BLASTX 7.6.2
Query= UN50922 /QuerySize=1195
(1194 letters)
Database: UniProt/SwissProt;
518,415 sequences; 182,829,261 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P25807|CPR1_CAEEL Gut-specific cysteine proteinase OS=Caenorh... 235 6e-061
sp|P43157|CYSP_SCHJA Cathepsin B-like cysteine proteinase OS=Sch... 223 3e-057
sp|P25792|CYSP_SCHMA Cathepsin B-like cysteine proteinase OS=Sch... 221 1e-056
sp|P43507|CPR3_CAEEL Cathepsin B-like cysteine proteinase 3 OS=C... 218 1e-055
sp|P25802|CYSP1_OSTOS Cathepsin B-like cysteine proteinase 1 OS=... 201 8e-051
sp|Q54QD9|CTSB_DICDI Cathepsin B OS=Dictyostelium discoideum GN=... 201 1e-050
sp|P43509|CPR5_CAEEL Cathepsin B-like cysteine proteinase 5 OS=C... 171 1e-041
sp|P07858|CATB_HUMAN Cathepsin B OS=Homo sapiens GN=CTSB PE=1 SV=3 171 1e-041
sp|Q4R5M2|CATB_MACFA Cathepsin B OS=Macaca fascicularis GN=CTSB ... 171 1e-041
sp|Q5R6D1|CATB_PONAB Cathepsin B OS=Pongo abelii GN=CTSB PE=2 SV=1 171 1e-041
sp|A1E295|CATB_PIG Cathepsin B OS=Sus scrofa GN=CTSB PE=1 SV=1 169 6e-041
sp|P43508|CPR4_CAEEL Cathepsin B-like cysteine proteinase 4 OS=C... 168 7e-041
sp|P00787|CATB_RAT Cathepsin B OS=Rattus norvegicus GN=Ctsb PE=1... 168 9e-041
sp|P07688|CATB_BOVIN Cathepsin B OS=Bos taurus GN=CTSB PE=1 SV=5 167 2e-040
sp|P10605|CATB_MOUSE Cathepsin B OS=Mus musculus GN=Ctsb PE=1 SV=2 166 3e-040
sp|P43233|CATB_CHICK Cathepsin B OS=Gallus gallus GN=CTSB PE=2 SV=1 163 4e-039
sp|P43510|CPR6_CAEEL Cathepsin B-like cysteine proteinase 6 OS=C... 162 5e-039
sp|P19092|CYSP1_HAECO Cathepsin B-like cysteine proteinase 1 OS=... 151 9e-036
sp|P25793|CYSP2_HAECO Cathepsin B-like cysteine proteinase 2 OS=... 150 2e-035
sp|Q06544|CYSP3_OSTOS Cathepsin B-like cysteine proteinase 3 (Fr... 144 2e-033
>sp|P25807|CPR1_CAEEL Gut-specific cysteine proteinase OS=Caenorhabditis elegans
GN=cpr-1 PE=1 SV=2
Length = 329
Score = 235 bits (598), Expect = 6e-061
Identities = 118/223 (52%), Positives = 142/223 (63%), Gaps = 12/223 (5%)
Frame = +2
Query: 314 DQGHCGSCWAFGAVESLSDRFCI--KYNMNISLSVNDLLACCGFLCGQGCNGGYPISAWR 487
DQ CGSCWAFGA E +SDR CI K +S +DLL+CCG CG GC GGYPI A R
Sbjct: 106 DQATCGSCWAFGAAEMISDRTCIETKGAQQPIISPDDLLSCCGSSCGNGCEGGYPIQALR 165
Query: 488 YFKHHGVVT------EECDPYFDNTGCSHPGCEPAYPTPKCVRKCVSG-NQLWRESKHYG 646
++ GVVT C PY C+ C P TP C C SG + + + KH+G
Sbjct: 166 WWDSKGVVTGGDYHGAGCKPY-PIAPCTSGNC-PESKTPSCSMSCQSGYSTAYAKDKHFG 223
Query: 647 VSAYKVRHDPQDIMAEVYTNGPVEVAFTVYEDFAHYKSGVYKHITGANIGGHAVKLIGWG 826
VSAY V + I AE+Y NGPVE AF+VYEDF YKSGVYKH G +GGHA+K+IGWG
Sbjct: 224 VSAYAVPKNAASIQAEIYANGPVEAAFSVYEDFYKYKSGVYKHTAGKYLGGHAIKIIGWG 283
Query: 827 TSDDGEDYWLLANQWNRSWGDDGYFKIKRGTNECGIEHGVVAG 955
T + G YWL+AN W +WG+ G+FKI RG ++CGIE VVAG
Sbjct: 284 T-ESGSPYWLVANSWGVNWGESGFFKIYRGDDQCGIESAVVAG 325
>sp|P43157|CYSP_SCHJA Cathepsin B-like cysteine proteinase OS=Schistosoma
japonicum GN=CATB PE=2 SV=1
Length = 342
Score = 223 bits (566), Expect = 3e-057
Identities = 117/301 (38%), Positives = 163/301 (54%), Gaps = 56/301 (18%)
Frame = +2
Query: 104 PVVSHDISISLKLPKQFDARTAWSQCSSIGRILGLFFFHFSFHSLLSLCLSLILLT*SFY 283
P V H +++++P QFD+R W C SI
Sbjct: 79 PTVDHH-DLNVEIPSQFDSRKKWPHCKSI------------------------------- 106
Query: 284 VFFHILSSVIDQGHCGSCWAFGAVESLSDRFCIKY--NMNISLSVNDLLACCGFLCGQGC 457
S + DQ CGSCWAFGAVE+++DR CI+ + LS DL++CC CG GC
Sbjct: 107 ------SQIRDQSRCGSCWAFGAVEAMTDRICIQSGGGQSAELSALDLISCCKD-CGDGC 159
Query: 458 NGGYPISAWRYFKHHGVVT-------EECDPY-----FDNTGCSHPGC-EPAYPTPKCVR 598
GG+P AW Y+ G+VT C PY +T +P C Y TP+C +
Sbjct: 160 QGGFPGVAWDYWVKRGIVTGGSKENHTGCQPYPFPKCEHHTKGKYPACGTKIYKTPQCKQ 219
Query: 599 KCVSGNQL-WRESKHYGVSAYKVRHDPQDIMAEVYTNGPVEVAFTVYEDFAHYKSGVYKH 775
C G + + + KHYG +Y V+++ + I ++ GPVE AF VYEDF +YKSG+Y+H
Sbjct: 220 TCQKGYKTPYEQDKHYGDESYNVQNNEKVIQRDIMMYGPVEAAFDVYEDFLNYKSGIYRH 279
Query: 776 ITGANIGGHAVKLIGWGTSDDGEDYWLLANQWNRSWGDDGYFKIKRGTNECGIEHGVVAG 955
+TG+ +GGHA+++IGWG + YWL+AN WN WG+ G F++ RG +EC IE VVAG
Sbjct: 280 VTGSIVGGHAIRIIGWGV-EKRTPYWLIANSWNEDWGEKGLFRMVRGRDECSIESDVVAG 338
Query: 956 L 958
L
Sbjct: 339 L 339
>sp|P25792|CYSP_SCHMA Cathepsin B-like cysteine proteinase OS=Schistosoma
mansoni PE=2 SV=1
Length = 340
Score = 221 bits (561), Expect = 1e-056
Identities = 119/300 (39%), Positives = 163/300 (54%), Gaps = 56/300 (18%)
Frame = +2
Query: 104 PVVSHDISISLKLPKQFDARTAWSQCSSIGRILGLFFFHFSFHSLLSLCLSLILLT*SFY 283
P V H+ ++++P FD+R W C SI
Sbjct: 78 PTVDHN-DWNVEIPSNFDSRKKWPGCKSI------------------------------- 105
Query: 284 VFFHILSSVIDQGHCGSCWAFGAVESLSDRFCIKY--NMNISLSVNDLLACCGFLCGQGC 457
+++ DQ CGSCW+FGAVE++SDR CI+ N+ LS DLL CC CG GC
Sbjct: 106 ------ATIRDQSRCGSCWSFGAVEAMSDRSCIQSGGKQNVELSAVDLLTCCE-SCGLGC 158
Query: 458 NGGYPISAWRYFKHHGVVTEE-------CDPY-----FDNTGCSHPGC-EPAYPTPKCVR 598
GG AW Y+ G+VT C+PY +T +P C Y TP+C +
Sbjct: 159 EGGILGPAWDYWVKEGIVTASSKENHTGCEPYPFPKCEHHTKGKYPPCGSKIYNTPRCKQ 218
Query: 599 KCVSGNQL-WRESKHYGVSAYKVRHDPQDIMAEVYTNGPVEVAFTVYEDFAHYKSGVYKH 775
C + + + KH G S+Y V++D + I E+ GPVE +FTVYEDF +YKSG+YKH
Sbjct: 219 TCQRKYKTPYTQDKHRGKSSYNVKNDEKAIQKEIMKYGPVEASFTVYEDFLNYKSGIYKH 278
Query: 776 ITGANIGGHAVKLIGWGTSDDGEDYWLLANQWNRSWGDDGYFKIKRGTNECGIEHGVVAG 955
ITG +GGHA+++IGWG ++ YWL+AN WN WG++GYF+I RG +EC IE V+AG
Sbjct: 279 ITGEALGGHAIRIIGWGV-ENKTPYWLIANSWNEDWGENGYFRIVRGRDECSIESEVIAG 337
>sp|P43507|CPR3_CAEEL Cathepsin B-like cysteine proteinase 3 OS=Caenorhabditis
elegans GN=cpr-3 PE=2 SV=1
Length = 370
Score = 218 bits (553), Expect = 1e-055
Identities = 113/227 (49%), Positives = 142/227 (62%), Gaps = 16/227 (7%)
Frame = +2
Query: 314 DQGHCGSCWAFGAVESLSDRFCIKYN--MNISLSVNDLLACCGFLCGQGCNGGYPISAWR 487
+Q CGSCWAFGA E +SDR CI+ N +SV D+L+CCG CG GC GGY I A R
Sbjct: 113 NQATCGSCWAFGAAEVISDRVCIQSNGTQQPVISVEDILSCCGTTCGYGCKGGYSIEALR 172
Query: 488 YFKHHGVVT------EECDPYFDNTGCSHPGCEPAYPTPKCVRKCVSG--NQLWRESKHY 643
++ G VT C PY C+ C P TP C C S + +++ KHY
Sbjct: 173 FWASSGAVTGGDYGGHGCMPY-SFAPCT-KNC-PESTTPSCKTTCQSSYKTEEYKKDKHY 229
Query: 644 GVSAYKV--RHDPQDIMAEVYTNGPVEVAFTVYEDFAHYKSGVYKHITGANIGGHAVKLI 817
G SAYKV +I E+Y GPVE ++ VYEDF HYKSGVY + +G +GGHAVK+I
Sbjct: 230 GASAYKVTTTKSVTEIQTEIYHYGPVEASYKVYEDFYHYKSGVYHYTSGKLVGGHAVKII 289
Query: 818 GWGTSDDGEDYWLLANQWNRSWGDDGYFKIKRGTNECGIEHGVVAGL 958
GWG ++G DYWL+AN W S+G+ G+FKI+RGTNEC IE VVAG+
Sbjct: 290 GWGV-ENGVDYWLIANSWGTSFGEKGFFKIRRGTNECQIEGNVVAGI 335
>sp|P25802|CYSP1_OSTOS Cathepsin B-like cysteine proteinase 1 OS=Ostertagia
ostertagi GN=CP-1 PE=3 SV=3
Length = 341
Score = 201 bits (511), Expect = 8e-051
Identities = 99/235 (42%), Positives = 140/235 (59%), Gaps = 19/235 (8%)
Frame = +2
Query: 299 LSSVIDQGHCGSCWAFGAVESLSDRFCI--KYNMNISLSVNDLLACCGFLCGQGCNGGYP 472
L + DQ +CGSCWA + ++SDR CI K + +S D+++CC + CG GC GG+P
Sbjct: 107 LFHIPDQANCGSCWAVSSAAAMSDRICIASKGAKQVLISAQDVVSCCTW-CGDGCEGGWP 165
Query: 473 ISAWRYFKHHGVVT-------EECDPYFDNTGCSHPGCEPAY-------PTPKCVRKCVS 610
ISA+R+ GVVT C PY + C H G E Y TP+C R+C+
Sbjct: 166 ISAFRFHADEGVVTGGDYNTKGSCRPY-EIHPCGHHGNETYYGECVGMADTPRCKRRCLL 224
Query: 611 GNQLWRESKHYGVSAYKVRHDPQDIMAEVYTNGPVEVAFTVYEDFAHYKSGVYKHITGAN 790
G S Y AY++++ + I ++ NGPV +TVYEDFAHY+SG+YKH G
Sbjct: 225 GYPKSYPSDRYYKKAYQLKNSVKAIQKDIMKNGPVVATYTVYEDFAHYRSGIYKHKAGRK 284
Query: 791 IGGHAVKLIGWGTSDDGEDYWLLANQWNRSWGDDGYFKIKRGTNECGIEHGVVAG 955
G HAVK+IGWG + G YW++AN W+ WG++G+F++ RG+N+CG E + AG
Sbjct: 285 TGLHAVKVIGWG-EEKGTPYWIVANSWHDDWGENGFFRMHRGSNDCGFEERMAAG 338
>sp|Q54QD9|CTSB_DICDI Cathepsin B OS=Dictyostelium discoideum GN=ctsB PE=3 SV=1
Length = 311
Score = 201 bits (510), Expect = 1e-050
Identities = 107/227 (47%), Positives = 134/227 (59%), Gaps = 20/227 (8%)
Frame = +2
Query: 299 LSSVIDQGHCGSCWAFGAVESLSDRFCIKYNMNISLSVNDLLACCGFLCGQGCNGGYPIS 478
+S + +Q CGSCWAFGA ES +DR CI N N+ LS D++ C GC GG S
Sbjct: 95 ISQIQNQARCGSCWAFGATESATDRLCIHNNENVQLSFMDMVTCDE--TDNGCEGGDAFS 152
Query: 479 AWRYFKHHGVVTEECDPYFDNTGCSHPGCEPAYP-------TPKCVRKCVSGNQL-WRES 634
AW + + G V+EEC PY + P C PA TP C ++C S + L + +
Sbjct: 153 AWNWLRKQGAVSEECLPY------TIPTCPPAQQPCLNFVNTPSCTKECQSNSSLIYSQD 206
Query: 635 KHYGVSAYKVRHDPQDIMAEVYTNGPVEVAFTVYEDFAHYKSGVYKHITGANIGGHAVKL 814
KH Y D + IM E+ TNGPVE FTV+EDF YKSGVY H TG ++GGH VKL
Sbjct: 207 KHKMAKIYSFDSD-EAIMQEIVTNGPVEACFTVFEDFLAYKSGVYVHTTGKDLGGHCVKL 265
Query: 815 IGWGTSDDGEDYWLLANQWNRSWGDDGYFKIKRGTNECGIEHGVVAG 955
+G+GT +G DY+ NQW SWGD+G F IKRG +CGI VVAG
Sbjct: 266 VGFGTL-NGVDYYAANNQWTTSWGDNGTFLIKRG--DCGISDDVVAG 309
>sp|P43509|CPR5_CAEEL Cathepsin B-like cysteine proteinase 5 OS=Caenorhabditis
elegans GN=cpr-5 PE=1 SV=1
Length = 344
Score = 171 bits (432), Expect = 1e-041
Identities = 79/143 (55%), Positives = 97/143 (67%), Gaps = 5/143 (3%)
Frame = +2
Query: 545 GCSHPGC-EPAYPTPKCVRKCVSGNQL---WRESKHYGVSAYKVRHDPQDIMAEVYTNGP 712
G P C E PTPKCV C S N + + KH+G +AY V + I E+ TNGP
Sbjct: 197 GVKWPACPEDTEPTPKCVDSCTSKNNYATPYLQDKHFGSTAYAVGKKVEQIQTEILTNGP 256
Query: 713 VEVAFTVYEDFAHYKSGVYKHITGANIGGHAVKLIGWGTSDDGEDYWLLANQWNRSWGDD 892
+EVAFTVYEDF Y +GVY H GA++GGHAVK++GWG D+G YWL+AN WN +WG+
Sbjct: 257 IEVAFTVYEDFYQYTTGVYVHTAGASLGGHAVKILGWGV-DNGTPYWLVANSWNVAWGEK 315
Query: 893 GYFKIKRGTNECGIEHGVVAGLP 961
GYF+I RG NECGIEH VAG+P
Sbjct: 316 GYFRIIRGLNECGIEHSAVAGIP 338
>sp|P07858|CATB_HUMAN Cathepsin B OS=Homo sapiens GN=CTSB PE=1 SV=3
Length = 339
Score = 171 bits (431), Expect = 1e-041
Identities = 79/164 (48%), Positives = 106/164 (64%), Gaps = 2/164 (1%)
Frame = +2
Query: 473 ISAWRYFKHHGVVTEECDPYFDNTGCSHPGCEPAYPTPKCVRKCVSG-NQLWRESKHYGV 649
+S Y H G P + S P C TPKC + C G + +++ KHYG
Sbjct: 168 VSGGLYESHVGCRPYSIPPCEHHVNGSRPPCTGEGDTPKCSKICEPGYSPTYKQDKHYGY 227
Query: 650 SAYKVRHDPQDIMAEVYTNGPVEVAFTVYEDFAHYKSGVYKHITGANIGGHAVKLIGWGT 829
++Y V + +DIMAE+Y NGPVE AF+VY DF YKSGVY+H+TG +GGHA++++GWG
Sbjct: 228 NSYSVSNSEKDIMAEIYKNGPVEGAFSVYSDFLLYKSGVYQHVTGEMMGGHAIRILGWGV 287
Query: 830 SDDGEDYWLLANQWNRSWGDDGYFKIKRGTNECGIEHGVVAGLP 961
++G YWL+AN WN WGD+G+FKI RG + CGIE VVAG+P
Sbjct: 288 -ENGTPYWLVANSWNTDWGDNGFFKILRGQDHCGIESEVVAGIP 330
>sp|Q4R5M2|CATB_MACFA Cathepsin B OS=Macaca fascicularis GN=CTSB PE=2 SV=1
Length = 339
Score = 171 bits (431), Expect = 1e-041
Identities = 79/164 (48%), Positives = 106/164 (64%), Gaps = 2/164 (1%)
Frame = +2
Query: 473 ISAWRYFKHHGVVTEECDPYFDNTGCSHPGCEPAYPTPKCVRKCVSG-NQLWRESKHYGV 649
+S Y H G P + S P C TPKC + C G + +++ KHYG
Sbjct: 168 VSGGLYDSHVGCRPYSIPPCEHHVNGSRPPCTGEGDTPKCSKICEPGYSPTYKQDKHYGY 227
Query: 650 SAYKVRHDPQDIMAEVYTNGPVEVAFTVYEDFAHYKSGVYKHITGANIGGHAVKLIGWGT 829
++Y V + +DIMAE+Y NGPVE AF+VY DF YKSGVY+H+TG +GGHA++++GWG
Sbjct: 228 NSYSVSNSEKDIMAEIYKNGPVEGAFSVYSDFLLYKSGVYQHVTGEMMGGHAIRILGWGV 287
Query: 830 SDDGEDYWLLANQWNRSWGDDGYFKIKRGTNECGIEHGVVAGLP 961
++G YWL+AN WN WGD+G+FKI RG + CGIE VVAG+P
Sbjct: 288 -ENGTPYWLVANSWNTDWGDNGFFKILRGQDHCGIESEVVAGIP 330
>sp|Q5R6D1|CATB_PONAB Cathepsin B OS=Pongo abelii GN=CTSB PE=2 SV=1
Length = 339
Score = 171 bits (431), Expect = 1e-041
Identities = 79/164 (48%), Positives = 106/164 (64%), Gaps = 2/164 (1%)
Frame = +2
Query: 473 ISAWRYFKHHGVVTEECDPYFDNTGCSHPGCEPAYPTPKCVRKCVSG-NQLWRESKHYGV 649
+S Y H G P + S P C TPKC + C G + +++ KHYG
Sbjct: 168 VSGGLYESHVGCRPYSIPPCEHHVNGSRPPCTGEGDTPKCSKICEPGYSPTYKQDKHYGY 227
Query: 650 SAYKVRHDPQDIMAEVYTNGPVEVAFTVYEDFAHYKSGVYKHITGANIGGHAVKLIGWGT 829
++Y V + +DIMAE+Y NGPVE AF+VY DF YKSGVY+H+TG +GGHA++++GWG
Sbjct: 228 NSYSVSNSERDIMAEIYKNGPVEGAFSVYSDFLLYKSGVYQHVTGEMMGGHAIRILGWGV 287
Query: 830 SDDGEDYWLLANQWNRSWGDDGYFKIKRGTNECGIEHGVVAGLP 961
++G YWL+AN WN WGD+G+FKI RG + CGIE VVAG+P
Sbjct: 288 -ENGTPYWLVANSWNTDWGDNGFFKILRGQDHCGIESEVVAGIP 330
>sp|A1E295|CATB_PIG Cathepsin B OS=Sus scrofa GN=CTSB PE=1 SV=1
Length = 335
Score = 169 bits (426), Expect = 6e-041
Identities = 77/164 (46%), Positives = 104/164 (63%), Gaps = 2/164 (1%)
Frame = +2
Query: 473 ISAWRYFKHHGVVTEECDPYFDNTGCSHPGCEPAYPTPKCVRKCVSG-NQLWRESKHYGV 649
+S Y H G P + S P C TPKC + C G ++E KH+G
Sbjct: 168 VSGGLYDSHVGCRPYSIPPCEHHVNGSRPPCTGEGDTPKCSKICEPGYTPSYKEDKHFGC 227
Query: 650 SAYKVRHDPQDIMAEVYTNGPVEVAFTVYEDFAHYKSGVYKHITGANIGGHAVKLIGWGT 829
S+Y + + ++IMAE+Y NGPVE AFTVY DF YKSGVY+H+TG +GGHA++++GWG
Sbjct: 228 SSYSISRNEKEIMAEIYKNGPVEGAFTVYSDFLQYKSGVYQHVTGDLMGGHAIRILGWGV 287
Query: 830 SDDGEDYWLLANQWNRSWGDDGYFKIKRGTNECGIEHGVVAGLP 961
++G YWL+ N WN WGD+G+FKI RG + CGIE +VAG+P
Sbjct: 288 -ENGTPYWLVGNSWNTDWGDNGFFKILRGQDHCGIESEIVAGIP 330
>sp|P43508|CPR4_CAEEL Cathepsin B-like cysteine proteinase 4 OS=Caenorhabditis
elegans GN=cpr-4 PE=2 SV=1
Length = 335
Score = 168 bits (425), Expect = 7e-041
Identities = 76/138 (55%), Positives = 96/138 (69%), Gaps = 4/138 (2%)
Frame = +2
Query: 557 PGC-EPAYPTPKCVRKCVSGNQ--LWRESKHYGVSAYKVRHDPQDIMAEVYTNGPVEVAF 727
P C + Y TP CV KC + N + KH+G +AY V I AE+ +GPVE AF
Sbjct: 197 PSCPDDGYDTPACVNKCTNKNYNVAYTADKHFGSTAYAVGKKVSQIQAEIIAHGPVEAAF 256
Query: 728 TVYEDFAHYKSGVYKHITGANIGGHAVKLIGWGTSDDGEDYWLLANQWNRSWGDDGYFKI 907
TVYEDF YK+GVY H TG +GGHA++++GWGT D+G YWL+AN WN +WG++GYF+I
Sbjct: 257 TVYEDFYQYKTGVYVHTTGQELGGHAIRILGWGT-DNGTPYWLVANSWNVNWGENGYFRI 315
Query: 908 KRGTNECGIEHGVVAGLP 961
RGTNECGIEH VV G+P
Sbjct: 316 IRGTNECGIEHAVVGGVP 333
>sp|P00787|CATB_RAT Cathepsin B OS=Rattus norvegicus GN=Ctsb PE=1 SV=2
Length = 339
Score = 168 bits (424), Expect = 9e-041
Identities = 79/164 (48%), Positives = 105/164 (64%), Gaps = 2/164 (1%)
Frame = +2
Query: 473 ISAWRYFKHHGVVTEECDPYFDNTGCSHPGCEPAYPTPKCVRKCVSG-NQLWRESKHYGV 649
+S Y H G + P + S P C TPKC + C +G + ++E KHYG
Sbjct: 168 VSGGVYNSHIGCLPYTIPPCEHHVNGSRPPCTGEGDTPKCNKMCEAGYSTSYKEDKHYGY 227
Query: 650 SAYKVRHDPQDIMAEVYTNGPVEVAFTVYEDFAHYKSGVYKHITGANIGGHAVKLIGWGT 829
++Y V ++IMAE+Y NGPVE AFTV+ DF YKSGVYKH G +GGHA++++GWG
Sbjct: 228 TSYSVSDSEKEIMAEIYKNGPVEGAFTVFSDFLTYKSGVYKHEAGDVMGGHAIRILGWGI 287
Query: 830 SDDGEDYWLLANQWNRSWGDDGYFKIKRGTNECGIEHGVVAGLP 961
++G YWL+AN WN WGD+G+FKI RG N CGIE +VAG+P
Sbjct: 288 -ENGVPYWLVANSWNVDWGDNGFFKILRGENHCGIESEIVAGIP 330
>sp|P07688|CATB_BOVIN Cathepsin B OS=Bos taurus GN=CTSB PE=1 SV=5
Length = 335
Score = 167 bits (421), Expect = 2e-040
Identities = 76/164 (46%), Positives = 106/164 (64%), Gaps = 2/164 (1%)
Frame = +2
Query: 473 ISAWRYFKHHGVVTEECDPYFDNTGCSHPGCEPAYPTPKCVRKCVSG-NQLWRESKHYGV 649
+S Y H G P + S P C TPKC + C G + ++E KH+G
Sbjct: 168 VSGGLYNSHVGCRPYSIPPCEHHVNGSRPPCTGEGDTPKCSKTCEPGYSPSYKEDKHFGC 227
Query: 650 SAYKVRHDPQDIMAEVYTNGPVEVAFTVYEDFAHYKSGVYKHITGANIGGHAVKLIGWGT 829
S+Y V ++ ++IMAE+Y NGPVE AF+VY DF YKSGVY+H++G +GGHA++++GWG
Sbjct: 228 SSYSVANNEKEIMAEIYKNGPVEGAFSVYSDFLLYKSGVYQHVSGEIMGGHAIRILGWGV 287
Query: 830 SDDGEDYWLLANQWNRSWGDDGYFKIKRGTNECGIEHGVVAGLP 961
++G YWL+ N WN WGD+G+FKI RG + CGIE +VAG+P
Sbjct: 288 -ENGTPYWLVGNSWNTDWGDNGFFKILRGQDHCGIESEIVAGMP 330
>sp|P10605|CATB_MOUSE Cathepsin B OS=Mus musculus GN=Ctsb PE=1 SV=2
Length = 339
Score = 166 bits (420), Expect = 3e-040
Identities = 77/164 (46%), Positives = 105/164 (64%), Gaps = 2/164 (1%)
Frame = +2
Query: 473 ISAWRYFKHHGVVTEECDPYFDNTGCSHPGCEPAYPTPKCVRKCVSG-NQLWRESKHYGV 649
+S Y H G + P + S P C TP+C + C +G + ++E KH+G
Sbjct: 168 VSGGVYNSHVGCLPYTIPPCEHHVNGSRPPCTGEGDTPRCNKSCEAGYSPSYKEDKHFGY 227
Query: 650 SAYKVRHDPQDIMAEVYTNGPVEVAFTVYEDFAHYKSGVYKHITGANIGGHAVKLIGWGT 829
++Y V + ++IMAE+Y NGPVE AFTV+ DF YKSGVYKH G +GGHA++++GWG
Sbjct: 228 TSYSVSNSVKEIMAEIYKNGPVEGAFTVFSDFLTYKSGVYKHEAGDMMGGHAIRILGWGV 287
Query: 830 SDDGEDYWLLANQWNRSWGDDGYFKIKRGTNECGIEHGVVAGLP 961
++G YWL AN WN WGD+G+FKI RG N CGIE +VAG+P
Sbjct: 288 -ENGVPYWLAANSWNLDWGDNGFFKILRGENHCGIESEIVAGIP 330
>sp|P43233|CATB_CHICK Cathepsin B OS=Gallus gallus GN=CTSB PE=2 SV=1
Length = 340
Score = 163 bits (410), Expect = 4e-039
Identities = 77/165 (46%), Positives = 103/165 (62%), Gaps = 3/165 (1%)
Frame = +2
Query: 473 ISAWRYFKHHGVVTEECDPYFDNTGCSHPGCE-PAYPTPKCVRKCVSG-NQLWRESKHYG 646
+S Y H G P + S P C TP+C R C G + ++E KHYG
Sbjct: 168 VSGGLYDSHVGCRAYTIPPCEHHVNGSRPPCTGEGGETPRCSRHCEPGYSPSYKEDKHYG 227
Query: 647 VSAYKVRHDPQDIMAEVYTNGPVEVAFTVYEDFAHYKSGVYKHITGANIGGHAVKLIGWG 826
+++Y V ++IMAE+Y NGPVE AF VYEDF YKSGVY+H++G +GGHA++++GWG
Sbjct: 228 ITSYGVPRSEKEIMAEIYKNGPVEGAFIVYEDFLMYKSGVYQHVSGEQVGGHAIRILGWG 287
Query: 827 TSDDGEDYWLLANQWNRSWGDDGYFKIKRGTNECGIEHGVVAGLP 961
++G YWL AN WN WG G+FKI RG + CGIE +VAG+P
Sbjct: 288 V-ENGTPYWLAANSWNTDWGITGFFKILRGEDHCGIESEIVAGVP 331
>sp|P43510|CPR6_CAEEL Cathepsin B-like cysteine proteinase 6 OS=Caenorhabditis
elegans GN=cpr-6 PE=1 SV=1
Length = 379
Score = 162 bits (409), Expect = 5e-039
Identities = 75/131 (57%), Positives = 93/131 (70%), Gaps = 3/131 (2%)
Frame = +2
Query: 575 YPTPKCVRKCVSG--NQLWRESKHYGVSAYKVRHDPQDIMAEVYTNGPVEVAFTVYEDFA 748
YPTPKC +KCVS ++ + E K +G SAY V+ D + I E+ T+GP+E+AF VYEDF
Sbjct: 228 YPTPKCEKKCVSDYTDKTYSEDKFFGASAYGVKDDVEAIQKELMTHGPLEIAFEVYEDFL 287
Query: 749 HYKSGVYKHITGANIGGHAVKLIGWGTSDDGEDYWLLANQWNRSWGDDGYFKIKRGTNEC 928
+Y GVY H G GGHAVKLIGWG DDG YW +AN WN WG+DG+F+I RG +EC
Sbjct: 288 NYDGGVYVHTGGKLGGGHAVKLIGWGI-DDGIPYWTVANSWNTDWGEDGFFRILRGVDEC 346
Query: 929 GIEHGVVAGLP 961
GIE GVV G+P
Sbjct: 347 GIESGVVGGIP 357
>sp|P19092|CYSP1_HAECO Cathepsin B-like cysteine proteinase 1 OS=Haemonchus
contortus GN=AC-1 PE=2 SV=1
Length = 342
Score = 151 bits (381), Expect = 9e-036
Identities = 68/133 (51%), Positives = 89/133 (66%), Gaps = 2/133 (1%)
Frame = +2
Query: 563 CEPAYPTPKCVRKCVSG-NQLWRESKHYGVSAYKVRHDPQDIMAEVYTNGPVEVAFTVYE 739
C PTP C RKC G +++R K YG AY V+ + I +E+ NGPV +F VYE
Sbjct: 205 CRGTAPTPPCKRKCRPGVRKMYRIDKRYGKDAYIVKQSVKAIQSEILRNGPVVASFAVYE 264
Query: 740 DFAHYKSGVYKHITGANIGGHAVKLIGWGTSDDGEDYWLLANQWNRSWGDDGYFKIKRGT 919
DF HYKSG+YKH G G HAVK+IGWG +++ D+WL+AN W+ WG+ GYF+I RGT
Sbjct: 265 DFRHYKSGIYKHTAGELRGYHAVKMIGWG-NENNTDFWLIANSWHNDWGEKGYFRIIRGT 323
Query: 920 NECGIEHGVVAGL 958
N+CGIE + AG+
Sbjct: 324 NDCGIEGTIAAGI 336
>sp|P25793|CYSP2_HAECO Cathepsin B-like cysteine proteinase 2 OS=Haemonchus
contortus GN=AC-2 PE=2 SV=1
Length = 342
Score = 150 bits (378), Expect = 2e-035
Identities = 67/133 (50%), Positives = 89/133 (66%), Gaps = 2/133 (1%)
Frame = +2
Query: 563 CEPAYPTPKCVRKCVSG-NQLWRESKHYGVSAYKVRHDPQDIMAEVYTNGPVEVAFTVYE 739
C PTP C RKC G +++R K YG AY V+ + I +E+ NGPV +F VYE
Sbjct: 205 CRGTAPTPPCKRKCRPGVRKMYRIDKRYGKDAYIVKQSVKAIQSEILKNGPVVASFAVYE 264
Query: 740 DFAHYKSGVYKHITGANIGGHAVKLIGWGTSDDGEDYWLLANQWNRSWGDDGYFKIKRGT 919
DF HYKSG+YKH G G HAVK+IGWG +++ D+WL+AN W+ WG+ GYF+I RG+
Sbjct: 265 DFRHYKSGIYKHTAGELRGYHAVKMIGWG-NENNTDFWLIANSWHNDWGEKGYFRIVRGS 323
Query: 920 NECGIEHGVVAGL 958
N+CGIE + AG+
Sbjct: 324 NDCGIEGTIAAGI 336
>sp|Q06544|CYSP3_OSTOS Cathepsin B-like cysteine proteinase 3 (Fragment)
OS=Ostertagia ostertagi GN=CP-3 PE=3 SV=1
Length = 174
Score = 144 bits (361), Expect = 2e-033
Identities = 64/133 (48%), Positives = 87/133 (65%), Gaps = 2/133 (1%)
Frame = +2
Query: 563 CEPAYPTPKCVRKCVSGN-QLWRESKHYGVSAYKVRHDPQDIMAEVYTNGPVEVAFTVYE 739
C TPKC + C G + ++E KH+G SAY++ ++ + I ++ NGPV F VYE
Sbjct: 42 CYDTAKTPKCQKTCQRGYLKAYKEDKHFGKSAYRLPNNVKAIQRDIMKNGPVVAGFIVYE 101
Query: 740 DFAHYKSGVYKHITGANIGGHAVKLIGWGTSDDGEDYWLLANQWNRSWGDDGYFKIKRGT 919
DFAHYKSG+YKH G GGHAVK+IGWG + G YWL+AN W+ WG+ G++++ RG
Sbjct: 102 DFAHYKSGIYKHTAGRMTGGHAVKIIGWG-KEKGTPYWLIANSWHDDWGEKGFYRMIRGI 160
Query: 920 NECGIEHGVVAGL 958
N C IE V AG+
Sbjct: 161 NNCRIEEMVFAGI 173
Database: UniProt/SwissProt
Posted date: Sat Aug 07 14:36:18 2010
Number of letters in database: 182,829,261
Number of sequences in database: 518,415
Lambda K H
0.267 0.041 0.140
Gapped
Lambda K H
0.267 0.041 0.140
Matrix: blosum62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 191,186,815,274
Number of Sequences: 518415
Number of Extensions: 191186815274
Number of Successful Extensions: 1167985300
Number of sequences better than 0.0: 0
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