BLASTX 7.6.2
Query= RU04463 /QuerySize=1236
(1235 letters)
Database: UniProt/Swiss-Prot;
462,764 sequences; 163,773,382 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q8L9G7|APH1_ARATH Gamma-secretase subunit APH1-like OS=Arabid... 354 9e-097
sp|Q9VQG2|APH1_DROME Gamma-secretase subunit Aph-1 OS=Drosophila... 74 2e-012
sp|Q8C7N7|APH1B_MOUSE Gamma-secretase subunit APH-1B OS=Mus musc... 64 1e-009
sp|Q8WW43|APH1B_HUMAN Gamma-secretase subunit APH-1B OS=Homo sap... 63 3e-009
sp|Q8JHE9|APH1B_DANRE Gamma-secretase subunit Aph-1b OS=Danio re... 62 5e-009
sp|Q5RDM3|APH1B_PONAB Gamma-secretase subunit APH-1B OS=Pongo ab... 62 7e-009
sp|Q9DCZ9|APH1C_MOUSE Putative gamma-secretase subunit APH-1C OS... 61 2e-008
sp|Q55FS3|APH1_DICDI Gamma-secretase subunit Aph-1 OS=Dictyostel... 59 4e-008
>sp|Q8L9G7|APH1_ARATH Gamma-secretase subunit APH1-like OS=Arabidopsis thaliana
GN=At2g31440 PE=2 SV=2
Length = 250
Score = 354 bits (907), Expect = 9e-097
Identities = 165/224 (73%), Positives = 193/224 (86%)
Frame = -2
Query: 1129 ISVISKKPFXXXXXXXXXXXXXXXXIMLSGLWRPFLPLKSSAWWPYSLLIFTSVLFQEAL 950
+SVIS+KPF I+LSGLWRPFLPLK++ WWPY+LL+ TSV FQE L
Sbjct: 22 VSVISRKPFLILTVLSSTLLWLVSLIILSGLWRPFLPLKANVWWPYALLVITSVCFQEGL 81
Query: 949 RILFWKVYKKLEDTLDAFADRVSKPRLYLTDKMQIALAGGLGHGVAQAVFFCLSLLTPAF 770
R LFWKVYK+LED LD+FADR+S+PRL+LTDK+QIALAGGLGHGVA AVFFCLSLLTPAF
Sbjct: 82 RFLFWKVYKRLEDVLDSFADRISRPRLFLTDKLQIALAGGLGHGVAHAVFFCLSLLTPAF 141
Query: 769 GPGTFFVDRCSKIPFFLLSAIIALAFVTIHTFSMVIAFNGYAEGNKVDQIFVPLVHLVAG 590
GP TF+V+RCSK+PFFL+SAIIALAFVTIHTFSMVIAF GYA+GNKVDQI VP++HL AG
Sbjct: 142 GPATFYVERCSKVPFFLISAIIALAFVTIHTFSMVIAFEGYAKGNKVDQIIVPVIHLTAG 201
Query: 589 MVTLVNFASGGCIIGIPLLYFVAVLTLLHCGKMVWRRLTENRHR 458
M+TLVNFAS GC+IG+PLLY VA LTL+HCGKMVW+RL E+R++
Sbjct: 202 MLTLVNFASEGCVIGVPLLYLVASLTLVHCGKMVWQRLLESRNQ 245
>sp|Q9VQG2|APH1_DROME Gamma-secretase subunit Aph-1 OS=Drosophila melanogaster
GN=aph-1 PE=1 SV=1
Length = 238
Score = 74 bits (179), Expect = 2e-012
Identities = 57/191 (29%), Positives = 95/191 (49%), Gaps = 18/191 (9%)
Frame = -2
Query: 1054 IMLSGLWRPFLPLKSSAWWPYSLL---------IFTSVLFQEALRILFWKVYKKLEDTLD 902
I+++ + L L S+ W Y+L+ + SV FQEA R + +++ + E L
Sbjct: 34 ILIAAAFFWLLSLLISSLW-YALIPLKEFLAFGVVFSVCFQEAFRYIIYRILRSTEQGLH 92
Query: 901 AFADRVSKPRLYLTDKMQI-ALAGGLGHGVAQAVFFCLSLLTPAFGPGTFFVDRCSKIPF 725
A A+ +TD I A GLG G+ +F +++L GPGT + +++ F
Sbjct: 93 AVAEDTR-----VTDNKHILAYVSGLGFGIISGMFALVNVLADMSGPGTMGLKGGTEL-F 146
Query: 724 FLLSAIIALAFVTIHTFSMVIAFNGYAEGNKVDQIFVPLVHLVAGMVTLVNFASGGCIIG 545
F+ SA AL+ + +HTF VI FN + N + +V HL ++TL+N A+
Sbjct: 147 FVTSAAQALSIILLHTFWSVIFFNAFDTNNYIHIGYVVFSHLFVSLITLLN-ANELYTTT 205
Query: 544 IPLLYFVAVLT 512
+ + Y V +LT
Sbjct: 206 LLINYLVTILT 216
>sp|Q8C7N7|APH1B_MOUSE Gamma-secretase subunit APH-1B OS=Mus musculus GN=Aph1b
PE=2 SV=1
Length = 257
Score = 64 bits (155), Expect = 1e-009
Identities = 50/161 (31%), Positives = 76/161 (47%), Gaps = 12/161 (7%)
Frame = -2
Query: 988 LLIF---TSVLFQEALRILFWKVYKKLEDTLDAFADRVSKPRLYLTDKMQIALAGGLGHG 818
LLIF SV QE R+ ++K+ KK + L + + P + L +A GLG G
Sbjct: 71 LLIFGVLLSVCIQELFRLAYYKLLKKASEGLKSINPEETAPSMRL-----LAYVSGLGFG 125
Query: 817 VAQAVFFCLSLLTPAFGPGTFFVDRCSKIPFFLLSAIIALAFVTIHTFSMVIAFNGYAEG 638
+ VF ++ L+ + GPGT + S FFL SA + L + +H F V+ F+G +
Sbjct: 126 IMSGVFSFVNTLSNSLGPGTVGIHGDSP-QFFLNSAFMTLVVIMLHVFWGVVFFDGCEKN 184
Query: 637 NKVDQIFVPLVHLVAGMVTLVNFASGGCIIGIPLLYFVAVL 515
+ V L HLV V+ F S + + Y + VL
Sbjct: 185 KWYTLLTVLLTHLV---VSTQTFLSPYYEVNLVTAYIIMVL 222
>sp|Q8WW43|APH1B_HUMAN Gamma-secretase subunit APH-1B OS=Homo sapiens GN=APH1B
PE=1 SV=3
Length = 257
Score = 63 bits (152), Expect = 3e-009
Identities = 44/155 (28%), Positives = 72/155 (46%), Gaps = 9/155 (5%)
Frame = -2
Query: 979 FTSVLFQEALRILFWKVYKKLEDTLDAFADRVSKPRLYLTDKMQIALAGGLGHGVAQAVF 800
F SV QE R ++K+ KK + L + + P + L +A GLG G+ VF
Sbjct: 77 FVSVYIQEMFRFAYYKLLKKASEGLKSINPGETAPSMRL-----LAYVSGLGFGIMSGVF 131
Query: 799 FCLSLLTPAFGPGTFFVDRCSKIPFFLLSAIIALAFVTIHTFSMVIAFNGYAEGNKVDQI 620
++ L+ + GPGT + S FFL SA + L + +H F ++ F+G + +
Sbjct: 132 SFVNTLSDSLGPGTVGIHGDSP-QFFLYSAFMTLVIILLHVFWGIVFFDGCEKKKWGILL 190
Query: 619 FVPLVHLVAGMVTLVNFASGGCIIGIPLLYFVAVL 515
V L HL+ T ++ G I + + + VL
Sbjct: 191 IVLLTHLLVSAQTFISSYYG---INLASAFIILVL 222
>sp|Q8JHE9|APH1B_DANRE Gamma-secretase subunit Aph-1b OS=Danio rerio GN=aph1b
PE=2 SV=1
Length = 258
Score = 62 bits (150), Expect = 5e-009
Identities = 52/175 (29%), Positives = 79/175 (45%), Gaps = 8/175 (4%)
Frame = -2
Query: 1015 KSSAWWPYSLLIF---TSVLFQEALRILFWKVYKKLEDTLDAFADRVSKPRLYLTDKMQI 845
K+SA LLIF SVL QEA R ++++ KK + L A + + P Q+
Sbjct: 62 KNSATQQRGLLIFGVVLSVLLQEAFRYGYYRLLKKANEGLLALSQEDTMP----ISMRQL 117
Query: 844 ALAGGLGHGVAQAVFFCLSLLTPAFGPGTFFVDRCSKIPFFLLSAIIALAFVTIHTFSMV 665
A GLG G F +++L+ + GPGT + S+ +F+ SA + LA + +H F V
Sbjct: 118 AYVSGLGFGFMSGAFSVVNILSDSLGPGTVGIHGESQ-HYFISSAFMTLAIILLHMFWGV 176
Query: 664 IAFNGYAEGNKVDQIFVPLVHLVAGMVTLVNFASGGCIIGIPLLYFVAVLTLLHC 500
+ F V HLV +T VN G +I ++ V + C
Sbjct: 177 VFFEACERQRWWALGAVVASHLVVSCLTFVNPHYQGSLIPTYIILSVMAVWAYLC 231
>sp|Q5RDM3|APH1B_PONAB Gamma-secretase subunit APH-1B OS=Pongo abelii GN=APH1B
PE=2 SV=1
Length = 257
Score = 62 bits (149), Expect = 7e-009
Identities = 43/155 (27%), Positives = 72/155 (46%), Gaps = 9/155 (5%)
Frame = -2
Query: 979 FTSVLFQEALRILFWKVYKKLEDTLDAFADRVSKPRLYLTDKMQIALAGGLGHGVAQAVF 800
F SV QE R ++++ KK + L + + P + L +A GLG G+ VF
Sbjct: 77 FVSVYIQEMFRFAYYRLLKKASEGLKSINPGETAPSMRL-----LAYVSGLGFGIMSGVF 131
Query: 799 FCLSLLTPAFGPGTFFVDRCSKIPFFLLSAIIALAFVTIHTFSMVIAFNGYAEGNKVDQI 620
++ L+ + GPGT + S FFL SA + L + +H F ++ F+G + +
Sbjct: 132 SFVNTLSDSLGPGTVGIHGDSP-QFFLYSAFMTLVIILLHVFWGIVFFDGCEKKKWGILL 190
Query: 619 FVPLVHLVAGMVTLVNFASGGCIIGIPLLYFVAVL 515
V L HL+ T ++ G I + + + VL
Sbjct: 191 IVLLTHLLVSAQTFISSYYG---INLASAFIILVL 222
>sp|Q9DCZ9|APH1C_MOUSE Putative gamma-secretase subunit APH-1C OS=Mus musculus
GN=Aph1c PE=2 SV=1
Length = 258
Score = 61 bits (146), Expect = 2e-008
Identities = 50/162 (30%), Positives = 76/162 (46%), Gaps = 13/162 (8%)
Frame = -2
Query: 988 LLIF---TSVLFQEALRILFWKVYKKLEDTLDAFADRVSKPRLYLTDKMQ-IALAGGLGH 821
LLIF SV QE R+ ++K+ KK + L + P + M+ +A GLG
Sbjct: 71 LLIFGALLSVCIQELFRLAYYKLLKKASEGLKSI-----NPEEDIAPSMRLLAYVSGLGF 125
Query: 820 GVAQAVFFCLSLLTPAFGPGTFFVDRCSKIPFFLLSAIIALAFVTIHTFSMVIAFNGYAE 641
G+ VF ++ L+ + GPGT + S FFL SA + L + +H F V+ F+G +
Sbjct: 126 GIMSGVFSFVNTLSNSLGPGTVGIHGDSP-QFFLNSAFMTLVVIMLHVFWGVVFFDGCEK 184
Query: 640 GNKVDQIFVPLVHLVAGMVTLVNFASGGCIIGIPLLYFVAVL 515
+ V L HLV V+ F S + + Y + VL
Sbjct: 185 NKWYTLLTVLLTHLV---VSTQTFLSPYYEVNLVTAYIIMVL 223
>sp|Q55FS3|APH1_DICDI Gamma-secretase subunit Aph-1 OS=Dictyostelium discoideum
GN=aph1 PE=3 SV=1
Length = 328
Score = 59 bits (142), Expect = 4e-008
Identities = 36/113 (31%), Positives = 53/113 (46%), Gaps = 2/113 (1%)
Frame = -2
Query: 832 GLGHGVAQAVFFCLSLLTPAFGPGTFFVDRCSKIPFFLLSAIIALAFVTIHTFSMVIAFN 653
G+G GVA S+L + GPGT F C + F+LS+II L +H V+AF
Sbjct: 202 GVGSGVAYGFIMFGSILWESTGPGTLFSPACPSVNLFMLSSIITLFMTLLHVVYNVLAFQ 261
Query: 652 GYAEGNKVDQIFVPLVHLVAGMVTLVNF--ASGGCIIGIPLLYFVAVLTLLHC 500
GY FV + H V +TL+N + C+ I + + V ++ C
Sbjct: 262 GYRSKKYHLVAFVIITHFVTTYLTLLNLPTKTTSCVGSILPIGIITVFSVGFC 314
Database: UniProt/Swiss-Prot
Posted date: Thu Apr 23 14:22:33 2009
Number of letters in database: 163,773,382
Number of sequences in database: 462,764
Lambda K H
0.267 0.041 0.140
Gapped
Lambda K H
0.267 0.041 0.140
Matrix: blosum62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 6,423,807,684
Number of Sequences: 462764
Number of Extensions: 6423807684
Number of Successful Extensions: 63594173
Number of sequences better than 0.0: 0
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