BLASTX 7.6.2

Query= UN50865 /QuerySize=1167
        (1166 letters)

Database: UniProt/SwissProt;
          518,415 sequences; 182,829,261 total letters
                                                                  Score    E
Sequences producing significant alignments:                       (bits) Value

sp|Q9NUN7|ACER3_HUMAN Alkaline ceramidase 3 OS=Homo sapiens GN=A...    124   2e-027
sp|P38298|YPC1_YEAST Alkaline ceramidase YPC1 OS=Saccharomyces c...     76   5e-013
sp|Q02896|YDC1_YEAST Alkaline ceramidase YDC1 OS=Saccharomyces c...     74   1e-012
sp|Q8TDN7|ACER1_HUMAN Alkaline ceramidase 1 OS=Homo sapiens GN=A...     61   2e-008
sp|Q8R4X1|ACER1_MOUSE Alkaline ceramidase 1 OS=Mus musculus GN=A...     55   7e-007
sp|Q9VIP7|ACASE_DROME Alkaline ceramidase OS=Drosophila melanoga...     55   9e-007

>sp|Q9NUN7|ACER3_HUMAN Alkaline ceramidase 3 OS=Homo sapiens GN=ACER3 PE=1 SV=3

          Length = 267

 Score =  124 bits (310), Expect = 2e-027
 Identities = 70/258 (27%), Positives = 127/258 (49%), Gaps = 20/258 (7%)
 Frame = -1

Query: 902 FWGPVTSTIECCEKNYAYSSYIAEFYNTISGVPGILLALIGLVNAIRQRFEKRFSILHIS 723
           +WGP TST++ CE+NY+ + YIAEF+NT+S +  I+  + G V ++R   EKR+   +++
Sbjct:  10 YWGPTTSTLDWCEENYSVTWYIAEFWNTVSNLIMIIPPMFGAVQSVRDGLEKRYIASYLA 69

Query: 722 NMILAIGSMLYHATLQHVQQQSDETPMVWEILLYMYILY-------SPDWHYRSTMPTFL 564
             ++ +GS  +H TL++  Q  DE PM++   +++Y ++       S ++H   T    L
Sbjct:  70 LTVVGMGSWCFHMTLKYEMQLLDELPMIYSCCIFVYCMFECFKIKNSVNYHLLFT----L 125

Query: 563 FLYGAAFAAVHAYLTFGIGFKVHYVVLCLLCIPRMYKYYIHTEDTAAKRIAKWYVATILV 384
            L+      V+  +   I  +V Y +L    + R   Y +       + +    +   L+
Sbjct: 126 VLFSLIVTTVYLKVKEPIFHQVMYGMLVFTLVLRSI-YIVTWVYPWLRGLGYTSLGIFLL 184

Query: 383 GSVCWFCDRVFCKTISQW--------SVNPQGHALWHVFMSFNSYCANTFLMFCRAQQRG 228
           G + W  D +FC+++  +         +  Q HA WH+     SY    F ++ R     
Sbjct: 185 GFLFWNIDNIFCESLRNFRKKVPPIIGITTQFHAWWHILTGLGSYLHILFSLYTRTLYLR 244

Query: 227 WNPKVKYFLGVLPYVKIE 174
           + PKVK+  G+ P +  E
Sbjct: 245 YRPKVKFLFGIWPVILFE 262

>sp|P38298|YPC1_YEAST Alkaline ceramidase YPC1 OS=Saccharomyces cerevisiae
        GN=YPC1 PE=1 SV=1

          Length = 316

 Score =  76 bits (185), Expect = 5e-013
 Identities = 36/92 (39%), Positives = 57/92 (61%)
 Frame = -1

Query: 899 WGPVTSTIECCEKNYAYSSYIAEFYNTISGVPGILLALIGLVNAIRQRFEKRFSILHISN 720
           WG  TSTI+ CE+NY  S YIAE+ NT++    IL A+    +A + + EKRF ++    
Sbjct:  17 WGETTSTIDWCEENYVVSPYIAEWSNTLTNSVFILSAIYTTYSAYKNKLEKRFLLIGFGY 76

Query: 719 MILAIGSMLYHATLQHVQQQSDETPMVWEILL 624
            ++ +GS L+H TL++  Q  DE PM++ + +
Sbjct:  77 GLVGVGSWLFHMTLKYRFQLLDELPMIYAMCI 108

>sp|Q02896|YDC1_YEAST Alkaline ceramidase YDC1 OS=Saccharomyces cerevisiae
        GN=YDC1 PE=1 SV=1

          Length = 317

 Score =  74 bits (181), Expect = 1e-012
 Identities = 35/103 (33%), Positives = 61/103 (59%)
 Frame = -1

Query: 911 MSSFWGPVTSTIECCEKNYAYSSYIAEFYNTISGVPGILLALIGLVNAIRQRFEKRFSIL 732
           +  +WG  TS I+ CE+NY  S YIAE+ NTI+    ++ A     +A R + E R+ ++
Sbjct:  12 IEGYWGKPTSLIDWCEENYVVSPYIAEWSNTITNSIFLMTAFYSTYSAWRNKLETRYILI 71

Query: 731 HISNMILAIGSMLYHATLQHVQQQSDETPMVWEILLYMYILYS 603
            +   ++ IGS L+H TLQ+  Q  DE PM++  ++  + +++
Sbjct:  72 GMGFSLVGIGSWLFHMTLQYRYQLLDELPMLYATIIPSWSIFA 114

>sp|Q8TDN7|ACER1_HUMAN Alkaline ceramidase 1 OS=Homo sapiens GN=ACER1 PE=2 SV=1

          Length = 264

 Score =  61 bits (146), Expect = 2e-008
 Identities = 36/118 (30%), Positives = 63/118 (53%), Gaps = 7/118 (5%)
 Frame = -1

Query: 911 MSSFWGPVTSTIECCEKNYAYSSYIAEFYNTISGVPGILLA--LIGLVNAIRQRFEKRFS 738
           M S +   +S ++ CE N+ YS  +AEFYNT S +P  +    ++ L++   Q+  +   
Sbjct:   1 MPSIFAYQSSEVDWCESNFQYSELVAEFYNTFSNIPFFIFGPLMMLLMHPYAQKRSRYIY 60

Query: 737 ILHISNMILAIGSMLYHATLQHVQQQSDETPMVWEILLYMYILYSPDWHYRSTMPTFL 564
           ++ +  MI+ + SM +H TL  + Q  DE  ++W +L   Y ++ P    R   P+FL
Sbjct:  61 VVWVLFMIIGLFSMYFHMTLSFLGQLLDEIAILW-LLGSGYSIWMP----RCYFPSFL 113

>sp|Q8R4X1|ACER1_MOUSE Alkaline ceramidase 1 OS=Mus musculus GN=Acer1 PE=1 SV=1

          Length = 273

 Score =  55 bits (132), Expect = 7e-007
 Identities = 32/110 (29%), Positives = 61/110 (55%), Gaps = 3/110 (2%)
 Frame = -1

Query: 911 MSSFWGPVTSTIECCEKNYAYSSYIAEFYNTISGVPGILLA--LIGLVNAIRQRFEKRFS 738
           MSS +   +S ++ CE N+ +S  +AEFYNT S V  ++    ++ L++   Q+  + F 
Sbjct:  10 MSSIFAYQSSEVDWCESNFQHSELVAEFYNTFSNVFFLIFGPLMMFLMHPYAQKRTRCFY 69

Query: 737 ILHISNMILAIGSMLYHATLQHVQQQSDETPMVWEILLYMYILYSPDWHY 588
            + +  M++ + SM +H TL  + Q  DE  ++W +L   Y ++ P  ++
Sbjct:  70 GVSVLFMLIGLFSMYFHMTLSFLGQLLDEISILW-LLASGYSVWLPRCYF 118

>sp|Q9VIP7|ACASE_DROME Alkaline ceramidase OS=Drosophila melanogaster GN=bwa
        PE=2 SV=2

          Length = 283

 Score =  55 bits (131), Expect = 9e-007
 Identities = 38/121 (31%), Positives = 60/121 (49%), Gaps = 6/121 (4%)
 Frame = -1

Query: 935 GG*KMADGMSSFW---GPVTSTIECCEKNYAYSSYIAEFYNTISGVPGILL--ALIGLVN 771
           GG  + D  +  W    P +S ++ CE NY  SS IAEF NT S    ILL   LI L  
Sbjct:   5 GGGGLLDIYAMAWEHLRPGSSPVDWCEGNYLISSNIAEFVNTFSNFLFILLPPVLIMLFK 64

Query: 770 AIRQRFEKRFSILHISNMILAIGSMLYHATLQHVQQQSDETPMVWEILLYMYILYSPDWH 591
              +       ++ +  +++ + SM +HATL  + Q  DE  ++W + +  + L+ P  +
Sbjct:  65 EYGRFVTPGIHVIWVLLIVVGLSSMYFHATLSLIGQLLDELAILW-VFMAAFSLFYPKRY 123

Query: 590 Y 588
           Y
Sbjct: 124 Y 124

  Database: UniProt/SwissProt
    Posted date:  Sat Aug 07 14:36:18 2010
  Number of letters in database: 182,829,261
  Number of sequences in database:  518,415

Lambda     K     H
   0.267   0.041    0.140
Gapped
Lambda     K     H
   0.267   0.041    0.140
Matrix: blosum62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 191,186,815,274
Number of Sequences: 518415
Number of Extensions: 191186815274
Number of Successful Extensions: 1167985300
Number of sequences better than 0.0: 0