BLASTX 7.6.2
Query= UN69281 /QuerySize=635
(634 letters)
Database: UniProt/SwissProt;
518,415 sequences; 182,829,261 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P42744|ULA1_ARATH NEDD8-activating enzyme E1 regulatory subun... 329 1e-089
sp|Q8VBW6|ULA1_MOUSE NEDD8-activating enzyme E1 regulatory subun... 206 1e-052
sp|Q9Z1A5|ULA1_RAT NEDD8-activating enzyme E1 regulatory subunit... 206 1e-052
sp|Q6NTW6|ULA1_XENLA NEDD8-activating enzyme E1 regulatory subun... 204 4e-052
sp|Q5ZIE6|ULA1_CHICK NEDD8-activating enzyme E1 regulatory subun... 203 1e-051
sp|Q13564|ULA1_HUMAN NEDD8-activating enzyme E1 regulatory subun... 203 1e-051
sp|Q7SXP2|ULA1_DANRE NEDD8-activating enzyme E1 regulatory subun... 196 2e-049
sp|Q54JM3|ULA1_DICDI NEDD8-activating enzyme E1 regulatory subun... 184 5e-046
sp|Q9VTE9|ULA1_DROME NEDD8-activating enzyme E1 regulatory subun... 167 6e-041
sp|Q9UT93|ULA1_SCHPO NEDD8-activating enzyme E1 regulatory subun... 145 2e-034
sp|Q18217|ULA1_CAEEL NEDD8-activating enzyme E1 regulatory subun... 132 3e-030
sp|Q06624|RHC31_YEAST DNA damage tolerance protein RHC31 OS=Sacc... 116 1e-025
sp|Q28DS0|SAE1_XENTR SUMO-activating enzyme subunit 1 OS=Xenopus... 99 3e-020
sp|Q4R3L6|ULA1_MACFA NEDD8-activating enzyme E1 regulatory subun... 98 3e-020
sp|Q8JGT5|SAE1_XENLA SUMO-activating enzyme subunit 1 OS=Xenopus... 98 4e-020
sp|A2VE14|SAE1_BOVIN SUMO-activating enzyme subunit 1 OS=Bos tau... 96 2e-019
sp|Q9UBE0|SAE1_HUMAN SUMO-activating enzyme subunit 1 OS=Homo sa... 95 4e-019
sp|Q5NVN7|SAE1_PONAB SUMO-activating enzyme subunit 1 OS=Pongo a... 95 4e-019
sp|Q6AXQ0|SAE1_RAT SUMO-activating enzyme subunit 1 OS=Rattus no... 92 2e-018
>sp|P42744|ULA1_ARATH NEDD8-activating enzyme E1 regulatory subunit
OS=Arabidopsis thaliana GN=AXR1 PE=1 SV=1
Length = 540
Score = 329 bits (842), Expect = 1e-089
Identities = 162/193 (83%), Positives = 176/193 (91%), Gaps = 1/193 (0%)
Frame = +3
Query: 54 EQEATMSEPTKTKYDRQLRIWGEVGQAALENASICLLNCGPTGSEALKNLVLGGIGSITV 233
E+E TM EP KTKYDRQLRIWGEVGQAALE ASICLLNCGPTGSEALKNLVLGG+GSITV
Sbjct: 12 EEEPTMVEP-KTKYDRQLRIWGEVGQAALEEASICLLNCGPTGSEALKNLVLGGVGSITV 70
Query: 234 VDGSKVEIGDLGNNFMLDKNSVGESKAKTVCAFLQELNDAVKANFVEDNPDSLILSDPSF 413
VDGSKV+ GDLGNNFM+D SVG+SKAK+VCAFLQELND+V A F+E+NPD+LI ++PSF
Sbjct: 71 VDGSKVQFGDLGNNFMVDAKSVGQSKAKSVCAFLQELNDSVNAKFIEENPDTLITTNPSF 130
Query: 414 FSQFTLVIATQLVEDSMVKLDRICREANVMLVFARSYGLTGLVRISVKEHTIIDSKPDHF 593
FSQFTLVIATQLVEDSM+KLDRICR+ANV LV RSYGL G VRISVKEH IIDSKPDHF
Sbjct: 131 FSQFTLVIATQLVEDSMLKLDRICRDANVKLVLVRSYGLAGFVRISVKEHPIIDSKPDHF 190
Query: 594 LDDLRLNTPWPEL 632
LDDLRLN PWPEL
Sbjct: 191 LDDLRLNNPWPEL 203
>sp|Q8VBW6|ULA1_MOUSE NEDD8-activating enzyme E1 regulatory subunit OS=Mus
musculus GN=Nae1 PE=2 SV=1
Length = 534
Score = 206 bits (523), Expect = 1e-052
Identities = 98/192 (51%), Positives = 143/192 (74%), Gaps = 4/192 (2%)
Frame = +3
Query: 69 MSEPTK----TKYDRQLRIWGEVGQAALENASICLLNCGPTGSEALKNLVLGGIGSITVV 236
M++P K KYDRQLR+WG+ GQ ALE+A +CL+N TG+E LKNLVL GIGS T++
Sbjct: 1 MAQPGKILKEQKYDRQLRLWGDHGQEALESAHVCLINATATGTEILKNLVLPGIGSFTII 60
Query: 237 DGSKVEIGDLGNNFMLDKNSVGESKAKTVCAFLQELNDAVKANFVEDNPDSLILSDPSFF 416
DG+ V D GNNF L K+S+G+++A+ FLQELN V +FVE++P++L+ +DPSFF
Sbjct: 61 DGNLVSGEDAGNNFFLQKSSIGKNRAQAAMEFLQELNSDVSGSFVEESPENLLDNDPSFF 120
Query: 417 SQFTLVIATQLVEDSMVKLDRICREANVMLVFARSYGLTGLVRISVKEHTIIDSKPDHFL 596
+FT+V+ATQL+E ++++L + + + L+ R+YGL G +RI +KEH +I+S PD+ L
Sbjct: 121 CRFTIVVATQLLESTLLRLADVLWNSQIPLLICRTYGLVGYMRIIIKEHPVIESHPDNAL 180
Query: 597 DDLRLNTPWPEL 632
+DLRL+ P+PEL
Sbjct: 181 EDLRLDKPFPEL 192
>sp|Q9Z1A5|ULA1_RAT NEDD8-activating enzyme E1 regulatory subunit OS=Rattus
norvegicus GN=Nae1 PE=1 SV=1
Length = 534
Score = 206 bits (522), Expect = 1e-052
Identities = 95/181 (52%), Positives = 139/181 (76%)
Frame = +3
Query: 90 KYDRQLRIWGEVGQAALENASICLLNCGPTGSEALKNLVLGGIGSITVVDGSKVEIGDLG 269
KYDRQLR+WG+ GQ ALE+A +CL+N TG+E LKNLVL GIGS T++DG++V D+G
Sbjct: 12 KYDRQLRLWGDHGQEALESAHVCLINATATGTEILKNLVLPGIGSFTIIDGNQVSGEDVG 71
Query: 270 NNFMLDKNSVGESKAKTVCAFLQELNDAVKANFVEDNPDSLILSDPSFFSQFTLVIATQL 449
NNF L K S+G+++A+ FLQELN V +FVE++P++L+ +DPSFF +FT+V+ATQL
Sbjct: 72 NNFFLQKCSIGKNRAQAAMEFLQELNSDVSGSFVEESPENLLDNDPSFFCRFTIVVATQL 131
Query: 450 VEDSMVKLDRICREANVMLVFARSYGLTGLVRISVKEHTIIDSKPDHFLDDLRLNTPWPE 629
+E ++++L + + + L+ R+YGL G +RI +KEH +I+S PD+ L+DLRL+ P+PE
Sbjct: 132 LESTLLRLADVLWNSQIPLLICRTYGLVGYMRIIIKEHPVIESHPDNALEDLRLDKPFPE 191
Query: 630 L 632
L
Sbjct: 192 L 192
>sp|Q6NTW6|ULA1_XENLA NEDD8-activating enzyme E1 regulatory subunit OS=Xenopus
laevis GN=nae1 PE=2 SV=1
Length = 533
Score = 204 bits (518), Expect = 4e-052
Identities = 98/181 (54%), Positives = 135/181 (74%)
Frame = +3
Query: 90 KYDRQLRIWGEVGQAALENASICLLNCGPTGSEALKNLVLGGIGSITVVDGSKVEIGDLG 269
KYDRQLR+WG+ GQ ALE+A +CL+N TG+E LKNLVL GIG T+VDG+ V D+G
Sbjct: 11 KYDRQLRLWGDHGQEALESAHVCLINATATGTEILKNLVLPGIGLFTIVDGNVVAGEDVG 70
Query: 270 NNFMLDKNSVGESKAKTVCAFLQELNDAVKANFVEDNPDSLILSDPSFFSQFTLVIATQL 449
NNF L K S+G+++A+T LQELND V NFV ++P+ L+ DPSFF +FT+VI+TQL
Sbjct: 71 NNFFLQKESIGKNRAQTSMELLQELNDDVTGNFVPESPEQLLDKDPSFFCKFTMVISTQL 130
Query: 450 VEDSMVKLDRICREANVMLVFARSYGLTGLVRISVKEHTIIDSKPDHFLDDLRLNTPWPE 629
E ++++L ++N+ L+ R+YG G +RI VKEHT+I+S PD+ L+DLRL+ P+PE
Sbjct: 131 PESTLLRLAETLWDSNIPLLVCRAYGFVGYMRIIVKEHTVIESHPDNALEDLRLDQPFPE 190
Query: 630 L 632
L
Sbjct: 191 L 191
>sp|Q5ZIE6|ULA1_CHICK NEDD8-activating enzyme E1 regulatory subunit OS=Gallus
gallus GN=NAE1 PE=2 SV=1
Length = 535
Score = 203 bits (515), Expect = 1e-051
Identities = 93/181 (51%), Positives = 139/181 (76%)
Frame = +3
Query: 90 KYDRQLRIWGEVGQAALENASICLLNCGPTGSEALKNLVLGGIGSITVVDGSKVEIGDLG 269
+YDRQLR+WG+ GQ ALE+A +C++N TG+E LKNLVL GIGS T+VDG++V D+G
Sbjct: 13 RYDRQLRLWGDHGQEALESAHVCVINATATGTEILKNLVLPGIGSFTIVDGNRVSGEDVG 72
Query: 270 NNFMLDKNSVGESKAKTVCAFLQELNDAVKANFVEDNPDSLILSDPSFFSQFTLVIATQL 449
NNF L K+ +G+S+A++ LQELN+ V NFVE++P++L+ +DPSFF++F LV+ATQL
Sbjct: 73 NNFFLQKSHIGQSRAQSATELLQELNNDVSGNFVEESPETLLDNDPSFFNRFNLVVATQL 132
Query: 450 VEDSMVKLDRICREANVMLVFARSYGLTGLVRISVKEHTIIDSKPDHFLDDLRLNTPWPE 629
E ++++L + +N+ L+ R+YGL G +RI +KEH +++S PD+ L+DLRL+ +PE
Sbjct: 133 SESTVLRLAELLWNSNIPLLICRTYGLVGYMRIIIKEHPVVESHPDNALEDLRLDKQFPE 192
Query: 630 L 632
L
Sbjct: 193 L 193
>sp|Q13564|ULA1_HUMAN NEDD8-activating enzyme E1 regulatory subunit OS=Homo
sapiens GN=NAE1 PE=1 SV=1
Length = 534
Score = 203 bits (514), Expect = 1e-051
Identities = 94/181 (51%), Positives = 137/181 (75%)
Frame = +3
Query: 90 KYDRQLRIWGEVGQAALENASICLLNCGPTGSEALKNLVLGGIGSITVVDGSKVEIGDLG 269
KYDRQLR+WG+ GQ ALE+A +CL+N TG+E LKNLVL GIGS T++DG++V D G
Sbjct: 12 KYDRQLRLWGDHGQEALESAHVCLINATATGTEILKNLVLPGIGSFTIIDGNQVSGEDAG 71
Query: 270 NNFMLDKNSVGESKAKTVCAFLQELNDAVKANFVEDNPDSLILSDPSFFSQFTLVIATQL 449
NNF L ++S+G+++A+ FLQELN V +FVE++P++L+ +DPSFF +FT+V+ATQL
Sbjct: 72 NNFFLQRSSIGKNRAEAAMEFLQELNSDVSGSFVEESPENLLDNDPSFFCRFTVVVATQL 131
Query: 450 VEDSMVKLDRICREANVMLVFARSYGLTGLVRISVKEHTIIDSKPDHFLDDLRLNTPWPE 629
E + ++L + + + L+ R+YGL G +RI +KEH +I+S PD+ L+DLRL+ P+PE
Sbjct: 132 PESTSLRLADVLWNSQIPLLICRTYGLVGYMRIIIKEHPVIESHPDNALEDLRLDKPFPE 191
Query: 630 L 632
L
Sbjct: 192 L 192
>sp|Q7SXP2|ULA1_DANRE NEDD8-activating enzyme E1 regulatory subunit OS=Danio
rerio GN=nae1 PE=2 SV=2
Length = 533
Score = 196 bits (496), Expect = 2e-049
Identities = 94/181 (51%), Positives = 131/181 (72%)
Frame = +3
Query: 90 KYDRQLRIWGEVGQAALENASICLLNCGPTGSEALKNLVLGGIGSITVVDGSKVEIGDLG 269
KYDRQLR+WG+ GQ ALENA +CL+N +G+E LKNLVL GIG+ T+VDG KV D+G
Sbjct: 11 KYDRQLRLWGDHGQEALENAHVCLINATASGTEILKNLVLPGIGAFTIVDGHKVSGEDVG 70
Query: 270 NNFMLDKNSVGESKAKTVCAFLQELNDAVKANFVEDNPDSLILSDPSFFSQFTLVIATQL 449
NNF L +++G+++A+ LQELN V NFVE++PD L+ +D FF +F+LVIA QL
Sbjct: 71 NNFFLSSSAIGKNRAQAATELLQELNSDVSGNFVEESPDKLLDNDCEFFHRFSLVIAVQL 130
Query: 450 VEDSMVKLDRICREANVMLVFARSYGLTGLVRISVKEHTIIDSKPDHFLDDLRLNTPWPE 629
E + ++L + EA V + R+YGL G +R+ VKEHT+++S PD+ L+DLRL+ P+ E
Sbjct: 131 PESTCLRLGAVLWEAGVPFLVCRTYGLIGYMRLIVKEHTVVESHPDNALEDLRLDQPFTE 190
Query: 630 L 632
L
Sbjct: 191 L 191
>sp|Q54JM3|ULA1_DICDI NEDD8-activating enzyme E1 regulatory subunit
OS=Dictyostelium discoideum GN=nae1 PE=3 SV=1
Length = 520
Score = 184 bits (466), Expect = 5e-046
Identities = 94/181 (51%), Positives = 125/181 (69%)
Frame = +3
Query: 90 KYDRQLRIWGEVGQAALENASICLLNCGPTGSEALKNLVLGGIGSITVVDGSKVEIGDLG 269
KYDRQLR+WGE GQ+ LE + I LLN TG+E LKNLVL GIGS TVVD KV DLG
Sbjct: 10 KYDRQLRLWGEDGQSKLERSHILLLNGSATGTETLKNLVLPGIGSFTVVDNKKVTESDLG 69
Query: 270 NNFMLDKNSVGESKAKTVCAFLQELNDAVKANFVEDNPDSLILSDPSFFSQFTLVIATQL 449
NNF ++++S+G+ +A VC L+ELND VK VE+ P LI ++ SFF F+LV+A +L
Sbjct: 70 NNFFVERSSLGKPRATVVCELLRELNDRVKGFSVEECPIHLINNNISFFKDFSLVVANRL 129
Query: 450 VEDSMVKLDRICREANVMLVFARSYGLTGLVRISVKEHTIIDSKPDHFLDDLRLNTPWPE 629
E++++ L + E N+ L+ SYG G +RIS EH II+SKPD +DDLR+ P+ +
Sbjct: 130 SEEALLTLSQYLTEQNIPLLITNSYGYIGYLRISTPEHQIIESKPDDPIDDLRIYNPFKQ 189
Query: 630 L 632
L
Sbjct: 190 L 190
>sp|Q9VTE9|ULA1_DROME NEDD8-activating enzyme E1 regulatory subunit
OS=Drosophila melanogaster GN=APP-BP1 PE=1 SV=1
Length = 524
Score = 167 bits (422), Expect = 6e-041
Identities = 86/188 (45%), Positives = 122/188 (64%), Gaps = 1/188 (0%)
Frame = +3
Query: 69 MSEPTKTKYDRQLRIWGEVGQAALENASICLLNCGPTGSEALKNLVLGGIGSITVVDGSK 248
+S+ +K KYDRQ+R+WGE GQ LE A++CL+N G E K LVL GIG TV DGS
Sbjct: 11 LSDKSK-KYDRQIRLWGEHGQTLLEAATVCLVNVTAVGCETAKGLVLPGIGGFTVADGST 69
Query: 249 VEIGDLGNNFMLDKNSVGESKAKTVCAFLQELNDAVKANFVEDNPDSLILSDPSFFSQFT 428
V+ DLGNNF LD + +G+SKA LQELN V ++V+++ D L+ + P+FF F
Sbjct: 70 VKEEDLGNNFFLDSSYLGKSKALACMQLLQELNPDVNGDYVDESADFLLANRPNFFDSFD 129
Query: 429 LVIATQLVEDSMVKLDRICREANVMLVFARSYGLTGLVRISVKEHTIIDSKPDHFLDDLR 608
LVIA+ L E +++ L E NV L++ RS G+ G +R+ ++EH I+++ PD+ DLR
Sbjct: 130 LVIASNLNEQTLLLLAERLWELNVPLIYCRSLGMLGTIRLQIREHCIVEAHPDNRQFDLR 189
Query: 609 LNTPWPEL 632
L P+ L
Sbjct: 190 LEHPFDAL 197
>sp|Q9UT93|ULA1_SCHPO NEDD8-activating enzyme E1 regulatory subunit
OS=Schizosaccharomyces pombe GN=ula1 PE=2 SV=1
Length = 500
Score = 145 bits (365), Expect = 2e-034
Identities = 73/181 (40%), Positives = 112/181 (61%), Gaps = 1/181 (0%)
Frame = +3
Query: 90 KYDRQLRIWGEVGQAALENASICLLNCGPTGSEALKNLVLGGIGSITVVDGSKVEIGDLG 269
KYDRQ+R+W GQ A+E + +CLL G EALKNL+L GIGS VVD + V+ G
Sbjct: 9 KYDRQVRLWKAEGQNAIEKSHVCLLYANTVGCEALKNLILPGIGSFAVVDDTSVDFSMDG 68
Query: 270 NNFMLDKNSVGESKAKTVCAFLQELNDAVKANFVEDNPDSLILSDPSFFSQFTLVIATQL 449
NF + + G+S+A+ + LQ+LN V+ ++E +P++LI + +FS+F++V+++ L
Sbjct: 69 MNFFIQYDQEGKSRARCTASLLQQLNPNVEMEYLEMSPEALIDKNIEYFSKFSVVLSSNL 128
Query: 450 VEDSMVKLDRICREANVMLVFARSYGLTGLVRISVKEHTIIDSKPDHFLDDLRLNTPWPE 629
E + +L+ R + L+ S G G++RIS E+T S+P+ DLRL PWPE
Sbjct: 129 KEKPLFRLEEYLRSHKIPLLHFNSVGFAGILRISTHEYTTTQSQPE-LPQDLRLKNPWPE 187
Query: 630 L 632
L
Sbjct: 188 L 188
>sp|Q18217|ULA1_CAEEL NEDD8-activating enzyme E1 regulatory subunit
OS=Caenorhabditis elegans GN=ula-1 PE=2 SV=2
Length = 541
Score = 132 bits (330), Expect = 3e-030
Identities = 67/182 (36%), Positives = 106/182 (58%)
Frame = +3
Query: 87 TKYDRQLRIWGEVGQAALENASICLLNCGPTGSEALKNLVLGGIGSITVVDGSKVEIGDL 266
T+YDRQ+R+WGE GQA++ + S C+L +E LK+LVL G+ S VVD +KVE D+
Sbjct: 8 TRYDRQVRLWGEEGQASIGSTSACVLGSDSLATEILKSLVLAGVQSFYVVDDAKVEQADI 67
Query: 267 GNNFMLDKNSVGESKAKTVCAFLQELNDAVKANFVEDNPDSLILSDPSFFSQFTLVIATQ 446
G NF L + +G S+A+ L ELN +V + P +L + D + F++V+A
Sbjct: 68 GQNFFLHADDIGRSRAEATLEKLTELNPSVSGSASSQPPTALAMEDVEKLTTFSVVVAAN 127
Query: 447 LVEDSMVKLDRICREANVMLVFARSYGLTGLVRISVKEHTIIDSKPDHFLDDLRLNTPWP 626
E+ ++ V + +++GL G +RI +KEHTI +S ++ DLRL+ P+
Sbjct: 128 QNEEIDTTFAKVLYNIRVPFICIKTFGLIGTIRICIKEHTIANSHEENPRPDLRLDAPFS 187
Query: 627 EL 632
+L
Sbjct: 188 KL 189
>sp|Q06624|RHC31_YEAST DNA damage tolerance protein RHC31 OS=Saccharomyces
cerevisiae GN=AOS1 PE=1 SV=1
Length = 347
Score = 116 bits (290), Expect = 1e-025
Identities = 65/177 (36%), Positives = 96/177 (54%), Gaps = 3/177 (1%)
Frame = +3
Query: 51 DEQEATMSEPTKTKYDRQLRIWGEVGQAALENASICLLNCGPTGSEALKNLVLGGIGSIT 230
D + +SE YDRQ+R+WG QA + +A + L+N G GSE K++VL GIG +T
Sbjct: 2 DMKVEKLSEDEIALYDRQIRLWGMTAQANMRSAKVLLINLGAIGSEITKSIVLSGIGHLT 61
Query: 231 VVDGSKVEIGDLGNNFMLDKNSVGESKAKTVCAFLQELNDAVKANFVEDNPDSLILSDPS 410
++DG V DLG+ F + VG+ K +Q+LN ++ NF + L D
Sbjct: 62 ILDGHMVTEEDLGSQFFIGSEDVGQWKIDATKERIQDLNPRIELNF---DKQDLQEKDEE 118
Query: 411 FFSQFTLVIATQLVEDSMVKLDRICREANVMLVFARSYGLTGLVRISVKEHTIIDSK 581
FF QF LV+AT++ D +K++ + R+ N+ L A S GL V I + E D K
Sbjct: 119 FFQQFDLVVATEMQIDEAIKINTLTRKLNIPLYVAGSNGLFAYVFIDLIEFISEDEK 175
>sp|Q28DS0|SAE1_XENTR SUMO-activating enzyme subunit 1 OS=Xenopus tropicalis
GN=sae1 PE=2 SV=1
Length = 347
Score = 99 bits (244), Expect = 3e-020
Identities = 51/177 (28%), Positives = 93/177 (52%), Gaps = 3/177 (1%)
Frame = +3
Query: 51 DEQEATMSEPTKTKYDRQLRIWGEVGQAALENASICLLNCGPTGSEALKNLVLGGIGSIT 230
+++EA +SE +YDRQ+R+WG Q L + + L+ G+E KNL+L G+ ++T
Sbjct: 3 EKEEAVISEEEAAQYDRQIRLWGLEAQKRLRTSRVLLVGMRGLGAEVAKNLILAGVKALT 62
Query: 231 VVDGSKVEIGDLGNNFMLDKNSVGESKAKTVCAFLQELNDAVKANFVEDNPDSLILSDPS 410
++D +V D F++ S+G+++A+ + LN V VE + +++
Sbjct: 63 LLDHEQVSSEDSRAQFLIPSGSLGQNRAEASLNRARNLNPMVS---VEADTENINQKSDD 119
Query: 411 FFSQFTLVIATQLVEDSMVKLDRICREANVMLVFARSYGLTGLVRISVKEHTIIDSK 581
FF+QF +V T D +V++D IC + N+ +G G + + EH ++ K
Sbjct: 120 FFTQFDVVCLTSCSRDLLVRVDHICHKHNIKFFTGDVFGYHGYMFADLGEHEFVEEK 176
>sp|Q4R3L6|ULA1_MACFA NEDD8-activating enzyme E1 regulatory subunit OS=Macaca
fascicularis GN=NAE1 PE=2 SV=1
Length = 510
Score = 98 bits (243), Expect = 3e-020
Identities = 47/84 (55%), Positives = 63/84 (75%), Gaps = 4/84 (4%)
Frame = +3
Query: 69 MSEPTK----TKYDRQLRIWGEVGQAALENASICLLNCGPTGSEALKNLVLGGIGSITVV 236
M++P K KYDRQLR+WG+ GQ ALE+A +CL+N TG+E LKNLVL GIGS T++
Sbjct: 1 MAQPGKLLKEQKYDRQLRLWGDHGQEALESAHVCLINATATGTEILKNLVLPGIGSFTII 60
Query: 237 DGSKVEIGDLGNNFMLDKNSVGES 308
DG++V D GNNF L ++S+G+S
Sbjct: 61 DGNQVSGEDAGNNFFLQRSSIGKS 84
Score = 92 bits (226), Expect = 3e-018
Identities = 46/123 (37%), Positives = 79/123 (64%), Gaps = 8/123 (6%)
Frame = +3
Query: 264 LGNNFMLDKNSVGESKAKTVCAFLQELNDAVKANFVEDNPDSLILSDPSFFSQFTLVIAT 443
+G+ ++D N V A N ++ + + +P++L+ +DPSFF +FT+V+AT
Sbjct: 54 IGSFTIIDGNQVSGEDAGN--------NFFLQRSSIGKSPENLLDNDPSFFCRFTVVVAT 105
Query: 444 QLVEDSMVKLDRICREANVMLVFARSYGLTGLVRISVKEHTIIDSKPDHFLDDLRLNTPW 623
QL E ++++L + + + L+ R+YGL G +RI +KEH +I+S PD+ L+DLRL+ P+
Sbjct: 106 QLPESTLLRLADVLWNSQIPLLICRTYGLVGYMRIIIKEHPVIESHPDNALEDLRLDKPF 165
Query: 624 PEL 632
PEL
Sbjct: 166 PEL 168
>sp|Q8JGT5|SAE1_XENLA SUMO-activating enzyme subunit 1 OS=Xenopus laevis GN=sae1
PE=2 SV=1
Length = 344
Score = 98 bits (242), Expect = 4e-020
Identities = 51/177 (28%), Positives = 93/177 (52%), Gaps = 3/177 (1%)
Frame = +3
Query: 51 DEQEATMSEPTKTKYDRQLRIWGEVGQAALENASICLLNCGPTGSEALKNLVLGGIGSIT 230
+++EA +SE +YDRQ+R+WG Q L + + L+ G+E KNL+L G+ ++T
Sbjct: 3 EKEEAVISEEEAAQYDRQIRLWGLEAQKRLRTSRVLLVGMRGLGAEVAKNLILAGVKALT 62
Query: 231 VVDGSKVEIGDLGNNFMLDKNSVGESKAKTVCAFLQELNDAVKANFVEDNPDSLILSDPS 410
++D +V D F++ S+G+++A+ + LN V VE + +++
Sbjct: 63 LLDHEQVSSEDSRAQFLIPSGSLGQNRAEASLNRARNLNPMVS---VEADTENINQKSDD 119
Query: 411 FFSQFTLVIATQLVEDSMVKLDRICREANVMLVFARSYGLTGLVRISVKEHTIIDSK 581
FF+QF +V T D +V+++ IC + N+ YG G + + EH ++ K
Sbjct: 120 FFTQFDVVCLTSCPSDLLVRVNHICHKHNIKFFTGDVYGYHGSMFADLGEHEFVEEK 176
>sp|A2VE14|SAE1_BOVIN SUMO-activating enzyme subunit 1 OS=Bos taurus GN=SAE1
PE=2 SV=1
Length = 346
Score = 96 bits (237), Expect = 2e-019
Identities = 54/180 (30%), Positives = 93/180 (51%), Gaps = 3/180 (1%)
Frame = +3
Query: 42 MERDEQEATMSEPTKTKYDRQLRIWGEVGQAALENASICLLNCGPTGSEALKNLVLGGIG 221
+E++E +SE +YDRQ+R+WG Q L + + L+ G+E KNL+L G+
Sbjct: 2 VEKEEAGGGISEEEAAQYDRQIRLWGLEAQKRLRASQVLLVGMKGLGAEIAKNLILAGVK 61
Query: 222 SITVVDGSKVEIGDLGNNFMLDKNSVGESKAKTVCAFLQELNDAVKANFVEDNPDSLILS 401
+T++D +V D G F++ SVG ++A+ Q LN V V+ + +++
Sbjct: 62 GLTMLDHEQVSPEDPGAQFLIRTGSVGRNRAEASLERAQNLNPMVD---VKVDTENIEKK 118
Query: 402 DPSFFSQFTLVIATQLVEDSMVKLDRICREANVMLVFARSYGLTGLVRISVKEHTIIDSK 581
SFF+QF V T D +VK+D+IC + ++ +G G ++ EH ++ K
Sbjct: 119 PESFFTQFDAVCLTCCSRDVIVKVDQICHKNSIKFFTGDVFGYHGYTFANLGEHEFVEEK 178
>sp|Q9UBE0|SAE1_HUMAN SUMO-activating enzyme subunit 1 OS=Homo sapiens GN=SAE1
PE=1 SV=1
Length = 346
Score = 95 bits (234), Expect = 4e-019
Identities = 54/180 (30%), Positives = 92/180 (51%), Gaps = 3/180 (1%)
Frame = +3
Query: 42 MERDEQEATMSEPTKTKYDRQLRIWGEVGQAALENASICLLNCGPTGSEALKNLVLGGIG 221
+E++E +SE +YDRQ+R+WG Q L + + L+ G+E KNL+L G+
Sbjct: 2 VEKEEAGGGISEEEAAQYDRQIRLWGLEAQKRLRASRVLLVGLKGLGAEIAKNLILAGVK 61
Query: 222 SITVVDGSKVEIGDLGNNFMLDKNSVGESKAKTVCAFLQELNDAVKANFVEDNPDSLILS 401
+T++D +V D G F++ SVG ++A+ Q LN V V+ + + +
Sbjct: 62 GLTMLDHEQVTPEDPGAQFLIRTGSVGRNRAEASLERAQNLNPMVD---VKVDTEDIEKK 118
Query: 402 DPSFFSQFTLVIATQLVEDSMVKLDRICREANVMLVFARSYGLTGLVRISVKEHTIIDSK 581
SFF+QF V T D +VK+D+IC + ++ +G G ++ EH ++ K
Sbjct: 119 PESFFTQFDAVCLTCCSRDVIVKVDQICHKNSIKFFTGDVFGYHGYTFANLGEHEFVEEK 178
>sp|Q5NVN7|SAE1_PONAB SUMO-activating enzyme subunit 1 OS=Pongo abelii GN=SAE1
PE=2 SV=2
Length = 346
Score = 95 bits (234), Expect = 4e-019
Identities = 54/180 (30%), Positives = 92/180 (51%), Gaps = 3/180 (1%)
Frame = +3
Query: 42 MERDEQEATMSEPTKTKYDRQLRIWGEVGQAALENASICLLNCGPTGSEALKNLVLGGIG 221
+E++E +SE +YDRQ+R+WG Q L + + L+ G+E KNL+L G+
Sbjct: 2 VEKEEAGGGISEEEAAQYDRQIRLWGLEAQKRLRASRVLLVGLKGLGAEIAKNLILAGVK 61
Query: 222 SITVVDGSKVEIGDLGNNFMLDKNSVGESKAKTVCAFLQELNDAVKANFVEDNPDSLILS 401
+T++D +V D G F++ SVG ++A+ Q LN V V+ + + +
Sbjct: 62 GLTMLDHEQVTPEDPGAQFLIRTGSVGRNRAEASLERAQNLNPMVD---VKVDTEDIEKK 118
Query: 402 DPSFFSQFTLVIATQLVEDSMVKLDRICREANVMLVFARSYGLTGLVRISVKEHTIIDSK 581
SFF+QF V T D +VK+D+IC + ++ +G G ++ EH ++ K
Sbjct: 119 PESFFTQFDAVCLTCCSRDVIVKVDQICHKNSIKFFTGDVFGYHGYTFANLGEHEFVEEK 178
>sp|Q6AXQ0|SAE1_RAT SUMO-activating enzyme subunit 1 OS=Rattus norvegicus
GN=Sae1 PE=2 SV=1
Length = 349
Score = 92 bits (228), Expect = 2e-018
Identities = 50/171 (29%), Positives = 89/171 (52%), Gaps = 3/171 (1%)
Frame = +3
Query: 69 MSEPTKTKYDRQLRIWGEVGQAALENASICLLNCGPTGSEALKNLVLGGIGSITVVDGSK 248
+SE +YDRQ+R+WG Q L + + ++ G+E KNL+L G+ +T++D +
Sbjct: 14 ISEEEAAQYDRQIRLWGLEAQKRLRASRVLIVGMKGLGAEIAKNLILAGVKGLTMLDHEQ 73
Query: 249 VEIGDLGNNFMLDKNSVGESKAKTVCAFLQELNDAVKANFVEDNPDSLILSDPSFFSQFT 428
V DLG F++ SVG+++A+ Q LN V V+ + + + SFF++F
Sbjct: 74 VSPEDLGAQFLIRTGSVGQNRAEASLERAQNLNPMVD---VKVDTEDIEKKPESFFTEFD 130
Query: 429 LVIATQLVEDSMVKLDRICREANVMLVFARSYGLTGLVRISVKEHTIIDSK 581
V T +D ++K+D+IC ++ +G G ++ EH ++ K
Sbjct: 131 AVCLTCCSKDVIIKVDQICHRNSIKFFTGDVFGYHGYTFANLGEHEFVEEK 181
Database: UniProt/SwissProt
Posted date: Sat Aug 07 14:36:18 2010
Number of letters in database: 182,829,261
Number of sequences in database: 518,415
Lambda K H
0.267 0.041 0.140
Gapped
Lambda K H
0.267 0.041 0.140
Matrix: blosum62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 231,464,017,541
Number of Sequences: 518415
Number of Extensions: 231464017541
Number of Successful Extensions: 1443091064
Number of sequences better than 0.0: 0
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