BLASTX 7.6.2
Query= UN48580 /QuerySize=765
(764 letters)
Database: UniProt/SwissProt;
518,415 sequences; 182,829,261 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q8CHR6|DPYD_MOUSE Dihydropyrimidine dehydrogenase [NADP+] OS=... 144 7e-034
sp|O89000|DPYD_RAT Dihydropyrimidine dehydrogenase [NADP+] OS=Ra... 144 7e-034
sp|Q18164|DPYD_CAEEL Dihydropyrimidine dehydrogenase [NADP+] OS=... 143 2e-033
sp|Q12882|DPYD_HUMAN Dihydropyrimidine dehydrogenase [NADP+] OS=... 143 2e-033
sp|Q28943|DPYD_PIG Dihydropyrimidine dehydrogenase [NADP+] OS=Su... 142 4e-033
sp|A8XKG6|DPYD_CAEBR Probable dihydropyrimidine dehydrogenase [N... 141 6e-033
sp|Q55FT1|DPYD_DICDI Dihydropyrimidine dehydrogenase [NADP+] OS=... 141 6e-033
sp|Q5R895|DPYD_PONAB Dihydropyrimidine dehydrogenase [NADP+] OS=... 141 6e-033
sp|Q6NYG8|DPYD_DANRE Dihydropyrimidine dehydrogenase [NADP+] OS=... 139 2e-032
sp|Q28007|DPYD_BOVIN Dihydropyrimidine dehydrogenase [NADP+] OS=... 136 2e-031
sp|P25889|YEIA_ECOLI Uncharacterized protein yeiA OS=Escherichia... 127 7e-029
>sp|Q8CHR6|DPYD_MOUSE Dihydropyrimidine dehydrogenase [NADP+] OS=Mus musculus
GN=Dpyd PE=2 SV=1
Length = 1025
Score = 144 bits (362), Expect = 7e-034
Identities = 78/176 (44%), Positives = 104/176 (59%), Gaps = 6/176 (3%)
Frame = +2
Query: 230 TPDSAPDLSVTVNGLKMPNPFVIGSGPPGTNYTVMKRAFDEGWGGVIAKTVSLDASKVIN 409
TP D+SV + GL+ PNPF + S P T+ +++RAF+ GWG + KT SLD V N
Sbjct: 526 TPVDLVDISVEMAGLRFPNPFGLASATPATSTPMIRRAFEAGWGFALTKTFSLDKDIVTN 585
Query: 410 VTPRYARLKTGS--NGSAKTDVIGWQNIELISDRPLETMLKEFKQLKQEYPDRILIASIM 583
V+PR R T G ++ + NIELIS++ +LK ++PD ILIASIM
Sbjct: 586 VSPRIIRGTTSGPLYGPGQSSFL---NIELISEKTAAYWCHSVTELKADFPDNILIASIM 642
Query: 584 EEYSKTGWEELIDRVEQTGVDALEINFSCPHGMPERRMGAAVGQTVRFLR-VCGWI 748
Y+K+ W EL E +G DALE+N SCPHGM ER MG A GQ +R +C W+
Sbjct: 643 CSYNKSDWMELSKMAEASGADALELNLSCPHGMGERGMGLACGQDPELVRNICRWV 698
>sp|O89000|DPYD_RAT Dihydropyrimidine dehydrogenase [NADP+] OS=Rattus norvegicus
GN=Dpyd PE=2 SV=1
Length = 1025
Score = 144 bits (362), Expect = 7e-034
Identities = 79/179 (44%), Positives = 104/179 (58%), Gaps = 6/179 (3%)
Frame = +2
Query: 230 TPDSAPDLSVTVNGLKMPNPFVIGSGPPGTNYTVMKRAFDEGWGGVIAKTVSLDASKVIN 409
TP D+SV + GL+ PNPF + S P T+ +++RAF+ GWG + KT SLD V N
Sbjct: 526 TPVDLVDISVEMAGLRFPNPFGLASATPATSTPMIRRAFEAGWGFALTKTFSLDKDIVTN 585
Query: 410 VTPRYARLKTGS--NGSAKTDVIGWQNIELISDRPLETMLKEFKQLKQEYPDRILIASIM 583
V+PR R T G ++ + NIELIS++ +LK ++PD ILIASIM
Sbjct: 586 VSPRIIRGTTSGPLYGPGQSSFL---NIELISEKTAAYWCHSVTELKADFPDNILIASIM 642
Query: 584 EEYSKTGWEELIDRVEQTGVDALEINFSCPHGMPERRMGAAVGQTVRFLR-VCGWIMLS 757
Y+K W EL E +G DALE+N SCPHGM ER MG A GQ +R +C W+ S
Sbjct: 643 CSYNKNDWMELSKMAEASGADALELNLSCPHGMGERGMGLACGQDPELVRNICRWVRQS 701
>sp|Q18164|DPYD_CAEEL Dihydropyrimidine dehydrogenase [NADP+] OS=Caenorhabditis
elegans GN=dpyd-1 PE=2 SV=2
Length = 1059
Score = 143 bits (359), Expect = 2e-033
Identities = 75/179 (41%), Positives = 109/179 (60%), Gaps = 12/179 (6%)
Frame = +2
Query: 230 TPDSAPDLSVTVNGLKMPNPFVIGSGPPGTNYTVMKRAFDEGWGGVIAKTVSLDASKVIN 409
TP D+SV + G+K NPF + S PP T+ + +RAF++GWG ++ KT LD V N
Sbjct: 540 TPIDEVDISVDMCGVKFENPFGLASAPPTTSGPMCRRAFEQGWGFILTKTYGLDKDLVTN 599
Query: 410 VTPRYARLKTGSNGSAKTDVIG-----WQNIELISDRPLETMLKEFKQLKQEYPDRILIA 574
V+PR R GS + G + NIELIS++ E L+ ++LK+++P +I+IA
Sbjct: 600 VSPRIVR------GSTSGPLYGPNQGSFMNIELISEKSCEYWLQCIRELKRDHPTKIVIA 653
Query: 575 SIMEEYSKTGWEELIDRVEQTGVDALEINFSCPHGMPERRMGAAVGQTVRFLR-VCGWI 748
SIM Y+K W EL + E+ G D LE+N SCPHGM E+ MG A GQ+ ++ +C W+
Sbjct: 654 SIMCVYNKADWIELATKSEEAGADILELNLSCPHGMGEKGMGLACGQSPEIVKEICRWV 712
>sp|Q12882|DPYD_HUMAN Dihydropyrimidine dehydrogenase [NADP+] OS=Homo sapiens
GN=DPYD PE=1 SV=2
Length = 1025
Score = 143 bits (359), Expect = 2e-033
Identities = 77/174 (44%), Positives = 103/174 (59%), Gaps = 2/174 (1%)
Frame = +2
Query: 230 TPDSAPDLSVTVNGLKMPNPFVIGSGPPGTNYTVMKRAFDEGWGGVIAKTVSLDASKVIN 409
TP D+SV + GLK NPF + S P T+ ++++RAF+ GWG + KT SLD V N
Sbjct: 526 TPIDLVDISVEMAGLKFINPFGLASATPATSTSMIRRAFEAGWGFALTKTFSLDKDIVTN 585
Query: 410 VTPRYARLKTGSNGSAKTDVIGWQNIELISDRPLETMLKEFKQLKQEYPDRILIASIMEE 589
V+PR R T S + NIELIS++ + +LK ++PD I+IASIM
Sbjct: 586 VSPRIIR-GTTSGPMYGPGQSSFLNIELISEKTAAYWCQSVTELKADFPDNIVIASIMCS 644
Query: 590 YSKTGWEELIDRVEQTGVDALEINFSCPHGMPERRMGAAVGQTVRFLR-VCGWI 748
Y+K W EL + E +G DALE+N SCPHGM ER MG A GQ +R +C W+
Sbjct: 645 YNKNDWTELAKKSEDSGADALELNLSCPHGMGERGMGLACGQDPELVRNICRWV 698
>sp|Q28943|DPYD_PIG Dihydropyrimidine dehydrogenase [NADP+] OS=Sus scrofa
GN=DPYD PE=1 SV=1
Length = 1025
Score = 142 bits (356), Expect = 4e-033
Identities = 77/174 (44%), Positives = 103/174 (59%), Gaps = 2/174 (1%)
Frame = +2
Query: 230 TPDSAPDLSVTVNGLKMPNPFVIGSGPPGTNYTVMKRAFDEGWGGVIAKTVSLDASKVIN 409
TP D+SV + GLK NPF + S P T+ ++++RAF+ GWG + KT SLD V N
Sbjct: 526 TPVDLVDISVEMAGLKFINPFGLASAAPTTSSSMIRRAFEAGWGFALTKTFSLDKDIVTN 585
Query: 410 VTPRYARLKTGSNGSAKTDVIGWQNIELISDRPLETMLKEFKQLKQEYPDRILIASIMEE 589
V+PR R T S + NIELIS++ + +LK ++PD I+IASIM
Sbjct: 586 VSPRIVR-GTTSGPMYGPGQSSFLNIELISEKTAAYWCQSVTELKADFPDNIVIASIMCS 644
Query: 590 YSKTGWEELIDRVEQTGVDALEINFSCPHGMPERRMGAAVGQTVRFLR-VCGWI 748
Y+K W EL + E +G DALE+N SCPHGM ER MG A GQ +R +C W+
Sbjct: 645 YNKNDWMELSRKAEASGADALELNLSCPHGMGERGMGLACGQDPELVRNICRWV 698
>sp|A8XKG6|DPYD_CAEBR Probable dihydropyrimidine dehydrogenase [NADP+]
OS=Caenorhabditis briggsae GN=dpyd-1 PE=3 SV=2
Length = 1053
Score = 141 bits (354), Expect = 6e-033
Identities = 74/179 (41%), Positives = 108/179 (60%), Gaps = 12/179 (6%)
Frame = +2
Query: 230 TPDSAPDLSVTVNGLKMPNPFVIGSGPPGTNYTVMKRAFDEGWGGVIAKTVSLDASKVIN 409
TP D+SV + G+K NPF + S PP T+ + +RAF++GWG ++ KT LD V N
Sbjct: 550 TPIDEVDISVDMCGVKFENPFGLASAPPTTSGPMCRRAFEQGWGFILTKTYGLDKDLVTN 609
Query: 410 VTPRYARLKTGSNGSAKTDVIG-----WQNIELISDRPLETMLKEFKQLKQEYPDRILIA 574
V+PR R GS + G + NIELIS++ E L+ ++LK+++P +I++A
Sbjct: 610 VSPRIVR------GSTSGPLYGPNQGSFMNIELISEKSCEYWLQCIRELKRDHPTKIVVA 663
Query: 575 SIMEEYSKTGWEELIDRVEQTGVDALEINFSCPHGMPERRMGAAVGQTVRFLR-VCGWI 748
SIM Y+K W EL + E G D LE+N SCPHGM E+ MG A GQ+ ++ +C W+
Sbjct: 664 SIMCVYNKEDWIELATKSEAAGADILELNLSCPHGMGEKGMGLACGQSPEIVKEICRWV 722
>sp|Q55FT1|DPYD_DICDI Dihydropyrimidine dehydrogenase [NADP+] OS=Dictyostelium
discoideum GN=pyd1 PE=2 SV=1
Length = 1009
Score = 141 bits (354), Expect = 6e-033
Identities = 72/174 (41%), Positives = 103/174 (59%), Gaps = 2/174 (1%)
Frame = +2
Query: 230 TPDSAPDLSVTVNGLKMPNPFVIGSGPPGTNYTVMKRAFDEGWGGVIAKTVSLDASKVIN 409
TP D+SV + G+K PNPF + S P T+ +++R+F++GWG + KT SLD V N
Sbjct: 524 TPIDLVDISVEMCGMKFPNPFGLASATPATSAAMIRRSFEQGWGFAVTKTFSLDKDLVTN 583
Query: 410 VTPRYARLKTGSNGSAKTDVIGWQNIELISDRPLETMLKEFKQLKQEYPDRILIASIMEE 589
V+PR R T + + NIELIS++ K +LK+++PDRI+IASIM
Sbjct: 584 VSPRIVRGTTSGHHFGPGQG-AFLNIELISEKTCHYWCKAIGELKRDFPDRIVIASIMCG 642
Query: 590 YSKTGWEELIDRVEQTGVDALEINFSCPHGMPERRMGAAVGQ-TVRFLRVCGWI 748
++K W +L E +G D +E+N SCPHGM E+ MG A GQ T +C W+
Sbjct: 643 FNKEDWTQLAKMAEASGADGIELNLSCPHGMGEKGMGLACGQDTELVFHICQWV 696
>sp|Q5R895|DPYD_PONAB Dihydropyrimidine dehydrogenase [NADP+] OS=Pongo abelii
GN=DPYD PE=2 SV=1
Length = 1025
Score = 141 bits (354), Expect = 6e-033
Identities = 75/168 (44%), Positives = 101/168 (60%), Gaps = 2/168 (1%)
Frame = +2
Query: 248 DLSVTVNGLKMPNPFVIGSGPPGTNYTVMKRAFDEGWGGVIAKTVSLDASKVINVTPRYA 427
D+SV + GLK NPF + S P T+ ++++RAF+ GWG + KT SLD V NV+PR
Sbjct: 532 DISVEMAGLKFINPFGLASATPATSTSMIRRAFEAGWGFALTKTFSLDKDIVTNVSPRIV 591
Query: 428 RLKTGSNGSAKTDVIGWQNIELISDRPLETMLKEFKQLKQEYPDRILIASIMEEYSKTGW 607
R T S + NIELIS++ + +LK ++PD I+IASIM Y+K W
Sbjct: 592 R-GTTSGPMYGPGQSSFLNIELISEKTAAYWCQSVTELKADFPDNIVIASIMCSYNKNDW 650
Query: 608 EELIDRVEQTGVDALEINFSCPHGMPERRMGAAVGQTVRFLR-VCGWI 748
EL + E +G DALE+N SCPHGM ER MG A GQ +R +C W+
Sbjct: 651 TELAKKSEDSGADALELNLSCPHGMGERGMGLACGQDPELVRNICRWV 698
>sp|Q6NYG8|DPYD_DANRE Dihydropyrimidine dehydrogenase [NADP+] OS=Danio rerio
GN=dpyd PE=2 SV=1
Length = 1022
Score = 139 bits (350), Expect = 2e-032
Identities = 72/173 (41%), Positives = 102/173 (58%), Gaps = 12/173 (6%)
Frame = +2
Query: 248 DLSVTVNGLKMPNPFVIGSGPPGTNYTVMKRAFDEGWGGVIAKTVSLDASKVINVTPRYA 427
D+SV + G+K PNPF + S PP T+ +++RAF++GWG + KT LD V NV+PR
Sbjct: 532 DISVEMCGIKFPNPFGLASAPPTTSAAMIRRAFEQGWGFALTKTFGLDKDLVTNVSPRIV 591
Query: 428 RLKTGSNGSAKTDVIG-----WQNIELISDRPLETMLKEFKQLKQEYPDRILIASIMEEY 592
R G+ + G + NIELIS++ K +LK ++P I+IASIM Y
Sbjct: 592 R------GTTSGHIFGPGQGSFLNIELISEKTAAYWCKSVAELKADFPKNIIIASIMCSY 645
Query: 593 SKTGWEELIDRVEQTGVDALEINFSCPHGMPERRMGAAVGQTVRFLR-VCGWI 748
++ W EL +++ DALE+N SCPHGM ER MG A GQ +R +C W+
Sbjct: 646 NQADWTELAKMAQESQADALELNLSCPHGMGERGMGLACGQDPELVRNICRWV 698
>sp|Q28007|DPYD_BOVIN Dihydropyrimidine dehydrogenase [NADP+] OS=Bos taurus
GN=DPYD PE=1 SV=1
Length = 1025
Score = 136 bits (342), Expect = 2e-031
Identities = 74/174 (42%), Positives = 101/174 (58%), Gaps = 2/174 (1%)
Frame = +2
Query: 230 TPDSAPDLSVTVNGLKMPNPFVIGSGPPGTNYTVMKRAFDEGWGGVIAKTVSLDASKVIN 409
TP D+SV + LK NPF + S P T+ ++++RAF+ GW + KT SLD V N
Sbjct: 526 TPIDLVDISVEMAALKFTNPFGLASATPTTSSSMIRRAFEAGWAFALTKTFSLDKDIVTN 585
Query: 410 VTPRYARLKTGSNGSAKTDVIGWQNIELISDRPLETMLKEFKQLKQEYPDRILIASIMEE 589
V+PR R T S + NIELIS++ + +LK ++PD I+IASIM
Sbjct: 586 VSPRIIR-GTTSGPMYGPGQSSFLNIELISEKTAAYWCQSVTELKADFPDNIVIASIMCS 644
Query: 590 YSKTGWEELIDRVEQTGVDALEINFSCPHGMPERRMGAAVGQTVRFLR-VCGWI 748
Y++ W EL + E +G DALE+N SCPHGM ER MG A GQ +R +C W+
Sbjct: 645 YNRNDWMELSRKAEASGADALELNLSCPHGMGERGMGLACGQDPELVRNICRWV 698
>sp|P25889|YEIA_ECOLI Uncharacterized protein yeiA OS=Escherichia coli (strain
K12) GN=yeiA PE=3 SV=3
Length = 411
Score = 127 bits (319), Expect = 7e-029
Identities = 68/157 (43%), Positives = 97/157 (61%), Gaps = 9/157 (5%)
Frame = +2
Query: 248 DLSVTVNGLKMPNPFVIGSGPPGTNYTVMKRAFDEGWGGVIAKTVSLDASKVINVTPRYA 427
DLS+T G+K PNPF + S P G Y + +A+D GWGGV+ KT+ + V+PR+
Sbjct: 5 DLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIAN--EVSPRFD 62
Query: 428 RLKTGSNGSAKTDVIGWQNIELISDRPLETMLKEFKQLKQEYPDRILIASIMEEYSKTGW 607
L G IG++N+E I++ PLE L ++LK++YPD++LIASIM E ++ W
Sbjct: 63 HLVKEDTG-----FIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGE-NEQQW 116
Query: 608 EELIDRVEQTGVDALEINFSCPHGMPERRMGAAVGQT 718
EEL V++ G D +E NFSCP M MG+ VGQ+
Sbjct: 117 EELARLVQEAGADMIECNFSCPQ-MTSHAMGSDVGQS 152
Database: UniProt/SwissProt
Posted date: Sat Aug 07 14:36:18 2010
Number of letters in database: 182,829,261
Number of sequences in database: 518,415
Lambda K H
0.267 0.041 0.140
Gapped
Lambda K H
0.267 0.041 0.140
Matrix: blosum62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 182,561,833,118
Number of Sequences: 518415
Number of Extensions: 182561833118
Number of Successful Extensions: 1116914633
Number of sequences better than 0.0: 0
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