BLASTX 7.6.2
Query= UN43211 /QuerySize=659
(658 letters)
Database: UniProt/SwissProt;
518,415 sequences; 182,829,261 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q9ST43|PH1_ARATH Pleckstrin homology domain-containing protei... 275 2e-073
sp|Q80TI1|PKHH1_MOUSE Pleckstrin homology domain-containing fami... 69 2e-011
sp|Q86IV4|Y4775_DICDI PH domain-containing protein DDB_G0274775 ... 67 7e-011
sp|Q9ULM0|PKHH1_HUMAN Pleckstrin homology domain-containing fami... 64 6e-010
sp|Q9W5D0|Y34F_DROME Uncharacterized protein CG42248 OS=Drosophi... 62 4e-009
sp|Q8N264|RHG24_HUMAN Rho GTPase-activating protein 24 OS=Homo s... 60 8e-009
sp|Q00IB7|PKHH1_DANRE Pleckstrin homology domain-containing fami... 59 2e-008
sp|Q559T8|Y0701_DICDI Probable serine/threonine-protein kinase D... 59 3e-008
sp|Q8C115|PKHH2_MOUSE Pleckstrin homology domain-containing fami... 58 4e-008
sp|Q5U2Z7|RHG24_RAT Rho GTPase-activating protein 24 OS=Rattus n... 58 4e-008
sp|Q8IVE3|PKHH2_HUMAN Pleckstrin homology domain-containing fami... 57 7e-008
sp|Q8C4V1|RHG24_MOUSE Rho GTPase-activating protein 24 OS=Mus mu... 55 3e-007
sp|Q80YW0|CYH4_MOUSE Cytohesin-4 OS=Mus musculus GN=Cyth4 PE=2 SV=1 55 3e-007
sp|Q8BL80|RHG22_MOUSE Rho GTPase-activating protein 22 OS=Mus mu... 54 6e-007
sp|Q9UIA0|CYH4_HUMAN Cytohesin-4 OS=Homo sapiens GN=CYTH4 PE=1 SV=1 54 8e-007
sp|Q54KA7|SECG_DICDI Ankyrin repeat, PH and SEC7 domain containi... 54 8e-007
sp|O08967|CYH3_MOUSE Cytohesin-3 OS=Mus musculus GN=Cyth3 PE=1 SV=1 54 1e-006
sp|Q76MY7|CYH2_CERAE Cytohesin-2 OS=Cercopithecus aethiops GN=CY... 52 2e-006
sp|Q7Z5H3|RHG22_HUMAN Rho GTPase-activating protein 22 OS=Homo s... 52 4e-006
>sp|Q9ST43|PH1_ARATH Pleckstrin homology domain-containing protein 1
OS=Arabidopsis thaliana GN=PH1 PE=2 SV=2
Length = 145
Score = 275 bits (703), Expect = 2e-073
Identities = 128/144 (88%), Positives = 137/144 (95%)
Frame = +1
Query: 64 MENLWRIATGQDPNRQDYEGIEFWSNPERSGWLTKQGDYIKTWRRRWFVLKRGKLLWFKD 243
ME++WRIATGQDP+R+DYEGIEFWSNPERSGWLTKQGDYIKTWRRRWFVLKRGKLLWFKD
Sbjct: 1 MESIWRIATGQDPSREDYEGIEFWSNPERSGWLTKQGDYIKTWRRRWFVLKRGKLLWFKD 60
Query: 244 QSGALTRGSVPRGVISVGDCLTVKGAEDVVNKAFAFEISSGNVTMFFVADNDKEKEEWIN 423
Q+ A RGS PRGVISVGDCLTVKGAEDVVNK FAFE+SSG+ TMFF+ADN+KEKEEWIN
Sbjct: 61 QAAAGIRGSTPRGVISVGDCLTVKGAEDVVNKPFAFELSSGSYTMFFIADNEKEKEEWIN 120
Query: 424 SIGRSIVQHSRSVTDSEVLDYDQR 495
SIGRSIVQHSRSVTDSEVLDYD R
Sbjct: 121 SIGRSIVQHSRSVTDSEVLDYDHR 144
>sp|Q80TI1|PKHH1_MOUSE Pleckstrin homology domain-containing family H member 1
OS=Mus musculus GN=Plekhh1 PE=2 SV=2
Length = 1356
Score = 69 bits (167), Expect = 2e-011
Identities = 35/93 (37%), Positives = 56/93 (60%), Gaps = 9/93 (9%)
Frame = +1
Query: 145 ERSGWLTKQGDYIKTWRRRWFVLKRGKLLWFKDQSGALTRGSVPRGVISVGD-CLTVKGA 321
E+SG+L K G +KTW+RRWFVL++G++L++K S + + P+G + + C V+
Sbjct: 574 EKSGYLLKMGSRVKTWKRRWFVLRQGQILYYKSPSDVIRK---PQGQVDLNSHCQIVREE 630
Query: 322 EDVVNKAFAFEISSGNVTMFFVADNDKEKEEWI 420
E A F++ SGN T + A++ EEWI
Sbjct: 631 E-----AQTFQLISGNKTYYLTAESPSLLEEWI 658
>sp|Q86IV4|Y4775_DICDI PH domain-containing protein DDB_G0274775
OS=Dictyostelium discoideum GN=DDB_G0274775 PE=4 SV=1
Length = 458
Score = 67 bits (163), Expect = 7e-011
Identities = 36/101 (35%), Positives = 57/101 (56%), Gaps = 8/101 (7%)
Frame = +1
Query: 145 ERSGWLTKQGDYIKTWRRRWFVLKRGKLLWFKDQSGALTRGSV-PRGVISVGDCLTVKGA 321
+R GWLTKQG I+TWRRRWFVLK KL +FK ++G + G+I + VK
Sbjct: 17 DREGWLTKQGGSIRTWRRRWFVLKGKKLFYFK------SKGDIEATGLIELEQNSFVKEE 70
Query: 322 EDV-VNKAFAFEISSGNVTMFFVADNDKEKEEWINSIGRSI 441
+D K + F + + + A+ + + ++W+ SI R++
Sbjct: 71 KDKDKKKKYMFTVGTSKRVFYIFAETETDMKQWMESIKRNL 111
>sp|Q9ULM0|PKHH1_HUMAN Pleckstrin homology domain-containing family H member 1
OS=Homo sapiens GN=PLEKHH1 PE=2 SV=2
Length = 1364
Score = 64 bits (155), Expect = 6e-010
Identities = 32/93 (34%), Positives = 54/93 (58%), Gaps = 9/93 (9%)
Frame = +1
Query: 145 ERSGWLTKQGDYIKTWRRRWFVLKRGKLLWFKDQSGALTRGSVPRGVISVGD-CLTVKGA 321
E+SG+L K G +KTW+RRWFVL++G+++++K S + + P+G + + C V+G
Sbjct: 580 EKSGYLLKMGSQVKTWKRRWFVLRQGQIMYYKSPSDVIRK---PQGQVDLNSRCQIVRG- 635
Query: 322 EDVVNKAFAFEISSGNVTMFFVADNDKEKEEWI 420
+ F++ S T + AD+ EEWI
Sbjct: 636 ----EGSQTFQLISEKKTYYLTADSPSLLEEWI 664
>sp|Q9W5D0|Y34F_DROME Uncharacterized protein CG42248 OS=Drosophila melanogaster
GN=CG42248 PE=1 SV=4
Length = 1820
Score = 62 bits (148), Expect = 4e-009
Identities = 40/118 (33%), Positives = 59/118 (50%), Gaps = 10/118 (8%)
Frame = +1
Query: 145 ERSGWLTKQGDYIKTWRRRWFVLKRGKLLWFKDQSGALTRGSVPRGVISVGDCLTVKGAE 324
E+ G L K G +KTWR+RWFVLK G L ++K Q + P+G I + + + AE
Sbjct: 911 EKMGHLAKLGGKLKTWRKRWFVLKNGSLNYWKSQHDVQRK---PQGQIQLDEVCRINRAE 967
Query: 325 DVVNKAFAFEISSGNVTMFFVADNDKEKEEWINSIGRSIVQHSRSVTDSEVLDYDQRP 498
A FEI +G + AD+ ++WI + VQ R+ T + DQ+P
Sbjct: 968 G----ASTFEIDTGKKVYYLTADSHATMDDWIRVLQN--VQR-RNATKLLLSRDDQKP 1018
>sp|Q8N264|RHG24_HUMAN Rho GTPase-activating protein 24 OS=Homo sapiens
GN=ARHGAP24 PE=1 SV=2
Length = 748
Score = 60 bits (145), Expect = 8e-009
Identities = 33/106 (31%), Positives = 53/106 (50%), Gaps = 5/106 (4%)
Frame = +1
Query: 139 NPERSGWLTKQGDYIKTWRRRWFVLKRGKLLWFKDQSGALTRGSV--PRGVISVGDCLTV 312
N + GWL KQG ++KTW RWFVLK +L +FKD+ G++ P +S C
Sbjct: 19 NAIKCGWLRKQGGFVKTWHTRWFVLKGDQLYYFKDEDETKPLGTIFLPGNKVSEHPCNEE 78
Query: 313 KGAE---DVVNKAFAFEISSGNVTMFFVADNDKEKEEWINSIGRSI 441
+ +VV +++ + + +A + E+W+ SI R I
Sbjct: 79 NPGKFLFEVVPGGDRDRMTANHESYLLMASTQNDMEDWVKSIRRVI 124
>sp|Q00IB7|PKHH1_DANRE Pleckstrin homology domain-containing family H member 1
OS=Danio rerio GN=plekhh1 PE=2 SV=1
Length = 1433
Score = 59 bits (141), Expect = 2e-008
Identities = 33/113 (29%), Positives = 60/113 (53%), Gaps = 9/113 (7%)
Frame = +1
Query: 145 ERSGWLTKQGDYIKTWRRRWFVLKRGKLLWFKDQSGALTRGSVPRGVISVGDCLTVKGAE 324
E++G+L K G +K W+RRWF+L+ G++L++K S + + P+G + + + E
Sbjct: 645 EKTGYLLKMGSQVKAWKRRWFILRNGEILYYKSPSDVIRK---PQGQMELNSSCHIARGE 701
Query: 325 DVVNKAFAFEISSGNVTMFFVADNDKEKEEWINSIGRSI-VQHSRSVT-DSEV 477
A F++ + T + AD+ E+WI + + VQ S ++ D EV
Sbjct: 702 G----AQTFQLITEKKTFYLAADSPNILEDWIRVLQNVLKVQASGPISMDKEV 750
>sp|Q559T8|Y0701_DICDI Probable serine/threonine-protein kinase DDB_G0272282
OS=Dictyostelium discoideum GN=DDB_G0272282 PE=3 SV=1
Length = 2102
Score = 59 bits (140), Expect = 3e-008
Identities = 33/102 (32%), Positives = 58/102 (56%), Gaps = 11/102 (10%)
Frame = +1
Query: 136 SNPERSGWLTKQGDYIKTWRRRWFVLKRGKLLWFKDQSGALTRGSVPRGVISVGDCLTVK 315
+NP++SG+L K+G I++W++R+FVLK G + +FK QS G +P +G +
Sbjct: 123 NNPDKSGYLIKEGHVIRSWKKRYFVLKDGLIYYFKHQSDQEPTGMIP----VIGSQIKRI 178
Query: 316 GAEDVVNKAFAFEISSGNVTMF----FVADNDKEKEEWINSI 429
G + + F+F+I N T F A ++++ +WI +I
Sbjct: 179 GETE---RKFSFQIIPKNETFFPTFSIQARDEQDCNDWIKAI 217
>sp|Q8C115|PKHH2_MOUSE Pleckstrin homology domain-containing family H member 2
OS=Mus musculus GN=Plekhh2 PE=2 SV=2
Length = 1491
Score = 58 bits (139), Expect = 4e-008
Identities = 32/93 (34%), Positives = 52/93 (55%), Gaps = 9/93 (9%)
Frame = +1
Query: 145 ERSGWLTKQGDYIKTWRRRWFVLKRGKLLWFKDQSGALTRGSVPRGVISV-GDCLTVKGA 321
E+SG+L K +KTW+RRWFVLK G+LL++K S + + P+G I + C ++G
Sbjct: 704 EKSGYLLKMSVRVKTWKRRWFVLKGGELLYYKSPSDVIRK---PQGHIELSASCSILRG- 759
Query: 322 EDVVNKAFAFEISSGNVTMFFVADNDKEKEEWI 420
+ ++++ T + AD+ EEWI
Sbjct: 760 ----DNKQTVQLATEKHTYYLTADSPNILEEWI 788
>sp|Q5U2Z7|RHG24_RAT Rho GTPase-activating protein 24 OS=Rattus norvegicus
GN=Arhgap24 PE=2 SV=2
Length = 748
Score = 58 bits (139), Expect = 4e-008
Identities = 32/106 (30%), Positives = 52/106 (49%), Gaps = 5/106 (4%)
Frame = +1
Query: 139 NPERSGWLTKQGDYIKTWRRRWFVLKRGKLLWFKDQSGALTRGSV--PRGVISVGDCLTV 312
N + GWL KQG ++KTW RWFVLK +L +FKD+ G++ P + C
Sbjct: 18 NATKCGWLRKQGGFVKTWHTRWFVLKGDQLHYFKDEDETKPLGTIFLPGNKVIEHPCNEE 77
Query: 313 KGAE---DVVNKAFAFEISSGNVTMFFVADNDKEKEEWINSIGRSI 441
+ +VV +++ + + +A + E+W+ SI R I
Sbjct: 78 SPGKFLFEVVPGGERDRMTANHESYLLMASTQNDMEDWVKSIRRVI 123
>sp|Q8IVE3|PKHH2_HUMAN Pleckstrin homology domain-containing family H member 2
OS=Homo sapiens GN=PLEKHH2 PE=2 SV=2
Length = 1493
Score = 57 bits (137), Expect = 7e-008
Identities = 31/93 (33%), Positives = 52/93 (55%), Gaps = 9/93 (9%)
Frame = +1
Query: 145 ERSGWLTKQGDYIKTWRRRWFVLKRGKLLWFKDQSGALTRGSVPRGVISV-GDCLTVKGA 321
E+SG+L K +K+W+RRWFVLK G+LL++K S + + P+G I + C ++G
Sbjct: 705 EKSGYLLKMSGKVKSWKRRWFVLKGGELLYYKSPSDVIRK---PQGHIELSASCSILRG- 760
Query: 322 EDVVNKAFAFEISSGNVTMFFVADNDKEKEEWI 420
+ ++++ T + AD+ EEWI
Sbjct: 761 ----DNKQTVQLTTEKHTYYLTADSPNILEEWI 789
>sp|Q8C4V1|RHG24_MOUSE Rho GTPase-activating protein 24 OS=Mus musculus
GN=Arhgap24 PE=2 SV=2
Length = 747
Score = 55 bits (132), Expect = 3e-007
Identities = 33/103 (32%), Positives = 51/103 (49%), Gaps = 5/103 (4%)
Frame = +1
Query: 148 RSGWLTKQGDYIKTWRRRWFVLKRGKLLWFKDQSGALTRGSV---PRGVIS--VGDCLTV 312
+ GWL KQG ++KTW RWFVLK +L +FKD+ G++ VI +
Sbjct: 20 KCGWLRKQGGFVKTWHTRWFVLKGDQLYYFKDEDETKPLGTIFLHGNKVIEHPCNEENPG 79
Query: 313 KGAEDVVNKAFAFEISSGNVTMFFVADNDKEKEEWINSIGRSI 441
K DVV +++ + + +A + E+W+ SI R I
Sbjct: 80 KFLFDVVPGGERDRMTANHESYLLMASTQNDMEDWVKSIRRVI 122
>sp|Q80YW0|CYH4_MOUSE Cytohesin-4 OS=Mus musculus GN=Cyth4 PE=2 SV=1
Length = 393
Score = 55 bits (131), Expect = 3e-007
Identities = 30/73 (41%), Positives = 42/73 (57%), Gaps = 7/73 (9%)
Frame = +1
Query: 139 NPERSGWLTKQGDYIKTWRRRWFVLKRGKLLWFKDQSGALTRGSVPRGVISVGDCLTVKG 318
NP+R GWL K G +KTW+RRWF+L L +F+ T PRG+I + + L+V+
Sbjct: 259 NPDREGWLLKLGGRVKTWKRRWFILTDNCLYYFE-----FTTDKEPRGIIPL-ENLSVQK 312
Query: 319 AEDVVNKAFAFEI 357
ED K F E+
Sbjct: 313 VED-PKKPFCLEL 324
>sp|Q8BL80|RHG22_MOUSE Rho GTPase-activating protein 22 OS=Mus musculus
GN=Arhgap22 PE=1 SV=2
Length = 702
Score = 54 bits (129), Expect = 6e-007
Identities = 32/110 (29%), Positives = 55/110 (50%), Gaps = 17/110 (15%)
Frame = +1
Query: 148 RSGWLTKQGDYIKTWRRRWFVLKRGKLLWFKDQSGALTRGSVPRGVISVGDCLTVKGAED 327
++GWL KQ +K W++RWFVL+ +L ++KD+ S P+G IS+ + D
Sbjct: 46 KAGWLRKQRSIMKNWQQRWFVLRGDQLFYYKDKD-----ESKPQGFISLQGTQVTELLPD 100
Query: 328 VVNKA-FAFEISSGNVT-----------MFFVADNDKEKEEWINSIGRSI 441
+ FEI+ G T + +A + ++ E+W+ +I R I
Sbjct: 101 PEDPGKHLFEITPGGATEREKVPANPEALLLMASSQRDMEDWVQAIRRVI 150
>sp|Q9UIA0|CYH4_HUMAN Cytohesin-4 OS=Homo sapiens GN=CYTH4 PE=1 SV=1
Length = 394
Score = 54 bits (128), Expect = 8e-007
Identities = 29/73 (39%), Positives = 42/73 (57%), Gaps = 7/73 (9%)
Frame = +1
Query: 139 NPERSGWLTKQGDYIKTWRRRWFVLKRGKLLWFKDQSGALTRGSVPRGVISVGDCLTVKG 318
NP+R GWL K G +KTW+RRWF+L L +F+ T PRG+I + + L+V+
Sbjct: 259 NPDREGWLLKLGGRVKTWKRRWFILTDNCLYYFE-----FTTDKEPRGIIPL-ENLSVQK 312
Query: 319 AEDVVNKAFAFEI 357
+D K F E+
Sbjct: 313 VDD-PKKPFCLEL 324
>sp|Q54KA7|SECG_DICDI Ankyrin repeat, PH and SEC7 domain containing protein secG
OS=Dictyostelium discoideum GN=secG PE=2 SV=1
Length = 986
Score = 54 bits (128), Expect = 8e-007
Identities = 28/72 (38%), Positives = 43/72 (59%), Gaps = 3/72 (4%)
Frame = +1
Query: 64 MENLW-RIATGQDPNRQDYEGIEFWSNPERSGWLTKQGDYIKTWRRRWFVLKRGKLLWFK 240
MENL+ +I T + + + +G + + E+ GWLTKQG IKTW++RWF+L LL++K
Sbjct: 760 MENLYDKIVTNE--IKMERDGNQANQHVEKKGWLTKQGGRIKTWKKRWFILTANCLLYYK 817
Query: 241 DQSGALTRGSVP 276
G +P
Sbjct: 818 TPQDHEPCGIIP 829
>sp|O08967|CYH3_MOUSE Cytohesin-3 OS=Mus musculus GN=Cyth3 PE=1 SV=1
Length = 399
Score = 54 bits (127), Expect = 1e-006
Identities = 26/63 (41%), Positives = 38/63 (60%), Gaps = 6/63 (9%)
Frame = +1
Query: 139 NPERSGWLTKQGDYIKTWRRRWFVLKRGKLLWFKDQSGALTRGSVPRGVISVGDCLTVKG 318
NP+R GWL K G +KTW+RRWF+L L +F+ T PRG+I + + L+++
Sbjct: 264 NPDREGWLLKLGGRVKTWKRRWFILTDNCLYYFE-----YTTDKEPRGIIPL-ENLSIRE 317
Query: 319 AED 327
ED
Sbjct: 318 VED 320
>sp|Q76MY7|CYH2_CERAE Cytohesin-2 OS=Cercopithecus aethiops GN=CYTH2 PE=2 SV=1
Length = 399
Score = 52 bits (124), Expect = 2e-006
Identities = 22/52 (42%), Positives = 32/52 (61%)
Frame = +1
Query: 139 NPERSGWLTKQGDYIKTWRRRWFVLKRGKLLWFKDQSGALTRGSVPRGVISV 294
NP+R GWL K G +KTW+RRWF+L L +F+ + RG +P +S+
Sbjct: 259 NPDREGWLLKLGGRVKTWKRRWFILTDNCLYYFEYTTDKEPRGIIPLENLSI 310
>sp|Q7Z5H3|RHG22_HUMAN Rho GTPase-activating protein 22 OS=Homo sapiens
GN=ARHGAP22 PE=1 SV=1
Length = 698
Score = 52 bits (122), Expect = 4e-006
Identities = 33/112 (29%), Positives = 54/112 (48%), Gaps = 21/112 (18%)
Frame = +1
Query: 148 RSGWLTKQGDYIKTWRRRWFVLKRGKLLWFKDQSGALTRGSVPRGVISVGDCLTVK---G 318
++GWL KQ +K W++RWFVL+ +L ++KD+ P+G IS+ + G
Sbjct: 40 KAGWLKKQRSIMKNWQQRWFVLRGDQLFYYKDKDEI-----KPQGFISLQGTQVTELPPG 94
Query: 319 AEDVVNKAFAFEISSGNV-----------TMFFVADNDKEKEEWINSIGRSI 441
ED FEIS G + +A + ++ E+W+ +I R I
Sbjct: 95 PED--PGKHLFEISPGGAGEREKVPANPEALLLMASSQRDMEDWVQAIRRVI 144
Database: UniProt/SwissProt
Posted date: Sat Aug 07 14:36:18 2010
Number of letters in database: 182,829,261
Number of sequences in database: 518,415
Lambda K H
0.267 0.041 0.140
Gapped
Lambda K H
0.267 0.041 0.140
Matrix: blosum62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 164,931,892,944
Number of Sequences: 518415
Number of Extensions: 164931892944
Number of Successful Extensions: 1021520109
Number of sequences better than 0.0: 0
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