BLASTX 7.6.2
Query= UN80568 /QuerySize=756
(755 letters)
Database: UniProt/SwissProt;
518,415 sequences; 182,829,261 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q5F389|WWOX_CHICK WW domain-containing oxidoreductase OS=Gall... 99 2e-020
sp|Q9NZC7|WWOX_HUMAN WW domain-containing oxidoreductase OS=Homo... 98 5e-020
sp|Q91WL8|WWOX_MOUSE WW domain-containing oxidoreductase OS=Mus ... 98 6e-020
sp|Q8VBZ0|DHRSX_MOUSE Dehydrogenase/reductase SDR family member ... 97 8e-020
sp|Q5R9W5|WWOX_PONAB WW domain-containing oxidoreductase OS=Pong... 97 1e-019
sp|Q8N5I4|DHRSX_HUMAN Dehydrogenase/reductase SDR family member ... 94 1e-018
sp|Q803A8|WWOX_DANRE WW domain-containing oxidoreductase OS=Dani... 93 1e-018
sp|O74959|YJCD_SCHPO Uncharacterized oxidoreductase C736.13 OS=S... 85 4e-016
sp|Q9VLU5|WWOX_DROME WW domain-containing oxidoreductase OS=Dros... 69 4e-011
sp|O32291|YXNA_BACSU Uncharacterized oxidoreductase yxnA OS=Baci... 55 4e-007
>sp|Q5F389|WWOX_CHICK WW domain-containing oxidoreductase OS=Gallus gallus
GN=WWOX PE=2 SV=2
Length = 414
Score = 99 bits (246), Expect = 2e-020
Identities = 59/133 (44%), Positives = 78/133 (58%), Gaps = 6/133 (4%)
Frame = +3
Query: 222 IVTGSTSGIGRETARQLAEAGAHVVMAVRNTKAAQELIQQWQNEWSGRGLPLNIEAMELD 401
I+TG+ SGIG ETA+ A GA+V++A RN + +Q+ EW +EAM LD
Sbjct: 128 IITGANSGIGFETAKSFALHGAYVILACRNMSRGNDAVQRILEEWH----KAKVEAMTLD 183
Query: 402 LLSLASVARFADAWNARLGPLHVLINNAGIFAMGEAQKFSEDGYEQHMQVNHLAPSLLSV 581
L SL SV FA+A+ ++ PLH+L+ NA IF G + +EDG E QVNHL L
Sbjct: 184 LASLRSVQNFAEAFKSKNMPLHILVCNAAIF--GSSWCLTEDGLESTFQVNHLGHFYLVQ 241
Query: 582 LLLPSLIRGSPSR 620
LL L R SP+R
Sbjct: 242 LLEDILRRSSPAR 254
>sp|Q9NZC7|WWOX_HUMAN WW domain-containing oxidoreductase OS=Homo sapiens
GN=WWOX PE=1 SV=1
Length = 414
Score = 98 bits (243), Expect = 5e-020
Identities = 59/136 (43%), Positives = 78/136 (57%), Gaps = 6/136 (4%)
Frame = +3
Query: 222 IVTGSTSGIGRETARQLAEAGAHVVMAVRNTKAAQELIQQWQNEWSGRGLPLNIEAMELD 401
+VTG+ SGIG ETA+ A GAHV++A RN A E + + EW +EAM LD
Sbjct: 128 VVTGANSGIGFETAKSFALHGAHVILACRNMARASEAVSRILEEWH----KAKVEAMTLD 183
Query: 402 LLSLASVARFADAWNARLGPLHVLINNAGIFAMGEAQKFSEDGYEQHMQVNHLAPSLLSV 581
L L SV FA+A+ A+ PLHVL+ NA FA+ ++DG E QVNHL L
Sbjct: 184 LALLRSVQHFAEAFKAKNVPLHVLVCNAATFAL--PWSLTKDGLETTFQVNHLGHFYLVQ 241
Query: 582 LLLPSLIRGSPSRSLM 629
LL L R +P+R ++
Sbjct: 242 LLQDVLCRSAPARVIV 257
>sp|Q91WL8|WWOX_MOUSE WW domain-containing oxidoreductase OS=Mus musculus
GN=Wwox PE=1 SV=1
Length = 414
Score = 98 bits (242), Expect = 6e-020
Identities = 60/136 (44%), Positives = 78/136 (57%), Gaps = 6/136 (4%)
Frame = +3
Query: 222 IVTGSTSGIGRETARQLAEAGAHVVMAVRNTKAAQELIQQWQNEWSGRGLPLNIEAMELD 401
+VTG+ SGIG ETA+ A GAHV++A RN A E + + EW +EAM LD
Sbjct: 128 LVTGANSGIGFETAKSFALHGAHVILACRNLSRASEAVSRILEEWH----KAKVEAMTLD 183
Query: 402 LLSLASVARFADAWNARLGPLHVLINNAGIFAMGEAQKFSEDGYEQHMQVNHLAPSLLSV 581
L L SV FA+A+ A+ LHVL+ NAG FA+ ++DG E QVNHL L
Sbjct: 184 LAVLRSVQHFAEAFKAKNVSLHVLVCNAGTFAL--PWGLTKDGLETTFQVNHLGHFYLVQ 241
Query: 582 LLLPSLIRGSPSRSLM 629
LL L R SP+R ++
Sbjct: 242 LLQDVLCRSSPARVIV 257
>sp|Q8VBZ0|DHRSX_MOUSE Dehydrogenase/reductase SDR family member on chromosome X
homolog OS=Mus musculus GN=Dhrsx PE=2 SV=2
Length = 335
Score = 97 bits (241), Expect = 8e-020
Identities = 62/138 (44%), Positives = 82/138 (59%), Gaps = 6/138 (4%)
Frame = +3
Query: 186 PLPLPPVNDLTCIVTGSTSGIGRETARQLAEAGAHVVMAVRNTKAAQELIQQWQNEWSGR 365
P LPP IVTG+T+GIGR TARQLA G VV+A + QE++ + E
Sbjct: 35 PPVLPPQPGRVAIVTGATAGIGRSTARQLARLGMCVVVAGNDEHRGQEVVSSIRAEMGSD 94
Query: 366 GLPLNIEAMELDLLSLASVARFADAWNARLGPLHVLINNAGIFAMGEAQKFSEDGYEQHM 545
+ LDL SLASV FA + A PLH+L+NNAG+ M E + +EDG+E+H+
Sbjct: 95 ----RAHFLPLDLASLASVRGFARDFQALGLPLHLLVNNAGV--MLEPRAETEDGFERHL 148
Query: 546 QVNHLAPSLLSVLLLPSL 599
VN L LL++LLLP+L
Sbjct: 149 GVNFLGHFLLTLLLLPAL 166
>sp|Q5R9W5|WWOX_PONAB WW domain-containing oxidoreductase OS=Pongo abelii
GN=WWOX PE=2 SV=1
Length = 414
Score = 97 bits (239), Expect = 1e-019
Identities = 58/136 (42%), Positives = 78/136 (57%), Gaps = 6/136 (4%)
Frame = +3
Query: 222 IVTGSTSGIGRETARQLAEAGAHVVMAVRNTKAAQELIQQWQNEWSGRGLPLNIEAMELD 401
+VTG+ SGIG ETA+ A GAHV++A RN A E + + EW +EA+ LD
Sbjct: 128 VVTGANSGIGFETAKSFALHGAHVILACRNMARASEAVSRILEEWH----KAKVEAVTLD 183
Query: 402 LLSLASVARFADAWNARLGPLHVLINNAGIFAMGEAQKFSEDGYEQHMQVNHLAPSLLSV 581
L L SV FA+A+ A+ PLHVL+ NA FA+ ++DG E QVNHL L
Sbjct: 184 LALLRSVQHFAEAFKAKNVPLHVLVCNAATFAL--PWSLTKDGLETTFQVNHLGHFYLVQ 241
Query: 582 LLLPSLIRGSPSRSLM 629
LL L R +P+R ++
Sbjct: 242 LLQDVLCRSAPARVIV 257
>sp|Q8N5I4|DHRSX_HUMAN Dehydrogenase/reductase SDR family member on chromosome X
OS=Homo sapiens GN=DHRSX PE=2 SV=2
Length = 330
Score = 94 bits (231), Expect = 1e-018
Identities = 57/143 (39%), Positives = 82/143 (57%), Gaps = 7/143 (4%)
Frame = +3
Query: 198 PPVNDLTCIVTGSTSGIGRETARQLAEAGAHVVMAVRNTKAAQELIQQWQNEWSGRGLPL 377
PP D IVTG T GIG TA+ LA G HV++A N A++++ + + E L
Sbjct: 39 PPRPDRVAIVTGGTDGIGYSTAKHLARLGMHVIIAGNNDSKAKQVVSKIKEE----TLND 94
Query: 378 NIEAMELDLLSLASVARFADAWNARLGPLHVLINNAGIFAMGEAQKFSEDGYEQHMQVNH 557
+E + DL S+ S+ +F + + PLHVLINNAG+ M Q+ + DG+E+H +N+
Sbjct: 95 KVEFLYCDLASMTSIRQFVQKFKMKKIPLHVLINNAGV--MMVPQRKTRDGFEEHFGLNY 152
Query: 558 LAPSLLSVLLLPSLIR-GSPSRS 623
L LL+ LLL +L GSP S
Sbjct: 153 LGHFLLTNLLLDTLKESGSPGHS 175
>sp|Q803A8|WWOX_DANRE WW domain-containing oxidoreductase OS=Danio rerio GN=wwox
PE=2 SV=1
Length = 412
Score = 93 bits (230), Expect = 1e-018
Identities = 57/139 (41%), Positives = 77/139 (55%), Gaps = 6/139 (4%)
Frame = +3
Query: 204 VNDLTCIVTGSTSGIGRETARQLAEAGAHVVMAVRNTKAAQELIQQWQNEWSGRGLPLNI 383
++D IVTG+ SGIG ETAR A GAHV++A RN A + EWS +
Sbjct: 119 LSDKVIIVTGANSGIGFETARSFALHGAHVILACRNQSRASKAASLIMGEWS----KARV 174
Query: 384 EAMELDLLSLASVARFADAWNARLGPLHVLINNAGIFAMGEAQKFSEDGYEQHMQVNHLA 563
E + LDL SL SV +FA+ + A PLHVL+ NA + + + +EDG+E Q+ HL
Sbjct: 175 EVLPLDLASLRSVRQFAELFKATKLPLHVLVCNAAV--CSQPWRLTEDGFESTFQICHLG 232
Query: 564 PSLLSVLLLPSLIRGSPSR 620
LL LL L +P+R
Sbjct: 233 HFLLVQLLQDVLRLSAPAR 251
>sp|O74959|YJCD_SCHPO Uncharacterized oxidoreductase C736.13
OS=Schizosaccharomyces pombe GN=SPCC736.13 PE=2 SV=1
Length = 339
Score = 85 bits (209), Expect = 4e-016
Identities = 53/137 (38%), Positives = 81/137 (59%), Gaps = 6/137 (4%)
Frame = +3
Query: 195 LPPVNDLTCIVTGSTSGIGRETARQLAEAGAHVVMAVRNTKAAQELIQQWQNEWSGRGLP 374
+P + +VTGS+ GIG TA +LA GA V +A RN + Q++++Q +E
Sbjct: 37 IPDLTGKVALVTGSSGGIGYVTALELARKGAKVYLAGRNEEKYQKVMKQIHDEVRHS--- 93
Query: 375 LNIEAMELDLLSLASVARFADAWNARLGPLHVLINNAGIFAMGEAQKFSEDGYEQHMQVN 554
I + LDLL SV + A+++ A+ LH+L+NNAGI M + ++DGYE +Q N
Sbjct: 94 -KIRFLRLDLLDFESVYQAAESFIAKEEKLHILVNNAGI--MNPPFELTKDGYELQIQTN 150
Query: 555 HLAPSLLSVLLLPSLIR 605
+L+ L + LLLP+L R
Sbjct: 151 YLSHYLFTELLLPTLRR 167
>sp|Q9VLU5|WWOX_DROME WW domain-containing oxidoreductase OS=Drosophila
melanogaster GN=Wwox PE=2 SV=1
Length = 409
Score = 69 bits (166), Expect = 4e-011
Identities = 45/124 (36%), Positives = 65/124 (52%), Gaps = 4/124 (3%)
Frame = +3
Query: 216 TCIVTGSTSGIGRETARQLAEAGAHVVMAVRNTKAAQELIQQWQNEWSGRGLPLNIEAME 395
T ++TG+ GIG ETAR LA G ++ A RN +A+ I++ E A
Sbjct: 123 TALITGANCGIGYETARSLAHHGCEIIFACRNRSSAEAAIERIAQERPAARSRCRFAA-- 180
Query: 396 LDLLSLASVARFADAWNARLGPLHVLINNAGIFAMGEAQKFSEDGYEQHMQVNHLAPSLL 575
LDL SL SV RF + + + LI NAG+FA+ + + DG E QV+HL+ L
Sbjct: 181 LDLSSLRSVQRFVEEIKQSVSHIDYLILNAGVFALPYTR--TVDGLETTFQVSHLSHFYL 238
Query: 576 SVLL 587
++ L
Sbjct: 239 TLQL 242
>sp|O32291|YXNA_BACSU Uncharacterized oxidoreductase yxnA OS=Bacillus subtilis
GN=yxnA PE=3 SV=2
Length = 356
Score = 55 bits (131), Expect = 4e-007
Identities = 36/130 (27%), Positives = 60/130 (46%), Gaps = 6/130 (4%)
Frame = +3
Query: 177 LQNPLPLPPVNDLTCIVTGSTSGIGRETARQLAEAGAHVVMAVRNTKAAQELIQQWQNEW 356
++ L L + D ++TG++SGIG TAR AE GA VV A RN +A +EL + + +
Sbjct: 20 IKTKLKLKKLKDQVIVITGASSGIGLVTARMAAEKGAKVVAAARNEEALKELTDELKEKG 79
Query: 357 SGRGLPLNIEAMELDLLSLASVARFADAWNARLGPLHVLINNAGIFAMGEAQKFSEDGYE 536
+ ++ D+ V R A+ + G +NNA + G A + + +
Sbjct: 80 H------DAIWVKADVGKEEDVNRIAETAISTFGRFDTWVNNAAVSTFGHAMDVTVEDMK 133
Query: 537 QHMQVNHLAP 566
+ N P
Sbjct: 134 RMFDTNFWGP 143
Database: UniProt/SwissProt
Posted date: Sat Aug 07 14:36:18 2010
Number of letters in database: 182,829,261
Number of sequences in database: 518,415
Lambda K H
0.267 0.041 0.140
Gapped
Lambda K H
0.267 0.041 0.140
Matrix: blosum62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 256,370,568,157
Number of Sequences: 518415
Number of Extensions: 256370568157
Number of Successful Extensions: 1656380741
Number of sequences better than 0.0: 0
|
