BLASTX 7.6.2
Query= UN50342 /QuerySize=1223
(1222 letters)
Database: UniProt/SwissProt;
518,415 sequences; 182,829,261 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q5ZLS7|GLYR1_CHICK Putative oxidoreductase GLYR1 OS=Gallus ga... 180 2e-044
sp|A4FUF0|GLYR1_BOVIN Putative oxidoreductase GLYR1 OS=Bos tauru... 179 5e-044
sp|Q922P9|GLYR1_MOUSE Putative oxidoreductase GLYR1 OS=Mus muscu... 179 5e-044
sp|Q5RKH0|GLYR1_RAT Putative oxidoreductase GLYR1 OS=Rattus norv... 179 5e-044
sp|Q49A26|GLYR1_HUMAN Putative oxidoreductase GLYR1 OS=Homo sapi... 177 2e-043
sp|Q5R7T2|GLYR1_PONAB Putative oxidoreductase GLYR1 OS=Pongo abe... 176 5e-043
sp|Q562D5|GLYR1_XENTR Putative oxidoreductase GLYR1 OS=Xenopus t... 174 2e-042
sp|Q5RKN4|GLYR1_DANRE Putative oxidoreductase GLYR1 OS=Danio rer... 168 7e-041
sp|Q175F8|GLYR1_AEDAE Putative oxidoreductase GLYR1 homolog OS=A... 164 1e-039
sp|Q7Q161|GLYR1_ANOGA Putative oxidoreductase GLYR1 homolog OS=A... 162 7e-039
sp|Q29NG1|GLYR1_DROPS Putative oxidoreductase GLYR1 homolog OS=D... 132 8e-030
sp|P77161|GLXR_ECOLI 2-hydroxy-3-oxopropionate reductase OS=Esch... 116 3e-025
sp|P0ABQ3|GARR_ECOL6 2-hydroxy-3-oxopropionate reductase OS=Esch... 107 2e-022
sp|P0ABQ2|GARR_ECOLI 2-hydroxy-3-oxopropionate reductase OS=Esch... 107 2e-022
sp|P28811|MMSB_PSEAE 3-hydroxyisobutyrate dehydrogenase OS=Pseud... 102 7e-021
sp|P31937|3HIDH_HUMAN 3-hydroxyisobutyrate dehydrogenase, mitoch... 102 9e-021
sp|Q5R5E7|3HIDH_PONAB 3-hydroxyisobutyrate dehydrogenase, mitoch... 102 9e-021
sp|P29266|3HIDH_RAT 3-hydroxyisobutyrate dehydrogenase, mitochon... 101 1e-020
sp|Q99L13|3HIDH_MOUSE 3-hydroxyisobutyrate dehydrogenase, mitoch... 100 2e-020
sp|Q2HJD7|3HIDH_BOVIN 3-hydroxyisobutyrate dehydrogenase, mitoch... 99 6e-020
>sp|Q5ZLS7|GLYR1_CHICK Putative oxidoreductase GLYR1 OS=Gallus gallus GN=GLYR1
PE=2 SV=1
Length = 553
Score = 180 bits (455), Expect = 2e-044
Identities = 95/216 (43%), Positives = 138/216 (63%)
Frame = +2
Query: 362 KVQSMLPVGKNGAVSGISSGKGYVDVSTVDAASSVLISKQIKDTGALFLEAPVSGSKKPA 541
K L +G +G + GI GK YVD+STVDA + +++ I G FLEAPVSG+++ +
Sbjct: 335 KAAKDLVLGPSGVLQGIRPGKCYVDMSTVDADTVTELAQVIVSRGGRFLEAPVSGNQQLS 394
Query: 542 EDGQLIFLTAGDKLLYEKAAPFLDIMGKSRFYLGDVGNGAAMKLVVNMIMGSMMASFAEG 721
DG L+ L AGD+ LYE + MGK+ F+LG+VGN A M L+VNM+ GS MA+ AEG
Sbjct: 395 NDGMLVILAAGDRGLYEDCSSCFQAMGKTSFFLGEVGNAAKMMLIVNMVQGSFMATIAEG 454
Query: 722 ILLSQKVGLDPNVLVEVVSQGAINAPMYSLKGPSMIKSVYPTAFPLKHHQKDMRLALGLA 901
+ L+Q G L+++++QG + + K ++++ + F LK+ QKD+RLA+ L
Sbjct: 455 LTLAQVTGQSQQTLLDILNQGQLASIFLDQKCQNILQGNFKPDFYLKYIQKDLRLAIALG 514
Query: 902 ESVSQSTPIAAAANELYKVAKSYGLSDEDFFAVIEA 1009
+SV+ TP+AAAANE+YK AK+ SD D AV A
Sbjct: 515 DSVNHPTPMAAAANEVYKRAKALDQSDNDMSAVYRA 550
>sp|A4FUF0|GLYR1_BOVIN Putative oxidoreductase GLYR1 OS=Bos taurus GN=GLYR1 PE=2
SV=1
Length = 553
Score = 179 bits (452), Expect = 5e-044
Identities = 94/216 (43%), Positives = 138/216 (63%)
Frame = +2
Query: 362 KVQSMLPVGKNGAVSGISSGKGYVDVSTVDAASSVLISKQIKDTGALFLEAPVSGSKKPA 541
K L +G +G + GI GK YVD+STVDA + +++ I G FLEAPVSG+++ +
Sbjct: 335 KAAKDLVLGPSGVLQGIRPGKCYVDMSTVDADTVTELAQVIVSRGGRFLEAPVSGNQQLS 394
Query: 542 EDGQLIFLTAGDKLLYEKAAPFLDIMGKSRFYLGDVGNGAAMKLVVNMIMGSMMASFAEG 721
DG L+ L AGD+ LYE + MGK+ F+LG+VGN A M L+VNM+ GS MA+ AEG
Sbjct: 395 NDGMLVILAAGDRGLYEDCSSCFQAMGKTSFFLGEVGNAAKMMLIVNMVQGSFMATIAEG 454
Query: 722 ILLSQKVGLDPNVLVEVVSQGAINAPMYSLKGPSMIKSVYPTAFPLKHHQKDMRLALGLA 901
+ L+Q G L+++++QG + + K ++++ + F LK+ QKD+RLA+ L
Sbjct: 455 LTLAQVTGQSQQTLLDILNQGQLASIFLDQKCQNILQGNFKPDFYLKYIQKDLRLAIALG 514
Query: 902 ESVSQSTPIAAAANELYKVAKSYGLSDEDFFAVIEA 1009
++V+ TP+AAAANE+YK AK+ SD D AV A
Sbjct: 515 DAVNHPTPMAAAANEVYKRAKALDQSDNDMSAVYRA 550
>sp|Q922P9|GLYR1_MOUSE Putative oxidoreductase GLYR1 OS=Mus musculus GN=Glyr1
PE=2 SV=1
Length = 546
Score = 179 bits (452), Expect = 5e-044
Identities = 94/216 (43%), Positives = 138/216 (63%)
Frame = +2
Query: 362 KVQSMLPVGKNGAVSGISSGKGYVDVSTVDAASSVLISKQIKDTGALFLEAPVSGSKKPA 541
K L +G +G + GI GK YVD+STVDA + +++ I G FLEAPVSG+++ +
Sbjct: 328 KAAKDLVLGPSGVLQGIRPGKCYVDMSTVDADTVTELAQVIVSRGGRFLEAPVSGNQQLS 387
Query: 542 EDGQLIFLTAGDKLLYEKAAPFLDIMGKSRFYLGDVGNGAAMKLVVNMIMGSMMASFAEG 721
DG L+ L AGD+ LYE + MGK+ F+LG+VGN A M L+VNM+ GS MA+ AEG
Sbjct: 388 NDGMLVILAAGDRGLYEDCSSCFQAMGKTSFFLGEVGNAAKMMLIVNMVQGSFMATIAEG 447
Query: 722 ILLSQKVGLDPNVLVEVVSQGAINAPMYSLKGPSMIKSVYPTAFPLKHHQKDMRLALGLA 901
+ L+Q G L+++++QG + + K ++++ + F LK+ QKD+RLA+ L
Sbjct: 448 LTLAQVTGQSQQTLLDILNQGQLASIFLDQKCQNILQGNFKPDFYLKYIQKDLRLAIALG 507
Query: 902 ESVSQSTPIAAAANELYKVAKSYGLSDEDFFAVIEA 1009
++V+ TP+AAAANE+YK AK+ SD D AV A
Sbjct: 508 DAVNHPTPMAAAANEVYKRAKALDQSDNDMSAVYRA 543
>sp|Q5RKH0|GLYR1_RAT Putative oxidoreductase GLYR1 OS=Rattus norvegicus GN=Glyr1
PE=2 SV=1
Length = 552
Score = 179 bits (452), Expect = 5e-044
Identities = 94/216 (43%), Positives = 138/216 (63%)
Frame = +2
Query: 362 KVQSMLPVGKNGAVSGISSGKGYVDVSTVDAASSVLISKQIKDTGALFLEAPVSGSKKPA 541
K L +G +G + GI GK YVD+STVDA + +++ I G FLEAPVSG+++ +
Sbjct: 334 KAAKDLVLGPSGVLQGIRPGKCYVDMSTVDADTVTELAQVIVSRGGRFLEAPVSGNQQLS 393
Query: 542 EDGQLIFLTAGDKLLYEKAAPFLDIMGKSRFYLGDVGNGAAMKLVVNMIMGSMMASFAEG 721
DG L+ L AGD+ LYE + MGK+ F+LG+VGN A M L+VNM+ GS MA+ AEG
Sbjct: 394 NDGMLVILAAGDRGLYEDCSSCFQAMGKTSFFLGEVGNAAKMMLIVNMVQGSFMATIAEG 453
Query: 722 ILLSQKVGLDPNVLVEVVSQGAINAPMYSLKGPSMIKSVYPTAFPLKHHQKDMRLALGLA 901
+ L+Q G L+++++QG + + K ++++ + F LK+ QKD+RLA+ L
Sbjct: 454 LTLAQVTGQSQQTLLDILNQGQLASIFLDQKCQNILQGNFKPDFYLKYIQKDLRLAIALG 513
Query: 902 ESVSQSTPIAAAANELYKVAKSYGLSDEDFFAVIEA 1009
++V+ TP+AAAANE+YK AK+ SD D AV A
Sbjct: 514 DAVNHPTPMAAAANEVYKRAKALDQSDNDMSAVYRA 549
>sp|Q49A26|GLYR1_HUMAN Putative oxidoreductase GLYR1 OS=Homo sapiens GN=GLYR1
PE=1 SV=3
Length = 553
Score = 177 bits (447), Expect = 2e-043
Identities = 93/216 (43%), Positives = 137/216 (63%)
Frame = +2
Query: 362 KVQSMLPVGKNGAVSGISSGKGYVDVSTVDAASSVLISKQIKDTGALFLEAPVSGSKKPA 541
K L +G +G + GI GK YVD+STVDA + +++ I G FLEAPVSG+++ +
Sbjct: 335 KAAKDLVLGPSGVLQGIRPGKCYVDMSTVDADTVTELAQVIVSRGGRFLEAPVSGNQQLS 394
Query: 542 EDGQLIFLTAGDKLLYEKAAPFLDIMGKSRFYLGDVGNGAAMKLVVNMIMGSMMASFAEG 721
DG L+ L AGD+ LYE + MGK+ F+LG+VGN A M L+VNM+ GS MA+ AEG
Sbjct: 395 NDGMLVILAAGDRGLYEDCSSCFQAMGKTSFFLGEVGNAAKMMLIVNMVQGSFMATIAEG 454
Query: 722 ILLSQKVGLDPNVLVEVVSQGAINAPMYSLKGPSMIKSVYPTAFPLKHHQKDMRLALGLA 901
+ L+ G L+++++QG + + K ++++ + F LK+ QKD+RLA+ L
Sbjct: 455 LTLAHVTGQSQQTLLDILNQGQLASIFLDQKCQNILQGNFKPDFYLKYIQKDLRLAIALG 514
Query: 902 ESVSQSTPIAAAANELYKVAKSYGLSDEDFFAVIEA 1009
++V+ TP+AAAANE+YK AK+ SD D AV A
Sbjct: 515 DAVNHPTPMAAAANEVYKRAKALDQSDNDMSAVYRA 550
>sp|Q5R7T2|GLYR1_PONAB Putative oxidoreductase GLYR1 OS=Pongo abelii GN=GLYR1
PE=2 SV=2
Length = 553
Score = 176 bits (444), Expect = 5e-043
Identities = 93/216 (43%), Positives = 137/216 (63%)
Frame = +2
Query: 362 KVQSMLPVGKNGAVSGISSGKGYVDVSTVDAASSVLISKQIKDTGALFLEAPVSGSKKPA 541
K L +G +G + GI K YVD+STVDA + +++ I G FLEAPVSG+++ +
Sbjct: 335 KAAKDLVLGPSGVLQGIRPRKCYVDMSTVDADTVTELAQVIVSRGGRFLEAPVSGNQQLS 394
Query: 542 EDGQLIFLTAGDKLLYEKAAPFLDIMGKSRFYLGDVGNGAAMKLVVNMIMGSMMASFAEG 721
DG L+ L AGD+ LYE + MGK+ F+LG+VGN A M L+VNM+ GS MA+ AEG
Sbjct: 395 NDGMLVILAAGDRGLYEDCSSCFQAMGKTSFFLGEVGNAAKMMLIVNMVQGSFMATIAEG 454
Query: 722 ILLSQKVGLDPNVLVEVVSQGAINAPMYSLKGPSMIKSVYPTAFPLKHHQKDMRLALGLA 901
+ L+Q G L+++++QG + + K ++++ + F LK+ QKD+RLA+ L
Sbjct: 455 LTLAQVTGQSQQTLLDILNQGQLASIFLDQKCQNILQGNFKPDFYLKYIQKDLRLAIALG 514
Query: 902 ESVSQSTPIAAAANELYKVAKSYGLSDEDFFAVIEA 1009
++V+ TP+AAAANE+YK AK+ SD D AV A
Sbjct: 515 DAVNHPTPMAAAANEVYKRAKALDQSDNDMSAVYRA 550
>sp|Q562D5|GLYR1_XENTR Putative oxidoreductase GLYR1 OS=Xenopus tropicalis
GN=glyr1 PE=2 SV=1
Length = 534
Score = 174 bits (439), Expect = 2e-042
Identities = 92/216 (42%), Positives = 137/216 (63%)
Frame = +2
Query: 362 KVQSMLPVGKNGAVSGISSGKGYVDVSTVDAASSVLISKQIKDTGALFLEAPVSGSKKPA 541
K L +G +G + GI GK YVD+STVD + +++ I G FLEAPVSG+++ +
Sbjct: 316 KAAKDLVLGPSGVLQGIRPGKCYVDMSTVDPETVAELAQVIVSRGGRFLEAPVSGNQQLS 375
Query: 542 EDGQLIFLTAGDKLLYEKAAPFLDIMGKSRFYLGDVGNGAAMKLVVNMIMGSMMASFAEG 721
DG L+ L AGD+ +YE + MGK+ F+LG+VGN A M L++NM+ GS MA+ AEG
Sbjct: 376 NDGMLVILAAGDQGVYEDCSSCFLAMGKTSFFLGEVGNAARMMLILNMVQGSFMATIAEG 435
Query: 722 ILLSQKVGLDPNVLVEVVSQGAINAPMYSLKGPSMIKSVYPTAFPLKHHQKDMRLALGLA 901
+ L+Q G L+++++QG + + K ++++ + F LK+ QKD+RLA+ L
Sbjct: 436 MTLAQVTGQSQQTLLDILNQGQLASIFLDQKCQNILQGNFKPDFYLKYIQKDLRLAIALG 495
Query: 902 ESVSQSTPIAAAANELYKVAKSYGLSDEDFFAVIEA 1009
+SV+ TP+AAAANE+YK AK+ SD D AV A
Sbjct: 496 DSVNHPTPMAAAANEVYKRAKALDQSDNDMSAVYRA 531
>sp|Q5RKN4|GLYR1_DANRE Putative oxidoreductase GLYR1 OS=Danio rerio GN=glyr1
PE=2 SV=1
Length = 462
Score = 168 bits (425), Expect = 7e-041
Identities = 87/212 (41%), Positives = 133/212 (62%), Gaps = 1/212 (0%)
Frame = +2
Query: 377 LPVGKNGAVSGISSGKGYVDVSTVDAASSVLISKQIKDTGALFLEAPVSGSKKPAEDGQL 556
L +G +G + GI GK YV++STVD + +S+ I G FLEAPVSGS++ + DG L
Sbjct: 248 LVLGPSGVLQGIRPGKCYVEMSTVDPETITELSQVITSRGGRFLEAPVSGSQQLSNDGML 307
Query: 557 IFLTAGDKLLYEKAAPFLDIMGKSRFYL-GDVGNGAAMKLVVNMIMGSMMASFAEGILLS 733
+ + AGD+ +YE + MGK+ F++ G+ GN A M L++NM+ GS MA+ AEG+ L+
Sbjct: 308 VIVAAGDRSVYEDCSSCFQAMGKTSFFIAGEAGNAARMMLILNMVQGSFMATIAEGLTLA 367
Query: 734 QKVGLDPNVLVEVVSQGAINAPMYSLKGPSMIKSVYPTAFPLKHHQKDMRLALGLAESVS 913
Q G ++++ QG + + K ++++ + + LKH QKD+RLA+ + +SV+
Sbjct: 368 QATGQSQQTFLDILCQGQMASTFVDQKCQNILQGNFKPDYYLKHIQKDLRLAISMGDSVN 427
Query: 914 QSTPIAAAANELYKVAKSYGLSDEDFFAVIEA 1009
TP+AAAANE+YK AK+ SD D AV A
Sbjct: 428 HPTPMAAAANEVYKRAKALDQSDNDMSAVYRA 459
>sp|Q175F8|GLYR1_AEDAE Putative oxidoreductase GLYR1 homolog OS=Aedes aegypti
GN=AAEL006684 PE=3 SV=1
Length = 559
Score = 164 bits (414), Expect = 1e-039
Identities = 88/213 (41%), Positives = 130/213 (61%)
Frame = +2
Query: 362 KVQSMLPVGKNGAVSGISSGKGYVDVSTVDAASSVLISKQIKDTGALFLEAPVSGSKKPA 541
+V L G G +S GKGYV+++ VD +S I++QI G +LEA + GSK A
Sbjct: 341 QVAKELVFGNCGVMSANLVGKGYVEMTGVDPETSHDIAEQIIAKGGRYLEAQIQGSKNQA 400
Query: 542 EDGQLIFLTAGDKLLYEKAAPFLDIMGKSRFYLGDVGNGAAMKLVVNMIMGSMMASFAEG 721
E+G LI L AG++LL+E+ + + ++ FY+GDVGN M LV+ MI G M+A AEG
Sbjct: 401 EEGTLIILAAGERLLFEECQTCFEAISRNSFYMGDVGNATKMNLVLQMISGVMLAGIAEG 460
Query: 722 ILLSQKVGLDPNVLVEVVSQGAINAPMYSLKGPSMIKSVYPTAFPLKHHQKDMRLALGLA 901
+ L+ + GL ++EV+ ++++ + KG ++IK +P LKH QKD++LAL +A
Sbjct: 461 LALADRAGLQQKDVLEVLELTSMSSELVMQKGNAIIKGEFPPQQALKHMQKDLKLALNMA 520
Query: 902 ESVSQSTPIAAAANELYKVAKSYGLSDEDFFAV 1000
E + Q PI AA+NE+YK AK G D AV
Sbjct: 521 EGLEQPLPITAASNEVYKHAKRLGYGSHDSSAV 553
>sp|Q7Q161|GLYR1_ANOGA Putative oxidoreductase GLYR1 homolog OS=Anopheles
gambiae GN=AGAP009949 PE=3 SV=5
Length = 566
Score = 162 bits (408), Expect = 7e-039
Identities = 86/205 (41%), Positives = 126/205 (61%)
Frame = +2
Query: 386 GKNGAVSGISSGKGYVDVSTVDAASSVLISKQIKDTGALFLEAPVSGSKKPAEDGQLIFL 565
G G +S +GKGYV+++ VD +S I++ I G +LEA + GSK AE+G LI L
Sbjct: 356 GNCGVMSANLAGKGYVEMTGVDPETSNDINEAIISKGGRYLEAQIQGSKNQAEEGTLIIL 415
Query: 566 TAGDKLLYEKAAPFLDIMGKSRFYLGDVGNGAAMKLVVNMIMGSMMASFAEGILLSQKVG 745
+GD+LL+E+ + + ++ FYLGDVGN M L++ MI G +A AE + L+ + G
Sbjct: 416 ASGDRLLFEECQSCFEAISRNSFYLGDVGNATKMNLILQMISGITLAGVAEAMALADRAG 475
Query: 746 LDPNVLVEVVSQGAINAPMYSLKGPSMIKSVYPTAFPLKHHQKDMRLALGLAESVSQSTP 925
L ++EV+ +++ M KG ++IK +PT LKH QKD++LAL LA+ + QS P
Sbjct: 476 LQQKDVLEVLELTNMSSEMMLQKGNAIIKGEFPTHHALKHMQKDLKLALSLADGLEQSLP 535
Query: 926 IAAAANELYKVAKSYGLSDEDFFAV 1000
I AA+NE+YK AK G D AV
Sbjct: 536 ITAASNEVYKHAKRLGYGSHDASAV 560
>sp|Q29NG1|GLYR1_DROPS Putative oxidoreductase GLYR1 homolog OS=Drosophila
pseudoobscura pseudoobscura GN=GA18401 PE=3 SV=2
Length = 612
Score = 132 bits (330), Expect = 8e-030
Identities = 65/193 (33%), Positives = 109/193 (56%)
Frame = +2
Query: 422 KGYVDVSTVDAASSVLISKQIKDTGALFLEAPVSGSKKPAEDGQLIFLTAGDKLLYEKAA 601
K YV++STVD +S+ I + IK +LEA + GS++ A DG LI L GD+ ++E+
Sbjct: 414 KAYVEMSTVDPDTSLDIGEGIKQCNGRYLEAQIHGSRQEAADGMLIILAGGDRTVFEECH 473
Query: 602 PFLDIMGKSRFYLGDVGNGAAMKLVVNMIMGSMMASFAEGILLSQKVGLDPNVLVEVVSQ 781
+ K+ F+LG+VGN + L++ I + AE + L+ + + N ++++
Sbjct: 474 SCFKTIAKNTFFLGNVGNACKVNLILQTIQAVSLVGLAEALALADRFSISLNDIIDIFDL 533
Query: 782 GAINAPMYSLKGPSMIKSVYPTAFPLKHHQKDMRLALGLAESVSQSTPIAAAANELYKVA 961
++ +P+ KG M K + PL H Q+D+RL L +AE++ QS P+ + NE++K
Sbjct: 534 TSMKSPLLLAKGKEMAKGDFNPQQPLSHMQRDLRLVLNMAENLDQSMPVTSITNEVFKHT 593
Query: 962 KSYGLSDEDFFAV 1000
K G S+ D AV
Sbjct: 594 KRLGYSEHDSSAV 606
>sp|P77161|GLXR_ECOLI 2-hydroxy-3-oxopropionate reductase OS=Escherichia coli
(strain K12) GN=glxR PE=2 SV=1
Length = 292
Score = 116 bits (290), Expect = 3e-025
Identities = 60/210 (28%), Positives = 113/210 (53%)
Frame = +2
Query: 386 GKNGAVSGISSGKGYVDVSTVDAASSVLISKQIKDTGALFLEAPVSGSKKPAEDGQLIFL 565
G+NG GK VD+S++ + ++Q+ + G +L+APVSG + A +G L +
Sbjct: 75 GENGCTKASLKGKTIVDMSSISPIETKRFARQVNELGGDYLDAPVSGGEIGAREGTLSIM 134
Query: 566 TAGDKLLYEKAAPFLDIMGKSRFYLGDVGNGAAMKLVVNMIMGSMMASFAEGILLSQKVG 745
GD+ ++E+ P +++GK+ +G G+G K+ +I+ + + +E +L + K G
Sbjct: 135 VGGDEAVFERVKPLFELLGKNITLVGGNGDGQTCKVANQIIVALNIEAVSEALLFASKAG 194
Query: 746 LDPNVLVEVVSQGAINAPMYSLKGPSMIKSVYPTAFPLKHHQKDMRLALGLAESVSQSTP 925
DP + + + G ++ + + G MIK + F + HQKD+ LAL A++++ + P
Sbjct: 195 ADPVRVRQALMGGFASSRILEVHGERMIKRTFNPGFKIALHQKDLNLALQSAKALALNLP 254
Query: 926 IAAAANELYKVAKSYGLSDEDFFAVIEALK 1015
A EL+ + G S D A+++AL+
Sbjct: 255 NTATCQELFNTCAANGGSQLDHSALVQALE 284
>sp|P0ABQ3|GARR_ECOL6 2-hydroxy-3-oxopropionate reductase OS=Escherichia coli O6
GN=garR PE=3 SV=1
Length = 294
Score = 107 bits (266), Expect = 2e-022
Identities = 58/206 (28%), Positives = 106/206 (51%)
Frame = +2
Query: 383 VGKNGAVSGISSGKGYVDVSTVDAASSVLISKQIKDTGALFLEAPVSGSKKPAEDGQLIF 562
+G+NG + G G +D+S++ +S IS+ +K G L+APVSG + A DG L
Sbjct: 75 LGENGIIEGAKPGTVLIDMSSIAPLASREISEALKAKGIDMLDAPVSGGEPKAIDGTLSV 134
Query: 563 LTAGDKLLYEKAAPFLDIMGKSRFYLGDVGNGAAMKLVVNMIMGSMMASFAEGILLSQKV 742
+ GDK +++K + M S + G++G G KL +I+ +A+ +E + L+ K
Sbjct: 135 MVGGDKAIFDKYYDLMKAMAGSVVHTGEIGAGNVTKLANQVIVALNIAAMSEALTLATKA 194
Query: 743 GLDPNVLVEVVSQGAINAPMYSLKGPSMIKSVYPTAFPLKHHQKDMRLALGLAESVSQST 922
G++P+++ + + G + + K P ++ + F + H KD+ AL + V
Sbjct: 195 GVNPDLVYQAIRGGLAGSTVLDAKAPMVMDRNFKPGFRIDLHIKDLANALDTSHGVGAQL 254
Query: 923 PIAAAANELYKVAKSYGLSDEDFFAV 1000
P+ AA E+ + ++ GL D A+
Sbjct: 255 PLTAAVMEMMQALRADGLGTADHSAL 280
>sp|P0ABQ2|GARR_ECOLI 2-hydroxy-3-oxopropionate reductase OS=Escherichia coli
(strain K12) GN=garR PE=1 SV=1
Length = 294
Score = 107 bits (266), Expect = 2e-022
Identities = 58/206 (28%), Positives = 106/206 (51%)
Frame = +2
Query: 383 VGKNGAVSGISSGKGYVDVSTVDAASSVLISKQIKDTGALFLEAPVSGSKKPAEDGQLIF 562
+G+NG + G G +D+S++ +S IS+ +K G L+APVSG + A DG L
Sbjct: 75 LGENGIIEGAKPGTVLIDMSSIAPLASREISEALKAKGIDMLDAPVSGGEPKAIDGTLSV 134
Query: 563 LTAGDKLLYEKAAPFLDIMGKSRFYLGDVGNGAAMKLVVNMIMGSMMASFAEGILLSQKV 742
+ GDK +++K + M S + G++G G KL +I+ +A+ +E + L+ K
Sbjct: 135 MVGGDKAIFDKYYDLMKAMAGSVVHTGEIGAGNVTKLANQVIVALNIAAMSEALTLATKA 194
Query: 743 GLDPNVLVEVVSQGAINAPMYSLKGPSMIKSVYPTAFPLKHHQKDMRLALGLAESVSQST 922
G++P+++ + + G + + K P ++ + F + H KD+ AL + V
Sbjct: 195 GVNPDLVYQAIRGGLAGSTVLDAKAPMVMDRNFKPGFRIDLHIKDLANALDTSHGVGAQL 254
Query: 923 PIAAAANELYKVAKSYGLSDEDFFAV 1000
P+ AA E+ + ++ GL D A+
Sbjct: 255 PLTAAVMEMMQALRADGLGTADHSAL 280
>sp|P28811|MMSB_PSEAE 3-hydroxyisobutyrate dehydrogenase OS=Pseudomonas
aeruginosa GN=mmsB PE=2 SV=1
Length = 298
Score = 102 bits (253), Expect = 7e-021
Identities = 76/235 (32%), Positives = 119/235 (50%), Gaps = 17/235 (7%)
Frame = +2
Query: 305 LLKK*LQLAISHLQC*LILKVQ-SMLPVGK---------NGAVSGISSGKGYVDVSTVDA 454
L+++ Q A S LQC +V SMLP G+ +G ++ ++ +D ST+
Sbjct: 40 LVEQGAQGADSALQCCEGAEVVISMLPAGQHVESLYLGDDGLLARVAGKPLLIDCSTIAP 99
Query: 455 ASSVLISKQIKDTGALFLEAPVSGSKKPAEDGQLIFLTAGDKLLYEKAAPFLDIMGKSRF 634
++ +++ G L+APVSG A G L F+ G + +A P L+ MG++ F
Sbjct: 100 ETARKVAEAAAAKGLTLLDAPVSGGVGGARAGTLSFIVGGPAEGFARARPVLENMGRNIF 159
Query: 635 YLGDVGNGAAMKLVVNMIMGSMMASFAEGILLSQKVGLDPNVLVEVVSQG-----AINA- 796
+ GD G G K+ NM++G +MA AE + L K GLDP VL EV+ Q A+N
Sbjct: 160 HAGDHGAGQVAKICNNMLLGILMAGTAEALALGVKNGLDPAVLSEVMKQSSGGNWALNLY 219
Query: 797 -PMYSLKGPSMIKSVYPTAFPLKHHQKDMRLALGLAESVSQSTPIAAAANELYKV 958
P + + + Y F ++ KD+ LAL A++V STP+ A A L+ +
Sbjct: 220 NPWPGVMPQAPASNGYAGGFQVRLMNKDLGLALANAQAVQASTPLGALARNLFSL 274
>sp|P31937|3HIDH_HUMAN 3-hydroxyisobutyrate dehydrogenase, mitochondrial OS=Homo
sapiens GN=HIBADH PE=1 SV=2
Length = 336
Score = 102 bits (252), Expect = 9e-021
Identities = 63/217 (29%), Positives = 107/217 (49%), Gaps = 7/217 (3%)
Frame = +2
Query: 386 GKNGAVSGISSGKGYVDVSTVDAASSVLISKQIKDTGALFLEAPVSGSKKPAEDGQLIFL 565
G NG + + G +D ST+D A S ++K+++ GA+F++APVSG A G L F+
Sbjct: 115 GANGILKKVKKGSLLIDSSTIDPAVSKELAKEVEKMGAVFMDAPVSGGVGAARSGNLTFM 174
Query: 566 TAGDKLLYEKAAPFLDIMGKSRFYLGDVGNGAAMKLVVNMIMGSMMASFAEGILLSQKVG 745
G + + A L MG + Y G VG G A K+ NM++ M AE + L ++G
Sbjct: 175 VGGVEDEFAAAQELLGCMGSNVVYCGAVGTGQAAKICNNMLLAISMIGTAEAMNLGIRLG 234
Query: 746 LDPNVLVEVVSQGAINA-------PMYSLKGPSMIKSVYPTAFPLKHHQKDMRLALGLAE 904
LDP +L ++++ + P+ + + Y F KD+ LA A
Sbjct: 235 LDPKLLAKILNMSSGRCWSSDTYNPVPGVMDGVPSANNYQGGFGTTLMAKDLGLAQDSAT 294
Query: 905 SVSQSTPIAAAANELYKVAKSYGLSDEDFFAVIEALK 1015
S + + A+++Y++ + G S +DF +V + L+
Sbjct: 295 STKSPILLGSLAHQIYRMMCAKGYSKKDFSSVFQFLR 331
>sp|Q5R5E7|3HIDH_PONAB 3-hydroxyisobutyrate dehydrogenase, mitochondrial
OS=Pongo abelii GN=HIBADH PE=2 SV=1
Length = 336
Score = 102 bits (252), Expect = 9e-021
Identities = 63/217 (29%), Positives = 107/217 (49%), Gaps = 7/217 (3%)
Frame = +2
Query: 386 GKNGAVSGISSGKGYVDVSTVDAASSVLISKQIKDTGALFLEAPVSGSKKPAEDGQLIFL 565
G NG + + G +D ST+D A S ++K+++ GA+F++APVSG A G L F+
Sbjct: 115 GANGILKKVKKGSLLIDSSTIDPAVSKELAKEVEKMGAVFMDAPVSGGVGAARSGNLTFM 174
Query: 566 TAGDKLLYEKAAPFLDIMGKSRFYLGDVGNGAAMKLVVNMIMGSMMASFAEGILLSQKVG 745
G + + A L MG + Y G VG G A K+ NM++ M AE + L ++G
Sbjct: 175 VGGVEDEFAAAQELLGCMGSNVVYCGAVGTGQAAKICNNMLLAISMIGTAEAMNLGIRLG 234
Query: 746 LDPNVLVEVVSQGAINA-------PMYSLKGPSMIKSVYPTAFPLKHHQKDMRLALGLAE 904
LDP +L ++++ + P+ + + Y F KD+ LA A
Sbjct: 235 LDPKLLAKILNMSSGRCWSSDTYNPVPGVMDGVPSANNYQGGFGATLMAKDLGLAQDSAT 294
Query: 905 SVSQSTPIAAAANELYKVAKSYGLSDEDFFAVIEALK 1015
S + + A+++Y++ + G S +DF +V + L+
Sbjct: 295 STKSPILLGSLAHQIYRMMCAKGYSKKDFSSVFQFLR 331
>sp|P29266|3HIDH_RAT 3-hydroxyisobutyrate dehydrogenase, mitochondrial OS=Rattus
norvegicus GN=Hibadh PE=1 SV=3
Length = 335
Score = 101 bits (250), Expect = 1e-020
Identities = 62/217 (28%), Positives = 107/217 (49%), Gaps = 7/217 (3%)
Frame = +2
Query: 386 GKNGAVSGISSGKGYVDVSTVDAASSVLISKQIKDTGALFLEAPVSGSKKPAEDGQLIFL 565
G NG + + G +D ST+D + S ++K+++ GA+F++APVSG A G L F+
Sbjct: 114 GANGILKKVKKGSLLIDSSTIDPSVSKELAKEVEKMGAVFMDAPVSGGVGAARSGNLTFM 173
Query: 566 TAGDKLLYEKAAPFLDIMGKSRFYLGDVGNGAAMKLVVNMIMGSMMASFAEGILLSQKVG 745
G + + A L MG + Y G VG+G + K+ NM++ M AE + L + G
Sbjct: 174 VGGVENEFAAAQELLGCMGSNVLYCGAVGSGQSAKICNNMLLAISMIGTAEAMNLGIRSG 233
Query: 746 LDPNVLVEVVSQGAINA-------PMYSLKGPSMIKSVYPTAFPLKHHQKDMRLALGLAE 904
LDP +L ++++ + P+ + + Y F KD+ LA A
Sbjct: 234 LDPKLLAKILNMSSGRCWSSDTYNPVPGVMDGVPSSNNYQGGFGTTLMAKDLGLAQDSAT 293
Query: 905 SVSQSTPIAAAANELYKVAKSYGLSDEDFFAVIEALK 1015
S + + A+++Y++ S G S +DF +V + L+
Sbjct: 294 STKTPILLGSVAHQIYRMMCSKGYSKKDFSSVFQYLR 330
>sp|Q99L13|3HIDH_MOUSE 3-hydroxyisobutyrate dehydrogenase, mitochondrial OS=Mus
musculus GN=Hibadh PE=2 SV=1
Length = 335
Score = 100 bits (248), Expect = 2e-020
Identities = 62/217 (28%), Positives = 107/217 (49%), Gaps = 7/217 (3%)
Frame = +2
Query: 386 GKNGAVSGISSGKGYVDVSTVDAASSVLISKQIKDTGALFLEAPVSGSKKPAEDGQLIFL 565
G NG + + G +D ST+D + S ++K+++ GA+F++APVSG A G L F+
Sbjct: 114 GANGILKKVKKGSLLIDSSTIDPSVSKELAKEVEKMGAVFMDAPVSGGVGAARSGNLTFM 173
Query: 566 TAGDKLLYEKAAPFLDIMGKSRFYLGDVGNGAAMKLVVNMIMGSMMASFAEGILLSQKVG 745
G + + A L+ MG + Y G VG G + K+ NM++ M AE + L + G
Sbjct: 174 VGGVEDEFAAAQELLECMGSNVVYCGAVGTGQSAKICNNMLLAISMIGTAEAMNLGIRSG 233
Query: 746 LDPNVLVEVVSQGAINA-------PMYSLKGPSMIKSVYPTAFPLKHHQKDMRLALGLAE 904
LDP +L ++++ + P+ + + Y F KD+ LA A
Sbjct: 234 LDPKLLAKILNMSSGRCWSSDTYNPVPGVMHGVPSSNNYQGGFGTTLMAKDLGLAQDSAT 293
Query: 905 SVSQSTPIAAAANELYKVAKSYGLSDEDFFAVIEALK 1015
S + + A+++Y++ S G S +DF +V + L+
Sbjct: 294 STKTPILLGSLAHQIYRMMCSKGYSKKDFSSVFQYLR 330
>sp|Q2HJD7|3HIDH_BOVIN 3-hydroxyisobutyrate dehydrogenase, mitochondrial OS=Bos
taurus GN=HIBADH PE=2 SV=1
Length = 336
Score = 99 bits (245), Expect = 6e-020
Identities = 61/217 (28%), Positives = 106/217 (48%), Gaps = 7/217 (3%)
Frame = +2
Query: 386 GKNGAVSGISSGKGYVDVSTVDAASSVLISKQIKDTGALFLEAPVSGSKKPAEDGQLIFL 565
G NG + + G +D ST+D S ++K+++ GA+F++APVSG A G L F+
Sbjct: 115 GANGILKKVKKGSLLIDSSTIDPMVSKELAKEVEKMGAVFMDAPVSGGVGAARSGNLTFM 174
Query: 566 TAGDKLLYEKAAPFLDIMGKSRFYLGDVGNGAAMKLVVNMIMGSMMASFAEGILLSQKVG 745
G + + A L MG + Y G VG G A K+ N+++ M AE + L ++G
Sbjct: 175 VGGVEEEFAAAQELLGCMGSNVVYCGAVGTGQAAKICNNLLLAISMIGTAEAMNLGIRLG 234
Query: 746 LDPNVLVEVVSQGAINA-------PMYSLKGPSMIKSVYPTAFPLKHHQKDMRLALGLAE 904
LDP +L ++++ + P+ + + Y F KD+ LA A
Sbjct: 235 LDPKLLAKILNMSSGRCWSSDTYNPVPGVMDGVPSANNYQGGFGTTLMAKDLGLAQDSAT 294
Query: 905 SVSQSTPIAAAANELYKVAKSYGLSDEDFFAVIEALK 1015
S + + A+++Y++ + G S +DF +V + L+
Sbjct: 295 STKSPILLGSQAHQIYRMMCAKGYSKKDFSSVFQFLR 331
Database: UniProt/SwissProt
Posted date: Sat Aug 07 14:36:18 2010
Number of letters in database: 182,829,261
Number of sequences in database: 518,415
Lambda K H
0.267 0.041 0.140
Gapped
Lambda K H
0.267 0.041 0.140
Matrix: blosum62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 187,161,879,332
Number of Sequences: 518415
Number of Extensions: 187161879332
Number of Successful Extensions: 1147171164
Number of sequences better than 0.0: 0
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