BLASTX 7.6.2
Query= UN50386 /QuerySize=1135
(1134 letters)
Database: UniProt/SwissProt;
518,415 sequences; 182,829,261 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q2MHE4|HT1_ARATH Serine/threonine-protein kinase HT1 OS=Arabi... 148 1e-034
sp|Q9ESL4|MLTK_MOUSE Mitogen-activated protein kinase kinase kin... 119 5e-026
sp|Q05609|CTR1_ARATH Serine/threonine-protein kinase CTR1 OS=Ara... 119 6e-026
sp|Q9NYL2|MLTK_HUMAN Mitogen-activated protein kinase kinase kin... 119 6e-026
sp|Q54H45|DRKB_DICDI Probable serine/threonine-protein kinase dr... 117 2e-025
sp|Q16584|M3K11_HUMAN Mitogen-activated protein kinase kinase ki... 116 3e-025
sp|Q80XI6|M3K11_MOUSE Mitogen-activated protein kinase kinase ki... 116 3e-025
sp|Q66HA1|M3K11_RAT Mitogen-activated protein kinase kinase kina... 116 3e-025
sp|Q66L42|M3K10_MOUSE Mitogen-activated protein kinase kinase ki... 114 1e-024
sp|Q02779|M3K10_HUMAN Mitogen-activated protein kinase kinase ki... 114 2e-024
sp|Q7T2V3|M3K10_XENLA Mitogen-activated protein kinase kinase ki... 112 4e-024
sp|P80192|M3K9_HUMAN Mitogen-activated protein kinase kinase kin... 112 7e-024
sp|Q12852|M3K12_HUMAN Mitogen-activated protein kinase kinase ki... 110 2e-023
sp|Q60700|M3K12_MOUSE Mitogen-activated protein kinase kinase ki... 110 2e-023
sp|Q3U1V8|M3K9_MOUSE Mitogen-activated protein kinase kinase kin... 110 2e-023
sp|Q63796|M3K12_RAT Mitogen-activated protein kinase kinase kina... 110 3e-023
sp|Q8VDG6|M3KL4_MOUSE Mitogen-activated protein kinase kinase ki... 110 3e-023
sp|Q5TCX8|M3KL4_HUMAN Mitogen-activated protein kinase kinase ki... 109 5e-023
sp|Q23915|KINX_DICDI Probable serine/threonine-protein kinase ki... 108 1e-022
sp|A8X775|DLK1_CAEBR Mitogen-activated protein kinase kinase kin... 100 3e-020
>sp|Q2MHE4|HT1_ARATH Serine/threonine-protein kinase HT1 OS=Arabidopsis thaliana
GN=HT1 PE=1 SV=1
Length = 390
Score = 148 bits (371), Expect = 1e-034
Identities = 67/157 (42%), Positives = 105/157 (66%), Gaps = 1/157 (0%)
Frame = +2
Query: 365 IKDVIQLALDLARGLSYLHSKVIVHRYVKSENMLLEPNKTLKIADFGVARVEAQNPQDMT 544
I+ V++LALD++RG+ YLHS+ ++HR +KS N+LL +K+ADFG + +E Q ++
Sbjct: 186 IETVLRLALDISRGMEYLHSQGVIHRDLKSNNLLLNDEMRVKVADFGTSCLETQ-CREAK 244
Query: 545 GETGTLGYMAPEVLEGKAYNRKCDVYSFGVCLWEIYCCDMPYADCSFAEISHAVVHKNLR 724
G GT +MAPE+++ K Y RK DVYSFG+ LWE+ +P+ + + + AV KN R
Sbjct: 245 GNMGTYRWMAPEMIKEKPYTRKVDVYSFGIVLWELTTALLPFQGMTPVQAAFAVAEKNER 304
Query: 725 PEIPKCCPQSVANIMRRCWDPNPDKRPEMEEVVKLLE 835
P +P C ++A++++RCW NP KRP+ +V +LE
Sbjct: 305 PPLPASCQPALAHLIKRCWSENPSKRPDFSNIVAVLE 341
>sp|Q9ESL4|MLTK_MOUSE Mitogen-activated protein kinase kinase kinase MLT OS=Mus
musculus GN=Mltk PE=1 SV=1
Length = 802
Score = 119 bits (297), Expect = 5e-026
Identities = 55/163 (33%), Positives = 97/163 (59%), Gaps = 5/163 (3%)
Frame = +2
Query: 365 IKDVIQLALDLARGLSYLHSKV---IVHRYVKSENMLLEPNKTLKIADFGVARVEAQNPQ 535
++ ++ A D+A+G+ YLH + ++HR +KS N+++ + LKI DFG +R N
Sbjct: 104 MEHIMTWATDVAKGMHYLHMEAPVKVIHRDLKSRNVVIAADGVLKICDFGASRF--HNHT 161
Query: 536 DMTGETGTLGYMAPEVLEGKAYNRKCDVYSFGVCLWEIYCCDMPYADCSFAEISHAVVHK 715
GT +MAPEV++ + CD YS+GV LWE+ ++P+ +++ VV K
Sbjct: 162 THMSLVGTFPWMAPEVIQSLPVSETCDTYSYGVVLWEMLTREVPFKGLEGLQVAWLVVEK 221
Query: 716 NLRPEIPKCCPQSVANIMRRCWDPNPDKRPEMEEVVKLLEAVN 844
N R IP CP+S A ++ +CW+ + KRP ++++ +LE+++
Sbjct: 222 NERLTIPSSCPRSFAELLHQCWEADAKKRPSFKQIISILESMS 264
>sp|Q05609|CTR1_ARATH Serine/threonine-protein kinase CTR1 OS=Arabidopsis
thaliana GN=CTR1 PE=1 SV=1
Length = 821
Score = 119 bits (296), Expect = 6e-026
Identities = 72/200 (36%), Positives = 111/200 (55%), Gaps = 11/200 (5%)
Frame = +2
Query: 296 SLSMLLVAPSRSSLSRSIAPNSPIKDV-----IQLALDLARGLSYLHSK--VIVHRYVKS 454
+LS++ SR SL R + + + + + +A D+A+G++YLH++ IVHR +KS
Sbjct: 620 NLSIVTEYLSRGSLYRLLHKSGAREQLDERRRLSMAYDVAKGMNYLHNRNPPIVHRDLKS 679
Query: 455 ENMLLEPNKTLKIADFGVARVEAQNPQDMTGETGTLGYMAPEVLEGKAYNRKCDVYSFGV 634
N+L++ T+K+ DFG++R++A GT +MAPEVL + N K DVYSFGV
Sbjct: 680 PNLLVDKKYTVKVCDFGLSRLKASTFLSSKSAAGTPEWMAPEVLRDEPSNEKSDVYSFGV 739
Query: 635 CLWEIYCCDMPYADCSFAEISHAVVHKNLRPEIPKCCPQSVANIMRRCWDPNPDKRPEME 814
LWE+ P+ + + A++ AV K R EIP+ VA I+ CW P KRP
Sbjct: 740 ILWELATLQQPWGNLNPAQVVAAVGFKCKRLEIPRNLNPQVAAIIEGCWTNEPWKRPSFA 799
Query: 815 EVVKLLEAVNTSKGGGMIPP 874
++ LL + S +PP
Sbjct: 800 TIMDLLRPLIKS----AVPP 815
>sp|Q9NYL2|MLTK_HUMAN Mitogen-activated protein kinase kinase kinase MLT OS=Homo
sapiens GN=MLTK PE=1 SV=2
Length = 800
Score = 119 bits (296), Expect = 6e-026
Identities = 55/160 (34%), Positives = 95/160 (59%), Gaps = 5/160 (3%)
Frame = +2
Query: 374 VIQLALDLARGLSYLHSKV---IVHRYVKSENMLLEPNKTLKIADFGVARVEAQNPQDMT 544
++ A D+A+G+ YLH + ++HR +KS N+++ + LKI DFG +R N
Sbjct: 107 IMTWATDVAKGMHYLHMEAPVKVIHRDLKSRNVVIAADGVLKICDFGASRF--HNHTTHM 164
Query: 545 GETGTLGYMAPEVLEGKAYNRKCDVYSFGVCLWEIYCCDMPYADCSFAEISHAVVHKNLR 724
GT +MAPEV++ + CD YS+GV LWE+ ++P+ +++ VV KN R
Sbjct: 165 SLVGTFPWMAPEVIQSLPVSETCDTYSYGVVLWEMLTREVPFKGLEGLQVAWLVVEKNER 224
Query: 725 PEIPKCCPQSVANIMRRCWDPNPDKRPEMEEVVKLLEAVN 844
IP CP+S A ++ +CW+ + KRP ++++ +LE+++
Sbjct: 225 LTIPSSCPRSFAELLHQCWEADAKKRPSFKQIISILESMS 264
>sp|Q54H45|DRKB_DICDI Probable serine/threonine-protein kinase drkB
OS=Dictyostelium discoideum GN=drkB PE=3 SV=1
Length = 690
Score = 117 bits (291), Expect = 2e-025
Identities = 70/182 (38%), Positives = 105/182 (57%), Gaps = 9/182 (4%)
Frame = +2
Query: 344 SIAPNSPIKD----VIQLALDLARGLSYLH--SKVIVHRYVKSENMLLEPNKTLKIADFG 505
SI N IK V ++ +D A+G+ YLH + VI+HR +KS N+L++ N +K+ADFG
Sbjct: 475 SILHNEKIKISWSLVKRMMIDAAKGIIYLHGSTPVILHRDLKSHNLLVDENWKVKVADFG 534
Query: 506 VARVEAQNPQDMTGETGTLGYMAPEVLEGKAYNRKCDVYSFGVCLWEIYCCDMPYADCSF 685
++ +E Q MT GT + +PEVL + Y K DVYSFG+ LWE PY
Sbjct: 535 LSTIEQQG-ATMTA-CGTPCWTSPEVLRSQRYTEKADVYSFGIILWECATRQDPYFGIPP 592
Query: 686 AEISHAVVHKNLRPEIPKCCPQSVANIMRRCWDPNPDKRPEMEEVVKLLEAVNTSKGGGM 865
++ AV + +RP PK P +++ C + NP +RP ME+ +++LE++ T KG
Sbjct: 593 FQVIFAVGREGMRPPTPKYGPPKYIQLLKDCLNENPSQRPTMEQCLEILESIET-KGFDD 651
Query: 866 IP 871
IP
Sbjct: 652 IP 653
>sp|Q16584|M3K11_HUMAN Mitogen-activated protein kinase kinase kinase 11 OS=Homo
sapiens GN=MAP3K11 PE=1 SV=1
Length = 847
Score = 116 bits (290), Expect = 3e-025
Identities = 66/194 (34%), Positives = 109/194 (56%), Gaps = 14/194 (7%)
Frame = +2
Query: 296 SLSMLLVAPSRSSLSRSIAPNS-PIKDVIQLALDLARGLSYLHSKV---IVHRYVKSEN- 460
+L +++ + LSR++A P ++ A+ +ARG+ YLH + ++HR +KS N
Sbjct: 188 NLCLVMEYAAGGPLSRALAGRRVPPHVLVNWAVQIARGMHYLHCEALVPVIHRDLKSNNI 247
Query: 461 MLLEP-------NKTLKIADFGVARVEAQNPQDMTGETGTLGYMAPEVLEGKAYNRKCDV 619
+LL+P +KTLKI DFG+AR + Q GT +MAPEV++ +++ DV
Sbjct: 248 LLLQPIESDDMEHKTLKITDFGLAREWHKTTQ--MSAAGTYAWMAPEVIKASTFSKGSDV 305
Query: 620 YSFGVCLWEIYCCDMPYADCSFAEISHAVVHKNLRPEIPKCCPQSVANIMRRCWDPNPDK 799
+SFGV LWE+ ++PY +++ V L IP CP+ A +M CW +P +
Sbjct: 306 WSFGVLLWELLTGEVPYRGIDCLAVAYGVAVNKLTLPIPSTCPEPFAQLMADCWAQDPHR 365
Query: 800 RPEMEEVVKLLEAV 841
RP+ +++ LEA+
Sbjct: 366 RPDFASILQQLEAL 379
>sp|Q80XI6|M3K11_MOUSE Mitogen-activated protein kinase kinase kinase 11 OS=Mus
musculus GN=Map3k11 PE=1 SV=1
Length = 850
Score = 116 bits (290), Expect = 3e-025
Identities = 66/194 (34%), Positives = 109/194 (56%), Gaps = 14/194 (7%)
Frame = +2
Query: 296 SLSMLLVAPSRSSLSRSIAPNS-PIKDVIQLALDLARGLSYLHSKV---IVHRYVKSEN- 460
+L +++ + LSR++A P ++ A+ +ARG+ YLH + ++HR +KS N
Sbjct: 189 NLCLVMEYAAGGPLSRALAGRRVPPHVLVNWAVQIARGMHYLHCEALVPVIHRDLKSNNI 248
Query: 461 MLLEP-------NKTLKIADFGVARVEAQNPQDMTGETGTLGYMAPEVLEGKAYNRKCDV 619
+LL+P +KTLKI DFG+AR + Q GT +MAPEV++ +++ DV
Sbjct: 249 LLLQPIEGDDMEHKTLKITDFGLAREWHKTTQ--MSAAGTYAWMAPEVIKASTFSKGSDV 306
Query: 620 YSFGVCLWEIYCCDMPYADCSFAEISHAVVHKNLRPEIPKCCPQSVANIMRRCWDPNPDK 799
+SFGV LWE+ ++PY +++ V L IP CP+ A +M CW +P +
Sbjct: 307 WSFGVLLWELLTGEVPYRGIDCLAVAYGVAVNKLTLPIPSTCPEPFAQLMADCWAQDPHR 366
Query: 800 RPEMEEVVKLLEAV 841
RP+ +++ LEA+
Sbjct: 367 RPDFASILQQLEAL 380
>sp|Q66HA1|M3K11_RAT Mitogen-activated protein kinase kinase kinase 11 OS=Rattus
norvegicus GN=Map3k11 PE=2 SV=1
Length = 850
Score = 116 bits (290), Expect = 3e-025
Identities = 66/194 (34%), Positives = 109/194 (56%), Gaps = 14/194 (7%)
Frame = +2
Query: 296 SLSMLLVAPSRSSLSRSIAPNS-PIKDVIQLALDLARGLSYLHSKV---IVHRYVKSEN- 460
+L +++ + LSR++A P ++ A+ +ARG+ YLH + ++HR +KS N
Sbjct: 189 NLCLVMEYAAGGPLSRALAGRRVPPHVLVNWAVQIARGMHYLHCEALVPVIHRDLKSNNI 248
Query: 461 MLLEP-------NKTLKIADFGVARVEAQNPQDMTGETGTLGYMAPEVLEGKAYNRKCDV 619
+LL+P +KTLKI DFG+AR + Q GT +MAPEV++ +++ DV
Sbjct: 249 LLLQPIEGDDMEHKTLKITDFGLAREWHKTTQ--MSAAGTYAWMAPEVIKASTFSKGSDV 306
Query: 620 YSFGVCLWEIYCCDMPYADCSFAEISHAVVHKNLRPEIPKCCPQSVANIMRRCWDPNPDK 799
+SFGV LWE+ ++PY +++ V L IP CP+ A +M CW +P +
Sbjct: 307 WSFGVLLWELLTGEVPYRGIDCLAVAYGVAVNKLTLPIPSTCPEPFAQLMADCWAQDPHR 366
Query: 800 RPEMEEVVKLLEAV 841
RP+ +++ LEA+
Sbjct: 367 RPDFASILQQLEAL 380
>sp|Q66L42|M3K10_MOUSE Mitogen-activated protein kinase kinase kinase 10 OS=Mus
musculus GN=Map3k10 PE=2 SV=2
Length = 940
Score = 114 bits (284), Expect = 1e-024
Identities = 66/197 (33%), Positives = 107/197 (54%), Gaps = 14/197 (7%)
Frame = +2
Query: 296 SLSMLLVAPSRSSLSRSIAPNS-PIKDVIQLALDLARGLSYLHSKV---IVHRYVKSENM 463
+L +++ +LSR +A P ++ A+ +ARG++YLH+ I+HR +KS N+
Sbjct: 169 NLCLVMEYARGGALSRVLAGRRVPPHVLVNWAVQVARGMNYLHNDAPVPIIHRDLKSINI 228
Query: 464 LL--------EPNKTLKIADFGVARVEAQNPQDMTGETGTLGYMAPEVLEGKAYNRKCDV 619
L+ + LKI DFG+AR E M+ GT +MAPEV+ +++ DV
Sbjct: 229 LILEAIENHNLADTVLKITDFGLAR-EWHKTTKMSA-AGTYAWMAPEVIRLSLFSKSSDV 286
Query: 620 YSFGVCLWEIYCCDMPYADCSFAEISHAVVHKNLRPEIPKCCPQSVANIMRRCWDPNPDK 799
+SFGV LWE+ ++PY + +++ V L IP CP+ A ++ CWDP+P
Sbjct: 287 WSFGVLLWELLTGEVPYREIDALAVAYGVAMNKLTLPIPSTCPEPFARLLEECWDPDPHG 346
Query: 800 RPEMEEVVKLLEAVNTS 850
RP+ ++K LE + S
Sbjct: 347 RPDFGSILKQLEVIEQS 363
>sp|Q02779|M3K10_HUMAN Mitogen-activated protein kinase kinase kinase 10 OS=Homo
sapiens GN=MAP3K10 PE=1 SV=3
Length = 954
Score = 114 bits (283), Expect = 2e-024
Identities = 65/185 (35%), Positives = 102/185 (55%), Gaps = 14/185 (7%)
Frame = +2
Query: 332 SLSRSIAPNS-PIKDVIQLALDLARGLSYLHSKV---IVHRYVKSENMLL--------EP 475
+LSR +A P ++ A+ +ARG++YLH+ I+HR +KS N+L+
Sbjct: 181 ALSRVLAGRRVPPHVLVNWAVQVARGMNYLHNDAPVPIIHRDLKSINILILEAIENHNLA 240
Query: 476 NKTLKIADFGVARVEAQNPQDMTGETGTLGYMAPEVLEGKAYNRKCDVYSFGVCLWEIYC 655
+ LKI DFG+AR E M+ GT +MAPEV+ +++ DV+SFGV LWE+
Sbjct: 241 DTVLKITDFGLAR-EWHKTTKMSA-AGTYAWMAPEVIRLSLFSKSSDVWSFGVLLWELLT 298
Query: 656 CDMPYADCSFAEISHAVVHKNLRPEIPKCCPQSVANIMRRCWDPNPDKRPEMEEVVKLLE 835
++PY + +++ V L IP CP+ A ++ CWDP+P RP+ ++K LE
Sbjct: 299 GEVPYREIDALAVAYGVAMNKLTLPIPSTCPEPFARLLEECWDPDPHGRPDFGSILKRLE 358
Query: 836 AVNTS 850
+ S
Sbjct: 359 VIEQS 363
>sp|Q7T2V3|M3K10_XENLA Mitogen-activated protein kinase kinase kinase 10
OS=Xenopus laevis GN=map3k10 PE=1 SV=1
Length = 1005
Score = 112 bits (280), Expect = 4e-024
Identities = 64/184 (34%), Positives = 100/184 (54%), Gaps = 14/184 (7%)
Frame = +2
Query: 335 LSRSIAPNS-PIKDVIQLALDLARGLSYLHSKVIV---HRYVKSENMLLEP--------N 478
L R++A P ++ A+ +A+G++YLH++ IV HR + S N+L+ N
Sbjct: 202 LHRALAGKKVPAHVLVNWAVQIAKGMTYLHNEAIVPIIHRDLGSSNILILEKAENDDLFN 261
Query: 479 KTLKIADFGVARVEAQNPQDMTGETGTLGYMAPEVLEGKAYNRKCDVYSFGVCLWEIYCC 658
KTL I DFG+AR E Q M+ GT +MAPEV+ +++ DV+SFGV LWE+
Sbjct: 262 KTLNITDFGLAR-EWQKTTKMSA-AGTYAWMAPEVIRLSLFSKSSDVWSFGVLLWELLTG 319
Query: 659 DMPYADCSFAEISHAVVHKNLRPEIPKCCPQSVANIMRRCWDPNPDKRPEMEEVVKLLEA 838
++PY + +++ V L IP CP+ I+ CWDP+P RP +++ L
Sbjct: 320 EVPYREIDALAVAYGVAMNKLTLPIPSTCPEPFVRILEACWDPDPHSRPTFSCILEQLTT 379
Query: 839 VNTS 850
+ S
Sbjct: 380 IEQS 383
>sp|P80192|M3K9_HUMAN Mitogen-activated protein kinase kinase kinase 9 OS=Homo
sapiens GN=MAP3K9 PE=1 SV=3
Length = 1104
Score = 112 bits (278), Expect = 7e-024
Identities = 65/185 (35%), Positives = 99/185 (53%), Gaps = 15/185 (8%)
Frame = +2
Query: 374 VIQLALDLARGLSYLHSKVIV---HRYVKSENMLL--------EPNKTLKIADFGVARVE 520
++ A+ +ARG++YLH + IV HR +KS N+L+ NK LKI DFG+AR E
Sbjct: 242 LVNWAVQIARGMNYLHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAR-E 300
Query: 521 AQNPQDMTGETGTLGYMAPEVLEGKAYNRKCDVYSFGVCLWEIYCCDMPYADCSFAEISH 700
M+ GT +MAPEV+ +++ DV+S+GV LWE+ ++P+ +++
Sbjct: 301 WHRTTKMSA-AGTYAWMAPEVIRASMFSKGSDVWSYGVLLWELLTGEVPFRGIDGLAVAY 359
Query: 701 AVVHKNLRPEIPKCCPQSVANIMRRCWDPNPDKRPEMEEVVKLLEAVNTSKGGGMIPPDK 880
V L IP CP+ A +M CW+P+P RP ++ L + S G +P D
Sbjct: 360 GVAMNKLALPIPSTCPEPFAKLMEDCWNPDPHSRPSFTNILDQLTTIEES-GFFEMPKDS 418
Query: 881 FQGCL 895
F CL
Sbjct: 419 FH-CL 422
>sp|Q12852|M3K12_HUMAN Mitogen-activated protein kinase kinase kinase 12 OS=Homo
sapiens GN=MAP3K12 PE=1 SV=2
Length = 859
Score = 110 bits (274), Expect = 2e-023
Identities = 51/154 (33%), Positives = 88/154 (57%), Gaps = 1/154 (0%)
Frame = +2
Query: 374 VIQLALDLARGLSYLHSKVIVHRYVKSENMLLEPNKTLKIADFGVARVEAQNPQDMTGET 553
++ ++ +A G++YLH I+HR +KS NML+ + +KI+DFG ++ E +
Sbjct: 213 LVDWSMGIAGGMNYLHLHKIIHRDLKSPNMLITYDDVVKISDFGTSK-ELSDKSTKMSFA 271
Query: 554 GTLGYMAPEVLEGKAYNRKCDVYSFGVCLWEIYCCDMPYADCSFAEISHAVVHKNLRPEI 733
GT+ +MAPEV+ + + K D++SFGV LWE+ ++PY D + I V +L +
Sbjct: 272 GTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPV 331
Query: 734 PKCCPQSVANIMRRCWDPNPDKRPEMEEVVKLLE 835
P CP ++R+CW+ P RP +++ L+
Sbjct: 332 PSSCPDGFKILLRQCWNSKPRNRPSFRQILLHLD 365
>sp|Q60700|M3K12_MOUSE Mitogen-activated protein kinase kinase kinase 12 OS=Mus
musculus GN=Map3k12 PE=1 SV=1
Length = 888
Score = 110 bits (274), Expect = 2e-023
Identities = 51/154 (33%), Positives = 88/154 (57%), Gaps = 1/154 (0%)
Frame = +2
Query: 374 VIQLALDLARGLSYLHSKVIVHRYVKSENMLLEPNKTLKIADFGVARVEAQNPQDMTGET 553
++ ++ +A G++YLH I+HR +KS NML+ + +KI+DFG ++ E +
Sbjct: 246 LVDWSMGIAGGMNYLHLHKIIHRDLKSPNMLITYDDVVKISDFGTSK-ELSDKSTKMSFA 304
Query: 554 GTLGYMAPEVLEGKAYNRKCDVYSFGVCLWEIYCCDMPYADCSFAEISHAVVHKNLRPEI 733
GT+ +MAPEV+ + + K D++SFGV LWE+ ++PY D + I V +L +
Sbjct: 305 GTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPV 364
Query: 734 PKCCPQSVANIMRRCWDPNPDKRPEMEEVVKLLE 835
P CP ++R+CW+ P RP +++ L+
Sbjct: 365 PSSCPDGFKILLRQCWNSKPRNRPSFRQILLHLD 398
>sp|Q3U1V8|M3K9_MOUSE Mitogen-activated protein kinase kinase kinase 9 OS=Mus
musculus GN=Map3k9 PE=2 SV=1
Length = 1077
Score = 110 bits (274), Expect = 2e-023
Identities = 64/185 (34%), Positives = 99/185 (53%), Gaps = 15/185 (8%)
Frame = +2
Query: 374 VIQLALDLARGLSYLHSKVIV---HRYVKSENMLL--------EPNKTLKIADFGVARVE 520
++ A+ +ARG++YLH + IV HR +KS N+L+ NK L+I DFG+AR E
Sbjct: 235 LVNWAVQIARGMNYLHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILEITDFGLAR-E 293
Query: 521 AQNPQDMTGETGTLGYMAPEVLEGKAYNRKCDVYSFGVCLWEIYCCDMPYADCSFAEISH 700
M+ GT +MAPEV+ +++ DV+S+GV LWE+ ++P+ +++
Sbjct: 294 WHRTTKMSA-AGTYAWMAPEVIRASMFSKGSDVWSYGVLLWELLTGEVPFRGIDGLAVAY 352
Query: 701 AVVHKNLRPEIPKCCPQSVANIMRRCWDPNPDKRPEMEEVVKLLEAVNTSKGGGMIPPDK 880
V L IP CP+ A +M CW+P+P RP ++ L + S G +P D
Sbjct: 353 GVAMNKLALPIPSTCPEPFAKLMEDCWNPDPHSRPSFTSILDQLTTIEES-GFFEMPKDS 411
Query: 881 FQGCL 895
F CL
Sbjct: 412 FH-CL 415
>sp|Q63796|M3K12_RAT Mitogen-activated protein kinase kinase kinase 12 OS=Rattus
norvegicus GN=Map3k12 PE=1 SV=1
Length = 888
Score = 110 bits (273), Expect = 3e-023
Identities = 51/154 (33%), Positives = 88/154 (57%), Gaps = 1/154 (0%)
Frame = +2
Query: 374 VIQLALDLARGLSYLHSKVIVHRYVKSENMLLEPNKTLKIADFGVARVEAQNPQDMTGET 553
++ ++ +A G++YLH I+HR +KS NML+ + +KI+DFG ++ E +
Sbjct: 246 LVDWSMGIAGGMNYLHLHKIIHRDLKSPNMLITYDDVVKISDFGTSK-ELSDKSTKMSFA 304
Query: 554 GTLGYMAPEVLEGKAYNRKCDVYSFGVCLWEIYCCDMPYADCSFAEISHAVVHKNLRPEI 733
GT+ +MAPEV+ + + K D++SFGV LWE+ ++PY D + I V +L +
Sbjct: 305 GTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPV 364
Query: 734 PKCCPQSVANIMRRCWDPNPDKRPEMEEVVKLLE 835
P CP ++R+CW+ P RP +++ L+
Sbjct: 365 PSSCPDGFKILLRQCWNRKPRNRPSFRQILLHLD 398
>sp|Q8VDG6|M3KL4_MOUSE Mitogen-activated protein kinase kinase kinase OS=Mus
musculus GN=Mlk4 PE=2 SV=2
Length = 1002
Score = 110 bits (273), Expect = 3e-023
Identities = 60/171 (35%), Positives = 95/171 (55%), Gaps = 13/171 (7%)
Frame = +2
Query: 362 PIKDVIQLALDLARGLSYLHSKVIV---HRYVKSENMLLEP--------NKTLKIADFGV 508
P + ++ A+ +ARG+ YLH + +V HR +KS N+LL NKTLKI DFG+
Sbjct: 217 PPQVLVNWAVQIARGMLYLHEEAVVPILHRDLKSSNILLLEKIEHDDICNKTLKITDFGL 276
Query: 509 ARVEAQNPQDMTGETGTLGYMAPEVLEGKAYNRKCDVYSFGVCLWEIYCCDMPYADCSFA 688
AR E M+ GT +MAPEV+ +++ D++S+GV LWE+ ++PY
Sbjct: 277 AR-EWHRTTRMSA-AGTYAWMAPEVIRSSLFSKGSDIWSYGVLLWELLTGEVPYRGIDGL 334
Query: 689 EISHAVVHKNLRPEIPKCCPQSVANIMRRCWDPNPDKRPEMEEVVKLLEAV 841
+++ V L IP CP+ A +M+ CW+ +P RP +++ L A+
Sbjct: 335 AVAYGVAVNKLTLPIPSTCPEPFAKLMKECWEQDPHIRPSFALILQQLTAI 385
>sp|Q5TCX8|M3KL4_HUMAN Mitogen-activated protein kinase kinase kinase OS=Homo
sapiens GN=MLK4 PE=1 SV=1
Length = 1036
Score = 109 bits (271), Expect = 5e-023
Identities = 63/193 (32%), Positives = 101/193 (52%), Gaps = 13/193 (6%)
Frame = +2
Query: 296 SLSMLLVAPSRSSLSRSIAPNSPIKDVIQLALDLARGLSYLHSKV---IVHRYVKSENML 466
+L+ AP + A P ++ A+ +ARG+ YLH + I+HR +KS N+L
Sbjct: 211 ALAAANAAPDPRAPGPRRARRIPPHVLVNWAVQIARGMLYLHEEAFVPILHRDLKSSNIL 270
Query: 467 LEP--------NKTLKIADFGVARVEAQNPQDMTGETGTLGYMAPEVLEGKAYNRKCDVY 622
L NKTLKI DFG+AR + + T GT +MAPEV++ +++ D++
Sbjct: 271 LLEKIEHDDICNKTLKITDFGLAREWHRTTKMST--AGTYAWMAPEVIKSSLFSKGSDIW 328
Query: 623 SFGVCLWEIYCCDMPYADCSFAEISHAVVHKNLRPEIPKCCPQSVANIMRRCWDPNPDKR 802
S+GV LWE+ ++PY +++ V L IP CP+ A +M+ CW +P R
Sbjct: 329 SYGVLLWELLTGEVPYRGIDGLAVAYGVAVNKLTLPIPSTCPEPFAKLMKECWQQDPHIR 388
Query: 803 PEMEEVVKLLEAV 841
P +++ L A+
Sbjct: 389 PSFALILEQLTAI 401
>sp|Q23915|KINX_DICDI Probable serine/threonine-protein kinase kinX
OS=Dictyostelium discoideum GN=kinX PE=3 SV=2
Length = 1094
Score = 108 bits (268), Expect = 1e-022
Identities = 62/169 (36%), Positives = 100/169 (59%), Gaps = 9/169 (5%)
Frame = +2
Query: 383 LALDLARGLSYLHSKVIVHRYVKSENMLLEPNKTLKIADFGVAR-VEAQNPQDMTGETGT 559
+ALD++ +SYLHSK IVHR +KS N+L++ N +K+ DFG AR VE N + MT GT
Sbjct: 126 IALDVSLAMSYLHSKSIVHRDLKSTNLLVDKNWKIKVCDFGFARIVEEDNNKSMT-ICGT 184
Query: 560 LGYMAPEVLEGKAYNRKCDVYSFGVCLWEIYCCDMP---YADCSFAEISHAVVHKNLRPE 730
+M+PE++ G Y+ + D++SFG+ L EI P D SF ++ +V L
Sbjct: 185 DNWMSPEMITGLDYDERSDIFSFGIVLLEIISRVKPAPYMRDASFG-LAEDIVRNQL--- 240
Query: 731 IPKCCPQSVANIMRRCWDPNPDKRPEMEEVVKLLEAVNTSKGGGMIPPD 877
IP CP+S+ ++ C +P+ RP +E+ + L+ + T+ ++ P+
Sbjct: 241 IPTDCPESLIDLTFNCCSVDPNNRPSFKEISQTLKQIKTTLDSNIVYPE 289
>sp|A8X775|DLK1_CAEBR Mitogen-activated protein kinase kinase kinase dlk-1
OS=Caenorhabditis briggsae GN=dlk-1 PE=3 SV=1
Length = 857
Score = 100 bits (247), Expect = 3e-020
Identities = 47/143 (32%), Positives = 80/143 (55%)
Frame = +2
Query: 392 DLARGLSYLHSKVIVHRYVKSENMLLEPNKTLKIADFGVARVEAQNPQDMTGETGTLGYM 571
++A G+ YLH ++HR +KS N+L+ ++KI DFG + ++ +N M GT+ +M
Sbjct: 156 EIADGMHYLHQNKVIHRDLKSPNILISAEDSIKICDFGTSHLQKKNDSTMMSFCGTVSWM 215
Query: 572 APEVLEGKAYNRKCDVYSFGVCLWEIYCCDMPYADCSFAEISHAVVHKNLRPEIPKCCPQ 751
APE+++ + N K DVYSFGV LWE+ + PYA+ + I V L +P+ P+
Sbjct: 216 APEMIKKEPCNEKVDVYSFGVVLWEMLTRETPYANIAQMAIIFGVGTNILNLPMPEEAPR 275
Query: 752 SVANIMRRCWDPNPDKRPEMEEV 820
+ ++++C RP +
Sbjct: 276 GLVLLIKQCLSQKGRNRPSFSHI 298
Database: UniProt/SwissProt
Posted date: Sat Aug 07 14:36:18 2010
Number of letters in database: 182,829,261
Number of sequences in database: 518,415
Lambda K H
0.267 0.041 0.140
Gapped
Lambda K H
0.267 0.041 0.140
Matrix: blosum62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 187,161,879,332
Number of Sequences: 518415
Number of Extensions: 187161879332
Number of Successful Extensions: 1147171164
Number of sequences better than 0.0: 0
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