BLASTX 7.6.2
Query= UN23371 /QuerySize=1326
(1325 letters)
Database: UniProt/SwissProt;
518,415 sequences; 182,829,261 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q9Y394|DHRS7_HUMAN Dehydrogenase/reductase SDR family member ... 203 2e-051
sp|Q9Y140|DHRS7_DROME Dehydrogenase/reductase SDR family protein... 145 1e-033
sp|Q7Q732|DHRS7_ANOGA Dehydrogenase/reductase SDR family protein... 127 2e-028
sp|Q566S6|DRS7B_DANRE Dehydrogenase/reductase SDR family member ... 121 1e-026
sp|Q5R6U1|DRS7B_PONAB Dehydrogenase/reductase SDR family member ... 121 2e-026
sp|Q6IAN0|DRS7B_HUMAN Dehydrogenase/reductase SDR family member ... 120 3e-026
sp|Q3T0R4|DRS7B_BOVIN Dehydrogenase/reductase SDR family member ... 119 8e-026
sp|Q0IH28|DRS7B_XENLA Dehydrogenase/reductase SDR family member ... 115 1e-024
sp|Q99J47|DRS7B_MOUSE Dehydrogenase/reductase SDR family member ... 113 3e-024
sp|Q0VFE7|DRS7B_XENTR Dehydrogenase/reductase SDR family member ... 109 8e-023
sp|Q5RJY4|DRS7B_RAT Dehydrogenase/reductase SDR family member 7B... 105 1e-021
sp|Q9BTZ2|DHRS4_HUMAN Dehydrogenase/reductase SDR family member ... 102 7e-021
sp|Q5RCF8|DHRS4_PONAB Dehydrogenase/reductase SDR family member ... 102 7e-021
sp|P54554|YQJQ_BACSU Uncharacterized oxidoreductase yqjQ OS=Baci... 97 3e-019
sp|Q5BL28|DS7CB_DANRE Dehydrogenase/reductase SDR family member ... 96 4e-019
sp|Q6PKH6|DR4L2_HUMAN Dehydrogenase/reductase SDR family member ... 95 9e-019
sp|A9UM79|DRS7C_XENTR Dehydrogenase/reductase SDR family member ... 94 2e-018
sp|A8E5C5|DS7CA_DANRE Dehydrogenase/reductase SDR family member ... 91 1e-017
sp|Q9X248|FABG_THEMA 3-oxoacyl-[acyl-carrier-protein] reductase ... 91 1e-017
sp|Q8CHS7|DRS7C_MOUSE Dehydrogenase/reductase SDR family member ... 90 3e-017
>sp|Q9Y394|DHRS7_HUMAN Dehydrogenase/reductase SDR family member 7 OS=Homo
sapiens GN=DHRS7 PE=1 SV=1
Length = 339
Score = 203 bits (516), Expect = 2e-051
Identities = 129/319 (40%), Positives = 182/319 (57%), Gaps = 16/319 (5%)
Frame = +3
Query: 60 KMLTLLFSSLGLLLLLGLLLKFAFADGDLTLISKKHVKRE---AIEGKVVWITGASRGIG 230
++L L LLLLL LL+F ADGDLTL+ + R + VVW+TGAS GIG
Sbjct: 4 ELLLWLLVLCALLLLLVQLLRFLRADGDLTLLWAEWQGRRPEWELTDMVVWVTGASSGIG 63
Query: 231 EVLAKQFASLGAKLILSARNEAELFRVKSEL--KGKYAPEDVKVLPLDLASGEEGLKHVV 404
E LA Q + LG L+LSAR EL RVK G +D+ VLPLDL + G
Sbjct: 64 EELAYQLSKLGVSLVLSARRVHELERVKRRCLENGNLKEKDILVLPLDLT--DTGSHEAA 121
Query: 405 EQAVSLFPGAGVDYLVHNAAYERPKSNAVDASEENLKTTFEVNVFGTISLTKLVTPHMLK 584
+AV L +D LV+N + +S +D S + + E+N GT+SLTK V PHM++
Sbjct: 122 TKAV-LQEFGRIDILVNNGGMSQ-RSLCMDTSLDVYRKLIELNYLGTVSLTKCVLPHMIE 179
Query: 585 QGGGHFVVISSAAGKVPSPGQAIYAASKHALQGYFHSLRSEF-FQKGIKVTVVCPGPIET 761
+ G V ++S G + P Y ASKHAL+G+F+ LR+E GI V+ +CPGP+++
Sbjct: 180 RKQGKIVTVNSILGIISVPLSIGYCASKHALRGFFNGLRTELATYPGIIVSNICPGPVQS 239
Query: 762 S------NGTGTSTSEDKKSPEKRVSSERCAELTIIAASHNLKEAWISYQPVLLVMYLVQ 923
+ G T T + ++++ RC L +I+ +++LKE WIS QP LLV YL Q
Sbjct: 240 NIVENSLAGEVTKTIGNNGDQSHKMTTSRCVRLMLISMANDLKEVWISEQPFLLVTYLWQ 299
Query: 924 YMPFLGFWLMDKVGGKRVE 980
YMP +W+ +K+G KR+E
Sbjct: 300 YMPTWAWWITNKMGKKRIE 318
>sp|Q9Y140|DHRS7_DROME Dehydrogenase/reductase SDR family protein 7-like
OS=Drosophila melanogaster GN=CG7601 PE=2 SV=1
Length = 326
Score = 145 bits (364), Expect = 1e-033
Identities = 106/285 (37%), Positives = 148/285 (51%), Gaps = 19/285 (6%)
Frame = +3
Query: 174 REAIEGKVVWITGASRGIGEVLAKQFASLGAKLILSARNEAELFRVKSELKG-----KYA 338
R + GKVV ITGAS G+GE LA F G ++IL+AR EL RVK +L Y
Sbjct: 48 RNQLPGKVVLITGASSGLGESLAHVFYRAGCRVILAARRTQELERVKKDLLALDVDPAYP 107
Query: 339 PEDVKVLPLDLASGEEGLKHVVEQAVSLFPGAGVDYLVHNAAYERPKSNAVDASEENLKT 518
P VLPLDLA + V + ++++ VD L++N A A + +LK
Sbjct: 108 P---TVLPLDLAE-LNSIPEFVTRVLAVY--NQVDILINNGGISVRADVASTAVDVDLK- 160
Query: 519 TFEVNVFGTISLTKLVTPHMLKQGGGHFVVISSAAGKVPSPGQAIYAASKHALQGYFHSL 698
VN FG+++LTK + P M+K+G GH ISS GK P +A Y+ASKHA+Q + SL
Sbjct: 161 VMVVNYFGSVALTKALLPSMVKRGSGHICFISSVQGKFAIPQRAAYSASKHAMQAFADSL 220
Query: 699 RSEFFQKGIKVTVVCPGPIETS------NGTGTSTSEDKKSPEKRVSSERCAELTIIAAS 860
R+E K I V+ V PG I T G+G+S + ++ K +S ++ AE +
Sbjct: 221 RAEVANKNINVSCVSPGYIRTQLSLNALTGSGSSYGKVDETTAKGMSPDKLAERILQCIL 280
Query: 861 HNLKEAWISYQPVLLVMYLVQYMPFLGFWLMDKVGGKRVEVAEKK 995
+ +S + YL P L FW+M K K +E AEKK
Sbjct: 281 RKEPDIIVSDVQAKIAYYLRHLCPSLYFWIMAKRAVK-LENAEKK 324
>sp|Q7Q732|DHRS7_ANOGA Dehydrogenase/reductase SDR family protein 7-like
OS=Anopheles gambiae GN=AGAP005532 PE=3 SV=3
Length = 317
Score = 127 bits (319), Expect = 2e-028
Identities = 99/303 (32%), Positives = 149/303 (49%), Gaps = 15/303 (4%)
Frame = +3
Query: 84 SLGLLLLLGLLLKFAFADGDLTLISKKHVKREA--IEGKVVWITGASRGIGEVLAKQFAS 257
SL LL L L A L L++ +R A + GKVV ITGAS G+GE LA F
Sbjct: 11 SLYWWLLATLFLPIAIPGLVLKLLTMMKEQRNARHLNGKVVLITGASSGLGEALAHSFFL 70
Query: 258 LGAKLILSARNEAELFRVKSELKGKYAPEDVK---VLPLDLASGEEGLKHVVEQAVSLFP 428
G K++L+AR + EL RV+ +L +A +LPLDL S + V+ + +
Sbjct: 71 AGCKVVLAARRKDELERVRKDLLELHATVPTHPPIILPLDL-SDLNSIGGKVQSVLEIH- 128
Query: 429 GAGVDYLVHNAAYERPKSNAVDASEENLKTTFEVNVFGTISLTKLVTPHMLKQGGGHFVV 608
+D LV+N A + +++ VN FG+++LTK P M+ + G V
Sbjct: 129 -GAIDILVNNGGISVRGDALSTAIDVDIRIML-VNYFGSVALTKACLPSMMARKEGRIVS 186
Query: 609 ISSAAGKVPSPGQAIYAASKHALQGYFHSLRSEFFQKGIKVTVVCPGPIETS------NG 770
ISS GK P ++ Y+ASKHA+Q + SLR+E + IKVT++ PG I T+ G
Sbjct: 187 ISSVQGKFAIPHRSAYSASKHAMQAFCDSLRAEVAKDNIKVTLISPGYINTALSLNALTG 246
Query: 771 TGTSTSEDKKSPEKRVSSERCAELTIIAASHNLKEAWISYQPVLLVMYLVQYMPFLGFWL 950
TG S + + S + A + A + + K+ ++ +L P + FW+
Sbjct: 247 TGASYGKMDAATAGGASPQDTASSILKAIARDEKDVMLAPIAPRAAYWLRHLAPSVYFWI 306
Query: 951 MDK 959
M K
Sbjct: 307 MKK 309
>sp|Q566S6|DRS7B_DANRE Dehydrogenase/reductase SDR family member 7B OS=Danio
rerio GN=dhrs7b PE=2 SV=1
Length = 309
Score = 121 bits (303), Expect = 1e-026
Identities = 75/211 (35%), Positives = 109/211 (51%), Gaps = 2/211 (0%)
Frame = +3
Query: 171 KREAIEGKVVWITGASRGIGEVLAKQFASLGAKLILSARNEAELFRVKSELKGKYAPEDV 350
+R I+ KVV ITGAS G+G+ A+ F + GA+LIL R++ L V EL K +
Sbjct: 31 RRPNIQDKVVVITGASSGLGKECARVFHAAGARLILCGRDQRRLQEVVEELGNKTYGKTK 90
Query: 351 KVLPLDLASGEEGLKHVVEQAVSLFPGAG-VDYLVHNAAYERPKSNAVDASEENLKTTFE 527
P + V A + G VD L+ N A + N +D + E
Sbjct: 91 TYTPCTVTFDLSNTSVVCSAAAEILKRHGHVDVLI-NIAGVSYRGNILDTHVSVQREVME 149
Query: 528 VNVFGTISLTKLVTPHMLKQGGGHFVVISSAAGKVPSPGQAIYAASKHALQGYFHSLRSE 707
N FG ++LT+ + P M+ +G GH VVISS GK+ P ++ YAASKHA+Q Y+ LR+E
Sbjct: 150 TNYFGPVALTQAILPSMVDRGSGHIVVISSVQGKISIPYRSAYAASKHAMQAYYDCLRAE 209
Query: 708 FFQKGIKVTVVCPGPIETSNGTGTSTSEDKK 800
G+ V+V+ PG + T+ T + K
Sbjct: 210 VDSLGLHVSVLSPGYVRTNMSINAVTGDGSK 240
>sp|Q5R6U1|DRS7B_PONAB Dehydrogenase/reductase SDR family member 7B OS=Pongo
abelii GN=DHRS7B PE=2 SV=2
Length = 325
Score = 121 bits (302), Expect = 2e-026
Identities = 99/305 (32%), Positives = 145/305 (47%), Gaps = 24/305 (7%)
Frame = +3
Query: 63 MLTLLFSSLGLLLLLGLLLKFAFADGDLTLISKKHVKREA-IEGKVVWITGASRGIGEVL 239
+L LLFS LG+ L LL + V+ +A + VV ITGA+ G+G+
Sbjct: 24 ILPLLFSCLGVFGLFRLL---------------QWVRGKAYLRNAVVVITGATSGLGKEC 68
Query: 240 AKQFASLGAKLILSARNEAELFRVKSELKGKYAPEDVKVLPLDLASGEEGLKHVVEQAVS 419
AK F + GAKL+L RN L + EL +A + P + +V A
Sbjct: 69 AKVFYAAGAKLVLCGRNGGALEELIRELTASHATKVQTHKPYLVTFDLTDSGAIVAAAAE 128
Query: 420 LFPGAG-VDYLVHNAAYERPKSNAVDASEENLKTTFEVNVFGTISLTKLVTPHMLKQGGG 596
+ G VD LV+NA + +D + + K E N FG ++LTK + P M+K+ G
Sbjct: 129 ILQCFGYVDILVNNAGISY-RGTIMDTTVDVDKRVMETNYFGPVALTKALLPSMIKRRQG 187
Query: 597 HFVVISSAAGKVPSPGQAIYAASKHALQGYFHSLRSEFFQKGIKVTVVCPGPIETSNGTG 776
H V ISS GK+ P ++ YAASKHA Q +F LR+E Q I+VTV+ PG I T+
Sbjct: 188 HIVAISSIQGKISIPFRSAYAASKHATQAFFDCLRAEMEQYEIEVTVISPGYIHTNLSVN 247
Query: 777 TSTSEDKK------SPEKRVSSERCAELTIIAASHNLKEAWISYQPVLLVMYLVQYMPFL 938
T++ + + + S A+ + A K+ ++ L +YL P L
Sbjct: 248 AVTADGSRYGVMDTTTAQGRSPVEVAQDVLAAVGKKKKDVILADLLPSLAVYLRTLAPGL 307
Query: 939 GFWLM 953
F LM
Sbjct: 308 FFSLM 312
>sp|Q6IAN0|DRS7B_HUMAN Dehydrogenase/reductase SDR family member 7B OS=Homo
sapiens GN=DHRS7B PE=1 SV=2
Length = 325
Score = 120 bits (299), Expect = 3e-026
Identities = 101/311 (32%), Positives = 150/311 (48%), Gaps = 15/311 (4%)
Frame = +3
Query: 45 SKPRKKMLTLLFSSLGLLLLLGLLLKFAFADGDLTLISKKHVKREA-IEGKVVWITGASR 221
S P+ K + + S+ L LL G L F G L+ + V+ +A + VV ITGA+
Sbjct: 9 SLPKVKAMDFITSTAILPLLFGCLGVF----GLFRLL--QWVRGKAYLRNAVVVITGATS 62
Query: 222 GIGEVLAKQFASLGAKLILSARNEAELFRVKSELKGKYAPEDVKVLPLDLASGEEGLKHV 401
G+G+ AK F + GAKL+L RN L + EL +A + P + +
Sbjct: 63 GLGKECAKVFYAAGAKLVLCGRNGGALEELIRELTASHATKVQTHKPYLVTFDLTDSGAI 122
Query: 402 VEQAVSLFPGAG-VDYLVHNAAYERPKSNAVDASEENLKTTFEVNVFGTISLTKLVTPHM 578
V A + G VD LV+NA + +D + + K E N FG ++LTK + P M
Sbjct: 123 VAAAAEILQCFGYVDILVNNAGISY-RGTIMDTTVDVDKRVMETNYFGPVALTKALLPSM 181
Query: 579 LKQGGGHFVVISSAAGKVPSPGQAIYAASKHALQGYFHSLRSEFFQKGIKVTVVCPGPIE 758
+K+ GH V ISS GK+ P ++ YAASKHA Q +F LR+E Q I+VTV+ PG I
Sbjct: 182 IKRRQGHIVAISSIQGKMSIPFRSAYAASKHATQAFFDCLRAEMEQYEIEVTVISPGYIH 241
Query: 759 TSNGTGTSTSEDKK------SPEKRVSSERCAELTIIAASHNLKEAWISYQPVLLVMYLV 920
T+ T++ + + + S A+ + A K+ ++ L +YL
Sbjct: 242 TNLSVNAITADGSRYGVMDTTTAQGRSPVEVAQDVLAAVGKKKKDVILADLLPSLAVYLR 301
Query: 921 QYMPFLGFWLM 953
P L F LM
Sbjct: 302 TLAPGLFFSLM 312
>sp|Q3T0R4|DRS7B_BOVIN Dehydrogenase/reductase SDR family member 7B OS=Bos
taurus GN=DHRS7B PE=2 SV=1
Length = 325
Score = 119 bits (296), Expect = 8e-026
Identities = 96/307 (31%), Positives = 145/307 (47%), Gaps = 13/307 (4%)
Frame = +3
Query: 54 RKKMLTLLFSSLGLLLLLGLLLKFAFADGDLTLISKKHVKREAIEGKVVWITGASRGIGE 233
R +++ + S+ L LLLG + F+ L + + R + VV ITGA+ G+G
Sbjct: 12 RARVMDFITSTAILPLLLGCVGLFS-----LFKLLQWLRMRAYVRNAVVVITGATSGLGR 66
Query: 234 VLAKQFASLGAKLILSARNEAELFRVKSELKGKYAPEDVKVLPLDLASGEEGLKHVVEQA 413
A+ F + GA+L+L RN L + EL AP P + + A
Sbjct: 67 ECARVFHAAGARLVLCGRNAEALEELSQELAASRAPGVQTHKPCTVTFDLADPGAIAGAA 126
Query: 414 VSLFPGAG-VDYLVHNAAYERPKSNAVDASEENLKTTFEVNVFGTISLTKLVTPHMLKQG 590
+ G VD L++NA + VD S + K E N FG ++LTK + P M+++
Sbjct: 127 SEILQCFGHVDVLINNAGISY-RGAIVDTSPDVDKRVMETNYFGPVALTKALLPAMIRRR 185
Query: 591 GGHFVVISSAAGKVPSPGQAIYAASKHALQGYFHSLRSEFFQKGIKVTVVCPGPIETSNG 770
GH V ISS GK+ P ++ YAASKHA Q +F LR+E Q I+VTV+ PG I T+
Sbjct: 186 QGHVVAISSIQGKISLPFRSAYAASKHATQAFFDCLRAEVEQHDIEVTVISPGYIHTNLS 245
Query: 771 TGTSTSEDKK------SPEKRVSSERCAELTIIAASHNLKEAWISYQPVLLVMYLVQYMP 932
T++ K + + S + A+ + A K+ ++ L +YL P
Sbjct: 246 LNAVTADGSKYGVMDETTAQGRSPVQVAQDILAALGKKKKDVVLADPMPSLAVYLRTLAP 305
Query: 933 FLGFWLM 953
L F LM
Sbjct: 306 GLFFRLM 312
>sp|Q0IH28|DRS7B_XENLA Dehydrogenase/reductase SDR family member 7B OS=Xenopus
laevis GN=dhrs7b PE=2 SV=1
Length = 323
Score = 115 bits (286), Expect = 1e-024
Identities = 87/274 (31%), Positives = 130/274 (47%), Gaps = 10/274 (3%)
Frame = +3
Query: 183 IEGKVVWITGASRGIGEVLAKQFASLGAKLILSARNEAELFRVKSELKGKYAPEDVKVLP 362
++ VV ITGA+ G+G+ AK F + G+ L+L R+E L + EL P
Sbjct: 34 LQAAVVVITGATSGLGKECAKVFYAAGSHLVLCGRDEERLKDLVQELNNMRLKSTQLHKP 93
Query: 363 LDLASGEEGLKHVVEQAVSLFPGAG-VDYLVHNAAYERPKSNAVDASEENLKTTFEVNVF 539
+ ++ V A + AG VD L++NA + +D + + N F
Sbjct: 94 HMVIFDLSDVEAVNTAAKEILHLAGRVDILINNAGISY-RGTILDTKVSVDRMVMDTNYF 152
Query: 540 GTISLTKLVTPHMLKQGGGHFVVISSAAGKVPSPGQAIYAASKHALQGYFHSLRSEFFQK 719
G ++LTK + P M+K GH VVISS GK+ P ++ Y+ASKHA Q +F LR+E
Sbjct: 153 GPVALTKALLPSMIKNRRGHVVVISSVQGKISIPFRSAYSASKHATQAFFDCLRAEMSPY 212
Query: 720 GIKVTVVCPGPIETSNGTGTSTSE-------DKKSPEKRVSSERCAELTIIAASHNLKEA 878
I VTVV PG I+T+ T + DK + + R + E A+ + A KE
Sbjct: 213 DIDVTVVNPGYIKTNLSLNAVTGDGSGYGVMDKNTADGR-TPEEVAQTVLRAVGERRKEL 271
Query: 879 WISYQPVLLVMYLVQYMPFLGFWLMDKVGGKRVE 980
++ L +YL P L F +M KR +
Sbjct: 272 LVAGLVPTLAVYLRTLAPTLFFSIMSARAKKRTK 305
>sp|Q99J47|DRS7B_MOUSE Dehydrogenase/reductase SDR family member 7B OS=Mus
musculus GN=Dhrs7b PE=2 SV=1
Length = 323
Score = 113 bits (282), Expect = 3e-024
Identities = 84/267 (31%), Positives = 131/267 (49%), Gaps = 16/267 (5%)
Frame = +3
Query: 183 IEGKVVWITGASRGIGEVLAKQFASLGAKLILSARNEAELFRVKSELKGKYAPEDVK--V 356
+ VV +TGA+ G+G AK F + GAKL+L RN L + EL G + + V
Sbjct: 50 LRNAVVVVTGATSGLGRECAKVFHAAGAKLVLCGRNVKALEELSRELAGSSQGQTHQPFV 109
Query: 357 LPLDLASGEEGLKHVVEQAVSLFPGAG-VDYLVHNAAYERPKSNAVDASEENLKTTFEVN 533
+ DLA + A + G VD L++NA + D + + E+N
Sbjct: 110 VTFDLADPGT----IAAAAAEILQCFGYVDVLINNAGISY-RGTISDTIVDVDRKVMEIN 164
Query: 534 VFGTISLTKLVTPHMLKQGGGHFVVISSAAGKVPSPGQAIYAASKHALQGYFHSLRSEFF 713
FG ++LTK + P M+++ GH V ISS GK+ P ++ Y+ASKHA Q +F LR+E
Sbjct: 165 YFGPVALTKALLPSMVERKQGHIVAISSIQGKISIPFRSAYSASKHATQAFFDCLRAEME 224
Query: 714 QKGIKVTVVCPGPIETSNGTGTSTSE-------DKKSPEKRVSSERCAELTIIAASHNLK 872
+ IKVTV+ PG I T+ T++ DK + + R ++E A+ A K
Sbjct: 225 EANIKVTVISPGYIHTNLSVNAVTADGSRYGALDKNTAQGRSAAE-VAQDVFDAVGKKKK 283
Query: 873 EAWISYQPVLLVMYLVQYMPFLGFWLM 953
+ ++ + +Y+ P L F +M
Sbjct: 284 DVLLTDFVPSMAVYIRTLAPGLFFRIM 310
>sp|Q0VFE7|DRS7B_XENTR Dehydrogenase/reductase SDR family member 7B OS=Xenopus
tropicalis GN=dhrs7b PE=2 SV=1
Length = 309
Score = 109 bits (270), Expect = 8e-023
Identities = 83/267 (31%), Positives = 127/267 (47%), Gaps = 14/267 (5%)
Frame = +3
Query: 183 IEGKVVWITGASRGIGEVLAKQFASLGAKLILSARNE---AELFRVKSELKGKYAPEDVK 353
++ VV ITGA+ G+G AK F + G +L+L R+E L + S+++ K A
Sbjct: 34 LQDAVVVITGATSGLGRECAKVFYAAGTRLVLCGRSEEGLKNLVQELSQMRIKSAQLHKP 93
Query: 354 VLPLDLASGEEGLKHVVEQAVSLFPGAGVDYLVHNAAYERPKSNAVDASEENLKTTFEVN 533
+ + S E + + + L VD L++NA + +D + + N
Sbjct: 94 HMVIFDLSDVEAVNSAANEILHL--TGRVDILINNAGISY-RGTILDTKVSVDRMVMDTN 150
Query: 534 VFGTISLTKLVTPHMLKQGGGHFVVISSAAGKVPSPGQAIYAASKHALQGYFHSLRSEFF 713
FG ++LTK + P M+K GH VVISS GK+ P ++ Y+ASKHA Q +F LR+E
Sbjct: 151 YFGPVALTKALIPSMIKNRRGHIVVISSVQGKISIPFRSAYSASKHATQAFFDCLRAEMS 210
Query: 714 QKGIKVTVVCPGPIETSNGTGTSTSE-------DKKSPEKRVSSERCAELTIIAASHNLK 872
I VTVV PG I+T+ T + D + E R + E A+ + A K
Sbjct: 211 PYEIDVTVVNPGYIKTNLSLNAVTGDGSNYGVMDNNTAEGR-TPEEVAQTVLRAVGERRK 269
Query: 873 EAWISYQPVLLVMYLVQYMPFLGFWLM 953
E ++ L +YL P + F M
Sbjct: 270 ELLVAGLVPTLAVYLRTLAPTIFFSFM 296
>sp|Q5RJY4|DRS7B_RAT Dehydrogenase/reductase SDR family member 7B OS=Rattus
norvegicus GN=Dhrs7b PE=1 SV=1
Length = 325
Score = 105 bits (260), Expect = 1e-021
Identities = 78/265 (29%), Positives = 125/265 (47%), Gaps = 10/265 (3%)
Frame = +3
Query: 183 IEGKVVWITGASRGIGEVLAKQFASLGAKLILSARNEAELFRVKSELKGKYAPEDVKVLP 362
+ VV +TGA+ G+G+ A+ F + GAK++L RN L EL + + P
Sbjct: 50 LRNAVVVVTGATSGLGKECARVFHAAGAKVVLCGRNVKALEEFTRELADSSSSQGQTHQP 109
Query: 363 LDLASGEEGLKHVVEQAVSLFPGAG-VDYLVHNAAYERPKSNAVDASEENLKTTFEVNVF 539
+ + A + G VD L++NA + D + + E+N F
Sbjct: 110 CVVTFDLADPGAIAPAAAEILQCFGYVDILINNAGISY-RGAISDTIVDVDRKVMEINYF 168
Query: 540 GTISLTKLVTPHMLKQGGGHFVVISSAAGKVPSPGQAIYAASKHALQGYFHSLRSEFFQK 719
G ++LTK + P M+++ GH V ISS GK+ P ++ YAASKHA Q +F LR+E
Sbjct: 169 GPVALTKALLPSMVERKRGHIVAISSIQGKISIPFRSAYAASKHATQAFFDCLRAEMKDS 228
Query: 720 GIKVTVVCPGPIETSNGTGTSTSE-------DKKSPEKRVSSERCAELTIIAASHNLKEA 878
I+VTV+ PG I T+ T++ DK + + R S+ A+ A K+
Sbjct: 229 DIEVTVISPGYIHTNLSVNAVTADGSRYGALDKNTAQGR-SAVEVAQDIFDAVGKKKKDV 287
Query: 879 WISYQPVLLVMYLVQYMPFLGFWLM 953
++ + +Y+ P L F +M
Sbjct: 288 LLTDFLPTMAVYIRTLAPRLFFRIM 312
>sp|Q9BTZ2|DHRS4_HUMAN Dehydrogenase/reductase SDR family member 4 OS=Homo
sapiens GN=DHRS4 PE=1 SV=2
Length = 260
Score = 102 bits (253), Expect = 7e-021
Identities = 68/198 (34%), Positives = 104/198 (52%), Gaps = 5/198 (2%)
Frame = +3
Query: 171 KREAIEGKVVWITGASRGIGEVLAKQFASLGAKLILSARNEAELFRVKSELKGKYAPEDV 350
+R+ + KV +T ++ GIG +A++ A GA +++S+R + + + + L+G+
Sbjct: 8 RRDPLANKVALVTASTDGIGFAIARRLAQDGAHVVVSSRKQQNVDQAVATLQGEGLSVTG 67
Query: 351 KVLPLDLASGEEGLKHVVEQAVSLFPGAGVDYLVHNAAYERPKSNAVDASEENLKTTFEV 530
V + A E L V AV L G+D LV NAA + +D +EE T ++
Sbjct: 68 TVCHVGKAEDRERL---VATAVKLH--GGIDILVSNAAVNPFFGSIMDVTEEVWDKTLDI 122
Query: 531 NVFGTISLTKLVTPHMLKQGGGHFVVISSAAGKVPSPGQAIYAASKHALQGYFHSLRSEF 710
NV +TK V P M K+GGG V++SS A PSPG + Y SK AL G +L E
Sbjct: 123 NVKAPALMTKAVVPEMEKRGGGSVVIVSSIAAFSPSPGFSPYNVSKTALLGLTKTLAIEL 182
Query: 711 FQKGIKVTVVCPGPIETS 764
+ I+V + PG I+TS
Sbjct: 183 APRNIRVNCLAPGLIKTS 200
>sp|Q5RCF8|DHRS4_PONAB Dehydrogenase/reductase SDR family member 4 OS=Pongo
abelii GN=DHRS4 PE=2 SV=2
Length = 260
Score = 102 bits (253), Expect = 7e-021
Identities = 68/198 (34%), Positives = 104/198 (52%), Gaps = 5/198 (2%)
Frame = +3
Query: 171 KREAIEGKVVWITGASRGIGEVLAKQFASLGAKLILSARNEAELFRVKSELKGKYAPEDV 350
+R+ + KV +T ++ GIG +A++ A GA +++S+R + + + + L+G+
Sbjct: 8 RRDPLANKVALVTASTDGIGFAIARRLAQDGAHVVVSSRKQQNVDQAVATLQGEGLSVTG 67
Query: 351 KVLPLDLASGEEGLKHVVEQAVSLFPGAGVDYLVHNAAYERPKSNAVDASEENLKTTFEV 530
V + A E L V AV L G+D LV NAA + +D +EE T ++
Sbjct: 68 TVCHVGKAEDRERL---VATAVKLH--GGIDILVSNAAVNPFFGSLMDVTEEVWDKTLDI 122
Query: 531 NVFGTISLTKLVTPHMLKQGGGHFVVISSAAGKVPSPGQAIYAASKHALQGYFHSLRSEF 710
NV +TK V P M K+GGG V++SS A PSPG + Y SK AL G +L E
Sbjct: 123 NVKAPALMTKAVVPEMEKRGGGSVVIVSSIAAFSPSPGFSPYNVSKTALLGLTKTLAIEL 182
Query: 711 FQKGIKVTVVCPGPIETS 764
+ I+V + PG I+TS
Sbjct: 183 APRNIRVNCLAPGLIKTS 200
>sp|P54554|YQJQ_BACSU Uncharacterized oxidoreductase yqjQ OS=Bacillus subtilis
GN=yqjQ PE=3 SV=1
Length = 259
Score = 97 bits (239), Expect = 3e-019
Identities = 48/108 (44%), Positives = 75/108 (69%), Gaps = 1/108 (0%)
Frame = +3
Query: 438 VDYLVHNAAYERPKSNAVDASEENLKTTFEVNVFGTISLTKLVTPHMLKQGGGHFVVISS 617
+D L++NA + ++ +D++ +++K F+VNVFG I+ TK V P ML+Q GH + I+S
Sbjct: 81 IDVLINNAGFGIFET-VLDSTLDDMKAMFDVNVFGLIACTKAVLPQMLEQKKGHIINIAS 139
Query: 618 AAGKVPSPGQAIYAASKHALQGYFHSLRSEFFQKGIKVTVVCPGPIET 761
AGK+ +P ++Y+A+KHA+ GY ++LR E GI VT V PGPI+T
Sbjct: 140 QAGKIATPKSSLYSATKHAVLGYSNALRMELSGTGIYVTTVNPGPIQT 187
>sp|Q5BL28|DS7CB_DANRE Dehydrogenase/reductase SDR family member 7C-B OS=Danio
rerio GN=dhrs7cb PE=2 SV=1
Length = 318
Score = 96 bits (238), Expect = 4e-019
Identities = 78/272 (28%), Positives = 129/272 (47%), Gaps = 13/272 (4%)
Frame = +3
Query: 165 HVKREAIEGKVVWITGASRGIGEVLAKQFASLGAKLILSARNEAELFRVKSELKGKYAPE 344
H+ + + KVV IT + +G AK F + GA+LIL N +L + +L + P
Sbjct: 37 HLAKTTVRNKVVLITDSLSTVGNECAKLFHAGGARLILCGSNWEKLEALAEQLTSQSDPT 96
Query: 345 ---DVKVLPLDLASGEEGLKHVVEQAVSLFPGAGVDYLVHNAAYERPKSNAVDASEENLK 515
K++ LD S E + V+ + + F +D LV N++ + K+ S + +
Sbjct: 97 LTFPPKLVELDF-SDMESVPEVISEILECF--CCLDVLVFNSSM-KLKAPVHSLSLQMDR 152
Query: 516 TTFEVNVFGTISLTKLVTPHMLKQGGGHFVVISSAAGKVPSPGQAIYAASKHALQGYFHS 695
+VN FG I+L K P ++ + GH ++++S GK+ P + YAASKHA+Q +F
Sbjct: 153 LLMDVNYFGPITLVKGFLPSLISRRSGHILLVNSIQGKLAMPFRTTYAASKHAVQAFFEC 212
Query: 696 LRSEFFQKGIKVTVVCPGPIETSNG------TGTSTSEDKKSPEKRVSSERCAELTIIAA 857
LR+E + GI V+ + I+TS+ T S D + VS + A +
Sbjct: 213 LRAEVQEYGITVSTINHTFIKTSSSIPKDEITARSMKTDHRQTPLGVSPKDVATELLRTL 272
Query: 858 SHNLKEAWISYQPVLLVMYLVQYMPFLGFWLM 953
S KE ++ +Y+ P L F +M
Sbjct: 273 SSKKKEILMARWVPKAALYVRSLFPNLFFAIM 304
>sp|Q6PKH6|DR4L2_HUMAN Dehydrogenase/reductase SDR family member 4-like 2
OS=Homo sapiens GN=DHRS4L2 PE=2 SV=1
Length = 230
Score = 95 bits (235), Expect = 9e-019
Identities = 66/202 (32%), Positives = 104/202 (51%), Gaps = 5/202 (2%)
Frame = +3
Query: 126 AFADGDLTLISKKHVKREAIEGKVVWITGASRGIGEVLAKQFASLGAKLILSARNEAELF 305
A+A + L S + +R+ + KV +T ++ GIG +A++ A A +++S+R + +
Sbjct: 9 AWARKSVRLASSRMTRRDPLTNKVALVTASTDGIGFAIARRLAQDRAHVVVSSRKQQNVD 68
Query: 306 RVKSELKGKYAPEDVKVLPLDLASGEEGLKHVVEQAVSLFPGAGVDYLVHNAAYERPKSN 485
+ + L+G+ V + A E L V AV L G+D LV NAA +
Sbjct: 69 QAVATLQGEGLSVTGTVCHVGKAEDRERL---VAMAVKLH--GGIDILVSNAAVNPFFGS 123
Query: 486 AVDASEENLKTTFEVNVFGTISLTKLVTPHMLKQGGGHFVVISSAAGKVPSPGQAIYAAS 665
+D +EE T ++NV +TK V P M K+GGG V++SS A PSPG + Y S
Sbjct: 124 LMDVTEEVWDKTLDINVKAPALMTKAVVPEMEKRGGGSVVIVSSIAAFSPSPGFSPYNVS 183
Query: 666 KHALQGYFHSLRSEFFQKGIKV 731
K AL G ++L E + I+V
Sbjct: 184 KTALLGLNNTLAIELAPRNIRV 205
>sp|A9UM79|DRS7C_XENTR Dehydrogenase/reductase SDR family member 7C OS=Xenopus
tropicalis GN=dhrs7c PE=2 SV=1
Length = 311
Score = 94 bits (233), Expect = 2e-018
Identities = 63/198 (31%), Positives = 104/198 (52%), Gaps = 11/198 (5%)
Frame = +3
Query: 168 VKREAIEGKVVWITGASRGIGEVLAKQFASLGAKLILSARNEAELFRVKSELKGKYAPE- 344
+ R A++ KVV IT A G+G+ ++ F S GA+L+L + +L + L P
Sbjct: 30 MSRSALKNKVVVITDAISGLGKECSRVFHSAGARLVLCGKTWEKLEALHDALISVADPSV 89
Query: 345 --DVKVLPLDLA--SGEEGLKHVVEQAVSLFPGAGVDYLVHNAAYERPKSNAVDASEENL 512
K++ LD++ + E + ++ VD L++NA+ + K S E
Sbjct: 90 TFTPKLVLLDISDINNMEAMGKEIQDCYGC-----VDVLINNASM-KMKGPLQSVSLELD 143
Query: 513 KTTFEVNVFGTISLTKLVTPHMLKQGGGHFVVISSAAGKVPSPGQAIYAASKHALQGYFH 692
K + N FG I+L K + PHM+ + G V++++ GK+ P +A YAASKHA+QG+F
Sbjct: 144 KKIMDANYFGPITLVKAILPHMISRRTGQIVLVNTIQGKIGVPFRAAYAASKHAIQGFFD 203
Query: 693 SLRSEFFQKGIKVTVVCP 746
LR+E + + V+ V P
Sbjct: 204 CLRAEVEEFDVSVSTVSP 221
>sp|A8E5C5|DS7CA_DANRE Dehydrogenase/reductase SDR family member 7C-A OS=Danio
rerio GN=dhrs7ca PE=2 SV=1
Length = 324
Score = 91 bits (225), Expect = 1e-017
Identities = 71/222 (31%), Positives = 111/222 (50%), Gaps = 9/222 (4%)
Frame = +3
Query: 162 KHVKREAIEGKVVWITGASRGIGEVLAKQFASLGAKLILSARNEAELFRVKSELKGKYAP 341
+ + + + KVV IT A G+G A+ F + GA+L+L + +L + L P
Sbjct: 28 RFMSKSVVRNKVVVITDAVSGMGSECARLFHAGGARLVLCGPSWDKLESLYDSLCSGSDP 87
Query: 342 EDV---KVLPLDLASGEEGLKHVVEQAVSLFPGAGVDYLVHNAAYERPKSNAVDASEENL 512
K++ LD S E + VV + + VD L+ N++ + K+ + S E
Sbjct: 88 SQTFTPKLVLLDF-SDMENISDVVSEICECY--GCVDVLICNSSM-KVKAPVQNLSLEMD 143
Query: 513 KTTFEVNVFGTISLTKLVTPHMLKQGGGHFVVISSAAGKVPSPGQAIYAASKHALQGYFH 692
KT +VN FG I+L K V P M+ + G FV+++S GK+ P + YAASKHA+Q +F
Sbjct: 144 KTIMDVNYFGPITLAKGVLPLMITRRTGQFVLVNSIQGKLALPFRTCYAASKHAVQAFFD 203
Query: 693 SLRSEFFQKGIKVTVVCPGPIE--TSNGTGTSTSEDKKSPEK 812
LR+E + GI V+ + I N T T + +P K
Sbjct: 204 CLRAEVEEFGISVSTISHTFINAGAENATPTEATPITATPTK 245
>sp|Q9X248|FABG_THEMA 3-oxoacyl-[acyl-carrier-protein] reductase OS=Thermotoga
maritima GN=fabG PE=3 SV=1
Length = 246
Score = 91 bits (225), Expect = 1e-017
Identities = 67/192 (34%), Positives = 95/192 (49%), Gaps = 12/192 (6%)
Frame = +3
Query: 195 VVWITGASRGIGEVLAKQFASLGAKLI---LSARNEAELFRVKSELKGKYAPEDVKVLPL 365
V ITGA+ GIG+ FA GA +I +S N L + L GK P + V
Sbjct: 7 VCLITGAASGIGKATTLLFAQEGATVIAGDISKENLDSLVKEAEGLPGKVDPYVLNV--- 63
Query: 366 DLASGEEGLKHVVEQAVSLFPGAGVDYLVHNAAYERPKSNAVDASEENLKTTFEVNVFGT 545
+ + +K VVE+ V + +D LV+NA R + V EE+ VN+ G
Sbjct: 64 ---TDRDQIKEVVEKVVQKY--GRIDVLVNNAGITR-DALLVRMKEEDWDAVINVNLKGV 117
Query: 546 ISLTKLVTPHMLKQGGGHFVVISSAAGKVPSPGQAIYAASKHALQGYFHSLRSEFFQKGI 725
++T++V P+M+KQ G V +SS G +PGQ YAASK + G + E + I
Sbjct: 118 FNVTQMVVPYMIKQRNGSIVNVSSVVGIYGNPGQTNYAASKAGVIGMTKTWAKELAGRNI 177
Query: 726 KVTVVCPGPIET 761
+V V PG IET
Sbjct: 178 RVNAVAPGFIET 189
>sp|Q8CHS7|DRS7C_MOUSE Dehydrogenase/reductase SDR family member 7C OS=Mus
musculus GN=Dhrs7c PE=2 SV=3
Length = 311
Score = 90 bits (222), Expect = 3e-017
Identities = 70/225 (31%), Positives = 118/225 (52%), Gaps = 9/225 (4%)
Frame = +3
Query: 87 LGLLLLLGLLLKFAFADGDLTLI--SKKHVKREAIEGKVVWITGASRGIGEVLAKQFASL 260
+GL+ +L L L G L + + + + A++ KVV IT A G+G+ A+ F +
Sbjct: 1 MGLMAVLMLPLLLLGISGLLFIYQEASRLWSKSAVQNKVVVITDAISGLGKECARVFHAG 60
Query: 261 GAKLILSARNEAELFRVKSELKGKYAPEDV---KVLPLDLASGEEGLKHVVEQAVSLFPG 431
GA+L+L +N L + + L P K++ LDL S ++ V ++ + +
Sbjct: 61 GARLVLCGKNWEGLESLYATLTSVADPSKTFTPKLVLLDL-SDISCVQDVAKEVLDCY-- 117
Query: 432 AGVDYLVHNAAYERPKSNAVDASEENLKTTFEVNVFGTISLTKLVTPHMLKQGGGHFVVI 611
VD L++NA+ + K A S E K + N FG I+LTK++ P+M+ + G V++
Sbjct: 118 GCVDILINNASV-KVKGPAHKISLELDKKIMDANYFGPITLTKVLLPNMISRRTGQIVLV 176
Query: 612 SSAAGKVPSPGQAIYAASKHALQGYFHSLRSEFFQKGIKVTVVCP 746
++ K P + YAASKHA+ G+F LR+E + + V+ V P
Sbjct: 177 NNIQAKFGIPFRTAYAASKHAVMGFFDCLRAEVEEYDVVVSTVSP 221
Database: UniProt/SwissProt
Posted date: Sat Aug 07 14:36:18 2010
Number of letters in database: 182,829,261
Number of sequences in database: 518,415
Lambda K H
0.267 0.041 0.140
Gapped
Lambda K H
0.267 0.041 0.140
Matrix: blosum62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 98,767,994,010
Number of Sequences: 518415
Number of Extensions: 98767994010
Number of Successful Extensions: 632508636
Number of sequences better than 0.0: 0
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