BLASTX 7.6.2
Query= UN49964 /QuerySize=840
(839 letters)
Database: UniProt/SwissProt;
518,415 sequences; 182,829,261 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q54QP6|OSB8_DICDI Oxysterol-binding protein 8 OS=Dictyosteliu... 129 4e-029
sp|Q9BZF3|OSBL6_HUMAN Oxysterol-binding protein-related protein ... 127 1e-028
sp|Q8BXR9|OSBL6_MOUSE Oxysterol-binding protein-related protein ... 127 1e-028
sp|O14340|YB35_SCHPO Oxysterol-binding protein homolog C2F12.05c... 126 2e-028
sp|Q9BZF2|OSBL7_HUMAN Oxysterol-binding protein-related protein ... 124 7e-028
sp|Q9H4L5|OSBL3_HUMAN Oxysterol-binding protein-related protein ... 120 1e-026
sp|Q9DBS9|OSBL3_MOUSE Oxysterol-binding protein-related protein ... 119 2e-026
sp|Q54ID7|OSB11_DICDI Oxysterol-binding protein 11 OS=Dictyostel... 111 6e-024
sp|P35845|OSH1_YEAST Oxysterol-binding protein homolog 1 OS=Sacc... 107 2e-022
sp|Q9H1P3|OSBL2_HUMAN Oxysterol-binding protein-related protein ... 105 6e-022
sp|Q12451|OSH2_YEAST Oxysterol-binding protein homolog 2 OS=Sacc... 103 2e-021
sp|Q5QNQ6|OSBP2_MOUSE Oxysterol-binding protein 2 OS=Mus musculu... 87 2e-016
sp|Q969R2|OSBP2_HUMAN Oxysterol-binding protein 2 OS=Homo sapien... 85 5e-016
sp|Q54PS9|OSB9_DICDI Oxysterol-binding protein 9 OS=Dictyosteliu... 73 2e-012
>sp|Q54QP6|OSB8_DICDI Oxysterol-binding protein 8 OS=Dictyostelium discoideum
GN=osbH PE=1 SV=1
Length = 402
Score = 129 bits (322), Expect = 4e-029
Identities = 66/174 (37%), Positives = 109/174 (62%), Gaps = 4/174 (2%)
Frame = +1
Query: 202 NGLVGY-EGLEVINPEGSTEDAAEEANRGRWKQEERDGYWKMMHKYIGSDVTSMVTLPVI 378
+G + Y +GL N E++ + N+G + E+R G K + Y+G D+TS+++LPV
Sbjct: 3 SGALNYMKGLVGTNENLQVEESGD--NKGDIEPEQRKGLLKQLSSYVGKDITSLISLPVW 60
Query: 379 IFEPMTMLQKMAELMEYSHLLDMADETEDPYMRMVYASSWAISVYFAFQRTWKPFNPILG 558
IFEP++ LQ M+E ++Y+ LL A + + ++ + Y +++ ++Y RT KPFNPILG
Sbjct: 61 IFEPVSFLQVMSEPLQYNALLSKASKQDSEFLCLAYLAAFNCALYSTAVRTRKPFNPILG 120
Query: 559 ETYEMANYNG-VNFISEQVSHHPPMSAGHAENQYFTYDCTSKLKTKFLGNSIDV 717
ET+E+ + G F++EQVSHHPP+ ++ +T + LK+KF GNS +V
Sbjct: 121 ETFEIVDKKGEFRFLAEQVSHHPPIGVSETISEDYTLQLETLLKSKFYGNSSEV 174
>sp|Q9BZF3|OSBL6_HUMAN Oxysterol-binding protein-related protein 6 OS=Homo
sapiens GN=OSBPL6 PE=1 SV=1
Length = 934
Score = 127 bits (317), Expect = 1e-028
Identities = 67/140 (47%), Positives = 92/140 (65%), Gaps = 4/140 (2%)
Frame = +1
Query: 316 WKMMHKYIGSDVTSMVTLPVIIFEPMTMLQKMAELMEYSHLLDMADETEDPYMRMVYASS 495
W ++ IG D+ S V++PV + EP+ LQ + E MEYS LLD A ET+DPY RMV ++
Sbjct: 572 WNILRNNIGKDL-SKVSMPVELNEPLNTLQHLCEEMEYSELLDKASETDDPYERMVLVAA 630
Query: 496 WAISVYFA--FQRTWKPFNPILGETYE-MANYNGVNFISEQVSHHPPMSAGHAENQYFTY 666
+A+S Y + F+ KPFNP+LGETYE + G F SEQVSHHPP+SA H E++ F +
Sbjct: 631 FAVSGYCSTYFRAGSKPFNPVLGETYECIREDKGFRFFSEQVSHHPPISACHCESKNFVF 690
Query: 667 DCTSKLKTKFLGNSIDVYPV 726
+ K KF G S+++ PV
Sbjct: 691 WQDIRWKNKFWGKSMEILPV 710
>sp|Q8BXR9|OSBL6_MOUSE Oxysterol-binding protein-related protein 6 OS=Mus
musculus GN=Osbpl6 PE=2 SV=1
Length = 959
Score = 127 bits (317), Expect = 1e-028
Identities = 67/140 (47%), Positives = 92/140 (65%), Gaps = 4/140 (2%)
Frame = +1
Query: 316 WKMMHKYIGSDVTSMVTLPVIIFEPMTMLQKMAELMEYSHLLDMADETEDPYMRMVYASS 495
W ++ IG D+ S V++PV + EP+ LQ + E MEYS LLD A ET+DPY RMV ++
Sbjct: 597 WNILRNNIGKDL-SKVSMPVELNEPLNTLQHLCEEMEYSELLDKASETDDPYERMVLVAA 655
Query: 496 WAISVYFA--FQRTWKPFNPILGETYE-MANYNGVNFISEQVSHHPPMSAGHAENQYFTY 666
+A+S Y + F+ KPFNP+LGETYE + G F SEQVSHHPP+SA H E++ F +
Sbjct: 656 FAVSGYCSTYFRAGSKPFNPVLGETYECIREDKGFRFFSEQVSHHPPISACHCESKNFVF 715
Query: 667 DCTSKLKTKFLGNSIDVYPV 726
+ K KF G S+++ PV
Sbjct: 716 WQDIRWKNKFWGKSMEILPV 735
>sp|O14340|YB35_SCHPO Oxysterol-binding protein homolog C2F12.05c
OS=Schizosaccharomyces pombe GN=SPBC2F12.05c PE=1 SV=2
Length = 1310
Score = 126 bits (315), Expect = 2e-028
Identities = 65/139 (46%), Positives = 91/139 (65%), Gaps = 3/139 (2%)
Frame = +1
Query: 316 WKMMHKYIGSDVTSMVTLPVIIFEPMTMLQKMAELMEYSHLLDMADETEDPYMRMVYASS 495
W ++ IG D+T M TLPV EP ++LQ++AE MEY+ LLD A +DPY R++Y ++
Sbjct: 939 WGILKGMIGKDMTKM-TLPVSFNEPTSLLQRVAEDMEYTELLDQASHNKDPYQRILYVAA 997
Query: 496 WAISVYFA-FQRTWKPFNPILGETYEMAN-YNGVNFISEQVSHHPPMSAGHAENQYFTYD 669
+A S Y + R KPFNP+LGETYE + G FI EQVSHHPP+ A ++E+ + Y
Sbjct: 998 FAASEYASTLNRVAKPFNPLLGETYEFCHPQRGFRFIVEQVSHHPPVGAAYSESANWKYY 1057
Query: 670 CTSKLKTKFLGNSIDVYPV 726
S +K+KF G S D+ P+
Sbjct: 1058 GESSVKSKFYGKSFDISPL 1076
>sp|Q9BZF2|OSBL7_HUMAN Oxysterol-binding protein-related protein 7 OS=Homo
sapiens GN=OSBPL7 PE=2 SV=1
Length = 842
Score = 124 bits (311), Expect = 7e-028
Identities = 66/140 (47%), Positives = 91/140 (65%), Gaps = 4/140 (2%)
Frame = +1
Query: 316 WKMMHKYIGSDVTSMVTLPVIIFEPMTMLQKMAELMEYSHLLDMADETEDPYMRMVYASS 495
W ++ IG D+ S V++PV + EP+ LQ++ E +EYS LLD A DP RMVY ++
Sbjct: 480 WNILRNNIGKDL-SKVSMPVQLNEPLNTLQRLCEELEYSSLLDQASRIADPCERMVYIAA 538
Query: 496 WAISVYFA--FQRTWKPFNPILGETYEMANYN-GVNFISEQVSHHPPMSAGHAENQYFTY 666
+A+S Y + + KPFNP+LGETYE + G FISEQVSHHPP+SA HAE++ F +
Sbjct: 539 FAVSAYSSTYHRAGCKPFNPVLGETYECERPDRGFRFISEQVSHHPPISACHAESENFAF 598
Query: 667 DCTSKLKTKFLGNSIDVYPV 726
K K KF G S+++ PV
Sbjct: 599 WQDMKWKNKFWGKSLEIVPV 618
>sp|Q9H4L5|OSBL3_HUMAN Oxysterol-binding protein-related protein 3 OS=Homo
sapiens GN=OSBPL3 PE=1 SV=1
Length = 887
Score = 120 bits (300), Expect = 1e-026
Identities = 63/140 (45%), Positives = 90/140 (64%), Gaps = 4/140 (2%)
Frame = +1
Query: 316 WKMMHKYIGSDVTSMVTLPVIIFEPMTMLQKMAELMEYSHLLDMADETEDPYMRMVYASS 495
W ++ IG D+ S V +PV + EP+ LQ++ E +EYS LLD A + P RMVY ++
Sbjct: 529 WNILRNNIGKDL-SKVAMPVELNEPLNTLQRLCEELEYSELLDKAAQIPSPLERMVYVAA 587
Query: 496 WAISVYFA--FQRTWKPFNPILGETYE-MANYNGVNFISEQVSHHPPMSAGHAENQYFTY 666
+AIS Y + ++ KPFNP+LGETYE + G F SEQVSHHPP+SA HAE++ F +
Sbjct: 588 FAISAYASSYYRAGSKPFNPVLGETYECIREDKGFQFFSEQVSHHPPISACHAESRNFVF 647
Query: 667 DCTSKLKTKFLGNSIDVYPV 726
+ K KF G S+++ P+
Sbjct: 648 WQDVRWKNKFWGKSMEIVPI 667
>sp|Q9DBS9|OSBL3_MOUSE Oxysterol-binding protein-related protein 3 OS=Mus
musculus GN=Osbpl3 PE=1 SV=1
Length = 855
Score = 119 bits (298), Expect = 2e-026
Identities = 63/140 (45%), Positives = 88/140 (62%), Gaps = 4/140 (2%)
Frame = +1
Query: 316 WKMMHKYIGSDVTSMVTLPVIIFEPMTMLQKMAELMEYSHLLDMADETEDPYMRMVYASS 495
W ++ IG D+ S V +PV + EP+ LQ++ E +EYS LLD A P RMVY ++
Sbjct: 497 WSILRNNIGKDL-SKVAMPVELNEPLNTLQRLCEELEYSELLDKASRIPSPLERMVYVAA 555
Query: 496 WAISVYFA--FQRTWKPFNPILGETYEMANYN-GVNFISEQVSHHPPMSAGHAENQYFTY 666
+AIS Y + F+ KPFNP+LGETYE + G F +EQVSHHPP+SA HAE+ F +
Sbjct: 556 FAISAYASSYFRAGSKPFNPVLGETYECIRQDKGFQFFAEQVSHHPPISACHAESGNFVF 615
Query: 667 DCTSKLKTKFLGNSIDVYPV 726
+ K KF G S+++ P+
Sbjct: 616 WQDVRWKNKFWGKSMEIVPI 635
>sp|Q54ID7|OSB11_DICDI Oxysterol-binding protein 11 OS=Dictyostelium discoideum
GN=osbK PE=3 SV=1
Length = 571
Score = 111 bits (277), Expect = 6e-024
Identities = 54/142 (38%), Positives = 85/142 (59%), Gaps = 1/142 (0%)
Frame = +1
Query: 298 EERDGYWKMMHKYIGSDVTSMVTLPVIIFEPMTMLQKMAELMEYSHLLDMADETEDPYMR 477
E++ WK + +G D S+V+LPV FEP+T+L+ E + + L++ A D R
Sbjct: 88 EDKKSLWKKVGGLVGKDPMSLVSLPVYFFEPLTVLECQLEPLRFVELIEKASTCSDSIDR 147
Query: 478 MVYASSWAISVYFAFQRTWKPFNPILGETYEMANYNG-VNFISEQVSHHPPMSAGHAENQ 654
++Y +++ I+V+ ++ RT KPFNP+LGET+E + G EQVSHHPP+ ++
Sbjct: 148 LMYLTAFNIAVFSSYTRTAKPFNPLLGETFEYIDKQGRYKSFCEQVSHHPPIGIAQTTSE 207
Query: 655 YFTYDCTSKLKTKFLGNSIDVY 720
F S + TKF GNS+DV+
Sbjct: 208 IFDLQQESWITTKFWGNSLDVF 229
>sp|P35845|OSH1_YEAST Oxysterol-binding protein homolog 1 OS=Saccharomyces
cerevisiae GN=OSH1 PE=1 SV=4
Length = 1188
Score = 107 bits (265), Expect = 2e-022
Identities = 61/157 (38%), Positives = 94/157 (59%), Gaps = 9/157 (5%)
Frame = +1
Query: 253 TEDAAEEANRGRWKQEERDGYWKMMHKYIGSDVTSMVTLPVIIFEPMTMLQKMAELMEYS 432
T+ A +E NR + G W ++ +G D+T + TLPV EP ++LQ+++E +EYS
Sbjct: 786 TKLALDEDNR------PKIGLWSVLKSMVGQDLTKL-TLPVSFNEPTSLLQRVSEDIEYS 838
Query: 433 HLLDMADETEDPYMRMVYASSWAISVYFA-FQRTWKPFNPILGETYEMANYNG-VNFISE 606
H+LD A ED +RM+Y +++ S+Y + R KPFNP+LGET+E A +G F +E
Sbjct: 839 HILDQAATFEDSSLRMLYVAAFTASMYASTTNRVSKPFNPLLGETFEYARTDGQYRFFTE 898
Query: 607 QVSHHPPMSAGHAENQYFTYDCTSKLKTKFLGNSIDV 717
QVSHHPP+SA E+ + + + + F G + V
Sbjct: 899 QVSHHPPISATWTESPKWDFYGECNVDSSFNGRTFAV 935
>sp|Q9H1P3|OSBL2_HUMAN Oxysterol-binding protein-related protein 2 OS=Homo
sapiens GN=OSBPL2 PE=1 SV=1
Length = 480
Score = 105 bits (260), Expect = 6e-022
Identities = 58/140 (41%), Positives = 88/140 (62%), Gaps = 5/140 (3%)
Frame = +1
Query: 316 WKMMHKYIGSDVTSMVTLPVIIFEPMTMLQKMAELMEYSHLLDMADETEDPYMRMVYASS 495
W ++ K +G ++ S +T+P+ EP++ LQ++ E ME+ +L+ A P RM ++
Sbjct: 77 WTILKKCVGLEL-SKITMPIAFNEPLSFLQRITEYMEHVYLIHRASCQPQPLERMQSVAA 135
Query: 496 WAIS-VYFAFQRTWKPFNPILGETYEMANYN-GVNFISEQVSHHPPMSAGHAE--NQYFT 663
+A+S V ++RT KPFNP+LGETYE+ + G FISEQVSHHPP+SA H+E N F
Sbjct: 136 FAVSAVASQWERTGKPFNPLLGETYELIREDLGFRFISEQVSHHPPISAFHSEGLNHDFL 195
Query: 664 YDCTSKLKTKFLGNSIDVYP 723
+ + K KF G S++ P
Sbjct: 196 FHGSIYPKLKFWGKSVEAEP 215
>sp|Q12451|OSH2_YEAST Oxysterol-binding protein homolog 2 OS=Saccharomyces
cerevisiae GN=OSH2 PE=1 SV=1
Length = 1283
Score = 103 bits (255), Expect = 2e-021
Identities = 62/156 (39%), Positives = 92/156 (58%), Gaps = 7/156 (4%)
Frame = +1
Query: 268 EEANRGRWKQEERD----GYWKMMHKYIGSDVTSMVTLPVIIFEPMTMLQKMAELMEYSH 435
E+ R R ++ D W ++ +G D+T M TLPV EP ++LQ++AE +EYS
Sbjct: 879 EDGIRKRLSMDKDDRPKISLWAVLKSMVGKDMTRM-TLPVTFNEPTSLLQRVAEDLEYSE 937
Query: 436 LLDMADETEDPYMRMVYASSWAISVYFA-FQRTWKPFNPILGETYEMANYN-GVNFISEQ 609
LLD A ED +R +Y +++ S Y + +R KPFNP+LGET+E + + F +EQ
Sbjct: 938 LLDQAATFEDSTLRTLYVAAFTASSYASTTKRVAKPFNPLLGETFEYSRPDKQYRFFTEQ 997
Query: 610 VSHHPPMSAGHAENQYFTYDCTSKLKTKFLGNSIDV 717
VSHHPP+SA E+ + + S + TKF G S +V
Sbjct: 998 VSHHPPISATWTESPRWDFWGESFVDTKFNGRSFNV 1033
>sp|Q5QNQ6|OSBP2_MOUSE Oxysterol-binding protein 2 OS=Mus musculus GN=Osbp2 PE=2
SV=1
Length = 908
Score = 87 bits (213), Expect = 2e-016
Identities = 50/141 (35%), Positives = 81/141 (57%), Gaps = 5/141 (3%)
Frame = +1
Query: 316 WKMMHKYIGSDVTSMVTLPVIIFEPMTMLQKMAELMEYSHLLDMADETEDPYMRMVYASS 495
W +M IG ++ S + +PV EP++MLQ++ E +EY HLLD A +M ++
Sbjct: 521 WSIMKNCIGREL-SRIPMPVNFNEPLSMLQRLTEDLEYHHLLDKAVNCTSSVEQMCLVAA 579
Query: 496 WAISVY-FAFQRTWKPFNPILGETYEMANYN--GVNFISEQVSHHPPMSAGHAENQY-FT 663
+++S Y R KPFNP+LGET+E+ G+ + EQVSHHPP +A H +++ ++
Sbjct: 580 FSVSSYSTTVHRIAKPFNPMLGETFELDRMEDMGLRSLCEQVSHHPPSAAHHVFSKHGWS 639
Query: 664 YDCTSKLKTKFLGNSIDVYPV 726
+ +KF G I + P+
Sbjct: 640 LWQEITIASKFRGKYISIMPL 660
>sp|Q969R2|OSBP2_HUMAN Oxysterol-binding protein 2 OS=Homo sapiens GN=OSBP2 PE=1
SV=2
Length = 916
Score = 85 bits (209), Expect = 5e-016
Identities = 49/141 (34%), Positives = 82/141 (58%), Gaps = 5/141 (3%)
Frame = +1
Query: 316 WKMMHKYIGSDVTSMVTLPVIIFEPMTMLQKMAELMEYSHLLDMADETEDPYMRMVYASS 495
W +M IG ++ S + +PV EP++MLQ++ E +EY HLLD A +M ++
Sbjct: 524 WSIMKNCIGREL-SRIPMPVNFNEPLSMLQRLTEDLEYHHLLDKAVHCTSSVEQMCLVAA 582
Query: 496 WAISVY-FAFQRTWKPFNPILGETYEMANYN--GVNFISEQVSHHPPMSAGHAENQY-FT 663
+++S Y R KPFNP+LGET+E+ + G+ + EQVSHHPP +A + +++ ++
Sbjct: 583 FSVSSYSTTVHRIAKPFNPMLGETFELDRLDDMGLRSLCEQVSHHPPSAAHYVFSKHGWS 642
Query: 664 YDCTSKLKTKFLGNSIDVYPV 726
+ +KF G I + P+
Sbjct: 643 LWQEITISSKFRGKYISIMPL 663
>sp|Q54PS9|OSB9_DICDI Oxysterol-binding protein 9 OS=Dictyostelium discoideum
GN=osbI PE=3 SV=1
Length = 428
Score = 73 bits (177), Expect = 2e-012
Identities = 40/100 (40%), Positives = 59/100 (59%), Gaps = 2/100 (2%)
Frame = +1
Query: 340 GSDVTSMVTLPVIIFEPMTMLQKMAELMEYSHL-LDMADETEDPYMRMVYASSWAISVYF 516
G ++TS LP+ +FE + L+K+ + M + L L A ET DP RM +S+ +S
Sbjct: 102 GKELTS-TCLPIELFEARSFLEKVTDTMAFGPLYLKAAAETNDPIERMKMVASFVVSGLH 160
Query: 517 AFQRTWKPFNPILGETYEMANYNGVNFISEQVSHHPPMSA 636
KPFNP+LGET+E +G + EQ+SHHPP+S+
Sbjct: 161 LTTTIAKPFNPLLGETFECDLADGSSAFCEQISHHPPISS 200
Database: UniProt/SwissProt
Posted date: Sat Aug 07 14:36:18 2010
Number of letters in database: 182,829,261
Number of sequences in database: 518,415
Lambda K H
0.267 0.041 0.140
Gapped
Lambda K H
0.267 0.041 0.140
Matrix: blosum62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 185,567,659,578
Number of Sequences: 518415
Number of Extensions: 185567659578
Number of Successful Extensions: 1125298771
Number of sequences better than 0.0: 0
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