BLASTX 7.6.2
Query= UN46587 /QuerySize=695
(694 letters)
Database: UniProt/SwissProt;
518,415 sequences; 182,829,261 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|O23240|D2HDH_ARATH D-2-hydroxyglutarate dehydrogenase, mitoch... 244 4e-064
sp|B8B7X6|D2HDH_ORYSI Probable D-2-hydroxyglutarate dehydrogenas... 178 5e-044
sp|Q7XI14|D2HDH_ORYSJ Probable D-2-hydroxyglutarate dehydrogenas... 178 5e-044
sp|P46681|DLD2_YEAST D-lactate dehydrogenase [cytochrome] 2, mit... 138 3e-032
sp|P39976|DLD3_YEAST D-lactate dehydrogenase [cytochrome] 3 OS=S... 138 5e-032
sp|P84850|D2HDH_RAT D-2-hydroxyglutarate dehydrogenase, mitochon... 134 5e-031
sp|Q8CIM3|D2HDH_MOUSE D-2-hydroxyglutarate dehydrogenase, mitoch... 134 7e-031
sp|A1L258|D2HDH_DANRE D-2-hydroxyglutarate dehydrogenase, mitoch... 132 2e-030
sp|Q1JPD3|D2HDH_BOVIN D-2-hydroxyglutarate dehydrogenase, mitoch... 131 7e-030
sp|Q8N465|D2HDH_HUMAN D-2-hydroxyglutarate dehydrogenase, mitoch... 127 6e-029
sp|Q9C1X2|YN53_SCHPO Putative D-lactate dehydrogenase C713.03, m... 127 1e-028
sp|P32891|DLD1_YEAST D-lactate dehydrogenase [cytochrome] 1, mit... 52 4e-006
>sp|O23240|D2HDH_ARATH D-2-hydroxyglutarate dehydrogenase, mitochondrial
OS=Arabidopsis thaliana GN=D2HGDH PE=1 SV=3
Length = 559
Score = 244 bits (622), Expect = 4e-064
Identities = 124/163 (76%), Positives = 141/163 (86%), Gaps = 4/163 (2%)
Frame = +3
Query: 171 KGRNTELLDHHH--HHHHPCLGGRNLWTMRPYKSFGSSSSSASKVQRNPLFSSLEPRDVS 344
KG+ EL D ++ HHPC+ ++ YK FG SS+AS +QRNPLFSSL+ +DVS
Sbjct: 44 KGKLFELSDGNYKTELHHPCISRNVGMLLQQYKCFG--SSAASLIQRNPLFSSLDSKDVS 101
Query: 345 YFKEILGEKHVVEDEERLETANTDWMHKYRGSSKLMLLPKNTEEVSQILKYCDSRSLAVV 524
YFKEILGEK+VVED+ERLETANTDWMHKY+GSSKLMLLPKNT+EVSQIL+YCDSR LAVV
Sbjct: 102 YFKEILGEKNVVEDKERLETANTDWMHKYKGSSKLMLLPKNTQEVSQILEYCDSRRLAVV 161
Query: 525 PQGGNTGLVGGSVPVFDEVIINVGLMNKVLSFDEVSGVLVCEA 653
PQGGNTGLVGGSVPVFDEVI+NVGLMNK+LSFDEVSGVLVCEA
Sbjct: 162 PQGGNTGLVGGSVPVFDEVIVNVGLMNKILSFDEVSGVLVCEA 204
Score = 64 bits (154), Expect = 8e-010
Identities = 36/64 (56%), Positives = 45/64 (70%), Gaps = 3/64 (4%)
Frame = +3
Query: 12 VMIHRWRRSGDFIRSACKSLSSFRQKHNSMSPSVSGFVNRYESKGKTFESNAGKGRNTEL 191
+M+ + RRSG+FIR CKSL S R +S+S SVSGFVN Y+SKGK FE + G + TEL
Sbjct: 1 MMMQKLRRSGEFIRFGCKSLISSRPNKDSVSRSVSGFVNHYKSKGKLFELSDGNYK-TEL 59
Query: 192 LDHH 203
HH
Sbjct: 60 --HH 61
>sp|B8B7X6|D2HDH_ORYSI Probable D-2-hydroxyglutarate dehydrogenase,
mitochondrial OS=Oryza sativa subsp. indica GN=D2HGDH PE=3 SV=1
Length = 559
Score = 178 bits (449), Expect = 5e-044
Identities = 85/127 (66%), Positives = 107/127 (84%)
Frame = +3
Query: 273 SSSSSASKVQRNPLFSSLEPRDVSYFKEILGEKHVVEDEERLETANTDWMHKYRGSSKLM 452
S SS+A+ VQRNP +S L DVSYFK ILG+ VV+DE+R+ AN DWM KY+GSS+L+
Sbjct: 79 SFSSAAAHVQRNPAYSVLNSDDVSYFKSILGDSGVVQDEDRVSVANMDWMGKYKGSSQLL 138
Query: 453 LLPKNTEEVSQILKYCDSRSLAVVPQGGNTGLVGGSVPVFDEVIINVGLMNKVLSFDEVS 632
LLPK+T EVS+IL YC+SR LAVVPQGGNTGLVGGSVPV+DEVII++G M+K+++FD V+
Sbjct: 139 LLPKSTAEVSKILSYCNSRRLAVVPQGGNTGLVGGSVPVYDEVIISLGGMDKIITFDNVN 198
Query: 633 GVLVCEA 653
G+L CEA
Sbjct: 199 GILTCEA 205
>sp|Q7XI14|D2HDH_ORYSJ Probable D-2-hydroxyglutarate dehydrogenase,
mitochondrial OS=Oryza sativa subsp. japonica GN=D2HGDH PE=3 SV=1
Length = 559
Score = 178 bits (449), Expect = 5e-044
Identities = 85/127 (66%), Positives = 107/127 (84%)
Frame = +3
Query: 273 SSSSSASKVQRNPLFSSLEPRDVSYFKEILGEKHVVEDEERLETANTDWMHKYRGSSKLM 452
S SS+A+ VQRNP +S L DVSYFK ILG+ VV+DE+R+ AN DWM KY+GSS+L+
Sbjct: 79 SFSSAAAHVQRNPAYSVLNSDDVSYFKSILGDSGVVQDEDRVSVANMDWMGKYKGSSQLL 138
Query: 453 LLPKNTEEVSQILKYCDSRSLAVVPQGGNTGLVGGSVPVFDEVIINVGLMNKVLSFDEVS 632
LLPK+T EVS+IL YC+SR LAVVPQGGNTGLVGGSVPV+DEVII++G M+K+++FD V+
Sbjct: 139 LLPKSTAEVSKILSYCNSRRLAVVPQGGNTGLVGGSVPVYDEVIISLGGMDKIITFDNVN 198
Query: 633 GVLVCEA 653
G+L CEA
Sbjct: 199 GILTCEA 205
>sp|P46681|DLD2_YEAST D-lactate dehydrogenase [cytochrome] 2, mitochondrial
OS=Saccharomyces cerevisiae GN=DLD2 PE=1 SV=1
Length = 530
Score = 138 bits (347), Expect = 3e-032
Identities = 66/128 (51%), Positives = 90/128 (70%), Gaps = 2/128 (1%)
Frame = +3
Query: 276 SSSSASKVQRNPLFSSLEPRDVSYFKEILGEKHVV--EDEERLETANTDWMHKYRGSSKL 449
+S + V R+P F L D++YFK IL E+ ++ + E L N DWM KY+G SKL
Sbjct: 45 TSENYPDVHRDPRFKKLTSDDLNYFKSILSEQEILRASESEDLSFYNEDWMRKYKGQSKL 104
Query: 450 MLLPKNTEEVSQILKYCDSRSLAVVPQGGNTGLVGGSVPVFDEVIINVGLMNKVLSFDEV 629
+L PK+ E+VS IL YC+ +AVVPQGGNTGLVGGSVP+FDE+I+++ +NK+ FD V
Sbjct: 105 VLRPKSVEKVSLILNYCNDEKIAVVPQGGNTGLVGGSVPIFDELILSLANLNKIRDFDPV 164
Query: 630 SGVLVCEA 653
SG+L C+A
Sbjct: 165 SGILKCDA 172
>sp|P39976|DLD3_YEAST D-lactate dehydrogenase [cytochrome] 3 OS=Saccharomyces
cerevisiae GN=DLD3 PE=1 SV=1
Length = 496
Score = 138 bits (346), Expect = 5e-032
Identities = 65/122 (53%), Positives = 88/122 (72%), Gaps = 2/122 (1%)
Frame = +3
Query: 294 KVQRNPLFSSLEPRDVSYFKEILGEKHVVEDE--ERLETANTDWMHKYRGSSKLMLLPKN 467
KV+RNP F L+ D++YF+ IL ++ + E L + N DWM KYRG S L+LLP +
Sbjct: 17 KVKRNPNFKVLDSEDLAYFRSILSNDEILNSQAPEELASFNQDWMKKYRGQSNLILLPNS 76
Query: 468 TEEVSQILKYCDSRSLAVVPQGGNTGLVGGSVPVFDEVIINVGLMNKVLSFDEVSGVLVC 647
T++VS+I+KYC+ + LAVVPQGGNT LVG SVPVFDE+++++ MNKV FD VSG C
Sbjct: 77 TDKVSKIMKYCNDKKLAVVPQGGNTDLVGASVPVFDEIVLSLRNMNKVRDFDPVSGTFKC 136
Query: 648 EA 653
+A
Sbjct: 137 DA 138
>sp|P84850|D2HDH_RAT D-2-hydroxyglutarate dehydrogenase, mitochondrial OS=Rattus
norvegicus GN=D2hgdh PE=3 SV=1
Length = 535
Score = 134 bits (337), Expect = 5e-031
Identities = 67/119 (56%), Positives = 93/119 (78%), Gaps = 2/119 (1%)
Frame = +3
Query: 297 VQRNPLFSSLEPRDVSYFKEILGEKHVVEDEERLETANTDWMHKYRGSSKLMLLPKNTEE 476
VQR P FS++ D++ F+ I+ + V+ D E+L+T N DW+ RG SK++L P+ +EE
Sbjct: 68 VQRLP-FSTVSEEDLAAFECIIPGR-VITDPEQLQTCNVDWLRTVRGCSKVLLRPQTSEE 125
Query: 477 VSQILKYCDSRSLAVVPQGGNTGLVGGSVPVFDEVIINVGLMNKVLSFDEVSGVLVCEA 653
VSQIL++C R+LAV PQGGNTG+VGGSVPVFDEVI++ LMN+V+SF +VSG+LVC+A
Sbjct: 126 VSQILRHCYKRNLAVNPQGGNTGMVGGSVPVFDEVILSTALMNQVISFHDVSGILVCQA 184
>sp|Q8CIM3|D2HDH_MOUSE D-2-hydroxyglutarate dehydrogenase, mitochondrial OS=Mus
musculus GN=D2hgdh PE=2 SV=2
Length = 535
Score = 134 bits (336), Expect = 7e-031
Identities = 67/119 (56%), Positives = 93/119 (78%), Gaps = 2/119 (1%)
Frame = +3
Query: 297 VQRNPLFSSLEPRDVSYFKEILGEKHVVEDEERLETANTDWMHKYRGSSKLMLLPKNTEE 476
VQR P FS++ D++ F+ I+ + V+ D E+L+T N DW+ RG SK++L P+ +EE
Sbjct: 68 VQRLP-FSTVSEEDLAAFECIIPGR-VITDPEQLQTCNVDWLKTVRGCSKVLLRPQTSEE 125
Query: 477 VSQILKYCDSRSLAVVPQGGNTGLVGGSVPVFDEVIINVGLMNKVLSFDEVSGVLVCEA 653
VSQIL++C R+LAV PQGGNTG+VGGSVPVFDEVI++ LMN+V+SF +VSG+LVC+A
Sbjct: 126 VSQILRHCYKRNLAVNPQGGNTGMVGGSVPVFDEVILSTALMNQVISFHDVSGILVCQA 184
>sp|A1L258|D2HDH_DANRE D-2-hydroxyglutarate dehydrogenase, mitochondrial
OS=Danio rerio GN=d2hgdh PE=2 SV=1
Length = 533
Score = 132 bits (331), Expect = 2e-030
Identities = 62/131 (47%), Positives = 93/131 (70%), Gaps = 1/131 (0%)
Frame = +3
Query: 261 KSFGSSSSSASKVQRNPLFSSLEPRDVSYFKEILGEKHVVEDEERLETANTDWMHKYRGS 440
+ G++ ++ S FS + D+S+F+ +L + + D + L+++N DW+ +GS
Sbjct: 52 RRLGANPANPSAAPPRLPFSRVTQEDLSFFRALLPGR-TITDPDLLKSSNVDWLKTVQGS 110
Query: 441 SKLMLLPKNTEEVSQILKYCDSRSLAVVPQGGNTGLVGGSVPVFDEVIINVGLMNKVLSF 620
S ++L PK TE VSQIL+YC+ R+LAV PQGGNTGLVGGSVPVFDE+I++ LMN+V +F
Sbjct: 111 SDVLLRPKTTEGVSQILRYCNERNLAVCPQGGNTGLVGGSVPVFDEIILSTSLMNQVFAF 170
Query: 621 DEVSGVLVCEA 653
D +SG+L C+A
Sbjct: 171 DNISGILTCQA 181
>sp|Q1JPD3|D2HDH_BOVIN D-2-hydroxyglutarate dehydrogenase, mitochondrial OS=Bos
taurus GN=D2HGDH PE=2 SV=2
Length = 544
Score = 131 bits (327), Expect = 7e-030
Identities = 65/119 (54%), Positives = 88/119 (73%), Gaps = 2/119 (1%)
Frame = +3
Query: 297 VQRNPLFSSLEPRDVSYFKEILGEKHVVEDEERLETANTDWMHKYRGSSKLMLLPKNTEE 476
VQR P FS + D++ + ++ + V+ D E LE N DW+ RGSSK++L P+ T+E
Sbjct: 77 VQRLP-FSVVSEDDLAALERVVPGR-VITDPEELEPPNVDWLRTVRGSSKVLLRPRTTQE 134
Query: 477 VSQILKYCDSRSLAVVPQGGNTGLVGGSVPVFDEVIINVGLMNKVLSFDEVSGVLVCEA 653
V+ IL+YC R+LAV PQGGNTG+VGGS PVFDE+I++ LMN+VLSF +VSGVLVC+A
Sbjct: 135 VAHILRYCHERNLAVNPQGGNTGMVGGSTPVFDEIILSTALMNQVLSFHDVSGVLVCQA 193
>sp|Q8N465|D2HDH_HUMAN D-2-hydroxyglutarate dehydrogenase, mitochondrial OS=Homo
sapiens GN=D2HGDH PE=1 SV=3
Length = 521
Score = 127 bits (319), Expect = 6e-029
Identities = 64/119 (53%), Positives = 88/119 (73%), Gaps = 2/119 (1%)
Frame = +3
Query: 297 VQRNPLFSSLEPRDVSYFKEILGEKHVVEDEERLETANTDWMHKYRGSSKLMLLPKNTEE 476
V+R P FS++ +D++ F+ I+ VV D E L+ N DW+ RG SK++L P+ +EE
Sbjct: 54 VRRLP-FSTVSKQDLAAFERIV-PGGVVTDPEALQAPNVDWLRTLRGCSKVLLRPRTSEE 111
Query: 477 VSQILKYCDSRSLAVVPQGGNTGLVGGSVPVFDEVIINVGLMNKVLSFDEVSGVLVCEA 653
VS IL++C R+LAV PQGGNTG+VGGSVPVFDE+I++ MN+VLSF VSG+LVC+A
Sbjct: 112 VSHILRHCHERNLAVNPQGGNTGMVGGSVPVFDEIILSTARMNRVLSFHSVSGILVCQA 170
>sp|Q9C1X2|YN53_SCHPO Putative D-lactate dehydrogenase C713.03, mitochondrial
OS=Schizosaccharomyces pombe GN=SPBC713.03 PE=2 SV=1
Length = 526
Score = 127 bits (317), Expect = 1e-028
Identities = 64/138 (46%), Positives = 93/138 (67%), Gaps = 5/138 (3%)
Frame = +3
Query: 243 WTMRPYKSFGSSSSSASKVQRN-PLFSSLEPRDVSYFKEILGEKHVVEDEERLETANTDW 419
+T YKS A +++ +F S+ +D S ++ D L+ N DW
Sbjct: 34 FTFESYKSLHRDPKYAKLSEQDVQVFKSIIGKDGS----LIDGLDKSTDPADLDAFNIDW 89
Query: 420 MHKYRGSSKLMLLPKNTEEVSQILKYCDSRSLAVVPQGGNTGLVGGSVPVFDEVIINVGL 599
M+KYRG ++L L PK T++VS+ILKYC+ + LAVVPQGGNTGLVGGSVPVFDE+++N+GL
Sbjct: 90 MNKYRGKTQLALKPKTTQQVSEILKYCNQKKLAVVPQGGNTGLVGGSVPVFDEIVLNLGL 149
Query: 600 MNKVLSFDEVSGVLVCEA 653
MN++ +FDE+SGV+ ++
Sbjct: 150 MNQIHTFDEISGVITLDS 167
>sp|P32891|DLD1_YEAST D-lactate dehydrogenase [cytochrome] 1, mitochondrial
OS=Saccharomyces cerevisiae GN=DLD1 PE=1 SV=2
Length = 587
Score = 52 bits (122), Expect = 4e-006
Identities = 34/119 (28%), Positives = 62/119 (52%), Gaps = 9/119 (7%)
Frame = +3
Query: 339 VSYFKEILGEK--HVVEDEERLETANTDWMHKYRGS----SKLMLLPKNTEEVSQILKYC 500
V K++LG K + + + L+ + + + + S +++L P TEEVS+ILK C
Sbjct: 111 VEDLKQVLGNKPENYSDAKSDLDAHSDTYFNTHHPSPEQRPRIILFPHTTEEVSKILKIC 170
Query: 501 DSRSLAVVPQGGNTGLVGGSVP--VFDEVIINVG-LMNKVLSFDEVSGVLVCEADAFWK 668
++ VVP G T L G +P + D + +++ MN V+ FD++ + +A W+
Sbjct: 171 HDNNMPVVPFSGGTSLEGHFLPTRIGDTITVDLSKFMNNVVKFDKLDLDITVQAGLPWE 229
Database: UniProt/SwissProt
Posted date: Sat Aug 07 14:36:18 2010
Number of letters in database: 182,829,261
Number of sequences in database: 518,415
Lambda K H
0.267 0.041 0.140
Gapped
Lambda K H
0.267 0.041 0.140
Matrix: blosum62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 174,418,403,310
Number of Sequences: 518415
Number of Extensions: 174418403310
Number of Successful Extensions: 1059328112
Number of sequences better than 0.0: 0
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