BLASTX 7.6.2
Query= UN66160 /QuerySize=716
(715 letters)
Database: UniProt/SwissProt;
518,415 sequences; 182,829,261 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q0P570|ERG19_BOVIN Diphosphomevalonate decarboxylase OS=Bos t... 140 1e-032
sp|P53602|ERG19_HUMAN Diphosphomevalonate decarboxylase OS=Homo ... 138 5e-032
sp|Q99JF5|ERG19_MOUSE Diphosphomevalonate decarboxylase OS=Mus m... 136 2e-031
sp|Q5U403|ERG19_DANRE Diphosphomevalonate decarboxylase OS=Danio... 135 4e-031
sp|P32377|ERG19_YEAST Diphosphomevalonate decarboxylase OS=Sacch... 132 3e-030
sp|Q62967|ERG19_RAT Diphosphomevalonate decarboxylase OS=Rattus ... 131 8e-030
sp|Q6BY07|ERG19_DEBHA Diphosphomevalonate decarboxylase OS=Debar... 123 2e-027
sp|O13963|ERG19_SCHPO Diphosphomevalonate decarboxylase OS=Schiz... 118 5e-026
sp|Q751D8|ERG19_ASHGO Diphosphomevalonate decarboxylase OS=Ashby... 97 9e-020
sp|Q54YQ9|ERG19_DICDI Diphosphomevalonate decarboxylase OS=Dicty... 93 1e-018
>sp|Q0P570|ERG19_BOVIN Diphosphomevalonate decarboxylase OS=Bos taurus GN=MVD
PE=2 SV=1
Length = 400
Score = 140 bits (352), Expect = 1e-032
Identities = 78/154 (50%), Positives = 96/154 (62%), Gaps = 11/154 (7%)
Frame = +1
Query: 88 MAAEKWVHTVTAQTPTNIAVIKYWGKRDEVRILPVNDSISVTLDPDHLCTVTTVAVSPAF 267
MA+EK + VT P NIAV+KYWGKRDE ILP+N S+SVTL D L T TT A+S F
Sbjct: 1 MASEKPIVVVTCTAPVNIAVVKYWGKRDEELILPINSSLSVTLHQDQLKTTTTAAISRDF 60
Query: 268 DRDRMWLNGKEISLSGSRYQNCLREI----RSRGGDVEDKEKGVKIEKKDWERLNLHIAS 435
DR+WLNG+E + R Q CLREI R R D + + + K +H+AS
Sbjct: 61 TEDRIWLNGREEDMGHPRLQACLREIRRLARKRRSDGHEDPLPLSLSYK------VHVAS 114
Query: 436 HNNFPTAAGLASSAAGFACLGIYILVGLFFLSDD 537
NNFPTAAGLASSAAG+ACL Y L ++ + D
Sbjct: 115 ENNFPTAAGLASSAAGYACLA-YTLARVYGVDSD 147
>sp|P53602|ERG19_HUMAN Diphosphomevalonate decarboxylase OS=Homo sapiens GN=MVD
PE=1 SV=1
Length = 400
Score = 138 bits (346), Expect = 5e-032
Identities = 79/158 (50%), Positives = 94/158 (59%), Gaps = 19/158 (12%)
Frame = +1
Query: 88 MAAEKWVHTVTAQTPTNIAVIKYWGKRDEVRILPVNDSISVTLDPDHLCTVTTVAVSPAF 267
MA+EK + VT P NIAVIKYWGKRDE +LP+N S+SVTL D L T TT +S F
Sbjct: 1 MASEKPLAAVTCTAPVNIAVIKYWGKRDEELVLPINSSLSVTLHQDQLKTTTTAVISKDF 60
Query: 268 DRDRMWLNGKEISLSGSRYQNCLREIR--------SRGGDVEDKEKGVKIEKKDWERLNL 423
DR+WLNG+E + R Q CLREIR SR GD K+
Sbjct: 61 TEDRIWLNGREEDVGQPRLQACLREIRCLARKRRNSRDGDPLPSSLSCKV---------- 110
Query: 424 HIASHNNFPTAAGLASSAAGFACLGIYILVGLFFLSDD 537
H+AS NNFPTAAGLASSAAG+ACL Y L ++ + D
Sbjct: 111 HVASVNNFPTAAGLASSAAGYACLA-YTLARVYGVESD 147
>sp|Q99JF5|ERG19_MOUSE Diphosphomevalonate decarboxylase OS=Mus musculus GN=Mvd
PE=1 SV=2
Length = 401
Score = 136 bits (340), Expect = 2e-031
Identities = 75/141 (53%), Positives = 88/141 (62%), Gaps = 3/141 (2%)
Frame = +1
Query: 115 VTAQTPTNIAVIKYWGKRDEVRILPVNDSISVTLDPDHLCTVTTVAVSPAFDRDRMWLNG 294
VT P NIAVIKYWGKRDE ILP+N S+SVTL D L T TTVA+S F DR+WLNG
Sbjct: 11 VTCTAPVNIAVIKYWGKRDEALILPINSSLSVTLHQDQLKTTTTVAISKDFTEDRIWLNG 70
Query: 295 KEISLSGSRYQNCLREIRSRGGDVEDKEKGVKIEKKDWERLNLHIASHNNFPTAAGLASS 474
+E + R Q CLREIR E G + +H+AS NNFPTAAGLASS
Sbjct: 71 REEDVGQPRLQACLREIRRLARKRRSTEDGDTLPLS--LSYKVHVASVNNFPTAAGLASS 128
Query: 475 AAGFACLGIYILVGLFFLSDD 537
AAG+ACL Y L ++ + D
Sbjct: 129 AAGYACLA-YTLAQVYGVEGD 148
>sp|Q5U403|ERG19_DANRE Diphosphomevalonate decarboxylase OS=Danio rerio GN=mvd
PE=2 SV=1
Length = 400
Score = 135 bits (338), Expect = 4e-031
Identities = 77/136 (56%), Positives = 89/136 (65%), Gaps = 6/136 (4%)
Frame = +1
Query: 115 VTAQTPTNIAVIKYWGKRDEVRILPVNDSISVTLDPDHLCTVTTVAVSPAFDRDRMWLNG 294
VT P NIAVIKYWGKRDE ILPVN S+SVTL DHL T TT+A S +F +D +WLNG
Sbjct: 12 VTCTAPVNIAVIKYWGKRDEDLILPVNASLSVTLHQDHLRTTTTIACSRSFHKDCIWLNG 71
Query: 295 KEISLSGSRYQNCLREIRSRGGDVEDKEKGVKIEKKDWERLNLHIASHNNFPTAAGLASS 474
KE +S R Q+CL EIR + + K D +HI S NNFPTAAGLASS
Sbjct: 72 KEQDISHPRLQSCLLEIRR----LAQRRKNTGDPASDVSN-KVHICSVNNFPTAAGLASS 126
Query: 475 AAGFACLGIYILVGLF 522
AAG+ACL +Y L LF
Sbjct: 127 AAGYACL-VYTLSQLF 141
>sp|P32377|ERG19_YEAST Diphosphomevalonate decarboxylase OS=Saccharomyces
cerevisiae GN=ERG19 PE=1 SV=2
Length = 396
Score = 132 bits (331), Expect = 3e-030
Identities = 68/130 (52%), Positives = 85/130 (65%), Gaps = 4/130 (3%)
Frame = +1
Query: 106 VHTVTAQTPTNIAVIKYWGKRDEVRILPVNDSISVTLDPDHLCTVTTVAVSPAFDRDRMW 285
V+T + P NIA +KYWGKRD LP N SISVTL D L T+T+ A +P F+RD +W
Sbjct: 3 VYTASVTAPVNIATLKYWGKRDTKLNLPTNSSISVTLSQDDLRTLTSAATAPEFERDTLW 62
Query: 286 LNGKEISLSGSRYQNCLREIRSRGGDVEDKEKGVKIEKKDWERLNLHIASHNNFPTAAGL 465
LNG+ S+ R QNCLR++R ++E K+ + W+ LHI S NNFPTAAGL
Sbjct: 63 LNGEPHSIDNERTQNCLRDLRQLRKEMESKDASLP-TLSQWK---LHIVSENNFPTAAGL 118
Query: 466 ASSAAGFACL 495
ASSAAGFA L
Sbjct: 119 ASSAAGFAAL 128
>sp|Q62967|ERG19_RAT Diphosphomevalonate decarboxylase OS=Rattus norvegicus
GN=Mvd PE=2 SV=1
Length = 401
Score = 131 bits (327), Expect = 8e-030
Identities = 73/141 (51%), Positives = 86/141 (60%), Gaps = 3/141 (2%)
Frame = +1
Query: 115 VTAQTPTNIAVIKYWGKRDEVRILPVNDSISVTLDPDHLCTVTTVAVSPAFDRDRMWLNG 294
VT P NIAVIKYWGKRDE ILP+N S+SVTL D L T TT A+S F DR+WLNG
Sbjct: 11 VTCTAPVNIAVIKYWGKRDEALILPINPSLSVTLHQDQLKTTTTAAISKDFTEDRIWLNG 70
Query: 295 KEISLSGSRYQNCLREIRSRGGDVEDKEKGVKIEKKDWERLNLHIASHNNFPTAAGLASS 474
+E + R Q CLREIR G + +H+AS NNFPTAAGLASS
Sbjct: 71 REEDVGQPRLQACLREIRRLARKRRSTGDGDALPLS--LGYKVHVASVNNFPTAAGLASS 128
Query: 475 AAGFACLGIYILVGLFFLSDD 537
AAG+ACL Y L ++ + D
Sbjct: 129 AAGYACLA-YTLARVYGVEGD 148
>sp|Q6BY07|ERG19_DEBHA Diphosphomevalonate decarboxylase OS=Debaryomyces
hansenii GN=ERG19 PE=3 SV=2
Length = 388
Score = 123 bits (307), Expect = 2e-027
Identities = 65/134 (48%), Positives = 85/134 (63%), Gaps = 4/134 (2%)
Frame = +1
Query: 106 VHTVTAQTPTNIAVIKYWGKRDEVRILPVNDSISVTLDPDHLCTVTTVAVSPAFDRDRMW 285
V+T +A P NIA +KYWGKRD+ LP N SISVTL + L T+T+VA S F D++W
Sbjct: 3 VYTSSATAPVNIATLKYWGKRDKSLNLPTNSSISVTLSQNDLRTLTSVAASEDFKEDKLW 62
Query: 286 LNGKEISLSGSRYQNCLREIRSRGGDVEDKEKGVKIEKKDWERLNLHIASHNNFPTAAGL 465
LNGK SL R + CL ++R+ ++E + + + +HI S NNFPTAAGL
Sbjct: 63 LNGKLESLESERTKACLADLRTLRKELESNDSSI----PKLSQFGVHIVSENNFPTAAGL 118
Query: 466 ASSAAGFACLGIYI 507
ASSAAGFA L + I
Sbjct: 119 ASSAAGFAALVVSI 132
>sp|O13963|ERG19_SCHPO Diphosphomevalonate decarboxylase OS=Schizosaccharomyces
pombe GN=erg19 PE=2 SV=1
Length = 393
Score = 118 bits (294), Expect = 5e-026
Identities = 67/135 (49%), Positives = 82/135 (60%), Gaps = 11/135 (8%)
Frame = +1
Query: 97 EKWVHTVTAQTPTNIAVIKYWGKRDEVRILPVNDSISVTLDPDHLCTVTTVAVSPAFDRD 276
+K V+ T P NIAVIKYWGKRD LP N SISVTL D L TVTT + S F+ D
Sbjct: 2 DKKVYQCTVSAPVNIAVIKYWGKRDVALNLPTNSSISVTLSQDDLRTVTTASCSEKFEND 61
Query: 277 RMWLNGK-EISLSGSRYQNCLREIRSRGGDVEDKEKGVKIEKKDWER---LNLHIASHNN 444
+WLNG E + R + C+ E+R D+E+ E D ++ L LH+ S NN
Sbjct: 62 TLWLNGNAEEIFANKRLRVCVEELRKARLDLEE-------ENDDLDKIGALKLHVVSENN 114
Query: 445 FPTAAGLASSAAGFA 489
FPTAAGLASSAAG+A
Sbjct: 115 FPTAAGLASSAAGYA 129
>sp|Q751D8|ERG19_ASHGO Diphosphomevalonate decarboxylase OS=Ashbya gossypii
GN=ERG19 PE=3 SV=1
Length = 372
Score = 97 bits (240), Expect = 9e-020
Identities = 53/108 (49%), Positives = 68/108 (62%), Gaps = 4/108 (3%)
Frame = +1
Query: 184 LPVNDSISVTLDPDHLCTVTTVAVSPAFDRDRMWLNGKEISLSGSRYQNCLREIRSRGGD 363
LP N SISVTL + L T+T+ A P DR+WLNGK SL +R Q CL ++R+
Sbjct: 4 LPTNSSISVTLSQEDLRTLTSAATGPELAEDRLWLNGKPESLGNARTQQCLADLRALRRA 63
Query: 364 VEDKEKGVKIEKKDWERLNLHIASHNNFPTAAGLASSAAGFACLGIYI 507
+E +E + +W+ LHI S NNFPTAAGLASSAAGFA L + +
Sbjct: 64 LETEEPDLP-RMSEWK---LHIVSENNFPTAAGLASSAAGFAALVVAV 107
>sp|Q54YQ9|ERG19_DICDI Diphosphomevalonate decarboxylase OS=Dictyostelium
discoideum GN=mvd PE=3 SV=1
Length = 391
Score = 93 bits (230), Expect = 1e-018
Identities = 48/94 (51%), Positives = 61/94 (64%)
Frame = +1
Query: 112 TVTAQTPTNIAVIKYWGKRDEVRILPVNDSISVTLDPDHLCTVTTVAVSPAFDRDRMWLN 291
+VT P NIAVIKYWGKRDE ILP+N S+S TL D L T TT+ S + D ++LN
Sbjct: 5 SVTCTAPVNIAVIKYWGKRDENIILPLNSSLSGTLHQDDLKTTTTIVASEDYTEDELYLN 64
Query: 292 GKEISLSGSRYQNCLREIRSRGGDVEDKEKGVKI 393
GK+ ++ RYQN L+ IRSR + DK+ V I
Sbjct: 65 GKKEDINAVRYQNVLKMIRSRATKLMDKKHCVHI 98
Database: UniProt/SwissProt
Posted date: Sat Aug 07 14:36:18 2010
Number of letters in database: 182,829,261
Number of sequences in database: 518,415
Lambda K H
0.267 0.041 0.140
Gapped
Lambda K H
0.267 0.041 0.140
Matrix: blosum62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 224,586,243,839
Number of Sequences: 518415
Number of Extensions: 224586243839
Number of Successful Extensions: 1413644693
Number of sequences better than 0.0: 0
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