BLASTX 7.6.2
Query= UN74334 /QuerySize=708
(707 letters)
Database: UniProt/SwissProt;
518,415 sequences; 182,829,261 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q0P570|ERG19_BOVIN Diphosphomevalonate decarboxylase OS=Bos t... 113 2e-024
sp|P53602|ERG19_HUMAN Diphosphomevalonate decarboxylase OS=Homo ... 111 8e-024
sp|Q99JF5|ERG19_MOUSE Diphosphomevalonate decarboxylase OS=Mus m... 109 3e-023
sp|P32377|ERG19_YEAST Diphosphomevalonate decarboxylase OS=Sacch... 109 3e-023
sp|Q5U403|ERG19_DANRE Diphosphomevalonate decarboxylase OS=Danio... 106 1e-022
sp|Q62967|ERG19_RAT Diphosphomevalonate decarboxylase OS=Rattus ... 104 1e-021
sp|Q6BY07|ERG19_DEBHA Diphosphomevalonate decarboxylase OS=Debar... 99 3e-020
sp|Q54YQ9|ERG19_DICDI Diphosphomevalonate decarboxylase OS=Dicty... 99 3e-020
sp|O13963|ERG19_SCHPO Diphosphomevalonate decarboxylase OS=Schiz... 97 9e-020
sp|Q751D8|ERG19_ASHGO Diphosphomevalonate decarboxylase OS=Ashby... 89 2e-017
>sp|Q0P570|ERG19_BOVIN Diphosphomevalonate decarboxylase OS=Bos taurus GN=MVD
PE=2 SV=1
Length = 400
Score = 113 bits (281), Expect = 2e-024
Identities = 62/127 (48%), Positives = 76/127 (59%), Gaps = 10/127 (7%)
Frame = +1
Query: 79 MAAEKWVHTVTAQTPTNIAVIKYWGKRDEVRILPVNDSISVTLDPDHLCTVTTVAVSPAF 258
MA+EK + VT P NIAV+KYWGKRDE ILP+N S+SVTL D L T TT A+S F
Sbjct: 1 MASEKPIVVVTCTAPVNIAVVKYWGKRDEELILPINSSLSVTLHQDQLKTTTTAAISRDF 60
Query: 259 DRDRMWLNGKEISLSGSGYQNCLREI----RSRGGDVEDKEKGVKIEKKDWERLNLHIAS 426
DR+WLNG+E + Q CLREI R R D + + + K +H+AS
Sbjct: 61 TEDRIWLNGREEDMGHPRLQACLREIRRLARKRRSDGHEDPLPLSLSYK------VHVAS 114
Query: 427 HNNFPTA 447
NNFPTA
Sbjct: 115 ENNFPTA 121
Score = 89 bits (219), Expect = 2e-017
Identities = 40/69 (57%), Positives = 54/69 (78%)
Frame = +2
Query: 446 LSAIARQGSGSACRSLFGGFVKWKMGSKEDGSDSVAVQLADEKHWDDLVIIIAVVSSRQK 625
LS +AR+GSGSACRSL+GGFV+W+MG + DG DSVA Q+A E HW +L ++I VVS+ +K
Sbjct: 148 LSEVARRGSGSACRSLYGGFVEWQMGERPDGKDSVACQVAPESHWPELRVLILVVSAERK 207
Query: 626 *TSSTSGCE 652
ST+G +
Sbjct: 208 PMGSTAGMQ 216
>sp|P53602|ERG19_HUMAN Diphosphomevalonate decarboxylase OS=Homo sapiens GN=MVD
PE=1 SV=1
Length = 400
Score = 111 bits (275), Expect = 8e-024
Identities = 63/131 (48%), Positives = 74/131 (56%), Gaps = 18/131 (13%)
Frame = +1
Query: 79 MAAEKWVHTVTAQTPTNIAVIKYWGKRDEVRILPVNDSISVTLDPDHLCTVTTVAVSPAF 258
MA+EK + VT P NIAVIKYWGKRDE +LP+N S+SVTL D L T TT +S F
Sbjct: 1 MASEKPLAAVTCTAPVNIAVIKYWGKRDEELVLPINSSLSVTLHQDQLKTTTTAVISKDF 60
Query: 259 DRDRMWLNGKEISLSGSGYQNCLREIR--------SRGGDVEDKEKGVKIEKKDWERLNL 414
DR+WLNG+E + Q CLREIR SR GD K+
Sbjct: 61 TEDRIWLNGREEDVGQPRLQACLREIRCLARKRRNSRDGDPLPSSLSCKV---------- 110
Query: 415 HIASHNNFPTA 447
H+AS NNFPTA
Sbjct: 111 HVASVNNFPTA 121
Score = 88 bits (217), Expect = 4e-017
Identities = 40/67 (59%), Positives = 53/67 (79%)
Frame = +2
Query: 446 LSAIARQGSGSACRSLFGGFVKWKMGSKEDGSDSVAVQLADEKHWDDLVIIIAVVSSRQK 625
LS +AR+GSGSACRSL+GGFV+W+MG + DG DS+A Q+A E HW +L ++I VVS+ +K
Sbjct: 148 LSEVARRGSGSACRSLYGGFVEWQMGEQADGKDSIARQVAPESHWPELRVLILVVSAEKK 207
Query: 626 *TSSTSG 646
T ST G
Sbjct: 208 LTGSTVG 214
>sp|Q99JF5|ERG19_MOUSE Diphosphomevalonate decarboxylase OS=Mus musculus GN=Mvd
PE=1 SV=2
Length = 401
Score = 109 bits (270), Expect = 3e-023
Identities = 59/114 (51%), Positives = 68/114 (59%), Gaps = 2/114 (1%)
Frame = +1
Query: 106 VTAQTPTNIAVIKYWGKRDEVRILPVNDSISVTLDPDHLCTVTTVAVSPAFDRDRMWLNG 285
VT P NIAVIKYWGKRDE ILP+N S+SVTL D L T TTVA+S F DR+WLNG
Sbjct: 11 VTCTAPVNIAVIKYWGKRDEALILPINSSLSVTLHQDQLKTTTTVAISKDFTEDRIWLNG 70
Query: 286 KEISLSGSGYQNCLREIRSRGGDVEDKEKGVKIEKKDWERLNLHIASHNNFPTA 447
+E + Q CLREIR E G + +H+AS NNFPTA
Sbjct: 71 REEDVGQPRLQACLREIRRLARKRRSTEDGDTLPLS--LSYKVHVASVNNFPTA 122
Score = 87 bits (213), Expect = 1e-016
Identities = 41/69 (59%), Positives = 53/69 (76%)
Frame = +2
Query: 446 LSAIARQGSGSACRSLFGGFVKWKMGSKEDGSDSVAVQLADEKHWDDLVIIIAVVSSRQK 625
LS +AR+GSGSACRSL+GGFV+W+MG + DG DS+A Q+A E HW L I+I VVS+ +K
Sbjct: 149 LSEVARRGSGSACRSLYGGFVEWQMGEQADGKDSIARQIAPEWHWPQLRILILVVSADKK 208
Query: 626 *TSSTSGCE 652
T ST G +
Sbjct: 209 QTGSTVGMQ 217
>sp|P32377|ERG19_YEAST Diphosphomevalonate decarboxylase OS=Saccharomyces
cerevisiae GN=ERG19 PE=1 SV=2
Length = 396
Score = 109 bits (270), Expect = 3e-023
Identities = 55/117 (47%), Positives = 72/117 (61%), Gaps = 4/117 (3%)
Frame = +1
Query: 97 VHTVTAQTPTNIAVIKYWGKRDEVRILPVNDSISVTLDPDHLCTVTTVAVSPAFDRDRMW 276
V+T + P NIA +KYWGKRD LP N SISVTL D L T+T+ A +P F+RD +W
Sbjct: 3 VYTASVTAPVNIATLKYWGKRDTKLNLPTNSSISVTLSQDDLRTLTSAATAPEFERDTLW 62
Query: 277 LNGKEISLSGSGYQNCLREIRSRGGDVEDKEKGVKIEKKDWERLNLHIASHNNFPTA 447
LNG+ S+ QNCLR++R ++E K+ + W+ LHI S NNFPTA
Sbjct: 63 LNGEPHSIDNERTQNCLRDLRQLRKEMESKDASLP-TLSQWK---LHIVSENNFPTA 115
Score = 84 bits (205), Expect = 1e-015
Identities = 39/70 (55%), Positives = 50/70 (71%)
Frame = +2
Query: 443 QLSAIARQGSGSACRSLFGGFVKWKMGSKEDGSDSVAVQLADEKHWDDLVIIIAVVSSRQ 622
++S IAR+GSGSACRSLFGG+V W+MG EDG DS+AVQ+AD W + + VVS +
Sbjct: 144 EISRIARKGSGSACRSLFGGYVAWEMGKAEDGHDSMAVQIADSSDWPQMKACVLVVSDIK 203
Query: 623 K*TSSTSGCE 652
K SST G +
Sbjct: 204 KDVSSTQGMQ 213
>sp|Q5U403|ERG19_DANRE Diphosphomevalonate decarboxylase OS=Danio rerio GN=mvd
PE=2 SV=1
Length = 400
Score = 106 bits (264), Expect = 1e-022
Identities = 60/114 (52%), Positives = 70/114 (61%), Gaps = 5/114 (4%)
Frame = +1
Query: 106 VTAQTPTNIAVIKYWGKRDEVRILPVNDSISVTLDPDHLCTVTTVAVSPAFDRDRMWLNG 285
VT P NIAVIKYWGKRDE ILPVN S+SVTL DHL T TT+A S +F +D +WLNG
Sbjct: 12 VTCTAPVNIAVIKYWGKRDEDLILPVNASLSVTLHQDHLRTTTTIACSRSFHKDCIWLNG 71
Query: 286 KEISLSGSGYQNCLREIRSRGGDVEDKEKGVKIEKKDWERLNLHIASHNNFPTA 447
KE +S Q+CL EIR + + K D +HI S NNFPTA
Sbjct: 72 KEQDISHPRLQSCLLEIRR----LAQRRKNTGDPASDVSN-KVHICSVNNFPTA 120
Score = 91 bits (225), Expect = 5e-018
Identities = 41/68 (60%), Positives = 54/68 (79%)
Frame = +2
Query: 443 QLSAIARQGSGSACRSLFGGFVKWKMGSKEDGSDSVAVQLADEKHWDDLVIIIAVVSSRQ 622
+LS +ARQGSGSACRSL+GGFV+WK+G + DG DS+A Q+A E +W +L ++I VVS+ Q
Sbjct: 146 ELSGVARQGSGSACRSLYGGFVQWKLGEQSDGKDSIAEQVASELYWPELRVLILVVSAEQ 205
Query: 623 K*TSSTSG 646
K STSG
Sbjct: 206 KSVGSTSG 213
>sp|Q62967|ERG19_RAT Diphosphomevalonate decarboxylase OS=Rattus norvegicus
GN=Mvd PE=2 SV=1
Length = 401
Score = 104 bits (257), Expect = 1e-021
Identities = 57/114 (50%), Positives = 66/114 (57%), Gaps = 2/114 (1%)
Frame = +1
Query: 106 VTAQTPTNIAVIKYWGKRDEVRILPVNDSISVTLDPDHLCTVTTVAVSPAFDRDRMWLNG 285
VT P NIAVIKYWGKRDE ILP+N S+SVTL D L T TT A+S F DR+WLNG
Sbjct: 11 VTCTAPVNIAVIKYWGKRDEALILPINPSLSVTLHQDQLKTTTTAAISKDFTEDRIWLNG 70
Query: 286 KEISLSGSGYQNCLREIRSRGGDVEDKEKGVKIEKKDWERLNLHIASHNNFPTA 447
+E + Q CLREIR G + +H+AS NNFPTA
Sbjct: 71 REEDVGQPRLQACLREIRRLARKRRSTGDGDALPLS--LGYKVHVASVNNFPTA 122
Score = 87 bits (214), Expect = 9e-017
Identities = 40/69 (57%), Positives = 53/69 (76%)
Frame = +2
Query: 446 LSAIARQGSGSACRSLFGGFVKWKMGSKEDGSDSVAVQLADEKHWDDLVIIIAVVSSRQK 625
LS +AR+GSGSACRSL+GGFV+W+MG + DG DS+A Q+A E HW L ++I VVS+ +K
Sbjct: 149 LSEVARRGSGSACRSLYGGFVEWQMGEQADGKDSIARQIAPEWHWPQLRVLILVVSAEKK 208
Query: 626 *TSSTSGCE 652
T ST G +
Sbjct: 209 PTGSTVGMQ 217
>sp|Q6BY07|ERG19_DEBHA Diphosphomevalonate decarboxylase OS=Debaryomyces
hansenii GN=ERG19 PE=3 SV=2
Length = 388
Score = 99 bits (244), Expect = 3e-020
Identities = 51/117 (43%), Positives = 70/117 (59%), Gaps = 4/117 (3%)
Frame = +1
Query: 97 VHTVTAQTPTNIAVIKYWGKRDEVRILPVNDSISVTLDPDHLCTVTTVAVSPAFDRDRMW 276
V+T +A P NIA +KYWGKRD+ LP N SISVTL + L T+T+VA S F D++W
Sbjct: 3 VYTSSATAPVNIATLKYWGKRDKSLNLPTNSSISVTLSQNDLRTLTSVAASEDFKEDKLW 62
Query: 277 LNGKEISLSGSGYQNCLREIRSRGGDVEDKEKGVKIEKKDWERLNLHIASHNNFPTA 447
LNGK SL + CL ++R+ ++E + + + +HI S NNFPTA
Sbjct: 63 LNGKLESLESERTKACLADLRTLRKELESNDSSI----PKLSQFGVHIVSENNFPTA 115
Score = 81 bits (198), Expect = 7e-015
Identities = 40/86 (46%), Positives = 57/86 (66%)
Frame = +2
Query: 443 QLSAIARQGSGSACRSLFGGFVKWKMGSKEDGSDSVAVQLADEKHWDDLVIIIAVVSSRQ 622
++S IAR+GSGSACRSLFGG+V W+MG + +G DS AV++A HW ++ I VVS +
Sbjct: 144 EISKIARKGSGSACRSLFGGYVAWEMGQETNGEDSKAVEVAPLSHWPNMKAAILVVSDDK 203
Query: 623 K*TSSTSGCEKVLRRVCLYSTEQKKL 700
K T STSG + + L+ K++
Sbjct: 204 KDTPSTSGMQTTVATSDLFQWRIKEV 229
>sp|Q54YQ9|ERG19_DICDI Diphosphomevalonate decarboxylase OS=Dictyostelium
discoideum GN=mvd PE=3 SV=1
Length = 391
Score = 99 bits (244), Expect = 3e-020
Identities = 44/70 (62%), Positives = 58/70 (82%)
Frame = +2
Query: 446 LSAIARQGSGSACRSLFGGFVKWKMGSKEDGSDSVAVQLADEKHWDDLVIIIAVVSSRQK 625
+S IAR GSGSACRS++GGFVKW+MG+K+DGSDS+AVQ+ E HW D+ II+ VV+ ++K
Sbjct: 134 ISGIARLGSGSACRSMYGGFVKWEMGTKDDGSDSIAVQVQPESHWPDMNIIVLVVNDKKK 193
Query: 626 *TSSTSGCEK 655
TSST G +K
Sbjct: 194 ETSSTDGMQK 203
Score = 91 bits (223), Expect = 9e-018
Identities = 47/94 (50%), Positives = 60/94 (63%)
Frame = +1
Query: 103 TVTAQTPTNIAVIKYWGKRDEVRILPVNDSISVTLDPDHLCTVTTVAVSPAFDRDRMWLN 282
+VT P NIAVIKYWGKRDE ILP+N S+S TL D L T TT+ S + D ++LN
Sbjct: 5 SVTCTAPVNIAVIKYWGKRDENIILPLNSSLSGTLHQDDLKTTTTIVASEDYTEDELYLN 64
Query: 283 GKEISLSGSGYQNCLREIRSRGGDVEDKEKGVKI 384
GK+ ++ YQN L+ IRSR + DK+ V I
Sbjct: 65 GKKEDINAVRYQNVLKMIRSRATKLMDKKHCVHI 98
>sp|O13963|ERG19_SCHPO Diphosphomevalonate decarboxylase OS=Schizosaccharomyces
pombe GN=erg19 PE=2 SV=1
Length = 393
Score = 97 bits (240), Expect = 9e-020
Identities = 56/124 (45%), Positives = 70/124 (56%), Gaps = 11/124 (8%)
Frame = +1
Query: 88 EKWVHTVTAQTPTNIAVIKYWGKRDEVRILPVNDSISVTLDPDHLCTVTTVAVSPAFDRD 267
+K V+ T P NIAVIKYWGKRD LP N SISVTL D L TVTT + S F+ D
Sbjct: 2 DKKVYQCTVSAPVNIAVIKYWGKRDVALNLPTNSSISVTLSQDDLRTVTTASCSEKFEND 61
Query: 268 RMWLNGK-EISLSGSGYQNCLREIRSRGGDVEDKEKGVKIEKKDWER---LNLHIASHNN 435
+WLNG E + + C+ E+R D+E+ E D ++ L LH+ S NN
Sbjct: 62 TLWLNGNAEEIFANKRLRVCVEELRKARLDLEE-------ENDDLDKIGALKLHVVSENN 114
Query: 436 FPTA 447
FPTA
Sbjct: 115 FPTA 118
Score = 84 bits (205), Expect = 1e-015
Identities = 40/82 (48%), Positives = 56/82 (68%)
Frame = +2
Query: 434 TSLQLSAIARQGSGSACRSLFGGFVKWKMGSKEDGSDSVAVQLADEKHWDDLVIIIAVVS 613
T QLS IARQGSGSACRSLFGG+V W+MG G+DSVAVQ+ ++W ++ + + V S
Sbjct: 144 TPTQLSRIARQGSGSACRSLFGGYVAWEMGELHSGADSVAVQVEPVENWPEIRVAVLVAS 203
Query: 614 SRQK*TSSTSGCEKVLRRVCLY 679
+ +K SST+G + + L+
Sbjct: 204 AAKKGVSSTAGMQATVASSTLF 225
>sp|Q751D8|ERG19_ASHGO Diphosphomevalonate decarboxylase OS=Ashbya gossypii
GN=ERG19 PE=3 SV=1
Length = 372
Score = 89 bits (219), Expect = 2e-017
Identities = 42/79 (53%), Positives = 60/79 (75%)
Frame = +2
Query: 443 QLSAIARQGSGSACRSLFGGFVKWKMGSKEDGSDSVAVQLADEKHWDDLVIIIAVVSSRQ 622
++S IAR+GSGSACRSL+GG+V W+MG++ DGSDS AVQ+AD +HW ++ I VVS+ +
Sbjct: 119 EISKIARKGSGSACRSLYGGYVAWEMGAEADGSDSRAVQIADVEHWPEMRAAILVVSADR 178
Query: 623 K*TSSTSGCEKVLRRVCLY 679
K T STSG ++ + L+
Sbjct: 179 KDTPSTSGMQQTVHTSDLF 197
Score = 73 bits (178), Expect = 1e-012
Identities = 40/91 (43%), Positives = 53/91 (58%), Gaps = 4/91 (4%)
Frame = +1
Query: 175 LPVNDSISVTLDPDHLCTVTTVAVSPAFDRDRMWLNGKEISLSGSGYQNCLREIRSRGGD 354
LP N SISVTL + L T+T+ A P DR+WLNGK SL + Q CL ++R+
Sbjct: 4 LPTNSSISVTLSQEDLRTLTSAATGPELAEDRLWLNGKPESLGNARTQQCLADLRALRRA 63
Query: 355 VEDKEKGVKIEKKDWERLNLHIASHNNFPTA 447
+E +E + +W+ LHI S NNFPTA
Sbjct: 64 LETEEPDLP-RMSEWK---LHIVSENNFPTA 90
Database: UniProt/SwissProt
Posted date: Sat Aug 07 14:36:18 2010
Number of letters in database: 182,829,261
Number of sequences in database: 518,415
Lambda K H
0.267 0.041 0.140
Gapped
Lambda K H
0.267 0.041 0.140
Matrix: blosum62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 243,214,008,525
Number of Sequences: 518415
Number of Extensions: 243214008525
Number of Successful Extensions: 1581329194
Number of sequences better than 0.0: 0
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