BLASTX 7.6.2
Query= UN49404 /QuerySize=1131
(1130 letters)
Database: UniProt/SwissProt;
518,415 sequences; 182,829,261 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q2MHE4|HT1_ARATH Serine/threonine-protein kinase HT1 OS=Arabi... 278 8e-074
sp|Q55GU0|Y9955_DICDI Probable serine/threonine-protein kinase D... 203 2e-051
sp|Q55A09|Y9963_DICDI Probable serine/threonine-protein kinase D... 196 3e-049
sp|Q9NYL2|MLTK_HUMAN Mitogen-activated protein kinase kinase kin... 180 2e-044
sp|Q16584|M3K11_HUMAN Mitogen-activated protein kinase kinase ki... 178 1e-043
sp|Q80XI6|M3K11_MOUSE Mitogen-activated protein kinase kinase ki... 177 1e-043
sp|Q66HA1|M3K11_RAT Mitogen-activated protein kinase kinase kina... 177 1e-043
sp|Q9ESL4|MLTK_MOUSE Mitogen-activated protein kinase kinase kin... 174 1e-042
sp|Q95UN8|M3KSL_DROME Mitogen-activated protein kinase kinase ki... 174 2e-042
sp|Q54I36|PYK3_DICDI Dual specificity protein kinase pyk3 OS=Dic... 161 1e-038
sp|Q54L00|LIMKA_DICDI Probable LIM domain-containing serine/thre... 161 1e-038
sp|P0CD62|LIMKB_DICDI Probable LIM domain-containing serine/thre... 159 5e-038
sp|Q54TA1|DRKC_DICDI Probable serine/threonine-protein kinase dr... 156 3e-037
sp|Q5UQG7|YR818_MIMIV Putative serine/threonine-protein kinase/r... 155 6e-037
sp|Q7T6X2|YR826_MIMIV Putative serine/threonine-protein kinase/r... 155 6e-037
sp|Q54RZ7|Y1199_DICDI Probable serine/threonine-protein kinase D... 153 3e-036
sp|Q7T6Y2|YR831_MIMIV Putative serine/threonine-protein kinase/r... 151 1e-035
sp|P00522|ABL_DROME Tyrosine-protein kinase Abl OS=Drosophila me... 146 5e-034
sp|P18161|PYK2_DICDI Dual specificity protein kinase pyk2 OS=Dic... 129 3e-029
sp|Q8VDG6|M3KL4_MOUSE Mitogen-activated protein kinase kinase ki... 103 3e-021
>sp|Q2MHE4|HT1_ARATH Serine/threonine-protein kinase HT1 OS=Arabidopsis thaliana
GN=HT1 PE=1 SV=1
Length = 390
Score = 278 bits (709), Expect = 8e-074
Identities = 131/250 (52%), Positives = 175/250 (70%)
Frame = +2
Query: 5 FAQGAFGKLYRGTYKGEDVAIKLLERPENSPEKAQALEQQFQQEVSMLSFLKHPNIVRFI 184
FA GA ++YRG YK VA+K++ P + E LEQQF+ EV++LS L HPNIV+FI
Sbjct: 92 FASGAHSRIYRGIYKQRAVAVKMVRIPTHKEETRAKLEQQFKSEVALLSRLFHPNIVQFI 151
Query: 185 GACIKPMVLCIVTEYAKGGSVRQFLTKRQNRAVPLKLAVKQALDVARGMAYVHERNFIHR 364
AC KP V CI+TEY G++R +L K++ ++ ++ ++ ALD++RGM Y+H + IHR
Sbjct: 152 AACKKPPVYCIITEYMSQGNLRMYLNKKEPYSLSIETVLRLALDISRGMEYLHSQGVIHR 211
Query: 365 DLKSDNLLISADRSIKIADFGVARIEVQTEGMTPETGTYRWMAPEMIQHRPYTQKVDVYS 544
DLKS+NLL++ + +K+ADFG + +E Q GTYRWMAPEMI+ +PYT+KVDVYS
Sbjct: 212 DLKSNNLLLNDEMRVKVADFGTSCLETQCREAKGNMGTYRWMAPEMIKEKPYTRKVDVYS 271
Query: 545 FGIVLWELITGLLPFQNMTAVQAAFAVVNRGVRPTVPADCLPVLGEIMTRCWDADPEVRP 724
FGIVLWEL T LLPFQ MT VQAAFAV + RP +PA C P L ++ RCW +P RP
Sbjct: 272 FGIVLWELTTALLPFQGMTPVQAAFAVAEKNERPPLPASCQPALAHLIKRCWSENPSKRP 331
Query: 725 CFAEIVNLLE 754
F+ IV +LE
Sbjct: 332 DFSNIVAVLE 341
>sp|Q55GU0|Y9955_DICDI Probable serine/threonine-protein kinase DDB_G0267514
OS=Dictyostelium discoideum GN=DDB_G0267514 PE=3 SV=1
Length = 916
Score = 203 bits (516), Expect = 2e-051
Identities = 104/247 (42%), Positives = 158/247 (63%), Gaps = 4/247 (1%)
Frame = +2
Query: 11 QGAFGKLYRGTYKGEDVAIKLLERPENSPEKAQALEQQFQQEVSMLSFLKHPNIVRFIGA 190
+G FG +Y+G ++G VAIK ++ N Q LE +F++E+++LS L+HPNIV + A
Sbjct: 670 EGTFGVVYKGLWRGSSVAIKQIK--INEDVNNQVLE-EFRKELTILSRLRHPNIVLLMAA 726
Query: 191 CIKPMVLCIVTEYAKGGSVRQFLTKRQNRAVPLKLAVKQALDVARGMAYVHERNFIHRDL 370
C P LC +TEY GGS+ L ++ + + ++L K A+ +A+GM Y+H IHRD+
Sbjct: 727 CTAPPNLCFITEYLPGGSLYDALHSKKIK-MNMQLYKKLAIQIAQGMNYLHLSGVIHRDI 785
Query: 371 KSDNLLISADRSIKIADFGVARIEVQTEGMTPETGTYRWMAPEMIQHRPYTQKVDVYSFG 550
KS NLL+ ++KI DFG+++++ ++ MT G+ WM+PE++ YT+KVDVY+FG
Sbjct: 786 KSLNLLLDEHMNVKICDFGLSKLKSKSTEMTKSIGSPIWMSPELLMGEDYTEKVDVYAFG 845
Query: 551 IVLWELITGLLPFQNMTAVQAAFAVVNRGVRPTVPADCLPVLGEIMTRCWDADPEVRPCF 730
I+LWEL TG LP+ + +VQ A AV + +RP +P L ++ CW DP RP F
Sbjct: 846 IILWELGTGELPYSGLDSVQLALAVTTKSLRPPIPNAWPYQLSHLIQACWHQDPLKRPSF 905
Query: 731 AEIVNLL 751
EI+NLL
Sbjct: 906 TEILNLL 912
>sp|Q55A09|Y9963_DICDI Probable serine/threonine-protein kinase DDB_G0272254
OS=Dictyostelium discoideum GN=DDB_G0272254 PE=3 SV=1
Length = 1331
Score = 196 bits (497), Expect = 3e-049
Identities = 105/252 (41%), Positives = 154/252 (61%), Gaps = 10/252 (3%)
Frame = +2
Query: 11 QGAFGKLYRGTYKGEDVAIKLLERPENSPEKAQALEQQFQQEVSMLSFLKHPNIVRFIGA 190
+G F K+ +G +KG+DVA+K L N + + + Q+F+ EV +L L+HPN+V G
Sbjct: 1081 KGHFSKVLKGNWKGKDVAVKKLN--SNKDKAREEMIQEFKAEVELLGSLQHPNLVTCYGY 1138
Query: 191 CIKPMVLCIVTEYAKGGSVRQFLTKR---QNRAVPL--KLAVKQALDVARGMAYVHERNF 355
+ PM CIV E+ G++ + + + Q +++ L L + A D+ARGM ++H RN
Sbjct: 1139 SLNPM--CIVMEFLPSGNLFELIHSKPSEQQQSIKLDSTLILAIAFDIARGMQHLHTRNI 1196
Query: 356 IHRDLKSDNLLISADRSIKIADFGVARIEVQTEGMTPETGTYRWMAPEMIQHRPYTQKVD 535
IHRDLKS NLL+ +IKIAD G+AR T+ MT GT W APE+++H Y QK D
Sbjct: 1197 IHRDLKSSNLLMDKHFNIKIADLGIARETSFTQTMT-TIGTVAWTAPEILRHESYNQKAD 1255
Query: 536 VYSFGIVLWELITGLLPFQNMTAVQAAFAVVNRGVRPTVPADCLPVLGEIMTRCWDADPE 715
VYS+ IVL+EL+TG P+Q + + A V ++G+RP +P +C P +++ CW DP
Sbjct: 1256 VYSYAIVLYELLTGEEPYQGIPPMNAGILVASKGLRPELPDNCDPNWKKLVVWCWSEDPN 1315
Query: 716 VRPCFAEIVNLL 751
RP F EI N L
Sbjct: 1316 KRPSFEEITNYL 1327
>sp|Q9NYL2|MLTK_HUMAN Mitogen-activated protein kinase kinase kinase MLT OS=Homo
sapiens GN=MLTK PE=1 SV=2
Length = 800
Score = 180 bits (455), Expect = 2e-044
Identities = 99/276 (35%), Positives = 156/276 (56%), Gaps = 27/276 (9%)
Frame = +2
Query: 14 GAFGKLYRGTYKGED--VAIKLLERPENSPEKAQALEQQFQQEVSMLSFLKHPNIVRFIG 187
G+FG +YR + +D VA+K L + ++E +LS L H NI++F G
Sbjct: 25 GSFGSVYRAKWISQDKEVAVKKL--------------LKIEKEAEILSVLSHRNIIQFYG 70
Query: 188 ACIKPMVLCIVTEYAKGGSVRQFLTKRQNRAVPLKLAVKQALDVARGMAYVHER---NFI 358
++P IVTEYA GS+ ++ ++ + + + A DVA+GM Y+H I
Sbjct: 71 VILEPPNYGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVAKGMHYLHMEAPVKVI 130
Query: 359 HRDLKSDNLLISADRSIKIADFGVARIEVQTEGMTPETGTYRWMAPEMIQHRPYTQKVDV 538
HRDLKS N++I+AD +KI DFG +R T M+ GT+ WMAPE+IQ P ++ D
Sbjct: 131 HRDLKSRNVVIAADGVLKICDFGASRFHNHTTHMS-LVGTFPWMAPEVIQSLPVSETCDT 189
Query: 539 YSFGIVLWELITGLLPFQNMTAVQAAFAVVNRGVRPTVPADCLPVLGEIMTRCWDADPEV 718
YS+G+VLWE++T +PF+ + +Q A+ VV + R T+P+ C E++ +CW+AD +
Sbjct: 190 YSYGVVLWEMLTREVPFKGLEGLQVAWLVVEKNERLTIPSSCPRSFAELLHQCWEADAKK 249
Query: 719 RPCFAEIVNLLEGAETEVMTTVR-------KARFRC 805
RP F +I+++LE + + KA +RC
Sbjct: 250 RPSFKQIISILESMSNDTSLPDKCNSFLHNKAEWRC 285
>sp|Q16584|M3K11_HUMAN Mitogen-activated protein kinase kinase kinase 11 OS=Homo
sapiens GN=MAP3K11 PE=1 SV=1
Length = 847
Score = 178 bits (449), Expect = 1e-043
Identities = 100/271 (36%), Positives = 155/271 (57%), Gaps = 17/271 (6%)
Frame = +2
Query: 20 FGKLYRGTYKGEDVAIKLLERPENSPEKAQALEQQFQQEVSMLSFLKHPNIVRFIGACIK 199
FGK+YRG+++GE VA+K ++ E + +QE + + L HPNI+ C++
Sbjct: 128 FGKVYRGSWRGELVAVKAAR--QDPDEDISVTAESVRQEARLFAMLAHPNIIALKAVCLE 185
Query: 200 PMVLCIVTEYAKGGSVRQFLTKRQNRAVPLKLAVKQALDVARGMAYVHERNF---IHRDL 370
LC+V EYA GG + + L R VP + V A+ +ARGM Y+H IHRDL
Sbjct: 186 EPNLCLVMEYAAGGPLSRALA---GRRVPPHVLVNWAVQIARGMHYLHCEALVPVIHRDL 242
Query: 371 KSDNLL----ISAD----RSIKIADFGVARIEVQTEGMTPETGTYRWMAPEMIQHRPYTQ 526
KS+N+L I +D +++KI DFG+AR +T M+ GTY WMAPE+I+ +++
Sbjct: 243 KSNNILLLQPIESDDMEHKTLKITDFGLAREWHKTTQMS-AAGTYAWMAPEVIKASTFSK 301
Query: 527 KVDVYSFGIVLWELITGLLPFQNMTAVQAAFAVVNRGVRPTVPADCLPVLGEIMTRCWDA 706
DV+SFG++LWEL+TG +P++ + + A+ V + +P+ C ++M CW
Sbjct: 302 GSDVWSFGVLLWELLTGEVPYRGIDCLAVAYGVAVNKLTLPIPSTCPEPFAQLMADCWAQ 361
Query: 707 DPEVRPCFAEIVNLLEGAETEVMTTVRKARF 799
DP RP FA I+ LE E +V+ + + F
Sbjct: 362 DPHRRPDFASILQQLEALEAQVLREMPRDSF 392
>sp|Q80XI6|M3K11_MOUSE Mitogen-activated protein kinase kinase kinase 11 OS=Mus
musculus GN=Map3k11 PE=1 SV=1
Length = 850
Score = 177 bits (448), Expect = 1e-043
Identities = 98/271 (36%), Positives = 153/271 (56%), Gaps = 17/271 (6%)
Frame = +2
Query: 20 FGKLYRGTYKGEDVAIKLLERPENSPEKAQALEQQFQQEVSMLSFLKHPNIVRFIGACIK 199
FGK+YRG+++GE VA+K ++ E + +QE + + L HPNI+ C++
Sbjct: 129 FGKVYRGSWRGELVAVKAAR--QDPDEDISVTAESVRQEARLFAMLAHPNIIALKAVCLE 186
Query: 200 PMVLCIVTEYAKGGSVRQFLTKRQNRAVPLKLAVKQALDVARGMAYVHERNF---IHRDL 370
LC+V EYA GG + + L R VP + V A+ +ARGM Y+H IHRDL
Sbjct: 187 EPNLCLVMEYAAGGPLSRALA---GRRVPPHVLVNWAVQIARGMHYLHCEALVPVIHRDL 243
Query: 371 KSDNLLI--------SADRSIKIADFGVARIEVQTEGMTPETGTYRWMAPEMIQHRPYTQ 526
KS+N+L+ +++KI DFG+AR +T M+ GTY WMAPE+I+ +++
Sbjct: 244 KSNNILLLQPIEGDDMEHKTLKITDFGLAREWHKTTQMS-AAGTYAWMAPEVIKASTFSK 302
Query: 527 KVDVYSFGIVLWELITGLLPFQNMTAVQAAFAVVNRGVRPTVPADCLPVLGEIMTRCWDA 706
DV+SFG++LWEL+TG +P++ + + A+ V + +P+ C ++M CW
Sbjct: 303 GSDVWSFGVLLWELLTGEVPYRGIDCLAVAYGVAVNKLTLPIPSTCPEPFAQLMADCWAQ 362
Query: 707 DPEVRPCFAEIVNLLEGAETEVMTTVRKARF 799
DP RP FA I+ LE E +V+ + + F
Sbjct: 363 DPHRRPDFASILQQLEALEAQVLREMPRDSF 393
>sp|Q66HA1|M3K11_RAT Mitogen-activated protein kinase kinase kinase 11 OS=Rattus
norvegicus GN=Map3k11 PE=2 SV=1
Length = 850
Score = 177 bits (448), Expect = 1e-043
Identities = 98/271 (36%), Positives = 153/271 (56%), Gaps = 17/271 (6%)
Frame = +2
Query: 20 FGKLYRGTYKGEDVAIKLLERPENSPEKAQALEQQFQQEVSMLSFLKHPNIVRFIGACIK 199
FGK+YRG+++GE VA+K ++ E + +QE + + L HPNI+ C++
Sbjct: 129 FGKVYRGSWRGELVAVKAAR--QDPDEDISVTAESVRQEARLFAMLAHPNIIALKAVCLE 186
Query: 200 PMVLCIVTEYAKGGSVRQFLTKRQNRAVPLKLAVKQALDVARGMAYVHERNF---IHRDL 370
LC+V EYA GG + + L R VP + V A+ +ARGM Y+H IHRDL
Sbjct: 187 EPNLCLVMEYAAGGPLSRALA---GRRVPPHVLVNWAVQIARGMHYLHCEALVPVIHRDL 243
Query: 371 KSDNLLI--------SADRSIKIADFGVARIEVQTEGMTPETGTYRWMAPEMIQHRPYTQ 526
KS+N+L+ +++KI DFG+AR +T M+ GTY WMAPE+I+ +++
Sbjct: 244 KSNNILLLQPIEGDDMEHKTLKITDFGLAREWHKTTQMS-AAGTYAWMAPEVIKASTFSK 302
Query: 527 KVDVYSFGIVLWELITGLLPFQNMTAVQAAFAVVNRGVRPTVPADCLPVLGEIMTRCWDA 706
DV+SFG++LWEL+TG +P++ + + A+ V + +P+ C ++M CW
Sbjct: 303 GSDVWSFGVLLWELLTGEVPYRGIDCLAVAYGVAVNKLTLPIPSTCPEPFAQLMADCWAQ 362
Query: 707 DPEVRPCFAEIVNLLEGAETEVMTTVRKARF 799
DP RP FA I+ LE E +V+ + + F
Sbjct: 363 DPHRRPDFASILQQLEALEAQVLREMPRDSF 393
>sp|Q9ESL4|MLTK_MOUSE Mitogen-activated protein kinase kinase kinase MLT OS=Mus
musculus GN=Mltk PE=1 SV=1
Length = 802
Score = 174 bits (440), Expect = 1e-042
Identities = 88/231 (38%), Positives = 143/231 (61%), Gaps = 6/231 (2%)
Frame = +2
Query: 92 SPEKAQALEQ--QFQQEVSMLSFLKHPNIVRFIGACIKPMVLCIVTEYAKGGSVRQFLTK 265
S +K A+++ + ++E +LS L H NI++F G ++P IVTEYA GS+ ++
Sbjct: 37 SQDKEVAVKKLLKIEKEAEILSVLSHRNIIQFYGVILEPPNYGIVTEYASLGSLYDYINS 96
Query: 266 RQNRAVPLKLAVKQALDVARGMAYVHER---NFIHRDLKSDNLLISADRSIKIADFGVAR 436
++ + ++ + A DVA+GM Y+H IHRDLKS N++I+AD +KI DFG +R
Sbjct: 97 NRSEEMDMEHIMTWATDVAKGMHYLHMEAPVKVIHRDLKSRNVVIAADGVLKICDFGASR 156
Query: 437 IEVQTEGMTPETGTYRWMAPEMIQHRPYTQKVDVYSFGIVLWELITGLLPFQNMTAVQAA 616
T M+ GT+ WMAPE+IQ P ++ D YS+G+VLWE++T +PF+ + +Q A
Sbjct: 157 FHNHTTHMS-LVGTFPWMAPEVIQSLPVSETCDTYSYGVVLWEMLTREVPFKGLEGLQVA 215
Query: 617 FAVVNRGVRPTVPADCLPVLGEIMTRCWDADPEVRPCFAEIVNLLEGAETE 769
+ VV + R T+P+ C E++ +CW+AD + RP F +I+++LE +
Sbjct: 216 WLVVEKNERLTIPSSCPRSFAELLHQCWEADAKKRPSFKQIISILESMSND 266
>sp|Q95UN8|M3KSL_DROME Mitogen-activated protein kinase kinase kinase
OS=Drosophila melanogaster GN=slpr PE=1 SV=1
Length = 1161
Score = 174 bits (439), Expect = 2e-042
Identities = 100/273 (36%), Positives = 143/273 (52%), Gaps = 19/273 (6%)
Frame = +2
Query: 14 GAFGKLYRGTYKGEDVAIKLLERPENSPEKAQALEQQFQQEVSMLSFLKHPNIVRFIGAC 193
G F K++RG Y GE+VAIK+ + + Q + QE + LKH NI G C
Sbjct: 151 GGFCKVHRGYYDGEEVAIKIAH--QTGEDDMQRMRDNVLQEAKLFWALKHENIAALRGVC 208
Query: 194 IKPMVLCIVTEYAKGGSVRQFLTKRQNRAVPLKLAVKQALDVARGMAYVHER---NFIHR 364
+ LC+V EYA+GGS+ + L + +P + V A+ +ARGM Y+H + IHR
Sbjct: 209 LNTK-LCLVMEYARGGSLNRILAGK----IPPDVLVNWAIQIARGMNYLHNEAPMSIIHR 263
Query: 365 DLKSDNLLI--------SADRSIKIADFGVARIEVQTEGMTPETGTYRWMAPEMIQHRPY 520
DLKS N+LI +++KI DFG+AR T+ M+ GTY WM PE+I Y
Sbjct: 264 DLKSSNVLIYEAIEGNHLQQKTLKITDFGLAREMYNTQRMS-AAGTYAWMPPEVISVSTY 322
Query: 521 TQKVDVYSFGIVLWELITGLLPFQNMTAVQAAFAVVNRGVRPTVPADCLPVLGEIMTRCW 700
++ DV+S+G++LWELITG P++ + A+ V + +P C G +M CW
Sbjct: 323 SKFSDVWSYGVLLWELITGETPYKGFDPLSVAYGVAVNTLTLPIPKTCPETWGALMKSCW 382
Query: 701 DADPEVRPCFAEIVNLLEGAETEVMTTVRKARF 799
DP RP F EI+ LE T + F
Sbjct: 383 QTDPHKRPGFKEILKQLESIACSKFTLTPQESF 415
>sp|Q54I36|PYK3_DICDI Dual specificity protein kinase pyk3 OS=Dictyostelium
discoideum GN=pyk3 PE=1 SV=1
Length = 1338
Score = 161 bits (406), Expect = 1e-038
Identities = 86/216 (39%), Positives = 130/216 (60%), Gaps = 10/216 (4%)
Frame = +2
Query: 116 EQQFQQEVSMLSFLKHPNIVRFIGACIKPMVLCIVTEYAKGGSVRQFLTKRQNRAVPLKL 295
+++F +EVS L HPN+V F+GACI P CI TEY +GGS+ L ++ + PL +
Sbjct: 1094 DEKFIKEVSSLIKSHHPNVVTFMGACIDPP--CIFTEYLQGGSLYDVLHIQKIKLNPL-M 1150
Query: 296 AVKQALDVARGMAYVHERNFIHRDLKSDNLLISADRSIKIADFGVARI---EVQTEGMTP 466
K D++ GM ++H +HRDL S N+L+ ++IKIADFG+A ++ G+T
Sbjct: 1151 MYKMIHDLSLGMEHLHSIQMLHRDLTSKNILLDEFKNIKIADFGLATTLSDDMTLSGIT- 1209
Query: 467 ETGTYRWMAPEMIQHRPYTQKVDVYSFGIVLWELITGLLPFQNMTAVQAAFAVVNRGVRP 646
RW +PE+ + Y +KVDVYSFG+V++E+ TG +PF+ + +A RP
Sbjct: 1210 ---NPRWRSPELTKGLVYNEKVDVYSFGLVVYEIYTGKIPFEGLDGTASAAKAAFENYRP 1266
Query: 647 TVPADCLPVLGEIMTRCWDADPEVRPCFAEIVNLLE 754
+P DC L +++T+CW +DP RP F EI+ LE
Sbjct: 1267 AIPPDCPVSLRKLITKCWASDPSQRPSFTEILTELE 1302
>sp|Q54L00|LIMKA_DICDI Probable LIM domain-containing serine/threonine-protein
kinase DDB_G0287001 OS=Dictyostelium discoideum GN=DDB_G0287001 PE=3
SV=1
Length = 650
Score = 161 bits (405), Expect = 1e-038
Identities = 96/252 (38%), Positives = 143/252 (56%), Gaps = 10/252 (3%)
Frame = +2
Query: 8 AQGAFGKLYRGTYKGEDVAIKLLERPENSPEKAQALEQQFQQEVSMLSFL--KHPNIVRF 181
A GA GK+Y+G YKG DVAIK+ S E ++F +EV+++S + HPN RF
Sbjct: 393 ASGASGKVYKGIYKGRDVAIKVY-----SSENFCFNIEEFDREVTIMSLIDSDHPNFTRF 447
Query: 182 IGACIK-PMVLCIVTEYAKGGSVRQFLTKRQNRAVPLKLAVKQALDVARGMAYVHERNFI 358
GA + L V+E K GS+R L ++ + + + A D+A M ++H I
Sbjct: 448 YGANKQNKKYLFHVSELVKSGSLRDLLLDKE-KPLAYFTQLSIASDIANAMKHLHSIGVI 506
Query: 359 HRDLKSDNLLISADRSIKIADFGVARIEVQTEGMTPETGTYRWMAPEMIQHRPYTQKVDV 538
HRDLKS N+LI+ D + K+ DFG +R + MT GT +M+PE+ + Y + DV
Sbjct: 507 HRDLKSLNVLITEDFTAKVIDFGTSRNVDLAKQMTLNLGTSCYMSPELFKGNGYDETCDV 566
Query: 539 YSFGIVLWELITGLLPFQNMTAVQAAFAVVNRGVRPTVPADCLPVLGEIMTRCWDADPEV 718
Y+FGIVLWE+I P++N+ + +V +G RPT+PADC +++ CW P+
Sbjct: 567 YAFGIVLWEIIARKEPYENINSWSIP-VLVAKGERPTIPADCPSEYSKLIKACWTDKPKK 625
Query: 719 RPCFAEIVNLLE 754
RP F EI + L+
Sbjct: 626 RPSFKEICDTLK 637
>sp|P0CD62|LIMKB_DICDI Probable LIM domain-containing serine/threonine-protein
kinase DDB_G0286997 OS=Dictyostelium discoideum GN=DDB_G0286997 PE=3
SV=1
Length = 966
Score = 159 bits (400), Expect = 5e-038
Identities = 96/252 (38%), Positives = 142/252 (56%), Gaps = 10/252 (3%)
Frame = +2
Query: 8 AQGAFGKLYRGTYKGEDVAIKLLERPENSPEKAQALEQQFQQEVSMLSFL--KHPNIVRF 181
A GA GK+Y+G YKG DVAIK+ S E +F +EV+++S + HPN RF
Sbjct: 709 AAGASGKVYKGIYKGRDVAIKVY-----SSENFCFNIDEFDREVTIMSLIDSDHPNFTRF 763
Query: 182 IGACIK-PMVLCIVTEYAKGGSVRQFLTKRQNRAVPLKLAVKQALDVARGMAYVHERNFI 358
GA + L V+E K GS+R L ++ + + + A D+A M ++H I
Sbjct: 764 YGANKQNKKYLFHVSELVKSGSLRDLLLDKE-KPLLYFTQLSIASDIANAMKHLHSIGVI 822
Query: 359 HRDLKSDNLLISADRSIKIADFGVARIEVQTEGMTPETGTYRWMAPEMIQHRPYTQKVDV 538
HRDLKS N+LI+ D + K+ DFG +R + MT GT +M+PE+ + Y + DV
Sbjct: 823 HRDLKSLNVLITEDFTAKVIDFGTSRNVDLAKHMTMNLGTSCYMSPELFKGNGYDETCDV 882
Query: 539 YSFGIVLWELITGLLPFQNMTAVQAAFAVVNRGVRPTVPADCLPVLGEIMTRCWDADPEV 718
Y+FGIVLWE+I P++N+ + +V +G RPT+PADC +++ CW P+
Sbjct: 883 YAFGIVLWEIIARKEPYENINSWSIP-VMVAKGDRPTIPADCPSEYSKLIKACWTDKPKK 941
Query: 719 RPCFAEIVNLLE 754
RP F EI + L+
Sbjct: 942 RPSFKEICDTLK 953
>sp|Q54TA1|DRKC_DICDI Probable serine/threonine-protein kinase drkC
OS=Dictyostelium discoideum GN=drkC PE=3 SV=1
Length = 749
Score = 156 bits (393), Expect = 3e-037
Identities = 88/218 (40%), Positives = 127/218 (58%), Gaps = 10/218 (4%)
Frame = +2
Query: 122 QFQQEVSMLSFLKHPNIVRFIGACIKPMVLCIVTEYAKGGSVRQFLTKRQNRAVPLKLAV 301
+ QE +++S L+HPNI +F+G C P + IV EY GS+ + L + ++
Sbjct: 533 ELAQEATIMSQLRHPNICQFLGTCNNPPEILIVMEYMPLGSLYRIL-HDPSISLDWPRMK 591
Query: 302 KQALDVARGMAYVH--ERNFIHRDLKSDNLLISADRSIKIADFGVA-----RIEVQTEGM 460
ALD+A+GM Y+H + IHRDLKS NLL+ +KI+DFG++ ++ +T M
Sbjct: 592 SMALDIAKGMNYLHCCDPIVIHRDLKSHNLLVDEHYRVKISDFGLSTRFKKHLDKKT-AM 650
Query: 461 TPETGTYRWMAPEMIQHRPYTQKVDVYSFGIVLWELITGLLPFQNMTAVQAAFAVVNRGV 640
TP GT W APE++++ PYT+K DV+SF IVLWE++T P+Q M Q +V +
Sbjct: 651 TP-VGTPCWTAPEVLRNDPYTEKADVFSFAIVLWEIVTREDPYQGMPTFQIVISVGQHKL 709
Query: 641 RPTVPADCLPVLGEIMTRCWDADPEVRPCFAEIVNLLE 754
RP VP ++T CW DP+ RP F EIV LE
Sbjct: 710 RPIVPPQVSAPFTRLITECWSEDPQQRPSFQEIVKRLE 747
>sp|Q5UQG7|YR818_MIMIV Putative serine/threonine-protein kinase/receptor R818
OS=Acanthamoeba polyphaga mimivirus GN=MIMI_R818 PE=4 SV=1
Length = 1651
Score = 155 bits (391), Expect = 6e-037
Identities = 81/260 (31%), Positives = 145/260 (55%), Gaps = 14/260 (5%)
Frame = +2
Query: 2 AFAQGAFGKLYRGTYKGEDVAIKLLERPENSPEKAQALEQQFQQEVSMLSFLKHPNIVRF 181
+ G G++++ +KG +VA+K L + + E+ F+QE+ ++ L+HPN+V F
Sbjct: 798 SLGSGGSGEVFKAMWKGTEVAVKKLVNSNITKD----AERNFKQEIHRMTSLRHPNVVLF 853
Query: 182 IGACIKPMVLCIVTEYAKGGSVRQFLTKRQNRAVPLKLAVKQALDVARGMAYVHERNFIH 361
+ A +P +CIV E+ GS+ L +P L ++ A A+GM ++H + +H
Sbjct: 854 MAASTRPPNMCIVMEFMSLGSLYDLLGNELVTEIPPVLRIRIAYQAAKGMHFLHSSDIVH 913
Query: 362 RDLKSDNLLISADRSIKIADFGVARIEVQTEGMT----PETGTYRWMAPEMIQHRPYTQK 529
RDLKS NLL+ + ++K++DFG+ +I+ +G + + +W APE++ +
Sbjct: 914 RDLKSLNLLLDSKWNVKVSDFGLTKIKDNNKGKSSTKEDSVCSIQWTAPEVLSEKQDIDY 973
Query: 530 V--DVYSFGIVLWELITGLLPFQNMTAVQAAFAVVNRGVRPTVPADCLPVLG----EIMT 691
+ DVYSFGI++WEL+T L P+ ++ A AV+ +RP + + + ++ E++
Sbjct: 974 ILADVYSFGIIMWELMTRLRPYIGLSPAAIAVAVIRDNLRPEIQEEDINLMSSDYVELVN 1033
Query: 692 RCWDADPEVRPCFAEIVNLL 751
CW D +RP F EI+ L
Sbjct: 1034 ICWHKDTMIRPSFLEIMTKL 1053
>sp|Q7T6X2|YR826_MIMIV Putative serine/threonine-protein kinase/receptor R826
OS=Acanthamoeba polyphaga mimivirus GN=MIMI_R826 PE=4 SV=2
Length = 1657
Score = 155 bits (391), Expect = 6e-037
Identities = 80/219 (36%), Positives = 130/219 (59%), Gaps = 11/219 (5%)
Frame = +2
Query: 14 GAFGKLYRGTYKGEDVAIKLLERPENSPEK--AQALEQQFQQEVSMLSFLKHPNIVRFIG 187
GAFG++++GT++G +VA+K++ SP+K + +E+ F+ EV +++ L+HPN+V F+
Sbjct: 795 GAFGEVHKGTWRGTEVAVKMI-----SPDKTITKDIERNFKDEVRVMTTLRHPNVVLFMA 849
Query: 188 ACIKPMVLCIVTEYAKGGSVRQFLTKRQNRAVPLKLAVKQALDVARGMAYVHERNFIHRD 367
A KP +CIV E+ GS+ L +P L VK A ++GM ++H HRD
Sbjct: 850 ASTKPPKMCIVMEFMALGSLHDLLKNELIPDIPFALKVKIAYQASKGMHFLHSSGITHRD 909
Query: 368 LKSDNLLISADRSIKIADFGVARIEVQTEGMTPE--TGTYRWMAPEMIQHRPYTQKV--D 535
LKS NLL+ ++K++DFG+ + + + + PE GT +W APE++ + D
Sbjct: 910 LKSLNLLLDIKWNVKVSDFGLTKFKSDVKSINPEKFAGTIQWTAPEILSEDREVDYILSD 969
Query: 536 VYSFGIVLWELITGLLPFQNMTAVQAAFAVVNRGVRPTV 652
VYSFGI++WELIT P+ M+ A +V+ RP +
Sbjct: 970 VYSFGIIMWELITRDQPYFGMSPAAIAVSVIRDNYRPVI 1008
>sp|Q54RZ7|Y1199_DICDI Probable serine/threonine-protein kinase DDB_G0282895
OS=Dictyostelium discoideum GN=DDB_G0282895 PE=3 SV=1
Length = 1634
Score = 153 bits (385), Expect = 3e-036
Identities = 84/252 (33%), Positives = 147/252 (58%), Gaps = 12/252 (4%)
Frame = +2
Query: 11 QGAFGKLYRGTYKGEDVAIKLLERPENSPEKAQALEQQFQQEVSMLSFLKHPNIVRFIGA 190
+GA ++++G +KG++VA+K+ N + LE F +EV++L + HPN+++ GA
Sbjct: 1385 EGALAEVHKGIWKGKEVAVKIF----NEGSFSFRLE-DFLKEVAILGLISHPNLLKLKGA 1439
Query: 191 CIKP----MVLCIVTEYAKGGSVRQFLTKRQNRAVPLKLAVKQALDVARGMAYVHERNFI 358
CI P IVTE G++ + + K N+ + L+ +K AL VA+G+AY+H +FI
Sbjct: 1440 CIAPRSHKSTFMIVTELMHKGTLLEVINK--NKPLSLEDIIKYALSVAQGLAYLHSVDFI 1497
Query: 359 HRDLKSDNLLISADRSIKIADFGVARIEVQTEGMTPETGTYRWMAPEMIQHRPYTQKVDV 538
HRD+K+ N+L+ + + K+ DFG++R+ MT GT +W +PE + YT DV
Sbjct: 1498 HRDIKAANILVDKNNNAKVGDFGLSRVIDNNFNMTAVAGTPKWESPECLMGEAYTSASDV 1557
Query: 539 YSFGIVLWELITGLLPF-QNMTAVQAAFAVVNRGVRPTVPADCLPVLGEIMTRCWDADPE 715
YS+G++L+EL TG PF + + V+ A +V ++ ++P + + + ++ C P+
Sbjct: 1558 YSYGMMLFELATGDEPFLEIQSIVELARSVCDKKLKPKISSSVPNFISSLIKDCLHNSPK 1617
Query: 716 VRPCFAEIVNLL 751
RP +I+ L
Sbjct: 1618 KRPTMNQIIQKL 1629
>sp|Q7T6Y2|YR831_MIMIV Putative serine/threonine-protein kinase/receptor R831
OS=Acanthamoeba polyphaga mimivirus GN=MIMI_R831 PE=4 SV=2
Length = 1624
Score = 151 bits (380), Expect = 1e-035
Identities = 75/218 (34%), Positives = 129/218 (59%), Gaps = 9/218 (4%)
Frame = +2
Query: 14 GAFGKLYRGTYKGEDVAIKLLERPENSPEKAQALEQQFQQEVSMLSFLKHPNIVRFIGAC 193
G +G++Y+ +KG +VA+KL+ +S ++ +E+ F +EV +++ L+HPN+V F+ A
Sbjct: 795 GGYGEVYKSIWKGTEVAVKLI----SSKHVSKDMERSFFEEVKIMTSLRHPNVVLFMAAS 850
Query: 194 IKPMVLCIVTEYAKGGSVRQFLTKRQNRAVPLKLAVKQALDVARGMAYVHERNFIHRDLK 373
K +CIV E+ GS+ L +P L +K A ++GM ++H +HRDLK
Sbjct: 851 TKSPNMCIVMEFMSLGSLYDLLGNELIPEIPYALKIKMAYQASKGMHFLHSSGIVHRDLK 910
Query: 374 SDNLLISADRSIKIADFGVARIEVQTEGMTPE---TGTYRWMAPEMIQHRPYTQKV--DV 538
S NLL+ + ++K++DFG+ +++ + + GT W+APE++ + DV
Sbjct: 911 SLNLLLDSKWNVKVSDFGLTKVKSELDKKKTNDNIIGTIHWIAPEILNDSTEVDYILADV 970
Query: 539 YSFGIVLWELITGLLPFQNMTAVQAAFAVVNRGVRPTV 652
YSFGI+LWEL+T P++ MT A +V+ G+RP +
Sbjct: 971 YSFGIILWELLTREQPYKGMTPAAIAVSVIRDGMRPPI 1008
>sp|P00522|ABL_DROME Tyrosine-protein kinase Abl OS=Drosophila melanogaster
GN=Abl PE=1 SV=3
Length = 1620
Score = 146 bits (366), Expect = 5e-034
Identities = 81/253 (32%), Positives = 139/253 (54%), Gaps = 15/253 (5%)
Frame = +2
Query: 14 GAFGKLYRGTYK--GEDVAIKLLERPENSPEKAQALEQQFQQEVSMLSFLKHPNIVRFIG 187
G +G++Y +K G VA+K L+ E AL + F +E +++ +KHPN+V+ IG
Sbjct: 380 GQYGEVYEAVWKRYGNTVAVKTLK------EDTMAL-KDFLEEAAIMKEMKHPNLVQLIG 432
Query: 188 ACIKPMVLCIVTEYAKGGSVRQFLTKRQNRAVPLKLAVKQALDVARGMAYVHERNFIHRD 367
C + I+TE+ G++ FL + + A +A GM+Y+ RN+IHRD
Sbjct: 433 VCTREPPFYIITEFMSHGNLLDFLRSAGRETLDAVALLYMATQIASGMSYLESRNYIHRD 492
Query: 368 LKSDNLLISADRSIKIADFGVARIEVQTEGMTPETGT---YRWMAPEMIQHRPYTQKVDV 538
L + N L+ ++ +K+ADFG+AR+ ++ + T G +W APE + + ++ K DV
Sbjct: 493 LAARNCLVGDNKLVKVADFGLARL-MRDDTYTAHAGAKFPIKWTAPEGLAYNKFSTKSDV 551
Query: 539 YSFGIVLWELIT-GLLPFQNMTAVQAAFAVVNRGVRPTVPADCLPVLGEIMTRCWDADPE 715
++FG++LWE+ T G+ P+ + + +++G R P C P + ++M +CW D
Sbjct: 552 WAFGVLLWEIATYGMSPYPAIDLTD-VYHKLDKGYRMERPPGCPPEVYDLMRQCWQWDAT 610
Query: 716 VRPCFAEIVNLLE 754
RP F I + LE
Sbjct: 611 DRPTFKSIHHALE 623
>sp|P18161|PYK2_DICDI Dual specificity protein kinase pyk2 OS=Dictyostelium
discoideum GN=splB PE=2 SV=2
Length = 1155
Score = 129 bits (324), Expect = 3e-029
Identities = 65/158 (41%), Positives = 99/158 (62%), Gaps = 4/158 (2%)
Frame = +2
Query: 293 LAVKQALDVARGMAYVHERNFIHRDLKSDNLLISADRSIKIADFGVARIEVQTEGMTPET 472
L +K A D+A G+ ++H +HRDL S N+L+ +IKI+DFG++R + + MT
Sbjct: 953 LVLKMATDMALGLLHLHSITIVHRDLTSQNILLDELGNIKISDFGLSREKSREGSMTMTN 1012
Query: 473 G---TYRWMAPEMIQH-RPYTQKVDVYSFGIVLWELITGLLPFQNMTAVQAAFAVVNRGV 640
G RW PE+ ++ Y++KVDVY F +V+WE++TG +PF ++ QA+ V G+
Sbjct: 1013 GGICNPRWRPPELTKNLGHYSEKVDVYCFSLVVWEILTGEIPFSDLDGSQASAQVAYAGL 1072
Query: 641 RPTVPADCLPVLGEIMTRCWDADPEVRPCFAEIVNLLE 754
RP +P C P L ++T+CW+ADP RP F IVN L+
Sbjct: 1073 RPPIPEYCDPELKLLLTQCWEADPNDRPPFTYIVNKLK 1110
>sp|Q8VDG6|M3KL4_MOUSE Mitogen-activated protein kinase kinase kinase OS=Mus
musculus GN=Mlk4 PE=2 SV=2
Length = 1002
Score = 103 bits (255), Expect = 3e-021
Identities = 47/134 (35%), Positives = 82/134 (61%), Gaps = 1/134 (0%)
Frame = +2
Query: 398 DRSIKIADFGVARIEVQTEGMTPETGTYRWMAPEMIQHRPYTQKVDVYSFGIVLWELITG 577
++++KI DFG+AR +T M+ GTY WMAPE+I+ +++ D++S+G++LWEL+TG
Sbjct: 266 NKTLKITDFGLAREWHRTTRMS-AAGTYAWMAPEVIRSSLFSKGSDIWSYGVLLWELLTG 324
Query: 578 LLPFQNMTAVQAAFAVVNRGVRPTVPADCLPVLGEIMTRCWDADPEVRPCFAEIVNLLEG 757
+P++ + + A+ V + +P+ C ++M CW+ DP +RP FA I+ L
Sbjct: 325 EVPYRGIDGLAVAYGVAVNKLTLPIPSTCPEPFAKLMKECWEQDPHIRPSFALILQQLTA 384
Query: 758 AETEVMTTVRKARF 799
E V+T + + F
Sbjct: 385 IEEAVLTNMPQESF 398
Database: UniProt/SwissProt
Posted date: Sat Aug 07 14:36:18 2010
Number of letters in database: 182,829,261
Number of sequences in database: 518,415
Lambda K H
0.267 0.041 0.140
Gapped
Lambda K H
0.267 0.041 0.140
Matrix: blosum62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 185,567,659,578
Number of Sequences: 518415
Number of Extensions: 185567659578
Number of Successful Extensions: 1125298771
Number of sequences better than 0.0: 0
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