BLASTX 7.6.2
Query= UN44373 /QuerySize=862
(861 letters)
Database: UniProt/SwissProt;
518,415 sequences; 182,829,261 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q9BV68|RN126_HUMAN RING finger protein 126 OS=Homo sapiens GN... 82 4e-015
sp|Q0II22|RN126_BOVIN RING finger protein 126 OS=Bos taurus GN=R... 80 1e-014
sp|Q91YL2|RN126_MOUSE RING finger protein 126 OS=Mus musculus GN... 80 1e-014
sp|Q7T0Q3|R126A_XENLA RING finger protein 126-A OS=Xenopus laevi... 80 2e-014
sp|Q6IRP0|R126B_XENLA RING finger protein 126-B OS=Xenopus laevi... 80 2e-014
sp|Q6DIP3|RN126_XENTR RING finger protein 126 OS=Xenopus tropica... 79 5e-014
sp|Q9Y4L5|RN115_HUMAN E3 ubiquitin-protein ligase RNF115 OS=Homo... 76 2e-013
sp|Q9D0C1|RN115_MOUSE E3 ubiquitin-protein ligase RNF115 OS=Mus ... 76 2e-013
sp|Q5M974|RN181_XENTR E3 ubiquitin-protein ligase RNF181 OS=Xeno... 76 2e-013
sp|Q6GPV5|RN181_XENLA E3 ubiquitin-protein ligase RNF181 OS=Xeno... 76 3e-013
sp|Q9SPL2|CIP8_ARATH E3 ubiquitin-protein ligase CIP8 OS=Arabido... 73 3e-012
sp|Q80U04|PJA2_MOUSE E3 ubiquitin-protein ligase Praja-2 OS=Mus ... 64 9e-010
sp|Q63364|PJA2_RAT E3 ubiquitin-protein ligase Praja-2 OS=Rattus... 64 9e-010
sp|Q8NG27|PJA1_HUMAN E3 ubiquitin-protein ligase Praja-1 OS=Homo... 62 5e-009
sp|O55176|PJA1_MOUSE E3 ubiquitin-protein ligase Praja-1 OS=Mus ... 62 5e-009
sp|O43164|PJA2_HUMAN E3 ubiquitin-protein ligase Praja-2 OS=Homo... 60 2e-008
sp|Q5R4R1|PJA2_PONAB E3 ubiquitin-protein ligase Praja-2 OS=Pong... 60 2e-008
sp|Q0IJ20|RN145_XENTR RING finger protein 145 OS=Xenopus tropica... 59 3e-008
sp|A8WWR3|HRDL1_CAEBR E3 ubiquitin-protein ligase hrd-like prote... 59 4e-008
sp|P90859|HRDL1_CAEEL E3 ubiquitin-protein ligase hrd-like prote... 57 2e-007
>sp|Q9BV68|RN126_HUMAN RING finger protein 126 OS=Homo sapiens GN=RNF126 PE=1
SV=1
Length = 326
Score = 82 bits (201), Expect = 4e-015
Identities = 42/105 (40%), Positives = 57/105 (54%), Gaps = 5/105 (4%)
Frame = -2
Query: 512 GTPPARRDAVETLANVIV----LVPGMQCLVCLDDLEMGTVGKQMPCEHFFHSYCLLYWL 345
G PPA ++ ++ L V V + G++C VC DD +G +Q+PC H FH C++ WL
Sbjct: 201 GPPPADKEKIQALPTVPVTEEHVGSGLECPVCKDDYALGERVRQLPCNHLFHDGCIVPWL 260
Query: 344 QLHSSCPVCRSQLPTAEDETNGGG-DGSSTTSSSQGSENSDQEEE 213
+ H SCPVCR L TN G G S +SSS S +S E
Sbjct: 261 EQHDSCPVCRKSLTGQNTATNPPGLTGVSFSSSSSSSSSSSPSNE 305
>sp|Q0II22|RN126_BOVIN RING finger protein 126 OS=Bos taurus GN=RNF126 PE=2
SV=1
Length = 313
Score = 80 bits (197), Expect = 1e-014
Identities = 41/105 (39%), Positives = 58/105 (55%), Gaps = 11/105 (10%)
Frame = -2
Query: 512 GTPPARRDAVETLANVIV----LVPGMQCLVCLDDLEMGTVGKQMPCEHFFHSYCLLYWL 345
G PPA ++ ++ L V V + G++C VC DD +G +Q+PC H FH C++ WL
Sbjct: 204 GPPPADKEKIQALPTVPVTEEHVGSGLECPVCKDDYGLGEHVRQLPCNHLFHDGCIVPWL 263
Query: 344 QLHSSCPVCRSQLPTAEDETNGGG-------DGSSTTSSSQGSEN 231
+ H SCPVCR L T+ G SS++SSS G+EN
Sbjct: 264 EQHDSCPVCRKSLTGQNTATDPPGLAGVSFSSSSSSSSSSPGNEN 308
>sp|Q91YL2|RN126_MOUSE RING finger protein 126 OS=Mus musculus GN=Rnf126 PE=1
SV=1
Length = 313
Score = 80 bits (197), Expect = 1e-014
Identities = 40/105 (38%), Positives = 59/105 (56%), Gaps = 9/105 (8%)
Frame = -2
Query: 512 GTPPARRDAVETLANVIV----LVPGMQCLVCLDDLEMGTVGKQMPCEHFFHSYCLLYWL 345
G PPA ++ ++ L V V + G++C VC +D +G +Q+PC H FH C++ WL
Sbjct: 203 GPPPADKEKIQALPTVPVTEEHVGSGLECPVCKEDYALGESVRQLPCNHLFHDSCIVPWL 262
Query: 344 QLHSSCPVCRSQLPTAEDETN-----GGGDGSSTTSSSQGSENSD 225
+ H SCPVCR L TN G G SS++SSS S +++
Sbjct: 263 EQHDSCPVCRKSLTGQNTATNPPGLTGVGFSSSSSSSSSSSPSNE 307
>sp|Q7T0Q3|R126A_XENLA RING finger protein 126-A OS=Xenopus laevis GN=rnf126-a
PE=2 SV=1
Length = 312
Score = 80 bits (196), Expect = 2e-014
Identities = 37/107 (34%), Positives = 57/107 (53%), Gaps = 4/107 (3%)
Frame = -2
Query: 512 GTPPARRDAVETLANVIV----LVPGMQCLVCLDDLEMGTVGKQMPCEHFFHSYCLLYWL 345
G PPA + ++ L + + + G++C VC +D +G +Q+PC H FH+ C++ WL
Sbjct: 200 GPPPADNEKIQALPTIQITEEHVGSGLECPVCKEDYTVGECVRQLPCNHLFHNDCIIPWL 259
Query: 344 QLHSSCPVCRSQLPTAEDETNGGGDGSSTTSSSQGSENSDQEEEEED 204
+ H +CPVCR L TN G T SSS S +S +E+
Sbjct: 260 EQHDTCPVCRKSLSGQNTATNPPGLSEMTFSSSSTSSSSSTSPTDEN 306
>sp|Q6IRP0|R126B_XENLA RING finger protein 126-B OS=Xenopus laevis GN=rnf126-b
PE=2 SV=1
Length = 312
Score = 80 bits (195), Expect = 2e-014
Identities = 38/107 (35%), Positives = 56/107 (52%), Gaps = 4/107 (3%)
Frame = -2
Query: 512 GTPPARRDAVETLANVIVLVP----GMQCLVCLDDLEMGTVGKQMPCEHFFHSYCLLYWL 345
G PPA D ++ L + + G++C VC +D +G +Q+PC H FH+ C++ WL
Sbjct: 200 GPPPADTDKIQALPTIQITEEHVGFGLECPVCKEDYTVGESVRQLPCNHLFHNDCIIPWL 259
Query: 344 QLHSSCPVCRSQLPTAEDETNGGGDGSSTTSSSQGSENSDQEEEEED 204
+ H +CPVCR L TN G T SSS S +S +E+
Sbjct: 260 EQHDTCPVCRKSLSGQNTATNPPGLTDMTFSSSSTSSSSSTSPTDEN 306
>sp|Q6DIP3|RN126_XENTR RING finger protein 126 OS=Xenopus tropicalis GN=rnf126
PE=2 SV=1
Length = 311
Score = 79 bits (192), Expect = 5e-014
Identities = 37/107 (34%), Positives = 57/107 (53%), Gaps = 4/107 (3%)
Frame = -2
Query: 512 GTPPARRDAVETLANVIV----LVPGMQCLVCLDDLEMGTVGKQMPCEHFFHSYCLLYWL 345
G PPA + ++ L + + + G++C VC +D +G +Q+PC H FH+ C++ WL
Sbjct: 199 GPPPADTEKIQALPTIQITEEHVGSGLECPVCKEDYTVGESVRQLPCNHLFHNDCIIPWL 258
Query: 344 QLHSSCPVCRSQLPTAEDETNGGGDGSSTTSSSQGSENSDQEEEEED 204
+ H +CPVCR L TN G T SSS S +S +E+
Sbjct: 259 EQHDTCPVCRKSLSGQNTATNPPGLTEMTFSSSSTSSSSSTSPTDEN 305
>sp|Q9Y4L5|RN115_HUMAN E3 ubiquitin-protein ligase RNF115 OS=Homo sapiens
GN=RNF115 PE=1 SV=2
Length = 304
Score = 76 bits (186), Expect = 2e-013
Identities = 38/102 (37%), Positives = 58/102 (56%), Gaps = 8/102 (7%)
Frame = -2
Query: 512 GTPPARRDAVETLANVIV----LVPGMQCLVCLDDLEMGTVGKQMPCEHFFHSYCLLYWL 345
G PPA ++ + +L V V + G++C VC +D + +Q+PC HFFHS C++ WL
Sbjct: 200 GPPPADKEKITSLPTVTVTQEQVDMGLECPVCKEDYTVEEEVRQLPCNHFFHSSCIVPWL 259
Query: 344 QLHSSCPVCRSQLPTAEDETNGGGDGSSTTSSSQGSENSDQE 219
+LH +CPVCR L ED T ST +S+ ++D +
Sbjct: 260 ELHDTCPVCRKSL-NGEDSTR---QSQSTEASASNRFSNDSQ 297
>sp|Q9D0C1|RN115_MOUSE E3 ubiquitin-protein ligase RNF115 OS=Mus musculus
GN=Rnf115 PE=1 SV=1
Length = 305
Score = 76 bits (186), Expect = 2e-013
Identities = 40/101 (39%), Positives = 56/101 (55%), Gaps = 7/101 (6%)
Frame = -2
Query: 512 GTPPARRDAVETLANVIV----LVPGMQCLVCLDDLEMGTVGKQMPCEHFFHSYCLLYWL 345
G PPA ++ + +L V V + G++C VC +D + +Q+PC HFFHS C++ WL
Sbjct: 201 GPPPADKEKITSLPTVTVTQEQVNTGLECPVCKEDYTVEEKVRQLPCNHFFHSSCIVPWL 260
Query: 344 QLHSSCPVCRSQLPTAEDETNGGGDGSSTTSSSQGSENSDQ 222
+LH +CPVCR L ED T SS S+S N Q
Sbjct: 261 ELHDTCPVCRKSL-NGEDSTR--QTQSSEASASNRFSNDSQ 298
>sp|Q5M974|RN181_XENTR E3 ubiquitin-protein ligase RNF181 OS=Xenopus tropicalis
GN=rnf181 PE=2 SV=1
Length = 156
Score = 76 bits (186), Expect = 2e-013
Identities = 40/89 (44%), Positives = 51/89 (57%), Gaps = 6/89 (6%)
Frame = -2
Query: 542 DLTETDPRRYGTPPARRDAVETLANVIVLV----PGMQCLVCLDDLEMGTVGKQMPCEHF 375
D TE D R PPA + VE+L V V ++C VCL + E G +Q+PCEH
Sbjct: 43 DFTEWDQRL--PPPAAKKVVESLPKVTVTPEQADAALKCPVCLLEFEEGETVRQLPCEHL 100
Query: 374 FHSYCLLYWLQLHSSCPVCRSQLPTAEDE 288
FHS C+L WL +SCP+CR +LPT E
Sbjct: 101 FHSSCILPWLGKTNSCPLCRHELPTDSPE 129
>sp|Q6GPV5|RN181_XENLA E3 ubiquitin-protein ligase RNF181 OS=Xenopus laevis
GN=rnf181 PE=2 SV=1
Length = 156
Score = 76 bits (185), Expect = 3e-013
Identities = 40/94 (42%), Positives = 53/94 (56%), Gaps = 6/94 (6%)
Frame = -2
Query: 569 GPEFEAMLEDLTETDPRRYGTPPARRDAVETLANVIVLV----PGMQCLVCLDDLEMGTV 402
G + + D TE D R PPA + VE+L V V ++C VCL + E G
Sbjct: 34 GMDIDLGAVDFTEWDQRL--PPPASKKVVESLPKVTVTPEQADAALKCPVCLLEFEEGET 91
Query: 401 GKQMPCEHFFHSYCLLYWLQLHSSCPVCRSQLPT 300
+Q+PCEH FHS C+L WL +SCP+CR +LPT
Sbjct: 92 VRQLPCEHLFHSACILPWLGKTNSCPLCRHELPT 125
>sp|Q9SPL2|CIP8_ARATH E3 ubiquitin-protein ligase CIP8 OS=Arabidopsis thaliana
GN=CIP8 PE=1 SV=1
Length = 334
Score = 73 bits (177), Expect = 3e-012
Identities = 41/103 (39%), Positives = 54/103 (52%), Gaps = 6/103 (5%)
Frame = -2
Query: 518 RYGTPPARRDAVETLANVIVLVPG----MQCLVCLDDLEMGTVGKQMPCEHFFHSYCLLY 351
R G PPA + A+E L V M C VC D + MG GK++PC H +H C++
Sbjct: 227 RRGAPPAAKSAIEALETFEVSSSEGEMVMVCAVCKDGMVMGETGKKLPCGHCYHGDCIVP 286
Query: 350 WLQLHSSCPVCRSQLPT--AEDETNGGGDGSSTTSSSQGSENS 228
WL +SCPVCR QL T AE E S+ + S+ S +S
Sbjct: 287 WLGTRNSCPVCRFQLETDDAEYEEERKKRTSTVSDSAAASSSS 329
>sp|Q80U04|PJA2_MOUSE E3 ubiquitin-protein ligase Praja-2 OS=Mus musculus
GN=Pja2 PE=1 SV=2
Length = 707
Score = 64 bits (155), Expect = 9e-010
Identities = 28/101 (27%), Positives = 50/101 (49%), Gaps = 6/101 (5%)
Frame = -2
Query: 506 PPARRDAVETLANVIVL----VPGMQ--CLVCLDDLEMGTVGKQMPCEHFFHSYCLLYWL 345
PPA +++++ L +VL G + C +C + + ++PC HFFH C+ WL
Sbjct: 605 PPASKESIDGLPETLVLEDHTAIGQEQCCPICCSEYIKDDIATELPCHHFFHKPCVSIWL 664
Query: 344 QLHSSCPVCRSQLPTAEDETNGGGDGSSTTSSSQGSENSDQ 222
Q +CPVCR P A + + +S ++N+++
Sbjct: 665 QKSGTCPVCRRHFPPAVIDASAAASSDPDPDASPANDNAEE 705
>sp|Q63364|PJA2_RAT E3 ubiquitin-protein ligase Praja-2 OS=Rattus norvegicus
GN=Pja2 PE=2 SV=1
Length = 707
Score = 64 bits (155), Expect = 9e-010
Identities = 28/101 (27%), Positives = 50/101 (49%), Gaps = 6/101 (5%)
Frame = -2
Query: 506 PPARRDAVETLANVIVL----VPGMQ--CLVCLDDLEMGTVGKQMPCEHFFHSYCLLYWL 345
PPA +++++ L +VL G + C +C + + ++PC HFFH C+ WL
Sbjct: 605 PPASKESIDGLPETLVLEDHTAIGQEQCCPICCSEYIKDDIATELPCHHFFHKPCVSIWL 664
Query: 344 QLHSSCPVCRSQLPTAEDETNGGGDGSSTTSSSQGSENSDQ 222
Q +CPVCR P A + + +S ++N+++
Sbjct: 665 QKSGTCPVCRRHFPPAVIDASAAASSEPDLDASPANDNAEE 705
>sp|Q8NG27|PJA1_HUMAN E3 ubiquitin-protein ligase Praja-1 OS=Homo sapiens
GN=PJA1 PE=1 SV=2
Length = 643
Score = 62 bits (149), Expect = 5e-009
Identities = 25/74 (33%), Positives = 40/74 (54%), Gaps = 6/74 (8%)
Frame = -2
Query: 506 PPARRDAVETLANVIV------LVPGMQCLVCLDDLEMGTVGKQMPCEHFFHSYCLLYWL 345
PPA +++++ L ++V + M C +C + G V ++PC H+FH C+ WL
Sbjct: 567 PPASKESIDALPEILVTEDHGAVGQEMCCPICCSEYVKGEVATELPCHHYFHKPCVSIWL 626
Query: 344 QLHSSCPVCRSQLP 303
Q +CPVCR P
Sbjct: 627 QKSGTCPVCRCMFP 640
>sp|O55176|PJA1_MOUSE E3 ubiquitin-protein ligase Praja-1 OS=Mus musculus
GN=Pja1 PE=1 SV=3
Length = 578
Score = 62 bits (149), Expect = 5e-009
Identities = 25/74 (33%), Positives = 40/74 (54%), Gaps = 6/74 (8%)
Frame = -2
Query: 506 PPARRDAVETLANVIV------LVPGMQCLVCLDDLEMGTVGKQMPCEHFFHSYCLLYWL 345
PPA +++++ L ++V + M C +C + G V ++PC H+FH C+ WL
Sbjct: 502 PPASKESIDALPEILVTEDHGAVGQEMCCPICCSEYVKGEVATELPCHHYFHKPCVSIWL 561
Query: 344 QLHSSCPVCRSQLP 303
Q +CPVCR P
Sbjct: 562 QKSGTCPVCRCMFP 575
>sp|O43164|PJA2_HUMAN E3 ubiquitin-protein ligase Praja-2 OS=Homo sapiens
GN=PJA2 PE=1 SV=4
Length = 708
Score = 60 bits (143), Expect = 2e-008
Identities = 27/81 (33%), Positives = 42/81 (51%), Gaps = 6/81 (7%)
Frame = -2
Query: 506 PPARRDAVETLANVIVL----VPGMQ--CLVCLDDLEMGTVGKQMPCEHFFHSYCLLYWL 345
PPA +++++ L +VL G + C +C + + ++PC HFFH C+ WL
Sbjct: 606 PPASKESIDGLPETLVLEDHTAIGQEQCCPICCSEYIKDDIATELPCHHFFHKPCVSIWL 665
Query: 344 QLHSSCPVCRSQLPTAEDETN 282
Q +CPVCR P A E +
Sbjct: 666 QKSGTCPVCRRHFPPAVIEAS 686
>sp|Q5R4R1|PJA2_PONAB E3 ubiquitin-protein ligase Praja-2 OS=Pongo abelii
GN=PJA2 PE=2 SV=1
Length = 708
Score = 60 bits (143), Expect = 2e-008
Identities = 27/81 (33%), Positives = 42/81 (51%), Gaps = 6/81 (7%)
Frame = -2
Query: 506 PPARRDAVETLANVIVL----VPGMQ--CLVCLDDLEMGTVGKQMPCEHFFHSYCLLYWL 345
PPA +++++ L +VL G + C +C + + ++PC HFFH C+ WL
Sbjct: 606 PPASKESIDGLPETLVLEDHTAIGQEQCCPICCSEYIKDDIATELPCHHFFHKPCVSIWL 665
Query: 344 QLHSSCPVCRSQLPTAEDETN 282
Q +CPVCR P A E +
Sbjct: 666 QKSGTCPVCRRHFPPAVIEAS 686
>sp|Q0IJ20|RN145_XENTR RING finger protein 145 OS=Xenopus tropicalis GN=rnf145
PE=2 SV=1
Length = 695
Score = 59 bits (142), Expect = 3e-008
Identities = 34/120 (28%), Positives = 52/120 (43%), Gaps = 14/120 (11%)
Frame = -2
Query: 497 RRDAVETLANVIVLVPGMQ------CLVCLDDLEMGTVGKQMPCEHFFHSYCLLYWLQLH 336
RRDAV + ++ V C +C D+ + PC HFFH CL WL +
Sbjct: 512 RRDAVNKIKSLPVATKEQLEQHNDICSICYQDMNSAVI---TPCSHFFHPGCLKKWLYVQ 568
Query: 335 SSCPVCRSQLPTAEDETNGGGDGSSTTSSSQGSENS-----DQEEEEEDPMTA*PSPTLL 171
+CP+C QL + + G S+ S Q + N + E +P+ A P+ + L
Sbjct: 569 ETCPLCHCQLKSLSQQATGESGSSTNPVSEQSATNPPLGPVSRAEVTTEPLAAVPTRSAL 628
>sp|A8WWR3|HRDL1_CAEBR E3 ubiquitin-protein ligase hrd-like protein 1
OS=Caenorhabditis briggsae GN=hrdl-1 PE=3 SV=1
Length = 578
Score = 59 bits (141), Expect = 4e-008
Identities = 25/63 (39%), Positives = 40/63 (63%), Gaps = 3/63 (4%)
Frame = -2
Query: 443 QCLVCLDDLEMGTVGKQMPCEHFFHSYCLLYWLQLHSSCPVCRSQLPTAEDETNGGGDGS 264
+C+VC + L GT +++PC H FH +CL++WL SSCP CR +P+ ++E + G+
Sbjct: 349 RCIVCWELL--GT-SRRLPCSHQFHDWCLMWWLAQDSSCPTCRYVIPSPQEEASRTDSGN 405
Query: 263 STT 255
T
Sbjct: 406 GNT 408
>sp|P90859|HRDL1_CAEEL E3 ubiquitin-protein ligase hrd-like protein 1
OS=Caenorhabditis elegans GN=hrdl-1 PE=1 SV=2
Length = 564
Score = 57 bits (135), Expect = 2e-007
Identities = 23/52 (44%), Positives = 36/52 (69%), Gaps = 3/52 (5%)
Frame = -2
Query: 443 QCLVCLDDLEMGTVGKQMPCEHFFHSYCLLYWLQLHSSCPVCRSQLPTAEDE 288
+C+VC + L GT +++PC H FH +CL++WL SSCP CR +P+ +D+
Sbjct: 334 RCVVCWELL--GT-SRRLPCSHQFHDWCLMWWLAQDSSCPTCRCTIPSPQDQ 382
Database: UniProt/SwissProt
Posted date: Sat Aug 07 14:36:18 2010
Number of letters in database: 182,829,261
Number of sequences in database: 518,415
Lambda K H
0.267 0.041 0.140
Gapped
Lambda K H
0.267 0.041 0.140
Matrix: blosum62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 167,919,208,508
Number of Sequences: 518415
Number of Extensions: 167919208508
Number of Successful Extensions: 1034094832
Number of sequences better than 0.0: 0
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