BLASTX 7.6.2
Query= UN76526 /QuerySize=648
(647 letters)
Database: UniProt/SwissProt;
518,415 sequences; 182,829,261 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q15751|HERC1_HUMAN Probable E3 ubiquitin-protein ligase HERC1... 91 4e-018
sp|Q9VR91|HERC2_DROME Probable E3 ubiquitin-protein ligase HERC2... 89 3e-017
sp|O95714|HERC2_HUMAN E3 ubiquitin-protein ligase HERC2 OS=Homo ... 84 7e-016
sp|Q4U2R1|HERC2_MOUSE E3 ubiquitin-protein ligase HERC2 OS=Mus m... 81 4e-015
sp|Q8IVU3|HERC6_HUMAN Probable E3 ubiquitin-protein ligase HERC6... 80 1e-014
sp|Q15034|HERC3_HUMAN Probable E3 ubiquitin-protein ligase HERC3... 76 2e-013
sp|Q8SSY6|SPKUL_DICDI Bifunctional serine/threonine-protein kina... 74 5e-013
sp|Q91ZR4|NEK8_MOUSE Serine/threonine-protein kinase Nek8 OS=Mus... 70 8e-012
sp|Q86SG6|NEK8_HUMAN Serine/threonine-protein kinase Nek8 OS=Hom... 68 5e-011
>sp|Q15751|HERC1_HUMAN Probable E3 ubiquitin-protein ligase HERC1 OS=Homo
sapiens GN=HERC1 PE=1 SV=2
Length = 4861
Score = 91 bits (225), Expect = 4e-018
Identities = 41/88 (46%), Positives = 60/88 (68%), Gaps = 2/88 (2%)
Frame = -2
Query: 637 LVDIVAGGWHSTALTEQGEVYAWGRGEHGRLGFGDNDKSSKMVPQKVNLLAVENIIQVSC 458
LV HS ALTE GEV++WG G++G+LG G++D+ + P+++ L E ++Q+SC
Sbjct: 4084 LVTSCGSDGHSMALTESGEVFSWGDGDYGKLGHGNSDRQRR--PRQIEALQGEEVVQMSC 4141
Query: 457 GGTHSVA*TRDGRIFSFGRGDHGRLGYG 374
G HS T DG++F+FG GD+GRLG G
Sbjct: 4142 GFKHSAVVTSDGKLFTFGNGDYGRLGLG 4169
Score = 85 bits (209), Expect = 3e-016
Identities = 42/89 (47%), Positives = 64/89 (71%), Gaps = 5/89 (5%)
Frame = -2
Query: 637 LVDIVAGGWHSTALTEQGEVYAWGRGEHGRLGFGDNDKSSKMVPQKVNLLAVENIIQVSC 458
+V + AG HS A+TE GE+Y WG G+ GRLG GD+ +S+ +P V + N+ +VSC
Sbjct: 513 VVCVSAGYRHSAAVTEDGELYTWGEGDFGRLGHGDS--NSRNIPTLVK--DISNVGEVSC 568
Query: 457 GGTHSVA*TRDGR-IFSFGRGDHGRLGYG 374
G +H++A ++DGR ++SFG GD+G+LG+G
Sbjct: 569 GSSHTIALSKDGRTVWSFGGGDNGKLGHG 597
>sp|Q9VR91|HERC2_DROME Probable E3 ubiquitin-protein ligase HERC2 OS=Drosophila
melanogaster GN=HERC2 PE=1 SV=3
Length = 4912
Score = 89 bits (218), Expect = 3e-017
Identities = 43/99 (43%), Positives = 63/99 (63%), Gaps = 4/99 (4%)
Frame = -2
Query: 631 DIVAGGWHSTALTEQGEVYAWGRGEHGRLGFGDNDKSSKMVPQKVNLLAVENIIQVSCGG 452
D+ G HS A++ QGE+Y WG GE+GRLG GDN ++++ P+ V LA ++QV+CG
Sbjct: 3129 DVACGSSHSAAISSQGELYTWGLGEYGRLGHGDN--TTQLKPKLVTALAGRRVVQVACGS 3186
Query: 451 --THSVA*TRDGRIFSFGRGDHGRLGYGRKVTTGQPSEL 341
++A T DG +FS+G GD G+LG G + P E+
Sbjct: 3187 RDAQTLALTEDGAVFSWGDGDFGKLGRGGSEGSDTPHEI 3225
Score = 79 bits (193), Expect = 2e-014
Identities = 38/95 (40%), Positives = 59/95 (62%), Gaps = 2/95 (2%)
Frame = -2
Query: 634 VDIVAGGWHSTALTEQGEVYAWGRGEHGRLGFGDNDKSSKMVPQKVNLLAVENIIQVSCG 455
V + +GG H+ ALT G+V++WG GE G+LG G+ K P+ V L + I V+CG
Sbjct: 3076 VAVHSGGKHALALTLDGKVFSWGEGEDGKLGHGNRTTLDK--PRLVEALRAKKIRDVACG 3133
Query: 454 GTHSVA*TRDGRIFSFGRGDHGRLGYGRKVTTGQP 350
+HS A + G ++++G G++GRLG+G T +P
Sbjct: 3134 SSHSAAISSQGELYTWGLGEYGRLGHGDNTTQLKP 3168
Score = 77 bits (189), Expect = 6e-014
Identities = 38/87 (43%), Positives = 55/87 (63%), Gaps = 2/87 (2%)
Frame = -2
Query: 634 VDIVAGGWHSTALTEQGEVYAWGRGEHGRLGFGDNDKSSKMVPQKVNLLAVENIIQVSCG 455
V + +GG H ALT +GEVYAWG GE G+LG G ++ S P+ V L ++ ++CG
Sbjct: 4139 VAVNSGGKHCLALTTEGEVYAWGEGEDGKLGHG--NRMSYDRPKLVEHLNGMSVADIACG 4196
Query: 454 GTHSVA*TRDGRIFSFGRGDHGRLGYG 374
HS A T G + ++G+G +GRLG+G
Sbjct: 4197 SAHSAAITASGHVLTWGKGRYGRLGHG 4223
Score = 69 bits (168), Expect = 2e-011
Identities = 34/92 (36%), Positives = 54/92 (58%), Gaps = 4/92 (4%)
Frame = -2
Query: 643 LTLVDIVAGGWHSTALTEQGEVYAWGRGEHGRLGFGDNDKSSKMVPQKVNLLAVENIIQV 464
+++ DI G HS A+T G V WG+G +GRLG GD++ ++ P+ V L I +
Sbjct: 4188 MSVADIACGSAHSAAITASGHVLTWGKGRYGRLGHGDSE--DQLRPKLVEALLGYRAIDI 4245
Query: 463 SCGG--THSVA*TRDGRIFSFGRGDHGRLGYG 374
+CG ++ T D ++S+G GD+G+LG G
Sbjct: 4246 ACGSGDAQTLCITDDDNVWSWGDGDYGKLGRG 4277
>sp|O95714|HERC2_HUMAN E3 ubiquitin-protein ligase HERC2 OS=Homo sapiens
GN=HERC2 PE=1 SV=1
Length = 4834
Score = 84 bits (206), Expect = 7e-016
Identities = 42/88 (47%), Positives = 58/88 (65%), Gaps = 4/88 (4%)
Frame = -2
Query: 631 DIVAGGWHSTALTEQGEVYAWGRGEHGRLGFGDNDKSSKMVPQKVNLLAVENIIQVSCGG 452
DI G HS ALT GE+Y WG GE+GRLG GDN ++++ P+ V +L +IQV+CG
Sbjct: 3103 DIACGSSHSAALTSSGELYTWGLGEYGRLGHGDN--TTQLKPKMVKVLLGHRVIQVACGS 3160
Query: 451 --THSVA*TRDGRIFSFGRGDHGRLGYG 374
++A T +G +FS+G GD G+LG G
Sbjct: 3161 RDAQTLALTDEGLVFSWGDGDFGKLGRG 3188
Score = 78 bits (190), Expect = 5e-014
Identities = 36/100 (36%), Positives = 60/100 (60%), Gaps = 2/100 (2%)
Frame = -2
Query: 634 VDIVAGGWHSTALTEQGEVYAWGRGEHGRLGFGDNDKSSKMVPQKVNLLAVENIIQVSCG 455
V + +GG H+TALT G+V++WG G+ G+LG K P+ + L + I ++CG
Sbjct: 3050 VAVHSGGRHATALTVDGKVFSWGEGDDGKLGHFSRMNCDK--PRLIEALKTKRIRDIACG 3107
Query: 454 GTHSVA*TRDGRIFSFGRGDHGRLGYGRKVTTGQPSELPI 335
+HS A T G ++++G G++GRLG+G T +P + +
Sbjct: 3108 SSHSAALTSSGELYTWGLGEYGRLGHGDNTTQLKPKMVKV 3147
Score = 74 bits (180), Expect = 7e-013
Identities = 34/92 (36%), Positives = 56/92 (60%), Gaps = 4/92 (4%)
Frame = -2
Query: 643 LTLVDIVAGGWHSTALTEQGEVYAWGRGEHGRLGFGDNDKSSKMVPQKVNLLAVENIIQV 464
+ +VD+ AGG HS +T G++Y WG+G +GRLG D++ K P+ V L ++ +
Sbjct: 4091 IEVVDVAAGGAHSACVTAAGDLYTWGKGRYGRLGHSDSEDQLK--PKLVEALQGHRVVDI 4148
Query: 463 SCGG--THSVA*TRDGRIFSFGRGDHGRLGYG 374
+CG ++ T D ++S+G GD+G+LG G
Sbjct: 4149 ACGSGDAQTLCLTDDDTVWSWGDGDYGKLGRG 4180
Score = 74 bits (179), Expect = 9e-013
Identities = 34/83 (40%), Positives = 54/83 (65%), Gaps = 2/83 (2%)
Frame = -2
Query: 616 GWHSTALTEQGEVYAWGRGEHGRLGFGDND--KSSKMVPQKVNLLAVENIIQVSCGGTHS 443
G H AL GEVY+WG G+ GRLG GD + K++ A ++++ ++CG T+S
Sbjct: 504 GHHYLALAATGEVYSWGCGDGGRLGHGDTVPLEEPKVISAFSGKQAGKHVVHIACGSTYS 563
Query: 442 VA*TRDGRIFSFGRGDHGRLGYG 374
A T +G ++++GRG++GRLG+G
Sbjct: 564 AAITAEGELYTWGRGNYGRLGHG 586
Score = 72 bits (176), Expect = 2e-012
Identities = 36/90 (40%), Positives = 57/90 (63%), Gaps = 4/90 (4%)
Frame = -2
Query: 637 LVDIVAGGWHSTALTEQGEVYAWGRGEHGRLGFGDNDKSSKMVPQKVNLLAVENIIQVSC 458
+V I G +S A+T +GE+Y WGRG +GRLG G ++ + +P V L +I V+C
Sbjct: 553 VVHIACGSTYSAAITAEGELYTWGRGNYGRLGHGSSE--DEAIPMLVAGLKGLKVIDVAC 610
Query: 457 GG--THSVA*TRDGRIFSFGRGDHGRLGYG 374
G ++A T +G+++S+G GD+G+LG G
Sbjct: 611 GSGDAQTLAVTENGQVWSWGDGDYGKLGRG 640
>sp|Q4U2R1|HERC2_MOUSE E3 ubiquitin-protein ligase HERC2 OS=Mus musculus
GN=Herc2 PE=1 SV=2
Length = 4836
Score = 81 bits (199), Expect = 4e-015
Identities = 41/88 (46%), Positives = 57/88 (64%), Gaps = 4/88 (4%)
Frame = -2
Query: 631 DIVAGGWHSTALTEQGEVYAWGRGEHGRLGFGDNDKSSKMVPQKVNLLAVENIIQVSCGG 452
DI G HS LT GE+Y WG GE+GRLG GDN ++++ P+ V +L +IQV+CG
Sbjct: 3104 DIAYGSSHSAPLTSSGELYTWGLGEYGRLGHGDN--TTQLKPKMVKVLLGHRVIQVACGS 3161
Query: 451 --THSVA*TRDGRIFSFGRGDHGRLGYG 374
++A T +G +FS+G GD G+LG G
Sbjct: 3162 RDAQTLALTDEGLVFSWGDGDFGKLGRG 3189
Score = 74 bits (181), Expect = 5e-013
Identities = 35/92 (38%), Positives = 56/92 (60%), Gaps = 4/92 (4%)
Frame = -2
Query: 643 LTLVDIVAGGWHSTALTEQGEVYAWGRGEHGRLGFGDNDKSSKMVPQKVNLLAVENIIQV 464
+ +VD+ AGG HS +T G++Y WG+G +GRLG D++ K P+ V L +I +
Sbjct: 4093 IEVVDVAAGGAHSACVTAAGDLYTWGKGRYGRLGHSDSEDQLK--PKLVEALQGHRVIDI 4150
Query: 463 SCGG--THSVA*TRDGRIFSFGRGDHGRLGYG 374
+CG ++ T D ++S+G GD+G+LG G
Sbjct: 4151 ACGSGDAQTLCLTDDDTVWSWGDGDYGKLGRG 4182
Score = 74 bits (179), Expect = 9e-013
Identities = 34/83 (40%), Positives = 54/83 (65%), Gaps = 2/83 (2%)
Frame = -2
Query: 616 GWHSTALTEQGEVYAWGRGEHGRLGFGDND--KSSKMVPQKVNLLAVENIIQVSCGGTHS 443
G H AL GEVY+WG G+ GRLG GD + K++ A ++++ ++CG T+S
Sbjct: 505 GHHYLALAATGEVYSWGCGDGGRLGHGDTVPLEEPKVISAFSGKQAGKHVVHIACGSTYS 564
Query: 442 VA*TRDGRIFSFGRGDHGRLGYG 374
A T +G ++++GRG++GRLG+G
Sbjct: 565 AAITAEGELYTWGRGNYGRLGHG 587
Score = 72 bits (176), Expect = 2e-012
Identities = 36/90 (40%), Positives = 57/90 (63%), Gaps = 4/90 (4%)
Frame = -2
Query: 637 LVDIVAGGWHSTALTEQGEVYAWGRGEHGRLGFGDNDKSSKMVPQKVNLLAVENIIQVSC 458
+V I G +S A+T +GE+Y WGRG +GRLG G ++ + +P V L +I V+C
Sbjct: 554 VVHIACGSTYSAAITAEGELYTWGRGNYGRLGHGSSE--DEAIPMLVAGLKGLKVIDVAC 611
Query: 457 GG--THSVA*TRDGRIFSFGRGDHGRLGYG 374
G ++A T +G+++S+G GD+G+LG G
Sbjct: 612 GSGDAQTLAVTENGQVWSWGDGDYGKLGRG 641
>sp|Q8IVU3|HERC6_HUMAN Probable E3 ubiquitin-protein ligase HERC6 OS=Homo
sapiens GN=HERC6 PE=2 SV=2
Length = 1022
Score = 80 bits (195), Expect = 1e-014
Identities = 40/91 (43%), Positives = 60/91 (65%), Gaps = 2/91 (2%)
Frame = -2
Query: 637 LVDIVA-GGWHSTALTEQGEVYAWGRGEHGRLGFGDNDKSSKMVPQKVNLLAVENIIQVS 461
+VD+V+ G HS A+ +G V+AWG G G+LG G+ K P+K+ L IIQVS
Sbjct: 76 IVDLVSCGKEHSLAVCHKGRVFAWGAGSEGQLGIGE-FKEISFTPKKIMTLNDIKIIQVS 134
Query: 460 CGGTHSVA*TRDGRIFSFGRGDHGRLGYGRK 368
CG HS+A ++D ++FS+G+ HG+LG G++
Sbjct: 135 CGHYHSLALSKDSQVFSWGKNSHGQLGLGKE 165
>sp|Q15034|HERC3_HUMAN Probable E3 ubiquitin-protein ligase HERC3 OS=Homo
sapiens GN=HERC3 PE=1 SV=1
Length = 1050
Score = 76 bits (185), Expect = 2e-013
Identities = 34/93 (36%), Positives = 58/93 (62%), Gaps = 1/93 (1%)
Frame = -2
Query: 646 DLTLVDIVAGGWHSTALTEQGEVYAWGRGEHGRLGFGDNDKSSKMVPQKVNLLAVENIIQ 467
D ++ + G HS AL+++G++++WG G G+LG + S VP+ + L + I+Q
Sbjct: 83 DQHIIHVACGESHSLALSDRGQLFSWGAGSDGQLGLMTTE-DSVAVPRLIQKLNQQTILQ 141
Query: 466 VSCGGTHSVA*TRDGRIFSFGRGDHGRLGYGRK 368
VSCG H +A DG+ F++G+ HG+LG G++
Sbjct: 142 VSCGNWHCLALAADGQFFTWGKNSHGQLGLGKE 174
>sp|Q8SSY6|SPKUL_DICDI Bifunctional serine/threonine-protein kinase/NEDD4-like
E3 ubiquitin-protein ligase OS=Dictyostelium discoideum GN=DDB_G0276527
PE=3 SV=2
Length = 1887
Score = 74 bits (181), Expect = 5e-013
Identities = 36/90 (40%), Positives = 53/90 (58%)
Frame = -2
Query: 643 LTLVDIVAGGWHSTALTEQGEVYAWGRGEHGRLGFGDNDKSSKMVPQKVNLLAVENIIQV 464
+ +V + G S +T++G ++ +GRG+HGRLG G+ + P+ V L II +
Sbjct: 338 IKIVKLSCGTNRSAVITDKGLLFTFGRGDHGRLGLGEQSLLMQSTPKLVQSLQGHFIIDM 397
Query: 463 SCGGTHSVA*TRDGRIFSFGRGDHGRLGYG 374
S GG HS+ T G +FSFGR D G+LG G
Sbjct: 398 SSGGGHSLVLTNKGLVFSFGRNDQGQLGIG 427
>sp|Q91ZR4|NEK8_MOUSE Serine/threonine-protein kinase Nek8 OS=Mus musculus
GN=Nek8 PE=1 SV=1
Length = 698
Score = 70 bits (171), Expect = 8e-012
Identities = 38/111 (34%), Positives = 63/111 (56%), Gaps = 3/111 (2%)
Frame = -2
Query: 643 LTLVDIVAGGWHSTALTEQGEVYAWGRGEHGRLGFGDNDKSSKMVPQKVNLLAVENIIQV 464
+T+ + G + LT++G + +G G +G LG G+ S+ P V L ++QV
Sbjct: 397 VTIKHVACGDLFTACLTDRGIIMTFGSGSNGCLGHGNLTDISQ--PTIVEALLGYEMVQV 454
Query: 463 SCGGTHSVA*TRDGRIFSFGRGDHGRLGYGRKVTTGQPSELPIEIPPPEGQ 311
+CG +H +A + DG +F++GRGD GRLG G + + P ++P+ P E Q
Sbjct: 455 ACGASHVLALSTDGELFAWGRGDGGRLGLGTRESHNCPQQVPV-APGQEAQ 504
>sp|Q86SG6|NEK8_HUMAN Serine/threonine-protein kinase Nek8 OS=Homo sapiens
GN=NEK8 PE=1 SV=1
Length = 692
Score = 68 bits (164), Expect = 5e-011
Identities = 37/111 (33%), Positives = 61/111 (54%), Gaps = 6/111 (5%)
Frame = -2
Query: 643 LTLVDIVAGGWHSTALTEQGEVYAWGRGEHGRLGFGDNDKSSKMVPQKVNLLAVENIIQV 464
+T+ + G + + LT++G + +G G +G LG G S+ P V L ++QV
Sbjct: 391 VTIKHVACGDFFTACLTDRGIIMTFGSGSNGCLGHGSLTDISQ--PTIVEALLGYEMVQV 448
Query: 463 SCGGTHSVA*TRDGRIFSFGRGDHGRLGYGRKVTTGQPSELPIEIPPPEGQ 311
+CG +H +A + + +F++GRGD GRLG G T + P ++P P GQ
Sbjct: 449 ACGASHVLALSTERELFAWGRGDSGRLGLG----TRESHSCPQQVPMPPGQ 495
Database: UniProt/SwissProt
Posted date: Sat Aug 07 14:36:18 2010
Number of letters in database: 182,829,261
Number of sequences in database: 518,415
Lambda K H
0.267 0.041 0.140
Gapped
Lambda K H
0.267 0.041 0.140
Matrix: blosum62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 249,981,154,389
Number of Sequences: 518415
Number of Extensions: 249981154389
Number of Successful Extensions: 1620631332
Number of sequences better than 0.0: 0
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