BLASTX 7.6.2

Query= UN56613 /QuerySize=638
        (637 letters)

Database: UniProt/SwissProt;
          518,415 sequences; 182,829,261 total letters
                                                                  Score    E
Sequences producing significant alignments:                       (bits) Value

sp|Q9NUN7|ACER3_HUMAN Alkaline ceramidase 3 OS=Homo sapiens GN=A...     90   9e-018
sp|P38298|YPC1_YEAST Alkaline ceramidase YPC1 OS=Saccharomyces c...     76   2e-013
sp|Q02896|YDC1_YEAST Alkaline ceramidase YDC1 OS=Saccharomyces c...     74   5e-013
sp|Q8TDN7|ACER1_HUMAN Alkaline ceramidase 1 OS=Homo sapiens GN=A...     61   6e-009
sp|Q8R4X1|ACER1_MOUSE Alkaline ceramidase 1 OS=Mus musculus GN=A...     55   3e-007
sp|Q9VIP7|ACASE_DROME Alkaline ceramidase OS=Drosophila melanoga...     55   3e-007

>sp|Q9NUN7|ACER3_HUMAN Alkaline ceramidase 3 OS=Homo sapiens GN=ACER3 PE=1 SV=3

          Length = 267

 Score =  90 bits (222), Expect = 9e-018
 Identities = 41/130 (31%), Positives = 76/130 (58%), Gaps = 7/130 (5%)
 Frame = +2

Query: 248 FWGPVTSTIECCEKNYAYSSYIAEFYNTISGVPGILLALIGLVNAIRQRFEKRFSILHIS 427
           +WGP TST++ CE+NY+ + YIAEF+NT+S +  I+  + G V ++R   EKR+   +++
Sbjct:  10 YWGPTTSTLDWCEENYSVTWYIAEFWNTVSNLIMIIPPMFGAVQSVRDGLEKRYIASYLA 69

Query: 428 NMILAIGSMLYHATLQHVQQQSDETPMVWEILLYMYILY-------SPDWHYRSTMPTFL 586
             ++ +GS  +H TL++  Q  DE PM++   +++Y ++       S ++H   T+  F 
Sbjct:  70 LTVVGMGSWCFHMTLKYEMQLLDELPMIYSCCIFVYCMFECFKIKNSVNYHLLFTLVLFS 129

Query: 587 FLYGAAFAAV 616
            +    +  V
Sbjct: 130 LIVTTVYLKV 139

>sp|P38298|YPC1_YEAST Alkaline ceramidase YPC1 OS=Saccharomyces cerevisiae
        GN=YPC1 PE=1 SV=1

          Length = 316

 Score =  76 bits (185), Expect = 2e-013
 Identities = 36/92 (39%), Positives = 57/92 (61%)
 Frame = +2

Query: 251 WGPVTSTIECCEKNYAYSSYIAEFYNTISGVPGILLALIGLVNAIRQRFEKRFSILHISN 430
           WG  TSTI+ CE+NY  S YIAE+ NT++    IL A+    +A + + EKRF ++    
Sbjct:  17 WGETTSTIDWCEENYVVSPYIAEWSNTLTNSVFILSAIYTTYSAYKNKLEKRFLLIGFGY 76

Query: 431 MILAIGSMLYHATLQHVQQQSDETPMVWEILL 526
            ++ +GS L+H TL++  Q  DE PM++ + +
Sbjct:  77 GLVGVGSWLFHMTLKYRFQLLDELPMIYAMCI 108

>sp|Q02896|YDC1_YEAST Alkaline ceramidase YDC1 OS=Saccharomyces cerevisiae
        GN=YDC1 PE=1 SV=1

          Length = 317

 Score =  74 bits (181), Expect = 5e-013
 Identities = 35/103 (33%), Positives = 61/103 (59%)
 Frame = +2

Query: 239 MSSFWGPVTSTIECCEKNYAYSSYIAEFYNTISGVPGILLALIGLVNAIRQRFEKRFSIL 418
           +  +WG  TS I+ CE+NY  S YIAE+ NTI+    ++ A     +A R + E R+ ++
Sbjct:  12 IEGYWGKPTSLIDWCEENYVVSPYIAEWSNTITNSIFLMTAFYSTYSAWRNKLETRYILI 71

Query: 419 HISNMILAIGSMLYHATLQHVQQQSDETPMVWEILLYMYILYS 547
            +   ++ IGS L+H TLQ+  Q  DE PM++  ++  + +++
Sbjct:  72 GMGFSLVGIGSWLFHMTLQYRYQLLDELPMLYATIIPSWSIFA 114

>sp|Q8TDN7|ACER1_HUMAN Alkaline ceramidase 1 OS=Homo sapiens GN=ACER1 PE=2 SV=1

          Length = 264

 Score =  61 bits (146), Expect = 6e-009
 Identities = 36/118 (30%), Positives = 63/118 (53%), Gaps = 7/118 (5%)
 Frame = +2

Query: 239 MSSFWGPVTSTIECCEKNYAYSSYIAEFYNTISGVPGILLA--LIGLVNAIRQRFEKRFS 412
           M S +   +S ++ CE N+ YS  +AEFYNT S +P  +    ++ L++   Q+  +   
Sbjct:   1 MPSIFAYQSSEVDWCESNFQYSELVAEFYNTFSNIPFFIFGPLMMLLMHPYAQKRSRYIY 60

Query: 413 ILHISNMILAIGSMLYHATLQHVQQQSDETPMVWEILLYMYILYSPDWHYRSTMPTFL 586
           ++ +  MI+ + SM +H TL  + Q  DE  ++W +L   Y ++ P    R   P+FL
Sbjct:  61 VVWVLFMIIGLFSMYFHMTLSFLGQLLDEIAILW-LLGSGYSIWMP----RCYFPSFL 113

>sp|Q8R4X1|ACER1_MOUSE Alkaline ceramidase 1 OS=Mus musculus GN=Acer1 PE=1 SV=1

          Length = 273

 Score =  55 bits (132), Expect = 3e-007
 Identities = 32/110 (29%), Positives = 61/110 (55%), Gaps = 3/110 (2%)
 Frame = +2

Query: 239 MSSFWGPVTSTIECCEKNYAYSSYIAEFYNTISGVPGILLA--LIGLVNAIRQRFEKRFS 412
           MSS +   +S ++ CE N+ +S  +AEFYNT S V  ++    ++ L++   Q+  + F 
Sbjct:  10 MSSIFAYQSSEVDWCESNFQHSELVAEFYNTFSNVFFLIFGPLMMFLMHPYAQKRTRCFY 69

Query: 413 ILHISNMILAIGSMLYHATLQHVQQQSDETPMVWEILLYMYILYSPDWHY 562
            + +  M++ + SM +H TL  + Q  DE  ++W +L   Y ++ P  ++
Sbjct:  70 GVSVLFMLIGLFSMYFHMTLSFLGQLLDEISILW-LLASGYSVWLPRCYF 118

>sp|Q9VIP7|ACASE_DROME Alkaline ceramidase OS=Drosophila melanogaster GN=bwa
        PE=2 SV=2

          Length = 283

 Score =  55 bits (131), Expect = 3e-007
 Identities = 38/121 (31%), Positives = 60/121 (49%), Gaps = 6/121 (4%)
 Frame = +2

Query: 215 GG*KMADGMSSFW---GPVTSTIECCEKNYAYSSYIAEFYNTISGVPGILL--ALIGLVN 379
           GG  + D  +  W    P +S ++ CE NY  SS IAEF NT S    ILL   LI L  
Sbjct:   5 GGGGLLDIYAMAWEHLRPGSSPVDWCEGNYLISSNIAEFVNTFSNFLFILLPPVLIMLFK 64

Query: 380 AIRQRFEKRFSILHISNMILAIGSMLYHATLQHVQQQSDETPMVWEILLYMYILYSPDWH 559
              +       ++ +  +++ + SM +HATL  + Q  DE  ++W + +  + L+ P  +
Sbjct:  65 EYGRFVTPGIHVIWVLLIVVGLSSMYFHATLSLIGQLLDELAILW-VFMAAFSLFYPKRY 123

Query: 560 Y 562
           Y
Sbjct: 124 Y 124

  Database: UniProt/SwissProt
    Posted date:  Sat Aug 07 14:36:18 2010
  Number of letters in database: 182,829,261
  Number of sequences in database:  518,415

Lambda     K     H
   0.267   0.041    0.140
Gapped
Lambda     K     H
   0.267   0.041    0.140
Matrix: blosum62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 203,055,350,260
Number of Sequences: 518415
Number of Extensions: 203055350260
Number of Successful Extensions: 1243317088
Number of sequences better than 0.0: 0