BLASTX 7.6.2
Query= UN58809 /QuerySize=663
(662 letters)
Database: UniProt/SwissProt;
518,415 sequences; 182,829,261 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q84WW6|ASHH1_ARATH Histone-lysine N-methyltransferase ASHH1 O... 286 1e-076
sp|Q2LAE1|ASHH2_ARATH Histone-lysine N-methyltransferase ASHH2 O... 97 6e-020
sp|Q6BM04|SET2_DEBHA Histone-lysine N-methyltransferase, H3 lysi... 84 7e-016
sp|Q99MY8|ASH1L_MOUSE Probable histone-lysine N-methyltransferas... 81 5e-015
sp|Q8BVE8|NSD2_MOUSE Probable histone-lysine N-methyltransferase... 81 6e-015
sp|O96028|NSD2_HUMAN Probable histone-lysine N-methyltransferase... 79 2e-014
sp|Q9NR48|ASH1L_HUMAN Probable histone-lysine N-methyltransferas... 78 5e-014
sp|Q1DU03|SET2_COCIM Histone-lysine N-methyltransferase, H3 lysi... 78 5e-014
sp|Q5ASA5|SET2_EMENI Histone-lysine N-methyltransferase, H3 lysi... 78 5e-014
sp|Q59XV0|SET2_CANAL Histone-lysine N-methyltransferase, H3 lysi... 77 9e-014
sp|Q5KDJ0|SET2_CRYNE Histone-lysine N-methyltransferase, H3 lysi... 77 1e-013
sp|Q9H5I1|SUV92_HUMAN Histone-lysine N-methyltransferase SUV39H2... 54 1e-006
sp|Q4R3E0|SUV92_MACFA Histone-lysine N-methyltransferase SUV39H2... 54 1e-006
sp|Q28CQ7|SUV92_XENTR Histone-lysine N-methyltransferase SUV39H2... 52 4e-006
sp|Q32PH7|SUV92_BOVIN Histone-lysine N-methyltransferase SUV39H2... 51 7e-006
sp|Q9EQQ0|SUV92_MOUSE Histone-lysine N-methyltransferase SUV39H2... 50 9e-006
>sp|Q84WW6|ASHH1_ARATH Histone-lysine N-methyltransferase ASHH1 OS=Arabidopsis
thaliana GN=ASHH1 PE=2 SV=1
Length = 492
Score = 286 bits (730), Expect = 1e-076
Identities = 130/139 (93%), Positives = 135/139 (97%), Gaps = 3/139 (2%)
Frame = +1
Query: 199 MQFSCDPDQEGDELPQYEHIYQNDFSYRKHKKQKEEDISICECKFDFGDPDSACGERCLN 378
MQFSCDPDQEGDELPQYEHIYQNDFSYRKHKKQKEEDISICECKFDFGDPDSACGERCLN
Sbjct: 1 MQFSCDPDQEGDELPQYEHIYQNDFSYRKHKKQKEEDISICECKFDFGDPDSACGERCLN 60
Query: 379 VITNTECTPGYCPCGVYCKNQKFQKCEYAKTKLIKSEGRGYGLVAVEDIK---FIIEYCG 549
VITNTECTPGYCPCGVYCKNQKFQKCEYAKTKLIK EGRG+GLVA+E+IK FI+EYCG
Sbjct: 61 VITNTECTPGYCPCGVYCKNQKFQKCEYAKTKLIKCEGRGWGLVALEEIKAGQFIMEYCG 120
Query: 550 EVISWKEAKRRAQTYETHG 606
EVISWKEAK+RAQTYETHG
Sbjct: 121 EVISWKEAKKRAQTYETHG 139
>sp|Q2LAE1|ASHH2_ARATH Histone-lysine N-methyltransferase ASHH2 OS=Arabidopsis
thaliana GN=ASHH2 PE=2 SV=1
Length = 1759
Score = 97 bits (241), Expect = 6e-020
Identities = 51/133 (38%), Positives = 74/133 (55%), Gaps = 8/133 (6%)
Frame = +1
Query: 229 GDELPQYEHIYQNDFSYRKHKKQKEEDISICECKFDFGDPDS--ACGERCLNVITNTECT 402
G + ++ I N F +R K Q ++I +C CK PD CGE CLN + N EC
Sbjct: 949 GKQKACFKAIKTNQFLHRNRKSQTIDEIMVCHCK---PSPDGRLGCGEECLNRMLNIECL 1005
Query: 403 PGYCPCGVYCKNQKFQKCEYAKTKLIKSEGRGYGLVAVEDIK---FIIEYCGEVISWKEA 573
G CP G C NQ+FQK +Y K + +S +GYGL +ED++ F+IEY GEV+ +
Sbjct: 1006 QGTCPAGDLCSNQQFQKRKYVKFERFQSGKKGYGLRLLEDVREGQFLIEYVGEVLDMQSY 1065
Query: 574 KRRAQTYETHGKQ 612
+ R + Y G++
Sbjct: 1066 ETRQKEYAFKGQK 1078
>sp|Q6BM04|SET2_DEBHA Histone-lysine N-methyltransferase, H3 lysine-36 specific
OS=Debaryomyces hansenii GN=SET2 PE=3 SV=2
Length = 731
Score = 84 bits (206), Expect = 7e-016
Identities = 46/135 (34%), Positives = 74/135 (54%), Gaps = 8/135 (5%)
Frame = +1
Query: 220 DQEGDELPQYEHIYQNDFSYRKHKKQKEEDISICECKFDFG---DPDSACGE--RCLNVI 384
D+ + + + + +S + + + C+C D+ + ACGE C+N +
Sbjct: 24 DKTDEARSTFNELQECTYSSKSTGSSGQHEHMTCDCYEDWDSDKQQNMACGEDSDCINRV 83
Query: 385 TNTECTPGYCPCGVYCKNQKFQKCEYAKTKLIKSEGRGYGLVAVEDI---KFIIEYCGEV 555
T+ EC+ +C CG C+NQ+FQK +YA +I++E +GYGL A EDI FI EY GEV
Sbjct: 84 TSVECSNKFCTCGNDCQNQRFQKKQYANVTVIQTELKGYGLRANEDISESSFIYEYIGEV 143
Query: 556 ISWKEAKRRAQTYET 600
I + ++R Y+T
Sbjct: 144 IDEESFRKRMIDYDT 158
>sp|Q99MY8|ASH1L_MOUSE Probable histone-lysine N-methyltransferase ASH1L OS=Mus
musculus GN=Ash1l PE=1 SV=2
Length = 2958
Score = 81 bits (199), Expect = 5e-015
Identities = 46/134 (34%), Positives = 70/134 (52%), Gaps = 7/134 (5%)
Frame = +1
Query: 235 ELPQYEHIYQNDFSYRKHKKQKEEDISICECKFDFGDPDSACGERCLNVITNTECTPGYC 414
++P Y+ I N Y K + + C CK D CG+ CLN + EC+P C
Sbjct: 2060 DVPLYKKIRSN--VYVDVKPLSGYEATTCNCKKPDDDTRKGCGDDCLNRMIFAECSPNTC 2117
Query: 415 PCGVYCKNQKFQKCEYAK-TKLIKSEGRGYGLVAVEDIK---FIIEYCGEVISWKEAKRR 582
PCG C NQ+ Q+ E+ + + ++E +G+G+ E +K FIIEY GEV+S +E + R
Sbjct: 2118 PCGEQCCNQRIQRHEWVQCLERFRAEEKGWGIRTKEPLKAGQFIIEYLGEVVSEQEFRNR 2177
Query: 583 -AQTYETHGKQRCV 621
+ Y H C+
Sbjct: 2178 MIEQYHNHSDHYCL 2191
>sp|Q8BVE8|NSD2_MOUSE Probable histone-lysine N-methyltransferase NSD2 OS=Mus
musculus GN=Whsc1 PE=2 SV=2
Length = 1365
Score = 81 bits (198), Expect = 6e-015
Identities = 49/121 (40%), Positives = 68/121 (56%), Gaps = 11/121 (9%)
Frame = +1
Query: 241 PQYEHIYQNDFSYRKHKKQKEE--DISICECKFDFGDPDSACG--ERCLNVITNTECTPG 408
P Y+HI N Y K + + +I C CK ++ CG CLN + EC P
Sbjct: 989 PPYKHIKVNK-PYGKVQIYTADISEIPKCNCK---PTDENPCGSDSECLNRMLMFECHPQ 1044
Query: 409 YCPCGVYCKNQKFQKCEYAKTKLIKSEGRGYGLVAVEDIK---FIIEYCGEVISWKEAKR 579
CP G YC+NQ F K +Y +TK+IK++G+G+GLVA DI+ F+ EY GE+I +E
Sbjct: 1045 VCPAGEYCQNQCFTKRQYPETKIIKTDGKGWGLVAKRDIRKGEFVNEYVGELIDEEECMA 1104
Query: 580 R 582
R
Sbjct: 1105 R 1105
>sp|O96028|NSD2_HUMAN Probable histone-lysine N-methyltransferase NSD2 OS=Homo
sapiens GN=WHSC1 PE=1 SV=1
Length = 1365
Score = 79 bits (194), Expect = 2e-014
Identities = 48/121 (39%), Positives = 68/121 (56%), Gaps = 11/121 (9%)
Frame = +1
Query: 241 PQYEHIYQNDFSYRKHKKQKEE--DISICECKFDFGDPDSACG--ERCLNVITNTECTPG 408
P Y+HI N Y K + + +I C CK ++ CG CLN + EC P
Sbjct: 989 PPYKHIKVNK-PYGKVQIYTADISEIPKCNCK---PTDENPCGFDSECLNRMLMFECHPQ 1044
Query: 409 YCPCGVYCKNQKFQKCEYAKTKLIKSEGRGYGLVAVEDIK---FIIEYCGEVISWKEAKR 579
CP G +C+NQ F K +Y +TK+IK++G+G+GLVA DI+ F+ EY GE+I +E
Sbjct: 1045 VCPAGEFCQNQCFTKRQYPETKIIKTDGKGWGLVAKRDIRKGEFVNEYVGELIDEEECMA 1104
Query: 580 R 582
R
Sbjct: 1105 R 1105
>sp|Q9NR48|ASH1L_HUMAN Probable histone-lysine N-methyltransferase ASH1L OS=Homo
sapiens GN=ASH1L PE=1 SV=2
Length = 2969
Score = 78 bits (190), Expect = 5e-014
Identities = 45/134 (33%), Positives = 69/134 (51%), Gaps = 7/134 (5%)
Frame = +1
Query: 235 ELPQYEHIYQNDFSYRKHKKQKEEDISICECKFDFGDPDSACGERCLNVITNTECTPGYC 414
++P Y+ I N Y K + + C CK D C + CLN + EC+P C
Sbjct: 2070 DVPLYKKIRSN--VYVDVKPLSGYEATTCNCKKPDDDTRKGCVDDCLNRMIFAECSPNTC 2127
Query: 415 PCGVYCKNQKFQKCEYAK-TKLIKSEGRGYGLVAVEDIK---FIIEYCGEVISWKEAKRR 582
PCG C NQ+ Q+ E+ + + ++E +G+G+ E +K FIIEY GEV+S +E + R
Sbjct: 2128 PCGEQCCNQRIQRHEWVQCLERFRAEEKGWGIRTKEPLKAGQFIIEYLGEVVSEQEFRNR 2187
Query: 583 -AQTYETHGKQRCV 621
+ Y H C+
Sbjct: 2188 MIEQYHNHSDHYCL 2201
>sp|Q1DU03|SET2_COCIM Histone-lysine N-methyltransferase, H3 lysine-36 specific
OS=Coccidioides immitis GN=SET2 PE=3 SV=1
Length = 1003
Score = 78 bits (190), Expect = 5e-014
Identities = 45/101 (44%), Positives = 61/101 (60%), Gaps = 11/101 (10%)
Frame = +1
Query: 319 CECKFDFGDPDSACGE--RCLNVITNTECTPGYCPCGVYCKNQKFQKCEYAKTKLIKSEG 492
C+C ++ ACGE C+N T EC G C CG C+NQ+FQ+ EYAK +IK+E
Sbjct: 151 CDCAEEW-----ACGEDSDCINRATKMECF-GDCGCGDSCQNQRFQRREYAKVSVIKTEK 204
Query: 493 RGYGLVAVEDIK---FIIEYCGEVISWKEAKRRAQTYETHG 606
+GYGL A D++ FI EY GEVI+ + +RR Y+ G
Sbjct: 205 KGYGLRADCDLRPNEFIFEYIGEVINEPQFRRRMIQYDEEG 245
>sp|Q5ASA5|SET2_EMENI Histone-lysine N-methyltransferase, H3 lysine-36 specific
OS=Emericella nidulans GN=set2 PE=3 SV=1
Length = 980
Score = 78 bits (190), Expect = 5e-014
Identities = 43/89 (48%), Positives = 55/89 (61%), Gaps = 6/89 (6%)
Frame = +1
Query: 355 ACGE--RCLNVITNTECTPGYCPCGVYCKNQKFQKCEYAKTKLIKSEGRGYGLVAVEDIK 528
ACGE C+N T EC G C CG C+NQ+FQ+ EYA +IK+E +GYGL A ED++
Sbjct: 204 ACGEDSDCINRATKIECM-GDCGCGPDCQNQRFQRREYANVAVIKTEKKGYGLRAEEDLR 262
Query: 529 ---FIIEYCGEVISWKEAKRRAQTYETHG 606
FI EY GEVI+ RR + Y+ G
Sbjct: 263 PHQFIFEYVGEVINEGPFHRRMRQYDAEG 291
>sp|Q59XV0|SET2_CANAL Histone-lysine N-methyltransferase, H3 lysine-36 specific
OS=Candida albicans GN=SET2 PE=3 SV=1
Length = 844
Score = 77 bits (188), Expect = 9e-014
Identities = 44/116 (37%), Positives = 71/116 (61%), Gaps = 9/116 (7%)
Frame = +1
Query: 274 SYRKHKKQKEEDISICECKFDFGDP---DSACG--ERCLNVITNTECTPGYCPCGVYCKN 438
S+++ ++K E ++ C+C+ ++ + ACG C+N IT EC C CG C+N
Sbjct: 75 SHQQQHRRKLEYMT-CDCEEEWDSELQMNLACGPDSNCINRITCVECVNRNCLCGDDCQN 133
Query: 439 QKFQKCEYAKTKLIKSEGRGYGLVAVEDI---KFIIEYCGEVISWKEAKRRAQTYE 597
Q+FQ +Y+K K+I++E +GYGL+A +DI +FI EY GEVI ++R Y+
Sbjct: 134 QRFQNRQYSKVKVIQTELKGYGLIAEQDIEENQFIYEYIGEVIDEISFRQRMIEYD 189
>sp|Q5KDJ0|SET2_CRYNE Histone-lysine N-methyltransferase, H3 lysine-36 specific
OS=Cryptococcus neoformans GN=SET2 PE=3 SV=1
Length = 834
Score = 77 bits (187), Expect = 1e-013
Identities = 40/110 (36%), Positives = 61/110 (55%), Gaps = 6/110 (5%)
Frame = +1
Query: 295 QKEEDISICECKFDFGDPDS-ACG--ERCLNVITNTECTPGYCPCGVYCKNQKFQKCEYA 465
++ +++ +CEC ++ DPD+ CG C+N EC G C G +C NQ+F K +YA
Sbjct: 122 KENDEMMVCECVYNRHDPDADPCGPDSDCINRALYIECIAGECRAGKHCHNQQFSKRQYA 181
Query: 466 KTKLIKSEGRGYGLVAVEDI---KFIIEYCGEVISWKEAKRRAQTYETHG 606
++ +E +GYGL A I I EY GEV++ K ++R Q Y G
Sbjct: 182 NVDVVLTEKKGYGLRASSTIPANTLIYEYIGEVVAEKTFRKRMQQYADEG 231
>sp|Q9H5I1|SUV92_HUMAN Histone-lysine N-methyltransferase SUV39H2 OS=Homo
sapiens GN=SUV39H2 PE=1 SV=2
Length = 410
Score = 54 bits (127), Expect = 1e-006
Identities = 29/69 (42%), Positives = 42/69 (60%), Gaps = 4/69 (5%)
Frame = +1
Query: 412 CPCGVYCKNQKFQK-CEYAKTKLIKSEGRGYG---LVAVEDIKFIIEYCGEVISWKEAKR 579
C CG C N+ QK +Y+ S GRG+G LV ++ + F++EY GEVI+ +EA+R
Sbjct: 233 CQCGPDCPNRIVQKGTQYSLCIFRTSNGRGWGVKTLVKIKRMSFVMEYVGEVITSEEAER 292
Query: 580 RAQTYETHG 606
R Q Y+ G
Sbjct: 293 RGQFYDNKG 301
>sp|Q4R3E0|SUV92_MACFA Histone-lysine N-methyltransferase SUV39H2 OS=Macaca
fascicularis GN=SUV39H2 PE=2 SV=2
Length = 410
Score = 54 bits (127), Expect = 1e-006
Identities = 29/69 (42%), Positives = 42/69 (60%), Gaps = 4/69 (5%)
Frame = +1
Query: 412 CPCGVYCKNQKFQK-CEYAKTKLIKSEGRGYG---LVAVEDIKFIIEYCGEVISWKEAKR 579
C CG C N+ QK +Y+ S GRG+G LV ++ + F++EY GEVI+ +EA+R
Sbjct: 233 CQCGPDCPNRIVQKGTQYSLCIFRTSNGRGWGVKTLVKIKRMSFVMEYVGEVITSEEAER 292
Query: 580 RAQTYETHG 606
R Q Y+ G
Sbjct: 293 RGQFYDNKG 301
>sp|Q28CQ7|SUV92_XENTR Histone-lysine N-methyltransferase SUV39H2 OS=Xenopus
tropicalis GN=suv39h2 PE=2 SV=2
Length = 406
Score = 52 bits (122), Expect = 4e-006
Identities = 28/69 (40%), Positives = 41/69 (59%), Gaps = 4/69 (5%)
Frame = +1
Query: 412 CPCGVYCKNQKFQK-CEYAKTKLIKSEGRGYGLVAVEDIK---FIIEYCGEVISWKEAKR 579
C CG C N+ QK Y+ GRG+G+ ++ IK F++EY GEVI+ +EA+R
Sbjct: 229 CKCGPDCPNRVVQKGPPYSLCIFRTDNGRGWGVKTLQKIKKNSFVMEYVGEVITSEEAER 288
Query: 580 RAQTYETHG 606
R Q Y++ G
Sbjct: 289 RGQQYDSRG 297
>sp|Q32PH7|SUV92_BOVIN Histone-lysine N-methyltransferase SUV39H2 OS=Bos taurus
GN=SUV39H2 PE=2 SV=1
Length = 410
Score = 51 bits (120), Expect = 7e-006
Identities = 28/69 (40%), Positives = 41/69 (59%), Gaps = 4/69 (5%)
Frame = +1
Query: 412 CPCGVYCKNQKFQK-CEYAKTKLIKSEGRGYG---LVAVEDIKFIIEYCGEVISWKEAKR 579
C CG C N+ QK +Y+ S G G+G LV ++ + F++EY GEVI+ +EA+R
Sbjct: 233 CQCGPDCPNRIVQKGTQYSLCIFRTSNGCGWGVKTLVKIKRMSFVMEYVGEVITSEEAER 292
Query: 580 RAQTYETHG 606
R Q Y+ G
Sbjct: 293 RGQLYDNKG 301
>sp|Q9EQQ0|SUV92_MOUSE Histone-lysine N-methyltransferase SUV39H2 OS=Mus
musculus GN=Suv39h2 PE=1 SV=1
Length = 477
Score = 50 bits (119), Expect = 9e-006
Identities = 28/69 (40%), Positives = 41/69 (59%), Gaps = 4/69 (5%)
Frame = +1
Query: 412 CPCGVYCKNQKFQK-CEYAKTKLIKSEGRGYG---LVAVEDIKFIIEYCGEVISWKEAKR 579
C CG C N+ QK +Y+ S G G+G LV ++ + F++EY GEVI+ +EA+R
Sbjct: 300 CRCGPECPNRIVQKGTQYSLCIFKTSNGCGWGVKTLVKIKRMSFVMEYVGEVITSEEAER 359
Query: 580 RAQTYETHG 606
R Q Y+ G
Sbjct: 360 RGQFYDNKG 368
Database: UniProt/SwissProt
Posted date: Sat Aug 07 14:36:18 2010
Number of letters in database: 182,829,261
Number of sequences in database: 518,415
Lambda K H
0.267 0.041 0.140
Gapped
Lambda K H
0.267 0.041 0.140
Matrix: blosum62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 208,048,610,154
Number of Sequences: 518415
Number of Extensions: 208048610154
Number of Successful Extensions: 1281187403
Number of sequences better than 0.0: 0
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