BLASTX 7.6.2
Query= UN49787 /QuerySize=1032
(1031 letters)
Database: UniProt/SwissProt;
518,415 sequences; 182,829,261 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q9M077|AUR1_ARATH Serine/threonine-protein kinase Aurora-1 OS... 376 1e-103
sp|Q683C9|AUR2_ARATH Serine/threonine-protein kinase Aurora-2 OS... 364 1e-099
sp|Q9N0X0|AURKB_PIG Serine/threonine-protein kinase 12 OS=Sus sc... 278 4e-074
sp|P97477|STK6_MOUSE Serine/threonine-protein kinase 6 OS=Mus mu... 277 2e-073
sp|Q54WX4|AURK_DICDI Probable serine/threonine-protein kinase au... 274 1e-072
sp|A5GFW1|STK6_PIG Serine/threonine-protein kinase 6 OS=Sus scro... 272 3e-072
sp|P59241|STK6_RAT Serine/threonine-protein kinase 6 OS=Rattus n... 272 3e-072
sp|Q91819|STK6L_XENLA Serine/threonine-protein kinase Eg2-like O... 272 4e-072
sp|Q91820|STK6_XENLA Serine/threonine-protein kinase 6 OS=Xenopu... 272 4e-072
sp|Q7YRC6|AURKB_BOVIN Serine/threonine-protein kinase 12 OS=Bos ... 270 1e-071
sp|Q96GD4|AURKB_HUMAN Serine/threonine-protein kinase 12 OS=Homo... 270 1e-071
sp|Q2TA06|STK6_BOVIN Serine/threonine-protein kinase 6 OS=Bos ta... 270 2e-071
sp|O14965|STK6_HUMAN Serine/threonine-protein kinase 6 OS=Homo s... 270 2e-071
sp|O70126|AURKB_MOUSE Serine/threonine-protein kinase 12 OS=Mus ... 268 4e-071
sp|O55099|AURKB_RAT Serine/threonine-protein kinase 12 OS=Rattus... 268 7e-071
sp|Q6DE08|AUKBA_XENLA Serine/threonine-protein kinase 12-A OS=Xe... 267 1e-070
sp|Q6GPL3|AUKBB_XENLA Serine/threonine-protein kinase 12-B OS=Xe... 266 2e-070
sp|A4IGM9|AURKB_XENTR Serine/threonine-protein kinase 12 OS=Xeno... 265 4e-070
sp|Q9UQB9|AURKC_HUMAN Serine/threonine-protein kinase 13 OS=Homo... 262 3e-069
sp|O64629|AUR3_ARATH Serine/threonine-protein kinase Aurora-3 OS... 258 6e-068
>sp|Q9M077|AUR1_ARATH Serine/threonine-protein kinase Aurora-1 OS=Arabidopsis
thaliana GN=AUR1 PE=2 SV=1
Length = 294
Score = 376 bits (965), Expect = 1e-103
Identities = 185/196 (94%), Positives = 191/196 (97%), Gaps = 1/196 (0%)
Frame = +3
Query: 87 EKEASDVS-AVAQKRWNLNDFDIGKPLGRGKFGHVYLAREKRSNHIVALKVLFKTQLQQS 263
EKEASD S A AQKRW L+DFDIGKPLGRGKFGHVYLAREKRSNH+VALKVLFK+QLQQS
Sbjct: 11 EKEASDASAAAAQKRWTLSDFDIGKPLGRGKFGHVYLAREKRSNHVVALKVLFKSQLQQS 70
Query: 264 QVEHQLRREVEIQSHLRNPNILRLYGYFYDQERVYLILEYAARGELYKELQKCKYFSERR 443
QVEHQLRREVEIQSHLR+PNILRLYGYFYDQ+RVYLILEYAARGELYK+LQKCKYFSERR
Sbjct: 71 QVEHQLRREVEIQSHLRHPNILRLYGYFYDQKRVYLILEYAARGELYKDLQKCKYFSERR 130
Query: 444 AATYVASLARALIYCHGKHVIHRDIKPENLLIGAQGELKIADFGWSVHTFNRRRTMCGTL 623
AATYVASLARALIYCHGKHVIHRDIKPENLLIGAQGELKIADFGWSVHTFNRRRTMCGTL
Sbjct: 131 AATYVASLARALIYCHGKHVIHRDIKPENLLIGAQGELKIADFGWSVHTFNRRRTMCGTL 190
Query: 624 DYLPPEMVESVEHCAS 671
DYLPPEMVESVEH AS
Sbjct: 191 DYLPPEMVESVEHDAS 206
>sp|Q683C9|AUR2_ARATH Serine/threonine-protein kinase Aurora-2 OS=Arabidopsis
thaliana GN=AUR2 PE=2 SV=2
Length = 282
Score = 364 bits (932), Expect = 1e-099
Identities = 177/188 (94%), Positives = 181/188 (96%)
Frame = +3
Query: 108 SAVAQKRWNLNDFDIGKPLGRGKFGHVYLAREKRSNHIVALKVLFKTQLQQSQVEHQLRR 287
S AQKRW +DFDIGKPLGRGKFGHVYLAREKRS+HIVALKVLFK QLQQSQVEHQLRR
Sbjct: 7 SEAAQKRWTTSDFDIGKPLGRGKFGHVYLAREKRSDHIVALKVLFKAQLQQSQVEHQLRR 66
Query: 288 EVEIQSHLRNPNILRLYGYFYDQERVYLILEYAARGELYKELQKCKYFSERRAATYVASL 467
EVEIQSHLR+PNILRLYGYFYDQ+RVYLILEYA RGELYKELQKCKYFSERRAATYVASL
Sbjct: 67 EVEIQSHLRHPNILRLYGYFYDQKRVYLILEYAVRGELYKELQKCKYFSERRAATYVASL 126
Query: 468 ARALIYCHGKHVIHRDIKPENLLIGAQGELKIADFGWSVHTFNRRRTMCGTLDYLPPEMV 647
ARALIYCHGKHVIHRDIKPENLLIGAQGELKIADFGWSVHTFNRRRTMCGTLDYLPPEMV
Sbjct: 127 ARALIYCHGKHVIHRDIKPENLLIGAQGELKIADFGWSVHTFNRRRTMCGTLDYLPPEMV 186
Query: 648 ESVEHCAS 671
ESVEH AS
Sbjct: 187 ESVEHDAS 194
>sp|Q9N0X0|AURKB_PIG Serine/threonine-protein kinase 12 OS=Sus scrofa GN=AURKB
PE=2 SV=2
Length = 344
Score = 278 bits (711), Expect = 4e-074
Identities = 132/192 (68%), Positives = 162/192 (84%), Gaps = 1/192 (0%)
Frame = +3
Query: 90 KEASDVSAVAQKRWNLNDFDIGKPLGRGKFGHVYLAREKRSNHIVALKVLFKTQLQQSQV 269
+ +S + + + ++DF+IG+PLG+GKFG+VYLAREK+S+ IVALKVLFK+Q+++ V
Sbjct: 59 ENSSGTPNFSTRSFTIDDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGV 118
Query: 270 EHQLRREVEIQSHLRNPNILRLYGYFYDQERVYLILEYAARGELYKELQKCKYFSERRAA 449
EHQLRRE+EIQ+HL++PNILRLY YFYD+ R+YLILEYA RGELYKELQKC+ F E+R A
Sbjct: 119 EHQLRREIEIQAHLQHPNILRLYNYFYDRRRIYLILEYAPRGELYKELQKCRTFDEQRTA 178
Query: 450 TYVASLARALIYCHGKHVIHRDIKPENLLIGAQGELKIADFGWSVHTFN-RRRTMCGTLD 626
T + LA ALIYCHGK VIHRDIKPENLL+G QGELKIADFGWSVH + RR+TMCGTLD
Sbjct: 179 TIMEELADALIYCHGKKVIHRDIKPENLLLGLQGELKIADFGWSVHAPSLRRKTMCGTLD 238
Query: 627 YLPPEMVESVEH 662
YLPPEM+E H
Sbjct: 239 YLPPEMIEGRTH 250
>sp|P97477|STK6_MOUSE Serine/threonine-protein kinase 6 OS=Mus musculus GN=Aurka
PE=1 SV=1
Length = 395
Score = 277 bits (706), Expect = 2e-073
Identities = 135/197 (68%), Positives = 159/197 (80%), Gaps = 4/197 (2%)
Frame = +3
Query: 84 SEKEASDVSA---VAQKRWNLNDFDIGKPLGRGKFGHVYLAREKRSNHIVALKVLFKTQL 254
SEKE + + +++W L DFDIG+PLG+GKFG+VYLARE++S I+ALKVLFKTQL
Sbjct: 101 SEKEQASLQKTEDTKKRQWTLEDFDIGRPLGKGKFGNVYLARERQSKFILALKVLFKTQL 160
Query: 255 QQSQVEHQLRREVEIQSHLRNPNILRLYGYFYDQERVYLILEYAARGELYKELQKCKYFS 434
+++ VEHQLRREVEIQSHLR+PNILRLYGYF+D RVYLILEYA G +Y+ELQK F
Sbjct: 161 EKANVEHQLRREVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFD 220
Query: 435 ERRAATYVASLARALIYCHGKHVIHRDIKPENLLIGAQGELKIADFGWSVHT-FNRRRTM 611
E+R ATY+ LA AL YCH K VIHRDIKPENLL+G+ GELKIADFGWSVH +RR TM
Sbjct: 221 EQRTATYITELANALSYCHSKRVIHRDIKPENLLLGSNGELKIADFGWSVHAPSSRRTTM 280
Query: 612 CGTLDYLPPEMVESVEH 662
CGTLDYLPPEM+E H
Sbjct: 281 CGTLDYLPPEMIEGRMH 297
>sp|Q54WX4|AURK_DICDI Probable serine/threonine-protein kinase aurK
OS=Dictyostelium discoideum GN=aurK PE=1 SV=1
Length = 384
Score = 274 bits (699), Expect = 1e-072
Identities = 134/204 (65%), Positives = 162/204 (79%), Gaps = 1/204 (0%)
Frame = +3
Query: 42 SSARSLSLSSMAIASEKEASDVSAVAQKRWNLNDFDIGKPLGRGKFGHVYLAREKRSNHI 221
SS+ S S SS + +S +S +V +K+W ++DFDIGK LG G+FGHVYLAREK+S I
Sbjct: 76 SSSSSSSSSSSSSSSSSSSSSSQSVPKKKWCIDDFDIGKLLGMGRFGHVYLAREKKSQFI 135
Query: 222 VALKVLFKTQLQQSQVEHQLRREVEIQSHLRNPNILRLYGYFYDQERVYLILEYAARGEL 401
VALKVLFK QLQ +EHQLRRE+EIQSHLR+PNILRL+GYFYD +RV+LI+E+A GE
Sbjct: 136 VALKVLFKNQLQTHNIEHQLRREIEIQSHLRHPNILRLFGYFYDDKRVFLIIEFAKGGEC 195
Query: 402 YKELQKCKYFSERRAATYVASLARALIYCHGKHVIHRDIKPENLLIGAQGELKIADFGWS 581
+KELQK F+E+ AATY +A AL YCH KHVIHRDIKPENLLIG GE+KIADFGWS
Sbjct: 196 FKELQKVGSFNEQTAATYTLQIADALRYCHSKHVIHRDIKPENLLIGVGGEIKIADFGWS 255
Query: 582 VHTFN-RRRTMCGTLDYLPPEMVE 650
VH N +R T CGTL+YLPPE++E
Sbjct: 256 VHAPNTKRSTFCGTLEYLPPEVIE 279
>sp|A5GFW1|STK6_PIG Serine/threonine-protein kinase 6 OS=Sus scrofa GN=AURKA
PE=3 SV=1
Length = 402
Score = 272 bits (695), Expect = 3e-072
Identities = 133/195 (68%), Positives = 160/195 (82%), Gaps = 3/195 (1%)
Frame = +3
Query: 81 ASEKEASDVSAVAQKRWNLNDFDIGKPLGRGKFGHVYLAREKRSNHIVALKVLFKTQLQQ 260
A+ K+ ++ S +++W L DF+IG+PLG+GKFG+VYLAREK+S I+ALKVLFKTQL++
Sbjct: 114 AASKQKNEES--KKRQWALEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKTQLEK 171
Query: 261 SQVEHQLRREVEIQSHLRNPNILRLYGYFYDQERVYLILEYAARGELYKELQKCKYFSER 440
+ VEHQLRREVEIQSHLR+PNILRLYGYF+D RVYLILEYA G +Y+ELQK F E+
Sbjct: 172 AGVEHQLRREVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGAVYRELQKLSKFDEQ 231
Query: 441 RAATYVASLARALIYCHGKHVIHRDIKPENLLIGAQGELKIADFGWSVHT-FNRRRTMCG 617
R ATY+ LA AL YCH K VIHRDIKPENLL+G+ GELKIADFGWSVH +RR T+CG
Sbjct: 232 RTATYITELANALSYCHSKRVIHRDIKPENLLLGSAGELKIADFGWSVHAPSSRRTTLCG 291
Query: 618 TLDYLPPEMVESVEH 662
TLDYLPPEM+E H
Sbjct: 292 TLDYLPPEMIEGRMH 306
>sp|P59241|STK6_RAT Serine/threonine-protein kinase 6 OS=Rattus norvegicus
GN=Aurka PE=1 SV=1
Length = 397
Score = 272 bits (695), Expect = 3e-072
Identities = 133/197 (67%), Positives = 157/197 (79%), Gaps = 4/197 (2%)
Frame = +3
Query: 84 SEKEASDVSAV---AQKRWNLNDFDIGKPLGRGKFGHVYLAREKRSNHIVALKVLFKTQL 254
SEKE + + +++W L DFDIG+PLG+GKFG+VYLAREK+S I+ALKVLFK QL
Sbjct: 103 SEKEQTSIQKTEDSKKRQWTLEDFDIGRPLGKGKFGNVYLAREKQSKFILALKVLFKVQL 162
Query: 255 QQSQVEHQLRREVEIQSHLRNPNILRLYGYFYDQERVYLILEYAARGELYKELQKCKYFS 434
+++ VEHQLRREVEIQSHLR+PNILRLYGYF+D RVYLILEYA G +Y+ELQK F
Sbjct: 163 EKAGVEHQLRREVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFD 222
Query: 435 ERRAATYVASLARALIYCHGKHVIHRDIKPENLLIGAQGELKIADFGWSVHT-FNRRRTM 611
E+R ATY+ LA AL YCH K VIHRDIKPENLL+G+ GELKIADFGWSVH +RR T+
Sbjct: 223 EQRTATYITELANALSYCHSKRVIHRDIKPENLLLGSNGELKIADFGWSVHAPSSRRTTL 282
Query: 612 CGTLDYLPPEMVESVEH 662
CGTLDY PPEM+E H
Sbjct: 283 CGTLDYQPPEMIEGRMH 299
>sp|Q91819|STK6L_XENLA Serine/threonine-protein kinase Eg2-like OS=Xenopus
laevis PE=2 SV=2
Length = 408
Score = 272 bits (694), Expect = 4e-072
Identities = 128/182 (70%), Positives = 155/182 (85%), Gaps = 1/182 (0%)
Frame = +3
Query: 120 QKRWNLNDFDIGKPLGRGKFGHVYLAREKRSNHIVALKVLFKTQLQQSQVEHQLRREVEI 299
+K+W L DF+IG+PLG+GKFG+VYLARE+ S I+ALKVLFK+QL+++ VEHQLRREVEI
Sbjct: 132 KKQWCLEDFEIGRPLGKGKFGNVYLARERESKFILALKVLFKSQLEKAGVEHQLRREVEI 191
Query: 300 QSHLRNPNILRLYGYFYDQERVYLILEYAARGELYKELQKCKYFSERRAATYVASLARAL 479
QSHLR+PNILRLYGYF+D RVYLIL+YA GEL++ELQKC F ++R+A Y+ LA AL
Sbjct: 192 QSHLRHPNILRLYGYFHDASRVYLILDYAPGGELFRELQKCTRFDDQRSALYIKQLAEAL 251
Query: 480 IYCHGKHVIHRDIKPENLLIGAQGELKIADFGWSVHT-FNRRRTMCGTLDYLPPEMVESV 656
+YCH K VIHRDIKPENLL+G+ GELKIADFGWSVH +RR T+CGTLDYLPPEM+E
Sbjct: 252 LYCHSKKVIHRDIKPENLLLGSNGELKIADFGWSVHAPSSRRTTLCGTLDYLPPEMIEGR 311
Query: 657 EH 662
H
Sbjct: 312 MH 313
>sp|Q91820|STK6_XENLA Serine/threonine-protein kinase 6 OS=Xenopus laevis
GN=aurka PE=1 SV=1
Length = 407
Score = 272 bits (694), Expect = 4e-072
Identities = 128/182 (70%), Positives = 155/182 (85%), Gaps = 1/182 (0%)
Frame = +3
Query: 120 QKRWNLNDFDIGKPLGRGKFGHVYLAREKRSNHIVALKVLFKTQLQQSQVEHQLRREVEI 299
+K+W L DF+IG+PLG+GKFG+VYLARE+ S I+ALKVLFK+QL+++ VEHQLRREVEI
Sbjct: 132 KKQWCLEDFEIGRPLGKGKFGNVYLARERESKFILALKVLFKSQLEKAGVEHQLRREVEI 191
Query: 300 QSHLRNPNILRLYGYFYDQERVYLILEYAARGELYKELQKCKYFSERRAATYVASLARAL 479
QSHLR+PNILRLYGYF+D RVYLIL+YA GEL++ELQKC F ++R+A Y+ LA AL
Sbjct: 192 QSHLRHPNILRLYGYFHDASRVYLILDYAPGGELFRELQKCTRFDDQRSAMYIKQLAEAL 251
Query: 480 IYCHGKHVIHRDIKPENLLIGAQGELKIADFGWSVHT-FNRRRTMCGTLDYLPPEMVESV 656
+YCH K VIHRDIKPENLL+G+ GELKIADFGWSVH +RR T+CGTLDYLPPEM+E
Sbjct: 252 LYCHSKKVIHRDIKPENLLLGSNGELKIADFGWSVHAPSSRRTTLCGTLDYLPPEMIEGR 311
Query: 657 EH 662
H
Sbjct: 312 MH 313
>sp|Q7YRC6|AURKB_BOVIN Serine/threonine-protein kinase 12 OS=Bos taurus GN=AURKB
PE=2 SV=1
Length = 344
Score = 270 bits (690), Expect = 1e-071
Identities = 128/192 (66%), Positives = 160/192 (83%), Gaps = 1/192 (0%)
Frame = +3
Query: 90 KEASDVSAVAQKRWNLNDFDIGKPLGRGKFGHVYLAREKRSNHIVALKVLFKTQLQQSQV 269
+ +S + ++ + ++DF+IG+PLG+GKFG+VYLAREK+S+ IVALKVLFK+Q+++ V
Sbjct: 59 ENSSGTPNIPKRSFTIDDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGV 118
Query: 270 EHQLRREVEIQSHLRNPNILRLYGYFYDQERVYLILEYAARGELYKELQKCKYFSERRAA 449
EHQLRRE+EIQ+HL++PNILRLY YFYD+ R+YLILEYA RGELYKELQK + F E+R A
Sbjct: 119 EHQLRREIEIQAHLQHPNILRLYNYFYDRRRIYLILEYAPRGELYKELQKSRTFDEQRTA 178
Query: 450 TYVASLARALIYCHGKHVIHRDIKPENLLIGAQGELKIADFGWSVHTFN-RRRTMCGTLD 626
T + LA AL YCH K VIHRDIKPENLL+G +GELKIADFGWSVH + RR+TMCGTLD
Sbjct: 179 TIMEELADALTYCHAKKVIHRDIKPENLLLGLRGELKIADFGWSVHAPSLRRKTMCGTLD 238
Query: 627 YLPPEMVESVEH 662
YLPPEM+E H
Sbjct: 239 YLPPEMIEGRTH 250
>sp|Q96GD4|AURKB_HUMAN Serine/threonine-protein kinase 12 OS=Homo sapiens
GN=AURKB PE=1 SV=2
Length = 344
Score = 270 bits (690), Expect = 1e-071
Identities = 129/192 (67%), Positives = 159/192 (82%), Gaps = 1/192 (0%)
Frame = +3
Query: 90 KEASDVSAVAQKRWNLNDFDIGKPLGRGKFGHVYLAREKRSNHIVALKVLFKTQLQQSQV 269
+ +S + + + ++DF+IG+PLG+GKFG+VYLAREK+S+ IVALKVLFK+Q+++ V
Sbjct: 59 ENSSGTPDILTRHFTIDDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGV 118
Query: 270 EHQLRREVEIQSHLRNPNILRLYGYFYDQERVYLILEYAARGELYKELQKCKYFSERRAA 449
EHQLRRE+EIQ+HL +PNILRLY YFYD+ R+YLILEYA RGELYKELQK F E+R A
Sbjct: 119 EHQLRREIEIQAHLHHPNILRLYNYFYDRRRIYLILEYAPRGELYKELQKSCTFDEQRTA 178
Query: 450 TYVASLARALIYCHGKHVIHRDIKPENLLIGAQGELKIADFGWSVHTFN-RRRTMCGTLD 626
T + LA AL+YCHGK VIHRDIKPENLL+G +GELKIADFGWSVH + RR+TMCGTLD
Sbjct: 179 TIMEELADALMYCHGKKVIHRDIKPENLLLGLKGELKIADFGWSVHAPSLRRKTMCGTLD 238
Query: 627 YLPPEMVESVEH 662
YLPPEM+E H
Sbjct: 239 YLPPEMIEGRMH 250
>sp|Q2TA06|STK6_BOVIN Serine/threonine-protein kinase 6 OS=Bos taurus GN=AURKA
PE=2 SV=1
Length = 402
Score = 270 bits (688), Expect = 2e-071
Identities = 129/182 (70%), Positives = 152/182 (83%), Gaps = 1/182 (0%)
Frame = +3
Query: 120 QKRWNLNDFDIGKPLGRGKFGHVYLAREKRSNHIVALKVLFKTQLQQSQVEHQLRREVEI 299
+++W L DF+IG+PLG+GKFG+VYLAREK+S I+ALKVLFK QL+++ VEHQLRREVEI
Sbjct: 125 KRQWALEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRREVEI 184
Query: 300 QSHLRNPNILRLYGYFYDQERVYLILEYAARGELYKELQKCKYFSERRAATYVASLARAL 479
QSHLR+PNILRLYGYF+D RVYLILEYA G +Y+ELQK F E+R ATY+ LA AL
Sbjct: 185 QSHLRHPNILRLYGYFHDATRVYLILEYAPLGAVYRELQKLSKFDEQRTATYITELANAL 244
Query: 480 IYCHGKHVIHRDIKPENLLIGAQGELKIADFGWSVHT-FNRRRTMCGTLDYLPPEMVESV 656
YCH K VIHRDIKPENLL+G+ GELKIADFGWSVH +RR T+CGTLDYLPPEM+E
Sbjct: 245 SYCHSKRVIHRDIKPENLLLGSAGELKIADFGWSVHAPSSRRTTLCGTLDYLPPEMIEGR 304
Query: 657 EH 662
H
Sbjct: 305 MH 306
>sp|O14965|STK6_HUMAN Serine/threonine-protein kinase 6 OS=Homo sapiens GN=AURKA
PE=1 SV=2
Length = 403
Score = 270 bits (688), Expect = 2e-071
Identities = 129/182 (70%), Positives = 152/182 (83%), Gaps = 1/182 (0%)
Frame = +3
Query: 120 QKRWNLNDFDIGKPLGRGKFGHVYLAREKRSNHIVALKVLFKTQLQQSQVEHQLRREVEI 299
+++W L DF+IG+PLG+GKFG+VYLAREK+S I+ALKVLFK QL+++ VEHQLRREVEI
Sbjct: 125 KRQWALEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRREVEI 184
Query: 300 QSHLRNPNILRLYGYFYDQERVYLILEYAARGELYKELQKCKYFSERRAATYVASLARAL 479
QSHLR+PNILRLYGYF+D RVYLILEYA G +Y+ELQK F E+R ATY+ LA AL
Sbjct: 185 QSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITELANAL 244
Query: 480 IYCHGKHVIHRDIKPENLLIGAQGELKIADFGWSVHT-FNRRRTMCGTLDYLPPEMVESV 656
YCH K VIHRDIKPENLL+G+ GELKIADFGWSVH +RR T+CGTLDYLPPEM+E
Sbjct: 245 SYCHSKRVIHRDIKPENLLLGSAGELKIADFGWSVHAPSSRRTTLCGTLDYLPPEMIEGR 304
Query: 657 EH 662
H
Sbjct: 305 MH 306
>sp|O70126|AURKB_MOUSE Serine/threonine-protein kinase 12 OS=Mus musculus
GN=Aurkb PE=1 SV=1
Length = 345
Score = 268 bits (685), Expect = 4e-071
Identities = 132/211 (62%), Positives = 169/211 (80%), Gaps = 4/211 (1%)
Frame = +3
Query: 42 SSARSLSLSSMAIASEK-EASDVSAVAQKR--WNLNDFDIGKPLGRGKFGHVYLAREKRS 212
S+++S + +A K + S S +Q + + +++F+IG+PLG+GKFG+VYLAREK+S
Sbjct: 45 SNSQSTAAPGQKLAENKSQGSTASQGSQNKQPFTIDNFEIGRPLGKGKFGNVYLAREKKS 104
Query: 213 NHIVALKVLFKTQLQQSQVEHQLRREVEIQSHLRNPNILRLYGYFYDQERVYLILEYAAR 392
IVALK+LFK+Q+++ VEHQLRRE+EIQ+HL++PNIL+LY YFYDQ+R+YLILEYA R
Sbjct: 105 RFIVALKILFKSQIEKEGVEHQLRREIEIQAHLKHPNILQLYNYFYDQQRIYLILEYAPR 164
Query: 393 GELYKELQKCKYFSERRAATYVASLARALIYCHGKHVIHRDIKPENLLIGAQGELKIADF 572
GELYKELQK + F E+R AT + L+ AL YCH K VIHRDIKPENLL+G QGELKIADF
Sbjct: 165 GELYKELQKSRTFDEQRTATIMEELSDALTYCHKKKVIHRDIKPENLLLGLQGELKIADF 224
Query: 573 GWSVHTFN-RRRTMCGTLDYLPPEMVESVEH 662
GWSVH + RR+TMCGTLDYLPPEM+E H
Sbjct: 225 GWSVHAPSLRRKTMCGTLDYLPPEMIEGRMH 255
>sp|O55099|AURKB_RAT Serine/threonine-protein kinase 12 OS=Rattus norvegicus
GN=Aurkb PE=1 SV=1
Length = 343
Score = 268 bits (683), Expect = 7e-071
Identities = 129/209 (61%), Positives = 170/209 (81%), Gaps = 2/209 (0%)
Frame = +3
Query: 42 SSARSLSLSSMAIASEKEASDV-SAVAQKRWNLNDFDIGKPLGRGKFGHVYLAREKRSNH 218
S+++S ++ + K A+ + + +++ + +++F+IG+PLG+GKFG+VYLAREK+S
Sbjct: 45 SNSQSTAVPGQKLTENKGATALQGSQSRQPFTIDNFEIGRPLGKGKFGNVYLAREKKSRF 104
Query: 219 IVALKVLFKTQLQQSQVEHQLRREVEIQSHLRNPNILRLYGYFYDQERVYLILEYAARGE 398
IVALK+LFK+Q+++ VEHQLRRE+EIQ+HL++PNIL+LY YFYDQ+R+YLILEYA RGE
Sbjct: 105 IVALKILFKSQIEKEGVEHQLRREIEIQAHLKHPNILQLYNYFYDQQRIYLILEYAPRGE 164
Query: 399 LYKELQKCKYFSERRAATYVASLARALIYCHGKHVIHRDIKPENLLIGAQGELKIADFGW 578
LYKELQK F E+R AT + L+ AL+YCH K VIHRDIKPENLL+G QGELKIADFGW
Sbjct: 165 LYKELQKSGTFDEQRTATIMEELSDALMYCHKKKVIHRDIKPENLLLGLQGELKIADFGW 224
Query: 579 SVHTFN-RRRTMCGTLDYLPPEMVESVEH 662
SVH + RR+TMCGTLDYLPPEM+E H
Sbjct: 225 SVHAPSLRRKTMCGTLDYLPPEMIEGRMH 253
>sp|Q6DE08|AUKBA_XENLA Serine/threonine-protein kinase 12-A OS=Xenopus laevis
GN=aurkb-a PE=1 SV=1
Length = 361
Score = 267 bits (681), Expect = 1e-070
Identities = 130/209 (62%), Positives = 172/209 (82%), Gaps = 3/209 (1%)
Frame = +3
Query: 45 SARSLSLSSMAIASEKEASD--VSAVAQKRWNLNDFDIGKPLGRGKFGHVYLAREKRSNH 218
SA S +A+++E + + ++ + ++++ ++DFDIG+PLG+GKFG+VYLAREK++
Sbjct: 58 SASSSVPGRVAVSTEMPSQNTALAEMPKRKFTIDDFDIGRPLGKGKFGNVYLAREKQNKF 117
Query: 219 IVALKVLFKTQLQQSQVEHQLRREVEIQSHLRNPNILRLYGYFYDQERVYLILEYAARGE 398
I+ALKVLFK+QL++ VEHQLRRE+EIQSHLR+PNILR+Y YF+D++R+YL+LE+A RGE
Sbjct: 118 IMALKVLFKSQLEKEGVEHQLRREIEIQSHLRHPNILRMYNYFHDRKRIYLMLEFAPRGE 177
Query: 399 LYKELQKCKYFSERRAATYVASLARALIYCHGKHVIHRDIKPENLLIGAQGELKIADFGW 578
LYKELQK F E+R+AT++ LA AL YCH + VIHRDIKPENLL+G +GELKIADFGW
Sbjct: 178 LYKELQKHGRFDEQRSATFMEELADALHYCHERKVIHRDIKPENLLMGYKGELKIADFGW 237
Query: 579 SVHTFN-RRRTMCGTLDYLPPEMVESVEH 662
SVH + RRRTMCGTLDYLPPEM+E H
Sbjct: 238 SVHAPSLRRRTMCGTLDYLPPEMIEGKTH 266
>sp|Q6GPL3|AUKBB_XENLA Serine/threonine-protein kinase 12-B OS=Xenopus laevis
GN=aurkb-b PE=2 SV=1
Length = 368
Score = 266 bits (679), Expect = 2e-070
Identities = 132/212 (62%), Positives = 170/212 (80%), Gaps = 4/212 (1%)
Frame = +3
Query: 39 LSSARSLSLSSMAIASEKEASDVSAVAQ---KRWNLNDFDIGKPLGRGKFGHVYLAREKR 209
++ A S S+ AS +A+A+ +++ ++DFDIG+PLG+GKFG+VYLAREK+
Sbjct: 62 VTPAASSSVPGRVALGTDVASHNTALAEAPKRKFTIDDFDIGRPLGKGKFGNVYLAREKQ 121
Query: 210 SNHIVALKVLFKTQLQQSQVEHQLRREVEIQSHLRNPNILRLYGYFYDQERVYLILEYAA 389
+ I+ALKVLFK+QL++ VEHQLRRE+EIQSHLR+PNILR+Y YF+D++R+YL+LE+A
Sbjct: 122 NKFIMALKVLFKSQLEKEGVEHQLRREIEIQSHLRHPNILRMYNYFHDRKRIYLMLEFAP 181
Query: 390 RGELYKELQKCKYFSERRAATYVASLARALIYCHGKHVIHRDIKPENLLIGAQGELKIAD 569
RGELYKELQK F E+R+AT++ LA AL YCH + VIHRDIKPENLL+G +GELKIAD
Sbjct: 182 RGELYKELQKHGRFDEQRSATFMEELADALQYCHERKVIHRDIKPENLLMGYKGELKIAD 241
Query: 570 FGWSVHTFN-RRRTMCGTLDYLPPEMVESVEH 662
FGWSVH + RRRTMCGTLDYLPPEM+E H
Sbjct: 242 FGWSVHAPSLRRRTMCGTLDYLPPEMIEGKTH 273
>sp|A4IGM9|AURKB_XENTR Serine/threonine-protein kinase 12 OS=Xenopus tropicalis
GN=aurkb PE=2 SV=1
Length = 360
Score = 265 bits (677), Expect = 4e-070
Identities = 130/212 (61%), Positives = 171/212 (80%), Gaps = 4/212 (1%)
Frame = +3
Query: 39 LSSARSLSLSSMAIASEKEASDVSAVAQ---KRWNLNDFDIGKPLGRGKFGHVYLAREKR 209
++ + S S+ S +S +A+A+ +++ ++DFDIG+PLG+GKFG+VYLAR+K+
Sbjct: 55 ITPSASSSVPGRVAVSMDASSQNTALAELPKRKFTIDDFDIGRPLGKGKFGNVYLARDKQ 114
Query: 210 SNHIVALKVLFKTQLQQSQVEHQLRREVEIQSHLRNPNILRLYGYFYDQERVYLILEYAA 389
+ I+ALKVLFK+QL++ VEHQLRRE+EIQSHLR+PNILR+Y YF+D++R+YL+LE+A
Sbjct: 115 NKFIMALKVLFKSQLEKEGVEHQLRREIEIQSHLRHPNILRMYNYFHDRKRIYLMLEFAP 174
Query: 390 RGELYKELQKCKYFSERRAATYVASLARALIYCHGKHVIHRDIKPENLLIGAQGELKIAD 569
RGELYKELQK F E+R+AT++ LA AL YCH + VIHRDIKPENLL+G +GELKIAD
Sbjct: 175 RGELYKELQKHGRFDEQRSATFMEELADALQYCHERKVIHRDIKPENLLMGYKGELKIAD 234
Query: 570 FGWSVHTFN-RRRTMCGTLDYLPPEMVESVEH 662
FGWSVH + RRRTMCGTLDYLPPEM+E H
Sbjct: 235 FGWSVHAPSLRRRTMCGTLDYLPPEMIEGKTH 266
>sp|Q9UQB9|AURKC_HUMAN Serine/threonine-protein kinase 13 OS=Homo sapiens
GN=AURKC PE=2 SV=1
Length = 309
Score = 262 bits (669), Expect = 3e-069
Identities = 127/190 (66%), Positives = 157/190 (82%), Gaps = 1/190 (0%)
Frame = +3
Query: 84 SEKEASDVSAVAQKRWNLNDFDIGKPLGRGKFGHVYLAREKRSNHIVALKVLFKTQLQQS 263
+ + A S+ A +R ++DF+IG+PLG+GKFG+VYLAR K S+ IVALKVLFK+Q+++
Sbjct: 23 ANQTAQQPSSPAMRRLTVDDFEIGRPLGKGKFGNVYLARLKESHFIVALKVLFKSQIEKE 82
Query: 264 QVEHQLRREVEIQSHLRNPNILRLYGYFYDQERVYLILEYAARGELYKELQKCKYFSERR 443
+EHQLRRE+EIQ+HL++PNILRLY YF+D RVYLILEYA RGELYKELQK + E+R
Sbjct: 83 GLEHQLRREIEIQAHLQHPNILRLYNYFHDARRVYLILEYAPRGELYKELQKSEKLDEQR 142
Query: 444 AATYVASLARALIYCHGKHVIHRDIKPENLLIGAQGELKIADFGWSVHTFN-RRRTMCGT 620
AT + LA AL YCH K VIHRDIKPENLL+G +GE+KIADFGWSVHT + RR+TMCGT
Sbjct: 143 TATIIEELADALTYCHDKKVIHRDIKPENLLLGFRGEVKIADFGWSVHTPSLRRKTMCGT 202
Query: 621 LDYLPPEMVE 650
LDYLPPEM+E
Sbjct: 203 LDYLPPEMIE 212
>sp|O64629|AUR3_ARATH Serine/threonine-protein kinase Aurora-3 OS=Arabidopsis
thaliana GN=AUR3 PE=2 SV=1
Length = 288
Score = 258 bits (658), Expect = 6e-068
Identities = 120/193 (62%), Positives = 160/193 (82%)
Frame = +3
Query: 84 SEKEASDVSAVAQKRWNLNDFDIGKPLGRGKFGHVYLAREKRSNHIVALKVLFKTQLQQS 263
S+K + +K+W+L DF+IG+PLG+GKFG VYLARE +S +IVALKV+FK Q+++
Sbjct: 2 SKKSTESDAGNTEKQWSLADFEIGRPLGKGKFGRVYLAREAKSKYIVALKVIFKEQIEKY 61
Query: 264 QVEHQLRREVEIQSHLRNPNILRLYGYFYDQERVYLILEYAARGELYKELQKCKYFSERR 443
++ HQLRRE+EIQ+ LR+PNILRL+G+F+D ER++LILEYA GELY L++ + +E++
Sbjct: 62 KIHHQLRREMEIQTSLRHPNILRLFGWFHDNERIFLILEYAHGGELYGVLKQNGHLTEQQ 121
Query: 444 AATYVASLARALIYCHGKHVIHRDIKPENLLIGAQGELKIADFGWSVHTFNRRRTMCGTL 623
AATY+ASL++AL YCHGK VIHRDIKPENLL+ +G LKIADFGWSV + N+R+TMCGTL
Sbjct: 122 AATYIASLSQALAYCHGKCVIHRDIKPENLLLDHEGRLKIADFGWSVQSSNKRKTMCGTL 181
Query: 624 DYLPPEMVESVEH 662
DYL PEMVE+ +H
Sbjct: 182 DYLAPEMVENRDH 194
Database: UniProt/SwissProt
Posted date: Sat Aug 07 14:36:18 2010
Number of letters in database: 182,829,261
Number of sequences in database: 518,415
Lambda K H
0.267 0.041 0.140
Gapped
Lambda K H
0.267 0.041 0.140
Matrix: blosum62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 185,567,659,578
Number of Sequences: 518415
Number of Extensions: 185567659578
Number of Successful Extensions: 1125298771
Number of sequences better than 0.0: 0
|
