BLASTX 7.6.2

Query= UN74174 /QuerySize=685
        (684 letters)

Database: UniProt/SwissProt;
          518,415 sequences; 182,829,261 total letters
                                                                  Score    E
Sequences producing significant alignments:                       (bits) Value

sp|O59722|FAB1_SCHPO 1-phosphatidylinositol-3-phosphate 5-kinase...    135   3e-031
sp|P34756|FAB1_YEAST 1-phosphatidylinositol-3-phosphate 5-kinase...    133   1e-030
sp|B0G126|FYV1_DICDI 1-phosphatidylinositol-3-phosphate 5-kinase...    131   7e-030
sp|Q9Y2I7|FYV1_HUMAN 1-phosphatidylinositol-3-phosphate 5-kinase...    126   2e-028
sp|Q9Z1T6|FYV1_MOUSE 1-phosphatidylinositol-3-phosphate 5-kinase...    125   3e-028
sp|O96838|FYV1_DROME Putative 1-phosphatidylinositol-3-phosphate...    118   5e-026

>sp|O59722|FAB1_SCHPO 1-phosphatidylinositol-3-phosphate 5-kinase fab1
        OS=Schizosaccharomyces pombe GN=fab1 PE=2 SV=2

          Length = 1932

 Score =  135 bits (339), Expect = 3e-031
 Identities = 64/116 (55%), Positives = 83/116 (71%), Gaps = 2/116 (1%)
 Frame = -2

Query:  683 DKVLLDMNLLETLRTEPIFLGSKAKRSLERAIWNDTNFLASVDVMDYSLLVGFDEERKEL 504
            D+VLLD NL+E +   PIF+  + K  L   +WNDT FL+ +++MDYSL+VG D  +KEL
Sbjct: 1804 DEVLLDENLVELIYESPIFVSEQLKSLLHSCLWNDTLFLSKLNIMDYSLIVGIDYTKKEL 1863

Query:  503 VLGIIDFMRQYTWDKPLETWVKASGILGGPKNASPTIVSPKQYKKSFRKAMTTYFL 336
             +GIIDF+R YTWDK LE+WVK  G++G  +   PTIV+PKQYK  FRKAM  Y L
Sbjct: 1864 YVGIIDFIRTYTWDKKLESWVKEKGLVG--RGPEPTIVTPKQYKNRFRKAMDCYIL 1917

>sp|P34756|FAB1_YEAST 1-phosphatidylinositol-3-phosphate 5-kinase FAB1
        OS=Saccharomyces cerevisiae GN=FAB1 PE=1 SV=1

          Length = 2278

 Score =  133 bits (333), Expect = 1e-030
 Identities = 62/123 (50%), Positives = 86/123 (69%), Gaps = 1/123 (0%)
 Frame = -2

Query:  683 DKVLLDMNLLETLRTEPIFLGSKAKRSLERAIWNDTNFLASVDVMDYSLLVGFDEERKEL 504
            ++VLLD N++E +   PI +    K+ L  ++WNDT FLA ++VMDYSL++G D E   L
Sbjct: 2151 NEVLLDENMVEYIYESPIHVREYDKKLLRASVWNDTLFLAKMNVMDYSLVIGIDNEGYTL 2210

Query:  503 VLGIIDFMRQYTWDKPLETWVKASGILGGPK-NASPTIVSPKQYKKSFRKAMTTYFLTVP 327
             +GIIDF+R +TWDK LE+WVK  G++GG      PT+V+P+QYKK FR+AM  Y L VP
Sbjct: 2211 TVGIIDFIRTFTWDKKLESWVKEKGLVGGASVIKQPTVVTPRQYKKRFREAMERYILMVP 2270

Query:  326 EQW 318
            + W
Sbjct: 2271 DPW 2273

>sp|B0G126|FYV1_DICDI 1-phosphatidylinositol-3-phosphate 5-kinase
        OS=Dictyostelium discoideum GN=pip5k3 PE=3 SV=1

          Length = 2656

 Score =  131 bits (327), Expect = 7e-030
 Identities = 66/122 (54%), Positives = 85/122 (69%), Gaps = 1/122 (0%)
 Frame = -2

Query:  680 KVLLDMNLLETLRTEPIFLGSKAKRSLERAIWNDTNFLASVDVMDYSLLVGFDEERKELV 501
            +VLLD NLL+     PI LG   K  +  A+WNDT FL+S++VMDYSLL G D +  +LV
Sbjct: 2484 EVLLDENLLQASFASPICLGEYDKTRVALAVWNDTAFLSSLNVMDYSLLSGIDNQSNQLV 2543

Query:  500 LGIIDFMRQYTWDKPLETWVKASGILGGPKNASPTIVSPKQYKKSFRKAMTTYFLTVPEQ 321
            +GIID+MR++TWDK LE  VK SGI+GG     PT++SPKQYK  FR AM  YF   P++
Sbjct: 2544 VGIIDYMRKFTWDKALEMKVKQSGIMGGGGKV-PTVISPKQYKLRFRDAMWLYFTLSPDK 2602

Query:  320 WT 315
            +T
Sbjct: 2603 FT 2604

>sp|Q9Y2I7|FYV1_HUMAN 1-phosphatidylinositol-3-phosphate 5-kinase OS=Homo
        sapiens GN=PIKFYVE PE=1 SV=3

          Length = 2098

 Score =  126 bits (314), Expect = 2e-028
 Identities = 63/123 (51%), Positives = 89/123 (72%), Gaps = 1/123 (0%)
 Frame = -2

Query:  683 DKVLLDMNLLETLRTEPIFLGSKAKRSLERAIWNDTNFLASVDVMDYSLLVGFDEERKEL 504
            D VLLD NLL+ +R  P+++ S +K  L  +I +D++FL+S  ++DYSLLVG D+   EL
Sbjct: 1971 DVVLLDENLLKMVRDNPLYIRSHSKAVLRTSIHSDSHFLSSHLIIDYSLLVGRDDTSNEL 2030

Query:  503 VLGIIDFMRQYTWDKPLETWVKASGILGGPKNASPTIVSPKQYKKSFRKAMTTYFLTVPE 324
            V+GIID++R +TWDK LE  VK++GILGG +   PT+VSP+ Y+  F +AM  YFL VP+
Sbjct: 2031 VVGIIDYIRTFTWDKKLEMVVKSTGILGG-QGKMPTVVSPELYRTRFCEAMDKYFLMVPD 2089

Query:  323 QWT 315
             WT
Sbjct: 2090 HWT 2092

>sp|Q9Z1T6|FYV1_MOUSE 1-phosphatidylinositol-3-phosphate 5-kinase OS=Mus
        musculus GN=Pikfyve PE=1 SV=2

          Length = 2097

 Score =  125 bits (313), Expect = 3e-028
 Identities = 63/123 (51%), Positives = 88/123 (71%), Gaps = 1/123 (0%)
 Frame = -2

Query:  683 DKVLLDMNLLETLRTEPIFLGSKAKRSLERAIWNDTNFLASVDVMDYSLLVGFDEERKEL 504
            D VLLD NLL+ +R  P+++ S +K  L  +I +D +FL+S  ++DYSLLVG D+   EL
Sbjct: 1970 DVVLLDENLLKMVRDNPLYIRSHSKSVLRTSIHSDAHFLSSHLIIDYSLLVGRDDTSNEL 2029

Query:  503 VLGIIDFMRQYTWDKPLETWVKASGILGGPKNASPTIVSPKQYKKSFRKAMTTYFLTVPE 324
            V+GIID++R +TWDK LE  VK++GILGG +   PT+VSP+ Y+  F +AM  YFL VP+
Sbjct: 2030 VVGIIDYIRTFTWDKKLEMVVKSTGILGG-QGKMPTVVSPELYRTRFCEAMDKYFLMVPD 2088

Query:  323 QWT 315
             WT
Sbjct: 2089 HWT 2091

>sp|O96838|FYV1_DROME Putative 1-phosphatidylinositol-3-phosphate 5-kinase
        OS=Drosophila melanogaster GN=fab1 PE=1 SV=2

          Length = 1809

 Score =  118 bits (294), Expect = 5e-026
 Identities = 63/126 (50%), Positives = 88/126 (69%), Gaps = 1/126 (0%)
 Frame = -2

Query:  677 VLLDMNLLETLRTEPIFLGSKAKRSLERAIWNDTNFLASVDVMDYSLLVGFDEERKELVL 498
            VLLD NL++   ++P+++ S +K  L  AI  D++FL    VMDYSLLVG D++   LVL
Sbjct: 1685 VLLDENLVQMSWSKPLYVLSHSKTVLRDAIQRDSSFLEKNLVMDYSLLVGLDKKNGVLVL 1744

Query:  497 GIIDFMRQYTWDKPLETWVKASGILGGPKNASPTIVSPKQYKKSFRKAMTTYFLTVPEQW 318
            GIID++R +T DK +E+ +K SGILGG K   PT+V+P++YK+ F  AM  YFLTVP++W
Sbjct: 1745 GIIDYIRTFTLDKRVESIIKGSGILGG-KGKDPTVVNPERYKQRFIDAMDRYFLTVPDRW 1803

Query:  317 TS*IKV 300
                KV
Sbjct: 1804 EGLSKV 1809

  Database: UniProt/SwissProt
    Posted date:  Sat Aug 07 14:36:18 2010
  Number of letters in database: 182,829,261
  Number of sequences in database:  518,415

Lambda     K     H
   0.267   0.041    0.140
Gapped
Lambda     K     H
   0.267   0.041    0.140
Matrix: blosum62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 242,696,336,112
Number of Sequences: 518415
Number of Extensions: 242696336112
Number of Successful Extensions: 1575376966
Number of sequences better than 0.0: 0