BLASTX 7.6.2
Query= UN43166 /QuerySize=872
(871 letters)
Database: UniProt/SwissProt;
518,415 sequences; 182,829,261 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q9M077|AUR1_ARATH Serine/threonine-protein kinase Aurora-1 OS... 378 3e-104
sp|Q683C9|AUR2_ARATH Serine/threonine-protein kinase Aurora-2 OS... 366 2e-100
sp|Q9N0X0|AURKB_PIG Serine/threonine-protein kinase 12 OS=Sus sc... 279 2e-074
sp|P97477|STK6_MOUSE Serine/threonine-protein kinase 6 OS=Mus mu... 277 9e-074
sp|A5GFW1|STK6_PIG Serine/threonine-protein kinase 6 OS=Sus scro... 272 2e-072
sp|P59241|STK6_RAT Serine/threonine-protein kinase 6 OS=Rattus n... 272 2e-072
sp|Q91820|STK6_XENLA Serine/threonine-protein kinase 6 OS=Xenopu... 272 2e-072
sp|Q91819|STK6L_XENLA Serine/threonine-protein kinase Eg2-like O... 272 3e-072
sp|Q7YRC6|AURKB_BOVIN Serine/threonine-protein kinase 12 OS=Bos ... 271 7e-072
sp|Q96GD4|AURKB_HUMAN Serine/threonine-protein kinase 12 OS=Homo... 271 7e-072
sp|Q54WX4|AURK_DICDI Probable serine/threonine-protein kinase au... 270 9e-072
sp|Q6DE08|AUKBA_XENLA Serine/threonine-protein kinase 12-A OS=Xe... 270 1e-071
sp|Q6GPL3|AUKBB_XENLA Serine/threonine-protein kinase 12-B OS=Xe... 270 1e-071
sp|Q2TA06|STK6_BOVIN Serine/threonine-protein kinase 6 OS=Bos ta... 270 1e-071
sp|O14965|STK6_HUMAN Serine/threonine-protein kinase 6 OS=Homo s... 270 1e-071
sp|A4IGM9|AURKB_XENTR Serine/threonine-protein kinase 12 OS=Xeno... 269 2e-071
sp|O70126|AURKB_MOUSE Serine/threonine-protein kinase 12 OS=Mus ... 265 4e-070
sp|O55099|AURKB_RAT Serine/threonine-protein kinase 12 OS=Rattus... 265 5e-070
sp|Q9UQB9|AURKC_HUMAN Serine/threonine-protein kinase 13 OS=Homo... 264 8e-070
sp|O64629|AUR3_ARATH Serine/threonine-protein kinase Aurora-3 OS... 255 3e-067
>sp|Q9M077|AUR1_ARATH Serine/threonine-protein kinase Aurora-1 OS=Arabidopsis
thaliana GN=AUR1 PE=2 SV=1
Length = 294
Score = 378 bits (970), Expect = 3e-104
Identities = 185/198 (93%), Positives = 192/198 (96%), Gaps = 1/198 (0%)
Frame = +1
Query: 85 EKEASDVS-AVAQKRWNLNDFDIGKPLGRGKFGHVYLAREKRSNHIVALKVLFKTQLQQS 261
EKEASD S A AQKRW L+DFDIGKPLGRGKFGHVYLAREKRSNH+VALKVLFK+QLQQS
Sbjct: 11 EKEASDASAAAAQKRWTLSDFDIGKPLGRGKFGHVYLAREKRSNHVVALKVLFKSQLQQS 70
Query: 262 QVEHQLRREVEIQSHLLNPNILRLYGYFYDQKRVYLILEYAARGELYKELQKCKYFSERR 441
QVEHQLRREVEIQSHL +PNILRLYGYFYDQKRVYLILEYAARGELYK+LQKCKYFSERR
Sbjct: 71 QVEHQLRREVEIQSHLRHPNILRLYGYFYDQKRVYLILEYAARGELYKDLQKCKYFSERR 130
Query: 442 AATYVAFLARALIYCHGKHVIHRDIKPENLLIGAQGELKVADFGWSVHTFNRRRTMCGTL 621
AATYVA LARALIYCHGKHVIHRDIKPENLLIGAQGELK+ADFGWSVHTFNRRRTMCGTL
Sbjct: 131 AATYVASLARALIYCHGKHVIHRDIKPENLLIGAQGELKIADFGWSVHTFNRRRTMCGTL 190
Query: 622 DYLPPEMVESVEHDASVE 675
DYLPPEMVESVEHDASV+
Sbjct: 191 DYLPPEMVESVEHDASVD 208
>sp|Q683C9|AUR2_ARATH Serine/threonine-protein kinase Aurora-2 OS=Arabidopsis
thaliana GN=AUR2 PE=2 SV=2
Length = 282
Score = 366 bits (937), Expect = 2e-100
Identities = 177/190 (93%), Positives = 182/190 (95%)
Frame = +1
Query: 106 SAVAQKRWNLNDFDIGKPLGRGKFGHVYLAREKRSNHIVALKVLFKTQLQQSQVEHQLRR 285
S AQKRW +DFDIGKPLGRGKFGHVYLAREKRS+HIVALKVLFK QLQQSQVEHQLRR
Sbjct: 7 SEAAQKRWTTSDFDIGKPLGRGKFGHVYLAREKRSDHIVALKVLFKAQLQQSQVEHQLRR 66
Query: 286 EVEIQSHLLNPNILRLYGYFYDQKRVYLILEYAARGELYKELQKCKYFSERRAATYVAFL 465
EVEIQSHL +PNILRLYGYFYDQKRVYLILEYA RGELYKELQKCKYFSERRAATYVA L
Sbjct: 67 EVEIQSHLRHPNILRLYGYFYDQKRVYLILEYAVRGELYKELQKCKYFSERRAATYVASL 126
Query: 466 ARALIYCHGKHVIHRDIKPENLLIGAQGELKVADFGWSVHTFNRRRTMCGTLDYLPPEMV 645
ARALIYCHGKHVIHRDIKPENLLIGAQGELK+ADFGWSVHTFNRRRTMCGTLDYLPPEMV
Sbjct: 127 ARALIYCHGKHVIHRDIKPENLLIGAQGELKIADFGWSVHTFNRRRTMCGTLDYLPPEMV 186
Query: 646 ESVEHDASVE 675
ESVEHDASV+
Sbjct: 187 ESVEHDASVD 196
>sp|Q9N0X0|AURKB_PIG Serine/threonine-protein kinase 12 OS=Sus scrofa GN=AURKB
PE=2 SV=2
Length = 344
Score = 279 bits (712), Expect = 2e-074
Identities = 132/197 (67%), Positives = 165/197 (83%), Gaps = 1/197 (0%)
Frame = +1
Query: 88 KEASDVSAVAQKRWNLNDFDIGKPLGRGKFGHVYLAREKRSNHIVALKVLFKTQLQQSQV 267
+ +S + + + ++DF+IG+PLG+GKFG+VYLAREK+S+ IVALKVLFK+Q+++ V
Sbjct: 59 ENSSGTPNFSTRSFTIDDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGV 118
Query: 268 EHQLRREVEIQSHLLNPNILRLYGYFYDQKRVYLILEYAARGELYKELQKCKYFSERRAA 447
EHQLRRE+EIQ+HL +PNILRLY YFYD++R+YLILEYA RGELYKELQKC+ F E+R A
Sbjct: 119 EHQLRREIEIQAHLQHPNILRLYNYFYDRRRIYLILEYAPRGELYKELQKCRTFDEQRTA 178
Query: 448 TYVAFLARALIYCHGKHVIHRDIKPENLLIGAQGELKVADFGWSVHTFN-RRRTMCGTLD 624
T + LA ALIYCHGK VIHRDIKPENLL+G QGELK+ADFGWSVH + RR+TMCGTLD
Sbjct: 179 TIMEELADALIYCHGKKVIHRDIKPENLLLGLQGELKIADFGWSVHAPSLRRKTMCGTLD 238
Query: 625 YLPPEMVESVEHDASVE 675
YLPPEM+E H+ V+
Sbjct: 239 YLPPEMIEGRTHNEKVD 255
>sp|P97477|STK6_MOUSE Serine/threonine-protein kinase 6 OS=Mus musculus GN=Aurka
PE=1 SV=1
Length = 395
Score = 277 bits (707), Expect = 9e-074
Identities = 138/212 (65%), Positives = 165/212 (77%), Gaps = 4/212 (1%)
Frame = +1
Query: 43 PALSLSLSSMAIASEKEASDVSAVAQKRWNLNDFDIGKPLGRGKFGHVYLAREKRSNHIV 222
PA S + S AS ++ D +++W L DFDIG+PLG+GKFG+VYLARE++S I+
Sbjct: 94 PAASGNDSEKEQASLQKTEDTK---KRQWTLEDFDIGRPLGKGKFGNVYLARERQSKFIL 150
Query: 223 ALKVLFKTQLQQSQVEHQLRREVEIQSHLLNPNILRLYGYFYDQKRVYLILEYAARGELY 402
ALKVLFKTQL+++ VEHQLRREVEIQSHL +PNILRLYGYF+D RVYLILEYA G +Y
Sbjct: 151 ALKVLFKTQLEKANVEHQLRREVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVY 210
Query: 403 KELQKCKYFSERRAATYVAFLARALIYCHGKHVIHRDIKPENLLIGAQGELKVADFGWSV 582
+ELQK F E+R ATY+ LA AL YCH K VIHRDIKPENLL+G+ GELK+ADFGWSV
Sbjct: 211 RELQKLSKFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGSNGELKIADFGWSV 270
Query: 583 HT-FNRRRTMCGTLDYLPPEMVESVEHDASVE 675
H +RR TMCGTLDYLPPEM+E HD V+
Sbjct: 271 HAPSSRRTTMCGTLDYLPPEMIEGRMHDEKVD 302
>sp|A5GFW1|STK6_PIG Serine/threonine-protein kinase 6 OS=Sus scrofa GN=AURKA
PE=3 SV=1
Length = 402
Score = 272 bits (695), Expect = 2e-072
Identities = 133/200 (66%), Positives = 162/200 (81%), Gaps = 3/200 (1%)
Frame = +1
Query: 79 ASEKEASDVSAVAQKRWNLNDFDIGKPLGRGKFGHVYLAREKRSNHIVALKVLFKTQLQQ 258
A+ K+ ++ S +++W L DF+IG+PLG+GKFG+VYLAREK+S I+ALKVLFKTQL++
Sbjct: 114 AASKQKNEES--KKRQWALEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKTQLEK 171
Query: 259 SQVEHQLRREVEIQSHLLNPNILRLYGYFYDQKRVYLILEYAARGELYKELQKCKYFSER 438
+ VEHQLRREVEIQSHL +PNILRLYGYF+D RVYLILEYA G +Y+ELQK F E+
Sbjct: 172 AGVEHQLRREVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGAVYRELQKLSKFDEQ 231
Query: 439 RAATYVAFLARALIYCHGKHVIHRDIKPENLLIGAQGELKVADFGWSVHT-FNRRRTMCG 615
R ATY+ LA AL YCH K VIHRDIKPENLL+G+ GELK+ADFGWSVH +RR T+CG
Sbjct: 232 RTATYITELANALSYCHSKRVIHRDIKPENLLLGSAGELKIADFGWSVHAPSSRRTTLCG 291
Query: 616 TLDYLPPEMVESVEHDASVE 675
TLDYLPPEM+E HD V+
Sbjct: 292 TLDYLPPEMIEGRMHDEKVD 311
>sp|P59241|STK6_RAT Serine/threonine-protein kinase 6 OS=Rattus norvegicus
GN=Aurka PE=1 SV=1
Length = 397
Score = 272 bits (695), Expect = 2e-072
Identities = 133/202 (65%), Positives = 159/202 (78%), Gaps = 4/202 (1%)
Frame = +1
Query: 82 SEKEASDVSAV---AQKRWNLNDFDIGKPLGRGKFGHVYLAREKRSNHIVALKVLFKTQL 252
SEKE + + +++W L DFDIG+PLG+GKFG+VYLAREK+S I+ALKVLFK QL
Sbjct: 103 SEKEQTSIQKTEDSKKRQWTLEDFDIGRPLGKGKFGNVYLAREKQSKFILALKVLFKVQL 162
Query: 253 QQSQVEHQLRREVEIQSHLLNPNILRLYGYFYDQKRVYLILEYAARGELYKELQKCKYFS 432
+++ VEHQLRREVEIQSHL +PNILRLYGYF+D RVYLILEYA G +Y+ELQK F
Sbjct: 163 EKAGVEHQLRREVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFD 222
Query: 433 ERRAATYVAFLARALIYCHGKHVIHRDIKPENLLIGAQGELKVADFGWSVHT-FNRRRTM 609
E+R ATY+ LA AL YCH K VIHRDIKPENLL+G+ GELK+ADFGWSVH +RR T+
Sbjct: 223 EQRTATYITELANALSYCHSKRVIHRDIKPENLLLGSNGELKIADFGWSVHAPSSRRTTL 282
Query: 610 CGTLDYLPPEMVESVEHDASVE 675
CGTLDY PPEM+E HD V+
Sbjct: 283 CGTLDYQPPEMIEGRMHDEKVD 304
>sp|Q91820|STK6_XENLA Serine/threonine-protein kinase 6 OS=Xenopus laevis
GN=aurka PE=1 SV=1
Length = 407
Score = 272 bits (695), Expect = 2e-072
Identities = 128/187 (68%), Positives = 158/187 (84%), Gaps = 1/187 (0%)
Frame = +1
Query: 118 QKRWNLNDFDIGKPLGRGKFGHVYLAREKRSNHIVALKVLFKTQLQQSQVEHQLRREVEI 297
+K+W L DF+IG+PLG+GKFG+VYLARE+ S I+ALKVLFK+QL+++ VEHQLRREVEI
Sbjct: 132 KKQWCLEDFEIGRPLGKGKFGNVYLARERESKFILALKVLFKSQLEKAGVEHQLRREVEI 191
Query: 298 QSHLLNPNILRLYGYFYDQKRVYLILEYAARGELYKELQKCKYFSERRAATYVAFLARAL 477
QSHL +PNILRLYGYF+D RVYLIL+YA GEL++ELQKC F ++R+A Y+ LA AL
Sbjct: 192 QSHLRHPNILRLYGYFHDASRVYLILDYAPGGELFRELQKCTRFDDQRSAMYIKQLAEAL 251
Query: 478 IYCHGKHVIHRDIKPENLLIGAQGELKVADFGWSVHT-FNRRRTMCGTLDYLPPEMVESV 654
+YCH K VIHRDIKPENLL+G+ GELK+ADFGWSVH +RR T+CGTLDYLPPEM+E
Sbjct: 252 LYCHSKKVIHRDIKPENLLLGSNGELKIADFGWSVHAPSSRRTTLCGTLDYLPPEMIEGR 311
Query: 655 EHDASVE 675
HD +V+
Sbjct: 312 MHDETVD 318
>sp|Q91819|STK6L_XENLA Serine/threonine-protein kinase Eg2-like OS=Xenopus
laevis PE=2 SV=2
Length = 408
Score = 272 bits (694), Expect = 3e-072
Identities = 128/187 (68%), Positives = 157/187 (83%), Gaps = 1/187 (0%)
Frame = +1
Query: 118 QKRWNLNDFDIGKPLGRGKFGHVYLAREKRSNHIVALKVLFKTQLQQSQVEHQLRREVEI 297
+K+W L DF+IG+PLG+GKFG+VYLARE+ S I+ALKVLFK+QL+++ VEHQLRREVEI
Sbjct: 132 KKQWCLEDFEIGRPLGKGKFGNVYLARERESKFILALKVLFKSQLEKAGVEHQLRREVEI 191
Query: 298 QSHLLNPNILRLYGYFYDQKRVYLILEYAARGELYKELQKCKYFSERRAATYVAFLARAL 477
QSHL +PNILRLYGYF+D RVYLIL+YA GEL++ELQKC F ++R+A Y+ LA AL
Sbjct: 192 QSHLRHPNILRLYGYFHDASRVYLILDYAPGGELFRELQKCTRFDDQRSALYIKQLAEAL 251
Query: 478 IYCHGKHVIHRDIKPENLLIGAQGELKVADFGWSVHT-FNRRRTMCGTLDYLPPEMVESV 654
+YCH K VIHRDIKPENLL+G+ GELK+ADFGWSVH +RR T+CGTLDYLPPEM+E
Sbjct: 252 LYCHSKKVIHRDIKPENLLLGSNGELKIADFGWSVHAPSSRRTTLCGTLDYLPPEMIEGR 311
Query: 655 EHDASVE 675
HD V+
Sbjct: 312 MHDEKVD 318
>sp|Q7YRC6|AURKB_BOVIN Serine/threonine-protein kinase 12 OS=Bos taurus GN=AURKB
PE=2 SV=1
Length = 344
Score = 271 bits (691), Expect = 7e-072
Identities = 128/197 (64%), Positives = 163/197 (82%), Gaps = 1/197 (0%)
Frame = +1
Query: 88 KEASDVSAVAQKRWNLNDFDIGKPLGRGKFGHVYLAREKRSNHIVALKVLFKTQLQQSQV 267
+ +S + ++ + ++DF+IG+PLG+GKFG+VYLAREK+S+ IVALKVLFK+Q+++ V
Sbjct: 59 ENSSGTPNIPKRSFTIDDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGV 118
Query: 268 EHQLRREVEIQSHLLNPNILRLYGYFYDQKRVYLILEYAARGELYKELQKCKYFSERRAA 447
EHQLRRE+EIQ+HL +PNILRLY YFYD++R+YLILEYA RGELYKELQK + F E+R A
Sbjct: 119 EHQLRREIEIQAHLQHPNILRLYNYFYDRRRIYLILEYAPRGELYKELQKSRTFDEQRTA 178
Query: 448 TYVAFLARALIYCHGKHVIHRDIKPENLLIGAQGELKVADFGWSVHTFN-RRRTMCGTLD 624
T + LA AL YCH K VIHRDIKPENLL+G +GELK+ADFGWSVH + RR+TMCGTLD
Sbjct: 179 TIMEELADALTYCHAKKVIHRDIKPENLLLGLRGELKIADFGWSVHAPSLRRKTMCGTLD 238
Query: 625 YLPPEMVESVEHDASVE 675
YLPPEM+E H+ V+
Sbjct: 239 YLPPEMIEGRTHNEKVD 255
>sp|Q96GD4|AURKB_HUMAN Serine/threonine-protein kinase 12 OS=Homo sapiens
GN=AURKB PE=1 SV=2
Length = 344
Score = 271 bits (691), Expect = 7e-072
Identities = 129/197 (65%), Positives = 163/197 (82%), Gaps = 1/197 (0%)
Frame = +1
Query: 88 KEASDVSAVAQKRWNLNDFDIGKPLGRGKFGHVYLAREKRSNHIVALKVLFKTQLQQSQV 267
+ +S + + + ++DF+IG+PLG+GKFG+VYLAREK+S+ IVALKVLFK+Q+++ V
Sbjct: 59 ENSSGTPDILTRHFTIDDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGV 118
Query: 268 EHQLRREVEIQSHLLNPNILRLYGYFYDQKRVYLILEYAARGELYKELQKCKYFSERRAA 447
EHQLRRE+EIQ+HL +PNILRLY YFYD++R+YLILEYA RGELYKELQK F E+R A
Sbjct: 119 EHQLRREIEIQAHLHHPNILRLYNYFYDRRRIYLILEYAPRGELYKELQKSCTFDEQRTA 178
Query: 448 TYVAFLARALIYCHGKHVIHRDIKPENLLIGAQGELKVADFGWSVHTFN-RRRTMCGTLD 624
T + LA AL+YCHGK VIHRDIKPENLL+G +GELK+ADFGWSVH + RR+TMCGTLD
Sbjct: 179 TIMEELADALMYCHGKKVIHRDIKPENLLLGLKGELKIADFGWSVHAPSLRRKTMCGTLD 238
Query: 625 YLPPEMVESVEHDASVE 675
YLPPEM+E H+ V+
Sbjct: 239 YLPPEMIEGRMHNEKVD 255
>sp|Q54WX4|AURK_DICDI Probable serine/threonine-protein kinase aurK
OS=Dictyostelium discoideum GN=aurK PE=1 SV=1
Length = 384
Score = 270 bits (690), Expect = 9e-072
Identities = 132/209 (63%), Positives = 162/209 (77%), Gaps = 1/209 (0%)
Frame = +1
Query: 52 SLSLSSMAIASEKEASDVSAVAQKRWNLNDFDIGKPLGRGKFGHVYLAREKRSNHIVALK 231
S S SS + +S +S +V +K+W ++DFDIGK LG G+FGHVYLAREK+S IVALK
Sbjct: 80 SSSSSSSSSSSSSSSSSSQSVPKKKWCIDDFDIGKLLGMGRFGHVYLAREKKSQFIVALK 139
Query: 232 VLFKTQLQQSQVEHQLRREVEIQSHLLNPNILRLYGYFYDQKRVYLILEYAARGELYKEL 411
VLFK QLQ +EHQLRRE+EIQSHL +PNILRL+GYFYD KRV+LI+E+A GE +KEL
Sbjct: 140 VLFKNQLQTHNIEHQLRREIEIQSHLRHPNILRLFGYFYDDKRVFLIIEFAKGGECFKEL 199
Query: 412 QKCKYFSERRAATYVAFLARALIYCHGKHVIHRDIKPENLLIGAQGELKVADFGWSVHTF 591
QK F+E+ AATY +A AL YCH KHVIHRDIKPENLLIG GE+K+ADFGWSVH
Sbjct: 200 QKVGSFNEQTAATYTLQIADALRYCHSKHVIHRDIKPENLLIGVGGEIKIADFGWSVHAP 259
Query: 592 N-RRRTMCGTLDYLPPEMVESVEHDASVE 675
N +R T CGTL+YLPPE++E +D + +
Sbjct: 260 NTKRSTFCGTLEYLPPEVIEKKGYDQTAD 288
>sp|Q6DE08|AUKBA_XENLA Serine/threonine-protein kinase 12-A OS=Xenopus laevis
GN=aurkb-a PE=1 SV=1
Length = 361
Score = 270 bits (689), Expect = 1e-071
Identities = 133/215 (61%), Positives = 172/215 (80%), Gaps = 4/215 (1%)
Frame = +1
Query: 43 PALSLSLSSMAIASEKEASDVSAVAQ---KRWNLNDFDIGKPLGRGKFGHVYLAREKRSN 213
P+ S S+ S + S +A+A+ +++ ++DFDIG+PLG+GKFG+VYLAREK++
Sbjct: 57 PSASSSVPGRVAVSTEMPSQNTALAEMPKRKFTIDDFDIGRPLGKGKFGNVYLAREKQNK 116
Query: 214 HIVALKVLFKTQLQQSQVEHQLRREVEIQSHLLNPNILRLYGYFYDQKRVYLILEYAARG 393
I+ALKVLFK+QL++ VEHQLRRE+EIQSHL +PNILR+Y YF+D+KR+YL+LE+A RG
Sbjct: 117 FIMALKVLFKSQLEKEGVEHQLRREIEIQSHLRHPNILRMYNYFHDRKRIYLMLEFAPRG 176
Query: 394 ELYKELQKCKYFSERRAATYVAFLARALIYCHGKHVIHRDIKPENLLIGAQGELKVADFG 573
ELYKELQK F E+R+AT++ LA AL YCH + VIHRDIKPENLL+G +GELK+ADFG
Sbjct: 177 ELYKELQKHGRFDEQRSATFMEELADALHYCHERKVIHRDIKPENLLMGYKGELKIADFG 236
Query: 574 WSVHTFN-RRRTMCGTLDYLPPEMVESVEHDASVE 675
WSVH + RRRTMCGTLDYLPPEM+E HD V+
Sbjct: 237 WSVHAPSLRRRTMCGTLDYLPPEMIEGKTHDEKVD 271
>sp|Q6GPL3|AUKBB_XENLA Serine/threonine-protein kinase 12-B OS=Xenopus laevis
GN=aurkb-b PE=2 SV=1
Length = 368
Score = 270 bits (689), Expect = 1e-071
Identities = 134/215 (62%), Positives = 171/215 (79%), Gaps = 4/215 (1%)
Frame = +1
Query: 43 PALSLSLSSMAIASEKEASDVSAVAQ---KRWNLNDFDIGKPLGRGKFGHVYLAREKRSN 213
PA S S+ AS +A+A+ +++ ++DFDIG+PLG+GKFG+VYLAREK++
Sbjct: 64 PAASSSVPGRVALGTDVASHNTALAEAPKRKFTIDDFDIGRPLGKGKFGNVYLAREKQNK 123
Query: 214 HIVALKVLFKTQLQQSQVEHQLRREVEIQSHLLNPNILRLYGYFYDQKRVYLILEYAARG 393
I+ALKVLFK+QL++ VEHQLRRE+EIQSHL +PNILR+Y YF+D+KR+YL+LE+A RG
Sbjct: 124 FIMALKVLFKSQLEKEGVEHQLRREIEIQSHLRHPNILRMYNYFHDRKRIYLMLEFAPRG 183
Query: 394 ELYKELQKCKYFSERRAATYVAFLARALIYCHGKHVIHRDIKPENLLIGAQGELKVADFG 573
ELYKELQK F E+R+AT++ LA AL YCH + VIHRDIKPENLL+G +GELK+ADFG
Sbjct: 184 ELYKELQKHGRFDEQRSATFMEELADALQYCHERKVIHRDIKPENLLMGYKGELKIADFG 243
Query: 574 WSVHTFN-RRRTMCGTLDYLPPEMVESVEHDASVE 675
WSVH + RRRTMCGTLDYLPPEM+E HD V+
Sbjct: 244 WSVHAPSLRRRTMCGTLDYLPPEMIEGKTHDEKVD 278
>sp|Q2TA06|STK6_BOVIN Serine/threonine-protein kinase 6 OS=Bos taurus GN=AURKA
PE=2 SV=1
Length = 402
Score = 270 bits (688), Expect = 1e-071
Identities = 129/187 (68%), Positives = 154/187 (82%), Gaps = 1/187 (0%)
Frame = +1
Query: 118 QKRWNLNDFDIGKPLGRGKFGHVYLAREKRSNHIVALKVLFKTQLQQSQVEHQLRREVEI 297
+++W L DF+IG+PLG+GKFG+VYLAREK+S I+ALKVLFK QL+++ VEHQLRREVEI
Sbjct: 125 KRQWALEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRREVEI 184
Query: 298 QSHLLNPNILRLYGYFYDQKRVYLILEYAARGELYKELQKCKYFSERRAATYVAFLARAL 477
QSHL +PNILRLYGYF+D RVYLILEYA G +Y+ELQK F E+R ATY+ LA AL
Sbjct: 185 QSHLRHPNILRLYGYFHDATRVYLILEYAPLGAVYRELQKLSKFDEQRTATYITELANAL 244
Query: 478 IYCHGKHVIHRDIKPENLLIGAQGELKVADFGWSVHT-FNRRRTMCGTLDYLPPEMVESV 654
YCH K VIHRDIKPENLL+G+ GELK+ADFGWSVH +RR T+CGTLDYLPPEM+E
Sbjct: 245 SYCHSKRVIHRDIKPENLLLGSAGELKIADFGWSVHAPSSRRTTLCGTLDYLPPEMIEGR 304
Query: 655 EHDASVE 675
HD V+
Sbjct: 305 MHDEKVD 311
>sp|O14965|STK6_HUMAN Serine/threonine-protein kinase 6 OS=Homo sapiens GN=AURKA
PE=1 SV=2
Length = 403
Score = 270 bits (688), Expect = 1e-071
Identities = 129/187 (68%), Positives = 154/187 (82%), Gaps = 1/187 (0%)
Frame = +1
Query: 118 QKRWNLNDFDIGKPLGRGKFGHVYLAREKRSNHIVALKVLFKTQLQQSQVEHQLRREVEI 297
+++W L DF+IG+PLG+GKFG+VYLAREK+S I+ALKVLFK QL+++ VEHQLRREVEI
Sbjct: 125 KRQWALEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRREVEI 184
Query: 298 QSHLLNPNILRLYGYFYDQKRVYLILEYAARGELYKELQKCKYFSERRAATYVAFLARAL 477
QSHL +PNILRLYGYF+D RVYLILEYA G +Y+ELQK F E+R ATY+ LA AL
Sbjct: 185 QSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITELANAL 244
Query: 478 IYCHGKHVIHRDIKPENLLIGAQGELKVADFGWSVHT-FNRRRTMCGTLDYLPPEMVESV 654
YCH K VIHRDIKPENLL+G+ GELK+ADFGWSVH +RR T+CGTLDYLPPEM+E
Sbjct: 245 SYCHSKRVIHRDIKPENLLLGSAGELKIADFGWSVHAPSSRRTTLCGTLDYLPPEMIEGR 304
Query: 655 EHDASVE 675
HD V+
Sbjct: 305 MHDEKVD 311
>sp|A4IGM9|AURKB_XENTR Serine/threonine-protein kinase 12 OS=Xenopus tropicalis
GN=aurkb PE=2 SV=1
Length = 360
Score = 269 bits (686), Expect = 2e-071
Identities = 132/215 (61%), Positives = 172/215 (80%), Gaps = 4/215 (1%)
Frame = +1
Query: 43 PALSLSLSSMAIASEKEASDVSAVAQ---KRWNLNDFDIGKPLGRGKFGHVYLAREKRSN 213
P+ S S+ S +S +A+A+ +++ ++DFDIG+PLG+GKFG+VYLAR+K++
Sbjct: 57 PSASSSVPGRVAVSMDASSQNTALAELPKRKFTIDDFDIGRPLGKGKFGNVYLARDKQNK 116
Query: 214 HIVALKVLFKTQLQQSQVEHQLRREVEIQSHLLNPNILRLYGYFYDQKRVYLILEYAARG 393
I+ALKVLFK+QL++ VEHQLRRE+EIQSHL +PNILR+Y YF+D+KR+YL+LE+A RG
Sbjct: 117 FIMALKVLFKSQLEKEGVEHQLRREIEIQSHLRHPNILRMYNYFHDRKRIYLMLEFAPRG 176
Query: 394 ELYKELQKCKYFSERRAATYVAFLARALIYCHGKHVIHRDIKPENLLIGAQGELKVADFG 573
ELYKELQK F E+R+AT++ LA AL YCH + VIHRDIKPENLL+G +GELK+ADFG
Sbjct: 177 ELYKELQKHGRFDEQRSATFMEELADALQYCHERKVIHRDIKPENLLMGYKGELKIADFG 236
Query: 574 WSVHTFN-RRRTMCGTLDYLPPEMVESVEHDASVE 675
WSVH + RRRTMCGTLDYLPPEM+E HD V+
Sbjct: 237 WSVHAPSLRRRTMCGTLDYLPPEMIEGKTHDEKVD 271
>sp|O70126|AURKB_MOUSE Serine/threonine-protein kinase 12 OS=Mus musculus
GN=Aurkb PE=1 SV=1
Length = 345
Score = 265 bits (676), Expect = 4e-070
Identities = 128/201 (63%), Positives = 164/201 (81%), Gaps = 3/201 (1%)
Frame = +1
Query: 82 SEKEASDVSAVAQKR--WNLNDFDIGKPLGRGKFGHVYLAREKRSNHIVALKVLFKTQLQ 255
++ + S S +Q + + +++F+IG+PLG+GKFG+VYLAREK+S IVALK+LFK+Q++
Sbjct: 60 NKSQGSTASQGSQNKQPFTIDNFEIGRPLGKGKFGNVYLAREKKSRFIVALKILFKSQIE 119
Query: 256 QSQVEHQLRREVEIQSHLLNPNILRLYGYFYDQKRVYLILEYAARGELYKELQKCKYFSE 435
+ VEHQLRRE+EIQ+HL +PNIL+LY YFYDQ+R+YLILEYA RGELYKELQK + F E
Sbjct: 120 KEGVEHQLRREIEIQAHLKHPNILQLYNYFYDQQRIYLILEYAPRGELYKELQKSRTFDE 179
Query: 436 RRAATYVAFLARALIYCHGKHVIHRDIKPENLLIGAQGELKVADFGWSVHTFN-RRRTMC 612
+R AT + L+ AL YCH K VIHRDIKPENLL+G QGELK+ADFGWSVH + RR+TMC
Sbjct: 180 QRTATIMEELSDALTYCHKKKVIHRDIKPENLLLGLQGELKIADFGWSVHAPSLRRKTMC 239
Query: 613 GTLDYLPPEMVESVEHDASVE 675
GTLDYLPPEM+E H+ V+
Sbjct: 240 GTLDYLPPEMIEGRMHNEMVD 260
>sp|O55099|AURKB_RAT Serine/threonine-protein kinase 12 OS=Rattus norvegicus
GN=Aurkb PE=1 SV=1
Length = 343
Score = 265 bits (675), Expect = 5e-070
Identities = 130/210 (61%), Positives = 166/210 (79%), Gaps = 7/210 (3%)
Frame = +1
Query: 67 SMAIASEKEASDVSAVA------QKRWNLNDFDIGKPLGRGKFGHVYLAREKRSNHIVAL 228
S A+ +K + A A ++ + +++F+IG+PLG+GKFG+VYLAREK+S IVAL
Sbjct: 49 STAVPGQKLTENKGATALQGSQSRQPFTIDNFEIGRPLGKGKFGNVYLAREKKSRFIVAL 108
Query: 229 KVLFKTQLQQSQVEHQLRREVEIQSHLLNPNILRLYGYFYDQKRVYLILEYAARGELYKE 408
K+LFK+Q+++ VEHQLRRE+EIQ+HL +PNIL+LY YFYDQ+R+YLILEYA RGELYKE
Sbjct: 109 KILFKSQIEKEGVEHQLRREIEIQAHLKHPNILQLYNYFYDQQRIYLILEYAPRGELYKE 168
Query: 409 LQKCKYFSERRAATYVAFLARALIYCHGKHVIHRDIKPENLLIGAQGELKVADFGWSVHT 588
LQK F E+R AT + L+ AL+YCH K VIHRDIKPENLL+G QGELK+ADFGWSVH
Sbjct: 169 LQKSGTFDEQRTATIMEELSDALMYCHKKKVIHRDIKPENLLLGLQGELKIADFGWSVHA 228
Query: 589 FN-RRRTMCGTLDYLPPEMVESVEHDASVE 675
+ RR+TMCGTLDYLPPEM+E H+ V+
Sbjct: 229 PSLRRKTMCGTLDYLPPEMIEGRMHNEMVD 258
>sp|Q9UQB9|AURKC_HUMAN Serine/threonine-protein kinase 13 OS=Homo sapiens
GN=AURKC PE=2 SV=1
Length = 309
Score = 264 bits (673), Expect = 8e-070
Identities = 128/199 (64%), Positives = 161/199 (80%), Gaps = 1/199 (0%)
Frame = +1
Query: 82 SEKEASDVSAVAQKRWNLNDFDIGKPLGRGKFGHVYLAREKRSNHIVALKVLFKTQLQQS 261
+ + A S+ A +R ++DF+IG+PLG+GKFG+VYLAR K S+ IVALKVLFK+Q+++
Sbjct: 23 ANQTAQQPSSPAMRRLTVDDFEIGRPLGKGKFGNVYLARLKESHFIVALKVLFKSQIEKE 82
Query: 262 QVEHQLRREVEIQSHLLNPNILRLYGYFYDQKRVYLILEYAARGELYKELQKCKYFSERR 441
+EHQLRRE+EIQ+HL +PNILRLY YF+D +RVYLILEYA RGELYKELQK + E+R
Sbjct: 83 GLEHQLRREIEIQAHLQHPNILRLYNYFHDARRVYLILEYAPRGELYKELQKSEKLDEQR 142
Query: 442 AATYVAFLARALIYCHGKHVIHRDIKPENLLIGAQGELKVADFGWSVHTFN-RRRTMCGT 618
AT + LA AL YCH K VIHRDIKPENLL+G +GE+K+ADFGWSVHT + RR+TMCGT
Sbjct: 143 TATIIEELADALTYCHDKKVIHRDIKPENLLLGFRGEVKIADFGWSVHTPSLRRKTMCGT 202
Query: 619 LDYLPPEMVESVEHDASVE 675
LDYLPPEM+E +D V+
Sbjct: 203 LDYLPPEMIEGRTYDEKVD 221
>sp|O64629|AUR3_ARATH Serine/threonine-protein kinase Aurora-3 OS=Arabidopsis
thaliana GN=AUR3 PE=2 SV=1
Length = 288
Score = 255 bits (651), Expect = 3e-067
Identities = 118/198 (59%), Positives = 162/198 (81%)
Frame = +1
Query: 82 SEKEASDVSAVAQKRWNLNDFDIGKPLGRGKFGHVYLAREKRSNHIVALKVLFKTQLQQS 261
S+K + +K+W+L DF+IG+PLG+GKFG VYLARE +S +IVALKV+FK Q+++
Sbjct: 2 SKKSTESDAGNTEKQWSLADFEIGRPLGKGKFGRVYLAREAKSKYIVALKVIFKEQIEKY 61
Query: 262 QVEHQLRREVEIQSHLLNPNILRLYGYFYDQKRVYLILEYAARGELYKELQKCKYFSERR 441
++ HQLRRE+EIQ+ L +PNILRL+G+F+D +R++LILEYA GELY L++ + +E++
Sbjct: 62 KIHHQLRREMEIQTSLRHPNILRLFGWFHDNERIFLILEYAHGGELYGVLKQNGHLTEQQ 121
Query: 442 AATYVAFLARALIYCHGKHVIHRDIKPENLLIGAQGELKVADFGWSVHTFNRRRTMCGTL 621
AATY+A L++AL YCHGK VIHRDIKPENLL+ +G LK+ADFGWSV + N+R+TMCGTL
Sbjct: 122 AATYIASLSQALAYCHGKCVIHRDIKPENLLLDHEGRLKIADFGWSVQSSNKRKTMCGTL 181
Query: 622 DYLPPEMVESVEHDASVE 675
DYL PEMVE+ +HD +V+
Sbjct: 182 DYLAPEMVENRDHDYAVD 199
Database: UniProt/SwissProt
Posted date: Sat Aug 07 14:36:18 2010
Number of letters in database: 182,829,261
Number of sequences in database: 518,415
Lambda K H
0.267 0.041 0.140
Gapped
Lambda K H
0.267 0.041 0.140
Matrix: blosum62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 164,931,892,944
Number of Sequences: 518415
Number of Extensions: 164931892944
Number of Successful Extensions: 1021520109
Number of sequences better than 0.0: 0
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