BLASTX 7.6.2
Query= UN50492 /QuerySize=1157
(1156 letters)
Database: UniProt/SwissProt;
518,415 sequences; 182,829,261 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q7G764|NADO1_ORYSJ Probable NAD(P)H-dependent oxidoreductase ... 201 1e-050
sp|Q7G765|NADO2_ORYSJ Probable NAD(P)H-dependent oxidoreductase ... 200 2e-050
sp|P26690|6DCS_SOYBN NAD(P)H-dependent 6'-deoxychalcone synthase... 195 5e-049
sp|Q3ZCJ2|AK1A1_BOVIN Alcohol dehydrogenase [NADP+] OS=Bos tauru... 174 1e-042
sp|P51635|AK1A1_RAT Alcohol dehydrogenase [NADP+] OS=Rattus norv... 174 1e-042
sp|Q9JII6|AK1A1_MOUSE Alcohol dehydrogenase [NADP+] OS=Mus muscu... 173 4e-042
sp|P50578|AK1A1_PIG Alcohol dehydrogenase [NADP+] OS=Sus scrofa ... 173 4e-042
sp|Q568L5|A1A1B_DANRE Alcohol dehydrogenase [NADP+] B OS=Danio r... 172 5e-042
sp|Q5R5D5|AK1A1_PONAB Alcohol dehydrogenase [NADP+] OS=Pongo abe... 172 6e-042
sp|P14550|AK1A1_HUMAN Alcohol dehydrogenase [NADP+] OS=Homo sapi... 171 1e-041
sp|Q55FL3|ALRC_DICDI Aldose reductase C OS=Dictyostelium discoid... 166 3e-040
sp|Q54NZ7|ALRB_DICDI Aldose reductase B OS=Dictyostelium discoid... 166 4e-040
sp|O42888|YBN4_SCHPO Uncharacterized oxidoreductase C8E4.04 OS=S... 165 8e-040
sp|P27800|ALDX_SPOSA Aldehyde reductase 1 OS=Sporobolomyces salm... 163 2e-039
sp|Q5ZK84|AK1A1_CHICK Alcohol dehydrogenase [NADP+] OS=Gallus ga... 161 8e-039
sp|P14065|GCY_YEAST Protein GCY OS=Saccharomyces cerevisiae GN=G... 160 2e-038
sp|O70473|AK1A1_CRIGR Alcohol dehydrogenase [NADP+] (Fragment) O... 160 2e-038
sp|Q6GMC7|AK1A1_XENLA Alcohol dehydrogenase [NADP+] OS=Xenopus l... 160 2e-038
sp|Q6IMN8|ALRA_DICDI Aldose reductase A OS=Dictyostelium discoid... 159 5e-038
sp|P28475|S6PD_MALDO NADP-dependent D-sorbitol-6-phosphate dehyd... 158 9e-038
>sp|Q7G764|NADO1_ORYSJ Probable NAD(P)H-dependent oxidoreductase 1 OS=Oryza
sativa subsp. japonica GN=Os10g0113000 PE=1 SV=1
Length = 321
Score = 201 bits (509), Expect = 1e-050
Identities = 107/234 (45%), Positives = 151/234 (64%), Gaps = 6/234 (2%)
Frame = +2
Query: 92 IPLLGMGTYC-PQKDRESTILAVHQAIKIGYRHFDTAKIYGSEEALGTALGQAISYGTV- 265
+P +GMGT P E T A+ +AI++GYRHFDTA+IY +E +G A+ +A+ G +
Sbjct: 16 MPRVGMGTAAFPFTSSEDTTAAMLRAIELGYRHFDTARIYATEGCVGEAVAEAVRRGLIA 75
Query: 266 PREDIFVTSKL*SSDHH--DPISALTQTLKTMGLEYLDNYLVHWPIKLKPGVSE-PIPKE 436
R D+FVTSK+ SD H + A +TL+ +G++Y+D LVHWP+ L PG + P PK
Sbjct: 76 SRADVFVTSKIWCSDLHAGRVVPAARETLRNLGMDYVDLLLVHWPVSLTPGNYDFPFPK- 134
Query: 437 EEFEKDVGIEETWQGMERCLEMGLCRSIGVSNFSSKKIYDLLDFASVYPSVNQVEMHPLW 616
E +E W+GME C +GL R+IGVSNFS+KK+ LL A+V P+VNQVE++P+W
Sbjct: 135 EVILPSFDMEGVWRGMEECHRLGLARAIGVSNFSAKKLEQLLSLAAVRPAVNQVEVNPMW 194
Query: 617 RQSKLRKVCNENKIHVSGYSPLGGPGNCWGSTAVIEHPVIKFIALKHSVTPAQV 778
+Q LR+VC + + GYSPLG G WGS AV++ V++ IA T AQ+
Sbjct: 195 QQRTLREVCRREGVQLCGYSPLGAKGTPWGSAAVMDSGVLQEIAGAKGKTLAQI 248
>sp|Q7G765|NADO2_ORYSJ Probable NAD(P)H-dependent oxidoreductase 2 OS=Oryza
sativa subsp. japonica GN=Os10g0113100 PE=2 SV=1
Length = 322
Score = 200 bits (508), Expect = 2e-050
Identities = 108/234 (46%), Positives = 148/234 (63%), Gaps = 6/234 (2%)
Frame = +2
Query: 92 IPLLGMGTYC-PQKDRESTILAVHQAIKIGYRHFDTAKIYGSEEALGTALGQAISYGTV- 265
+P +GMGT P E T A+ +AI++GYRHFDTA++Y +E + A+ +A+ G V
Sbjct: 18 MPRIGMGTAAFPFTSSEETTAALLRAIELGYRHFDTARLYATEGCVSEAVAEAVRRGLVA 77
Query: 266 PREDIFVTSKL*SSDHH--DPISALTQTLKTMGLEYLDNYLVHWPIKLKPGVSE-PIPKE 436
R D+FVTSKL SD H + A +TL+ +G++Y+D LVHWP + PG + P PK
Sbjct: 78 SRADVFVTSKLWCSDLHAGRVVPAARETLRNLGMDYVDLLLVHWPATVAPGSYDFPFPK- 136
Query: 437 EEFEKDVGIEETWQGMERCLEMGLCRSIGVSNFSSKKIYDLLDFASVYPSVNQVEMHPLW 616
EE +E W+GME C +GL R+IGVSNFS+KK+ LL FA V P+ NQVEM+P+W
Sbjct: 137 EEMAPAFDMEGVWRGMEECHRLGLARAIGVSNFSAKKLEQLLSFAVVRPAANQVEMNPMW 196
Query: 617 RQSKLRKVCNENKIHVSGYSPLGGPGNCWGSTAVIEHPVIKFIALKHSVTPAQV 778
+Q LR+VC + + GYSPLG G WGS AV++ V+ IA T AQ+
Sbjct: 197 QQRTLREVCRREGVQLCGYSPLGAKGTPWGSAAVMDSGVLHDIAQTKGKTLAQI 250
>sp|P26690|6DCS_SOYBN NAD(P)H-dependent 6'-deoxychalcone synthase OS=Glycine max
PE=1 SV=1
Length = 315
Score = 195 bits (495), Expect = 5e-049
Identities = 111/233 (47%), Positives = 155/233 (66%), Gaps = 6/233 (2%)
Frame = +2
Query: 92 IPLLGMGTYCPQKDRESTILAVHQAIKIGYRHFDTAKIYGSEEALGTALGQAISYGTVPR 271
+P++GMG+ ++ T A+ +A+K GYRHFDTA YGSE+ALG AL +AI G V R
Sbjct: 21 MPVVGMGSAPDFTCKKDTKEAIIEAVKQGYRHFDTAAAYGSEQALGEALKEAIHLGLVSR 80
Query: 272 EDIFVTSKL*SSDHHD--PISALTQTLKTMGLEYLDNYLVHWPIKLKPG-VSEPIPKEEE 442
+D+FVTSKL +++H + AL ++LKT+ LEYLD YL+HWP+ +PG S PI E+
Sbjct: 81 QDLFVTSKLWVTENHPHLVLPALRKSLKTLQLEYLDLYLIHWPLSSQPGKFSFPIEVEDL 140
Query: 443 FEKDVGIEETWQGMERCLEMGLCRSIGVSNFSSKKIYDLLDFASVYPSVNQVEMHPLWRQ 622
DV + W+ ME C ++GL ++IGVSNFS KK+ +LL A++ P V+QVEM+ W+Q
Sbjct: 141 LPFDV--KGVWESMEECQKLGLTKAIGVSNFSVKKLQNLLSVATIRPVVDQVEMNLAWQQ 198
Query: 623 SKLRKVCNENKIHVSGYSPLGGPGNCWGSTAVIEHPVIKFIALKHSVTPAQVS 781
KLR+ C EN I V+ +SPL G G V+E+ V+K IA H + AQVS
Sbjct: 199 KKLREFCKENGIIVTAFSPL-RKGASRGPNEVMENDVLKEIAEAHGKSIAQVS 250
>sp|Q3ZCJ2|AK1A1_BOVIN Alcohol dehydrogenase [NADP+] OS=Bos taurus GN=AKR1A1
PE=2 SV=1
Length = 325
Score = 174 bits (440), Expect = 1e-042
Identities = 100/251 (39%), Positives = 146/251 (58%), Gaps = 12/251 (4%)
Frame = +2
Query: 53 MRSDVARLRCGKMIPLLGMGTYCPQKDRESTILAVHQAIKIGYRHFDTAKIYGSEEALGT 232
M + L G+ +PL+G+GT+ + D A+ A+ +GYRH D A IYG+E +G
Sbjct: 1 MAASCILLHTGQKMPLIGLGTW--KSDPGQVKAAIKYALSVGYRHIDCAAIYGNETEIGE 58
Query: 233 ALGQAISYG-TVPREDIFVTSKL*SSDHH--DPISALTQTLKTMGLEYLDNYLVHWPIKL 403
AL + + G VPRE++FVTSKL ++ HH D AL +TL + LEYLD YL+HWP
Sbjct: 59 ALKENVGPGKLVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAF 118
Query: 404 KPGVSEPIPKEEEFE---KDVGIEETWQGMERCLEMGLCRSIGVSNFSSKKIYDLLDFAS 574
+ G S P PK + +ETW+ +E + GL R++G+SNF+S++I D+L AS
Sbjct: 119 ERGDS-PFPKNADGTIRYDSTHYKETWRALEALVAKGLVRALGLSNFNSRQIDDVLSVAS 177
Query: 575 VYPSVNQVEMHPLWRQSKLRKVCNENKIHVSGYSPLGGPGNCW---GSTAVIEHPVIKFI 745
V P+V QVE HP Q++L C + V+ YSPLG W +++ PV+ +
Sbjct: 178 VRPAVLQVECHPYLAQNELIAHCQARNLEVTAYSPLGSSDRAWRDPEEPVLLKEPVVLAL 237
Query: 746 ALKHSVTPAQV 778
A KH +PAQ+
Sbjct: 238 AEKHGRSPAQI 248
>sp|P51635|AK1A1_RAT Alcohol dehydrogenase [NADP+] OS=Rattus norvegicus
GN=Akr1a1 PE=1 SV=2
Length = 325
Score = 174 bits (440), Expect = 1e-042
Identities = 97/251 (38%), Positives = 146/251 (58%), Gaps = 12/251 (4%)
Frame = +2
Query: 53 MRSDVARLRCGKMIPLLGMGTYCPQKDRESTILAVHQAIKIGYRHFDTAKIYGSEEALGT 232
M + L G+ +PL+G+GT+ + + A+ A+ +GYRH D A +YG+E +G
Sbjct: 1 MTASSVLLHTGQKMPLIGLGTW--KSEPGQVKAAIKYALSVGYRHIDCASVYGNETEIGE 58
Query: 233 ALGQAISYG-TVPREDIFVTSKL*SSDHH--DPISALTQTLKTMGLEYLDNYLVHWPIKL 403
AL +++ G VPRE++FVTSKL ++ HH D A+ +TL + LEYLD YL+HWP
Sbjct: 59 ALKESVGAGKAVPREELFVTSKLWNTKHHPEDVEPAVRKTLADLQLEYLDLYLMHWPYAF 118
Query: 404 KPGVSEPIPKEEEFE---KDVGIEETWQGMERCLEMGLCRSIGVSNFSSKKIYDLLDFAS 574
+ G P PK + +ETW+ +E + GL +++G+SNFSS++I D+L AS
Sbjct: 119 ERG-DNPFPKNADGTVKYDSTHYKETWKALEALVAKGLVKALGLSNFSSRQIDDVLSVAS 177
Query: 575 VYPSVNQVEMHPLWRQSKLRKVCNENKIHVSGYSPLGGPGNCW---GSTAVIEHPVIKFI 745
V P+V QVE HP Q++L C + V+ YSPLG W ++E PV+ +
Sbjct: 178 VRPAVLQVECHPYLAQNELIAHCQARGLEVTAYSPLGSSDRAWRHPDEPVLLEEPVVLAL 237
Query: 746 ALKHSVTPAQV 778
A KH +PAQ+
Sbjct: 238 AEKHGRSPAQI 248
>sp|Q9JII6|AK1A1_MOUSE Alcohol dehydrogenase [NADP+] OS=Mus musculus GN=Akr1a1
PE=1 SV=3
Length = 325
Score = 173 bits (436), Expect = 4e-042
Identities = 97/251 (38%), Positives = 146/251 (58%), Gaps = 12/251 (4%)
Frame = +2
Query: 53 MRSDVARLRCGKMIPLLGMGTYCPQKDRESTILAVHQAIKIGYRHFDTAKIYGSEEALGT 232
M + L G+ +PL+G+GT+ + + A+ A+ GYRH D A +YG+E +G
Sbjct: 1 MTASSVLLHTGQKMPLIGLGTW--KSEPGQVKAAIKHALSAGYRHIDCASVYGNETEIGE 58
Query: 233 ALGQAISYG-TVPREDIFVTSKL*SSDHH--DPISALTQTLKTMGLEYLDNYLVHWPIKL 403
AL +++ G VPRE++FVTSKL ++ HH D AL +TL + LEYLD YL+HWP
Sbjct: 59 ALKESVGSGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAF 118
Query: 404 KPGVSEPIPKEEEFE---KDVGIEETWQGMERCLEMGLCRSIGVSNFSSKKIYDLLDFAS 574
+ G P PK + +ETW+ +E + GL +++G+SNF+S++I D+L AS
Sbjct: 119 ERG-DNPFPKNADGTVRYDSTHYKETWKALEVLVAKGLVKALGLSNFNSRQIDDVLSVAS 177
Query: 575 VYPSVNQVEMHPLWRQSKLRKVCNENKIHVSGYSPLGGPGNCW---GSTAVIEHPVIKFI 745
V P+V QVE HP Q++L C+ + V+ YSPLG W ++E PV+ +
Sbjct: 178 VRPAVLQVECHPYLAQNELIAHCHARGLEVTAYSPLGSSDRAWRHPDEPVLLEEPVVLAL 237
Query: 746 ALKHSVTPAQV 778
A KH +PAQ+
Sbjct: 238 AEKHGRSPAQI 248
>sp|P50578|AK1A1_PIG Alcohol dehydrogenase [NADP+] OS=Sus scrofa GN=AKR1A1 PE=1
SV=2
Length = 325
Score = 173 bits (436), Expect = 4e-042
Identities = 98/251 (39%), Positives = 147/251 (58%), Gaps = 12/251 (4%)
Frame = +2
Query: 53 MRSDVARLRCGKMIPLLGMGTYCPQKDRESTILAVHQAIKIGYRHFDTAKIYGSEEALGT 232
M + L G+ +PL+G+GT+ + + A+ A+ +GYRH D A IYG+E +G
Sbjct: 1 MAASCVLLHTGQKMPLIGLGTW--KSEPGQVKAAIKYALTVGYRHIDCAAIYGNELEIGE 58
Query: 233 ALGQAISYG-TVPREDIFVTSKL*SSDHH--DPISALTQTLKTMGLEYLDNYLVHWPIKL 403
AL + + G VPRE++FVTSKL ++ HH D AL +TL + LEYLD YL+HWP
Sbjct: 59 ALTETVGPGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAF 118
Query: 404 KPGVSEPIPKEEEFE---KDVGIEETWQGMERCLEMGLCRSIGVSNFSSKKIYDLLDFAS 574
+ G P PK + ++TW+ +E + GL R++G+SNFSS++I D+L AS
Sbjct: 119 ERG-DNPFPKNADGTIRYDATHYKDTWKALEALVAKGLVRALGLSNFSSRQIDDVLSVAS 177
Query: 575 VYPSVNQVEMHPLWRQSKLRKVCNENKIHVSGYSPLGGPGNCW---GSTAVIEHPVIKFI 745
V P+V QVE HP Q++L C + V+ YSPLG W ++E PV++ +
Sbjct: 178 VRPAVLQVECHPYLAQNELIAHCQARGLEVTAYSPLGSSDRAWRDPNEPVLLEEPVVQAL 237
Query: 746 ALKHSVTPAQV 778
A K++ +PAQ+
Sbjct: 238 AEKYNRSPAQI 248
>sp|Q568L5|A1A1B_DANRE Alcohol dehydrogenase [NADP+] B OS=Danio rerio GN=akr1a1b
PE=2 SV=1
Length = 324
Score = 172 bits (435), Expect = 5e-042
Identities = 99/249 (39%), Positives = 147/249 (59%), Gaps = 12/249 (4%)
Frame = +2
Query: 59 SDVARLRCGKMIPLLGMGTYCPQKDRESTILAVHQAIKIGYRHFDTAKIYGSEEALGTAL 238
+D A L G+ +PLLG+GT+ + + AV A++ GYRH D A IY +E +G A
Sbjct: 2 NDFAVLSTGRKMPLLGLGTW--KSEPGLVKQAVIWALESGYRHIDCAPIYANEPEIGEAF 59
Query: 239 GQAISYGT-VPREDIFVTSKL*SSDHH--DPISALTQTLKTMGLEYLDNYLVHWPIKLKP 409
+ + + RED+FVTSKL ++ HH D +L +TLK + LEYLD YL+HWP +
Sbjct: 60 QETMGPDKGIRREDVFVTSKLWNTKHHPDDVEPSLLKTLKDLKLEYLDLYLIHWPYAFQR 119
Query: 410 GVSEPIPKEEE---FEKDVGIEETWQGMERCLEMGLCRSIGVSNFSSKKIYDLLDFASVY 580
G P P++E+ D+ + TW ME+ + GL R+IG+SNF+S++I D+L AS+
Sbjct: 120 G-DTPFPRKEDGTLLYDDIDYKLTWAAMEKLVGKGLVRAIGLSNFNSRQIDDILSVASIK 178
Query: 581 PSVNQVEMHPLWRQSKLRKVCNENKIHVSGYSPLGGPGNCW---GSTAVIEHPVIKFIAL 751
P+V QVE HP Q +L C + + ++ YSPLG P W ++E P I +A
Sbjct: 179 PTVLQVESHPYLAQVELLSHCRDRGLVMTAYSPLGSPDRAWKHPDEPVLLEEPAIAALAK 238
Query: 752 KHSVTPAQV 778
K++ TPAQ+
Sbjct: 239 KYNKTPAQI 247
>sp|Q5R5D5|AK1A1_PONAB Alcohol dehydrogenase [NADP+] OS=Pongo abelii GN=AKR1A1
PE=2 SV=1
Length = 325
Score = 172 bits (434), Expect = 6e-042
Identities = 99/251 (39%), Positives = 145/251 (57%), Gaps = 12/251 (4%)
Frame = +2
Query: 53 MRSDVARLRCGKMIPLLGMGTYCPQKDRESTILAVHQAIKIGYRHFDTAKIYGSEEALGT 232
M + L G+ +PL+G+GT+ + + AV A+ +GYRH D A IYG+E +G
Sbjct: 1 MAASCVLLHTGQKMPLIGLGTW--KSEPGQVKAAVKYALSVGYRHIDCAAIYGNEPEIGE 58
Query: 233 ALGQAISYG-TVPREDIFVTSKL*SSDHH--DPISALTQTLKTMGLEYLDNYLVHWPIKL 403
AL + + G VPRE++FVTSKL ++ HH D AL +TL + LEYLD YL+HWP
Sbjct: 59 ALKEDVGPGKAVPREELFVTSKLWNTKHHPEDVEPALQKTLADLQLEYLDLYLMHWPYAF 118
Query: 404 KPGVSEPIPKEEE---FEKDVGIEETWQGMERCLEMGLCRSIGVSNFSSKKIYDLLDFAS 574
+ G P PK + +ETW+ +E + GL R++G+SNF+S++I D+L AS
Sbjct: 119 ERG-DNPFPKNADGTICYDSTHYKETWKALEALVAKGLVRALGLSNFNSRQIDDILSVAS 177
Query: 575 VYPSVNQVEMHPLWRQSKLRKVCNENKIHVSGYSPLGGPGNCW---GSTAVIEHPVIKFI 745
V P+V QVE HP Q++L C + V+ YSPLG W ++E PV+ +
Sbjct: 178 VRPAVLQVECHPYLAQNELIAHCQARGLAVTAYSPLGSSDRAWRDPDEPVLLEEPVVLAL 237
Query: 746 ALKHSVTPAQV 778
A K+ +PAQ+
Sbjct: 238 AEKYGGSPAQI 248
>sp|P14550|AK1A1_HUMAN Alcohol dehydrogenase [NADP+] OS=Homo sapiens GN=AKR1A1
PE=1 SV=3
Length = 325
Score = 171 bits (432), Expect = 1e-041
Identities = 98/251 (39%), Positives = 145/251 (57%), Gaps = 12/251 (4%)
Frame = +2
Query: 53 MRSDVARLRCGKMIPLLGMGTYCPQKDRESTILAVHQAIKIGYRHFDTAKIYGSEEALGT 232
M + L G+ +PL+G+GT+ + + AV A+ +GYRH D A IYG+E +G
Sbjct: 1 MAASCVLLHTGQKMPLIGLGTW--KSEPGQVKAAVKYALSVGYRHIDCAAIYGNEPEIGE 58
Query: 233 ALGQAISYG-TVPREDIFVTSKL*SSDHH--DPISALTQTLKTMGLEYLDNYLVHWPIKL 403
AL + + G VPRE++FVTSKL ++ HH D AL +TL + LEYLD YL+HWP
Sbjct: 59 ALKEDVGPGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAF 118
Query: 404 KPGVSEPIPKEEE---FEKDVGIEETWQGMERCLEMGLCRSIGVSNFSSKKIYDLLDFAS 574
+ G P PK + +ETW+ +E + GL +++G+SNF+S++I D+L AS
Sbjct: 119 ERG-DNPFPKNADGTICYDSTHYKETWKALEALVAKGLVQALGLSNFNSRQIDDILSVAS 177
Query: 575 VYPSVNQVEMHPLWRQSKLRKVCNENKIHVSGYSPLGGPGNCW---GSTAVIEHPVIKFI 745
V P+V QVE HP Q++L C + V+ YSPLG W ++E PV+ +
Sbjct: 178 VRPAVLQVECHPYLAQNELIAHCQARGLEVTAYSPLGSSDRAWRDPDEPVLLEEPVVLAL 237
Query: 746 ALKHSVTPAQV 778
A K+ +PAQ+
Sbjct: 238 AEKYGRSPAQI 248
>sp|Q55FL3|ALRC_DICDI Aldose reductase C OS=Dictyostelium discoideum GN=alrC
PE=3 SV=1
Length = 321
Score = 166 bits (419), Expect = 3e-040
Identities = 97/247 (39%), Positives = 143/247 (57%), Gaps = 19/247 (7%)
Frame = +2
Query: 71 RLRCGKMIPLLGMGTYCPQKDRESTILAVHQAIKIGYRHFDTAKIYGSEEALGTALGQAI 250
+L G IP +G+GTY + E A++ A+K GYRH D A YG+E+ +G +L +
Sbjct: 18 KLNDGNQIPSIGLGTYYSENPGEVGD-AINNALKNGYRHIDGAAFYGNEKVIGNSLKEIF 76
Query: 251 SYGTVPREDIFVTSKL*SSDHHD--PISALTQTLKTMGLEYLDNYLVHWPIKLKPGVSEP 424
G + REDIF TSKL +S H+ + +T++ +G+ YLD YL+HWPI + S P
Sbjct: 77 KEGEIKREDIFYTSKLWNSCHNSNLVVKHCVKTIEDLGIGYLDLYLIHWPIAFEN--SNP 134
Query: 425 IPKEEEFEKD---------VGIEETWQGMERCLEMGLCRSIGVSNFSSKKIYDLLDFASV 577
+ E +D V I ETWQ ME+ +E+GL +SIGVSNF+ + + DLL +A +
Sbjct: 135 LGLTIEPLRDQNGNPIIAPVSIRETWQEMEKLVELGLVKSIGVSNFNVQNLVDLLTYAKI 194
Query: 578 YPSVNQVEMHPLWRQSKLRKVCNENKIHVSGYSPLGGPGNCWGSTAVIEHPVIKFIALKH 757
P VNQVE+HP Q KL++ C++ +I + YSPLG G + ++K IA K+
Sbjct: 195 KPVVNQVEIHPYLTQFKLQEYCDKYEIKLVAYSPLG-----QGKCDFFSNKILKSIAGKY 249
Query: 758 SVTPAQV 778
+ A V
Sbjct: 250 KKSVANV 256
>sp|Q54NZ7|ALRB_DICDI Aldose reductase B OS=Dictyostelium discoideum GN=alrB
PE=3 SV=2
Length = 311
Score = 166 bits (418), Expect = 4e-040
Identities = 99/238 (41%), Positives = 139/238 (58%), Gaps = 15/238 (6%)
Frame = +2
Query: 92 IPLLGMGTYCPQKDRESTILAVHQAIKIGYRHFDTAKIYGSEEALGTALGQAISYGTVPR 271
IP++G+GTY K E AV A+K GYRH D A IY +E+ +G AL + + G + R
Sbjct: 17 IPMIGLGTYNGAKVGEVGD-AVKVALKSGYRHIDGAAIYMNEKEIGHALKEVFAEGEIKR 75
Query: 272 EDIFVTSKL*SSDHHDPI--SALTQTLKTMGLEYLDNYLVHWPIKLKPG-----VSEPIP 430
EDIF SKL +S HH + +TL+ +GLEYLD YL+HWPI + ++P+
Sbjct: 76 EDIFYVSKLWNSCHHASLVRKHCEKTLEDLGLEYLDLYLIHWPIAFENADPSGTTTQPLR 135
Query: 431 KE--EEFEKDVGIEETWQGMERCLEMGLCRSIGVSNFSSKKIYDLLDFASVYPSVNQVEM 604
E V I ETWQ ME+ +E GL +SIGVSNF+ + + DLL +A + P++NQVE+
Sbjct: 136 DSDGEPVLAAVSIRETWQEMEKLVEYGLVKSIGVSNFNVQNLVDLLTYAKIKPAINQVEV 195
Query: 605 HPLWRQSKLRKVCNENKIHVSGYSPLGGPGNCWGSTAVIEHPVIKFIALKHSVTPAQV 778
HP Q L+ C+ I ++ YSPLG G ++ + +K IA KH+ T A V
Sbjct: 196 HPYLSQPNLKYFCDRYGIVLTAYSPLG-----QGKCDLLSNETLKSIADKHNKTVANV 248
>sp|O42888|YBN4_SCHPO Uncharacterized oxidoreductase C8E4.04
OS=Schizosaccharomyces pombe GN=SPBC8E4.04 PE=2 SV=1
Length = 325
Score = 165 bits (416), Expect = 8e-040
Identities = 104/258 (40%), Positives = 150/258 (58%), Gaps = 16/258 (6%)
Frame = +2
Query: 35 KKREREMRSDVARLRCGKMIPLLGMGTYCPQKDRESTILAVHQAIKIGYRHFDTAKIYGS 214
K+ + R L G IP +G+GT+ KD T AV A+K GYRH DTA IYG+
Sbjct: 4 KEFAKNAREAYFTLPNGDKIPSIGLGTWRSGKD--ETKNAVCAALKAGYRHIDTAHIYGN 61
Query: 215 EEALGTALGQAISYGTVPREDIFVTSKL*SSDHHDPI--SALTQTLKTMGLEYLDNYLVH 388
E+ +G+ I VPR DI+VTSKL + H + AL +TL+ + LEY+D YL+H
Sbjct: 62 EK----EIGEGIRESGVPRTDIWVTSKLWCNAHRAGLVPLALEKTLQDLNLEYIDAYLIH 117
Query: 389 WPIKLKPGVSEPIPKEEEFE---KDVGIEETWQGMERCLEMGLCRSIGVSNFSSKKIYDL 559
WP L G E +P+ E+ E +DV IEETWQ ME LE G R IG+SNF+++ + +
Sbjct: 118 WPFALLSG-PEELPRNEKGELIYEDVPIEETWQAMEELLETGKVRYIGISNFNNEYLDRV 176
Query: 560 LDFASVYPSVNQVEMHPLWRQSKLRKVCNENKIHVSGYSPLGGPGNCWGS--TAVIEHPV 733
L A V P+++Q+E+HP Q++ + + +IHVS YSPL + + S + +IEH
Sbjct: 177 LKIAKVKPTIHQMELHPYLPQTEYLEKHKKLQIHVSAYSPLANQNDAYNSDISKLIEHKT 236
Query: 734 IKFI--ALKHSVTPAQVS 781
+ I A +TPA ++
Sbjct: 237 LVDIANARGEGITPANIA 254
>sp|P27800|ALDX_SPOSA Aldehyde reductase 1 OS=Sporobolomyces salmonicolor GN=ARI
PE=1 SV=3
Length = 323
Score = 163 bits (412), Expect = 2e-039
Identities = 96/251 (38%), Positives = 144/251 (57%), Gaps = 17/251 (6%)
Frame = +2
Query: 74 LRCGKMIPLLGMGTYCPQKDRESTILAVHQAIKIGYRHFDTAKIYGSEEALGTALGQAIS 253
L G + L+G GT+ Q V AI+ GYRH D AK+Y ++ +G A+ +A
Sbjct: 7 LNTGASLELVGYGTW--QAAPGEVGQGVKVAIETGYRHLDLAKVYSNQPEVGAAIKEA-- 62
Query: 254 YGTVPREDIFVTSKL*SSDH--HDPISALTQTLKTMGLEYLDNYLVHWPIKLKP--GVSE 421
V RED+F+TSKL ++ H AL TLK +GLEYLD YL+HWP+ P +++
Sbjct: 63 --GVKREDLFITSKLWNNSHRPEQVEPALDDTLKELGLEYLDLYLIHWPVAFPPEGDITQ 120
Query: 422 PI-----PKEEEFEKDVGIEETWQGMERCLEMGLCRSIGVSNFSSKKIYDLLDFASVYPS 586
+ KE + + +V + +TW+ M + L+ G ++IGVSNF +K + +++ V PS
Sbjct: 121 NLFPKANDKEVKLDLEVSLVDTWKAMVKLLDTGKVKAIGVSNFDAKMVDAIIEATGVTPS 180
Query: 587 VNQVEMHPLWRQSKLRKVCNENKIHVSGYSPLGGPGNCWGSTAVIEHPVIKFIALKHSVT 766
VNQ+E HPL Q +L IH++ YSPLG N G+ +++HP IK IA K+ T
Sbjct: 181 VNQIERHPLLLQPELIAHHKAKNIHITAYSPLG--NNTVGAPLLVQHPEIKRIAEKNGCT 238
Query: 767 PAQVSSLFVLI 799
PAQV + ++
Sbjct: 239 PAQVLIAWAIV 249
>sp|Q5ZK84|AK1A1_CHICK Alcohol dehydrogenase [NADP+] OS=Gallus gallus GN=AKR1A1
PE=2 SV=1
Length = 327
Score = 161 bits (407), Expect = 8e-039
Identities = 95/248 (38%), Positives = 142/248 (57%), Gaps = 12/248 (4%)
Frame = +2
Query: 62 DVARLRCGKMIPLLGMGTYCPQKDRESTILAVHQAIKIGYRHFDTAKIYGSEEALGTALG 241
D L G+ IPL+G+GT+ + + AV A+ +GYRH D A Y +E +G A
Sbjct: 6 DFVALYNGQKIPLIGLGTWKSEPGQVKE--AVKYALSVGYRHVDCAAAYSNEAEIGDAFQ 63
Query: 242 QAISYG-TVPREDIFVTSKL*SSDHH--DPISALTQTLKTMGLEYLDNYLVHWPIKLKPG 412
+ + + RED+FVTSKL ++ HH D AL +TL + L+YLD YL+HWP + G
Sbjct: 64 ECVGPNKVIKREDLFVTSKLWNTKHHPEDVEPALRKTLADLKLDYLDLYLMHWPHAFERG 123
Query: 413 VSEPIPKEEEFEKD---VGIEETWQGMERCLEMGLCRSIGVSNFSSKKIYDLLDFASVYP 583
PK + ++TW+ ME+ +E GL ++IG+SNF+S++I D+L A+V P
Sbjct: 124 -DNLFPKNPDGTMRYDYTDYKDTWKAMEKLVEKGLAKAIGLSNFNSRQIDDVLSVATVKP 182
Query: 584 SVNQVEMHPLWRQSKLRKVCNENKIHVSGYSPLGGPGNCW---GSTAVIEHPVIKFIALK 754
+V QVE HP Q++L C + + V+ YSPLG P W ++E P IK +A K
Sbjct: 183 AVLQVECHPYLAQNELIAHCQKRGLVVTAYSPLGSPDRMWKHPDEPVLLEEPGIKKLAEK 242
Query: 755 HSVTPAQV 778
+ +PAQ+
Sbjct: 243 YKKSPAQI 250
>sp|P14065|GCY_YEAST Protein GCY OS=Saccharomyces cerevisiae GN=GCY1 PE=1 SV=1
Length = 312
Score = 160 bits (404), Expect = 2e-038
Identities = 99/250 (39%), Positives = 137/250 (54%), Gaps = 23/250 (9%)
Frame = +2
Query: 65 VARLRCGKMIPLLGMGTYCPQKDRESTILAVHQAIKIGYRHFDTAKIYGSEEALGTALGQ 244
+ L G IP +G+GT+ Q AV A+K GYRH DTA IY +E+ +GQ
Sbjct: 11 ILSLNTGAQIPQIGLGTW--QSKENDAYKAVLTALKDGYRHIDTAAIYRNED----QVGQ 64
Query: 245 AISYGTVPREDIFVTSKL*SSDHHDPISALTQTLKTMGLEYLDNYLVHWPIKLKPG---- 412
AI VPRE+IFVT+KL + HH+P AL Q+LK +GL+Y+D YL+HWP +L P
Sbjct: 65 AIKDSGVPREEIFVTTKLWCTQHHEPEVALDQSLKRLGLDYVDLYLMHWPARLDPAYIKN 124
Query: 413 ---VSEPIPKEEEFEKDV---GIEETWQGMERCLEMGLCRSIGVSNFSSKKIYDLL--DF 568
+S P K+ D+ +TW+ M+ + G +++GVSNFS + DLL
Sbjct: 125 EDILSVPTKKDGSRAVDITNWNFIKTWELMQELPKTGKTKAVGVSNFSINNLKDLLASQG 184
Query: 569 ASVYPSVNQVEMHPLWRQSKLRKVCNENKIHVSGYSPLGGPGNCWGSTAVIEHPVIKFIA 748
+ P+ NQVE+HPL Q +L C I V YSPLG +++ PVI IA
Sbjct: 185 NKLTPAANQVEIHPLLPQDELINFCKSKGIVVEAYSPLGST-----DAPLLKEPVILEIA 239
Query: 749 LKHSVTPAQV 778
K++V P V
Sbjct: 240 KKNNVQPGHV 249
>sp|O70473|AK1A1_CRIGR Alcohol dehydrogenase [NADP+] (Fragment) OS=Cricetulus
griseus GN=AKR1A1 PE=2 SV=1
Length = 228
Score = 160 bits (403), Expect = 2e-038
Identities = 90/229 (39%), Positives = 135/229 (58%), Gaps = 12/229 (5%)
Frame = +2
Query: 98 LLGMGTYCPQKDRESTILAVHQAIKIGYRHFDTAKIYGSEEALGTALGQAISYG-TVPRE 274
L+G+GT+ + + A+ A+ +GYRH D A +YG+E +G AL + + G VPRE
Sbjct: 1 LIGLGTW--KSNPGQVKAAIKYALSVGYRHIDCAAVYGNEIEIGEALKENVGPGKAVPRE 58
Query: 275 DIFVTSKL*SSDHH--DPISALTQTLKTMGLEYLDNYLVHWPIKLKPGVSEPIPKEEEFE 448
++FVTSKL ++ HH D +AL +TL + LEYLD YL+HWP + G P PK ++
Sbjct: 59 ELFVTSKLWNTKHHPEDVEAALRKTLADLQLEYLDLYLMHWPYAFERG-DNPFPKNDDGT 117
Query: 449 ---KDVGIEETWQGMERCLEMGLCRSIGVSNFSSKKIYDLLDFASVYPSVNQVEMHPLWR 619
+ETW+ +E + GL +++G+SNF+S++I D+L ASV P+V QVE HP
Sbjct: 118 IRYDSTHYKETWKALEALVAKGLVKALGLSNFNSRQIDDILSVASVRPAVLQVECHPYLA 177
Query: 620 QSKLRKVCNENKIHVSGYSPLGGPGNCW---GSTAVIEHPVIKFIALKH 757
Q++L C + V+ YSPLG W ++E PV+ +A KH
Sbjct: 178 QNELIAHCQARGLEVTAYSPLGSSDRAWRHPDEPVLLEEPVVLALAEKH 226
>sp|Q6GMC7|AK1A1_XENLA Alcohol dehydrogenase [NADP+] OS=Xenopus laevis GN=akr1a1
PE=2 SV=1
Length = 327
Score = 160 bits (403), Expect = 2e-038
Identities = 90/246 (36%), Positives = 150/246 (60%), Gaps = 16/246 (6%)
Frame = +2
Query: 74 LRCGKMIPLLGMGTY--CPQKDRESTILAVHQAIKIGYRHFDTAKIYGSEEALGTALGQA 247
L G+ +PL+G+GT+ P + ++ AV A+ +GYRH D A +YG+E +G A+ ++
Sbjct: 10 LYTGQKMPLIGLGTWKSAPGQVKD----AVKYALGVGYRHIDCAFVYGNETEVGEAIKES 65
Query: 248 ISYGT-VPREDIFVTSKL*SSDHH--DPISALTQTLKTMGLEYLDNYLVHWPIKLKPGVS 418
+ + RE++FVTSKL ++ HH D AL +TL+ + L+YLD YL+HWP K G
Sbjct: 66 VGPDKGLKREEVFVTSKLWNNKHHPDDVECALRKTLQELQLDYLDLYLMHWPYAFKRG-D 124
Query: 419 EPIPKEEEFEKDVGI---EETWQGMERCLEMGLCRSIGVSNFSSKKIYDLLDFASVYPSV 589
+ P+ + + ++TW+ ME+ +E GL ++IG+SNF+ +++ D+L A+V P+V
Sbjct: 125 QVFPQNPDGSVQYDLTDYKDTWKAMEKLVEKGLAKAIGLSNFNKRQMDDILSIATVKPAV 184
Query: 590 NQVEMHPLWRQSKLRKVCNENKIHVSGYSPLGGPGNCW---GSTAVIEHPVIKFIALKHS 760
QVE HP Q++L C + + ++GYSPLG P W ++E P I +A K++
Sbjct: 185 LQVECHPYLAQNELIACCRSHGLVLTGYSPLGSPDRSWRKPEDPVLLEEPGIIAMAKKYN 244
Query: 761 VTPAQV 778
++ AQ+
Sbjct: 245 ISEAQI 250
>sp|Q6IMN8|ALRA_DICDI Aldose reductase A OS=Dictyostelium discoideum GN=alrA
PE=2 SV=1
Length = 297
Score = 159 bits (400), Expect = 5e-038
Identities = 91/237 (38%), Positives = 144/237 (60%), Gaps = 17/237 (7%)
Frame = +2
Query: 71 RLRCGKMIPLLGMGTYCPQKDRESTIL--AVHQAIKIGYRHFDTAKIYGSEEALGTALGQ 244
+L G IPL+G GT+ E+T++ AV A+ GYRH D A +Y +E+ +G A +
Sbjct: 6 KLSSGHKIPLVGFGTW----KAETTLVGKAVEVALDAGYRHIDCAAVYLNEKEVGEAFTK 61
Query: 245 AI-SYGTVPREDIFVTSKL*SSDH--HDPISALTQTLKTMGLEYLDNYLVHWPIKLKPGV 415
+ TV RED+F+TSKL ++ H AL +TL +GL+YLD YLVHWP+ +
Sbjct: 62 KFTTEATVKREDVFITSKLWNTFHKKEHVRPALERTLSDLGLQYLDLYLVHWPVAFE-YT 120
Query: 416 SEPIPKEEEFEKDVGIEETWQGMERCLEMGLCRSIGVSNFSSKKIYDLLDFASVYPSVNQ 595
S I ++ V I ETW+ ME+ ++ GL +SIG+SNF+ + + ++L +A + P+ NQ
Sbjct: 121 SNDIQTSGSTQEFVSIRETWEEMEKLVDAGLVKSIGLSNFNVQGLMEVLSYARIKPAANQ 180
Query: 596 VEMHPLWRQSKLRKVCNENKIHVSGYSPLGGPGNCWGSTAVIEHPVIKFIALKHSVT 766
VE+HP Q +L+K C+++ IH++ YSPL G+ A +++ + IA K++ T
Sbjct: 181 VELHPFLSQPELKKFCDKHNIHLTAYSPL-------GNGAFVDNEEVGAIAKKYNKT 230
>sp|P28475|S6PD_MALDO NADP-dependent D-sorbitol-6-phosphate dehydrogenase
OS=Malus domestica GN=S6PDH PE=2 SV=1
Length = 310
Score = 158 bits (398), Expect = 9e-038
Identities = 84/244 (34%), Positives = 147/244 (60%), Gaps = 11/244 (4%)
Frame = +2
Query: 74 LRCGKMIPLLGMGTYCPQKDRESTILAVHQAIKIGYRHFDTAKIYGSEEALGTALGQAIS 253
L G +P++G+G + +KD ++ AIKIGYRHFD A Y SE +G AL +A
Sbjct: 6 LSSGYEMPVIGLGLWRLEKDELKEVIL--NAIKIGYRHFDCAAHYKSEADVGEALAEAFK 63
Query: 254 YGTVPREDIFVTSKL*SSDHHDPISALTQTLKTMGLEYLDNYLVHWPIKLKP---GVSEP 424
G V RE++F+T+K+ +SDH + A +L+ + ++YLD YLVH+P+ K G +
Sbjct: 64 TGLVKREELFITTKIWNSDHGHVVEACKNSLEKLQIDYLDLYLVHYPMPTKHNAIGKTAS 123
Query: 425 IPKEE---EFEKDVGIEETWQGMERCLEMGLCRSIGVSNFSSKKIYDLLDFASVYPSVNQ 595
+ E+ + + + +++TW+GME+ + +GL RSIG+SN+ D L ++ + P+V+Q
Sbjct: 124 LLGEDKVLDIDVTISLQQTWEGMEKTVSLGLVRSIGLSNYELFLTRDCLAYSKIKPAVSQ 183
Query: 596 VEMHPLWRQSKLRKVCNENKIHVSGYSPLGGPG---NCWGSTAVIEHPVIKFIALKHSVT 766
E HP +++ L K C ++ + + ++PLGG + +GS + ++ PV+ +A K+ +
Sbjct: 184 FETHPYFQRDSLVKFCMKHGVLPTAHTPLGGAAANKDMFGSVSPLDDPVLNDVAKKYGKS 243
Query: 767 PAQV 778
AQ+
Sbjct: 244 VAQI 247
Database: UniProt/SwissProt
Posted date: Sat Aug 07 14:36:18 2010
Number of letters in database: 182,829,261
Number of sequences in database: 518,415
Lambda K H
0.267 0.041 0.140
Gapped
Lambda K H
0.267 0.041 0.140
Matrix: blosum62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 187,698,552,422
Number of Sequences: 518415
Number of Extensions: 187698552422
Number of Successful Extensions: 1153387334
Number of sequences better than 0.0: 0
|
