BLASTX 7.6.2
Query= RU02749 /QuerySize=716
(715 letters)
Database: UniProt/Swiss-Prot;
462,764 sequences; 163,773,382 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P62194|PRS8_BOVIN 26S protease regulatory subunit 8 OS=Bos ta... 234 4e-061
sp|P62195|PRS8_HUMAN 26S protease regulatory subunit 8 OS=Homo s... 234 4e-061
sp|P62196|PRS8_MOUSE 26S protease regulatory subunit 8 OS=Mus mu... 234 4e-061
sp|P62197|PRS8_PIG 26S protease regulatory subunit 8 OS=Sus scro... 234 4e-061
sp|P62198|PRS8_RAT 26S protease regulatory subunit 8 OS=Rattus n... 234 4e-061
sp|P34124|PRS8_DICDI 26S protease regulatory subunit 8 OS=Dictyo... 230 8e-060
sp|O18413|PRS8_DROME 26S protease regulatory subunit 8 OS=Drosop... 230 8e-060
sp|P54814|PRS8_MANSE 26S protease regulatory subunit 8 OS=Manduc... 229 2e-059
sp|P46470|PRS8_XENLA 26S protease regulatory subunit 8 OS=Xenopu... 228 2e-059
sp|P41836|PRS8_SCHPO 26S protease regulatory subunit 8 homolog O... 224 6e-058
sp|Q25544|PRS8_NAEFO 26S protease regulatory subunit 8 homolog O... 222 2e-057
sp|Q01939|PRS8_YEAST 26S protease regulatory subunit 8 homolog O... 212 2e-054
sp|O26824|PSMR_METTH Proteasome-activating nucleotidase OS=Metha... 108 4e-023
sp|O28303|PSMR_ARCFU Proteasome-activating nucleotidase OS=Archa... 99 3e-020
sp|Q8TX03|PSMR_METKA Proteasome-activating nucleotidase OS=Metha... 99 3e-020
sp|Q58576|PSMR_METJA Proteasome-activating nucleotidase OS=Metha... 98 5e-020
sp|A7I8B8|PSMR_METB6 Proteasome-activating nucleotidase OS=Metha... 96 1e-019
sp|O16368|PRS4_CAEEL Probable 26S protease regulatory subunit 4 ... 94 5e-019
sp|A3CV35|PSMR_METMJ Proteasome-activating nucleotidase OS=Metha... 94 7e-019
sp|Q90732|PRS4_CHICK 26S protease regulatory subunit 4 OS=Gallus... 94 9e-019
sp|P53549|PRS10_YEAST 26S protease subunit RPT4 OS=Saccharomyces... 93 2e-018
sp|Q2FQ56|PSMR_METHJ Proteasome-activating nucleotidase OS=Metha... 93 2e-018
sp|Q0W257|PSMR_UNCMA Proteasome-activating nucleotidase OS=Uncul... 92 2e-018
sp|P62191|PRS4_HUMAN 26S protease regulatory subunit 4 OS=Homo s... 92 3e-018
sp|P62192|PRS4_MOUSE 26S protease regulatory subunit 4 OS=Mus mu... 92 3e-018
sp|P62193|PRS4_RAT 26S protease regulatory subunit 4 OS=Rattus n... 92 3e-018
sp|Q980M1|PSMR_SULSO Proteasome-activating nucleotidase OS=Sulfo... 91 8e-018
sp|Q5E9F9|PRS7_BOVIN 26S protease regulatory subunit 7 OS=Bos ta... 89 2e-017
sp|P35998|PRS7_HUMAN 26S protease regulatory subunit 7 OS=Homo s... 89 2e-017
sp|Q4R4R0|PRS7_MACFA 26S protease regulatory subunit 7 OS=Macaca... 89 2e-017
>sp|P62194|PRS8_BOVIN 26S protease regulatory subunit 8 OS=Bos taurus GN=PSMC5
PE=2 SV=1
Length = 406
Score = 234 bits (596), Expect = 4e-061
Identities = 120/178 (67%), Positives = 135/178 (75%)
Frame = -1
Query: 535 KLAASKLGEGLRPYYLQHIHELQLQVRQKTHNLNRLEAQRNELNSRVRMLRXXXXXXXXP 356
+L K G GLR YYL I ELQL V K+ NL RL+AQRNELN++VR+LR
Sbjct: 10 ELEEGKAGSGLRQYYLSKIEELQLIVNDKSQNLRRLQAQRNELNAKVRLLREELQLLQEQ 69
Query: 355 GSYVGEVVNVMGKNKVLVKVHPEGKYVVXXXXXXXXXXXXPSTRVALRNDSYVLHLVLPS 176
GSYVGEVV M K KVLVKVHPEGK+VV P+ RVALRNDSY LH +LP+
Sbjct: 70 GSYVGEVVRAMDKKKVLVKVHPEGKFVVDVDKNIDINDVTPNCRVALRNDSYTLHKILPN 129
Query: 175 KVDPLVNLMKVEKVPDSTYDMIGGLDQQIKEIKEVIELPIKHPELFESLGIAQPKGVL 2
KVDPLV+LM VEKVPDSTY+MIGGLD+QIKEIKEVIELP+KHPELFE+LGIAQPKGVL
Sbjct: 130 KVDPLVSLMMVEKVPDSTYEMIGGLDKQIKEIKEVIELPVKHPELFEALGIAQPKGVL 187
>sp|P62195|PRS8_HUMAN 26S protease regulatory subunit 8 OS=Homo sapiens GN=PSMC5
PE=1 SV=1
Length = 406
Score = 234 bits (596), Expect = 4e-061
Identities = 120/178 (67%), Positives = 135/178 (75%)
Frame = -1
Query: 535 KLAASKLGEGLRPYYLQHIHELQLQVRQKTHNLNRLEAQRNELNSRVRMLRXXXXXXXXP 356
+L K G GLR YYL I ELQL V K+ NL RL+AQRNELN++VR+LR
Sbjct: 10 ELEEGKAGSGLRQYYLSKIEELQLIVNDKSQNLRRLQAQRNELNAKVRLLREELQLLQEQ 69
Query: 355 GSYVGEVVNVMGKNKVLVKVHPEGKYVVXXXXXXXXXXXXPSTRVALRNDSYVLHLVLPS 176
GSYVGEVV M K KVLVKVHPEGK+VV P+ RVALRNDSY LH +LP+
Sbjct: 70 GSYVGEVVRAMDKKKVLVKVHPEGKFVVDVDKNIDINDVTPNCRVALRNDSYTLHKILPN 129
Query: 175 KVDPLVNLMKVEKVPDSTYDMIGGLDQQIKEIKEVIELPIKHPELFESLGIAQPKGVL 2
KVDPLV+LM VEKVPDSTY+MIGGLD+QIKEIKEVIELP+KHPELFE+LGIAQPKGVL
Sbjct: 130 KVDPLVSLMMVEKVPDSTYEMIGGLDKQIKEIKEVIELPVKHPELFEALGIAQPKGVL 187
>sp|P62196|PRS8_MOUSE 26S protease regulatory subunit 8 OS=Mus musculus GN=Psmc5
PE=1 SV=1
Length = 406
Score = 234 bits (596), Expect = 4e-061
Identities = 120/178 (67%), Positives = 135/178 (75%)
Frame = -1
Query: 535 KLAASKLGEGLRPYYLQHIHELQLQVRQKTHNLNRLEAQRNELNSRVRMLRXXXXXXXXP 356
+L K G GLR YYL I ELQL V K+ NL RL+AQRNELN++VR+LR
Sbjct: 10 ELEEGKAGSGLRQYYLSKIEELQLIVNDKSQNLRRLQAQRNELNAKVRLLREELQLLQEQ 69
Query: 355 GSYVGEVVNVMGKNKVLVKVHPEGKYVVXXXXXXXXXXXXPSTRVALRNDSYVLHLVLPS 176
GSYVGEVV M K KVLVKVHPEGK+VV P+ RVALRNDSY LH +LP+
Sbjct: 70 GSYVGEVVRAMDKKKVLVKVHPEGKFVVDVDKNIDINDVTPNCRVALRNDSYTLHKILPN 129
Query: 175 KVDPLVNLMKVEKVPDSTYDMIGGLDQQIKEIKEVIELPIKHPELFESLGIAQPKGVL 2
KVDPLV+LM VEKVPDSTY+MIGGLD+QIKEIKEVIELP+KHPELFE+LGIAQPKGVL
Sbjct: 130 KVDPLVSLMMVEKVPDSTYEMIGGLDKQIKEIKEVIELPVKHPELFEALGIAQPKGVL 187
>sp|P62197|PRS8_PIG 26S protease regulatory subunit 8 OS=Sus scrofa GN=PSMC5
PE=2 SV=1
Length = 406
Score = 234 bits (596), Expect = 4e-061
Identities = 120/178 (67%), Positives = 135/178 (75%)
Frame = -1
Query: 535 KLAASKLGEGLRPYYLQHIHELQLQVRQKTHNLNRLEAQRNELNSRVRMLRXXXXXXXXP 356
+L K G GLR YYL I ELQL V K+ NL RL+AQRNELN++VR+LR
Sbjct: 10 ELEEGKAGSGLRQYYLSKIEELQLIVNDKSQNLRRLQAQRNELNAKVRLLREELQLLQEQ 69
Query: 355 GSYVGEVVNVMGKNKVLVKVHPEGKYVVXXXXXXXXXXXXPSTRVALRNDSYVLHLVLPS 176
GSYVGEVV M K KVLVKVHPEGK+VV P+ RVALRNDSY LH +LP+
Sbjct: 70 GSYVGEVVRAMDKKKVLVKVHPEGKFVVDVDKNIDINDVTPNCRVALRNDSYTLHKILPN 129
Query: 175 KVDPLVNLMKVEKVPDSTYDMIGGLDQQIKEIKEVIELPIKHPELFESLGIAQPKGVL 2
KVDPLV+LM VEKVPDSTY+MIGGLD+QIKEIKEVIELP+KHPELFE+LGIAQPKGVL
Sbjct: 130 KVDPLVSLMMVEKVPDSTYEMIGGLDKQIKEIKEVIELPVKHPELFEALGIAQPKGVL 187
>sp|P62198|PRS8_RAT 26S protease regulatory subunit 8 OS=Rattus norvegicus
GN=Psmc5 PE=1 SV=1
Length = 406
Score = 234 bits (596), Expect = 4e-061
Identities = 120/178 (67%), Positives = 135/178 (75%)
Frame = -1
Query: 535 KLAASKLGEGLRPYYLQHIHELQLQVRQKTHNLNRLEAQRNELNSRVRMLRXXXXXXXXP 356
+L K G GLR YYL I ELQL V K+ NL RL+AQRNELN++VR+LR
Sbjct: 10 ELEEGKAGSGLRQYYLSKIEELQLIVNDKSQNLRRLQAQRNELNAKVRLLREELQLLQEQ 69
Query: 355 GSYVGEVVNVMGKNKVLVKVHPEGKYVVXXXXXXXXXXXXPSTRVALRNDSYVLHLVLPS 176
GSYVGEVV M K KVLVKVHPEGK+VV P+ RVALRNDSY LH +LP+
Sbjct: 70 GSYVGEVVRAMDKKKVLVKVHPEGKFVVDVDKNIDINDVTPNCRVALRNDSYTLHKILPN 129
Query: 175 KVDPLVNLMKVEKVPDSTYDMIGGLDQQIKEIKEVIELPIKHPELFESLGIAQPKGVL 2
KVDPLV+LM VEKVPDSTY+MIGGLD+QIKEIKEVIELP+KHPELFE+LGIAQPKGVL
Sbjct: 130 KVDPLVSLMMVEKVPDSTYEMIGGLDKQIKEIKEVIELPVKHPELFEALGIAQPKGVL 187
>sp|P34124|PRS8_DICDI 26S protease regulatory subunit 8 OS=Dictyostelium
discoideum GN=psmC5 PE=2 SV=2
Length = 403
Score = 230 bits (585), Expect = 8e-060
Identities = 112/170 (65%), Positives = 136/170 (80%)
Frame = -1
Query: 511 EGLRPYYLQHIHELQLQVRQKTHNLNRLEAQRNELNSRVRMLRXXXXXXXXPGSYVGEVV 332
+G++ YY I EL+++V +K +L RLEAQRNELN+RVRML+ PGS+V EVV
Sbjct: 14 KGIKSYYCSKIEELEIKVNEKAQDLRRLEAQRNELNNRVRMLKEELQLLTNPGSHVAEVV 73
Query: 331 NVMGKNKVLVKVHPEGKYVVXXXXXXXXXXXXPSTRVALRNDSYVLHLVLPSKVDPLVNL 152
+MGKNKVLVKV+PEGK+VV PSTR AL+++SY LH +LP+K+DPLV+L
Sbjct: 74 KLMGKNKVLVKVNPEGKFVVDIDPTVDIAKLTPSTRAALKHESYTLHRILPNKIDPLVSL 133
Query: 151 MKVEKVPDSTYDMIGGLDQQIKEIKEVIELPIKHPELFESLGIAQPKGVL 2
MKVEK+PDSTYDM+GGLD+QIKEIKEVIELPIKHPELFESLGIAQPKGVL
Sbjct: 134 MKVEKIPDSTYDMVGGLDKQIKEIKEVIELPIKHPELFESLGIAQPKGVL 183
>sp|O18413|PRS8_DROME 26S protease regulatory subunit 8 OS=Drosophila
melanogaster GN=Pros45 PE=1 SV=2
Length = 405
Score = 230 bits (585), Expect = 8e-060
Identities = 116/171 (67%), Positives = 133/171 (77%)
Frame = -1
Query: 514 GEGLRPYYLQHIHELQLQVRQKTHNLNRLEAQRNELNSRVRMLRXXXXXXXXPGSYVGEV 335
GEG R YY+Q I ELQL V +K NL RL+AQRNELN++VRMLR GSYVGEV
Sbjct: 16 GEGFRSYYIQKIEELQLVVAEKHQNLRRLQAQRNELNAKVRMLREELQLLQEQGSYVGEV 75
Query: 334 VNVMGKNKVLVKVHPEGKYVVXXXXXXXXXXXXPSTRVALRNDSYVLHLVLPSKVDPLVN 155
V M K KVLVKVHPEGK+VV P+ RVALRN+SY LH +LP+KVDPLV+
Sbjct: 76 VKPMDKKKVLVKVHPEGKFVVDLDKNIDINDVTPNCRVALRNESYTLHKILPNKVDPLVS 135
Query: 154 LMKVEKVPDSTYDMIGGLDQQIKEIKEVIELPIKHPELFESLGIAQPKGVL 2
LM VEKVPDSTY+M+GGLD+QIKEIKEVIELP+KHPELF++LGIAQPKGVL
Sbjct: 136 LMMVEKVPDSTYEMVGGLDKQIKEIKEVIELPVKHPELFDALGIAQPKGVL 186
>sp|P54814|PRS8_MANSE 26S protease regulatory subunit 8 OS=Manduca sexta PE=2
SV=1
Length = 402
Score = 229 bits (582), Expect = 2e-059
Identities = 116/174 (66%), Positives = 134/174 (77%)
Frame = -1
Query: 523 SKLGEGLRPYYLQHIHELQLQVRQKTHNLNRLEAQRNELNSRVRMLRXXXXXXXXPGSYV 344
S GEG RPYY+ I ELQL V +K+ NL RL+AQRNELN++VRMLR GSYV
Sbjct: 10 STKGEGFRPYYITKIEELQLIVAEKSQNLRRLQAQRNELNAKVRMLREELQLLQEQGSYV 69
Query: 343 GEVVNVMGKNKVLVKVHPEGKYVVXXXXXXXXXXXXPSTRVALRNDSYVLHLVLPSKVDP 164
GEVV M K KVLVKVHPEGK+VV + RVALRN+SY LH +LP+KVDP
Sbjct: 70 GEVVKPMDKKKVLVKVHPEGKFVVDLDKNVDINDVTANCRVALRNESYTLHKILPNKVDP 129
Query: 163 LVNLMKVEKVPDSTYDMIGGLDQQIKEIKEVIELPIKHPELFESLGIAQPKGVL 2
LV+LM VEKVPDSTY+M+GGLD+QIKEIKEVIELP+KHPELF++LGIAQPKGVL
Sbjct: 130 LVSLMMVEKVPDSTYEMVGGLDKQIKEIKEVIELPVKHPELFDALGIAQPKGVL 183
>sp|P46470|PRS8_XENLA 26S protease regulatory subunit 8 OS=Xenopus laevis
GN=psmc5 PE=2 SV=2
Length = 461
Score = 228 bits (581), Expect = 2e-059
Identities = 117/174 (67%), Positives = 133/174 (76%)
Frame = -1
Query: 523 SKLGEGLRPYYLQHIHELQLQVRQKTHNLNRLEAQRNELNSRVRMLRXXXXXXXXPGSYV 344
S+ G GLR YYL I +LQL V K+ NL RL+AQRNELN++VR+LR GSYV
Sbjct: 9 SRGGTGLRQYYLSKIEDLQLVVNDKSQNLRRLQAQRNELNAKVRLLREELQLLQEQGSYV 68
Query: 343 GEVVNVMGKNKVLVKVHPEGKYVVXXXXXXXXXXXXPSTRVALRNDSYVLHLVLPSKVDP 164
GEVV M K KVLVKVHPEGK+VV P+ RVALRNDSY LH +LP+KVDP
Sbjct: 69 GEVVRAMDKKKVLVKVHPEGKFVVDVDKNIDINDVTPNCRVALRNDSYTLHKILPNKVDP 128
Query: 163 LVNLMKVEKVPDSTYDMIGGLDQQIKEIKEVIELPIKHPELFESLGIAQPKGVL 2
LV+LM VEKVPDSTY+MIGGLD+QIKEIKEVIELP+KHPE FE+LGIAQPKGVL
Sbjct: 129 LVSLMMVEKVPDSTYEMIGGLDKQIKEIKEVIELPVKHPEHFEALGIAQPKGVL 182
>sp|P41836|PRS8_SCHPO 26S protease regulatory subunit 8 homolog
OS=Schizosaccharomyces pombe GN=let1 PE=2 SV=1
Length = 403
Score = 224 bits (569), Expect = 6e-058
Identities = 112/170 (65%), Positives = 130/170 (76%)
Frame = -1
Query: 511 EGLRPYYLQHIHELQLQVRQKTHNLNRLEAQRNELNSRVRMLRXXXXXXXXPGSYVGEVV 332
E + YY Q I + +L + QKT NL RLEAQRN LN+RVR+LR PGSYVGEV+
Sbjct: 14 ENIVQYYTQKIQDAELAILQKTQNLRRLEAQRNGLNARVRLLREEIQLLQEPGSYVGEVI 73
Query: 331 NVMGKNKVLVKVHPEGKYVVXXXXXXXXXXXXPSTRVALRNDSYVLHLVLPSKVDPLVNL 152
MGKNKVLVKVHPEGKYVV P+ RVALRNDSY L +LP+KVDPLV+L
Sbjct: 74 KTMGKNKVLVKVHPEGKYVVDISPDIDIKEIKPNIRVALRNDSYQLIKILPNKVDPLVSL 133
Query: 151 MKVEKVPDSTYDMIGGLDQQIKEIKEVIELPIKHPELFESLGIAQPKGVL 2
M VEK+PDSTY+M+GGL++QIKEIKEVIELP+KHPELFESLGI QPKG+L
Sbjct: 134 MMVEKIPDSTYEMVGGLEKQIKEIKEVIELPVKHPELFESLGIPQPKGIL 183
>sp|Q25544|PRS8_NAEFO 26S protease regulatory subunit 8 homolog OS=Naegleria
fowleri PE=2 SV=1
Length = 414
Score = 222 bits (565), Expect = 2e-057
Identities = 109/169 (64%), Positives = 129/169 (76%)
Frame = -1
Query: 508 GLRPYYLQHIHELQLQVRQKTHNLNRLEAQRNELNSRVRMLRXXXXXXXXPGSYVGEVVN 329
GL+ YY+ I E ++ +R K NL RL+AQRNELN RVR L+ PGS+VGEVV
Sbjct: 26 GLKNYYIAKIQEKEIVLRDKIENLRRLQAQRNELNGRVRSLKEELQQLQEPGSHVGEVVK 85
Query: 328 VMGKNKVLVKVHPEGKYVVXXXXXXXXXXXXPSTRVALRNDSYVLHLVLPSKVDPLVNLM 149
VMGK KVL+K+ EGKY+V P RVALRNDSY LH +LP+K+DPLV+LM
Sbjct: 86 VMGKKKVLIKISQEGKYIVDIDKSIELKDLTPGVRVALRNDSYALHKILPNKIDPLVSLM 145
Query: 148 KVEKVPDSTYDMIGGLDQQIKEIKEVIELPIKHPELFESLGIAQPKGVL 2
KVEKVPD+TY+M+GGLD+QIKEIKEVIELPIKHPELFESLGIAQPKGV+
Sbjct: 146 KVEKVPDATYEMVGGLDEQIKEIKEVIELPIKHPELFESLGIAQPKGVI 194
>sp|Q01939|PRS8_YEAST 26S protease regulatory subunit 8 homolog OS=Saccharomyces
cerevisiae GN=RPT6 PE=1 SV=4
Length = 405
Score = 212 bits (539), Expect = 2e-054
Identities = 104/169 (61%), Positives = 126/169 (74%)
Frame = -1
Query: 508 GLRPYYLQHIHELQLQVRQKTHNLNRLEAQRNELNSRVRMLRXXXXXXXXPGSYVGEVVN 329
G++PY+ Q I E +L++R KT N+ RLEAQRN LN +VR ++ PGSYVGEV+
Sbjct: 18 GIKPYFEQKIQETELKIRSKTENVRRLEAQRNALNDKVRFIKDELRLLQEPGSYVGEVIK 77
Query: 328 VMGKNKVLVKVHPEGKYVVXXXXXXXXXXXXPSTRVALRNDSYVLHLVLPSKVDPLVNLM 149
++ KVLVKV PEGKY+V S RV LR+DSY+LH VL +K DPLV+LM
Sbjct: 78 IVSDKKVLVKVQPEGKYIVDVAKDINVKDLKASQRVCLRSDSYMLHKVLENKADPLVSLM 137
Query: 148 KVEKVPDSTYDMIGGLDQQIKEIKEVIELPIKHPELFESLGIAQPKGVL 2
VEKVPDSTYDM+GGL +QIKEIKEVIELP+KHPELFESLGIAQPKGV+
Sbjct: 138 MVEKVPDSTYDMVGGLTKQIKEIKEVIELPVKHPELFESLGIAQPKGVI 186
>sp|O26824|PSMR_METTH Proteasome-activating nucleotidase OS=Methanobacterium
thermoautotrophicum GN=pan PE=3 SV=1
Length = 410
Score = 108 bits (269), Expect = 4e-023
Identities = 57/157 (36%), Positives = 88/157 (56%)
Frame = -1
Query: 472 LQLQVRQKTHNLNRLEAQRNELNSRVRMLRXXXXXXXXPGSYVGEVVNVMGKNKVLVKVH 293
L ++R+ + +E +R L+ V+ LR P + V V+ ++V VK
Sbjct: 33 LMWKIRKLEKDKLLIENERTRLDREVKSLRGEIERFRTPPLVIATVTEVLDDHRVAVKST 92
Query: 292 PEGKYVVXXXXXXXXXXXXPSTRVALRNDSYVLHLVLPSKVDPLVNLMKVEKVPDSTYDM 113
+V+ P RVAL ++ + VLPS+ DP+V M+VE+ PD +Y+
Sbjct: 93 TGPHFVINYSRFIDRKQLEPGARVALNQQTFSIVDVLPSEKDPVVTGMEVEEKPDVSYEQ 152
Query: 112 IGGLDQQIKEIKEVIELPIKHPELFESLGIAQPKGVL 2
IGGL++Q++E+KE +ELP+K PELFE +GI PKGVL
Sbjct: 153 IGGLEEQVREVKETVELPLKKPELFEKIGIEPPKGVL 189
>sp|O28303|PSMR_ARCFU Proteasome-activating nucleotidase OS=Archaeoglobus
fulgidus GN=pan PE=3 SV=1
Length = 398
Score = 99 bits (244), Expect = 3e-020
Identities = 55/143 (38%), Positives = 78/143 (54%)
Frame = -1
Query: 430 LEAQRNELNSRVRMLRXXXXXXXXPGSYVGEVVNVMGKNKVLVKVHPEGKYVVXXXXXXX 251
+E++R VR LR P VG V +++ +V+VK K+VV
Sbjct: 37 IESERIRYEREVRRLRSEVERLRSPPLLVGVVSDILEDGRVVVKSSTGPKFVVNTSQYIN 96
Query: 250 XXXXXPSTRVALRNDSYVLHLVLPSKVDPLVNLMKVEKVPDSTYDMIGGLDQQIKEIKEV 71
P RVAL + + VLP+ DP+V +VE+ P+ +Y+ IGGLD QI+EI+E
Sbjct: 97 EEELKPGARVALNQQTLAIVNVLPTSKDPMVYGFEVEEKPEVSYEDIGGLDVQIEEIREA 156
Query: 70 IELPIKHPELFESLGIAQPKGVL 2
+ELP+ PELF +GI PKGVL
Sbjct: 157 VELPLLKPELFAEVGIEPPKGVL 179
>sp|Q8TX03|PSMR_METKA Proteasome-activating nucleotidase OS=Methanopyrus
kandleri GN=pan PE=3 SV=1
Length = 436
Score = 99 bits (244), Expect = 3e-020
Identities = 59/158 (37%), Positives = 84/158 (53%), Gaps = 2/158 (1%)
Frame = -1
Query: 475 ELQLQVRQKTHNLNRLEAQRNELNSRVRMLRXXXXXXXXPGSYVGEVVNVMGKNKVLVKV 296
E +L++ + R E +R E+ + LR P VG V ++ +V+VK
Sbjct: 62 EKELEMERDEKAELREELRRKEV--MIEKLRSDLQRMKKPPLIVGTVEEILDDGRVIVKS 119
Query: 295 HPEGKYVVXXXXXXXXXXXXPSTRVALRNDSYVLHLVLPSKVDPLVNLMKVEKVPDSTYD 116
K+V P VAL S + VLPS+ D V M+V++ PD +YD
Sbjct: 120 STGPKFVSNVSPTVDRNELEPGANVALNQQSMAVVDVLPSEKDSRVLAMEVDESPDVSYD 179
Query: 115 MIGGLDQQIKEIKEVIELPIKHPELFESLGIAQPKGVL 2
IGGLD+QI+EI+EV+E P+K PELFE +G+ PKGVL
Sbjct: 180 DIGGLDEQIREIREVVEKPLKEPELFEKVGVEPPKGVL 217
>sp|Q58576|PSMR_METJA Proteasome-activating nucleotidase OS=Methanocaldococcus
jannaschii GN=pan PE=1 SV=1
Length = 430
Score = 98 bits (242), Expect = 5e-020
Identities = 56/160 (35%), Positives = 85/160 (53%)
Frame = -1
Query: 481 IHELQLQVRQKTHNLNRLEAQRNELNSRVRMLRXXXXXXXXPGSYVGEVVNVMGKNKVLV 302
I EL+ ++ + LE + +L +LR P VG VV+ +G+ KV+V
Sbjct: 49 IAELESRILKLELEKKELERENLQLMKENEILRRELDRMRVPPLIVGTVVDKVGERKVVV 108
Query: 301 KVHPEGKYVVXXXXXXXXXXXXPSTRVALRNDSYVLHLVLPSKVDPLVNLMKVEKVPDST 122
K ++V P RV L + + VLP D M+V++ P+
Sbjct: 109 KSSTGPSFLVNVSHFVNPDDLAPGKRVCLNQQTLTVVDVLPENKDYRAKAMEVDERPNVR 168
Query: 121 YDMIGGLDQQIKEIKEVIELPIKHPELFESLGIAQPKGVL 2
Y+ IGGL++Q++EI+EV+ELP+KHPELFE +GI PKG+L
Sbjct: 169 YEDIGGLEKQMQEIREVVELPLKHPELFEKVGIEPPKGIL 208
>sp|A7I8B8|PSMR_METB6 Proteasome-activating nucleotidase OS=Methanoregula boonei
(strain 6A8) GN=pan PE=3 SV=1
Length = 436
Score = 96 bits (238), Expect = 1e-019
Identities = 54/158 (34%), Positives = 79/158 (50%)
Frame = -1
Query: 475 ELQLQVRQKTHNLNRLEAQRNELNSRVRMLRXXXXXXXXPGSYVGEVVNVMGKNKVLVKV 296
EL+ Q+RQ + +E Q+ VR L+ P +G VV+V+ N+V+V+
Sbjct: 59 ELREQIRQAEADKRYIETQKIRYEREVRKLKSESEQLRSPPLIIGTVVDVVDANRVIVRS 118
Query: 295 HPEGKYVVXXXXXXXXXXXXPSTRVALRNDSYVLHLVLPSKVDPLVNLMKVEKVPDSTYD 116
+++V P R L S + +LPS D V M++ P Y
Sbjct: 119 SAGPRFLVRSSPSVNPDDIKPGARCTLNQQSLAIVELLPSSFDAQVYGMELVDSPQECYT 178
Query: 115 MIGGLDQQIKEIKEVIELPIKHPELFESLGIAQPKGVL 2
IGGL +QI E++E +ELP+K PELF +GI PKGVL
Sbjct: 179 DIGGLKEQINEVREAVELPLKRPELFTQIGIEPPKGVL 216
>sp|O16368|PRS4_CAEEL Probable 26S protease regulatory subunit 4
OS=Caenorhabditis elegans GN=rpt-2 PE=2 SV=1
Length = 443
Score = 94 bits (233), Expect = 5e-019
Identities = 60/185 (32%), Positives = 89/185 (48%), Gaps = 15/185 (8%)
Frame = -1
Query: 556 PEDTCSAKLAASKLGEGLRPYYLQHIHELQLQVRQKTHNLNRLEAQRNELNSRVRMLRXX 377
P C KL S E ++ Y L +Q Q R K E ++ E ++V LR
Sbjct: 57 PHARCRLKLLKS---ERIKDYLLMEQEFIQNQERLKPQ-----EERQEEERAKVDELRGT 108
Query: 376 XXXXXXPGSYVGEVVNVMGKNKVLVKVHPEGKYVVXXXXXXXXXXXXPSTRVALRNDSYV 197
VG + ++ +V + ++ V P V L + ++
Sbjct: 109 PMA-------VGSLEEIIDDQHAIVSTNVGSEHYVNIMSFVDKEQLEPGCSVLLNHKNHA 161
Query: 196 LHLVLPSKVDPLVNLMKVEKVPDSTYDMIGGLDQQIKEIKEVIELPIKHPELFESLGIAQ 17
+ VL DP+V++MK+EK P TY +GGLDQQI+EIKE +ELP+ HPE +E +GI
Sbjct: 162 VIGVLSDDTDPMVSVMKLEKAPQETYADVGGLDQQIQEIKEAVELPLTHPEYYEEMGIRP 221
Query: 16 PKGVL 2
PKGV+
Sbjct: 222 PKGVI 226
>sp|A3CV35|PSMR_METMJ Proteasome-activating nucleotidase OS=Methanoculleus
marisnigri (strain ATCC 35101 / DSM 1498 / JR1) GN=pan PE=3 SV=1
Length = 412
Score = 94 bits (232), Expect = 7e-019
Identities = 51/158 (32%), Positives = 82/158 (51%)
Frame = -1
Query: 475 ELQLQVRQKTHNLNRLEAQRNELNSRVRMLRXXXXXXXXPGSYVGEVVNVMGKNKVLVKV 296
EL+ Q RQ +E Q+ +R L+ P +G V +V+ ++V+V+
Sbjct: 34 ELREQFRQMESEKRYVETQKIRYERELRKLKSEIEQLRSPPLVIGTVTDVIDNSRVIVRS 93
Query: 295 HPEGKYVVXXXXXXXXXXXXPSTRVALRNDSYVLHLVLPSKVDPLVNLMKVEKVPDSTYD 116
+++V P R L S + VLP+ D + M++ + P+ TY+
Sbjct: 94 SAGPRFLVRTSQLIDPDLLKPGVRCTLNQQSLAIVDVLPTSYDAQIYGMELVESPEETYE 153
Query: 115 MIGGLDQQIKEIKEVIELPIKHPELFESLGIAQPKGVL 2
IGGL+ QI+EI+E +ELP+ P+LFE +GI+ PKGVL
Sbjct: 154 NIGGLEPQIEEIREAVELPLTKPQLFEKVGISPPKGVL 191
>sp|Q90732|PRS4_CHICK 26S protease regulatory subunit 4 OS=Gallus gallus
GN=PSMC1 PE=2 SV=1
Length = 440
Score = 94 bits (231), Expect = 9e-019
Identities = 65/192 (33%), Positives = 91/192 (47%), Gaps = 15/192 (7%)
Frame = -1
Query: 577 TKPVEALPEDTCSAKLAASKLGEGLRPYYLQHIHELQLQVRQKTHNLNRLEAQRNELNSR 398
+KP P C KL KL E ++ Y L ++ Q + K LE ++ E S+
Sbjct: 47 SKPPLVTPHTQCRLKLL--KL-ERIKDYLLMEEEFIRNQEQMKP-----LEEKQEEERSK 98
Query: 397 VRMLRXXXXXXXXPGSYVGEVVNVMGKNKVLVKVHPEGKYVVXXXXXXXXXXXXPSTRVA 218
V LR VG + ++ N +V ++ V P V
Sbjct: 99 VDDLRGTPMS-------VGTLEEIIDDNHAIVSTSVGSEHYVSILSFVDKDLLEPGCSVL 151
Query: 217 LRNDSYVLHLVLPSKVDPLVNLMKVEKVPDSTYDMIGGLDQQIKEIKEVIELPIKHPELF 38
L + + + VL DPLV +MK+EK P TY IGGLD QI+EIKE +ELP+ HPE +
Sbjct: 152 LNHKVHAVIGVLMDDTDPLVTVMKLEKAPQETYADIGGLDNQIQEIKESVELPLTHPEYY 211
Query: 37 ESLGIAQPKGVL 2
E +GI PKGV+
Sbjct: 212 EEMGIKPPKGVI 223
>sp|P53549|PRS10_YEAST 26S protease subunit RPT4 OS=Saccharomyces cerevisiae
GN=RPT4 PE=1 SV=4
Length = 437
Score = 93 bits (229), Expect = 2e-018
Identities = 51/154 (33%), Positives = 84/154 (54%), Gaps = 7/154 (4%)
Frame = -1
Query: 463 QVRQKTHNLNRLEAQRNELNSRVRMLRXXXXXXXXPGSYVGEVVNVMGKNKVLVKVHPEG 284
Q++Q+ N+ LE ++ + ++ L+ G +GEV+ + + K +VK
Sbjct: 73 QLKQRRQNIRDLEKLYDKTENDIKALQSI-------GQLIGEVMKELSEEKYIVKASSGP 125
Query: 283 KYVVXXXXXXXXXXXXPSTRVALRNDSYVLHLVLPSKVDPLVNLMKVEKVPDSTYDMIGG 104
+Y+V RV L + + +LP + DPLV M + + T+D IGG
Sbjct: 126 RYIVGVRNSVDRSKLKKGVRVTLDITTLTIMRILPRETDPLVYNMTSFEQGEITFDGIGG 185
Query: 103 LDQQIKEIKEVIELPIKHPELFESLGIAQPKGVL 2
L +QI+E++EVIELP+K+PE+F+ +GI PKGVL
Sbjct: 186 LTEQIRELREVIELPLKNPEIFQRVGIKPPKGVL 219
>sp|Q2FQ56|PSMR_METHJ Proteasome-activating nucleotidase OS=Methanospirillum
hungatei (strain JF-1 / DSM 864) GN=pan PE=3 SV=1
Length = 412
Score = 93 bits (229), Expect = 2e-018
Identities = 52/158 (32%), Positives = 79/158 (50%)
Frame = -1
Query: 475 ELQLQVRQKTHNLNRLEAQRNELNSRVRMLRXXXXXXXXPGSYVGEVVNVMGKNKVLVKV 296
EL+ Q+RQ + +E Q+ VR L+ P VG + +++ +V+V+
Sbjct: 34 ELKEQIRQLESDKRYIETQKIRYEREVRKLKSEIEHLKTPPLIVGTITDIIDSGRVVVRS 93
Query: 295 HPEGKYVVXXXXXXXXXXXXPSTRVALRNDSYVLHLVLPSKVDPLVNLMKVEKVPDSTYD 116
+++V R L S + VLPS D V M++ P TY+
Sbjct: 94 SAGPRFLVRVSQAVNPTTLKAGVRCTLNQQSLAIVEVLPSTYDSQVYGMELVDAPTETYE 153
Query: 115 MIGGLDQQIKEIKEVIELPIKHPELFESLGIAQPKGVL 2
IGGL++QI EI+E +ELP+ P+LFE +GI PKGVL
Sbjct: 154 DIGGLEKQIMEIREAVELPMTRPDLFEKIGINPPKGVL 191
>sp|Q0W257|PSMR_UNCMA Proteasome-activating nucleotidase OS=Uncultured
methanogenic archaeon RC-I GN=pan PE=3 SV=1
Length = 417
Score = 92 bits (228), Expect = 2e-018
Identities = 51/143 (35%), Positives = 74/143 (51%)
Frame = -1
Query: 430 LEAQRNELNSRVRMLRXXXXXXXXPGSYVGEVVNVMGKNKVLVKVHPEGKYVVXXXXXXX 251
+E ++ + +R L P VG +++VM K+++K K+VV
Sbjct: 55 VENKKVQYEREIRKLTSELDRLKTPPLIVGTILDVMANGKMIIKSSTGPKFVVNSSQFIN 114
Query: 250 XXXXXPSTRVALRNDSYVLHLVLPSKVDPLVNLMKVEKVPDSTYDMIGGLDQQIKEIKEV 71
P +VAL S + VLP+ DP V M+V P+ Y IGGL+ QI E+KE
Sbjct: 115 SKEVYPGAKVALNQQSLAVIEVLPTVKDPSVLGMEVVDSPEIDYQSIGGLEAQINELKET 174
Query: 70 IELPIKHPELFESLGIAQPKGVL 2
+ELP+ PELF+ +GI PKGVL
Sbjct: 175 VELPLLKPELFQKVGIEPPKGVL 197
>sp|P62191|PRS4_HUMAN 26S protease regulatory subunit 4 OS=Homo sapiens GN=PSMC1
PE=1 SV=1
Length = 440
Score = 92 bits (227), Expect = 3e-018
Identities = 64/185 (34%), Positives = 88/185 (47%), Gaps = 15/185 (8%)
Frame = -1
Query: 556 PEDTCSAKLAASKLGEGLRPYYLQHIHELQLQVRQKTHNLNRLEAQRNELNSRVRMLRXX 377
P C KL KL E ++ Y L ++ Q + K LE ++ E S+V LR
Sbjct: 54 PHTQCRLKLL--KL-ERIKDYLLMEEEFIRNQEQMKP-----LEEKQEEERSKVDDLRGT 105
Query: 376 XXXXXXPGSYVGEVVNVMGKNKVLVKVHPEGKYVVXXXXXXXXXXXXPSTRVALRNDSYV 197
VG + ++ N +V ++ V P V L + +
Sbjct: 106 PMS-------VGTLEEIIDDNHAIVSTSVGSEHYVSILSFVDKDLLEPGCSVLLNHKVHA 158
Query: 196 LHLVLPSKVDPLVNLMKVEKVPDSTYDMIGGLDQQIKEIKEVIELPIKHPELFESLGIAQ 17
+ VL DPLV +MKVEK P TY IGGLD QI+EIKE +ELP+ HPE +E +GI
Sbjct: 159 VIGVLMDDTDPLVTVMKVEKAPQETYADIGGLDNQIQEIKESVELPLTHPEYYEEMGIKP 218
Query: 16 PKGVL 2
PKGV+
Sbjct: 219 PKGVI 223
>sp|P62192|PRS4_MOUSE 26S protease regulatory subunit 4 OS=Mus musculus GN=Psmc1
PE=1 SV=1
Length = 440
Score = 92 bits (227), Expect = 3e-018
Identities = 64/185 (34%), Positives = 88/185 (47%), Gaps = 15/185 (8%)
Frame = -1
Query: 556 PEDTCSAKLAASKLGEGLRPYYLQHIHELQLQVRQKTHNLNRLEAQRNELNSRVRMLRXX 377
P C KL KL E ++ Y L ++ Q + K LE ++ E S+V LR
Sbjct: 54 PHTQCRLKLL--KL-ERIKDYLLMEEEFIRNQEQMKP-----LEEKQEEERSKVDDLRGT 105
Query: 376 XXXXXXPGSYVGEVVNVMGKNKVLVKVHPEGKYVVXXXXXXXXXXXXPSTRVALRNDSYV 197
VG + ++ N +V ++ V P V L + +
Sbjct: 106 PMS-------VGTLEEIIDDNHAIVSTSVGSEHYVSILSFVDKDLLEPGCSVLLNHKVHA 158
Query: 196 LHLVLPSKVDPLVNLMKVEKVPDSTYDMIGGLDQQIKEIKEVIELPIKHPELFESLGIAQ 17
+ VL DPLV +MKVEK P TY IGGLD QI+EIKE +ELP+ HPE +E +GI
Sbjct: 159 VIGVLMDDTDPLVTVMKVEKAPQETYADIGGLDNQIQEIKESVELPLTHPEYYEEMGIKP 218
Query: 16 PKGVL 2
PKGV+
Sbjct: 219 PKGVI 223
>sp|P62193|PRS4_RAT 26S protease regulatory subunit 4 OS=Rattus norvegicus
GN=Psmc1 PE=2 SV=1
Length = 440
Score = 92 bits (227), Expect = 3e-018
Identities = 64/185 (34%), Positives = 88/185 (47%), Gaps = 15/185 (8%)
Frame = -1
Query: 556 PEDTCSAKLAASKLGEGLRPYYLQHIHELQLQVRQKTHNLNRLEAQRNELNSRVRMLRXX 377
P C KL KL E ++ Y L ++ Q + K LE ++ E S+V LR
Sbjct: 54 PHTQCRLKLL--KL-ERIKDYLLMEEEFIRNQEQMKP-----LEEKQEEERSKVDDLRGT 105
Query: 376 XXXXXXPGSYVGEVVNVMGKNKVLVKVHPEGKYVVXXXXXXXXXXXXPSTRVALRNDSYV 197
VG + ++ N +V ++ V P V L + +
Sbjct: 106 PMS-------VGTLEEIIDDNHAIVSTSVGSEHYVSILSFVDKDLLEPGCSVLLNHKVHA 158
Query: 196 LHLVLPSKVDPLVNLMKVEKVPDSTYDMIGGLDQQIKEIKEVIELPIKHPELFESLGIAQ 17
+ VL DPLV +MKVEK P TY IGGLD QI+EIKE +ELP+ HPE +E +GI
Sbjct: 159 VIGVLMDDTDPLVTVMKVEKAPQETYADIGGLDNQIQEIKESVELPLTHPEYYEEMGIKP 218
Query: 16 PKGVL 2
PKGV+
Sbjct: 219 PKGVI 223
>sp|Q980M1|PSMR_SULSO Proteasome-activating nucleotidase OS=Sulfolobus
solfataricus GN=pan PE=3 SV=1
Length = 393
Score = 91 bits (223), Expect = 8e-018
Identities = 52/158 (32%), Positives = 80/158 (50%), Gaps = 1/158 (0%)
Frame = -1
Query: 475 ELQLQVRQKTHNLNRLEAQRNELNSRVRMLRXXXXXXXXPGSYVGEVVNVMGKNKVLVKV 296
E+QL VR + L+ + L + + P V++V+ +VLV+
Sbjct: 16 EVQL-VRLLEEKIKSLQIEIENLRKELNYYKAEMEKMLSPPLIEAVVLDVLPDGRVLVRS 74
Query: 295 HPEGKYVVXXXXXXXXXXXXPSTRVALRNDSYVLHLVLPSKVDPLVNLMKVEKVPDSTYD 116
VV P VAL + VLP K DP+V M++ + P+ TY
Sbjct: 75 SSGPNLVVNIASHIDQKLIKPGISVALNQRGSTILEVLPQKEDPIVKTMEIIERPNVTYS 134
Query: 115 MIGGLDQQIKEIKEVIELPIKHPELFESLGIAQPKGVL 2
IGGL++QI+E++EV+ELP+K+PE+F +G+ PKGVL
Sbjct: 135 EIGGLEEQIRELREVVELPLKNPEIFREIGVEPPKGVL 172
>sp|Q5E9F9|PRS7_BOVIN 26S protease regulatory subunit 7 OS=Bos taurus GN=PSMC2
PE=2 SV=3
Length = 433
Score = 89 bits (220), Expect = 2e-017
Identities = 42/104 (40%), Positives = 62/104 (59%)
Frame = -1
Query: 313 KVLVKVHPEGKYVVXXXXXXXXXXXXPSTRVALRNDSYVLHLVLPSKVDPLVNLMKVEKV 134
K ++ V K+VV RV + + Y +H+ LP K+DP V +M+VE+
Sbjct: 110 KYIINVKQFAKFVVDLSDQVAPTDIEEGMRVGVDRNKYQIHIPLPPKIDPTVTMMQVEEK 169
Query: 133 PDSTYDMIGGLDQQIKEIKEVIELPIKHPELFESLGIAQPKGVL 2
PD TY +GG +QI++++EV+E P+ HPE F +LGI PKGVL
Sbjct: 170 PDVTYSDVGGCKEQIEKLREVVETPLLHPERFVNLGIEPPKGVL 213
>sp|P35998|PRS7_HUMAN 26S protease regulatory subunit 7 OS=Homo sapiens GN=PSMC2
PE=1 SV=3
Length = 433
Score = 89 bits (220), Expect = 2e-017
Identities = 42/104 (40%), Positives = 62/104 (59%)
Frame = -1
Query: 313 KVLVKVHPEGKYVVXXXXXXXXXXXXPSTRVALRNDSYVLHLVLPSKVDPLVNLMKVEKV 134
K ++ V K+VV RV + + Y +H+ LP K+DP V +M+VE+
Sbjct: 110 KYIINVKQFAKFVVDLSDQVAPTDIEEGMRVGVDRNKYQIHIPLPPKIDPTVTMMQVEEK 169
Query: 133 PDSTYDMIGGLDQQIKEIKEVIELPIKHPELFESLGIAQPKGVL 2
PD TY +GG +QI++++EV+E P+ HPE F +LGI PKGVL
Sbjct: 170 PDVTYSDVGGCKEQIEKLREVVETPLLHPERFVNLGIEPPKGVL 213
>sp|Q4R4R0|PRS7_MACFA 26S protease regulatory subunit 7 OS=Macaca fascicularis
GN=PSMC2 PE=2 SV=3
Length = 433
Score = 89 bits (220), Expect = 2e-017
Identities = 42/104 (40%), Positives = 62/104 (59%)
Frame = -1
Query: 313 KVLVKVHPEGKYVVXXXXXXXXXXXXPSTRVALRNDSYVLHLVLPSKVDPLVNLMKVEKV 134
K ++ V K+VV RV + + Y +H+ LP K+DP V +M+VE+
Sbjct: 110 KYIINVKQFAKFVVDLSDQVAPTDIEEGMRVGVDRNKYQIHIPLPPKIDPTVTMMQVEEK 169
Query: 133 PDSTYDMIGGLDQQIKEIKEVIELPIKHPELFESLGIAQPKGVL 2
PD TY +GG +QI++++EV+E P+ HPE F +LGI PKGVL
Sbjct: 170 PDVTYSDVGGCKEQIEKLREVVETPLLHPERFVNLGIEPPKGVL 213
Database: UniProt/Swiss-Prot
Posted date: Thu Apr 23 14:22:33 2009
Number of letters in database: 163,773,382
Number of sequences in database: 462,764
Lambda K H
0.267 0.041 0.140
Gapped
Lambda K H
0.267 0.041 0.140
Matrix: blosum62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 4,100,050,437
Number of Sequences: 462764
Number of Extensions: 4100050437
Number of Successful Extensions: 47778554
Number of sequences better than 0.0: 0
|