BLASTX 7.6.2
Query= UN09961 /QuerySize=2294
(2293 letters)
Database: UniProt/SwissProt;
518,415 sequences; 182,829,261 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q8RWN9|OPD22_ARATH Dihydrolipoyllysine-residue acetyltransfer... 558 7e-158
sp|Q5M729|OPD23_ARATH Dihydrolipoyllysine-residue acetyltransfer... 526 4e-148
sp|P36413|ODP2_DICDI Dihydrolipoyllysine-residue acetyltransfera... 307 3e-082
sp|P08461|ODP2_RAT Dihydrolipoyllysine-residue acetyltransferase... 297 3e-079
sp|Q8BMF4|ODP2_MOUSE Dihydrolipoyllysine-residue acetyltransfera... 296 5e-079
sp|P10515|ODP2_HUMAN Dihydrolipoyllysine-residue acetyltransfera... 281 2e-074
sp|Q19749|ODP2_CAEEL Dihydrolipoyllysine-residue acetyltransfera... 260 3e-068
sp|Q1RJT3|ODP2_RICBR Dihydrolipoyllysine-residue acetyltransfera... 257 5e-067
sp|O59816|ODP2_SCHPO Dihydrolipoyllysine-residue acetyltransfera... 255 1e-066
sp|Q92HK7|ODP2_RICCN Dihydrolipoyllysine-residue acetyltransfera... 224 2e-057
sp|Q4ULG1|ODP2_RICFE Dihydrolipoyllysine-residue acetyltransfera... 219 1e-055
sp|Q9R9N3|ODP2_RHIME Dihydrolipoyllysine-residue acetyltransfera... 215 2e-054
sp|Q9ZD20|ODP2_RICPR Dihydrolipoyllysine-residue acetyltransfera... 213 4e-054
sp|Q68WK6|ODP2_RICTY Dihydrolipoyllysine-residue acetyltransfera... 211 2e-053
sp|P20285|ODP2_NEUCR Dihydrolipoyllysine-residue acetyltransfera... 196 7e-049
sp|P22439|ODPX_BOVIN Pyruvate dehydrogenase protein X component ... 173 9e-042
sp|P12695|ODP2_YEAST Dihydrolipoyllysine-residue acetyltransfera... 172 1e-041
sp|O00330|ODPX_HUMAN Pyruvate dehydrogenase protein X component,... 170 4e-041
>sp|Q8RWN9|OPD22_ARATH Dihydrolipoyllysine-residue acetyltransferase component 2
of pyruvate dehydrogenase complex, mitochondrial OS=Arabidopsis
thaliana GN=At3g13930 PE=1 SV=2
Length = 539
Score = 558 bits (1437), Expect = 7e-158
Identities = 285/303 (94%), Positives = 291/303 (96%)
Frame = +2
Query: 761 QPSSAPSEDRISASPLAKKLAEDNSVPLSSIKGTGPEGRIVKADVEEFLASRGKETTAKP 940
+PSSAPSEDRI ASPLA+KLAEDN+VPLSSIKGTGPEGRIVKADVE+FLAS KETTAKP
Sbjct: 237 KPSSAPSEDRIFASPLARKLAEDNNVPLSSIKGTGPEGRIVKADVEDFLASGSKETTAKP 296
Query: 941 PKPTDSKVPALDYVDIPHTQIRKVTASRLAFSKQTIPHYYLTVDTRVDKLMGLRSQLNSF 1120
K DSKVPALDYVDIPHTQIRKVTASRLAFSKQTIPHYYLTVDT VDK+MGLRSQLNSF
Sbjct: 297 SKQVDSKVPALDYVDIPHTQIRKVTASRLAFSKQTIPHYYLTVDTCVDKMMGLRSQLNSF 356
Query: 1121 QEASGGKRISVNDLVIKAAALALRKVPQCNSS*TDEYIRQFSNVNINVAVQTENGLYVPV 1300
QEASGGKRISVNDLVIKAAALALRKVPQCNSS TDEYIRQF NVNINVAVQTENGLYVPV
Sbjct: 357 QEASGGKRISVNDLVIKAAALALRKVPQCNSSWTDEYIRQFKNVNINVAVQTENGLYVPV 416
Query: 1301 VKDADKKGLSTIGEEVRFLAQKATENSLKPEDYEGGTFTVSNLGGPFGIKQFCAVINPPQ 1480
VKDADKKGLSTIGEEVRFLAQKA ENSLKPEDYEGGTFTVSNLGGPFGIKQFCAVINPPQ
Sbjct: 417 VKDADKKGLSTIGEEVRFLAQKAKENSLKPEDYEGGTFTVSNLGGPFGIKQFCAVINPPQ 476
Query: 1481 AAILAIGSAEKRVVTGSGPDQYNVAFYMSVTLSCDHRVIDGAIGAEWLKAFKGYIETPES 1660
AAILAIGSAEKRVV G+GPDQYNVA YMSVTLSCDHRVIDGAIGAEWLKAFKGYIETPES
Sbjct: 477 AAILAIGSAEKRVVPGTGPDQYNVASYMSVTLSCDHRVIDGAIGAEWLKAFKGYIETPES 536
Query: 1661 MLL 1669
MLL
Sbjct: 537 MLL 539
Score = 188 bits (475), Expect = 3e-046
Identities = 92/104 (88%), Positives = 99/104 (95%)
Frame = +3
Query: 450 EEEGDKVAPGEVLCEVETDKATVEMECMEEGYLARILKEEGAKAIQVGEVIAITVEEEED 629
++EGDKVAPGEVLCEVETDKATVEMECMEEG+LA+I+KEEGAK IQVGEVIAITVE+E+D
Sbjct: 133 KKEGDKVAPGEVLCEVETDKATVEMECMEEGFLAKIVKEEGAKEIQVGEVIAITVEDEDD 192
Query: 630 IQKFKDYTPSSDTSPAAPEAKPTPSPPKEEKVEKPASAPEAKTS 761
IQKFKDYTPSSDT PAAPEAKP PS PKEEKVEKPASAPEAK S
Sbjct: 193 IQKFKDYTPSSDTGPAAPEAKPAPSLPKEEKVEKPASAPEAKIS 236
Score = 177 bits (447), Expect = 5e-043
Identities = 100/180 (55%), Positives = 122/180 (67%), Gaps = 11/180 (6%)
Frame = +1
Query: 85 ASRIIIHSKKLKHVSTLLRRDHAVAVRGFSNNS--SLTARQDMLKTTRLSYSPLQRISKC 258
ASRII HSKKLKHVS LLRRDHAVAVR FSN++ SL R+D+ K RL+YS ++RISKC
Sbjct: 2 ASRIINHSKKLKHVSALLRRDHAVAVRCFSNSTHPSLVGREDIFK-ARLNYSSVERISKC 60
Query: 259 HASTVPMPSGIST--------MTGPSFSREYMSSQMRSVRGFSSGSDLPPHQEIGMPSLS 414
V M SGIST M GP +E++SSQMRSVRGFSS SDLPPHQEIGMPSLS
Sbjct: 61 GTGNVTMLSGISTTSTKLSSPMAGPKLFKEFISSQMRSVRGFSSSSDLPPHQEIGMPSLS 120
Query: 415 PTMTEGNIARWLKKKVIKSLPVKCFAKLKLTKQPLKWNAWKRVISLGY*RRRGQKQFKLG 594
PTMTEGNIARWLKK+ K P + +++ K ++ + + G K+ ++G
Sbjct: 121 PTMTEGNIARWLKKEGDKVAPGEVLCEVETDKATVEMECMEEGFLAKIVKEEGAKEIQVG 180
>sp|Q5M729|OPD23_ARATH Dihydrolipoyllysine-residue acetyltransferase component 3
of pyruvate dehydrogenase complex, mitochondrial OS=Arabidopsis
thaliana GN=At1g54220 PE=1 SV=1
Length = 539
Score = 526 bits (1353), Expect = 4e-148
Identities = 264/322 (81%), Positives = 289/322 (89%)
Frame = +2
Query: 704 PTKGREGREASQCS*SQDFQPSSAPSEDRISASPLAKKLAEDNSVPLSSIKGTGPEGRIV 883
P K + ++ S + +PS+ P+ DR+ ASPLA+KLAEDN+VPLS I+GTGPEGRIV
Sbjct: 218 PPKEEKVKQPSSPPEPKASKPSTPPTGDRVFASPLARKLAEDNNVPLSDIEGTGPEGRIV 277
Query: 884 KADVEEFLASRGKETTAKPPKPTDSKVPALDYVDIPHTQIRKVTASRLAFSKQTIPHYYL 1063
KAD++E+LAS GK TAKP K TDSK PALDYVDIPH+QIRKVTASRLAFSKQTIPHYYL
Sbjct: 278 KADIDEYLASSGKGATAKPSKSTDSKAPALDYVDIPHSQIRKVTASRLAFSKQTIPHYYL 337
Query: 1064 TVDTRVDKLMGLRSQLNSFQEASGGKRISVNDLVIKAAALALRKVPQCNSS*TDEYIRQF 1243
TVDT VDKLM LRSQLNSF+EASGGKRISVNDLV+KAAALALRKVPQCNSS TD+YIRQF
Sbjct: 338 TVDTCVDKLMALRSQLNSFKEASGGKRISVNDLVVKAAALALRKVPQCNSSWTDDYIRQF 397
Query: 1244 SNVNINVAVQTENGLYVPVVKDADKKGLSTIGEEVRFLAQKATENSLKPEDYEGGTFTVS 1423
NVNINVAVQTENGLYVPVVKDAD+KGLSTIGEEVR LAQKA ENSLKPEDYEGGTFTVS
Sbjct: 398 KNVNINVAVQTENGLYVPVVKDADRKGLSTIGEEVRLLAQKAKENSLKPEDYEGGTFTVS 457
Query: 1424 NLGGPFGIKQFCAVINPPQAAILAIGSAEKRVVTGSGPDQYNVAFYMSVTLSCDHRVIDG 1603
NLGGPFGIKQFCAV+NPPQAAILA+GSAEKRVV G+GPDQ+N A YM VTLSCDHRV+DG
Sbjct: 458 NLGGPFGIKQFCAVVNPPQAAILAVGSAEKRVVPGNGPDQFNFASYMPVTLSCDHRVVDG 517
Query: 1604 AIGAEWLKAFKGYIETPESMLL 1669
AIGAEWLKAFKGYIE P+SMLL
Sbjct: 518 AIGAEWLKAFKGYIENPKSMLL 539
>sp|P36413|ODP2_DICDI Dihydrolipoyllysine-residue acetyltransferase component of
pyruvate dehydrogenase complex, mitochondrial OS=Dictyostelium
discoideum GN=pdhC PE=1 SV=2
Length = 635
Score = 307 bits (785), Expect = 3e-082
Identities = 171/341 (50%), Positives = 225/341 (65%), Gaps = 15/341 (4%)
Frame = +2
Query: 671 SRCS*SKTNSFPTKGREGREASQCS*SQDFQPSSAPSEDRISASPLAKKLAEDNSVPLSS 850
S S S S P+ + S S S Q ++ S +RI A+P A+ A LS+
Sbjct: 302 SSSSSSSQESTPSSSSSSSQESTPSQSSS-QQTTRKSGERIFATPAARFEASSKGYDLSA 360
Query: 851 IKGTGPEGRIVKADVEEFLASR-------GKETTAKPPKPTDSKVPALDYVDIPHTQIRK 1009
I GTGP RI+KADV EF+ + ++TT KPT + + ++ DIPH+ IRK
Sbjct: 361 INGTGPNNRILKADVLEFVPQKQEVAQQQQQQTTTTTKKPT-TPTSSGEFTDIPHSNIRK 419
Query: 1010 VTASRLAFSKQTIPHYYLTVDTRVDKLMGLRSQLNSFQEASGGKRISVNDLVIKAAALAL 1189
VTA+RL SKQTIPHYYLT++ RVDKL+ LRS+LN+ +ISVND ++KA+A AL
Sbjct: 420 VTAARLTESKQTIPHYYLTMECRVDKLLKLRSELNAMNTV----KISVNDFIVKASAAAL 475
Query: 1190 RKVPQCNSS*TDEYIRQFSNVNINVAVQTENGLYVPVVKDADKKGLSTIGEEVRFLAQKA 1369
R P NS+ TD++IR++ N++INVAV T GL+ P+V+ D KGL++I V+ LA+KA
Sbjct: 476 RDNPVVNSTWTDQFIRRYHNIDINVAVNTPQGLFTPIVRGVDMKGLNSISTSVKQLAEKA 535
Query: 1370 TENSLKPEDYEGGTFTVSNLGGPFGIKQFCAVINPPQAAILAIGSAEKRVVTGSGPDQ-Y 1546
L P ++E GTFT+SNL G GIKQF AVINPPQAAILA+G+ E RVV + PD Y
Sbjct: 536 QNGKLHPSEFESGTFTISNL-GMLGIKQFAAVINPPQAAILAVGTTETRVVLSNKPDSPY 594
Query: 1547 NVAFYMSVTLSCDHRVIDGAIGAEWLKAFKGYIETPESMLL 1669
A +SVTLSCDHRVIDGA+GAEWLK+FK Y+E P ++L
Sbjct: 595 ETATILSVTLSCDHRVIDGAVGAEWLKSFKDYVENPIKLIL 635
>sp|P08461|ODP2_RAT Dihydrolipoyllysine-residue acetyltransferase component of
pyruvate dehydrogenase complex, mitochondrial OS=Rattus norvegicus
GN=Dlat PE=1 SV=3
Length = 632
Score = 297 bits (759), Expect = 3e-079
Identities = 157/306 (51%), Positives = 211/306 (68%), Gaps = 7/306 (2%)
Frame = +2
Query: 764 PSSAPS--EDRISASPLAKKLAEDNSVPLSSIKGTGPEGRIVKADVEEFLASRG--KETT 931
PS+AP+ + R+ SPLAKKLA + + L+ +KGTGPEGRI+K D++ F+ ++
Sbjct: 330 PSAAPAGPKGRVFVSPLAKKLAAEKGIDLTQVKGTGPEGRIIKKDIDSFVPTKAAPAAAA 389
Query: 932 AKPPKPTDSKVPALDYVDIPHTQIRKVTASRLAFSKQTIPHYYLTVDTRVDKLMGLRSQL 1111
A PP P + PA ++DIP + IR+V A RL SKQTIPHYYL+VD + +++ +R +L
Sbjct: 390 AAPPGPRVAPTPAGVFIDIPISNIRRVIAQRLMQSKQTIPHYYLSVDVNMGEVLLVRKEL 449
Query: 1112 NSFQEASGGKRISVNDLVIKAAALALRKVPQCNSS*TDEYIRQFSNVNINVAVQTENGLY 1291
N E G +ISVND +IKA+ALA KVP+ NSS D IRQ V+++VAV T GL
Sbjct: 450 NKMLEGKG--KISVNDFIIKASALACLKVPEANSSWMDTVIRQNHVVDVSVAVSTPAGLI 507
Query: 1292 VPVVKDADKKGLSTIGEEVRFLAQKATENSLKPEDYEGGTFTVSNLGGPFGIKQFCAVIN 1471
P+V +A KGL TI +V LA KA E L+P +++GGTFT+SNL G FGIK F A+IN
Sbjct: 508 TPIVFNAHIKGLETIASDVVSLASKAREGKLQPHEFQGGTFTISNL-GMFGIKNFSAIIN 566
Query: 1472 PPQAAILAIGSAEKRVVTGSGPDQYNVAFYMSVTLSCDHRVIDGAIGAEWLKAFKGYIET 1651
PPQA ILAIG++E +++ ++VA MSVTLSCDHRV+DGA+GA+WL FK Y+E
Sbjct: 567 PPQACILAIGASEDKLIPADNEKGFDVASVMSVTLSCDHRVVDGAVGAQWLAEFKKYLEK 626
Query: 1652 PESMLL 1669
P +MLL
Sbjct: 627 PVTMLL 632
>sp|Q8BMF4|ODP2_MOUSE Dihydrolipoyllysine-residue acetyltransferase component of
pyruvate dehydrogenase complex, mitochondrial OS=Mus musculus GN=Dlat
PE=1 SV=2
Length = 642
Score = 296 bits (757), Expect = 5e-079
Identities = 158/307 (51%), Positives = 210/307 (68%), Gaps = 8/307 (2%)
Frame = +2
Query: 764 PSSAPS--EDRISASPLAKKLAEDNSVPLSSIKGTGPEGRIVKADVEEFLASRGKETTA- 934
PS+AP+ + R+ SPLAKKLA + + L+ +KGTGPEGRI+K D++ F+ S+ A
Sbjct: 339 PSAAPAGPKGRVFVSPLAKKLAAEKGIDLTQVKGTGPEGRIIKKDIDSFVPSKAAPAAAA 398
Query: 935 --KPPKPTDSKVPALDYVDIPHTQIRKVTASRLAFSKQTIPHYYLTVDTRVDKLMGLRSQ 1108
PP P + PA + DIP + IR+V A RL SKQTIPHYYL+VD + +++ +R +
Sbjct: 399 AMAPPGPRVAPAPAGVFTDIPISNIRRVIAQRLMQSKQTIPHYYLSVDVNMGEVLLVRKE 458
Query: 1109 LNSFQEASGGKRISVNDLVIKAAALALRKVPQCNSS*TDEYIRQFSNVNINVAVQTENGL 1288
LN E G +ISVND +IKA+ALA KVP+ NSS D IRQ V+++VAV T GL
Sbjct: 459 LNKMLEGKG--KISVNDFIIKASALACLKVPEANSSWMDTVIRQNHVVDVSVAVSTPAGL 516
Query: 1289 YVPVVKDADKKGLSTIGEEVRFLAQKATENSLKPEDYEGGTFTVSNLGGPFGIKQFCAVI 1468
P+V +A KGL TI +V LA KA E L+P +++GGTFT+SNL G FGIK F A+I
Sbjct: 517 ITPIVFNAHIKGLETIASDVVSLASKAREGKLQPHEFQGGTFTISNL-GMFGIKNFSAII 575
Query: 1469 NPPQAAILAIGSAEKRVVTGSGPDQYNVAFYMSVTLSCDHRVIDGAIGAEWLKAFKGYIE 1648
NPPQA ILAIG++E +++ ++VA MSVTLSCDHRV+DGA+GA+WL FK Y+E
Sbjct: 576 NPPQACILAIGASEDKLIPADNEKGFDVASVMSVTLSCDHRVVDGAVGAQWLAEFKKYLE 635
Query: 1649 TPESMLL 1669
P +MLL
Sbjct: 636 KPITMLL 642
>sp|P10515|ODP2_HUMAN Dihydrolipoyllysine-residue acetyltransferase component of
pyruvate dehydrogenase complex, mitochondrial OS=Homo sapiens GN=DLAT
PE=1 SV=3
Length = 647
Score = 281 bits (718), Expect = 2e-074
Identities = 150/302 (49%), Positives = 202/302 (66%), Gaps = 6/302 (1%)
Frame = +2
Query: 773 APSEDRISASPLAKKLAEDNSVPLSSIKGTGPEGRIVKADVEEFLASR---GKETTAKPP 943
A + R+ SPLAKKLA + + L+ +KGTGP+GRI K D++ F+ S+ P
Sbjct: 349 AGPKGRVFVSPLAKKLAVEKGIDLTQVKGTGPDGRITKKDIDSFVPSKVAPAPAAVVPPT 408
Query: 944 KPTDSKVPALDYVDIPHTQIRKVTASRLAFSKQTIPHYYLTVDTRVDKLMGLRSQLNSFQ 1123
P + VP + DIP + IR+V A RL SKQTIPHYYL++D + +++ +R +LN
Sbjct: 409 GPGMAPVPTGVFTDIPISNIRRVIAQRLMQSKQTIPHYYLSIDVNMGEVLLVRKELNKIL 468
Query: 1124 EASGGKRISVNDLVIKAAALALRKVPQCNSS*TDEYIRQFSNVNINVAVQTENGLYVPVV 1303
E G +ISVND +IKA+ALA KVP+ NSS D IRQ V+++VAV T GL P+V
Sbjct: 469 E--GRSKISVNDFIIKASALACLKVPEANSSWMDTVIRQNHVVDVSVAVSTPAGLITPIV 526
Query: 1304 KDADKKGLSTIGEEVRFLAQKATENSLKPEDYEGGTFTVSNLGGPFGIKQFCAVINPPQA 1483
+A KG+ TI +V LA KA E L+P +++GGTFT+SNL G FGIK F A+INPPQA
Sbjct: 527 FNAHIKGVETIANDVVSLATKAREGKLQPHEFQGGTFTISNL-GMFGIKNFSAIINPPQA 585
Query: 1484 AILAIGSAEKRVVTGSGPDQYNVAFYMSVTLSCDHRVIDGAIGAEWLKAFKGYIETPESM 1663
ILAIG++E ++V ++VA MSVTLSCDHRV+DGA+GA+WL F+ Y+E P +M
Sbjct: 586 CILAIGASEDKLVPADNEKGFDVASMMSVTLSCDHRVVDGAVGAQWLAEFRKYLEKPITM 645
Query: 1664 LL 1669
LL
Sbjct: 646 LL 647
>sp|Q19749|ODP2_CAEEL Dihydrolipoyllysine-residue acetyltransferase component of
pyruvate dehydrogenase complex, mitochondrial OS=Caenorhabditis elegans
GN=F23B12.5 PE=1 SV=1
Length = 507
Score = 260 bits (664), Expect = 3e-068
Identities = 143/309 (46%), Positives = 197/309 (63%), Gaps = 15/309 (4%)
Frame = +2
Query: 764 PSSAP----SEDRISASPLAKKLAEDNSVPLSSIKGTGPEGRIVKADVEEFLASRGKETT 931
P SAP S R+SASP AKKLA +N + LS + G+GP GRI+ +D+ + A TT
Sbjct: 207 PKSAPIPHSSSGRVSASPFAKKLAAENGLDLSGVSGSGPGGRILASDLSQAPAKGATSTT 266
Query: 932 AKPPKPTDSKVPALDYVDIPHTQIRKVTASRLAFSKQTIPHYYLTVDTRVDKLMGLRSQL 1111
+ V DY DIP + +RK A RL SK TIPHYYLT + ++D L+ +R +L
Sbjct: 267 TQ-------AVSGQDYTDIPLSNMRKTIAKRLTESKSTIPHYYLTSEIQLDTLLQVREKL 319
Query: 1112 NSF--QEASG-GKRISVNDLVIKAAALALRKVPQCNSS*TDEYIRQFSNVNINVAVQTEN 1282
N + SG +IS+ND +IKA+ALA ++VP+ NS D +IR+ +V+++VAV T
Sbjct: 320 NGLLAKGTSGQATKISINDFIIKASALACQRVPEANSYWMDSFIRENHHVDVSVAVSTPA 379
Query: 1283 GLYVPVVKDADKKGLSTIGEEVRFLAQKATENSLKPEDYEGGTFTVSNLGGPFGIKQFCA 1462
GL P++ +A KGL+TI E+ LAQ+A E L+P +++GGTFTVSNLG + F A
Sbjct: 380 GLITPIIFNAHAKGLATIASEIVELAQRAREGKLQPHEFQGGTFTVSNLGMFGSVSDFTA 439
Query: 1463 VINPPQAAILAIGSAEKRVVTGSGPDQYNVAFYMSVTLSCDHRVIDGAIGAEWLKAFKGY 1642
+INPPQ+ ILAIG A ++V + Y M VTLSCDHR +DGA+GA WL+ FK +
Sbjct: 440 IINPPQSCILAIGGASDKLVPDEA-EGYKKIKTMKVTLSCDHRTVDGAVGAVWLRHFKEF 498
Query: 1643 IETPESMLL 1669
+E P +MLL
Sbjct: 499 LEKPHTMLL 507
>sp|Q1RJT3|ODP2_RICBR Dihydrolipoyllysine-residue acetyltransferase component of
pyruvate dehydrogenase complex OS=Rickettsia bellii (strain RML369-C)
GN=pdhC PE=3 SV=1
Length = 418
Score = 257 bits (654), Expect = 5e-067
Identities = 138/309 (44%), Positives = 205/309 (66%), Gaps = 15/309 (4%)
Frame = +2
Query: 752 QDFQPSSAPSEDRISASPLAKKLAEDNSVPLSSIKGTGPEGRIVKADVEEFLASRGKETT 931
++ +S + ++ ASPLAK+LA+ +V + IKG+GP GRI+K DV L+ +G
Sbjct: 119 ENITTASDQNNIKVFASPLAKRLAKIQNVRIEEIKGSGPHGRIIKQDV---LSHKGGS-- 173
Query: 932 AKPPKPTDSKVPAL---DYVDIPHTQIRKVTASRLAFSKQTIPHYYLTVDTRVDKLMGLR 1102
K +K+ + +Y P+ IRK+ A RL SKQT+PH+YL+++ VDKL+ +R
Sbjct: 174 ----KALSNKIVSRNPEEYRLAPNNNIRKIIAKRLLESKQTVPHFYLSIECNVDKLLDIR 229
Query: 1103 SQLNSFQEASGGKRISVNDLVIKAAALALRKVPQCNSS*TDEYIRQFSNVNINVAVQTEN 1282
+N +ISVND +I A A AL++VP N+S D+ IR ++NV+I+VAV EN
Sbjct: 230 EDINKSFGDDKSAKISVNDFIILAVAKALQEVPNANASWGDDAIRYYNNVDISVAVAIEN 289
Query: 1283 GLYVPVVKDADKKGLSTIGEEVRFLAQKATENSLKPEDYEGGTFTVSNLGGPFGIKQFCA 1462
GL P++++AD+K + + E++ L +KA EN L PE+++GG FT+SNL G +GIK F A
Sbjct: 290 GLVTPIIRNADQKNIVDLSSEMKGLIKKARENKLTPEEFQGGGFTISNL-GMYGIKNFNA 348
Query: 1463 VINPPQAAILAIGSAEKRVVTGSGPDQYNVAFYMSVTLSCDHRVIDGAIGAEWLKAFKGY 1642
+INPPQ+ I+ +GS+ KR + + DQ ++A M VTLS DHRV+DGA+GAE+L AFK +
Sbjct: 349 IINPPQSCIMGVGSSSKRAIVKN--DQISIATIMDVTLSADHRVVDGAVGAEFLAAFKRF 406
Query: 1643 IETPESMLL 1669
IE+P MLL
Sbjct: 407 IESPALMLL 415
>sp|O59816|ODP2_SCHPO Dihydrolipoyllysine-residue acetyltransferase component of
pyruvate dehydrogenase complex, mitochondrial OS=Schizosaccharomyces
pombe GN=SPCC794.07 PE=2 SV=1
Length = 483
Score = 255 bits (650), Expect = 1e-066
Identities = 146/332 (43%), Positives = 204/332 (61%), Gaps = 16/332 (4%)
Frame = +2
Query: 698 SFPTKGREGREASQCS*SQDFQPSSAPSEDRISASPLAKKLAEDNSVPLSSIKGTGPEGR 877
S P+ ++ +E S S S DR+ ASPLA+KLAE+ + LS I+G+GP GR
Sbjct: 160 SAPSSEKQSKETSSPS-----NVSGEERGDRVFASPLARKLAEEKDLDLSQIRGSGPNGR 214
Query: 878 IVKADVEEF----LASRGKETTAKPPKPTDSKVPAL---DYVDIPHTQIRKVTASRLAFS 1036
I+K D+E F E AK P S A DY D+P + +RK+ ASRLA S
Sbjct: 215 IIKVDIENFKPVVAPKPSNEAAAKATTPAASAADAAAPGDYEDLPLSNMRKIIASRLAES 274
Query: 1037 KQTIPHYYLTVDTRVDKLMGLRSQLNSFQEASGGKRISVNDLVIKAAALALRKVPQCNSS 1216
K PHYY+TV ++K++ LR+ LN+ A G ++SVNDLVIKA ALR+VP+ N++
Sbjct: 275 KNMNPHYYVTVSVNMEKIIRLRAALNAM--ADGRYKLSVNDLVIKATTAALRQVPEVNAA 332
Query: 1217 *TDEYIRQFSNVNINVAVQTENGLYVPVVKDADKKGLSTIGEEVRFLAQKATENSLKPED 1396
++IRQ+ NV+I++AV T +GL PV+++ GL+ I + Q+A N LKPE+
Sbjct: 333 WMGDFIRQYKNVDISMAVATPSGLITPVIRNTHALGLAEISTLAKDYGQRARNNKLKPEE 392
Query: 1397 YEGGTFTVSNLGGPFGIKQFCAVINPPQAAILAIGSAEKRVVTGSGPDQ-YNVAFYMSVT 1573
Y+GGTFT+SNL G F + QF A+INPPQA ILA+G+ VV S ++ + VA M T
Sbjct: 393 YQGGTFTISNL-GMFPVDQFTAIINPPQACILAVGTTVDTVVPDSTSEKGFKVAPIMKCT 451
Query: 1574 LSCDHRVIDGAIGAEWLKAFKGYIETPESMLL 1669
LS DHRV+DGA+ A + A K +E P ++L
Sbjct: 452 LSSDHRVVDGAMAARFTTALKKILENPLEIML 483
>sp|Q92HK7|ODP2_RICCN Dihydrolipoyllysine-residue acetyltransferase component of
pyruvate dehydrogenase complex OS=Rickettsia conorii GN=pdhC PE=3 SV=1
Length = 412
Score = 224 bits (570), Expect = 2e-057
Identities = 111/230 (48%), Positives = 162/230 (70%), Gaps = 3/230 (1%)
Frame = +2
Query: 974 DYVDIPHTQIRKVTASRLAFSKQTIPHYYLTVDTRVDKLMGLRSQLNSFQEASGGKRISV 1153
+Y +P+ IRK+ A RL SKQT+PH+YL+++ VDKL+ +R +N F RISV
Sbjct: 184 EYRLVPNNNIRKIIAKRLLESKQTVPHFYLSIECNVDKLLDIREDINKFFSEDKSTRISV 243
Query: 1154 NDLVIKAAALALRKVPQCNSS*TDEYIRQFSNVNINVAVQTENGLYVPVVKDADKKGLST 1333
ND +I A A AL++VP N+S ++ IR ++NV+I+VAV ENGL P+VK+A++K +
Sbjct: 244 NDFIILAVAKALQEVPNANASWGEDAIRYYNNVDISVAVAIENGLVTPIVKNANQKNILE 303
Query: 1334 IGEEVRFLAQKATENSLKPEDYEGGTFTVSNLGGPFGIKQFCAVINPPQAAILAIGSAEK 1513
+ E++ L +KA +N L PE+++GG FT+SNL G +GIK F A+INPPQ+ I+ +G++ K
Sbjct: 304 LSREMKALIKKAKDNKLTPEEFQGGGFTISNL-GMYGIKNFNAIINPPQSCIMGVGASAK 362
Query: 1514 RVVTGSGPDQYNVAFYMSVTLSCDHRVIDGAIGAEWLKAFKGYIETPESM 1663
R + + DQ +A M VTLS DHRV+DGA+GAE+L AFK +IE+P M
Sbjct: 363 RAIVKN--DQITIATIMDVTLSADHRVVDGAVGAEFLVAFKKFIESPVLM 410
>sp|Q4ULG1|ODP2_RICFE Dihydrolipoyllysine-residue acetyltransferase component of
pyruvate dehydrogenase complex OS=Rickettsia felis GN=pdhC PE=3 SV=1
Length = 412
Score = 219 bits (556), Expect = 1e-055
Identities = 109/230 (47%), Positives = 160/230 (69%), Gaps = 3/230 (1%)
Frame = +2
Query: 974 DYVDIPHTQIRKVTASRLAFSKQTIPHYYLTVDTRVDKLMGLRSQLNSFQEASGGKRISV 1153
+Y +P+ IRK+ A RL SKQT+PH+YL+++ VDKL+ +R +N RISV
Sbjct: 184 EYRLVPNNNIRKIIAKRLLESKQTVPHFYLSIECNVDKLLDIREDINKSFSEDKSTRISV 243
Query: 1154 NDLVIKAAALALRKVPQCNSS*TDEYIRQFSNVNINVAVQTENGLYVPVVKDADKKGLST 1333
ND +I A A AL+++P N+S ++ IR +NV+I+VAV ENGL P+VK+A++K +
Sbjct: 244 NDFIILAVAKALQELPNANASWGEDAIRYHNNVDISVAVAIENGLVTPIVKNANQKNIIE 303
Query: 1334 IGEEVRFLAQKATENSLKPEDYEGGTFTVSNLGGPFGIKQFCAVINPPQAAILAIGSAEK 1513
+ E++ L +KA +N L PE+++GG FT+SNL G +GIK F A+INPPQ+ I+ +G++ K
Sbjct: 304 LSREMKELIKKAKDNKLTPEEFQGGGFTISNL-GMYGIKNFNAIINPPQSCIMGVGASAK 362
Query: 1514 RVVTGSGPDQYNVAFYMSVTLSCDHRVIDGAIGAEWLKAFKGYIETPESM 1663
R + + DQ +A M VTLS DHRV+DGA+GAE+L AFK +IE+P M
Sbjct: 363 RAIVKN--DQVTIATIMDVTLSADHRVVDGAVGAEFLAAFKKFIESPALM 410
>sp|Q9R9N3|ODP2_RHIME Dihydrolipoyllysine-residue acetyltransferase component of
pyruvate dehydrogenase complex OS=Rhizobium meliloti GN=pdhC PE=3 SV=1
Length = 447
Score = 215 bits (545), Expect = 2e-054
Identities = 116/232 (50%), Positives = 153/232 (65%), Gaps = 6/232 (2%)
Frame = +2
Query: 977 YVDIPHTQIRKVTASRLAFSKQTIPHYYLTVDTRVDKLMGLRSQLNSFQEASGGK---RI 1147
Y +PH +RK A RL SKQTIPH+Y++VD +D LM LR+QLN+ GK ++
Sbjct: 217 YELVPHDGMRKTIAKRLVESKQTIPHFYVSVDCELDALMALRAQLNAAAPEKDGKPVYKL 276
Query: 1148 SVNDLVIKAAALALRKVPQCNSS*TDEYIRQFSNVNINVAVQTENGLYVPVVKDADKKGL 1327
SVND+VIKA ALALR VP N S TD+ + + + ++ VAV GL P+V+ A+ K L
Sbjct: 277 SVNDMVIKALALALRDVPDANVSWTDQNMVKHKHADVGVAVSIPGGLITPIVRQAELKSL 336
Query: 1328 STIGEEVRFLAQKATENSLKPEDYEGGTFTVSNLGGPFGIKQFCAVINPPQAAILAIGSA 1507
S I E++ L ++A E LKPE+Y+GGT VSN+ G G+K F AV+NPP A ILA+G+
Sbjct: 337 SAISNEMKDLGKRAKERKLKPEEYQGGTTAVSNM-GMMGVKDFAAVVNPPHATILAVGAG 395
Query: 1508 EKRVVTGSGPDQYNVAFYMSVTLSCDHRVIDGAIGAEWLKAFKGYIETPESM 1663
E RVV + + +A M+VTLS DHR +DGA+GAE L AFK YIE P M
Sbjct: 396 EDRVVVRN--KEMVIANVMTVTLSTDHRCVDGALGAELLAAFKRYIENPMGM 445
>sp|Q9ZD20|ODP2_RICPR Dihydrolipoyllysine-residue acetyltransferase component of
pyruvate dehydrogenase complex OS=Rickettsia prowazekii GN=pdhC PE=3
SV=1
Length = 408
Score = 213 bits (542), Expect = 4e-054
Identities = 107/230 (46%), Positives = 158/230 (68%), Gaps = 3/230 (1%)
Frame = +2
Query: 974 DYVDIPHTQIRKVTASRLAFSKQTIPHYYLTVDTRVDKLMGLRSQLNSFQEASGGKRISV 1153
+Y +P+ IRK+ A RL SKQT+PH+YL+++ VDKL+ +R +N +ISV
Sbjct: 180 EYRSVPNNNIRKIIAKRLLESKQTVPHFYLSIECNVDKLLDVREDINKSFSEDKVTKISV 239
Query: 1154 NDLVIKAAALALRKVPQCNSS*TDEYIRQFSNVNINVAVQTENGLYVPVVKDADKKGLST 1333
ND +I A A AL++VP N+S +++ IR ++NV+I+VAV ENG+ P+VKDA+KK +
Sbjct: 240 NDFIILAVAKALQEVPNANASWSEDAIRYYNNVDISVAVAIENGIVTPIVKDANKKNIIE 299
Query: 1334 IGEEVRFLAQKATENSLKPEDYEGGTFTVSNLGGPFGIKQFCAVINPPQAAILAIGSAEK 1513
+ E++ L +KA +N L P +++GG FT+SNL G +GIK F A+IN PQ+ I+ +G++ K
Sbjct: 300 LSREMKTLIKKAKDNKLTPIEFQGGGFTISNL-GMYGIKNFNAIINTPQSCIMGVGASTK 358
Query: 1514 RVVTGSGPDQYNVAFYMSVTLSCDHRVIDGAIGAEWLKAFKGYIETPESM 1663
R + + DQ +A M VTLS DHRVIDGA+ AE+L +FK +IE P M
Sbjct: 359 RAIVKN--DQIIIATIMDVTLSADHRVIDGAVSAEFLASFKRFIENPVLM 406
>sp|Q68WK6|ODP2_RICTY Dihydrolipoyllysine-residue acetyltransferase component of
pyruvate dehydrogenase complex OS=Rickettsia typhi GN=pdhC PE=3 SV=1
Length = 404
Score = 211 bits (537), Expect = 2e-053
Identities = 105/230 (45%), Positives = 157/230 (68%), Gaps = 3/230 (1%)
Frame = +2
Query: 974 DYVDIPHTQIRKVTASRLAFSKQTIPHYYLTVDTRVDKLMGLRSQLNSFQEASGGKRISV 1153
+Y +P+ IR++ A RL SKQT+PH+YL+++ VDKL+ +R +N +ISV
Sbjct: 176 EYRSVPNNNIRQIIAKRLLESKQTVPHFYLSIECNVDKLLDIREDINKSFSEDKLTKISV 235
Query: 1154 NDLVIKAAALALRKVPQCNSS*TDEYIRQFSNVNINVAVQTENGLYVPVVKDADKKGLST 1333
ND +I A A AL++VP N+S ++ IR ++NV+I+VAV ENG+ P++KDA+KK +
Sbjct: 236 NDFIILAVAKALQEVPNANASWAEDAIRYYNNVDISVAVAIENGIVTPIIKDANKKNIIE 295
Query: 1334 IGEEVRFLAQKATENSLKPEDYEGGTFTVSNLGGPFGIKQFCAVINPPQAAILAIGSAEK 1513
+ E++ L +KA +N L P +++GG FT+SNL G +GIK F A+IN PQ+ I+ +G++ K
Sbjct: 296 LSHEMKILIKKAKDNKLTPVEFQGGGFTISNL-GMYGIKNFNAIINTPQSCIMGVGASTK 354
Query: 1514 RVVTGSGPDQYNVAFYMSVTLSCDHRVIDGAIGAEWLKAFKGYIETPESM 1663
R + + DQ +A M VTLS DHRVIDGA+ AE+L +FK +IE P M
Sbjct: 355 RAIVKN--DQIIIATIMDVTLSADHRVIDGAVSAEFLASFKRFIEHPVLM 402
>sp|P20285|ODP2_NEUCR Dihydrolipoyllysine-residue acetyltransferase component of
pyruvate dehydrogenase complex, mitochondrial OS=Neurospora crassa
GN=mrp-3 PE=1 SV=2
Length = 458
Score = 196 bits (497), Expect = 7e-049
Identities = 119/310 (38%), Positives = 175/310 (56%), Gaps = 12/310 (3%)
Frame = +2
Query: 764 PSSAPSEDRISASPLAKKLAEDNSVPLSSIKGTGPEGRIVKADVEEFLASRGKETTAKPP 943
P+ AP + S + + E L + K E I +V+ + G + T +
Sbjct: 153 PTPAPEPENTSFTGRFQTALEREPNALPAAKRLAREKGIDLRNVKG--SGPGGKITEEDV 210
Query: 944 KPTDSKVPALD-----YVDIPHTQIRKVTASRLAFSKQTIPHYYLTVDTRVDKLMGLRSQ 1108
K + PA Y D+P + +RK A+RL S PH++++ + V KL+ LR
Sbjct: 211 KKALASAPAAGAAAAAYTDVPISGMRKTIAARLKESVTENPHFFVSTNLSVSKLLKLRQA 270
Query: 1109 LNSFQEASGGKRISVNDLVIKAAALALRKVPQCNSS*TDEYIRQFSNVNINVAVQTENGL 1288
LNS A G ++SVND +IKA +A ++VP NSS D IRQF V+++VAV T NGL
Sbjct: 271 LNS--SADGRYKLSVNDFLIKAMGIASKRVPTVNSSWRDGVIRQFETVDVSVAVATPNGL 328
Query: 1289 YVPVVKDADKKGLSTIGEEVRFLAQKATENSLKPEDYEGGTFTVSNLGGPFGIKQFCAVI 1468
P+VK + KGL +I V+ LA+KA + LKPE+Y+GG+ ++SN+G ++ F A+I
Sbjct: 329 ITPIVKGVEGKGLESISAAVKELAKKARDGKLKPEEYQGGSISISNMGMNPAVQSFTAII 388
Query: 1469 NPPQAAILAIGSAEKRVVTGSGPDQYNVAFY---MSVTLSCDHRVIDGAIGAEWLKAFKG 1639
NPPQAAILA+G+ +K V D + + VT S DH+V+DGA+GAEW++ K
Sbjct: 389 NPPQAAILAVGAPQKVAVPVENEDGTTGVSWDEQIIVTASFDHKVVDGAVGAEWIRELKK 448
Query: 1640 YIETPESMLL 1669
IE P +LL
Sbjct: 449 VIENPLELLL 458
>sp|P22439|ODPX_BOVIN Pyruvate dehydrogenase protein X component OS=Bos taurus
GN=PDHX PE=1 SV=3
Length = 501
Score = 173 bits (436), Expect = 9e-042
Identities = 96/229 (41%), Positives = 139/229 (60%), Gaps = 9/229 (3%)
Frame = +2
Query: 977 YVDIPHTQIRKVTASRLAFSKQTIPHYYLTVDTRVDKLMGLRSQLNSFQEASGGKRISVN 1156
+ +IP + IR+V A RL SK TIPH Y T D + ++ R L ++SVN
Sbjct: 275 FTEIPASNIRRVIAKRLTESKSTIPHAYATTDCDLGAVLTARQNL-----VRDDIKVSVN 329
Query: 1157 DLVIKAAALALRKVPQCNSS*TDEYIRQFSNVNINVAVQTENGLYVPVVKDADKKGLSTI 1336
D +IKAAA+ L+++P N+S E +Q +++I+VAV T+ GL PV+KDA KGL I
Sbjct: 330 DFIIKAAAVTLKQMPNVNASWDGEGAKQLPSIDISVAVATDRGLITPVIKDAAAKGLQEI 389
Query: 1337 GEEVRFLAQKATENSLKPEDYEGGTFTVSNLGGPFGIKQFCAVINPPQAAILAIGSAE-- 1510
+ V+ L++KA + L PE+Y+GG+F++SNL G FGI +F AVINPPQA ILA+G
Sbjct: 390 ADSVKALSKKARDGKLLPEEYQGGSFSISNL-GMFGIDEFTAVINPPQACILAVGRFRPV 448
Query: 1511 -KRVVTGSGPDQYNVAFYMSVTLSCDHRVIDGAIGAEWLKAFKGYIETP 1654
K G Q ++VT+S D RV+D + +L++FK +E P
Sbjct: 449 LKLTQDEEGNAQLQQRQLITVTMSSDSRVVDDELATRFLESFKANLENP 497
>sp|P12695|ODP2_YEAST Dihydrolipoyllysine-residue acetyltransferase component of
pyruvate dehydrogenase complex, mitochondrial OS=Saccharomyces
cerevisiae GN=PDA2 PE=1 SV=1
Length = 482
Score = 172 bits (434), Expect = 1e-041
Identities = 95/257 (36%), Positives = 150/257 (58%), Gaps = 9/257 (3%)
Frame = +2
Query: 908 ASRGKETTAKPPKPTDSKVPALDYVDIPHTQIRKVTASRLAFSKQTIPHYYLTVDTRVDK 1087
A+ T P P+ + Y D+P + +R + RL S Q IP Y ++ + K
Sbjct: 232 AATSSTTAGSAPSPSST----ASYEDVPISTMRSIIGERLLQSTQGIPSYIVSSKISISK 287
Query: 1088 LMGLRSQLNSFQEASGGKRISVNDLVIKAAALALRKVPQCNS--S*TDEYIRQFSNVNIN 1261
L+ LR LN+ A+ ++S+NDL++KA +A ++VP N+ + IR+F NV+++
Sbjct: 288 LLKLRQSLNA--TANDKYKLSINDLLVKAITVAAKRVPDANAYWLPNENVIRKFKNVDVS 345
Query: 1262 VAVQTENGLYVPVVKDADKKGLSTIGEEVRFLAQKATENSLKPEDYEGGTFTVSNLGGPF 1441
VAV T GL P+VK+ + KGLS I E++ L ++A N L PE+++GGT +SN+G
Sbjct: 346 VAVATPTGLLTPIVKNCEAKGLSQISNEIKELVKRARINKLAPEEFQGGTICISNMGMNN 405
Query: 1442 GIKQFCAVINPPQAAILAIGSAEKRVVTGSGPDQ-YNVAFYMSVTLSCDHRVIDGAIGAE 1618
+ F ++INPPQ+ ILAI + E+ V + + ++ +++T + DHR IDGA GAE
Sbjct: 406 AVNMFTSIINPPQSTILAIATVERVAVEDAAAENGFSFDNQVTITGTFDHRTIDGAKGAE 465
Query: 1619 WLKAFKGYIETPESMLL 1669
++K K IE P MLL
Sbjct: 466 FMKELKTVIENPLEMLL 482
>sp|O00330|ODPX_HUMAN Pyruvate dehydrogenase protein X component, mitochondrial
OS=Homo sapiens GN=PDHX PE=1 SV=3
Length = 501
Score = 170 bits (430), Expect = 4e-041
Identities = 106/291 (36%), Positives = 158/291 (54%), Gaps = 20/291 (6%)
Frame = +2
Query: 824 EDNSVPLSSIKGTG--PEGRIVKADVEEFLASRGKETTAKPPKPTDSKVPAL-------- 973
+++++ L +K TG E R A A + TA P P P
Sbjct: 213 KEDALKLVQLKQTGKITESRPTPAPTATPTAPSPLQATAGPSYPRPVIPPVSTPGQPNAV 272
Query: 974 -DYVDIPHTQIRKVTASRLAFSKQTIPHYYLTVDTRVDKLMGLRSQLNSFQEASGGKRIS 1150
+ +IP + IR+V A RL SK T+PH Y T D + ++ +R L ++S
Sbjct: 273 GTFTEIPASNIRRVIAKRLTESKSTVPHAYATADCDLGAVLKVRQDL-----VKDDIKVS 327
Query: 1151 VNDLVIKAAALALRKVPQCNSS*TDEYIRQFSNVNINVAVQTENGLYVPVVKDADKKGLS 1330
VND +IKAAA+ L+++P N S E +Q ++I+VAV T+ GL P++KDA KG+
Sbjct: 328 VNDFIIKAAAVTLKQMPDVNVSWDGEGPKQLPFIDISVAVATDKGLLTPIIKDAAAKGIQ 387
Query: 1331 TIGEEVRFLAQKATENSLKPEDYEGGTFTVSNLGGPFGIKQFCAVINPPQAAILAIGSAE 1510
I + V+ L++KA + L PE+Y+GG+F++SNL G FGI +F AVINPPQA ILA+G
Sbjct: 388 EIADSVKALSKKARDGKLLPEEYQGGSFSISNL-GMFGIDEFTAVINPPQACILAVGRFR 446
Query: 1511 ---KRVVTGSGPDQYNVAFYMSVTLSCDHRVIDGAIGAEWLKAFKGYIETP 1654
K G + ++VT+S D RV+D + +LK+FK +E P
Sbjct: 447 PVLKLTEDEEGNAKLQQRQLITVTMSSDSRVVDDELATRFLKSFKANLENP 497
Database: UniProt/SwissProt
Posted date: Sat Aug 07 14:36:18 2010
Number of letters in database: 182,829,261
Number of sequences in database: 518,415
Lambda K H
0.267 0.041 0.140
Gapped
Lambda K H
0.267 0.041 0.140
Matrix: blosum62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 41,366,676,449
Number of Sequences: 518415
Number of Extensions: 41366676449
Number of Successful Extensions: 294470065
Number of sequences better than 0.0: 0
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