALVDHENVISCPHLGASTKEAQSRCGEEIAVQFVDMVKGKSLTGVVNAQALTSAFSPH 328
Query: 545 LKPYVILAEKLGRLAVQLVAGGSGVKNVKVSYTSARATDDLDTRLLRAMITKGIIEPISD 724
KP++ LAE LG L G V TS + + L A+I + E
Sbjct: 329 TKPWIGLAEALGTLMRAWAGSPKGAIQVITQGTSLKNAGNC---LSPAVIVGLLKEASKQ 385
Query: 725 VYVNLVNADFTAKQRGLRLS 784
VNLVNA K+ GL ++
Sbjct: 386 ADVNLVNAKLLVKEAGLNVT 405
>sp|Q5EAD2|SERA_BOVIN D-3-phosphoglycerate dehydrogenase OS=Bos taurus GN=PHGDH
PE=2 SV=3
Length = 533
Score = 177 bits (448), Expect = 2e-043
Identities = 105/257 (40%), Positives = 145/257 (56%), Gaps = 4/257 (1%)
Frame = +2
Query: 5 VMGFGKVGTEVARRAKGLGMRVIARDPYAPADLAHAIGVELVSFDEALATADFISLHMPL 184
++G G++G EVA R + GM+ I DP +++ + GV+ + ++ DFI++H PL
Sbjct: 150 ILGLGRIGREVATRMQSFGMKTIGYDPIISPEVSASFGVQQLPLEQIWPLCDFITVHTPL 209
Query: 185 TPATNKILNDETFAKMKKGVRIVNVARGGVIDEDALVRALDAGIVAQAALDVFTKEPPAK 364
P+T +LND TFA+ KKGV +VN ARGG++DE AL+RAL +G A AALDVFT+EPP +
Sbjct: 210 LPSTTGLLNDSTFAQCKKGVCVVNCARGGIVDEGALLRALQSGQCAGAALDVFTEEPP-R 268
Query: 365 DSPLVQHERVTVTPHLGASTMEAQEGVAIEIAEAVVGALNGELAATAVNAPMVSAEVLTE 544
D LV HE V PHLGAST EAQ EIA V + G+ A VNA +++
Sbjct: 269 DRALVNHENVISCPHLGASTKEAQSRCGEEIALQFVDMVKGKALAGVVNAQALASIFCPH 328
Query: 545 LKPYVILAEKLGRLAVQLVAGGSGVKNVKVSYTSARATDDLDTRLLRAMITKGIIEPISD 724
KP+V LA+ LG L G V T + + + L A+I + +
Sbjct: 329 TKPWVSLAKALGALMQAWAGSPKGAIQV---VTQGSSLKNSGSCLAPAVIIGLLKDASQQ 385
Query: 725 VYVNLVNADFTAKQRGL 775
VNLVNA K+ GL
Sbjct: 386 SNVNLVNAMLLVKEAGL 402
>sp|O33116|SERA_MYCLE D-3-phosphoglycerate dehydrogenase OS=Mycobacterium leprae
GN=serA PE=3 SV=1
Length = 528
Score = 174 bits (439), Expect = 2e-042
Identities = 109/257 (42%), Positives = 147/257 (57%), Gaps = 7/257 (2%)
Frame = +2
Query: 5 VMGFGKVGTEVARRAKGLGMRVIARDPYAPADLAHAIGVELVSFDEALATADFISLHMPL 184
V+G G++G VA R G VIA DPY A +G+EL+SFD+ LA ADFIS+H+P
Sbjct: 146 VVGLGRIGQLVAARIAAFGAHVIAYDPYVAPARAAQLGIELMSFDDLLARADFISVHLPK 205
Query: 185 TPATNKILNDETFAKMKKGVRIVNVARGGVIDEDALVRALDAGIVAQAALDVFTKEPPAK 364
TP T +++ E AK K GV IVN ARGG++DE AL A+ +G V A LDVF E P
Sbjct: 206 TPETAGLIDKEALAKTKPGVIIVNAARGGLVDEVALADAVRSGHVRAAGLDVFATE-PCT 264
Query: 365 DSPLVQHERVTVTPHLGASTMEAQEGVAIEIAEAVVGALNGELAATAVNAPMVSAEVLTE 544
DSPL + +V VTPHLGAST EAQ+ ++AE+V AL GE AVN V E
Sbjct: 265 DSPLFELSQVVVTPHLGASTAEAQDRAGTDVAESVRLALAGEFVPDAVNVD--GGVVNEE 322
Query: 545 LKPYVILAEKLGRLAVQLVAGGSGVKNVKVSYTSARATDDLDTRLLRAMITKGIIEPISD 724
+ P++ L KLG L L ++ V A++D++ +LR +G+ + +
Sbjct: 323 VAPWLDLVCKLGVLVAAL--SDELPASLSVHVRGELASEDVE--ILRLSALRGLFSTVIE 378
Query: 725 VYVNLVNADFTAKQRGL 775
V VNA A +RG+
Sbjct: 379 DAVTFVNAPALAAERGV 395
>sp|P0A545|SERA_MYCBO D-3-phosphoglycerate dehydrogenase OS=Mycobacterium bovis
GN=serA PE=3 SV=1
Length = 528
Score = 171 bits (431), Expect = 2e-041
Identities = 107/257 (41%), Positives = 147/257 (57%), Gaps = 7/257 (2%)
Frame = +2
Query: 5 VMGFGKVGTEVARRAKGLGMRVIARDPYAPADLAHAIGVELVSFDEALATADFISLHMPL 184
V+G G++G VA+R G V+A DPY A +G+EL+S D+ LA ADFIS+H+P
Sbjct: 146 VVGLGRIGQLVAQRIAAFGAYVVAYDPYVSPARAAQLGIELLSLDDLLARADFISVHLPK 205
Query: 185 TPATNKILNDETFAKMKKGVRIVNVARGGVIDEDALVRALDAGIVAQAALDVFTKEPPAK 364
TP T +++ E AK K GV IVN ARGG++DE AL A+ G V A LDVF E P
Sbjct: 206 TPETAGLIDKEALAKTKPGVIIVNAARGGLVDEAALADAITGGHVRAAGLDVFATE-PCT 264
Query: 365 DSPLVQHERVTVTPHLGASTMEAQEGVAIEIAEAVVGALNGELAATAVNAPMVSAEVLTE 544
DSPL + +V VTPHLGAST EAQ+ ++AE+V AL GE AVN + V E
Sbjct: 265 DSPLFELAQVVVTPHLGASTAEAQDRAGTDVAESVRLALAGEFVPDAVN--VGGGVVNEE 322
Query: 545 LKPYVILAEKLGRLAVQLVAGGSGVKNVKVSYTSARATDDLDTRLLRAMITKGIIEPISD 724
+ P++ L KLG LA V ++ V A ++++ +LR +G+ + +
Sbjct: 323 VAPWLDLVRKLGVLAG--VLSDELPVSLSVQVRGELAAEEVE--VLRLSALRGLFSAVIE 378
Query: 725 VYVNLVNADFTAKQRGL 775
V VNA A +RG+
Sbjct: 379 DAVTFVNAPALAAERGV 395
>sp|P0A544|SERA_MYCTU D-3-phosphoglycerate dehydrogenase OS=Mycobacterium
tuberculosis GN=serA PE=1 SV=1
Length = 528
Score = 171 bits (431), Expect = 2e-041
Identities = 107/257 (41%), Positives = 147/257 (57%), Gaps = 7/257 (2%)
Frame = +2
Query: 5 VMGFGKVGTEVARRAKGLGMRVIARDPYAPADLAHAIGVELVSFDEALATADFISLHMPL 184
V+G G++G VA+R G V+A DPY A +G+EL+S D+ LA ADFIS+H+P
Sbjct: 146 VVGLGRIGQLVAQRIAAFGAYVVAYDPYVSPARAAQLGIELLSLDDLLARADFISVHLPK 205
Query: 185 TPATNKILNDETFAKMKKGVRIVNVARGGVIDEDALVRALDAGIVAQAALDVFTKEPPAK 364
TP T +++ E AK K GV IVN ARGG++DE AL A+ G V A LDVF E P
Sbjct: 206 TPETAGLIDKEALAKTKPGVIIVNAARGGLVDEAALADAITGGHVRAAGLDVFATE-PCT 264
Query: 365 DSPLVQHERVTVTPHLGASTMEAQEGVAIEIAEAVVGALNGELAATAVNAPMVSAEVLTE 544
DSPL + +V VTPHLGAST EAQ+ ++AE+V AL GE AVN + V E
Sbjct: 265 DSPLFELAQVVVTPHLGASTAEAQDRAGTDVAESVRLALAGEFVPDAVN--VGGGVVNEE 322
Query: 545 LKPYVILAEKLGRLAVQLVAGGSGVKNVKVSYTSARATDDLDTRLLRAMITKGIIEPISD 724
+ P++ L KLG LA V ++ V A ++++ +LR +G+ + +
Sbjct: 323 VAPWLDLVRKLGVLAG--VLSDELPVSLSVQVRGELAAEEVE--VLRLSALRGLFSAVIE 378
Query: 725 VYVNLVNADFTAKQRGL 775
V VNA A +RG+
Sbjct: 379 DAVTFVNAPALAAERGV 395
>sp|B1L765|GYAR_KORCO Glyoxylate reductase OS=Korarchaeum cryptofilum (strain
OPF8) GN=gyaR PE=3 SV=1
Length = 332
Score = 134 bits (336), Expect = 2e-030
Identities = 67/173 (38%), Positives = 104/173 (60%)
Frame = +2
Query: 5 VMGFGKVGTEVARRAKGLGMRVIARDPYAPADLAHAIGVELVSFDEALATADFISLHMPL 184
++G G++G VARRAKG GMR++ D D +GVE V ++ L +DF+SLH+PL
Sbjct: 152 IVGMGRIGAAVARRAKGFGMRILYYDSIRREDFEKELGVEYVPLEKLLEESDFVSLHVPL 211
Query: 185 TPATNKILNDETFAKMKKGVRIVNVARGGVIDEDALVRALDAGIVAQAALDVFTKEPPAK 364
T T ++ +E +MK+ +VN +RG V+D+ AL +AL G +A A LDVF +EP
Sbjct: 212 TEETYHMIGEEQLRRMKRTAILVNTSRGKVVDQKALYKALKEGWIAGAGLDVFEQEPIPP 271
Query: 365 DSPLVQHERVTVTPHLGASTMEAQEGVAIEIAEAVVGALNGELAATAVNAPMV 523
D PL++ E V + PH +++ E + +A +AE ++ GE+ VN +V
Sbjct: 272 DDPLLKLENVVLAPHAASASHETRSRMAEMVAENLIAFKRGEIPPNLVNQEVV 324
>sp|B6YWH0|GYAR_THEON Glyoxylate reductase OS=Thermococcus onnurineus (strain
NA1) GN=gyaR PE=3 SV=1
Length = 334
Score = 129 bits (322), Expect = 8e-029
Identities = 67/174 (38%), Positives = 106/174 (60%), Gaps = 1/174 (0%)
Frame = +2
Query: 5 VMGFGKVGTEVARRAKGLGMRVIARDPYAPADLAHAIGVELVSFDEALATADFISLHMPL 184
++GFG++G +ARRAKG GMR++ ++ +G E + DE L +DF+ L +PL
Sbjct: 155 IVGFGRIGQAIARRAKGFGMRILYNSRTRKPEVEKELGAEFMPLDELLKESDFVVLVVPL 214
Query: 185 TPATNKILNDETFAKMKKGVRIVNVARGGVIDEDALVRALDAGIVAQAALDVFTKEPPAK 364
T T ++N+E MK +VN+ARG V+D +ALV+AL G +A A LDVF +EP
Sbjct: 215 TKETYHMINEERLKLMKPTAILVNIARGKVVDTEALVKALREGWIAGAGLDVFEEEPYYH 274
Query: 365 DSPLVQHERVTVTPHLGASTMEAQEGVAIEIAEAVVGALNGELAATAVNAPMVS 526
+ L + V + PH+G++T A+EG+A +A ++ NGE+ T VN +++
Sbjct: 275 EE-LFSLDNVVLAPHIGSATYGAREGMAELVARNLIAFKNGEVPPTLVNREVLN 327
>sp|A1RYE4|GYAR_THEPD Glyoxylate reductase OS=Thermofilum pendens (strain Hrk 5)
GN=gyaR PE=3 SV=1
Length = 339
Score = 121 bits (302), Expect = 2e-026
Identities = 62/183 (33%), Positives = 105/183 (57%), Gaps = 1/183 (0%)
Frame = +2
Query: 5 VMGFGKVGTEVARRAKGLGMRVIARDPYAPADLAHAI-GVELVSFDEALATADFISLHMP 181
++G G++G A+R ++++ D D+ I +E D L +D +S+H+P
Sbjct: 154 LVGLGRIGVATAKRLSSFDVKILYYDIERRWDVETVIPNMEFTDLDTLLEKSDIVSIHVP 213
Query: 182 LTPATNKILNDETFAKMKKGVRIVNVARGGVIDEDALVRALDAGIVAQAALDVFTKEPPA 361
LT T ++N+E KMKK ++N ARG V+D +ALV+AL G +A AALDVF +EP
Sbjct: 214 LTKETYHLINEERLRKMKKTAYLINTARGPVVDTEALVKALKEGWIAGAALDVFEQEPLP 273
Query: 362 KDSPLVQHERVTVTPHLGASTMEAQEGVAIEIAEAVVGALNGELAATAVNAPMVSAEVLT 541
+ PL + + V + PH+ ++T+EA++ +A A ++ L GE+ VN ++ L
Sbjct: 274 PNHPLTKFDNVVLAPHIASATIEARQRMAELAARNLIAVLKGEMPPALVNKEVLKVRPLE 333
Query: 542 ELK 550
++K
Sbjct: 334 KVK 336
>sp|A7MKR1|GHRB_ENTS8 Glyoxylate/hydroxypyruvate reductase B OS=Enterobacter
sakazakii (strain ATCC BAA-894) GN=ghrB PE=3 SV=1
Length = 324
Score = 116 bits (289), Expect = 5e-025
Identities = 60/174 (34%), Positives = 98/174 (56%), Gaps = 1/174 (0%)
Frame = +2
Query: 5 VMGFGKVGTEVARRAK-GLGMRVIARDPYAPADLAHAIGVELVSFDEALATADFISLHMP 181
++G G++G +A+RA G M ++ ++ D LA +DF+ + +P
Sbjct: 150 IVGMGRIGLALAQRAHFGFNMPILYNARRHHSEAEERFNARYCDLDTLLAESDFVCVILP 209
Query: 182 LTPATNKILNDETFAKMKKGVRIVNVARGGVIDEDALVRALDAGIVAQAALDVFTKEPPA 361
LT T+ ++ E F KMKK +N RG V+DE+AL+ AL +G + A LDVF +EP +
Sbjct: 210 LTDETHHMIGAEQFRKMKKSAIFINAGRGPVVDENALIAALQSGEIHAAGLDVFEQEPLS 269
Query: 362 KDSPLVQHERVTVTPHLGASTMEAQEGVAIEIAEAVVGALNGELAATAVNAPMV 523
KDSPL+ + V PH+G++T E + +A + ++ ALNG+++ VN V
Sbjct: 270 KDSPLLTMKNVVALPHIGSATHETRYNMAACAVDNLINALNGDVSQNCVNPKAV 323
Database: UniProt/SwissProt
Posted date: Sat Aug 07 14:36:18 2010
Number of letters in database: 182,829,261
Number of sequences in database: 518,415
Lambda K H
0.267 0.041 0.140
Gapped
Lambda K H
0.267 0.041 0.140
Matrix: blosum62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 155,740,548,379
Number of Sequences: 518415
Number of Extensions: 155740548379
Number of Successful Extensions: 952083542
Number of sequences better than 0.0: 0
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