BLASTX 7.6.2
Query= UN42393 /QuerySize=912
(911 letters)
Database: UniProt/SwissProt;
518,415 sequences; 182,829,261 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|O80397|M2K4_ARATH Mitogen-activated protein kinase kinase 4 O... 365 3e-100
sp|Q8RXG3|M2K5_ARATH Mitogen-activated protein kinase kinase 5 O... 320 1e-086
sp|Q5QN75|M2K1_ORYSJ Mitogen-activated protein kinase kinase 1 O... 158 5e-038
sp|Q9FJV0|M2K6_ARATH Mitogen-activated protein kinase kinase 6 O... 146 3e-034
sp|Q9S7U9|M2K2_ARATH Mitogen-activated protein kinase kinase 2 O... 141 8e-033
sp|Q94A06|M2K1_ARATH Mitogen-activated protein kinase kinase 1 O... 138 5e-032
sp|Q54JG7|DST4_DICDI Serine/threonine-protein kinase dst4 OS=Dic... 127 2e-028
sp|Q55CL6|MP2K1_DICDI Dual specificity mitogen-activated protein... 110 2e-023
sp|Q9H2G2|SLK_HUMAN STE20-like serine/threonine-protein kinase O... 104 1e-021
sp|O55092|SLK_CAVPO STE20-like serine/threonine-protein kinase O... 104 1e-021
sp|O54988|SLK_MOUSE STE20-like serine/threonine-protein kinase O... 104 1e-021
sp|O08815|SLK_RAT STE20-like serine/threonine-protein kinase OS=... 104 1e-021
sp|O95819|M4K4_HUMAN Mitogen-activated protein kinase kinase kin... 102 3e-021
sp|P97820|M4K4_MOUSE Mitogen-activated protein kinase kinase kin... 102 4e-021
sp|Q7Z2Y5|NRK_HUMAN Nik-related protein kinase OS=Homo sapiens G... 99 5e-020
sp|Q9UKE5|TNIK_HUMAN TRAF2 and NCK-interacting protein kinase OS... 98 6e-020
sp|P83510|TNIK_MOUSE Traf2 and NCK-interacting protein kinase OS... 98 6e-020
sp|Q9JM52|MINK1_MOUSE Misshapen-like kinase 1 OS=Mus musculus GN... 96 2e-019
sp|Q8N4C8|MINK1_HUMAN Misshapen-like kinase 1 OS=Homo sapiens GN... 96 4e-019
sp|Q5R754|CDKL2_PONAB Cyclin-dependent kinase-like 2 OS=Pongo ab... 83 3e-015
>sp|O80397|M2K4_ARATH Mitogen-activated protein kinase kinase 4 OS=Arabidopsis
thaliana GN=MKK4 PE=1 SV=1
Length = 366
Score = 365 bits (936), Expect = 3e-100
Identities = 181/208 (87%), Positives = 191/208 (91%), Gaps = 1/208 (0%)
Frame = +3
Query: 3 MDEGSLEGRHVSNERDLAKLSFQILNGLAYLHGRHIVHRDIKPSNLLVNKAANVKIADFG 182
MD+GSLEG HV E+ LA LS QIL+GLAYLH RHIVHRDIKPSNLL+N A NVKIADFG
Sbjct: 157 MDKGSLEGAHVWKEQQLADLSRQILSGLAYLHSRHIVHRDIKPSNLLINSAKNVKIADFG 216
Query: 183 VSRILAQTMDPCNSSVGTIAYMSPERINTDLNQGRYDGYAGDIWSLGVSILEFFLGRFPF 362
VSRILAQTMDPCNSSVGTIAYMSPERINTDLNQG+YDGYAGDIWSLGVSILEF+LGRFPF
Sbjct: 217 VSRILAQTMDPCNSSVGTIAYMSPERINTDLNQGKYDGYAGDIWSLGVSILEFYLGRFPF 276
Query: 363 NVSRQGDWASLMCAICMSQPPEAPASASPEFRHFISRCLQREPGRRMTASQLLRHPFILR 542
VSRQGDWASLMCAICMSQPPEAPA+ASPEFRHFIS CLQREPG+R +A QLL+HPFILR
Sbjct: 277 PVSRQGDWASLMCAICMSQPPEAPATASPEFRHFISCCLQREPGKRRSAMQLLQHPFILR 336
Query: 543 GASQGQNRSPQNPHQLLPPPRPLSSSSS 626
AS QNRSPQN HQLLPPPRPLSSSSS
Sbjct: 337 -ASPSQNRSPQNLHQLLPPPRPLSSSSS 363
>sp|Q8RXG3|M2K5_ARATH Mitogen-activated protein kinase kinase 5 OS=Arabidopsis
thaliana GN=MKK5 PE=1 SV=2
Length = 348
Score = 320 bits (818), Expect = 1e-086
Identities = 158/201 (78%), Positives = 175/201 (87%), Gaps = 6/201 (2%)
Frame = +3
Query: 3 MDEGSLEGRHVSNERDLAKLSFQILNGLAYLHGRHIVHRDIKPSNLLVNKAANVKIADFG 182
MD+GSLEG H+ E++LA LS QIL+GLAYLH RHIVHRDIKPSNLL+N A NVKIADFG
Sbjct: 148 MDQGSLEGAHIWQEQELADLSRQILSGLAYLHRRHIVHRDIKPSNLLINSAKNVKIADFG 207
Query: 183 VSRILAQTMDPCNSSVGTIAYMSPERINTDLNQGRYDGYAGDIWSLGVSILEFFLGRFPF 362
VSRILAQTMDPCNSSVGTIAYMSPERINTDLN GRYDGYAGD+WSLGVSILEF+LGRFPF
Sbjct: 208 VSRILAQTMDPCNSSVGTIAYMSPERINTDLNHGRYDGYAGDVWSLGVSILEFYLGRFPF 267
Query: 363 NVSRQGDWASLMCAICMSQPPEAPASASPEFRHFISRCLQREPGRRMTASQLLRHPFILR 542
VSRQGDWASLMCAICMSQPPEAPA+AS EFRHF+S CLQ +P +R +A QLL+HPFIL+
Sbjct: 268 AVSRQGDWASLMCAICMSQPPEAPATASQEFRHFVSCCLQSDPPKRWSAQQLLQHPFILK 327
Query: 543 GASQGQNRSPQNPHQLLPPPR 605
A+ G N Q+LPPPR
Sbjct: 328 -ATGGPNL-----RQMLPPPR 342
>sp|Q5QN75|M2K1_ORYSJ Mitogen-activated protein kinase kinase 1 OS=Oryza sativa
subsp. japonica GN=MEK1 PE=1 SV=1
Length = 355
Score = 158 bits (399), Expect = 5e-038
Identities = 90/167 (53%), Positives = 109/167 (65%), Gaps = 10/167 (5%)
Frame = +3
Query: 51 LAKLSFQILNGLAYL-HGRHIVHRDIKPSNLLVNKAANVKIADFGVSRILAQTMDPCNSS 227
LA L Q+L GL YL H RH++HRDIKPSNLLVN+ VKI DFGVS +LA +M ++
Sbjct: 169 LAVLCKQVLEGLLYLHHERHVIHRDIKPSNLLVNRKGEVKITDFGVSAVLASSMGQRDTF 228
Query: 228 VGTIAYMSPERINTDLNQGRYDGYAGDIWSLGVSILEFFLGRFPFNVSRQGDWAS---LM 398
VGT YM+PERI+ G Y DIWSLG+ ILE +GRFP+ S W S L+
Sbjct: 229 VGTYNYMAPERIS-----GSSYDYKSDIWSLGLVILECAIGRFPYIPSEGEGWLSFYELL 283
Query: 399 CAICMSQPPEAPASA-SPEFRHFISRCLQREPGRRMTASQLLRHPFI 536
AI PP APA SPEF FIS C+Q++P RM+AS+LL HPFI
Sbjct: 284 EAIVDQPPPSAPADQFSPEFCAFISSCIQKDPAERMSASELLNHPFI 330
>sp|Q9FJV0|M2K6_ARATH Mitogen-activated protein kinase kinase 6 OS=Arabidopsis
thaliana GN=MKK6 PE=1 SV=1
Length = 356
Score = 146 bits (367), Expect = 3e-034
Identities = 83/168 (49%), Positives = 107/168 (63%), Gaps = 11/168 (6%)
Frame = +3
Query: 51 LAKLSFQILNGLAYLHG-RHIVHRDIKPSNLLVNKAANVKIADFGVSRILAQTMDPCNSS 227
LA + Q+L GL YLH RH++HRDIKPSNLLVN VKI+DFGVS LA +M ++
Sbjct: 169 LAVVCKQVLLGLVYLHNERHVIHRDIKPSNLLVNHKGEVKISDFGVSASLASSMGQRDTF 228
Query: 228 VGTIAYMSPERINTDLNQGRYDGYAGDIWSLGVSILEFFLGRFPFNVSRQ----GDWASL 395
VGT YMSPERI+ G Y+ DIWSLG+S+LE +GRFP+ S + L
Sbjct: 229 VGTYNYMSPERIS-----GSTYDYSSDIWSLGMSVLECAIGRFPYLESEDQQNPPSFYEL 283
Query: 396 MCAICMSQPPEAPASA-SPEFRHFISRCLQREPGRRMTASQLLRHPFI 536
+ AI + PP AP+ SPEF F+S C+Q++P R ++ LL HPFI
Sbjct: 284 LAAIVENPPPTAPSDQFSPEFCSFVSACIQKDPPARASSLDLLSHPFI 331
>sp|Q9S7U9|M2K2_ARATH Mitogen-activated protein kinase kinase 2 OS=Arabidopsis
thaliana GN=MKK2 PE=1 SV=2
Length = 363
Score = 141 bits (354), Expect = 8e-033
Identities = 82/177 (46%), Positives = 105/177 (59%), Gaps = 11/177 (6%)
Frame = +3
Query: 51 LAKLSFQILNGLAYL-HGRHIVHRDIKPSNLLVNKAANVKIADFGVSRILAQTMDPCNSS 227
L+ + Q+L GL YL H RHI+HRD+KPSNLL+N VKI DFGVS ++ T N+
Sbjct: 168 LSAIFRQVLQGLIYLHHDRHIIHRDLKPSNLLINHRGEVKITDFGVSTVMTNTAGLANTF 227
Query: 228 VGTIAYMSPERINTDLNQGRYDGYAGDIWSLGVSILEFFLGRFPFNVSRQGD-WAS---L 395
VGT YMSPERI G G DIWSLG+ +LE G+FP+ Q + W S L
Sbjct: 228 VGTYNYMSPERI-----VGNKYGNKSDIWSLGLVVLECATGKFPYAPPNQEETWTSVFEL 282
Query: 396 MCAICMSQPPEAPA-SASPEFRHFISRCLQREPGRRMTASQLLRHPFILRGASQGQN 563
M AI PP P+ + SPE FIS CLQ++P R +A +L+ HPF+ + G N
Sbjct: 283 MEAIVDQPPPALPSGNFSPELSSFISTCLQKDPNSRSSAKELMEHPFLNKYDYSGIN 339
>sp|Q94A06|M2K1_ARATH Mitogen-activated protein kinase kinase 1 OS=Arabidopsis
thaliana GN=MKK1 PE=1 SV=2
Length = 354
Score = 138 bits (347), Expect = 5e-032
Identities = 79/171 (46%), Positives = 107/171 (62%), Gaps = 11/171 (6%)
Frame = +3
Query: 42 ERDLAKLSFQILNGLAYL-HGRHIVHRDIKPSNLLVNKAANVKIADFGVSRILAQTMDPC 218
E L+ + ++L GL Y+ H R I+HRD+KPSNLL+N VKI DFGVS+IL T
Sbjct: 163 ENMLSAICKRVLRGLCYIHHERRIIHRDLKPSNLLINHRGEVKITDFGVSKILTSTSSLA 222
Query: 219 NSSVGTIAYMSPERINTDLNQGRYDGYAGDIWSLGVSILEFFLGRFPFN-VSRQGDWAS- 392
NS VGT YMSPERI+ L + DIWSLG+ +LE G+FP+ + W+S
Sbjct: 223 NSFVGTYPYMSPERISGSLYSNK-----SDIWSLGLVLLECATGKFPYTPPEHKKGWSSV 277
Query: 393 --LMCAICMSQPPEAPASA-SPEFRHFISRCLQREPGRRMTASQLLRHPFI 536
L+ AI + PP AP++ SPEF FIS+C+Q++P R +A +LL H F+
Sbjct: 278 YELVDAIVENPPPCAPSNLFSPEFCSFISQCVQKDPRDRKSAKELLEHKFV 328
>sp|Q54JG7|DST4_DICDI Serine/threonine-protein kinase dst4 OS=Dictyostelium
discoideum GN=dst4 PE=3 SV=1
Length = 485
Score = 127 bits (317), Expect = 2e-028
Identities = 77/188 (40%), Positives = 103/188 (54%), Gaps = 8/188 (4%)
Frame = +3
Query: 42 ERDLAKLSFQILNGLAYLHGRHIVHRDIKPSNLLVNKAANVKIADFGVSRILAQTMDPCN 221
E +A + +QI+ GL YLH I+HRDIK N+LVNK K+ADFGVS IL T
Sbjct: 116 EAQIAAILYQIVEGLVYLHSNKILHRDIKAGNVLVNKLGQAKLADFGVSAILVNTGFKQK 175
Query: 222 SSVGTIAYMSPERINTDLNQGRYDGYAGDIWSLGVSILEFFLGRFP-FNVSRQGDWASLM 398
+ VG+ +MSPE I+ YD A DIWSLG++ +E + P FN++ ++
Sbjct: 176 TVVGSPYWMSPEVISPPKGSNGYDSKA-DIWSLGITAIEMAESKPPLFNLNP----VKVI 230
Query: 399 CAICMSQPP--EAPASASPEFRHFISRCLQREPGRRMTASQLLRHPFILRGASQGQNRSP 572
I Q P E P + SPEF FIS CL +E +R +A LL HPFI +G Q
Sbjct: 231 FVIPFRQAPTLEVPGNWSPEFNDFISVCLNKEADKRPSAVDLLNHPFIKKGKEHSQPTIS 290
Query: 573 QNPHQLLP 596
+ Q +P
Sbjct: 291 EMVEQCIP 298
>sp|Q55CL6|MP2K1_DICDI Dual specificity mitogen-activated protein kinase kinase
1 OS=Dictyostelium discoideum GN=mekA PE=1 SV=1
Length = 660
Score = 110 bits (273), Expect = 2e-023
Identities = 55/105 (52%), Positives = 73/105 (69%), Gaps = 6/105 (5%)
Frame = +3
Query: 51 LAKLSFQILNGLAYLHGR-HIVHRDIKPSNLLVNKAANVKIADFGVSRILAQTMDPCNSS 227
L K++FQ+L GL YLH + H++HRDIKPSN+LVN KIADFGVS L T+ +
Sbjct: 390 LGKIAFQVLQGLVYLHRKLHLIHRDIKPSNILVNNKGEAKIADFGVSGQLQHTLSKAVTW 449
Query: 228 VGTIAYMSPERINTDLNQGRYDGYAGDIWSLGVSILEFFLGRFPF 362
VGT+ YMSPERI+ GR + +IWSLG++ILE +G+FP+
Sbjct: 450 VGTVTYMSPERIS-----GRSYSFDSEIWSLGLTILECAIGKFPY 489
>sp|Q9H2G2|SLK_HUMAN STE20-like serine/threonine-protein kinase OS=Homo sapiens
GN=SLK PE=1 SV=1
Length = 1235
Score = 104 bits (258), Expect = 1e-021
Identities = 59/180 (32%), Positives = 98/180 (54%), Gaps = 5/180 (2%)
Frame = +3
Query: 3 MDEGSLEGRHVSNERDLAKLSFQILNGLAYLHGRHIVHRDIKPSNLLVNKAANVKIADFG 182
+D LE E + + Q L+ L YLH I+HRD+K N+L ++K+ADFG
Sbjct: 116 VDAVMLELERPLTESQIQVVCKQTLDALNYLHDNKIIHRDLKAGNILFTLDGDIKLADFG 175
Query: 183 VSRILAQTMDPCNSSVGTIAYMSPERINTDLNQGRYDGYAGDIWSLGVSILEFFLGRFPF 362
VS +T+ +S +GT +M+PE + + ++ R Y D+WSLG++++E P
Sbjct: 176 VSAKNTRTIQRRDSFIGTPYWMAPEVVMCETSKDRPYDYKADVWSLGITLIEMAEIEPPH 235
Query: 363 NVSRQGDWASLMCAICMSQPP--EAPASASPEFRHFISRCLQREPGRRMTASQLLRHPFI 536
+ + + ++ I S+PP P+ S F+ F+ +CL++ R T SQLL+HPF+
Sbjct: 236 H---ELNPMRVLLKIAKSEPPTLAQPSRWSSNFKDFLKKCLEKNVDARWTTSQLLQHPFV 292
>sp|O55092|SLK_CAVPO STE20-like serine/threonine-protein kinase OS=Cavia
porcellus GN=SLK PE=1 SV=1
Length = 1231
Score = 104 bits (257), Expect = 1e-021
Identities = 59/180 (32%), Positives = 97/180 (53%), Gaps = 5/180 (2%)
Frame = +3
Query: 3 MDEGSLEGRHVSNERDLAKLSFQILNGLAYLHGRHIVHRDIKPSNLLVNKAANVKIADFG 182
+D LE E + + Q L L YLH I+HRD+K N+L ++K+ADFG
Sbjct: 116 VDAVMLELERPLTESQIQVVCKQTLEALNYLHDNKIIHRDLKAGNILFTLDGDIKLADFG 175
Query: 183 VSRILAQTMDPCNSSVGTIAYMSPERINTDLNQGRYDGYAGDIWSLGVSILEFFLGRFPF 362
VS +T+ +S +GT +M+PE + + ++ R Y D+WSLG++++E P
Sbjct: 176 VSAKNTRTIQRRDSFIGTPYWMAPEVVMCETSKDRPYDYKADVWSLGITLIEMAEIEPPH 235
Query: 363 NVSRQGDWASLMCAICMSQPP--EAPASASPEFRHFISRCLQREPGRRMTASQLLRHPFI 536
+ + + ++ I S+PP P+ S F+ F+ +CL++ R T SQLL+HPF+
Sbjct: 236 H---ELNPMRVLLKIAKSEPPTLAQPSRWSSNFKDFLKKCLEKNVDARWTTSQLLQHPFV 292
>sp|O54988|SLK_MOUSE STE20-like serine/threonine-protein kinase OS=Mus musculus
GN=Slk PE=1 SV=2
Length = 1233
Score = 104 bits (257), Expect = 1e-021
Identities = 59/180 (32%), Positives = 97/180 (53%), Gaps = 5/180 (2%)
Frame = +3
Query: 3 MDEGSLEGRHVSNERDLAKLSFQILNGLAYLHGRHIVHRDIKPSNLLVNKAANVKIADFG 182
+D LE E + + Q L L YLH I+HRD+K N+L ++K+ADFG
Sbjct: 116 VDAVMLELERPLTESQIQVVCKQTLEALNYLHDNKIIHRDLKAGNILFTLDGDIKLADFG 175
Query: 183 VSRILAQTMDPCNSSVGTIAYMSPERINTDLNQGRYDGYAGDIWSLGVSILEFFLGRFPF 362
VS +T+ +S +GT +M+PE + + ++ R Y D+WSLG++++E P
Sbjct: 176 VSAKNTRTIQRRDSFIGTPYWMAPEVVMCETSKDRPYDYKADVWSLGITLIEMAEIEPPH 235
Query: 363 NVSRQGDWASLMCAICMSQPP--EAPASASPEFRHFISRCLQREPGRRMTASQLLRHPFI 536
+ + + ++ I S+PP P+ S F+ F+ +CL++ R T SQLL+HPF+
Sbjct: 236 H---ELNPMRVLLKIAKSEPPTLAQPSKWSSNFKDFLRKCLEKNVDARWTTSQLLQHPFV 292
>sp|O08815|SLK_RAT STE20-like serine/threonine-protein kinase OS=Rattus
norvegicus GN=Slk PE=1 SV=1
Length = 1206
Score = 104 bits (257), Expect = 1e-021
Identities = 59/180 (32%), Positives = 97/180 (53%), Gaps = 5/180 (2%)
Frame = +3
Query: 3 MDEGSLEGRHVSNERDLAKLSFQILNGLAYLHGRHIVHRDIKPSNLLVNKAANVKIADFG 182
+D LE E + + Q L L YLH I+HRD+K N+L ++K+ADFG
Sbjct: 116 VDAVMLELERPLTESQIQVVCKQTLEALNYLHDNKIIHRDLKAGNILFTLDGDIKLADFG 175
Query: 183 VSRILAQTMDPCNSSVGTIAYMSPERINTDLNQGRYDGYAGDIWSLGVSILEFFLGRFPF 362
VS +T+ +S +GT +M+PE + + ++ R Y D+WSLG++++E P
Sbjct: 176 VSAKNTRTIQRRDSFIGTPYWMAPEVVMCETSKDRPYDYKADVWSLGITLIEMAEIEPPH 235
Query: 363 NVSRQGDWASLMCAICMSQPP--EAPASASPEFRHFISRCLQREPGRRMTASQLLRHPFI 536
+ + + ++ I S+PP P+ S F+ F+ +CL++ R T SQLL+HPF+
Sbjct: 236 H---ELNPMRVLLKIAKSEPPTLAQPSRWSSNFKDFLKKCLEKNVDARWTTSQLLQHPFV 292
>sp|O95819|M4K4_HUMAN Mitogen-activated protein kinase kinase kinase kinase 4
OS=Homo sapiens GN=MAP4K4 PE=1 SV=2
Length = 1239
Score = 102 bits (254), Expect = 3e-021
Identities = 64/179 (35%), Positives = 94/179 (52%), Gaps = 4/179 (2%)
Frame = +3
Query: 51 LAKLSFQILNGLAYLHGRHIVHRDIKPSNLLVNKAANVKIADFGVSRILAQTMDPCNSSV 230
+A +S +IL GLA+LH H++HRDIK N+L+ + A VK+ DFGVS L +T+ N+ +
Sbjct: 130 IAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFI 189
Query: 231 GTIAYMSPERINTDLNQGRYDGYAGDIWSLGVSILEFFLGRFPFNVSRQGDWASLMCAIC 410
GT +M+PE I D N Y D+WS G++ +E G P + I
Sbjct: 190 GTPYWMAPEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHP---MRALFLIP 246
Query: 411 MSQPPEAPASA-SPEFRHFISRCLQREPGRRMTASQLLRHPFILRGASQGQNRSPQNPH 584
+ PP + S +F FI CL + +R + QLL+HPFI ++ Q R H
Sbjct: 247 RNPPPRLKSKKWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVRIQLKDH 305
>sp|P97820|M4K4_MOUSE Mitogen-activated protein kinase kinase kinase kinase 4
OS=Mus musculus GN=Map4k4 PE=1 SV=1
Length = 1233
Score = 102 bits (253), Expect = 4e-021
Identities = 64/179 (35%), Positives = 94/179 (52%), Gaps = 4/179 (2%)
Frame = +3
Query: 51 LAKLSFQILNGLAYLHGRHIVHRDIKPSNLLVNKAANVKIADFGVSRILAQTMDPCNSSV 230
+A +S +IL GLA+LH H++HRDIK N+L+ + A VK+ DFGVS L +T+ N+ +
Sbjct: 129 IAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFI 188
Query: 231 GTIAYMSPERINTDLNQGRYDGYAGDIWSLGVSILEFFLGRFPFNVSRQGDWASLMCAIC 410
GT +M+PE I D N Y D+WS G++ +E G P + I
Sbjct: 189 GTPYWMAPEVIACDENPDATYDYRSDLWSCGITAIEMAEGGPPLCDMHP---MRALFLIP 245
Query: 411 MSQPPEAPASA-SPEFRHFISRCLQREPGRRMTASQLLRHPFILRGASQGQNRSPQNPH 584
+ PP + S +F FI CL + +R + QLL+HPFI ++ Q R H
Sbjct: 246 RNPPPRLKSKKWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVRIQLKDH 304
>sp|Q7Z2Y5|NRK_HUMAN Nik-related protein kinase OS=Homo sapiens GN=NRK PE=2
SV=2
Length = 1582
Score = 99 bits (244), Expect = 5e-020
Identities = 55/162 (33%), Positives = 91/162 (56%), Gaps = 2/162 (1%)
Frame = +3
Query: 51 LAKLSFQILNGLAYLHGRHIVHRDIKPSNLLVNKAANVKIADFGVSRILAQTMDPCNSSV 230
+A + +IL GLA+LH ++HRDIK N+L+ A VK+ DFGVS +++T NS +
Sbjct: 154 IAYICREILQGLAHLHAHRVIHRDIKGQNVLLTHNAEVKLVDFGVSAQVSRTNGRRNSFI 213
Query: 231 GTIAYMSPERINTDLNQGRYDGYAGDIWSLGVSILEFFLGRFPFNVSRQGDWASLMCAIC 410
GT +M+PE I+ D + R Y D+WS+G++ +E G P + +L +
Sbjct: 214 GTPYWMAPEVIDCDEDPRRSYDYRSDVWSVGITAIEMAEGAPP--LCNLQPLEALFVILR 271
Query: 411 MSQPPEAPASASPEFRHFISRCLQREPGRRMTASQLLRHPFI 536
S P + S +F +F+ +C + R T++ +L+HPF+
Sbjct: 272 ESAPTVKSSGWSRKFHNFMEKCTIKNFLFRPTSANMLQHPFV 313
>sp|Q9UKE5|TNIK_HUMAN TRAF2 and NCK-interacting protein kinase OS=Homo sapiens
GN=TNIK PE=1 SV=1
Length = 1360
Score = 98 bits (243), Expect = 6e-020
Identities = 60/184 (32%), Positives = 94/184 (51%), Gaps = 8/184 (4%)
Frame = +3
Query: 42 ERDLAKLSFQILNGLAYLHGRHIVHRDIKPSNLLVNKAANVKIADFGVSRILAQTMDPCN 221
E +A + +IL GL++LH ++HRDIK N+L+ + A VK+ DFGVS L +T+ N
Sbjct: 127 EEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRN 186
Query: 222 SSVGTIAYMSPERINTDLNQGRYDGYAGDIWSLGVSILEFFLGRFPFNVSRQGDWASLMC 401
+ +GT +M+PE I D N + D+WSLG++ +E G P D +
Sbjct: 187 TFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPL-----CDMHPMRA 241
Query: 402 AICMSQPPEAPASA---SPEFRHFISRCLQREPGRRMTASQLLRHPFILRGASQGQNRSP 572
+ + P + S +F+ FI CL + +R QL++HPFI ++ Q R
Sbjct: 242 LFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRIQ 301
Query: 573 QNPH 584
H
Sbjct: 302 LKDH 305
>sp|P83510|TNIK_MOUSE Traf2 and NCK-interacting protein kinase OS=Mus musculus
GN=Tnik PE=1 SV=2
Length = 1323
Score = 98 bits (243), Expect = 6e-020
Identities = 60/184 (32%), Positives = 94/184 (51%), Gaps = 8/184 (4%)
Frame = +3
Query: 42 ERDLAKLSFQILNGLAYLHGRHIVHRDIKPSNLLVNKAANVKIADFGVSRILAQTMDPCN 221
E +A + +IL GL++LH ++HRDIK N+L+ + A VK+ DFGVS L +T+ N
Sbjct: 127 EEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRN 186
Query: 222 SSVGTIAYMSPERINTDLNQGRYDGYAGDIWSLGVSILEFFLGRFPFNVSRQGDWASLMC 401
+ +GT +M+PE I D N + D+WSLG++ +E G P D +
Sbjct: 187 TFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPL-----CDMHPMRA 241
Query: 402 AICMSQPPEAPASA---SPEFRHFISRCLQREPGRRMTASQLLRHPFILRGASQGQNRSP 572
+ + P + S +F+ FI CL + +R QL++HPFI ++ Q R
Sbjct: 242 LFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRIQ 301
Query: 573 QNPH 584
H
Sbjct: 302 LKDH 305
>sp|Q9JM52|MINK1_MOUSE Misshapen-like kinase 1 OS=Mus musculus GN=Mink1 PE=1
SV=2
Length = 1308
Score = 96 bits (238), Expect = 2e-019
Identities = 63/179 (35%), Positives = 90/179 (50%), Gaps = 4/179 (2%)
Frame = +3
Query: 51 LAKLSFQILNGLAYLHGRHIVHRDIKPSNLLVNKAANVKIADFGVSRILAQTMDPCNSSV 230
+A + +IL GLA+LH ++HRDIK N+L+ + A VK+ DFGVS L +T+ N+ +
Sbjct: 130 IAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFI 189
Query: 231 GTIAYMSPERINTDLNQGRYDGYAGDIWSLGVSILEFFLGRFPFNVSRQGDWASLMCAIC 410
GT +M+PE I D N Y DIWSLG++ +E G P + I
Sbjct: 190 GTPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHP---MRALFLIP 246
Query: 411 MSQPPEAPASA-SPEFRHFISRCLQREPGRRMTASQLLRHPFILRGASQGQNRSPQNPH 584
+ PP + S +F FI CL + R QLL+ PFI ++ Q R H
Sbjct: 247 RNPPPRLKSKKWSKKFTDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRIQLKDH 305
>sp|Q8N4C8|MINK1_HUMAN Misshapen-like kinase 1 OS=Homo sapiens GN=MINK1 PE=1
SV=2
Length = 1332
Score = 96 bits (236), Expect = 4e-019
Identities = 63/179 (35%), Positives = 90/179 (50%), Gaps = 4/179 (2%)
Frame = +3
Query: 51 LAKLSFQILNGLAYLHGRHIVHRDIKPSNLLVNKAANVKIADFGVSRILAQTMDPCNSSV 230
+A + +IL GLA+LH ++HRDIK N+L+ + A VK+ DFGVS L +T+ N+ +
Sbjct: 130 IAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFI 189
Query: 231 GTIAYMSPERINTDLNQGRYDGYAGDIWSLGVSILEFFLGRFPFNVSRQGDWASLMCAIC 410
GT +M+PE I D N Y DIWSLG++ +E G P + I
Sbjct: 190 GTPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHP---MRALFLIP 246
Query: 411 MSQPPEAPASA-SPEFRHFISRCLQREPGRRMTASQLLRHPFILRGASQGQNRSPQNPH 584
+ PP + S +F FI CL + R QLL+ PFI ++ Q R H
Sbjct: 247 RNPPPRLKSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRIQLKDH 305
>sp|Q5R754|CDKL2_PONAB Cyclin-dependent kinase-like 2 OS=Pongo abelii GN=CDKL2
PE=2 SV=1
Length = 493
Score = 83 bits (203), Expect = 3e-015
Identities = 44/117 (37%), Positives = 67/117 (57%), Gaps = 6/117 (5%)
Frame = +3
Query: 57 KLSFQILNGLAYLHGRHIVHRDIKPSNLLVNKAANVKIADFGVSRILAQTMDPCNSSVGT 236
K FQI+NG+ + H +I+HRDIKP N+LV+K+ VK+ DFG +R LA + V T
Sbjct: 105 KYLFQIINGIGFCHSHNIIHRDIKPENILVSKSGVVKLCDFGFARTLAAPGEVYTDYVAT 164
Query: 237 IAYMSPERINTDLNQGRYDGYAGDIWSLGVSILEFFLGR--FPFNVSRQGDWASLMC 401
Y +PE + D+ G+ A D+W++G + E F+G FP + + +MC
Sbjct: 165 RWYRAPELLVGDVKYGK----AVDVWAIGCLVTEMFMGEPLFPGDSDIDQLYHIMMC 217
Database: UniProt/SwissProt
Posted date: Sat Aug 07 14:36:18 2010
Number of letters in database: 182,829,261
Number of sequences in database: 518,415
Lambda K H
0.267 0.041 0.140
Gapped
Lambda K H
0.267 0.041 0.140
Matrix: blosum62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 161,906,083,408
Number of Sequences: 518415
Number of Extensions: 161906083408
Number of Successful Extensions: 1010567443
Number of sequences better than 0.0: 0
|
