BLASTX 7.6.2
Query= UN50103 /QuerySize=1246
(1245 letters)
Database: UniProt/SwissProt;
518,415 sequences; 182,829,261 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P54873|HMCS_ARATH Hydroxymethylglutaryl-CoA synthase OS=Arabi... 557 6e-158
sp|P54872|HMCSA_DICDI Hydroxymethylglutaryl-CoA synthase A OS=Di... 366 2e-100
sp|Q5R7Z9|HMCS1_PONAB Hydroxymethylglutaryl-CoA synthase, cytopl... 350 1e-095
sp|Q01581|HMCS1_HUMAN Hydroxymethylglutaryl-CoA synthase, cytopl... 350 2e-095
sp|P23228|HMCS1_CHICK Hydroxymethylglutaryl-CoA synthase, cytopl... 344 1e-093
sp|Q8JZK9|HMCS1_MOUSE Hydroxymethylglutaryl-CoA synthase, cytopl... 342 3e-093
sp|P17425|HMCS1_RAT Hydroxymethylglutaryl-CoA synthase, cytoplas... 341 7e-093
sp|P13704|HMCS1_CRIGR Hydroxymethylglutaryl-CoA synthase, cytopl... 336 3e-091
sp|Q86HL5|HMCSB_DICDI Hydroxymethylglutaryl-CoA synthase B OS=Di... 334 1e-090
sp|P54868|HMCS2_HUMAN Hydroxymethylglutaryl-CoA synthase, mitoch... 332 4e-090
sp|P54961|HMCS1_BLAGE Hydroxymethylglutaryl-CoA synthase 1 OS=Bl... 331 7e-090
sp|P54869|HMCS2_MOUSE Hydroxymethylglutaryl-CoA synthase, mitoch... 330 1e-089
sp|Q2KIE6|HMCS2_BOVIN Hydroxymethylglutaryl-CoA synthase, mitoch... 329 3e-089
sp|P22791|HMCS2_RAT Hydroxymethylglutaryl-CoA synthase, mitochon... 327 1e-088
sp|P54870|HMCS2_BLAGE Hydroxymethylglutaryl-CoA synthase 2 OS=Bl... 318 8e-086
sp|O02734|HMCS2_PIG Hydroxymethylglutaryl-CoA synthase, mitochon... 318 8e-086
sp|P54839|HMCS_YEAST Hydroxymethylglutaryl-CoA synthase OS=Sacch... 305 7e-082
sp|P54874|HMCS_SCHPO Hydroxymethylglutaryl-CoA synthase OS=Schiz... 292 3e-078
sp|P54871|HMCS_CAEEL Hydroxymethylglutaryl-CoA synthase OS=Caeno... 232 4e-060
>sp|P54873|HMCS_ARATH Hydroxymethylglutaryl-CoA synthase OS=Arabidopsis thaliana
GN=HMGS PE=2 SV=2
Length = 461
Score = 557 bits (1435), Expect = 6e-158
Identities = 271/279 (97%), Positives = 275/279 (98%)
Frame = -2
Query: 1121 MAENVGILAMDIYFPPTCVQQEALEAHDGASKGKYTIGLGQDCLAFCTELEDVISMSFNA 942
MA+NVGILAMDIYFPPTCVQQEALEAHDGASKGKYTIGLGQDCLAFCTELEDVISMSFNA
Sbjct: 1 MAKNVGILAMDIYFPPTCVQQEALEAHDGASKGKYTIGLGQDCLAFCTELEDVISMSFNA 60
Query: 941 VTSLLEKYKIDPKQIGRLEVGSETVIDKSKSIKTFLMQLFEKCGNTDVEGVDSTNACYGG 762
VTSL EKYKIDP QIGRLEVGSETVIDKSKSIKTFLMQLFEKCGNTDVEGVDSTNACYGG
Sbjct: 61 VTSLFEKYKIDPNQIGRLEVGSETVIDKSKSIKTFLMQLFEKCGNTDVEGVDSTNACYGG 120
Query: 761 TAALLNCVNWVESNSWDGRYGLVICTDSAVYAEGPARPTGGAAAIAMLIGPNAPIVFESK 582
TAALLNCVNWVESNSWDGRYGLVICTDSAVYAEGPARPTGGAAAIAMLIGP+APIVFESK
Sbjct: 121 TAALLNCVNWVESNSWDGRYGLVICTDSAVYAEGPARPTGGAAAIAMLIGPDAPIVFESK 180
Query: 581 LRGSHMAHVYDFYKPNLASEYPVVDGKLSQTCYLMALDSCYKHLCNKFEKLEGKEFSIND 402
LR SHMAHVYDFYKPNLASEYPVVDGKLSQTCYLMALDSCYKHLCNKFEK+EGKEFSIND
Sbjct: 181 LRASHMAHVYDFYKPNLASEYPVVDGKLSQTCYLMALDSCYKHLCNKFEKIEGKEFSIND 240
Query: 401 ADYFVFHSPYNKLVQKSFARLLYNDFLKNASSIDEAAKE 285
ADY VFHSPYNKLVQKSFARLLYNDFL+NASSIDEAAKE
Sbjct: 241 ADYIVFHSPYNKLVQKSFARLLYNDFLRNASSIDEAAKE 279
Score = 83 bits (203), Expect = 4e-015
Identities = 37/39 (94%), Positives = 39/39 (100%)
Frame = -2
Query: 290 KEGIIDLLAPGTYYLKEVDSLYRRFYGKKGDDGSIANGH 174
KEGIIDLLAPGTYYLKEVDSLYRRFYGKKG+DGS+ANGH
Sbjct: 423 KEGIIDLLAPGTYYLKEVDSLYRRFYGKKGEDGSVANGH 461
>sp|P54872|HMCSA_DICDI Hydroxymethylglutaryl-CoA synthase A OS=Dictyostelium
discoideum GN=hgsA PE=1 SV=2
Length = 482
Score = 366 bits (938), Expect = 2e-100
Identities = 172/292 (58%), Positives = 217/292 (74%)
Frame = -2
Query: 1124 TMAENVGILAMDIYFPPTCVQQEALEAHDGASKGKYTIGLGQDCLAFCTELEDVISMSFN 945
T EN+GI +++YFP T V QE LE DG S+GKYT+GLGQ +AFC + ED+ S+S N
Sbjct: 2 TKPENIGIHGIEVYFPSTYVAQEDLEKFDGVSQGKYTLGLGQTNMAFCGDREDIYSLSLN 61
Query: 944 AVTSLLEKYKIDPKQIGRLEVGSETVIDKSKSIKTFLMQLFEKCGNTDVEGVDSTNACYG 765
AV +L++K+ +DP IGRLEVG+ETVIDKSKS+KT LM LF K GNT ++G+D+ NACYG
Sbjct: 62 AVNNLMDKFNVDPNSIGRLEVGTETVIDKSKSVKTVLMDLFAKHGNTSIDGIDTINACYG 121
Query: 764 GTAALLNCVNWVESNSWDGRYGLVICTDSAVYAEGPARPTGGAAAIAMLIGPNAPIVFES 585
GT+AL N + W+ES+ WDGR +V+ D AVY +GPARPTGGA +AMLIGPNAPI FES
Sbjct: 122 GTSALHNALQWMESSYWDGRNAIVVAGDIAVYEKGPARPTGGAGVVAMLIGPNAPITFES 181
Query: 584 KLRGSHMAHVYDFYKPNLASEYPVVDGKLSQTCYLMALDSCYKHLCNKFEKLEGKEFSIN 405
LRG HM +VYDFYKP++ SEYP VDGKLS +CY A+D+CY FEK GK FS++
Sbjct: 182 GLRGVHMENVYDFYKPDMDSEYPRVDGKLSISCYFRAIDNCYNRYAKAFEKKYGKSFSLD 241
Query: 404 DADYFVFHSPYNKLVQKSFARLLYNDFLKNASSIDEAAKEGIIDLLAPGTYY 249
D+ +FHSPYNKLVQKSF R+LYNDFL N + A+ E ++ TY+
Sbjct: 242 QVDFALFHSPYNKLVQKSFGRMLYNDFLNNPNDSRYASLEAYKNVKPEDTYF 293
>sp|Q5R7Z9|HMCS1_PONAB Hydroxymethylglutaryl-CoA synthase, cytoplasmic OS=Pongo
abelii GN=HMGCS1 PE=2 SV=1
Length = 520
Score = 350 bits (897), Expect = 1e-095
Identities = 170/307 (55%), Positives = 222/307 (72%), Gaps = 8/307 (2%)
Frame = -2
Query: 1115 ENVGILAMDIYFPPTCVQQEALEAHDGASKGKYTIGLGQDCLAFCTELEDVISMSFNAVT 936
++VGI+A++IYFP V Q LE +DG + GKYTIGLGQ + FCT+ ED+ S+ V
Sbjct: 15 KDVGIVALEIYFPSQYVDQAELEKYDGVAAGKYTIGLGQAKMGFCTDREDINSLCMTVVQ 74
Query: 935 SLLEKYKIDPKQIGRLEVGSETVIDKSKSIKTFLMQLFEKCGNTDVEGVDSTNACYGGTA 756
+L+E+ + IGRLEVG+ET+IDKSKS+KT LMQLFE+ GNTD+EG+D+TNACYGGTA
Sbjct: 75 NLMERNNLSYDCIGRLEVGTETIIDKSKSVKTNLMQLFEESGNTDIEGIDTTNACYGGTA 134
Query: 755 ALLNCVNWVESNSWDGRYGLVICTDSAVYAEGPARPTGGAAAIAMLIGPNAPIVFESKLR 576
A+ N VNW+ES+SWDGRY LV+ D AVYA G ARPTGG A+A+LIGPNAP++FE LR
Sbjct: 135 AVFNAVNWIESSSWDGRYALVVAGDIAVYATGNARPTGGVGAVALLIGPNAPLIFERGLR 194
Query: 575 GSHMAHVYDFYKPNLASEYPVVDGKLSQTCYLMALDSCYKHLCNKFE---KLEG--KEFS 411
G+HM H YDFYKP++ SEYP+VDGKLS CYL ALD CY C K + EG K+F+
Sbjct: 195 GTHMQHAYDFYKPDMLSEYPIVDGKLSIQCYLSALDRCYSVYCKKIRAQWQKEGNDKDFT 254
Query: 410 INDADYFVFHSPYNKLVQKSFARLLYNDFLKNASSIDEAAKEGII---DLLAPGTYYLKE 240
+ND + +FHSPY KLVQKS AR+L NDFL + + + G+ D+ TY+ ++
Sbjct: 255 LNDFGFMIFHSPYCKLVQKSLARMLLNDFLNDQNRDKNSIYSGLEAFGDVKLEDTYFDRD 314
Query: 239 VDSLYRR 219
V+ + +
Sbjct: 315 VEKAFMK 321
>sp|Q01581|HMCS1_HUMAN Hydroxymethylglutaryl-CoA synthase, cytoplasmic OS=Homo
sapiens GN=HMGCS1 PE=1 SV=2
Length = 520
Score = 350 bits (896), Expect = 2e-095
Identities = 170/307 (55%), Positives = 221/307 (71%), Gaps = 8/307 (2%)
Frame = -2
Query: 1115 ENVGILAMDIYFPPTCVQQEALEAHDGASKGKYTIGLGQDCLAFCTELEDVISMSFNAVT 936
++VGI+A++IYFP V Q LE +DG GKYTIGLGQ + FCT+ ED+ S+ V
Sbjct: 15 KDVGIVALEIYFPSQYVDQAELEKYDGVDAGKYTIGLGQAKMGFCTDREDINSLCMTVVQ 74
Query: 935 SLLEKYKIDPKQIGRLEVGSETVIDKSKSIKTFLMQLFEKCGNTDVEGVDSTNACYGGTA 756
+L+E+ + IGRLEVG+ET+IDKSKS+KT LMQLFE+ GNTD+EG+D+TNACYGGTA
Sbjct: 75 NLMERNNLSYDCIGRLEVGTETIIDKSKSVKTNLMQLFEESGNTDIEGIDTTNACYGGTA 134
Query: 755 ALLNCVNWVESNSWDGRYGLVICTDSAVYAEGPARPTGGAAAIAMLIGPNAPIVFESKLR 576
A+ N VNW+ES+SWDGRY LV+ D AVYA G ARPTGG A+A+LIGPNAP++FE LR
Sbjct: 135 AVFNAVNWIESSSWDGRYALVVAGDIAVYATGNARPTGGVGAVALLIGPNAPLIFERGLR 194
Query: 575 GSHMAHVYDFYKPNLASEYPVVDGKLSQTCYLMALDSCYKHLCNKFE---KLEG--KEFS 411
G+HM H YDFYKP++ SEYP+VDGKLS CYL ALD CY C K + EG K+F+
Sbjct: 195 GTHMQHAYDFYKPDMLSEYPIVDGKLSIQCYLSALDRCYSVYCKKIHAQWQKEGNDKDFT 254
Query: 410 INDADYFVFHSPYNKLVQKSFARLLYNDFLKNASSIDEAAKEGII---DLLAPGTYYLKE 240
+ND + +FHSPY KLVQKS AR+L NDFL + + + G+ D+ TY+ ++
Sbjct: 255 LNDFGFMIFHSPYCKLVQKSLARMLLNDFLNDQNRDKNSIYSGLEAFGDVKLEDTYFDRD 314
Query: 239 VDSLYRR 219
V+ + +
Sbjct: 315 VEKAFMK 321
>sp|P23228|HMCS1_CHICK Hydroxymethylglutaryl-CoA synthase, cytoplasmic OS=Gallus
gallus GN=HMGCS1 PE=1 SV=1
Length = 522
Score = 344 bits (881), Expect = 1e-093
Identities = 167/279 (59%), Positives = 205/279 (73%), Gaps = 5/279 (1%)
Frame = -2
Query: 1127 STMAENVGILAMDIYFPPTCVQQEALEAHDGASKGKYTIGLGQDCLAFCTELEDVISMSF 948
S ++VGI+A++IYFP V Q LE +DG GKYTIGLGQ + FC++ ED+ S+
Sbjct: 11 SCWPKDVGIVALEIYFPSQYVDQTELEKYDGVDAGKYTIGLGQSKMGFCSDREDINSLCL 70
Query: 947 NAVTSLLEKYKIDPKQIGRLEVGSETVIDKSKSIKTFLMQLFEKCGNTDVEGVDSTNACY 768
V L+E+ + IGRLEVG+ET+IDKSKS+KT LMQLFE+ GNTDVEG+D+TNACY
Sbjct: 71 TVVQKLMERNSLSYDCIGRLEVGTETIIDKSKSVKTVLMQLFEESGNTDVEGIDTTNACY 130
Query: 767 GGTAALLNCVNWVESNSWDGRYGLVICTDSAVYAEGPARPTGGAAAIAMLIGPNAPIVFE 588
GGTAAL N +NW+ES+SWDGRY LV+ D AVYA G ARPTGGA A+AML+G NAP++FE
Sbjct: 131 GGTAALFNAINWIESSSWDGRYALVVAGDIAVYATGNARPTGGAGAVAMLVGSNAPLIFE 190
Query: 587 SKLRGSHMAHVYDFYKPNLASEYPVVDGKLSQTCYLMALDSCYKHLCNKFEKLEGKE--- 417
LRG+HM H YDFYKP++ SEYPVVDGKLS CYL ALD CY NK KE
Sbjct: 191 RGLRGTHMQHAYDFYKPDMVSEYPVVDGKLSIQCYLSALDRCYSVYRNKIHAQWQKEGTD 250
Query: 416 --FSINDADYFVFHSPYNKLVQKSFARLLYNDFLKNASS 306
F++ND + +FHSPY KLVQKS ARLL NDFL + ++
Sbjct: 251 RGFTLNDFGFMIFHSPYCKLVQKSVARLLLNDFLSDQNA 289
>sp|Q8JZK9|HMCS1_MOUSE Hydroxymethylglutaryl-CoA synthase, cytoplasmic OS=Mus
musculus GN=Hmgcs1 PE=1 SV=1
Length = 520
Score = 342 bits (877), Expect = 3e-093
Identities = 167/307 (54%), Positives = 219/307 (71%), Gaps = 8/307 (2%)
Frame = -2
Query: 1115 ENVGILAMDIYFPPTCVQQEALEAHDGASKGKYTIGLGQDCLAFCTELEDVISMSFNAVT 936
++VGI+A++IYFP V Q LE +DG GKYTIGLGQ + FCT+ ED+ S+ V
Sbjct: 15 KDVGIVALEIYFPSQYVDQAELEKYDGVDAGKYTIGLGQARMGFCTDREDINSLCLTVVQ 74
Query: 935 SLLEKYKIDPKQIGRLEVGSETVIDKSKSIKTFLMQLFEKCGNTDVEGVDSTNACYGGTA 756
L+E++ + IGRLEVG+ET+IDKSKS+K+ LMQLFE+ GNTD+EG+D+TNACYGGTA
Sbjct: 75 KLMERHSLSYDCIGRLEVGTETIIDKSKSVKSNLMQLFEESGNTDIEGIDTTNACYGGTA 134
Query: 755 ALLNCVNWVESNSWDGRYGLVICTDSAVYAEGPARPTGGAAAIAMLIGPNAPIVFESKLR 576
A+ N VNWVES+SWDGRY LV+ D A+YA G ARPTGG A+A+LIGPNAP++F+ LR
Sbjct: 135 AVFNAVNWVESSSWDGRYALVVAGDIAIYATGNARPTGGVGAVALLIGPNAPLIFDRGLR 194
Query: 575 GSHMAHVYDFYKPNLASEYPVVDGKLSQTCYLMALDSCYKHLCNKFE---KLEG--KEFS 411
G+HM H YDFYKP++ SEYPVVDGKLS CYL ALD CY K + EG K+F+
Sbjct: 195 GTHMQHAYDFYKPDMLSEYPVVDGKLSIQCYLSALDRCYSVYRKKIRAQWQKEGKDKDFT 254
Query: 410 INDADYFVFHSPYNKLVQKSFARLLYNDFLKNASSIDEAAKEGII---DLLAPGTYYLKE 240
+ND + +FHSPY KLVQKS AR+ NDFL + + + G+ D+ TY+ ++
Sbjct: 255 LNDFGFMIFHSPYCKLVQKSLARMFLNDFLNDQNRDKNSIYSGLEAFGDVKLEDTYFDRD 314
Query: 239 VDSLYRR 219
V+ + +
Sbjct: 315 VEKAFMK 321
>sp|P17425|HMCS1_RAT Hydroxymethylglutaryl-CoA synthase, cytoplasmic OS=Rattus
norvegicus GN=Hmgcs1 PE=1 SV=1
Length = 520
Score = 341 bits (874), Expect = 7e-093
Identities = 166/307 (54%), Positives = 218/307 (71%), Gaps = 8/307 (2%)
Frame = -2
Query: 1115 ENVGILAMDIYFPPTCVQQEALEAHDGASKGKYTIGLGQDCLAFCTELEDVISMSFNAVT 936
++VGI+A++IYFP V Q LE +DG GKYTIGLGQ + FCT+ ED+ S+ V
Sbjct: 15 KDVGIVALEIYFPSQYVDQAELEKYDGVDAGKYTIGLGQARMGFCTDREDINSLCLTVVQ 74
Query: 935 SLLEKYKIDPKQIGRLEVGSETVIDKSKSIKTFLMQLFEKCGNTDVEGVDSTNACYGGTA 756
L+E+ + IGRLEVG+ET+IDKSKS+K+ LMQLFE+ GNTD+EG+D+TNACYGGTA
Sbjct: 75 KLMERNSLSYDCIGRLEVGTETIIDKSKSVKSNLMQLFEESGNTDIEGIDTTNACYGGTA 134
Query: 755 ALLNCVNWVESNSWDGRYGLVICTDSAVYAEGPARPTGGAAAIAMLIGPNAPIVFESKLR 576
A+ N VNW+ES+SWDGRY LV+ D A+YA G ARPTGG A+A+LIGPNAP++F+ LR
Sbjct: 135 AVFNAVNWIESSSWDGRYALVVAGDIAIYASGNARPTGGVGAVALLIGPNAPVIFDRGLR 194
Query: 575 GSHMAHVYDFYKPNLASEYPVVDGKLSQTCYLMALDSCYKHLCNKFE---KLEG--KEFS 411
G+HM H YDFYKP++ SEYPVVDGKLS CYL ALD CY K + EG K+F+
Sbjct: 195 GTHMQHAYDFYKPDMLSEYPVVDGKLSIQCYLSALDRCYSVYRKKIRAQWQKEGKDKDFT 254
Query: 410 INDADYFVFHSPYNKLVQKSFARLLYNDFLKNASSIDEAAKEGII---DLLAPGTYYLKE 240
+ND + +FHSPY KLVQKS AR+ NDFL + + + G+ D+ TY+ ++
Sbjct: 255 LNDFGFMIFHSPYCKLVQKSLARMFLNDFLNDQNRDKNSIYSGLEAFGDVKLEDTYFDRD 314
Query: 239 VDSLYRR 219
V+ + +
Sbjct: 315 VEKAFMK 321
>sp|P13704|HMCS1_CRIGR Hydroxymethylglutaryl-CoA synthase, cytoplasmic
OS=Cricetulus griseus GN=HMGCS1 PE=3 SV=1
Length = 520
Score = 336 bits (860), Expect = 3e-091
Identities = 163/307 (53%), Positives = 215/307 (70%), Gaps = 8/307 (2%)
Frame = -2
Query: 1115 ENVGILAMDIYFPPTCVQQEALEAHDGASKGKYTIGLGQDCLAFCTELEDVISMSFNAVT 936
++VGI+A++IYFP V Q LE +DG GKYTIGLGQ + FCT+ ED+ S+ V
Sbjct: 15 KDVGIVALEIYFPSQYVDQAELEKYDGVDAGKYTIGLGQARMGFCTDREDINSLCLTVVQ 74
Query: 935 SLLEKYKIDPKQIGRLEVGSETVIDKSKSIKTFLMQLFEKCGNTDVEGVDSTNACYGGTA 756
+L+E+ + IGRLEVG+ET+IDKSKS+K+ LMQLFE+ GNTD+EG+D+TNACYGGTA
Sbjct: 75 NLMERNSLSYDCIGRLEVGTETIIDKSKSVKSNLMQLFEESGNTDIEGIDTTNACYGGTA 134
Query: 755 ALLNCVNWVESNSWDGRYGLVICTDSAVYAEGPARPTGGAAAIAMLIGPNAPIVFESKLR 576
A+ N VNW+ES+SWDGRY LV+ D A+YA G ARPTGG A+A+LIGPNAP++F+ LR
Sbjct: 135 AVFNAVNWIESSSWDGRYALVVAGDIAIYATGNARPTGGVGAVALLIGPNAPLIFDRGLR 194
Query: 575 GSHMAHVYDFYKPNLASEYPVVDGKLSQTCYLMALDSCYKHLCNKFEKLEGKE-----FS 411
G+HM H YDFYKP++ SEYP+VDGKLS CYL ALD CY K KE F+
Sbjct: 195 GTHMQHAYDFYKPDMLSEYPIVDGKLSIQCYLSALDRCYSVYRKKIRAQWQKEGNDNDFT 254
Query: 410 INDADYFVFHSPYNKLVQKSFARLLYNDFLKNASSIDEAAKEGII---DLLAPGTYYLKE 240
+ND + + HSPY KLVQKS AR+ NDFL + + + G+ D+ TY+ ++
Sbjct: 255 LNDFGFMISHSPYCKLVQKSLARMFLNDFLNDQNRDKNSIYSGLEAFGDVKLEDTYFDRD 314
Query: 239 VDSLYRR 219
V+ + +
Sbjct: 315 VEKAFMK 321
>sp|Q86HL5|HMCSB_DICDI Hydroxymethylglutaryl-CoA synthase B OS=Dictyostelium
discoideum GN=hgsB PE=3 SV=1
Length = 468
Score = 334 bits (855), Expect = 1e-090
Identities = 156/271 (57%), Positives = 206/271 (76%), Gaps = 1/271 (0%)
Frame = -2
Query: 1115 ENVGILAMDIYFPPTCVQQEALEAHDGASKGKYTIGLGQDCLAFCTELEDVISMSFNAVT 936
+++GI A+DIYFP T V Q L+ +D S GKYTIGLGQ ++F + ED++SM+ +V
Sbjct: 5 KDIGICAIDIYFPQTYVNQSELKKYDKVSNGKYTIGLGQTNMSFVGDREDIVSMAMTSVK 64
Query: 935 SLLEKYKIDPKQIGRLEVGSETVIDKSKSIKTFLMQLFEKCGNTDVEGVDSTNACYGGTA 756
++ KY ID + IGRLEVG+ET+IDKSKS+K+ +M LF++ GNT +EGVD+ NACYGGT
Sbjct: 65 MMMSKYSIDYQSIGRLEVGTETIIDKSKSVKSSIMSLFQEYGNTSLEGVDTLNACYGGTN 124
Query: 755 ALLNCVNWVESNSWDGRYGLVICTDSAVYAEGPARPTGGAAAIAMLIGPNAPIVFESKLR 576
AL N + W+ES+ WDGRY LV+ D AVY++G ARPTGGA + MLIGPNA ++F+ LR
Sbjct: 125 ALFNSLQWIESSYWDGRYALVVTGDIAVYSKGAARPTGGAGVVTMLIGPNATLIFDQSLR 184
Query: 575 GSHMAHVYDFYKPNLASEYPVVDGKLSQTCYLMALDSCYKHLCNKFEKL-EGKEFSINDA 399
G+HM +V DFYKP+L+SEYP VDGKLS CYL ALD CY KFE + + +FS++
Sbjct: 185 GTHMENVNDFYKPDLSSEYPYVDGKLSIECYLRALDKCYLEYKKKFESINDDNKFSMDSF 244
Query: 398 DYFVFHSPYNKLVQKSFARLLYNDFLKNASS 306
DY FHSPYN+LVQKS+ARL+YNDFL+N ++
Sbjct: 245 DYVCFHSPYNRLVQKSYARLIYNDFLQNPNN 275
>sp|P54868|HMCS2_HUMAN Hydroxymethylglutaryl-CoA synthase, mitochondrial OS=Homo
sapiens GN=HMGCS2 PE=1 SV=1
Length = 508
Score = 332 bits (850), Expect = 4e-090
Identities = 160/305 (52%), Positives = 217/305 (71%), Gaps = 8/305 (2%)
Frame = -2
Query: 1124 TMAENVGILAMDIYFPPTCVQQEALEAHDGASKGKYTIGLGQDCLAFCTELEDVISMSFN 945
T ++VGILA+++YFP V Q LE ++ GKYT+GLGQ + FC+ ED+ S+
Sbjct: 49 TWPKDVGILALEVYFPAQYVDQTDLEKYNNVEAGKYTVGLGQTRMGFCSVQEDINSLCLT 108
Query: 944 AVTSLLEKYKIDPKQIGRLEVGSETVIDKSKSIKTFLMQLFEKCGNTDVEGVDSTNACYG 765
V L+E+ ++ +GRLEVG+ET+IDKSK++KT LM+LF+ GNTD+EG+D+TNACYG
Sbjct: 109 VVQRLMERIQLPWDSVGRLEVGTETIIDKSKAVKTVLMELFQDSGNTDIEGIDTTNACYG 168
Query: 764 GTAALLNCVNWVESNSWDGRYGLVICTDSAVYAEGPARPTGGAAAIAMLIGPNAPIVFES 585
GTA+L N NW+ES+SWDGRY +V+C D AVY G ARPTGGA A+AMLIGP AP+ E
Sbjct: 169 GTASLFNAANWMESSSWDGRYAMVVCGDIAVYPSGNARPTGGAGAVAMLIGPKAPLALER 228
Query: 584 KLRGSHMAHVYDFYKPNLASEYPVVDGKLSQTCYLMALDSCY----KHLCNKFEKL-EGK 420
LRG+HM +VYDFYKPNLASEYP+VDGKLS CYL ALD CY K + N++++ +
Sbjct: 229 GLRGTHMENVYDFYKPNLASEYPIVDGKLSIQCYLRALDRCYTSYRKKIQNQWKQAGSDR 288
Query: 419 EFSINDADYFVFHSPYNKLVQKSFARLLYNDFLKNASSIDEAAKEGII---DLLAPGTYY 249
F+++D Y +FH+P+ K+VQKS ARL++NDFL +S + +G+ L TY
Sbjct: 289 PFTLDDLQYMIFHTPFCKMVQKSLARLMFNDFLSASSDTQTSLYKGLEAFGGLKLEDTYT 348
Query: 248 LKEVD 234
K++D
Sbjct: 349 NKDLD 353
>sp|P54961|HMCS1_BLAGE Hydroxymethylglutaryl-CoA synthase 1 OS=Blattella
germanica GN=HMGCS-1 PE=2 SV=1
Length = 453
Score = 331 bits (848), Expect = 7e-090
Identities = 164/297 (55%), Positives = 215/297 (72%), Gaps = 7/297 (2%)
Frame = -2
Query: 1112 NVGILAMDIYFPPTCVQQEALEAHDGASKGKYTIGLGQDCLAFCTELEDVISMSFNAVTS 933
+VGI+A+++ FP V Q LE +D S GKYT+GLGQ + FCT+ ED+ S+ V+
Sbjct: 5 DVGIVALELIFPSQYVDQVDLEVYDNVSAGKYTVGLGQARMGFCTDREDINSLCLTVVSR 64
Query: 932 LLEKYKIDPKQIGRLEVGSETVIDKSKSIKTFLMQLFEKCGNTDVEGVDSTNACYGGTAA 753
L+E++ I QIGRLEVG+ET++DKSKS+KT LMQLF+ NTD+EGVD+ NACYGGT+A
Sbjct: 65 LMERWSIPYSQIGRLEVGTETLLDKSKSVKTVLMQLFK--DNTDIEGVDTVNACYGGTSA 122
Query: 752 LLNCVNWVESNSWDGRYGLVICTDSAVYAEGPARPTGGAAAIAMLIGPNAPIVFESKLRG 573
L N ++WVES+SWDGRY LV+ D AVYA+G ARPTGGA A+AML+G NAP+VF+ +R
Sbjct: 123 LFNAISWVESSSWDGRYALVVAGDIAVYAKGSARPTGGAGAVAMLVGANAPLVFDRGVRS 182
Query: 572 SHMAHVYDFYKPNLASEYPVVDGKLSQTCYLMALDSCYKHLCNKFEKLEGKEFSINDADY 393
SHM H YDFYKP+L+S YP VDGKLS CYL ALD CY+ C+K +K G++F I D
Sbjct: 183 SHMQHAYDFYKPDLSSLYPTVDGKLSIQCYLSALDHCYQLYCSKIQKQLGEKFDIERLDA 242
Query: 392 FVFHSPYNKLVQKSFARLLYNDFLKNASSIDEAAKEGIIDLL----APGTYYLKEVD 234
+FH+PY KLVQKS ARL+ NDF++ AS + K ++ L TY+ +EV+
Sbjct: 243 VLFHAPYCKLVQKSLARLVLNDFVR-ASEEERTTKYSSLEALKGVKLEDTYFDREVE 298
>sp|P54869|HMCS2_MOUSE Hydroxymethylglutaryl-CoA synthase, mitochondrial OS=Mus
musculus GN=Hmgcs2 PE=1 SV=2
Length = 508
Score = 330 bits (846), Expect = 1e-089
Identities = 162/305 (53%), Positives = 215/305 (70%), Gaps = 8/305 (2%)
Frame = -2
Query: 1124 TMAENVGILAMDIYFPPTCVQQEALEAHDGASKGKYTIGLGQDCLAFCTELEDVISMSFN 945
T ++VGILA+++YFP V Q LE + GKYT+GLGQ + FC+ ED+ S+
Sbjct: 49 TWPKDVGILALEVYFPAQYVDQTDLEKFNNVEAGKYTVGLGQTRMGFCSVQEDINSLCLT 108
Query: 944 AVTSLLEKYKIDPKQIGRLEVGSETVIDKSKSIKTFLMQLFEKCGNTDVEGVDSTNACYG 765
V L+E+ K+ +GRLEVG+ET+IDKSK++KT LM+LF+ GNTD+EG+D+TNACYG
Sbjct: 109 VVQRLMERTKLPWDAVGRLEVGTETIIDKSKAVKTVLMELFQDSGNTDIEGIDTTNACYG 168
Query: 764 GTAALLNCVNWVESNSWDGRYGLVICTDSAVYAEGPARPTGGAAAIAMLIGPNAPIVFES 585
GTA+L N NW+ES+ WDGRY LV+C D AVY G ARPTGGA A+AMLIGP AP+V E
Sbjct: 169 GTASLFNAANWMESSYWDGRYALVVCGDIAVYPSGNARPTGGAGAVAMLIGPKAPLVLEQ 228
Query: 584 KLRGSHMAHVYDFYKPNLASEYPVVDGKLSQTCYLMALDSCY----KHLCNKFEKL-EGK 420
LRG+HM + YDFYKPNLASEYP+VDGKLS CYL ALD CY K + N++++ +
Sbjct: 229 GLRGTHMENAYDFYKPNLASEYPLVDGKLSIQCYLRALDRCYAAYRKKIQNQWKQAGNNQ 288
Query: 419 EFSINDADYFVFHSPYNKLVQKSFARLLYNDFLKNASSIDEAAKEGI---IDLLAPGTYY 249
F+++D Y +FH+P+ K+VQKS ARL++NDFL ++S +G+ L TY
Sbjct: 289 PFTLDDVQYMIFHTPFCKMVQKSLARLMFNDFLSSSSDKQNNLYKGLEAFRGLKLEETYT 348
Query: 248 LKEVD 234
K+VD
Sbjct: 349 NKDVD 353
>sp|Q2KIE6|HMCS2_BOVIN Hydroxymethylglutaryl-CoA synthase, mitochondrial OS=Bos
taurus GN=HMGCS2 PE=2 SV=1
Length = 508
Score = 329 bits (843), Expect = 3e-089
Identities = 161/308 (52%), Positives = 211/308 (68%), Gaps = 8/308 (2%)
Frame = -2
Query: 1124 TMAENVGILAMDIYFPPTCVQQEALEAHDGASKGKYTIGLGQDCLAFCTELEDVISMSFN 945
T ++VGILAM++YFP V Q LE + G+YT+GLGQ + FC+ EDV S+
Sbjct: 49 TWPKDVGILAMEVYFPAQYVDQTELEKFNKVEAGRYTVGLGQTQMGFCSVQEDVNSLCLT 108
Query: 944 AVTSLLEKYKIDPKQIGRLEVGSETVIDKSKSIKTFLMQLFEKCGNTDVEGVDSTNACYG 765
V L+E+ ++ +GRLEVG+ET+IDKSK++KT LM+LF+ GNTD+EG+D+TNACYG
Sbjct: 109 VVQQLMERTQLPWDSVGRLEVGTETIIDKSKAVKTVLMELFQDSGNTDIEGIDTTNACYG 168
Query: 764 GTAALLNCVNWVESNSWDGRYGLVICTDSAVYAEGPARPTGGAAAIAMLIGPNAPIVFES 585
GTA+L N NW+ES+SWDGRY LV+C D AVY G ARPTGGA A+AML+GP AP+V E
Sbjct: 169 GTASLFNAANWMESSSWDGRYALVVCGDIAVYPSGNARPTGGAGAVAMLVGPEAPLVLER 228
Query: 584 KLRGSHMAHVYDFYKPNLASEYPVVDGKLSQTCYLMALDSCYKHLCNKFEKL-----EGK 420
LRG+HM +VYDFYKP++ SEYP+VDGKLS CYL ALD CY K EK +
Sbjct: 229 GLRGTHMENVYDFYKPDVTSEYPLVDGKLSIQCYLRALDKCYAFYRQKIEKQWKQAGIDR 288
Query: 419 EFSINDADYFVFHSPYNKLVQKSFARLLYNDFLKNASSIDEAAKEGI---IDLLAPGTYY 249
F+++D Y +FH+P+ KLVQKS ARL++NDFL + +G+ L TY
Sbjct: 289 PFTLDDVQYMIFHTPFCKLVQKSLARLMFNDFLLASGDTQTGIYKGLEAFRGLKLEDTYT 348
Query: 248 LKEVDSLY 225
K+VD +
Sbjct: 349 NKDVDKAF 356
>sp|P22791|HMCS2_RAT Hydroxymethylglutaryl-CoA synthase, mitochondrial OS=Rattus
norvegicus GN=Hmgcs2 PE=2 SV=1
Length = 508
Score = 327 bits (838), Expect = 1e-088
Identities = 160/305 (52%), Positives = 209/305 (68%), Gaps = 8/305 (2%)
Frame = -2
Query: 1124 TMAENVGILAMDIYFPPTCVQQEALEAHDGASKGKYTIGLGQDCLAFCTELEDVISMSFN 945
T ++VGILA+++YFP V Q LE + GKYT+GLGQ + FC+ ED+ S+
Sbjct: 49 TWPKDVGILALEVYFPAQYVDQTDLEKFNNVEAGKYTVGLGQTRMGFCSVQEDINSLCLT 108
Query: 944 AVTSLLEKYKIDPKQIGRLEVGSETVIDKSKSIKTFLMQLFEKCGNTDVEGVDSTNACYG 765
V L+E+ K+ +GRLEVG+ET+IDKSK++KT LM+LF+ GNTD+EG+D+TNACYG
Sbjct: 109 VVQRLMERTKLPWDAVGRLEVGTETIIDKSKAVKTVLMELFQDSGNTDIEGIDTTNACYG 168
Query: 764 GTAALLNCVNWVESNSWDGRYGLVICTDSAVYAEGPARPTGGAAAIAMLIGPNAPIVFES 585
GTA+L N NW+ES+ WDGRY LV+C D AVY G RPTGGA A+AMLIGP AP+V E
Sbjct: 169 GTASLFNAANWMESSYWDGRYALVVCGDIAVYPSGNPRPTGGAGAVAMLIGPKAPLVLEQ 228
Query: 584 KLRGSHMAHVYDFYKPNLASEYPVVDGKLSQTCYLMALDSCYKHLCNKFEKL-----EGK 420
LRG+HM + YDFYKPNLASEYP+VDGKLS CYL ALD CY K + +
Sbjct: 229 GLRGTHMENAYDFYKPNLASEYPLVDGKLSIQCYLRALDRCYAAYRRKIQNQWKQAGNNQ 288
Query: 419 EFSINDADYFVFHSPYNKLVQKSFARLLYNDFLKNASSIDEAAKEGI---IDLLAPGTYY 249
F+++D Y +FH+P+ K+VQKS ARL++NDFL ++S +G+ L TY
Sbjct: 289 PFTLDDVQYMIFHTPFCKMVQKSLARLMFNDFLSSSSDKQNNLYKGLEAFKGLKLEETYT 348
Query: 248 LKEVD 234
K+VD
Sbjct: 349 NKDVD 353
>sp|P54870|HMCS2_BLAGE Hydroxymethylglutaryl-CoA synthase 2 OS=Blattella
germanica GN=HMGCS-2 PE=2 SV=1
Length = 455
Score = 318 bits (813), Expect = 8e-086
Identities = 162/303 (53%), Positives = 209/303 (68%), Gaps = 9/303 (2%)
Frame = -2
Query: 1115 ENVGILAMDIYFPPTCVQQEALEAHDGASKGKYTIGLGQDCLAFCTELEDVISMSFNAVT 936
E+VGI+ +++ FP V Q LE +D S GKYT+GLGQD + CT+ ED+ S+ AV
Sbjct: 6 EDVGIIGIEMIFPSLYVDQAELETYDEVSPGKYTMGLGQDKMGVCTDREDINSLCLTAVD 65
Query: 935 SLLEKYKIDPKQIGRLEVGSETVIDKSKSIKTFLMQLFEKCGNTDVEGVDSTNACYGGTA 756
L+E+ ID IG LEVG+ET++DK KS+KT LMQLFE+ GNTDVEG+D+ NACY GTA
Sbjct: 66 KLMERNNIDYNDIGWLEVGTETILDKVKSVKTVLMQLFEESGNTDVEGIDTINACYRGTA 125
Query: 755 ALLNCVNWVESNSWDGRYGLVICTDSAVYAEGPARPTGGAAAIAMLIGPNAPIVFESKLR 576
AL N + W+ES+SWDGRY +V+ D A+YA+ PTGGA A+ MLIG NAPIV + +R
Sbjct: 126 ALFNALIWIESSSWDGRYAIVVAADIAIYAK-ECSPTGGAGALLMLIGANAPIVIDRGVR 184
Query: 575 GSHMAHVYDFYKPNLASEYPVVDGKLSQTCYLMALDSCYKHLCNKFEKLE---GKEFSIN 405
SHM H YDFYKP+L SEYPVVDGKLS CYL ALD CY C+K EK GKE +
Sbjct: 185 ASHMKHAYDFYKPDLMSEYPVVDGKLSVQCYLSALDHCYPRFCSKTEKYLKRCGKENTKI 244
Query: 404 DADY---FVFHSPYNKLVQKSFARLLYNDFLKNASSIDEAAKEGIIDLLAPGTYYLKEVD 234
D DY FVFHSPY KLVQKS ARL+ NDF++ + + + +L TY+ ++++
Sbjct: 245 DLDYFDAFVFHSPYCKLVQKSVARLVLNDFIQYPEKYQDL--QQLRNLKFEDTYFDRDIE 302
Query: 233 SLY 225
++
Sbjct: 303 KIF 305
>sp|O02734|HMCS2_PIG Hydroxymethylglutaryl-CoA synthase, mitochondrial OS=Sus
scrofa GN=HMGCS2 PE=2 SV=1
Length = 508
Score = 318 bits (813), Expect = 8e-086
Identities = 154/311 (49%), Positives = 211/311 (67%), Gaps = 10/311 (3%)
Frame = -2
Query: 1124 TMAENVGILAMDIYFPPTCVQQEALEAHDGASKGKYTIGLGQDCLAFCTELEDVISMSFN 945
T ++VGILA+++YFP V Q LE D G+YT+GLGQ + FC+ ED+ S+
Sbjct: 49 TWPKDVGILALEVYFPAQYVDQTDLEKFDNVEAGRYTVGLGQTHMGFCSVQEDINSLCLT 108
Query: 944 AVTSLLEKYKIDPKQIGRLEVGSETVIDKSKSIKTFLMQLFEKCGNTDVEGVDSTNACYG 765
V L+E+ ++ +G LEVG+ET+IDKSKS+KT LM+LF+ GNTD+EG+D+TNACYG
Sbjct: 109 VVQRLMERTQLPWDSVGWLEVGTETIIDKSKSVKTVLMELFQDSGNTDIEGIDTTNACYG 168
Query: 764 GTAALLNCVNWVESNSWDGRYGLVICTDSAVYAEGPARPTGGAAAIAMLIGPNAPIVFES 585
GTA+L N NWVES++WDGRY +V+C D AVY G +RPTGGA A+AML+GP AP+ E
Sbjct: 169 GTASLFNAANWVESSAWDGRYAVVVCGDIAVYPRGNSRPTGGAGAVAMLVGPEAPLALER 228
Query: 584 KLRGSHMAHVYDFYKPNLASEYPVVDGKLSQTCYLMALDSCYKHLCNKFEK------LEG 423
LRG+HM + YDFYKPN SEYP+VDGKLS CYL ALD CY K EK +E
Sbjct: 229 GLRGTHMENAYDFYKPNATSEYPLVDGKLSIQCYLRALDRCYTLYRQKIEKQWKQAGIE- 287
Query: 422 KEFSINDADYFVFHSPYNKLVQKSFARLLYNDFLKNASSIDEAAKEGIIDLLA---PGTY 252
+ F+++D + +FH+P+ KLVQKS ARL+++DFL S + +G+ TY
Sbjct: 288 RHFTLDDLQFMIFHTPFCKLVQKSLARLMFSDFLLADSDTQSSLYKGLEAFRGQKLEDTY 347
Query: 251 YLKEVDSLYRR 219
K+++ +++
Sbjct: 348 ANKDIEKAFQK 358
>sp|P54839|HMCS_YEAST Hydroxymethylglutaryl-CoA synthase OS=Saccharomyces
cerevisiae GN=ERG13 PE=1 SV=1
Length = 491
Score = 305 bits (779), Expect = 7e-082
Identities = 159/297 (53%), Positives = 197/297 (66%), Gaps = 11/297 (3%)
Frame = -2
Query: 1151 KKKSFRYHSTMAENVGILAMDIYFPPTCVQQEALEAHDGASKGKYTIGLGQDCLAFCTEL 972
KK+ T +NVGI + IY P CV Q LE DG S+GKYTIGLGQ ++F +
Sbjct: 35 KKQKTAEQKTRPQNVGIKGIQIYIPTQCVNQSELEKFDGVSQGKYTIGLGQTNMSFVNDR 94
Query: 971 EDVISMSFNAVTSLLEKYKIDPKQIGRLEVGSETVIDKSKSIKTFLMQLFEKCGNTDVEG 792
ED+ SMS ++ L++ Y ID +IGRLEVG+ET+IDKSKS+K+ LMQLF + NTDVEG
Sbjct: 95 EDIYSMSLTVLSKLIKSYNIDTNKIGRLEVGTETLIDKSKSVKSVLMQLFGE--NTDVEG 152
Query: 791 VDSTNACYGGTAALLNCVNWVESNSWDGRYGLVICTDSAVYAEGPARPTGGAAAIAMLIG 612
+D+ NACYGGT AL N +NW+ESN+WDGR +V+C D A+Y +G ARPTGGA +AM IG
Sbjct: 153 IDTLNACYGGTNALFNSLNWIESNAWDGRDAIVVCGDIAIYDKGAARPTGGAGTVAMWIG 212
Query: 611 PNAPIVFESKLRGSHMAHVYDFYKPNLASEYPVVDGKLSQTCYLMALDSCYKHLCNK-FE 435
P+APIVF+S +R S+M H YDFYKP+ SEYP VDG S TCY+ ALD YK K
Sbjct: 213 PDAPIVFDS-VRASYMEHAYDFYKPDFTSEYPYVDGHFSLTCYVKALDQVYKSYSKKAIS 271
Query: 434 KLEGKEFSINDA-------DYFVFHSPYNKLVQKSFARLLYNDFLKNASSIDEAAKE 285
K + + +DA DY VFH P KLV KS+ RLLYNDF N E E
Sbjct: 272 KGLVSDPAGSDALNVLKYFDYNVFHVPTCKLVTKSYGRLLYNDFRANPQLFPEVDAE 328
>sp|P54874|HMCS_SCHPO Hydroxymethylglutaryl-CoA synthase OS=Schizosaccharomyces
pombe GN=hcs1 PE=1 SV=1
Length = 447
Score = 292 bits (747), Expect = 3e-078
Identities = 147/286 (51%), Positives = 198/286 (69%), Gaps = 7/286 (2%)
Frame = -2
Query: 1115 ENVGILAMDIYFPPTCVQQEALEAHDGASKGKYTIGLGQDCLAFCTELEDVISMSFNAVT 936
+++GI + +Y P V+Q ALEAHDG S GKYTIGLG +AF + ED+ S A++
Sbjct: 6 KDIGIKGLVLYTPNQYVEQAALEAHDGVSTGKYTIGLGLTKMAFVDDREDIYSFGLTALS 65
Query: 935 SLLEKYKIDPKQIGRLEVGSETVIDKSKSIKTFLMQLFEKCGNTDVEGVDSTNACYGGTA 756
L+++Y+ID +IGRLEVG+ET+IDKSKS+K+ LMQLF N +VEG+D NACYGG
Sbjct: 66 QLIKRYQIDISKIGRLEVGTETIIDKSKSVKSVLMQLFG--DNHNVEGIDCVNACYGGVN 123
Query: 755 ALLNCVNWVESNSWDGRYGLVICTDSAVYAEGPARPTGGAAAIAMLIGPNAPIVFESKLR 576
AL N ++W+ES++WDGR G+V+ D A+YA+G ARPTGGA +A+L+GPNAPIVFE LR
Sbjct: 124 ALFNTIDWIESSAWDGRDGIVVAGDIALYAKGNARPTGGAGCVALLVGPNAPIVFEPGLR 183
Query: 575 GSHMAHVYDFYKPNLASEYPVVDGKLSQTCYLMALDSCYKHLCNKFEKLEGKE--FSIND 402
G++M H YDFYKP+L SEYP VDG S CY+ ALD Y + + GK ++
Sbjct: 184 GTYMQHAYDFYKPDLTSEYPYVDGHFSLECYVKALDGAYANYNVRDVAKNGKSQGLGLDR 243
Query: 401 ADYFVFHSPYNKLVQKSFARLLYNDFLKNASSIDEAAKEGIIDLLA 264
DY +FH+P K VQK++ARLLY D +A+ EG+ +LL+
Sbjct: 244 FDYCIFHAPTCKQVQKAYARLLYTD---SAAEPSNPELEGVRELLS 286
>sp|P54871|HMCS_CAEEL Hydroxymethylglutaryl-CoA synthase OS=Caenorhabditis
elegans GN=F25B4.6 PE=2 SV=2
Length = 462
Score = 232 bits (591), Expect = 4e-060
Identities = 125/269 (46%), Positives = 166/269 (61%), Gaps = 5/269 (1%)
Frame = -2
Query: 1124 TMAENVGILAMDIYFPPTCVQQEALEAHDGASKGKYTIGLGQDCLAFCTELEDVISMSFN 945
T +VGI A+++YFP V Q LE + S GKYTIGLGQ + FC++ ED++S+S
Sbjct: 9 TPVTDVGIGAIELYFPQNFVDQNDLEKFNNVSSGKYTIGLGQQQMGFCSDNEDIVSISLT 68
Query: 944 AVTSLLEKYKIDPKQIGRLEVGSETVIDKSKSIKTFLMQLFEKCGNTDVEGVDSTNACYG 765
L+E YKI IG L VG+ET+IDKSKS+KT LM LF GN+D+EGVD NAC+G
Sbjct: 69 VTRKLIETYKISTDSIGCLVVGTETMIDKSKSVKTALMDLFP--GNSDIEGVDIKNACFG 126
Query: 764 GTAALLNCVNWVESN-SWDGRYGLVICTDSAVYAEGPARPTGGAAAIAMLIGPNAPIVFE 588
G ALL+ ++WV N D + +V+ D A+Y EGPAR TGGA AIA LI P+A I +
Sbjct: 127 GAQALLHAIDWVTVNHPLDKKNAIVVVADIAIYEEGPARCTGGAGAIAFLICPDASIPID 186
Query: 587 SKLRGSHMAHVYDFYKP--NLASEYPVVDGKLSQTCYLMALDSCYKHLCNKFEKLEGKEF 414
+ HM + +DF+KP + SEYPVVDG LS + YL A+ Y + +K +
Sbjct: 187 RQFSACHMKNTWDFFKPITPIPSEYPVVDGSLSLSSYLEAVRMTYTYFISKVNRHTTGID 246
Query: 413 SINDADYFVFHSPYNKLVQKSFARLLYND 327
+N D HSP+ K+VQK A + Y D
Sbjct: 247 GLNSFDGVFLHSPFTKMVQKGLAVMNYTD 275
Database: UniProt/SwissProt
Posted date: Sat Aug 07 14:36:18 2010
Number of letters in database: 182,829,261
Number of sequences in database: 518,415
Lambda K H
0.267 0.041 0.140
Gapped
Lambda K H
0.267 0.041 0.140
Matrix: blosum62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 186,100,387,091
Number of Sequences: 518415
Number of Extensions: 186100387091
Number of Successful Extensions: 1135017718
Number of sequences better than 0.0: 0
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