BLASTX 7.6.2
Query= UN72571 /QuerySize=753
(752 letters)
Database: UniProt/SwissProt;
518,415 sequences; 182,829,261 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q54K56|HEXB2_DICDI Beta-hexosaminidase subunit B2 OS=Dictyost... 105 5e-022
sp|Q54SC9|HEXA2_DICDI Beta-hexosaminidase subunit A2 OS=Dictyost... 74 7e-013
sp|Q54K55|HEXB1_DICDI Beta-hexosaminidase subunit B1 OS=Dictyost... 74 1e-012
sp|Q29548|HEXB_PIG Beta-hexosaminidase subunit beta OS=Sus scrof... 70 2e-011
sp|P07686|HEXB_HUMAN Beta-hexosaminidase subunit beta OS=Homo sa... 69 4e-011
sp|P20060|HEXB_MOUSE Beta-hexosaminidase subunit beta OS=Mus mus... 64 1e-009
sp|Q6AXR4|HEXB_RAT Beta-hexosaminidase subunit beta OS=Rattus no... 64 1e-009
sp|Q641X3|HEXA_RAT Beta-hexosaminidase subunit alpha OS=Rattus n... 61 8e-009
sp|P49614|HEXB_FELCA Beta-hexosaminidase subunit beta OS=Felis c... 60 1e-008
sp|Q8WSF3|FDL_DROME Probable beta-hexosaminidase fdl OS=Drosophi... 60 2e-008
sp|Q0V8R6|HEXA_BOVIN Beta-hexosaminidase subunit alpha OS=Bos ta... 58 5e-008
sp|P06865|HEXA_HUMAN Beta-hexosaminidase subunit alpha OS=Homo s... 56 2e-007
sp|Q5RC84|HEXA_PONAB Beta-hexosaminidase subunit alpha OS=Pongo ... 56 2e-007
sp|P29416|HEXA_MOUSE Beta-hexosaminidase subunit alpha OS=Mus mu... 56 3e-007
>sp|Q54K56|HEXB2_DICDI Beta-hexosaminidase subunit B2 OS=Dictyostelium
discoideum GN=hexb2 PE=3 SV=1
Length = 564
Score = 105 bits (260), Expect = 5e-022
Identities = 61/218 (27%), Positives = 115/218 (52%), Gaps = 15/218 (6%)
Frame = +3
Query: 78 LSTEIERERDKMRGIATKISGVAPLFLLFIAGAVSAFEDIEKLRIWPLPAEVNHGGRRMY 257
+ +I +E +K++ I G LL + S+ + + + IWP+P +V +G +Y
Sbjct: 18 IGIKISKEINKIKLNDISIDGE---ILLNKSSDSSSSQSSKIINIWPMPKKVLNGDITVY 74
Query: 258 LSEDFKLVTEGSKYEDPSAILKEGFDRMLAVVRLSHVVSGHRNSSGSDGSSLLQGLHVII 437
+S F+ T +K S LK+ DR ++ +S G S+L + +++
Sbjct: 75 ISPHFQFTTNLTK----STTLKKAMDRYYKLIFT-------EDSKSHSGISILNEIKILV 123
Query: 438 SSSTDELEYGADESYRLVVASQGKPSYAQLEAKSVYGALHGLQTFSQLCHFNMKKKVIEV 617
S + L+ G DESY + + G ++ A++VYGA+ GL+T Q+ F+ +++ ++
Sbjct: 124 KSEDETLQIGFDESYEIYIDDSGDDG-GKIIAETVYGAIRGLETLYQMIGFDYQREYYQI 182
Query: 618 LMTPWNITDQPRFSYRGLLIDASRHYLPLPVMKNVIDS 731
PW I D PR+ +RG+++D SRH+ + V+K I++
Sbjct: 183 KHCPWIIQDSPRYPHRGVMLDTSRHFYSVDVLKEFIEA 220
>sp|Q54SC9|HEXA2_DICDI Beta-hexosaminidase subunit A2 OS=Dictyostelium
discoideum GN=hexa2 PE=3 SV=1
Length = 541
Score = 74 bits (181), Expect = 7e-013
Identities = 43/116 (37%), Positives = 74/116 (63%), Gaps = 7/116 (6%)
Frame = +3
Query: 384 NSSGSDGSSLLQGLHVIISSSTDELEYGADESYRLVVASQGKPSYAQLEAKSVYGALHGL 563
N+ D SS ++ L +II+S + LE G DESY L+V + +Y Q++A ++YGA+ GL
Sbjct: 80 NNVLKDSSSNIE-LSLIIASDDETLELGIDESYFLLV---NQDTY-QIKANTIYGAMRGL 134
Query: 564 QTFSQLCHFNMKKKVIEVLMTPWNITDQPRFSYRGLLIDASRHYLPLPVMKNVIDS 731
+TF Q+ +++ + +T + D P + +RGLL+D +RH+LP ++ ++IDS
Sbjct: 135 ETFKQMVVYDVVEN--SYSLTCAEVVDYPTYQWRGLLVDNARHFLPKNMVLHIIDS 188
>sp|Q54K55|HEXB1_DICDI Beta-hexosaminidase subunit B1 OS=Dictyostelium
discoideum GN=hexb1 PE=3 SV=1
Length = 560
Score = 74 bits (179), Expect = 1e-012
Identities = 40/114 (35%), Positives = 68/114 (59%), Gaps = 6/114 (5%)
Frame = +3
Query: 396 SDGSSLLQGLHVIISSSTDELEYGADESYRLVVASQGKPSYAQLEAKSVYGALHGLQTFS 575
+ S+ L L++ + S + L++G DESY+L++ + ++LE +VYG + GL+TF
Sbjct: 99 NSSSNTLNKLNINLKSKNEILKFGFDESYKLIIKNN---ENSKLEGNTVYGIMRGLETFY 155
Query: 576 QLCHFNMKKK--VIEVLMTPWNITDQPRFSYRGLLIDASRHYLPLPVMKNVIDS 731
QL +N IE + P I D+PRF +RG+++D SRH+ + + VI+S
Sbjct: 156 QLIKYNFSDNSYFIENCL-PLIINDKPRFPHRGVMLDTSRHFYSVDTILKVIES 208
>sp|Q29548|HEXB_PIG Beta-hexosaminidase subunit beta OS=Sus scrofa GN=HEXB PE=1
SV=2
Length = 531
Score = 70 bits (169), Expect = 2e-011
Identities = 60/181 (33%), Positives = 86/181 (47%), Gaps = 12/181 (6%)
Frame = +3
Query: 198 EKLRIWPLPAEVNHGGRRMYLSED--FKLVTEGSKYEDPSAILKEGFDRMLAVVRLSHVV 371
E L +WPLP V+ R ++LS + F + SK IL+E F R +
Sbjct: 28 ESLGLWPLPFAVDISPRSLHLSPNNFFFGHSPTSKAGSSCEILQEAFRRYYDFI--FGFY 85
Query: 372 SGHRNSSGSDGSSLLQGLHVIISSSTDEL-EYGADESYRLVVASQGKPSYAQLEAKSVYG 548
H+ S + LQ L V + S D ++ESY L V K A L A +V+G
Sbjct: 86 KWHQGSYQLCFGTELQQLQVHVESECDTFPSISSNESYVLHV----KGPEALLRANTVWG 141
Query: 549 ALHGLQTFSQLCHFNMKKKVIEVLMTPWNITDQPRFSYRGLLIDASRHYLPLPVMKNVID 728
AL GL+TFSQL + + + I D PRF +RG+LID RH+L + + +D
Sbjct: 142 ALRGLETFSQLIY---QDSYGTFTVNESEIIDFPRFPHRGILIDTGRHFLSVKTIFKTLD 198
Query: 729 S 731
+
Sbjct: 199 A 199
>sp|P07686|HEXB_HUMAN Beta-hexosaminidase subunit beta OS=Homo sapiens GN=HEXB
PE=1 SV=3
Length = 556
Score = 69 bits (166), Expect = 4e-011
Identities = 39/88 (44%), Positives = 54/88 (61%), Gaps = 7/88 (7%)
Frame = +3
Query: 468 ADESYRLVVASQGKPSYAQLEAKSVYGALHGLQTFSQLCHFNMKKKVIEVLMTPWNITDQ 647
+DESY L+V K A L+A V+GAL GL+TFSQL + + + I D
Sbjct: 145 SDESYTLLV----KEPVAVLKANRVWGALRGLETFSQLVY---QDSYGTFTINESTIIDS 197
Query: 648 PRFSYRGLLIDASRHYLPLPVMKNVIDS 731
PRFS+RG+LID SRHYLP+ ++ +D+
Sbjct: 198 PRFSHRGILIDTSRHYLPVKIILKTLDA 225
>sp|P20060|HEXB_MOUSE Beta-hexosaminidase subunit beta OS=Mus musculus GN=Hexb
PE=2 SV=2
Length = 536
Score = 64 bits (154), Expect = 1e-009
Identities = 36/88 (40%), Positives = 54/88 (61%), Gaps = 7/88 (7%)
Frame = +3
Query: 468 ADESYRLVVASQGKPSYAQLEAKSVYGALHGLQTFSQLCHFNMKKKVIEVLMTPWNITDQ 647
+DE+Y L+V + A L+A SV+GAL GL+TFSQL + + + +I D
Sbjct: 124 SDETYSLLV----QEPVAVLKANSVWGALRGLETFSQLVY---QDSFGTFTINESSIADS 176
Query: 648 PRFSYRGLLIDASRHYLPLPVMKNVIDS 731
PRF +RG+LID SRH+LP+ + +D+
Sbjct: 177 PRFPHRGILIDTSRHFLPVKTILKTLDA 204
>sp|Q6AXR4|HEXB_RAT Beta-hexosaminidase subunit beta OS=Rattus norvegicus
GN=Hexb PE=2 SV=1
Length = 537
Score = 64 bits (154), Expect = 1e-009
Identities = 37/88 (42%), Positives = 52/88 (59%), Gaps = 7/88 (7%)
Frame = +3
Query: 468 ADESYRLVVASQGKPSYAQLEAKSVYGALHGLQTFSQLCHFNMKKKVIEVLMTPWNITDQ 647
+DESY L+V + A L+A V+GAL GL+TFSQL + + + I D
Sbjct: 123 SDESYSLLV----QEPVALLKANEVWGALRGLETFSQLVY---QDAYGTFTINESTIADS 175
Query: 648 PRFSYRGLLIDASRHYLPLPVMKNVIDS 731
PRF +RG+LID SRHYLP+ + +D+
Sbjct: 176 PRFPHRGILIDTSRHYLPVKTIFKTLDA 203
>sp|Q641X3|HEXA_RAT Beta-hexosaminidase subunit alpha OS=Rattus norvegicus
GN=Hexa PE=2 SV=1
Length = 528
Score = 61 bits (146), Expect = 8e-009
Identities = 32/68 (47%), Positives = 43/68 (63%), Gaps = 3/68 (4%)
Frame = +3
Query: 525 LEAKSVYGALHGLQTFSQLCHFNMKKKVIEVLMTPWNITDQPRFSYRGLLIDASRHYLPL 704
L +++V+GAL GL+TFSQL K + ITD PRF +RG+L+D SRHYLPL
Sbjct: 127 LSSETVWGALRGLETFSQLV---WKSAEGTFFINKTKITDFPRFPHRGILLDTSRHYLPL 183
Query: 705 PVMKNVID 728
+ N +D
Sbjct: 184 SSILNTLD 191
>sp|P49614|HEXB_FELCA Beta-hexosaminidase subunit beta OS=Felis catus GN=HEXB
PE=2 SV=2
Length = 531
Score = 60 bits (145), Expect = 1e-008
Identities = 35/88 (39%), Positives = 52/88 (59%), Gaps = 7/88 (7%)
Frame = +3
Query: 468 ADESYRLVVASQGKPSYAQLEAKSVYGALHGLQTFSQLCHFNMKKKVIEVLMTPWNITDQ 647
+DESY L+V K A L+A V+G L GL+TFSQL + + + +I D
Sbjct: 119 SDESYTLLV----KEPVAFLKANRVWGVLRGLETFSQLIY---QDSYGTFTVNESDIIDS 171
Query: 648 PRFSYRGLLIDASRHYLPLPVMKNVIDS 731
PRF +RG+LID +RH+LP+ + +D+
Sbjct: 172 PRFPHRGILIDTARHFLPVKSILKTLDA 199
>sp|Q8WSF3|FDL_DROME Probable beta-hexosaminidase fdl OS=Drosophila melanogaster
GN=fdl PE=1 SV=1
Length = 660
Score = 60 bits (143), Expect = 2e-008
Identities = 29/85 (34%), Positives = 47/85 (55%), Gaps = 1/85 (1%)
Frame = +3
Query: 471 DESYRLVVASQGKPSYAQLEAKSVYGALHGLQTFSQLCHFNMKKKVIEVLMTPWNITDQP 650
DE+Y+L ++G ++ A S +GA HGL T QL F+ + ++ + D P
Sbjct: 216 DETYQLSTQTEGHRLQVEIIANSYFGARHGLSTLQQLIWFDDEDHLLHTYANS-KVKDAP 274
Query: 651 RFSYRGLLIDASRHYLPLPVMKNVI 725
+F YRGL++D SRH+ + +K I
Sbjct: 275 KFRYRGLMLDTSRHFFSVESIKRTI 299
>sp|Q0V8R6|HEXA_BOVIN Beta-hexosaminidase subunit alpha OS=Bos taurus GN=HEXA
PE=2 SV=1
Length = 529
Score = 58 bits (139), Expect = 5e-008
Identities = 37/101 (36%), Positives = 60/101 (59%), Gaps = 8/101 (7%)
Frame = +3
Query: 429 VIISSSTDEL-EYGADESYRLVVASQGKPSYAQLEAKSVYGALHGLQTFSQLCHFNMKKK 605
++++ D+ G+ E+Y L + + + L +++V+GAL GL+TFSQL + +
Sbjct: 98 LVVTPGCDQFPSLGSVENYTLTINDE----QSLLLSETVWGALRGLETFSQLI-WRSPEG 152
Query: 606 VIEVLMTPWNITDQPRFSYRGLLIDASRHYLPLPVMKNVID 728
V T +I D PRF +RGLL+D SRHYLPL + + +D
Sbjct: 153 TFYVNKT--DIEDFPRFPHRGLLLDTSRHYLPLASILDTLD 191
>sp|P06865|HEXA_HUMAN Beta-hexosaminidase subunit alpha OS=Homo sapiens GN=HEXA
PE=1 SV=1
Length = 529
Score = 56 bits (134), Expect = 2e-007
Identities = 31/68 (45%), Positives = 42/68 (61%), Gaps = 3/68 (4%)
Frame = +3
Query: 525 LEAKSVYGALHGLQTFSQLCHFNMKKKVIEVLMTPWNITDQPRFSYRGLLIDASRHYLPL 704
L +++V+GAL GL+TFSQL K + I D PRF +RGLL+D SRHYLPL
Sbjct: 127 LLSETVWGALRGLETFSQLV---WKSAEGTFFINKTEIEDFPRFPHRGLLLDTSRHYLPL 183
Query: 705 PVMKNVID 728
+ + +D
Sbjct: 184 SSILDTLD 191
>sp|Q5RC84|HEXA_PONAB Beta-hexosaminidase subunit alpha OS=Pongo abelii GN=HEXA
PE=3 SV=1
Length = 529
Score = 56 bits (134), Expect = 2e-007
Identities = 31/68 (45%), Positives = 42/68 (61%), Gaps = 3/68 (4%)
Frame = +3
Query: 525 LEAKSVYGALHGLQTFSQLCHFNMKKKVIEVLMTPWNITDQPRFSYRGLLIDASRHYLPL 704
L +++V+GAL GL+TFSQL K + I D PRF +RGLL+D SRHYLPL
Sbjct: 127 LLSETVWGALRGLETFSQLV---WKSAEGTFFINKTEIEDFPRFPHRGLLLDTSRHYLPL 183
Query: 705 PVMKNVID 728
+ + +D
Sbjct: 184 SSILDTLD 191
>sp|P29416|HEXA_MOUSE Beta-hexosaminidase subunit alpha OS=Mus musculus GN=Hexa
PE=2 SV=1
Length = 528
Score = 56 bits (133), Expect = 3e-007
Identities = 30/68 (44%), Positives = 42/68 (61%), Gaps = 3/68 (4%)
Frame = +3
Query: 525 LEAKSVYGALHGLQTFSQLCHFNMKKKVIEVLMTPWNITDQPRFSYRGLLIDASRHYLPL 704
L +++V+GAL GL+TFSQL K + I D PRF +RG+L+D SRHYLPL
Sbjct: 127 LASETVWGALRGLETFSQLV---WKSAEGTFFINKTKIKDFPRFPHRGVLLDTSRHYLPL 183
Query: 705 PVMKNVID 728
+ + +D
Sbjct: 184 SSILDTLD 191
Database: UniProt/SwissProt
Posted date: Sat Aug 07 14:36:18 2010
Number of letters in database: 182,829,261
Number of sequences in database: 518,415
Lambda K H
0.267 0.041 0.140
Gapped
Lambda K H
0.267 0.041 0.140
Matrix: blosum62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 239,089,486,026
Number of Sequences: 518415
Number of Extensions: 239089486026
Number of Successful Extensions: 1518758948
Number of sequences better than 0.0: 0
|
