BLASTX 7.6.2
Query= RU05049 /QuerySize=1160
(1159 letters)
Database: UniProt/Swiss-Prot;
462,764 sequences; 163,773,382 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q9P6P9|PDK_SCHPO [Pyruvate dehydrogenase [lipoamide]] kinase,... 220 2e-056
sp|P91622|PDK_DROME [Pyruvate dehydrogenase [lipoamide]] kinase,... 185 5e-046
sp|Q15119|PDK2_HUMAN [Pyruvate dehydrogenase [lipoamide]] kinase... 179 3e-044
sp|Q9JK42|PDK2_MOUSE [Pyruvate dehydrogenase [lipoamide]] kinase... 179 3e-044
sp|Q64536|PDK2_RAT [Pyruvate dehydrogenase [lipoamide]] kinase i... 179 4e-044
sp|Q15120|PDK3_HUMAN [Pyruvate dehydrogenase [lipoamide]] kinase... 171 1e-041
sp|Q16654|PDK4_HUMAN [Pyruvate dehydrogenase [lipoamide]] kinase... 169 4e-041
sp|Q922H2|PDK3_MOUSE [Pyruvate dehydrogenase [lipoamide]] kinase... 168 6e-041
sp|O88345|PDK4_SPETR [Pyruvate dehydrogenase [lipoamide]] kinase... 168 6e-041
sp|O02623|PDK_ASCSU [Pyruvate dehydrogenase [lipoamide]] kinase,... 167 1e-040
sp|Q1KMR4|PDK4_RHIFE [Pyruvate dehydrogenase [lipoamide]] kinase... 164 9e-040
sp|O70571|PDK4_MOUSE [Pyruvate dehydrogenase [lipoamide]] kinase... 163 2e-039
sp|O54937|PDK4_RAT [Pyruvate dehydrogenase [lipoamide]] kinase i... 161 1e-038
sp|Q02332|PDK_CAEEL Probable [pyruvate dehydrogenase [lipoamide]... 156 4e-037
sp|Q8BFP9|PDK1_MOUSE [Pyruvate dehydrogenase [lipoamide]] kinase... 149 3e-035
sp|Q15118|PDK1_HUMAN [Pyruvate dehydrogenase [lipoamide]] kinase... 148 7e-035
sp|Q63065|PDK1_RAT [Pyruvate dehydrogenase [lipoamide]] kinase i... 148 9e-035
sp|Q2KJG8|BCKD_BOVIN [3-methyl-2-oxobutanoate dehydrogenase [lip... 114 1e-024
sp|O14874|BCKD_HUMAN [3-methyl-2-oxobutanoate dehydrogenase [lip... 114 1e-024
sp|Q00972|BCKD_RAT [3-methyl-2-oxobutanoate dehydrogenase [lipoa... 114 1e-024
sp|O55028|BCKD_MOUSE [3-methyl-2-oxobutanoate dehydrogenase [lip... 112 4e-024
>sp|Q9P6P9|PDK_SCHPO [Pyruvate dehydrogenase [lipoamide]] kinase, mitochondrial
OS=Schizosaccharomyces pombe GN=SPAC644.11c PE=2 SV=1
Length = 425
Score = 220 bits (558), Expect = 2e-056
Identities = 116/225 (51%), Positives = 161/225 (71%), Gaps = 6/225 (2%)
Frame = -2
Query: 1137 DEIHQFLDRFYMSRIGIRMLIGQHVELHNPNPPPHCVGYIHTKMSPLEVARNASEDARSI 958
+ I FLDRFYMSRIGIRML+GQ++ L + P + VG I T+ + ++ A+E+A+ I
Sbjct: 201 NSIQIFLDRFYMSRIGIRMLLGQYIALVSEPPRENYVGVISTRANIYQIIEGAAENAKYI 260
Query: 957 CFHEYG--SAPNVNIYGDPDFTFPYVPTHLHLMVFELVKNSLRA-VQERFMDSDKVAPPI 787
C YG AP + I DP YV +HL+ VFE++KNSLRA V+ +DSD PPI
Sbjct: 261 CRLAYGLFEAPEIQIICDPSLEMMYVESHLNHAVFEILKNSLRATVEFHGVDSD-FFPPI 319
Query: 786 RIIVADGIEDVTIKVSDEGGGIPRSGLPKIFTYLYSTAA-NHVDEQTDLGTTDSVT-MAG 613
++IVA G ED+TIK+SDEGGGI R +P +++Y+++TA+ D+ D+ + +S T MAG
Sbjct: 320 KVIVAKGQEDITIKISDEGGGISRRNIPLVWSYMFTTASPTLTDDPHDIVSANSTTPMAG 379
Query: 612 YGYGLPISRLYARYFGGDLQIISMEGYGTDAYLHLSRLGDSQEPL 478
+G+GLP++RLY RYFGGDL++ISMEGYGTD Y+HL+RL +S EPL
Sbjct: 380 FGFGLPLARLYTRYFGGDLELISMEGYGTDVYIHLNRLCESAEPL 424
>sp|P91622|PDK_DROME [Pyruvate dehydrogenase [lipoamide]] kinase, mitochondrial
OS=Drosophila melanogaster GN=Pdk PE=2 SV=2
Length = 413
Score = 185 bits (469), Expect = 5e-046
Identities = 105/228 (46%), Positives = 142/228 (62%), Gaps = 15/228 (6%)
Frame = -2
Query: 1131 IHQFLDRFYMSRIGIRMLIGQHVELH--NPNPPPHCVGYIHTKMSPLEVARNASEDARSI 958
I FLDR YMSRI IRMLI QH L NP+ +G + +V R+A E+AR +
Sbjct: 153 IQYFLDRLYMSRISIRMLINQHTLLFGGNPHAGGRHIGCLDPACDLSDVVRDAYENARFL 212
Query: 957 CFHEYGSAPNVNIY---GDPDFTFP----YVPTHLHLMVFELVKNSLRAVQERF-MDSDK 802
C Y ++P + I +P P YVP+HL+ M+FEL KNS+RAV E D++
Sbjct: 213 CDQYYLTSPALEIQQHSSEPGDNLPIRTVYVPSHLYYMLFELFKNSMRAVVEHHGHDNND 272
Query: 801 VAPPIRIIVADGIEDVTIKVSDEGGGIPRSGLPKIFTYLYSTAANHVDEQTDLGTTDSVT 622
PP+++ + G ED+ +K+SD+GGGIPRS ++F Y+YSTA ++DL T V
Sbjct: 273 TLPPLKVAICKGKEDICVKISDQGGGIPRSQTDQLFKYMYSTAPQ--PSKSDLHT---VP 327
Query: 621 MAGYGYGLPISRLYARYFGGDLQIISMEGYGTDAYLHLSRLGDSQEPL 478
+AGYGYGLPISRLYARYF GD+ ++S EG+GTDA ++L L D L
Sbjct: 328 LAGYGYGLPISRLYARYFHGDIVLLSCEGFGTDAIIYLKALSDEANEL 375
>sp|Q15119|PDK2_HUMAN [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 2,
mitochondrial OS=Homo sapiens GN=PDK2 PE=1 SV=2
Length = 407
Score = 179 bits (454), Expect = 3e-044
Identities = 104/230 (45%), Positives = 143/230 (62%), Gaps = 19/230 (8%)
Frame = -2
Query: 1131 IHQFLDRFYMSRIGIRMLIGQHVELH----NPNPPPHCVGYIHTKMSPLEVARNASEDAR 964
I FLDRFY+SRI IRMLI QH + NP P H +G I + EV ++A + A+
Sbjct: 151 IQYFLDRFYLSRISIRMLINQHTLIFDGSTNPAHPKH-IGSIDPNCNVSEVVKDAYDMAK 209
Query: 963 SICFHEYGSAPNVNIY------GDPDFTFPYVPTHLHLMVFELVKNSLRAVQERFMDSDK 802
+C Y ++P++ I YVP+HL+ M+FEL KN++RA E +S
Sbjct: 210 LLCDKYYMASPDLEIQEINAANSKQPIHMVYVPSHLYHMLFELFKNAMRATVESH-ESSL 268
Query: 801 VAPPIRIIVADGIEDVTIKVSDEGGGIPRSGLPKIFTYLYSTAANHVDEQTDLGTTDSVT 622
+ PPI+++VA G ED++IK+SD GGG+P + ++F+Y+YSTA T T
Sbjct: 269 ILPPIKVMVALGEEDLSIKMSDRGGGVPLRKIERLFSYMYSTA------PTPQPGTGGTP 322
Query: 621 MAGYGYGLPISRLYARYFGGDLQIISMEGYGTDAYLHLSRLG-DSQEPLP 475
+AG+GYGLPISRLYA+YF GDLQ+ SMEG+GTDA ++L L DS E LP
Sbjct: 323 LAGFGYGLPISRLYAKYFQGDLQLFSMEGFGTDAVIYLKALSTDSVERLP 372
>sp|Q9JK42|PDK2_MOUSE [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 2,
mitochondrial OS=Mus musculus GN=Pdk2 PE=1 SV=1
Length = 407
Score = 179 bits (454), Expect = 3e-044
Identities = 105/230 (45%), Positives = 143/230 (62%), Gaps = 19/230 (8%)
Frame = -2
Query: 1131 IHQFLDRFYMSRIGIRMLIGQHVELH----NPNPPPHCVGYIHTKMSPLEVARNASEDAR 964
I FLDRFY+SRI IRMLI QH + NP P H +G I S +V ++A + A+
Sbjct: 151 IQYFLDRFYLSRISIRMLINQHTLIFDGSTNPAHPKH-IGSIDPNCSVSDVVKDAYDMAK 209
Query: 963 SICFHEYGSAPNVNIY------GDPDFTFPYVPTHLHLMVFELVKNSLRAVQERFMDSDK 802
+C Y ++P++ I + YVP+HL+ M+FEL KN++RA E +S
Sbjct: 210 LLCDKYYMASPDLEIQEVNATNANQPIHMVYVPSHLYHMLFELFKNAMRATVESH-ESSL 268
Query: 801 VAPPIRIIVADGIEDVTIKVSDEGGGIPRSGLPKIFTYLYSTAANHVDEQTDLGTTDSVT 622
PPI+I+VA G ED++IK+SD GGG+P + ++F+Y+YSTA T T
Sbjct: 269 TLPPIKIMVALGEEDLSIKMSDRGGGVPLRRIERLFSYMYSTA------PTPQPGTGGTP 322
Query: 621 MAGYGYGLPISRLYARYFGGDLQIISMEGYGTDAYLHLSRLG-DSQEPLP 475
+AG+GYGLPISRLYA+YF GDLQ+ SMEG+GTDA ++L L DS E LP
Sbjct: 323 LAGFGYGLPISRLYAKYFQGDLQLFSMEGFGTDAVIYLKALSTDSVERLP 372
>sp|Q64536|PDK2_RAT [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 2,
mitochondrial OS=Rattus norvegicus GN=Pdk2 PE=1 SV=1
Length = 407
Score = 179 bits (453), Expect = 4e-044
Identities = 107/230 (46%), Positives = 145/230 (63%), Gaps = 19/230 (8%)
Frame = -2
Query: 1131 IHQFLDRFYMSRIGIRMLIGQHVELH----NPNPPPHCVGYIHTKMSPLEVARNASEDAR 964
I FLDRFY+SRI IRMLI QH + NP P H +G I S +V ++A + A+
Sbjct: 151 IQYFLDRFYLSRISIRMLINQHTLIFDGSTNPAHPKH-IGSIDPNCSVSDVVKDAYDMAK 209
Query: 963 SICFHEYGSAPNVNI--YGDPDFTFP----YVPTHLHLMVFELVKNSLRAVQERFMDSDK 802
+C Y ++P++ I + T P YVP+HL+ M+FEL KN++RA E +S
Sbjct: 210 LLCDKYYMASPDLEIQEVNATNATQPIHMVYVPSHLYHMLFELFKNAMRATVESH-ESSL 268
Query: 801 VAPPIRIIVADGIEDVTIKVSDEGGGIPRSGLPKIFTYLYSTAANHVDEQTDLGTTDSVT 622
PPI+I+VA G ED++IK+SD GGG+P + ++F+Y+YSTA T T
Sbjct: 269 TLPPIKIMVALGEEDLSIKMSDRGGGVPLRKIERLFSYMYSTA------PTPQPGTGGTP 322
Query: 621 MAGYGYGLPISRLYARYFGGDLQIISMEGYGTDAYLHLSRLG-DSQEPLP 475
+AG+GYGLPISRLYA+YF GDLQ+ SMEG+GTDA ++L L DS E LP
Sbjct: 323 LAGFGYGLPISRLYAKYFQGDLQLFSMEGFGTDAVIYLKALSTDSVERLP 372
>sp|Q15120|PDK3_HUMAN [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 3,
mitochondrial OS=Homo sapiens GN=PDK3 PE=1 SV=1
Length = 406
Score = 171 bits (432), Expect = 1e-041
Identities = 101/230 (43%), Positives = 136/230 (59%), Gaps = 17/230 (7%)
Frame = -2
Query: 1131 IHQFLDRFYMSRIGIRMLIGQHVELH----NPNPPPHCVGYIHTKMSPLEVARNASEDAR 964
I FLDRFY +RI RMLI QH L NP P H +G I + +V ++A E A+
Sbjct: 147 IQYFLDRFYTNRISFRMLINQHTLLFGGDTNPVHPKH-IGSIDPTCNVADVVKDAYETAK 205
Query: 963 SICFHEYGSAPNVNI------YGDPDFTFPYVPTHLHLMVFELVKNSLRAVQERFMDSDK 802
+C Y AP + + D YVP+HL M+FEL KNS+RA E + D +
Sbjct: 206 MLCEQYYLVAPELEVEEFNAKAPDKPIQVVYVPSHLFHMLFELFKNSMRATVELYEDRKE 265
Query: 801 VAPPIRIIVADGIEDVTIKVSDEGGGIPRSGLPKIFTYLYSTAANHVDEQTDLGTTDSVT 622
P ++ +V G ED++IK+SD GGG+P + ++F Y+YSTA + L T +
Sbjct: 266 GYPAVKTLVTLGKEDLSIKISDLGGGVPLRKIDRLFNYMYSTA-----PRPSLEPTRAAP 320
Query: 621 MAGYGYGLPISRLYARYFGGDLQIISMEGYGTDAYLHLSRL-GDSQEPLP 475
+AG+GYGLPISRLYARYF GDL++ SMEG GTDA ++L L +S E LP
Sbjct: 321 LAGFGYGLPISRLYARYFQGDLKLYSMEGVGTDAVIYLKALSSESFERLP 370
>sp|Q16654|PDK4_HUMAN [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 4,
mitochondrial OS=Homo sapiens GN=PDK4 PE=1 SV=1
Length = 411
Score = 169 bits (427), Expect = 4e-041
Identities = 95/228 (41%), Positives = 137/228 (60%), Gaps = 15/228 (6%)
Frame = -2
Query: 1131 IHQFLDRFYMSRIGIRMLIGQHVELHNPNPP--PHCVGYIHTKMSPLEVARNASEDARSI 958
+ FLDRFYM+RI RML+ QH+ + + + P +G I + V ++A E +R +
Sbjct: 155 LQYFLDRFYMNRISTRMLMNQHILIFSDSQTGNPSHIGSIDPNCDVVAVVQDAFECSRML 214
Query: 957 CFHEYGSAPNVNI------YGDPDFTFPYVPTHLHLMVFELVKNSLRAVQERFMDSDKVA 796
C Y S+P + + + D YVP+HLH M+FEL KN++RA E ++
Sbjct: 215 CDQYYLSSPELKLTQVNGKFPDQPIHIVYVPSHLHHMLFELFKNAMRATVEH-QENQPSL 273
Query: 795 PPIRIIVADGIEDVTIKVSDEGGGIPRSGLPKIFTYLYSTAANHVDEQTDLGTTDSVTMA 616
PI +IV G ED+TIK+SD GGG+P + ++F+Y YSTA V + + + +A
Sbjct: 274 TPIEVIVVLGKEDLTIKISDRGGGVPLRIIDRLFSYTYSTAPTPV-----MDNSRNAPLA 328
Query: 615 GYGYGLPISRLYARYFGGDLQIISMEGYGTDAYLHLSRL-GDSQEPLP 475
G+GYGLPISRLYA+YF GDL + S+ GYGTDA ++L L +S E LP
Sbjct: 329 GFGYGLPISRLYAKYFQGDLNLYSLSGYGTDAIIYLKALSSESIEKLP 376
>sp|Q922H2|PDK3_MOUSE [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 3,
mitochondrial OS=Mus musculus GN=Pdk3 PE=2 SV=1
Length = 415
Score = 168 bits (425), Expect = 6e-041
Identities = 100/230 (43%), Positives = 135/230 (58%), Gaps = 17/230 (7%)
Frame = -2
Query: 1131 IHQFLDRFYMSRIGIRMLIGQHVELH----NPNPPPHCVGYIHTKMSPLEVARNASEDAR 964
I FLDRFY +RI RMLI QH L NP P H +G I + +V ++A E A+
Sbjct: 147 IQYFLDRFYTNRISFRMLINQHTLLFGGDTNPAHPKH-IGSIDPTCNVADVVKDAYETAK 205
Query: 963 SICFHEYGSAPNVNI------YGDPDFTFPYVPTHLHLMVFELVKNSLRAVQERFMDSDK 802
+C Y AP + + + YVP+HL M+FEL KNS+RA E D +
Sbjct: 206 MLCEQYYLVAPELEVEEFNAKAPNKPIQVVYVPSHLFHMLFELFKNSMRATVELHEDKKE 265
Query: 801 VAPPIRIIVADGIEDVTIKVSDEGGGIPRSGLPKIFTYLYSTAANHVDEQTDLGTTDSVT 622
P ++ +V G ED++IK+SD GGG+P + ++F Y+YSTA + L T +
Sbjct: 266 GYPAVKTLVTLGKEDLSIKISDLGGGVPLRKIDRLFNYMYSTA-----PRPSLEPTRAAP 320
Query: 621 MAGYGYGLPISRLYARYFGGDLQIISMEGYGTDAYLHLSRL-GDSQEPLP 475
+AG+GYGLPISRLYARYF GDL++ SMEG GTDA ++L L +S E LP
Sbjct: 321 LAGFGYGLPISRLYARYFQGDLKLYSMEGVGTDAVIYLKALSSESFERLP 370
>sp|O88345|PDK4_SPETR [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 4,
mitochondrial OS=Spermophilus tridecemlineatus GN=PDK4 PE=2 SV=1
Length = 412
Score = 168 bits (425), Expect = 6e-041
Identities = 94/228 (41%), Positives = 138/228 (60%), Gaps = 15/228 (6%)
Frame = -2
Query: 1131 IHQFLDRFYMSRIGIRMLIGQHVELHNPNPP--PHCVGYIHTKMSPLEVARNASEDARSI 958
+ FLDRFYM+RI RML+ QH+ + + + P +G I K + V ++A E ++ +
Sbjct: 155 LQYFLDRFYMNRISTRMLMNQHILIFSDSQTGNPSHIGSIDPKCDVVAVIQDAFESSKML 214
Query: 957 CFHEYGSAPNVNI------YGDPDFTFPYVPTHLHLMVFELVKNSLRAVQERFMDSDKVA 796
C Y ++P + + + YVP+HLH M+FEL KN++RA ER +S
Sbjct: 215 CDQYYLTSPELKLTQVNGKFPGQPIHIVYVPSHLHHMLFELFKNAMRATVER-QESWPSL 273
Query: 795 PPIRIIVADGIEDVTIKVSDEGGGIPRSGLPKIFTYLYSTAANHVDEQTDLGTTDSVTMA 616
P+ +IV G ED+TIK+SD GGG+P ++F+Y+YSTA V + + + +A
Sbjct: 274 TPVEVIVVLGKEDLTIKISDRGGGVPLRITDRLFSYMYSTAPTPV-----MDNSRNAPLA 328
Query: 615 GYGYGLPISRLYARYFGGDLQIISMEGYGTDAYLHLSRL-GDSQEPLP 475
G+GYGLPISRLYA+YF GDL + S+ GYGTDA ++L L +S E LP
Sbjct: 329 GFGYGLPISRLYAKYFQGDLNLYSLSGYGTDAIIYLKALSSESVEKLP 376
>sp|O02623|PDK_ASCSU [Pyruvate dehydrogenase [lipoamide]] kinase, mitochondrial
OS=Ascaris suum PE=2 SV=1
Length = 399
Score = 167 bits (422), Expect = 1e-040
Identities = 100/230 (43%), Positives = 140/230 (60%), Gaps = 20/230 (8%)
Frame = -2
Query: 1131 IHQFLDRFYMSRIGIRMLIGQHVELHN---PNPPPHCVGYIHTKMSPLEVARNASEDARS 961
I FLDRFY++RI IRML QH+ + P P H +G I V +A E+AR
Sbjct: 148 IQYFLDRFYINRISIRMLQNQHLVVFGVVLPESPRH-IGCIDPGCDVESVVHDAYENARF 206
Query: 960 ICFHEYGSAPNVNIY-------GDPDFTFPYVPTHLHLMVFELVKNSLRAVQERFMDSDK 802
+C Y +AP + + G P + VP+HL+ ++FEL KNS+RA E +D+
Sbjct: 207 LCERYYLTAPGMKLEMHNSVNPGMP-ISIVAVPSHLYHIMFELFKNSMRATVENH-GADE 264
Query: 801 VAPPIRIIVADGIEDVTIKVSDEGGGIPRSGLPKIFTYLYSTAANHVDEQTDLGTTDSVT 622
PPI+++V G ED++IK+SD GGG+ R+ L ++FTY+YSTA + T
Sbjct: 265 DLPPIKVMVVRGAEDLSIKISDRGGGVSRTILDRLFTYMYSTAPPPPRDGT------QPP 318
Query: 621 MAGYGYGLPISRLYARYFGGDLQIISMEGYGTDAYLHLSRLG-DSQEPLP 475
+AGYGYGLP+SRLYARYF GD+ ++SMEGYGTDA + L + ++ E LP
Sbjct: 319 LAGYGYGLPLSRLYARYFHGDMYLVSMEGYGTDAMIFLKAIPVEASEVLP 368
>sp|Q1KMR4|PDK4_RHIFE [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 4,
mitochondrial OS=Rhinolophus ferrumequinum GN=PDK4 PE=2 SV=1
Length = 412
Score = 164 bits (415), Expect = 9e-040
Identities = 93/229 (40%), Positives = 138/229 (60%), Gaps = 17/229 (7%)
Frame = -2
Query: 1131 IHQFLDRFYMSRIGIRMLIGQHVELHNPNPP--PHCVGYIHTKMSPLEVARNASEDARSI 958
+ FLDRFYM+RI RML+ QH+ + + + P +G I + V ++A E +R +
Sbjct: 155 LQYFLDRFYMNRISTRMLMNQHILIFSDSQTGNPSHIGSIDPNCNVAAVVQDAFECSRML 214
Query: 957 CFHEYGSAPNVNIY-------GDPDFTFPYVPTHLHLMVFELVKNSLRAVQERFMDSDKV 799
C Y ++P + + G+P YVP+HLH M+FEL KN++RA E +++
Sbjct: 215 CDQYYLTSPELKLTQVNGKFPGEP-IHIVYVPSHLHHMLFELFKNAMRATVEH-QENEPS 272
Query: 798 APPIRIIVADGIEDVTIKVSDEGGGIPRSGLPKIFTYLYSTAANHVDEQTDLGTTDSVTM 619
P+ + V G ED+TIK+SD GGG+P ++F+Y+YSTA V + + + +
Sbjct: 273 LTPVEVTVVLGKEDLTIKISDRGGGVPLRITDRLFSYMYSTAPTPV-----MDNSRNAPL 327
Query: 618 AGYGYGLPISRLYARYFGGDLQIISMEGYGTDAYLHLSRL-GDSQEPLP 475
AG+GYGLPISRLYA+YF GDL + S+ GYGTDA ++L L +S E LP
Sbjct: 328 AGFGYGLPISRLYAKYFQGDLHLYSLSGYGTDAIIYLKALSSESVEKLP 376
>sp|O70571|PDK4_MOUSE [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 4,
mitochondrial OS=Mus musculus GN=Pdk4 PE=2 SV=1
Length = 412
Score = 163 bits (412), Expect = 2e-039
Identities = 93/228 (40%), Positives = 134/228 (58%), Gaps = 15/228 (6%)
Frame = -2
Query: 1131 IHQFLDRFYMSRIGIRMLIGQHVELHNPNPP--PHCVGYIHTKMSPLEVARNASEDARSI 958
+ FLDRFYM+RI RML+ QH+ + + + P +G I + V ++A E A+ +
Sbjct: 155 LQYFLDRFYMNRISTRMLMNQHILIFSDSKTGNPSHIGSIDPNCDVVAVVQDAFECAKML 214
Query: 957 CFHEYGSAPNVNI------YGDPDFTFPYVPTHLHLMVFELVKNSLRAVQERFMDSDKVA 796
C Y ++P +N+ + YVP+HLH M+FEL KN++RA E ++
Sbjct: 215 CDQYYLTSPELNLTQVNGKFPGQPIHIVYVPSHLHHMLFELFKNAMRATVEH-QENRPSL 273
Query: 795 PPIRIIVADGIEDVTIKVSDEGGGIPRSGLPKIFTYLYSTAANHVDEQTDLGTTDSVTMA 616
P+ V G ED+TIK+SD GGG+P ++F+Y YSTA V + + + +A
Sbjct: 274 TPVEATVVLGKEDLTIKISDRGGGVPLRITDRLFSYTYSTAPTPV-----MDNSRNAPLA 328
Query: 615 GYGYGLPISRLYARYFGGDLQIISMEGYGTDAYLHLSRL-GDSQEPLP 475
G+GYGLPISRLYA+YF GDL + SM GYGTDA ++L L +S E LP
Sbjct: 329 GFGYGLPISRLYAKYFQGDLNLYSMSGYGTDAIIYLKALSSESVEKLP 376
>sp|O54937|PDK4_RAT [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 4,
mitochondrial OS=Rattus norvegicus GN=Pdk4 PE=2 SV=1
Length = 412
Score = 161 bits (405), Expect = 1e-038
Identities = 92/228 (40%), Positives = 132/228 (57%), Gaps = 15/228 (6%)
Frame = -2
Query: 1131 IHQFLDRFYMSRIGIRMLIGQHVELHNPNPP--PHCVGYIHTKMSPLEVARNASEDARSI 958
+ FLDRFYM+RI RML+ QH+ + + + P +G I + V +A E A+ +
Sbjct: 155 LQYFLDRFYMNRISTRMLMNQHILIFSDSKTGNPSHIGSIDPNCDVVAVVEDAFECAKML 214
Query: 957 CFHEYGSAPNVNI------YGDPDFTFPYVPTHLHLMVFELVKNSLRAVQERFMDSDKVA 796
C Y ++P + + + YVP+HLH M+FEL KN++RA E ++
Sbjct: 215 CDQYYLTSPELKLTQVNGKFPGQPIHIVYVPSHLHHMLFELFKNAMRATVEH-QENRPFL 273
Query: 795 PPIRIIVADGIEDVTIKVSDEGGGIPRSGLPKIFTYLYSTAANHVDEQTDLGTTDSVTMA 616
P+ V G ED+TIK+SD GGG+P ++F+Y YSTA V + + + +A
Sbjct: 274 TPVEATVVLGKEDLTIKISDRGGGVPLRITDRLFSYTYSTAPTPV-----MDNSRNAPLA 328
Query: 615 GYGYGLPISRLYARYFGGDLQIISMEGYGTDAYLHLSRL-GDSQEPLP 475
G+GYGLPISRLYA+YF GDL + SM GYGTDA ++L L +S E LP
Sbjct: 329 GFGYGLPISRLYAKYFQGDLNLYSMSGYGTDAIIYLKALSSESIEKLP 376
>sp|Q02332|PDK_CAEEL Probable [pyruvate dehydrogenase [lipoamide]] kinase,
mitochondrial OS=Caenorhabditis elegans GN=ZK370.5 PE=2 SV=1
Length = 401
Score = 156 bits (392), Expect = 4e-037
Identities = 96/230 (41%), Positives = 137/230 (59%), Gaps = 20/230 (8%)
Frame = -2
Query: 1131 IHQFLDRFYMSRIGIRMLIGQHVELHN---PNPPPHCVGYIHTKMSPLEVARNASEDARS 961
I FLDRFY++RI IRML QH+ + P P H VG I V +A E+AR
Sbjct: 148 IQYFLDRFYINRISIRMLQNQHLVVFGNVLPESPRH-VGCIDPACDVESVVYDAFENARF 206
Query: 960 ICFHEYGSAPNVNI-------YGDPDFTFPYVPTHLHLMVFELVKNSLRAVQERFMDSDK 802
+C Y ++P++ + G P + VP+HL+ M+FEL KN++RA E + D
Sbjct: 207 LCDRYYLTSPSMKLEMHNAVEKGKP-ISIVAVPSHLYHMMFELFKNAMRATVE-YHGVDD 264
Query: 801 VAPPIRIIVADGIEDVTIKVSDEGGGIPRSGLPKIFTYLYSTAANHVDEQTDLGTTDSVT 622
P I++ V G ED++IK+ D GGG+ R+ L +++ Y+YSTA + T
Sbjct: 265 DLPDIKVYVVKGQEDLSIKICDRGGGVSRTILERLYNYMYSTAPPPPRDGT------QAP 318
Query: 621 MAGYGYGLPISRLYARYFGGDLQIISMEGYGTDAYLHLSRLG-DSQEPLP 475
+AGYGYGLP+SRLYARYF GDL ++SMEG+GTDA ++L + ++ E LP
Sbjct: 319 LAGYGYGLPLSRLYARYFLGDLFLVSMEGHGTDACIYLKAVPVEASEVLP 368
>sp|Q8BFP9|PDK1_MOUSE [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 1,
mitochondrial OS=Mus musculus GN=Pdk1 PE=2 SV=1
Length = 434
Score = 149 bits (376), Expect = 3e-035
Identities = 84/192 (43%), Positives = 123/192 (64%), Gaps = 13/192 (6%)
Frame = -2
Query: 1029 VGYIHTKMSPLEVARNASEDARSICFHEYGSAPNVNI----YGDPDFTFP--YVPTHLHL 868
+G I+ +EV ++ E+AR +C Y ++P + + P T YVP+HL+
Sbjct: 214 IGSINPNCDVVEVIKDGYENARRLCDLYYVNSPELELEELNAKSPGQTIQVVYVPSHLYH 273
Query: 867 MVFELVKNSLRAVQERFMDSDKVAPPIRIIVADGIEDVTIKVSDEGGGIPRSGLPKIFTY 688
MVFEL KN++RA E D V PPI++ V G ED+T+K+SD GGG+P S + ++F Y
Sbjct: 274 MVFELFKNAMRATMEHHADKG-VYPPIQVHVTLGEEDLTVKMSDRGGGVPLSKIDRLFNY 332
Query: 687 LYSTAANHVDEQTDLGTTDSVTMAGYGYGLPISRLYARYFGGDLQIISMEGYGTDAYLHL 508
+YSTA + + T+ +V +AG+GYGLPISRLYA+YF GDL++ S+EGYGTDA +++
Sbjct: 333 MYSTA-----PRPRVETSRAVPLAGFGYGLPISRLYAQYFQGDLKLYSLEGYGTDAVIYI 387
Query: 507 SRLG-DSQEPLP 475
L +S E LP
Sbjct: 388 KALSTESVERLP 399
>sp|Q15118|PDK1_HUMAN [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 1,
mitochondrial OS=Homo sapiens GN=PDK1 PE=1 SV=1
Length = 436
Score = 148 bits (373), Expect = 7e-035
Identities = 85/193 (44%), Positives = 122/193 (63%), Gaps = 15/193 (7%)
Frame = -2
Query: 1029 VGYIHTKMSPLEVARNASEDARSICFHEYGSAP-------NVNIYGDPDFTFPYVPTHLH 871
+G I+ + LEV ++ E+AR +C Y ++P N G P YVP+HL+
Sbjct: 216 IGSINPNCNVLEVIKDGYENARRLCDLYYINSPELELEELNAKSPGQP-IQVVYVPSHLY 274
Query: 870 LMVFELVKNSLRAVQERFMDSDKVAPPIRIIVADGIEDVTIKVSDEGGGIPRSGLPKIFT 691
MVFEL KN++RA E + V PPI++ V G ED+T+K+SD GGG+P + ++F
Sbjct: 275 HMVFELFKNAMRATMEHHANRG-VYPPIQVHVTLGNEDLTVKMSDRGGGVPLRKIDRLFN 333
Query: 690 YLYSTAANHVDEQTDLGTTDSVTMAGYGYGLPISRLYARYFGGDLQIISMEGYGTDAYLH 511
Y+YSTA + + T+ +V +AG+GYGLPISRLYA+YF GDL++ S+EGYGTDA ++
Sbjct: 334 YMYSTA-----PRPRVETSRAVPLAGFGYGLPISRLYAQYFQGDLKLYSLEGYGTDAVIY 388
Query: 510 LSRLG-DSQEPLP 475
+ L DS E LP
Sbjct: 389 IKALSTDSIERLP 401
>sp|Q63065|PDK1_RAT [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 1,
mitochondrial OS=Rattus norvegicus GN=Pdk1 PE=1 SV=1
Length = 434
Score = 148 bits (372), Expect = 9e-035
Identities = 84/193 (43%), Positives = 121/193 (62%), Gaps = 15/193 (7%)
Frame = -2
Query: 1029 VGYIHTKMSPLEVARNASEDARSICFHEYGSAP-------NVNIYGDPDFTFPYVPTHLH 871
+G I+ +EV ++ E+AR +C Y ++P N G P YVP+HL+
Sbjct: 214 IGSINPNCDVVEVIKDGYENARRLCDLYYVNSPELELEELNAKSPGQP-IQVVYVPSHLY 272
Query: 870 LMVFELVKNSLRAVQERFMDSDKVAPPIRIIVADGIEDVTIKVSDEGGGIPRSGLPKIFT 691
MVFEL KN++RA E D V PPI++ V G ED+T+K+SD GGG+P + ++F
Sbjct: 273 HMVFELFKNAMRATMEHHADKG-VYPPIQVHVTLGEEDLTVKMSDRGGGVPLRKIDRLFN 331
Query: 690 YLYSTAANHVDEQTDLGTTDSVTMAGYGYGLPISRLYARYFGGDLQIISMEGYGTDAYLH 511
Y+YSTA + + T+ +V +AG+GYGLPISRLYA+YF GDL++ S+EGYGTDA ++
Sbjct: 332 YMYSTA-----PRPRVETSRAVPLAGFGYGLPISRLYAQYFQGDLKLYSLEGYGTDAVIY 386
Query: 510 LSRLG-DSQEPLP 475
+ L +S E LP
Sbjct: 387 IKALSTESIERLP 399
>sp|Q2KJG8|BCKD_BOVIN [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]]
kinase, mitochondrial OS=Bos taurus GN=BCKDK PE=2 SV=1
Length = 412
Score = 114 bits (284), Expect = 1e-024
Identities = 60/158 (37%), Positives = 91/158 (57%), Gaps = 2/158 (1%)
Frame = -2
Query: 1146 EDLDEIHQFLDRFYMSRIGIRMLIGQHVELHNPNPPPHCVGYIHTKMSPLEVARNASEDA 967
ED + FLD+ SR+GIRML H+ LH P VG I T++SP ++ + A
Sbjct: 181 EDEKLVRYFLDKTLTSRLGIRMLATHHLALHEDK--PDFVGIICTRLSPKKIIEKWVDFA 238
Query: 966 RSICFHEYGSAPNVNIYGDPDFTFPYVPTHLHLMVFELVKNSLRAVQERFMDSDKVAPPI 787
R +C H+YG+AP V I G FP++P L ++ EL+KN++RA E +D+ P +
Sbjct: 239 RRLCEHKYGNAPRVRINGHVAARFPFIPMPLDYILPELLKNAMRATMESHLDTPYNVPDV 298
Query: 786 RIIVADGIEDVTIKVSDEGGGIPRSGLPKIFTYLYSTA 673
I +A+ D+ I++SD GGGI L ++ Y ++TA
Sbjct: 299 VITIANNDIDLVIRISDRGGGIAHKDLDRVMDYHFTTA 336
>sp|O14874|BCKD_HUMAN [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]]
kinase, mitochondrial OS=Homo sapiens GN=BCKDK PE=1 SV=2
Length = 412
Score = 114 bits (284), Expect = 1e-024
Identities = 60/158 (37%), Positives = 91/158 (57%), Gaps = 2/158 (1%)
Frame = -2
Query: 1146 EDLDEIHQFLDRFYMSRIGIRMLIGQHVELHNPNPPPHCVGYIHTKMSPLEVARNASEDA 967
ED + FLD+ SR+GIRML H+ LH P VG I T++SP ++ + A
Sbjct: 181 EDEKLVRYFLDKTLTSRLGIRMLATHHLALHEDK--PDFVGIICTRLSPKKIIEKWVDFA 238
Query: 966 RSICFHEYGSAPNVNIYGDPDFTFPYVPTHLHLMVFELVKNSLRAVQERFMDSDKVAPPI 787
R +C H+YG+AP V I G FP++P L ++ EL+KN++RA E +D+ P +
Sbjct: 239 RRLCEHKYGNAPRVRINGHVAARFPFIPMPLDYILPELLKNAMRATMESHLDTPYNVPDV 298
Query: 786 RIIVADGIEDVTIKVSDEGGGIPRSGLPKIFTYLYSTA 673
I +A+ D+ I++SD GGGI L ++ Y ++TA
Sbjct: 299 VITIANNDVDLIIRISDRGGGIAHKDLDRVMDYHFTTA 336
>sp|Q00972|BCKD_RAT [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase,
mitochondrial OS=Rattus norvegicus GN=Bckdk PE=1 SV=2
Length = 412
Score = 114 bits (284), Expect = 1e-024
Identities = 60/158 (37%), Positives = 91/158 (57%), Gaps = 2/158 (1%)
Frame = -2
Query: 1146 EDLDEIHQFLDRFYMSRIGIRMLIGQHVELHNPNPPPHCVGYIHTKMSPLEVARNASEDA 967
ED + FLD+ SR+GIRML H+ LH P VG I T++SP ++ + A
Sbjct: 181 EDEKLVRYFLDKTLTSRLGIRMLATHHLALHEDK--PDFVGIICTRLSPKKIIEKWVDFA 238
Query: 966 RSICFHEYGSAPNVNIYGDPDFTFPYVPTHLHLMVFELVKNSLRAVQERFMDSDKVAPPI 787
R +C H+YG+AP V I G FP++P L ++ EL+KN++RA E +D+ P +
Sbjct: 239 RRLCEHKYGNAPRVRINGHVAARFPFIPMPLDYILPELLKNAMRATMESHLDTPYNVPDV 298
Query: 786 RIIVADGIEDVTIKVSDEGGGIPRSGLPKIFTYLYSTA 673
I +A+ D+ I++SD GGGI L ++ Y ++TA
Sbjct: 299 VITIANNDVDLIIRISDRGGGIAHKDLDRVMDYHFTTA 336
>sp|O55028|BCKD_MOUSE [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]]
kinase, mitochondrial OS=Mus musculus GN=Bckdk PE=1 SV=1
Length = 412
Score = 112 bits (280), Expect = 4e-024
Identities = 59/158 (37%), Positives = 91/158 (57%), Gaps = 2/158 (1%)
Frame = -2
Query: 1146 EDLDEIHQFLDRFYMSRIGIRMLIGQHVELHNPNPPPHCVGYIHTKMSPLEVARNASEDA 967
+D + FLD+ SR+GIRML H+ LH P VG I T++SP ++ + A
Sbjct: 181 QDEKLVRYFLDKTLTSRLGIRMLATHHLALHEDK--PDFVGIICTRLSPKKIIEKWVDFA 238
Query: 966 RSICFHEYGSAPNVNIYGDPDFTFPYVPTHLHLMVFELVKNSLRAVQERFMDSDKVAPPI 787
R +C H+YG+AP V I G FP++P L ++ EL+KN++RA E +D+ P +
Sbjct: 239 RRLCEHKYGNAPRVRINGHVAARFPFIPMPLDYILPELLKNAMRATMESHLDTPYNVPDV 298
Query: 786 RIIVADGIEDVTIKVSDEGGGIPRSGLPKIFTYLYSTA 673
I +A+ D+ I++SD GGGI L ++ Y ++TA
Sbjct: 299 VITIANNDIDLIIRISDRGGGIAHKDLDRVMDYHFTTA 336
Database: UniProt/Swiss-Prot
Posted date: Thu Apr 23 14:22:33 2009
Number of letters in database: 163,773,382
Number of sequences in database: 462,764
Lambda K H
0.267 0.041 0.140
Gapped
Lambda K H
0.267 0.041 0.140
Matrix: blosum62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 8,390,147,223
Number of Sequences: 462764
Number of Extensions: 8390147223
Number of Successful Extensions: 74969301
Number of sequences better than 0.0: 0
|