BLASTX 7.6.2
Query= UN06776 /QuerySize=951
(950 letters)
Database: UniProt/SwissProt;
518,415 sequences; 182,829,261 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|O81027|HMGCL_ARATH Hydroxymethylglutaryl-CoA lyase, mitochond... 168 5e-041
sp|Q29448|HMGCL_BOVIN Hydroxymethylglutaryl-CoA lyase, mitochond... 122 3e-027
sp|P97519|HMGCL_RAT Hydroxymethylglutaryl-CoA lyase, mitochondri... 122 6e-027
sp|P35915|HMGCL_CHICK Hydroxymethylglutaryl-CoA lyase OS=Gallus ... 121 1e-026
sp|P38060|HMGCL_MOUSE Hydroxymethylglutaryl-CoA lyase, mitochond... 117 1e-025
sp|Q8TB92|HMGC2_HUMAN Probable 3-hydroxymethyl-3-methylglutaryl-... 116 2e-025
sp|Q8JZS7|HMGC2_MOUSE Probable 3-hydroxymethyl-3-methylglutaryl-... 116 3e-025
sp|Q5R9E1|HMGCL_PONAB Hydroxymethylglutaryl-CoA lyase, mitochond... 114 9e-025
sp|Q8HXZ6|HMGCL_MACFA Hydroxymethylglutaryl-CoA lyase, mitochond... 114 1e-024
sp|P35914|HMGCL_HUMAN Hydroxymethylglutaryl-CoA lyase, mitochond... 113 3e-024
sp|A8WG57|HMGC2_DANRE Probable 3-hydroxymethyl-3-methylglutaryl-... 112 6e-024
sp|P13703|HMGCL_PSEMV Hydroxymethylglutaryl-CoA lyase OS=Pseudom... 81 8e-015
sp|O34873|HMGCL_BACSU Hydroxymethylglutaryl-CoA lyase yngG OS=Ba... 78 9e-014
>sp|O81027|HMGCL_ARATH Hydroxymethylglutaryl-CoA lyase, mitochondrial
OS=Arabidopsis thaliana GN=HMGCL PE=1 SV=2
Length = 468
Score = 168 bits (425), Expect = 5e-041
Identities = 91/112 (81%), Positives = 101/112 (90%), Gaps = 2/112 (1%)
Frame = +3
Query: 576 HQLLREVPKFVKIVEVGPRDGLQNEKNIVPTSVKVELIRRLVSAGLPVVEATSFVSPKWV 755
+++ + +PKFVKIVEVGPRDGLQNEKNIVPTSVKVELI+RLVS+GLPVVEATSFVSPKWV
Sbjct: 158 NKISKGIPKFVKIVEVGPRDGLQNEKNIVPTSVKVELIQRLVSSGLPVVEATSFVSPKWV 217
Query: 756 PQLADAKNVMDAVNTLHGAARLPVLTPNLKGLK-QLSLQC*EVAIFASASES 908
PQLADAK+VMDAVNTL G ARLPVLTPNLKG + +S EVAIFASASES
Sbjct: 218 PQLADAKDVMDAVNTLDG-ARLPVLTPNLKGFQAAVSAGAKEVAIFASASES 268
Score = 64 bits (153), Expect = 2e-009
Identities = 33/49 (67%), Positives = 38/49 (77%), Gaps = 2/49 (4%)
Frame = +3
Query: 279 MQRNGMRRAHSLWCKSLTNNLHHHHHPSIPVT-TTTMSSLEELSSIDRI 422
MQ NG+RRAHS+WCK LTNN H HHPSIPV+ TMSSLEE S D++
Sbjct: 1 MQWNGVRRAHSIWCKRLTNNT-HLHHPSIPVSHFFTMSSLEEPLSFDKL 48
>sp|Q29448|HMGCL_BOVIN Hydroxymethylglutaryl-CoA lyase, mitochondrial OS=Bos
taurus GN=HMGCL PE=2 SV=2
Length = 325
Score = 122 bits (306), Expect = 3e-027
Identities = 67/104 (64%), Positives = 76/104 (73%), Gaps = 2/104 (1%)
Frame = +3
Query: 597 PKFVKIVEVGPRDGLQNEKNIVPTSVKVELIRRLVSAGLPVVEATSFVSPKWVPQLADAK 776
PK VKIVEVGPRDGLQNEKNIVPT VK++LI L AGLPVVEATSFVSPKWVPQ+AD
Sbjct: 30 PKQVKIVEVGPRDGLQNEKNIVPTPVKIKLIDMLSEAGLPVVEATSFVSPKWVPQMADHA 89
Query: 777 NVMDAVNTLHGAARLPVLTPNLKGLK-QLSLQC*EVAIFASASE 905
V+ + G PVLTPN KG + ++ EVAIF +ASE
Sbjct: 90 EVLKGIQKFPG-VNYPVLTPNFKGFQAAVAAGAKEVAIFGAASE 132
>sp|P97519|HMGCL_RAT Hydroxymethylglutaryl-CoA lyase, mitochondrial OS=Rattus
norvegicus GN=Hmgcl PE=2 SV=1
Length = 325
Score = 122 bits (304), Expect = 6e-027
Identities = 64/105 (60%), Positives = 80/105 (76%), Gaps = 2/105 (1%)
Frame = +3
Query: 594 VPKFVKIVEVGPRDGLQNEKNIVPTSVKVELIRRLVSAGLPVVEATSFVSPKWVPQLADA 773
+PK VKIVEVGPRDGLQNEK+IVPT VK++LI L AGLPV+EATSFVSPKWVPQ+AD
Sbjct: 29 LPKRVKIVEVGPRDGLQNEKSIVPTPVKIKLIDMLSEAGLPVIEATSFVSPKWVPQMADH 88
Query: 774 KNVMDAVNTLHGAARLPVLTPNLKGLKQ-LSLQC*EVAIFASASE 905
+V+ + G PVLTPN+KG ++ ++ EV+IF +ASE
Sbjct: 89 SDVLKGIQKFPG-INYPVLTPNMKGFEEAVAAGAKEVSIFGAASE 132
>sp|P35915|HMGCL_CHICK Hydroxymethylglutaryl-CoA lyase OS=Gallus gallus GN=HMGCL
PE=1 SV=1
Length = 298
Score = 121 bits (302), Expect = 1e-026
Identities = 63/104 (60%), Positives = 78/104 (75%), Gaps = 2/104 (1%)
Frame = +3
Query: 597 PKFVKIVEVGPRDGLQNEKNIVPTSVKVELIRRLVSAGLPVVEATSFVSPKWVPQLADAK 776
P+ VK+VEVGPRDGLQNEK++VPT VK+ LI L GLPV+EATSFVSP+WVPQ+AD
Sbjct: 3 PQRVKVVEVGPRDGLQNEKSVVPTPVKIRLIDMLSETGLPVIEATSFVSPRWVPQMADHA 62
Query: 777 NVMDAVNTLHGAARLPVLTPNLKGLK-QLSLQC*EVAIFASASE 905
VM +N L G + PVLTPNLKG + ++ EV+IF +ASE
Sbjct: 63 EVMQGINKLPGVS-YPVLTPNLKGFQAAVAAGAKEVSIFGAASE 105
>sp|P38060|HMGCL_MOUSE Hydroxymethylglutaryl-CoA lyase, mitochondrial OS=Mus
musculus GN=Hmgcl PE=1 SV=1
Length = 325
Score = 117 bits (293), Expect = 1e-025
Identities = 61/105 (58%), Positives = 77/105 (73%), Gaps = 2/105 (1%)
Frame = +3
Query: 594 VPKFVKIVEVGPRDGLQNEKNIVPTSVKVELIRRLVSAGLPVVEATSFVSPKWVPQLADA 773
+PK VKIVEVGPRDGLQNEK+IVPT VK+ LI L AGLPV+EATSFVSP WVPQ+AD
Sbjct: 29 LPKQVKIVEVGPRDGLQNEKSIVPTPVKIRLIDMLSEAGLPVIEATSFVSPNWVPQMADH 88
Query: 774 KNVMDAVNTLHGAARLPVLTPNLKGLKQ-LSLQC*EVAIFASASE 905
+V+ + G PVLTPN+KG ++ ++ EV++F + SE
Sbjct: 89 SDVLKGIQKFPG-INYPVLTPNMKGFEEAVAAGAKEVSVFGAVSE 132
>sp|Q8TB92|HMGC2_HUMAN Probable 3-hydroxymethyl-3-methylglutaryl-CoA lyase 2
OS=Homo sapiens GN=HMGCLL1 PE=2 SV=3
Length = 370
Score = 116 bits (290), Expect = 2e-025
Identities = 61/109 (55%), Positives = 77/109 (70%), Gaps = 2/109 (1%)
Frame = +3
Query: 585 LREVPKFVKIVEVGPRDGLQNEKNIVPTSVKVELIRRLVSAGLPVVEATSFVSPKWVPQL 764
L +P+FVKIVEVGPRDGLQNEK IVPT +K+E I RL GL V+E TSFVS +WVPQ+
Sbjct: 71 LSGLPEFVKIVEVGPRDGLQNEKVIVPTDIKIEFINRLSQTGLSVIEVTSFVSSRWVPQM 130
Query: 765 ADAKNVMDAVNTLHGAARLPVLTPNLKGLKQ-LSLQC*EVAIFASASES 908
AD VM ++ G R PVLTPNL+G ++ E+++F +ASES
Sbjct: 131 ADHTEVMKGIHQYPG-VRYPVLTPNLQGFHHAVAAGATEISVFGAASES 178
>sp|Q8JZS7|HMGC2_MOUSE Probable 3-hydroxymethyl-3-methylglutaryl-CoA lyase 2
OS=Mus musculus GN=Hmgcll1 PE=2 SV=1
Length = 343
Score = 116 bits (289), Expect = 3e-025
Identities = 60/106 (56%), Positives = 77/106 (72%), Gaps = 2/106 (1%)
Frame = +3
Query: 594 VPKFVKIVEVGPRDGLQNEKNIVPTSVKVELIRRLVSAGLPVVEATSFVSPKWVPQLADA 773
+P++VKIVEVGPRDGLQNEK IVPT +K+ELI +L GL V+E TSFVS +WVPQ+AD
Sbjct: 44 LPEYVKIVEVGPRDGLQNEKVIVPTDIKIELINQLSQTGLSVIEVTSFVSSRWVPQMADH 103
Query: 774 KNVMDAVNTLHGAARLPVLTPNLKGLKQ-LSLQC*EVAIFASASES 908
VM + G R PVLTPNL+G + ++ E+A+F +ASES
Sbjct: 104 AEVMRGIRQYPG-VRYPVLTPNLQGFQHAVAAGATEIAVFGAASES 148
>sp|Q5R9E1|HMGCL_PONAB Hydroxymethylglutaryl-CoA lyase, mitochondrial OS=Pongo
abelii GN=HMGCL PE=2 SV=1
Length = 325
Score = 114 bits (285), Expect = 9e-025
Identities = 63/105 (60%), Positives = 74/105 (70%), Gaps = 2/105 (1%)
Frame = +3
Query: 594 VPKFVKIVEVGPRDGLQNEKNIVPTSVKVELIRRLVSAGLPVVEATSFVSPKWVPQLADA 773
+PK VKIVEVGPRDGLQNEKNIV T VK++LI L AGL V+E TSFVSPKWVPQ+ D
Sbjct: 29 LPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLIDMLSEAGLSVIETTSFVSPKWVPQMGDH 88
Query: 774 KNVMDAVNTLHGAARLPVLTPNLKGLK-QLSLQC*EVAIFASASE 905
V+ + G PVLTPNLKG + ++ EVAIF +ASE
Sbjct: 89 TEVLKGIQKFPG-INYPVLTPNLKGFEAAVAAGAKEVAIFGAASE 132
>sp|Q8HXZ6|HMGCL_MACFA Hydroxymethylglutaryl-CoA lyase, mitochondrial OS=Macaca
fascicularis GN=HMGCL PE=2 SV=1
Length = 325
Score = 114 bits (284), Expect = 1e-024
Identities = 63/105 (60%), Positives = 75/105 (71%), Gaps = 2/105 (1%)
Frame = +3
Query: 594 VPKFVKIVEVGPRDGLQNEKNIVPTSVKVELIRRLVSAGLPVVEATSFVSPKWVPQLADA 773
+PK VKIVEVGPRDGLQNEKNIV T VK++LI L AGL V+EATSFVSPKWVPQ+AD
Sbjct: 29 LPKQVKIVEVGPRDGLQNEKNIVSTPVKIKLIDMLSEAGLSVIEATSFVSPKWVPQMADH 88
Query: 774 KNVMDAVNTLHGAARLPVLTPNLKGLK-QLSLQC*EVAIFASASE 905
V+ + G PVL PNLKG + ++ EV+IF +ASE
Sbjct: 89 AEVLKGIQKFPGIT-YPVLIPNLKGFEAAVAAGAKEVSIFGAASE 132
>sp|P35914|HMGCL_HUMAN Hydroxymethylglutaryl-CoA lyase, mitochondrial OS=Homo
sapiens GN=HMGCL PE=1 SV=2
Length = 325
Score = 113 bits (281), Expect = 3e-024
Identities = 62/105 (59%), Positives = 73/105 (69%), Gaps = 2/105 (1%)
Frame = +3
Query: 594 VPKFVKIVEVGPRDGLQNEKNIVPTSVKVELIRRLVSAGLPVVEATSFVSPKWVPQLADA 773
+PK VKIVEVGPRDGLQNEKNIV T VK++LI L AGL V+E TSFVSPKWVPQ+ D
Sbjct: 29 LPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLIDMLSEAGLSVIETTSFVSPKWVPQMGDH 88
Query: 774 KNVMDAVNTLHGAARLPVLTPNLKGLK-QLSLQC*EVAIFASASE 905
V+ + G PVLTPNLKG + ++ EV IF +ASE
Sbjct: 89 TEVLKGIQKFPG-INYPVLTPNLKGFEAAVAAGAKEVVIFGAASE 132
>sp|A8WG57|HMGC2_DANRE Probable 3-hydroxymethyl-3-methylglutaryl-CoA lyase 2
OS=Danio rerio GN=hmgcll1 PE=2 SV=1
Length = 335
Score = 112 bits (278), Expect = 6e-024
Identities = 61/109 (55%), Positives = 77/109 (70%), Gaps = 2/109 (1%)
Frame = +3
Query: 585 LREVPKFVKIVEVGPRDGLQNEKNIVPTSVKVELIRRLVSAGLPVVEATSFVSPKWVPQL 764
L ++P +VKIVEVGPRDGLQNEK IVPT VK++LI L GLPV+EATSFVS KWV Q+
Sbjct: 36 LPKLPVYVKIVEVGPRDGLQNEKEIVPTEVKIQLIDLLSQTGLPVIEATSFVSSKWVAQM 95
Query: 765 ADAKNVMDAVNTLHGAARLPVLTPNLKGLK-QLSLQC*EVAIFASASES 908
AD V+ + R PVLTPN++G + ++ EVA+F SASE+
Sbjct: 96 ADHTAVLKGIKR-SPDVRYPVLTPNIQGFQAAVAAGANEVAVFGSASET 143
>sp|P13703|HMGCL_PSEMV Hydroxymethylglutaryl-CoA lyase OS=Pseudomonas mevalonii
GN=mvaB PE=3 SV=1
Length = 301
Score = 81 bits (199), Expect = 8e-015
Identities = 45/102 (44%), Positives = 64/102 (62%), Gaps = 2/102 (1%)
Frame = +3
Query: 606 VKIVEVGPRDGLQNEKNIVPTSVKVELIRRLVSAGLPVVEATSFVSPKWVPQLADAKNVM 785
VK+ EVGPRDGLQNE+ + + +V LI L GL +EA +FVSP+WVPQ+A + V+
Sbjct: 4 VKVFEVGPRDGLQNERQPLSVAARVGLIGELAGTGLRHIEAGAFVSPRWVPQMAGSDEVL 63
Query: 786 DAVNTLHGAARLPVLTPNLKGLKQLS-LQC*EVAIFASASES 908
+ + G + L PN +G + C EVA+FA+ASE+
Sbjct: 64 RQLPSNDGVS-YTALVPNRQGFEAAQRAGCREVAVFAAASEA 104
>sp|O34873|HMGCL_BACSU Hydroxymethylglutaryl-CoA lyase yngG OS=Bacillus subtilis
GN=yngG PE=1 SV=1
Length = 299
Score = 78 bits (190), Expect = 9e-014
Identities = 47/105 (44%), Positives = 59/105 (56%), Gaps = 2/105 (1%)
Frame = +3
Query: 597 PKFVKIVEVGPRDGLQNEKNIVPTSVKVELIRRLVSAGLPVVEATSFVSPKWVPQLADAK 776
PK V I EVGPRDGLQNE + T K+ I +L GL +E TSFV PKW+P L DA
Sbjct: 4 PKKVTIKEVGPRDGLQNEPVWIATEDKITWINQLSRTGLSYIEITSFVHPKWIPALRDAI 63
Query: 777 NVMDAVNTLHGAARLPVLTPNLKGLKQ-LSLQC*EVAIFASASES 908
+V ++ G L PN +GL+ L E +F SASE+
Sbjct: 64 DVAKGIDREKGVT-YAALVPNQRGLENALEGGINEACVFMSASET 107
Database: UniProt/SwissProt
Posted date: Sat Aug 07 14:36:18 2010
Number of letters in database: 182,829,261
Number of sequences in database: 518,415
Lambda K H
0.267 0.041 0.140
Gapped
Lambda K H
0.267 0.041 0.140
Matrix: blosum62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 26,625,186,986
Number of Sequences: 518415
Number of Extensions: 26625186986
Number of Successful Extensions: 181473514
Number of sequences better than 0.0: 0
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