BLASTX 7.6.2
Query= RU05878 /QuerySize=1821
(1820 letters)
Database: UniProt/Swiss-Prot;
462,764 sequences; 163,773,382 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q54Z26|GLYC1_DICDI Serine hydroxymethyltransferase 1 OS=Dicty... 584 7e-166
sp|Q54EW1|GLYC2_DICDI Serine hydroxymethyltransferase 2 OS=Dicty... 580 2e-164
sp|P34899|GLYM_PEA Serine hydroxymethyltransferase, mitochondria... 540 1e-152
sp|Q9SZJ5|GLYM_ARATH Serine hydroxymethyltransferase, mitochondr... 537 2e-151
sp|P49357|GLYM_FLAPR Serine hydroxymethyltransferase 1, mitochon... 531 7e-150
sp|Q3SZ20|GLYM_BOVIN Serine hydroxymethyltransferase, mitochondr... 530 2e-149
sp|P49358|GLYN_FLAPR Serine hydroxymethyltransferase 2, mitochon... 527 9e-149
sp|P50433|GLYM_SOLTU Serine hydroxymethyltransferase, mitochondr... 526 2e-148
sp|P14519|GLYM_RABIT Serine hydroxymethyltransferase, mitochondr... 524 8e-148
sp|P34897|GLYM_HUMAN Serine hydroxymethyltransferase, mitochondr... 523 1e-147
sp|P50432|GLYC_CAEEL Serine hydroxymethyltransferase OS=Caenorha... 522 5e-147
sp|P07511|GLYC_RABIT Serine hydroxymethyltransferase, cytosolic ... 522 5e-147
sp|Q5RFK5|GLYC_PONAB Serine hydroxymethyltransferase, cytosolic ... 520 1e-146
sp|Q5E9P9|GLYC_BOVIN Serine hydroxymethyltransferase, cytosolic ... 520 2e-146
sp|P34896|GLYC_HUMAN Serine hydroxymethyltransferase, cytosolic ... 519 3e-146
sp|Q60V73|GLYC_CAEBR Serine hydroxymethyltransferase OS=Caenorha... 519 3e-146
sp|P35623|GLYC_SHEEP Serine hydroxymethyltransferase, cytosolic ... 519 3e-146
sp|P50431|GLYC_MOUSE Serine hydroxymethyltransferase, cytosolic ... 518 4e-146
sp|Q10104|GLYC_SCHPO Probable serine hydroxymethyltransferase, c... 490 2e-137
sp|P34898|GLYC_NEUCR Serine hydroxymethyltransferase, cytosolic ... 486 2e-136
sp|Q6CLQ5|GLYM_KLULA Serine hydroxymethyltransferase, mitochondr... 464 1e-129
sp|Q6FQ44|GLYM_CANGA Serine hydroxymethyltransferase, mitochondr... 463 2e-129
sp|Q75BQ6|GLYC_ASHGO Serine hydroxymethyltransferase, cytosolic ... 461 6e-129
sp|Q758F0|GLYM_ASHGO Serine hydroxymethyltransferase, mitochondr... 458 5e-128
sp|O13425|GLYM_CANAL Serine hydroxymethyltransferase, mitochondr... 454 1e-126
sp|P37292|GLYM_YEAST Serine hydroxymethyltransferase, mitochondr... 450 2e-125
>sp|Q54Z26|GLYC1_DICDI Serine hydroxymethyltransferase 1 OS=Dictyostelium
discoideum GN=shmt1 PE=1 SV=1
Length = 457
Score = 584 bits (1505), Expect = 7e-166
Identities = 290/454 (63%), Positives = 358/454 (78%), Gaps = 3/454 (0%)
Frame = +1
Query: 79 GNTNLEAVDPEIHDLIEKEKRRQCRGIELIASENFTSFAVIEALGSALTNKYSEGMPGNR 258
GNT L+ VD EI +L+ +EK RQ +G+ELIASENFTS AV+EALGS TNKY+EG PG+R
Sbjct: 6 GNTPLKEVDNEIFELMNREKDRQFKGLELIASENFTSRAVMEALGSHFTNKYAEGYPGSR 65
Query: 259 YYGGNEYIDQIENLCRSRALQAFHLDASQWGVNVQPYSGSPANFAAYTAVLQPHDRIMGL 438
YYGG E +D++E LC+ RAL+AF LD S+WGVNVQPYSGSPANFA YTA+L+PHDRIMGL
Sbjct: 66 YYGGTEVVDELETLCQKRALKAFRLDESKWGVNVQPYSGSPANFAVYTALLRPHDRIMGL 125
Query: 439 DLPSGGHLTHGYYTSGGKKISATSIYFESLPYKVNSSTGYIDYDKLEEKALDFRPRLIIC 618
DLPSGGHLTHGY T KKISA+SI+FES+PY++ + G IDY +LEE AL F+P+LII
Sbjct: 126 DLPSGGHLTHGYQTD-KKKISASSIFFESMPYQIGAD-GLIDYQRLEENALLFKPKLIIS 183
Query: 619 GGSAYPRDWDYARFRAVADKCGALLLCDMAHISGLVCAQEAANPFEFCDIVTTTTHKSLR 798
G SAYPR+WDY R RA+ADK GA L+CDMAH SGLV AQ +PF++CD+VT+TTHK+LR
Sbjct: 184 GASAYPREWDYKRMRAIADKVGAYLMCDMAHYSGLVAAQLLDSPFDYCDVVTSTTHKTLR 243
Query: 799 GPRAGMIFYRXXXXXXXXXXXEGAEYDFEDKINFAVFPSLQGGPHNHQIGALAVALKQAM 978
GPR+G+IF+R E EYD E KINFAVFPSLQGGPH + I +AVALK+A
Sbjct: 244 GPRSGIIFFR-RGKRVDGNGKEIEEYDIESKINFAVFPSLQGGPHENVIAGVAVALKEAD 302
Query: 979 TPGFKAYAQQVKANAVALGKYLMSKDYKLVTGGTENHLVLWDLRPLGLTGNKVEKLCDLA 1158
+ FK YA QVK NA A+G LM+K YKLVT GT+NHL+LWDLRP LTGNK EK D+A
Sbjct: 303 SQEFKEYALQVKKNAAAIGNALMNKGYKLVTNGTDNHLILWDLRPKELTGNKFEKAADIA 362
Query: 1159 NITVNKNAVFGDSSALAPGGVRIGAPAMTSRGLVEKDFEKIGEFLHRAVTLTLKIQKEFG 1338
NITVNKNAV GD++A++PGG+RIG+ A+TSRGL E DFEKI +FL R V+++L+IQ G
Sbjct: 363 NITVNKNAVHGDTNAISPGGIRIGSSALTSRGLKEADFEKIADFLDRIVSISLEIQGRVG 422
Query: 1339 KLLKDFNKGLVNNKEIEELKADVEKFSASFDMPG 1440
K L DF + +KE+ +L+ +VE+FS+ F +PG
Sbjct: 423 KKLVDFVVEINKSKELLDLRKEVEEFSSKFTLPG 456
>sp|Q54EW1|GLYC2_DICDI Serine hydroxymethyltransferase 2 OS=Dictyostelium
discoideum GN=shmt2 PE=3 SV=1
Length = 481
Score = 580 bits (1493), Expect = 2e-164
Identities = 275/453 (60%), Positives = 358/453 (79%), Gaps = 4/453 (0%)
Frame = +1
Query: 82 NTNLEAVDPEIHDLIEKEKRRQCRGIELIASENFTSFAVIEALGSALTNKYSEGMPGNRY 261
N ++ DPEI+DL+ KEK+RQ G+ELIASENFTS AV+E++GS TNKY+EG+PG RY
Sbjct: 31 NRSVSESDPEIYDLMMKEKQRQFTGLELIASENFTSRAVMESIGSCFTNKYAEGLPGARY 90
Query: 262 YGGNEYIDQIENLCRSRALQAFHLDASQWGVNVQPYSGSPANFAAYTAVLQPHDRIMGLD 441
YGGNE +DQ+ENLC RAL+ F+L+ +WGVNVQPYSGS ANFAA+T +L+PHDRIMGLD
Sbjct: 91 YGGNEVVDQLENLCIKRALETFNLNPEEWGVNVQPYSGSTANFAAFTGLLKPHDRIMGLD 150
Query: 442 LPSGGHLTHGYYTSGGKKISATSIYFESLPYKVNSSTGYIDYDKLEEKALDFRPRLIICG 621
LPSGGHLTHGY T KKISATSI+FES+PY+VN TGY+DY+K+E A FRP+L+I G
Sbjct: 151 LPSGGHLTHGYQTD-KKKISATSIFFESMPYQVN-ETGYVDYNKMEANAALFRPKLLIAG 208
Query: 622 GSAYPRDWDYARFRAVADKCGALLLCDMAHISGLVCAQEAANPFEFCDIVTTTTHKSLRG 801
SAYPR+WDY R R +ADK GA LLCDMAHISG+V ++A +PF FCD+VTTTTHK+LRG
Sbjct: 209 ASAYPREWDYERMRKIADKHGAYLLCDMAHISGMVAGKQAISPFLFCDVVTTTTHKTLRG 268
Query: 802 PRAGMIFYRXXXXXXXXXXXEGAEYDFEDKINFAVFPSLQGGPHNHQIGALAVALKQAMT 981
PRAG+IF+R + D E++INFAVFPS QGGPH + I +AVALK+A +
Sbjct: 269 PRAGLIFFRKTKRRDAKGNI--IDDDLENRINFAVFPSCQGGPHENTIAGIAVALKEASS 326
Query: 982 PGFKAYAQQVKANAVALGKYLMSKDYKLVTGGTENHLVLWDLRPLGLTGNKVEKLCDLAN 1161
P F+ Y +QV+ N+ +G+ L + Y LVT GT+NHLVLWDLRP G+TG+K+EK CD A+
Sbjct: 327 PDFQEYTKQVRRNSQTMGEELKKRGYSLVTEGTDNHLVLWDLRPQGITGSKIEKACDEAH 386
Query: 1162 ITVNKNAVFGDSSALAPGGVRIGAPAMTSRGLVEKDFEKIGEFLHRAVTLTLKIQKEFGK 1341
ITVNKNAV+GD++A+APGGVR+GAPA+TSRGL E+DF K+ +FL R V ++L IQ + GK
Sbjct: 387 ITVNKNAVYGDTNAIAPGGVRLGAPALTSRGLKEQDFVKVVDFLDRVVKISLDIQSKVGK 446
Query: 1342 LLKDFNKGLVNNKEIEELKADVEKFSASFDMPG 1440
+ DF + + +N+++++++ +V++FS F MPG
Sbjct: 447 KMPDFQRAIADNQDLKQIRQEVKEFSTKFGMPG 479
>sp|P34899|GLYM_PEA Serine hydroxymethyltransferase, mitochondrial OS=Pisum
sativum PE=1 SV=1
Length = 518
Score = 540 bits (1390), Expect = 1e-152
Identities = 275/466 (59%), Positives = 342/466 (73%), Gaps = 7/466 (1%)
Frame = +1
Query: 82 NTNLEAVDPEIHDLIEKEKRRQCRGIELIASENFTSFAVIEALGSALTNKYSEGMPGNRY 261
N+ LE +DPEI D+IE EK RQ +G+ELI SENFTS +V++A+GS +TNKYSEG PG RY
Sbjct: 53 NSPLEVIDPEIADIIELEKARQWKGLELIPSENFTSLSVMQAVGSVMTNKYSEGYPGARY 112
Query: 262 YGGNEYIDQIENLCRSRALQAFHLDASQWGVNVQPYSGSPANFAAYTAVLQPHDRIMGLD 441
YGGNEYID E LC+ RAL+AF LD ++WGVNVQP SGSP+NF YTA+L+PHDRIM LD
Sbjct: 113 YGGNEYIDMAETLCQKRALEAFRLDPAKWGVNVQPLSGSPSNFQVYTALLKPHDRIMALD 172
Query: 442 LPSGGHLTHGYYTSGGKKISATSIYFESLPYKVNSSTGYIDYDKLEEKALDFRPRLIICG 621
LP GGHL+HGY T KKISA SI+FE++PY+++ STGYIDYD+LE+ A FRP+LI+ G
Sbjct: 173 LPHGGHLSHGYQTD-TKKISAVSIFFETMPYRLDESTGYIDYDQLEKSATLFRPKLIVAG 231
Query: 622 GSAYPRDWDYARFRAVADKCGALLLCDMAHISGLVCAQEAANPFEFCDIVTTTTHKSLRG 801
SAY R +DYAR R V DK A+LL DMAHISGLV A +PF++ D+VTTTTHKSLRG
Sbjct: 232 ASAYARLYDYARIRKVCDKQKAVLLADMAHISGLVAAGVIPSPFDYADVVTTTTHKSLRG 291
Query: 802 PRAGMIFYRXXXXXXXXXXXEGAEYDFEDKINFAVFPSLQGGPHNHQIGALAVALKQAMT 981
PR MIF+R E YD+EDKIN AVFP LQGGPHNH I LAVALKQA T
Sbjct: 292 PRGAMIFFRKGLKEVNKQGKE-VFYDYEDKINQAVFPGLQGGPHNHTITGLAVALKQATT 350
Query: 982 PGFKAYAQQVKANAVALGKYLMSKDYKLVTGGTENHLVLWDLRPLGLTGNKVEKLCDLAN 1161
P ++AY +QV +N+ K L K Y LV+GGTENHLVL +L+ G+ G++VEK+ +L +
Sbjct: 351 PEYRAYQEQVLSNSSKFAKALSEKGYDLVSGGTENHLVLVNLKNKGIDGSRVEKVLELVH 410
Query: 1162 ITVNKNAVFGDSSALAPGGVRIGAPAMTSRGLVEKDFEKIGEFLHRAVTLTLKIQKEF-G 1338
I NKN V GD SA+ PGG+R+G PA+TSRG VE+DF K+ E+ AV+L LK++ E G
Sbjct: 411 IAANKNTVPGDVSAMVPGGIRMGTPALTSRGFVEEDFVKVAEYFDAAVSLALKVKAESKG 470
Query: 1339 KLLKDFNKGLVNN----KEIEELKADVEKFSASFDMPGFQMSQMKY 1464
LKDF + L + EI +LK DVE+F+ F GF+ + MKY
Sbjct: 471 TKLKDFVEALQTSSYVQSEISKLKHDVEEFAKQFPTIGFEKATMKY 516
>sp|Q9SZJ5|GLYM_ARATH Serine hydroxymethyltransferase, mitochondrial
OS=Arabidopsis thaliana GN=SHM1 PE=1 SV=1
Length = 517
Score = 537 bits (1381), Expect = 2e-151
Identities = 270/468 (57%), Positives = 343/468 (73%), Gaps = 7/468 (1%)
Frame = +1
Query: 82 NTNLEAVDPEIHDLIEKEKRRQCRGIELIASENFTSFAVIEALGSALTNKYSEGMPGNRY 261
N LE VDPEI D+IE EK RQ +G+ELI SENFTS +V++A+GS +TNKYSEG PG RY
Sbjct: 52 NAPLEEVDPEIADIIEHEKARQWKGLELIPSENFTSVSVMQAVGSVMTNKYSEGYPGARY 111
Query: 262 YGGNEYIDQIENLCRSRALQAFHLDASQWGVNVQPYSGSPANFAAYTAVLQPHDRIMGLD 441
YGGNEYID E LC+ RAL+AF LD +WGVNVQP SGSPANF YTA+L+PH+RIM LD
Sbjct: 112 YGGNEYIDMAETLCQKRALEAFRLDPEKWGVNVQPLSGSPANFHVYTALLKPHERIMALD 171
Query: 442 LPSGGHLTHGYYTSGGKKISATSIYFESLPYKVNSSTGYIDYDKLEEKALDFRPRLIICG 621
LP GGHL+HGY T KKISA SI+FE++PY+++ STGYIDYD++E+ A FRP+LI+ G
Sbjct: 172 LPHGGHLSHGYQTD-TKKISAVSIFFETMPYRLDESTGYIDYDQMEKSATLFRPKLIVAG 230
Query: 622 GSAYPRDWDYARFRAVADKCGALLLCDMAHISGLVCAQEAANPFEFCDIVTTTTHKSLRG 801
SAY R +DYAR R V +K A++L DMAHISGLV A +PF++ D+VTTTTHKSLRG
Sbjct: 231 ASAYARLYDYARIRKVCNKQKAVMLADMAHISGLVAANVIPSPFDYADVVTTTTHKSLRG 290
Query: 802 PRAGMIFYRXXXXXXXXXXXEGAEYDFEDKINFAVFPSLQGGPHNHQIGALAVALKQAMT 981
PR MIF+R E YDFEDKIN AVFP LQGGPHNH I LAVALKQA T
Sbjct: 291 PRGAMIFFRKGVKEINKQGKE-VLYDFEDKINQAVFPGLQGGPHNHTITGLAVALKQATT 349
Query: 982 PGFKAYAQQVKANAVALGKYLMSKDYKLVTGGTENHLVLWDLRPLGLTGNKVEKLCDLAN 1161
+KAY +QV +N+ + LM + Y+LV+GGT+NHLVL +L+P G+ G++VEK+ + +
Sbjct: 350 SEYKAYQEQVLSNSAKFAQTLMERGYELVSGGTDNHLVLVNLKPKGIDGSRVEKVLEAVH 409
Query: 1162 ITVNKNAVFGDSSALAPGGVRIGAPAMTSRGLVEKDFEKIGEFLHRAVTLTLKIQKEF-G 1338
I NKN V GD SA+ PGG+R+G PA+TSRG VE+DF K+ E+ +AVT+ LK++ E G
Sbjct: 410 IASNKNTVPGDVSAMVPGGIRMGTPALTSRGFVEEDFAKVAEYFDKAVTIALKVKSEAQG 469
Query: 1339 KLLKDFNKGLVNN----KEIEELKADVEKFSASFDMPGFQMSQMKYKD 1470
LKDF + ++ EI +L+ +VE+F+ F GF+ MKYK+
Sbjct: 470 TKLKDFVSAMESSSTIQSEIAKLRHEVEEFAKQFPTIGFEKETMKYKN 517
>sp|P49357|GLYM_FLAPR Serine hydroxymethyltransferase 1, mitochondrial
OS=Flaveria pringlei PE=2 SV=1
Length = 517
Score = 531 bits (1367), Expect = 7e-150
Identities = 272/467 (58%), Positives = 338/467 (72%), Gaps = 6/467 (1%)
Frame = +1
Query: 82 NTNLEAVDPEIHDLIEKEKRRQCRGIELIASENFTSFAVIEALGSALTNKYSEGMPGNRY 261
N LE VDPEI D+IE EK RQ +G+ELI SENFTS +V++A+GS +TNKYSEG PG RY
Sbjct: 53 NAPLEVVDPEIADIIELEKARQWKGLELIPSENFTSLSVMQAVGSVMTNKYSEGYPGARY 112
Query: 262 YGGNEYIDQIENLCRSRALQAFHLDASQWGVNVQPYSGSPANFAAYTAVLQPHDRIMGLD 441
YGGNEYID E LC+ RAL+AF LD ++WGVNVQP SGSPANF YTA+L+ HDRIM LD
Sbjct: 113 YGGNEYIDMAETLCQKRALEAFRLDPAKWGVNVQPLSGSPANFHVYTALLKAHDRIMALD 172
Query: 442 LPSGGHLTHGYYTSGGKKISATSIYFESLPYKVNSSTGYIDYDKLEEKALDFRPRLIICG 621
LP GGHL+HGY T KKISA SI+FE++PY++N STGYIDYD+LE+ A FRP+LI+ G
Sbjct: 173 LPHGGHLSHGYQTD-TKKISAVSIFFETMPYRLNESTGYIDYDQLEKSATLFRPKLIVAG 231
Query: 622 GSAYPRDWDYARFRAVADKCGALLLCDMAHISGLVCAQEAANPFEFCDIVTTTTHKSLRG 801
SAY R +DYAR R V DK A++L DMAHISGLV A +PF++ D+VTTTTHKSLRG
Sbjct: 232 ASAYARLYDYARIRKVCDKQKAIMLADMAHISGLVAAGVIPSPFDYADVVTTTTHKSLRG 291
Query: 802 PRAGMIFYRXXXXXXXXXXXEGAEYDFEDKINFAVFPSLQGGPHNHQIGALAVALKQAMT 981
PR MIF+R E YD+EDKIN AVFP LQGGPHNH I LAVALKQA T
Sbjct: 292 PRGAMIFFRKGLKEVNKQGKE-VFYDYEDKINQAVFPGLQGGPHNHTITGLAVALKQATT 350
Query: 982 PGFKAYAQQVKANAVALGKYLMSKDYKLVTGGTENHLVLWDLRPLGLTGNKVEKLCDLAN 1161
+KAY +QV +N+ + L+ Y+LV+GGTENHLVL +L+ G+ G+KVEK+ + +
Sbjct: 351 AEYKAYQEQVMSNSAKFAETLVKSGYELVSGGTENHLVLVNLKNKGIDGSKVEKVLEAVH 410
Query: 1162 ITVNKNAVFGDSSALAPGGVRIGAPAMTSRGLVEKDFEKIGEFLHRAVTLTLKIQKEF-G 1338
I NKN V GD SA+ PGG+R+G PA+TSRG VE+DF K+ F AV L +KI+ E G
Sbjct: 411 IAANKNTVPGDVSAMVPGGIRMGTPALTSRGFVEEDFAKVAYFFDLAVKLAVKIKGEAKG 470
Query: 1339 KLLKDFNKGLVNN---KEIEELKADVEKFSASFDMPGFQMSQMKYKD 1470
LKDF + ++ EI +L+ DVE+++ F GF+ MKYK+
Sbjct: 471 TKLKDFVTAMESSAIQSEISKLRHDVEEYAKQFPTIGFEKETMKYKN 517
>sp|Q3SZ20|GLYM_BOVIN Serine hydroxymethyltransferase, mitochondrial OS=Bos
taurus GN=SHMT2 PE=2 SV=1
Length = 504
Score = 530 bits (1363), Expect = 2e-149
Identities = 274/466 (58%), Positives = 336/466 (72%), Gaps = 7/466 (1%)
Frame = +1
Query: 61 EAVNAW-GNTNLEAVDPEIHDLIEKEKRRQCRGIELIASENFTSFAVIEALGSALTNKYS 237
EA W G +L DPE+ +L+ +EK RQCRG+ELIASENF S A +EALGS L NKYS
Sbjct: 38 EASKGWSGQESLSDSDPEMWELLRREKDRQCRGLELIASENFCSRAALEALGSCLNNKYS 97
Query: 238 EGMPGNRYYGGNEYIDQIENLCRSRALQAFHLDASQWGVNVQPYSGSPANFAAYTAVLQP 417
EG PG RYYGG E +D+IE LC+ RAL+AF LD +QWGVNVQPYSGSPAN AAYTA+LQP
Sbjct: 98 EGYPGKRYYGGAEVVDEIELLCQRRALEAFDLDPAQWGVNVQPYSGSPANLAAYTALLQP 157
Query: 418 HDRIMGLDLPSGGHLTHGYYTSGGKKISATSIYFESLPYKVNSSTGYIDYDKLEEKALDF 597
HDRIMGLDLP GGHLTHG Y S K+ISATSI+FES+PYK+N TG IDYD+L A F
Sbjct: 158 HDRIMGLDLPDGGHLTHG-YMSDVKRISATSIFFESMPYKLNPQTGLIDYDQLALTARLF 216
Query: 598 RPRLIICGGSAYPRDWDYARFRAVADKCGALLLCDMAHISGLVCAQEAANPFEFCDIVTT 777
+PRLII G SAY R DYAR R V D+ A LL DMAHISGLV A+ +PF+ DIVTT
Sbjct: 217 KPRLIIAGTSAYARLIDYARMREVCDEVKAHLLADMAHISGLVAAKVIPSPFKHADIVTT 276
Query: 778 TTHKSLRGPRAGMIFYRXXXXXXXXXXXEGAEYDFEDKINFAVFPSLQGGPHNHQIGALA 957
TTHK+LRG R+G+IFYR Y FED+INFAVFPSLQGGPHNH I A+A
Sbjct: 277 TTHKTLRGARSGLIFYRKGVQAVDPKTGREIPYTFEDRINFAVFPSLQGGPHNHAIAAVA 336
Query: 958 VALKQAMTPGFKAYAQQVKANAVALGKYLMSKDYKLVTGGTENHLVLWDLRPLGLTGNKV 1137
VALKQA TP F+ Y+ Q+ NA A+ L+ + Y LV+GGT+NHLVL DLRP GL G +
Sbjct: 337 VALKQACTPMFREYSLQILKNAQAMANALLERGYSLVSGGTDNHLVLVDLRPKGLDGARA 396
Query: 1138 EKLCDLANITVNKNAVFGDSSALAPGGVRIGAPAMTSRGLVEKDFEKIGEFLHRAVTLTL 1317
E++ +L +IT NKN GD SA+ PGG+R+GAPA+TSRG +E DF K+ F+ V + L
Sbjct: 397 ERVLELVSITANKNTCPGDRSAITPGGLRLGAPALTSRGFLEDDFRKVVGFIDEGVNIGL 456
Query: 1318 KIQKEFGKLLKDFNKGLVNNKE----IEELKADVEKFSASFDMPGF 1443
+++ + K L+DF L+ + E + +L+ VE+F+ +F MPGF
Sbjct: 457 EVKSKTTK-LQDFKSFLLKDPETSHQLADLRQRVEQFARAFPMPGF 501
>sp|P49358|GLYN_FLAPR Serine hydroxymethyltransferase 2, mitochondrial
OS=Flaveria pringlei PE=2 SV=1
Length = 517
Score = 527 bits (1357), Expect = 9e-149
Identities = 271/467 (58%), Positives = 336/467 (71%), Gaps = 6/467 (1%)
Frame = +1
Query: 82 NTNLEAVDPEIHDLIEKEKRRQCRGIELIASENFTSFAVIEALGSALTNKYSEGMPGNRY 261
N LE DPEI D+IE EK RQ +G+ELI SENFTS +V++A+GS +TNKYSEG PG RY
Sbjct: 53 NAPLEVGDPEIADIIELEKARQWKGLELILSENFTSLSVMQAVGSVMTNKYSEGYPGARY 112
Query: 262 YGGNEYIDQIENLCRSRALQAFHLDASQWGVNVQPYSGSPANFAAYTAVLQPHDRIMGLD 441
YGGNEYID E LC+ RAL+AF LDA++WGVNVQP SGSPANF YTA+L+ HDRIM LD
Sbjct: 113 YGGNEYIDMAETLCQKRALEAFRLDAAKWGVNVQPLSGSPANFHVYTALLKAHDRIMALD 172
Query: 442 LPSGGHLTHGYYTSGGKKISATSIYFESLPYKVNSSTGYIDYDKLEEKALDFRPRLIICG 621
LP GGHL+HGY T KKISA SI+FE++PY++N STGYIDYD+LE+ A FRP+LI+ G
Sbjct: 173 LPHGGHLSHGYQTD-TKKISAVSIFFETMPYRLNESTGYIDYDQLEKSATLFRPKLIVAG 231
Query: 622 GSAYPRDWDYARFRAVADKCGALLLCDMAHISGLVCAQEAANPFEFCDIVTTTTHKSLRG 801
SAY R +DYAR R V DK A+LL DMAHISGLV A +PF++ D+VTTTTHKSLRG
Sbjct: 232 ASAYARLYDYARIRKVCDKQKAILLADMAHISGLVAAGVIPSPFDYADVVTTTTHKSLRG 291
Query: 802 PRAGMIFYRXXXXXXXXXXXEGAEYDFEDKINFAVFPSLQGGPHNHQIGALAVALKQAMT 981
PR MIF+R E YD+EDKIN AVFP LQGGPHNH I LAVALKQA T
Sbjct: 292 PRGAMIFFRKGVKEVNKQGKE-VLYDYEDKINQAVFPGLQGGPHNHTITGLAVALKQATT 350
Query: 982 PGFKAYAQQVKANAVALGKYLMSKDYKLVTGGTENHLVLWDLRPLGLTGNKVEKLCDLAN 1161
+KAY +QV +N + L+ Y+LV+GGTENHLVL +L+ G+ G++VEK+ + +
Sbjct: 351 AEYKAYQEQVMSNCAKFAETLVKSGYELVSGGTENHLVLVNLKNKGIDGSRVEKVLEAVH 410
Query: 1162 ITVNKNAVFGDSSALAPGGVRIGAPAMTSRGLVEKDFEKIGEFLHRAVTLTLKIQKEF-G 1338
I NKN V GD SA+ PGG+R+G PA+TSRG VE+DF K+ AV L +KI+ E G
Sbjct: 411 IAANKNTVPGDVSAMVPGGIRMGTPALTSRGFVEEDFAKVAYLFDLAVKLAVKIKGEAQG 470
Query: 1339 KLLKDFNKGLVNN---KEIEELKADVEKFSASFDMPGFQMSQMKYKD 1470
LKDF + ++ EI +L+ DVE+++ F GF+ MKYK+
Sbjct: 471 TKLKDFVAAMQSSAFQSEISKLRHDVEEYAKQFPTIGFEKETMKYKN 517
>sp|P50433|GLYM_SOLTU Serine hydroxymethyltransferase, mitochondrial OS=Solanum
tuberosum PE=2 SV=1
Length = 518
Score = 526 bits (1354), Expect = 2e-148
Identities = 267/468 (57%), Positives = 340/468 (72%), Gaps = 7/468 (1%)
Frame = +1
Query: 82 NTNLEAVDPEIHDLIEKEKRRQCRGIELIASENFTSFAVIEALGSALTNKYSEGMPGNRY 261
N LE VDPEI D+IE EK RQ +G+ELI SENFTS +V++A+GS +TNKYSEG PG RY
Sbjct: 53 NAPLEVVDPEIADIIEHEKARQWKGLELIPSENFTSVSVMQAVGSVMTNKYSEGYPGARY 112
Query: 262 YGGNEYIDQIENLCRSRALQAFHLDASQWGVNVQPYSGSPANFAAYTAVLQPHDRIMGLD 441
YGGNEYID E LC+ RAL+AF LD ++WGVNVQP SGSPANF YTA+L+PH+RIM LD
Sbjct: 113 YGGNEYIDMAETLCQKRALEAFRLDPAKWGVNVQPLSGSPANFQVYTALLKPHERIMALD 172
Query: 442 LPSGGHLTHGYYTSGGKKISATSIYFESLPYKVNSSTGYIDYDKLEEKALDFRPRLIICG 621
LP GGHL+HGY T KKISA SI+FE++PY+++ STGYIDYD+LE+ A FRP+LI+ G
Sbjct: 173 LPHGGHLSHGYQTD-TKKISAVSIFFETMPYRLDESTGYIDYDQLEKSATLFRPKLIVAG 231
Query: 622 GSAYPRDWDYARFRAVADKCGALLLCDMAHISGLVCAQEAANPFEFCDIVTTTTHKSLRG 801
SAY R +DY R R V +K A+LL DMAHISGLV A +PF++ D+VTTTTHKSLRG
Sbjct: 232 ASAYARLYDYDRIRKVCNKQKAILLADMAHISGLVAAGVIPSPFDYADVVTTTTHKSLRG 291
Query: 802 PRAGMIFYRXXXXXXXXXXXEGAEYDFEDKINFAVFPSLQGGPHNHQIGALAVALKQAMT 981
PR MIFYR E YD+EDKIN AVFP LQGGPHNH I LAVALKQA T
Sbjct: 292 PRGAMIFYRKGVKEVNKQGKE-VFYDYEDKINQAVFPGLQGGPHNHTITGLAVALKQATT 350
Query: 982 PGFKAYAQQVKANAVALGKYLMSKDYKLVTGGTENHLVLWDLRPLGLTGNKVEKLCDLAN 1161
P ++AY +QV +N+ + L K Y+LV+GGT+NHLVL +++ G+ G++VEK+ + +
Sbjct: 351 PEYRAYQEQVLSNSSKFAQALGEKGYELVSGGTDNHLVLVNMKNKGIDGSRVEKVLEAVH 410
Query: 1162 ITVNKNAVFGDSSALAPGGVRIGAPAMTSRGLVEKDFEKIGEFLHRAVTLTLKIQKEF-G 1338
I NKN V GD SA+ PGG+R+G PA+TSRG +E+DF K+ +F AV + +K++ E G
Sbjct: 411 IAANKNTVPGDVSAMVPGGIRMGTPALTSRGFLEEDFVKVADFFDAAVKIAVKVKAETQG 470
Query: 1339 KLLKDFNKGLVNN----KEIEELKADVEKFSASFDMPGFQMSQMKYKD 1470
LKDF L ++ EI +L+ DVE+++ F GF+ MKYK+
Sbjct: 471 TKLKDFVATLESSAPIKSEIAKLRHDVEEYAKQFPTIGFEKETMKYKN 518
>sp|P14519|GLYM_RABIT Serine hydroxymethyltransferase, mitochondrial
OS=Oryctolagus cuniculus GN=SHMT2 PE=1 SV=2
Length = 504
Score = 524 bits (1349), Expect = 8e-148
Identities = 269/466 (57%), Positives = 337/466 (72%), Gaps = 7/466 (1%)
Frame = +1
Query: 61 EAVNAW-GNTNLEAVDPEIHDLIEKEKRRQCRGIELIASENFTSFAVIEALGSALTNKYS 237
EA W G +L DPE+ +L+++EK RQCRG+ELIASENF A +EALGS L NKYS
Sbjct: 38 EASRGWTGQESLSDTDPEMWELLQREKDRQCRGLELIASENFCIRAALEALGSCLNNKYS 97
Query: 238 EGMPGNRYYGGNEYIDQIENLCRSRALQAFHLDASQWGVNVQPYSGSPANFAAYTAVLQP 417
EG PG RYYGG E +D+IE LC+ RAL+AF LD +QWGVNVQPYSGSPAN AAYTA+LQP
Sbjct: 98 EGYPGKRYYGGAEVVDEIELLCQRRALEAFDLDPAQWGVNVQPYSGSPANLAAYTALLQP 157
Query: 418 HDRIMGLDLPSGGHLTHGYYTSGGKKISATSIYFESLPYKVNSSTGYIDYDKLEEKALDF 597
HDRIMGLDLP GGHLTHG Y S K++SATSI+FES+PYK+N TG IDY++L A F
Sbjct: 158 HDRIMGLDLPDGGHLTHG-YMSDVKRVSATSIFFESMPYKLNPQTGLIDYEQLALTARLF 216
Query: 598 RPRLIICGGSAYPRDWDYARFRAVADKCGALLLCDMAHISGLVCAQEAANPFEFCDIVTT 777
RPRLII G SAY R DYAR R V D+ A LL DMAHISGLV A+ +PF+ D+VTT
Sbjct: 217 RPRLIIAGTSAYARLIDYARMREVCDEVKAHLLADMAHISGLVAAKVIPSPFKHADVVTT 276
Query: 778 TTHKSLRGPRAGMIFYRXXXXXXXXXXXEGAEYDFEDKINFAVFPSLQGGPHNHQIGALA 957
TTHK+LRG R+G+IFYR + Y FED+INFAVFPSLQGGPHNH I A+A
Sbjct: 277 TTHKTLRGARSGLIFYRKGVRTVDPKTGQEIPYTFEDRINFAVFPSLQGGPHNHAIAAVA 336
Query: 958 VALKQAMTPGFKAYAQQVKANAVALGKYLMSKDYKLVTGGTENHLVLWDLRPLGLTGNKV 1137
VALKQA TP F+ Y+ QV NA A+ L+ + Y LV+GGT+NHLVL DLRP GL G +
Sbjct: 337 VALKQACTPMFREYSLQVLKNARAMADALLERGYSLVSGGTDNHLVLVDLRPKGLDGARA 396
Query: 1138 EKLCDLANITVNKNAVFGDSSALAPGGVRIGAPAMTSRGLVEKDFEKIGEFLHRAVTLTL 1317
E++ +L +IT NKN GD SA+ PGG+R+GAPA+TSR E DF ++ +F+ V + L
Sbjct: 397 ERVLELVSITANKNTCPGDRSAITPGGLRLGAPALTSRQFREDDFRRVVDFIDEGVNIGL 456
Query: 1318 KIQKEFGKLLKDFNKGLVNNKE----IEELKADVEKFSASFDMPGF 1443
+++++ K L+DF L+ + E + +L+ V++F+ +F MPGF
Sbjct: 457 EVKRKTAK-LQDFKSFLLKDPETSQHLADLRRRVQQFARAFPMPGF 501
>sp|P34897|GLYM_HUMAN Serine hydroxymethyltransferase, mitochondrial OS=Homo
sapiens GN=SHMT2 PE=1 SV=3
Length = 504
Score = 523 bits (1347), Expect = 1e-147
Identities = 272/466 (58%), Positives = 334/466 (71%), Gaps = 7/466 (1%)
Frame = +1
Query: 61 EAVNAW-GNTNLEAVDPEIHDLIEKEKRRQCRGIELIASENFTSFAVIEALGSALTNKYS 237
EA W G +L DPE+ +L+++EK RQCRG+ELIASENF S A +EALGS L NKYS
Sbjct: 38 EANRGWTGQESLSDSDPEMWELLQREKDRQCRGLELIASENFCSRAALEALGSCLNNKYS 97
Query: 238 EGMPGNRYYGGNEYIDQIENLCRSRALQAFHLDASQWGVNVQPYSGSPANFAAYTAVLQP 417
EG PG RYYGG E +D+IE LC+ RAL+AF LD +QWGVNVQPYSGSPAN A YTA+LQP
Sbjct: 98 EGYPGKRYYGGAEVVDEIELLCQRRALEAFDLDPAQWGVNVQPYSGSPANLAVYTALLQP 157
Query: 418 HDRIMGLDLPSGGHLTHGYYTSGGKKISATSIYFESLPYKVNSSTGYIDYDKLEEKALDF 597
HDRIMGLDLP GGHLTHG Y S K+ISATSI+FES+PYK+N TG IDY++L A F
Sbjct: 158 HDRIMGLDLPDGGHLTHG-YMSDVKRISATSIFFESMPYKLNPKTGLIDYNQLALTARLF 216
Query: 598 RPRLIICGGSAYPRDWDYARFRAVADKCGALLLCDMAHISGLVCAQEAANPFEFCDIVTT 777
RPRLII G SAY R DYAR R V D+ A LL DMAHISGLV A+ +PF+ DIVTT
Sbjct: 217 RPRLIIAGTSAYARLIDYARMREVCDEVKAHLLADMAHISGLVAAKVIPSPFKHADIVTT 276
Query: 778 TTHKSLRGPRAGMIFYRXXXXXXXXXXXEGAEYDFEDKINFAVFPSLQGGPHNHQIGALA 957
TTHK+LRG R+G+IFYR Y FED+INFAVFPSLQGGPHNH I A+A
Sbjct: 277 TTHKTLRGARSGLIFYRKGVKAVDPKTGREIPYTFEDRINFAVFPSLQGGPHNHAIAAVA 336
Query: 958 VALKQAMTPGFKAYAQQVKANAVALGKYLMSKDYKLVTGGTENHLVLWDLRPLGLTGNKV 1137
VALKQA TP F+ Y+ QV NA A+ L+ + Y LV+GGT+NHLVL DLRP GL G +
Sbjct: 337 VALKQACTPMFREYSLQVLKNARAMADALLERGYSLVSGGTDNHLVLVDLRPKGLDGARA 396
Query: 1138 EKLCDLANITVNKNAVFGDSSALAPGGVRIGAPAMTSRGLVEKDFEKIGEFLHRAVTLTL 1317
E++ +L +IT NKN GD SA+ PGG+R+GAPA+TSR E DF ++ +F+ V + L
Sbjct: 397 ERVLELVSITANKNTCPGDRSAITPGGLRLGAPALTSRQFREDDFRRVVDFIDEGVNIGL 456
Query: 1318 KIQKEFGKLLKDFNKGLVNNKE----IEELKADVEKFSASFDMPGF 1443
+++ + K L+DF L+ + E + L+ VE+F+ +F MPGF
Sbjct: 457 EVKSKTAK-LQDFKSFLLKDSETSQRLANLRQRVEQFARAFPMPGF 501
>sp|P50432|GLYC_CAEEL Serine hydroxymethyltransferase OS=Caenorhabditis elegans
GN=mel-32 PE=1 SV=2
Length = 507
Score = 522 bits (1342), Expect = 5e-147
Identities = 260/455 (57%), Positives = 327/455 (71%), Gaps = 6/455 (1%)
Frame = +1
Query: 88 NLEAVDPEIHDLIEKEKRRQCRGIELIASENFTSFAVIEALGSALTNKYSEGMPGNRYYG 267
++E VDPE+ D+++ EK+RQ RG+ELIASENFTS AV++ALGSA+ NKYSEG PG RYYG
Sbjct: 51 HVEKVDPEVFDIMKNEKKRQRRGLELIASENFTSKAVMDALGSAMCNKYSEGYPGARYYG 110
Query: 268 GNEYIDQIENLCRSRALQAFHLDASQWGVNVQPYSGSPANFAAYTAVLQPHDRIMGLDLP 447
GNE+IDQ+E LC+ RAL+ F LD ++WGVNVQP SGSPANFA YTA++ + RIMGLDLP
Sbjct: 111 GNEFIDQMELLCQKRALEVFGLDPAKWGVNVQPLSGSPANFAVYTAIVGSNGRIMGLDLP 170
Query: 448 SGGHLTHGYYTSGGKKISATSIYFESLPYKVNSSTGYIDYDKLEEKALDFRPRLIICGGS 627
GGHLTHG++T +K+SATS +F+SLPYKV+ +TG IDYDKLE+ A+ FRP+ II G S
Sbjct: 171 DGGHLTHGFFTP-ARKVSATSEFFQSLPYKVDPTTGLIDYDKLEQNAMLFRPKAIIAGVS 229
Query: 628 AYPRDWDYARFRAVADKCGALLLCDMAHISGLVCAQEAANPFEFCDIVTTTTHKSLRGPR 807
Y R DY RFR +A K GA L+ DMAHISGLV A +PFE+ D+VTTTTHKSLRGPR
Sbjct: 230 CYARHLDYERFRKIATKAGAYLMSDMAHISGLVAAGLIPSPFEYSDVVTTTTHKSLRGPR 289
Query: 808 AGMIFYRXXXXXXXXXXXEGAEYDFEDKINFAVFPSLQGGPHNHQIGALAVALKQAMTPG 987
+IFYR + YD E+KIN AVFP LQGGPHNH I +AVAL+Q ++
Sbjct: 290 GALIFYRKGVRSTNAKGVD-TLYDLEEKINSAVFPGLQGGPHNHTIAGIAVALRQCLSED 348
Query: 988 FKAYAQQVKANAVALGKYLMSKDYKLVTGGTENHLVLWDLRPLGLTGNKVEKLCDLANIT 1167
F Y +QV NA L + + Y L TGGT+NHL+L DLRP+G+ G + E + DLA+I
Sbjct: 349 FVQYGEQVLKNAKTLAERMKKHGYALATGGTDNHLLLVDLRPIGVEGARAEHVLDLAHIA 408
Query: 1168 VNKNAVFGDSSALAPGGVRIGAPAMTSRGLVEKDFEKIGEFLHRAVTLTLKIQKEFGKLL 1347
NKN GD SAL PGG+R+G PA+TSRG E+DFEK+G+F+H V + K E GK L
Sbjct: 409 CNKNTCPGDVSALRPGGIRLGTPALTSRGFQEQDFEKVGDFIHEGVQIAKKYNAEAGKTL 468
Query: 1348 KDFNKGLVNN----KEIEELKADVEKFSASFDMPG 1440
KDF N K++ +L VE+FS F++PG
Sbjct: 469 KDFKSFTETNEPFKKDVADLAKRVEEFSTKFEIPG 503
>sp|P07511|GLYC_RABIT Serine hydroxymethyltransferase, cytosolic OS=Oryctolagus
cuniculus GN=SHMT1 PE=1 SV=2
Length = 484
Score = 522 bits (1342), Expect = 5e-147
Identities = 265/456 (58%), Positives = 326/456 (71%), Gaps = 7/456 (1%)
Frame = +1
Query: 91 LEAVDPEIHDLIEKEKRRQCRGIELIASENFTSFAVIEALGSALTNKYSEGMPGNRYYGG 270
L+ D E++D+I+KE RQ G+ELIASENF S AV+EALGS L NKYSEG PG RYYGG
Sbjct: 26 LKDSDAEVYDIIKKESNRQRVGLELIASENFASRAVLEALGSCLNNKYSEGYPGQRYYGG 85
Query: 271 NEYIDQIENLCRSRALQAFHLDASQWGVNVQPYSGSPANFAAYTAVLQPHDRIMGLDLPS 450
E+ID++E LC+ RALQA+ LD WGVNVQPYSGSPANFA YTA+++PH RIMGLDLP
Sbjct: 86 TEHIDELETLCQKRALQAYGLDPQCWGVNVQPYSGSPANFAVYTALVEPHGRIMGLDLPD 145
Query: 451 GGHLTHGYYTSGGKKISATSIYFESLPYKVNSSTGYIDYDKLEEKALDFRPRLIICGGSA 630
GGHLTHG+ T KKISATSI+FES+ YKVN TGYIDYD+LEE A F P+LII G S
Sbjct: 146 GGHLTHGFMTD-KKKISATSIFFESMAYKVNPDTGYIDYDRLEENARLFHPKLIIAGTSC 204
Query: 631 YPRDWDYARFRAVADKCGALLLCDMAHISGLVCAQEAANPFEFCDIVTTTTHKSLRGPRA 810
Y R+ DY R R +AD+ GA L+ DMAHISGLV A +PFE C +VTTTTHK+LRG RA
Sbjct: 205 YSRNLDYGRLRKIADENGAYLMADMAHISGLVVAGVVPSPFEHCHVVTTTTHKTLRGCRA 264
Query: 811 GMIFYRXXXXXXXXXXXEGAEYDFEDKINFAVFPSLQGGPHNHQIGALAVALKQAMTPGF 990
GMIFYR + Y+ E IN AVFP LQGGPHNH I +AVALKQAMTP F
Sbjct: 265 GMIFYRRGVRSVDPKTGKEILYNLESLINSAVFPGLQGGPHNHAIAGVAVALKQAMTPEF 324
Query: 991 KAYAQQVKANAVALGKYLMSKDYKLVTGGTENHLVLWDLRPLGLTGNKVEKLCDLANITV 1170
K Y +QV AN AL L+ YK+VTGG++NHL+L DLR G G + EK+ + +I
Sbjct: 325 KEYQRQVVANCRALSAALVELGYKIVTGGSDNHLILVDLRSKGTDGGRAEKVLEACSIAC 384
Query: 1171 NKNAVFGDSSALAPGGVRIGAPAMTSRGLVEKDFEKIGEFLHRAVTLTLKIQKEFG--KL 1344
NKN GD SAL P G+R+G PA+TSRGL+EKDF+K+ F+HR + LT++IQ + G
Sbjct: 385 NKNTCPGDKSALRPSGLRLGTPALTSRGLLEKDFQKVAHFIHRGIELTVQIQDDTGPRAT 444
Query: 1345 LKDFNKGLVNNKE----IEELKADVEKFSASFDMPG 1440
LK+F + L +++ + L+ +VE F+A F +PG
Sbjct: 445 LKEFKEKLAGDEKHQRAVRALRQEVESFAALFPLPG 480
>sp|Q5RFK5|GLYC_PONAB Serine hydroxymethyltransferase, cytosolic OS=Pongo abelii
GN=SHMT1 PE=2 SV=1
Length = 483
Score = 520 bits (1339), Expect = 1e-146
Identities = 265/455 (58%), Positives = 325/455 (71%), Gaps = 6/455 (1%)
Frame = +1
Query: 91 LEAVDPEIHDLIEKEKRRQCRGIELIASENFTSFAVIEALGSALTNKYSEGMPGNRYYGG 270
L+ D E++++I+KE RQ G+EL ASENF S AV+EALGS L NKYSEG PG RYYGG
Sbjct: 26 LKDSDVEVYNIIKKESNRQRVGLELFASENFASQAVLEALGSCLNNKYSEGYPGQRYYGG 85
Query: 271 NEYIDQIENLCRSRALQAFHLDASQWGVNVQPYSGSPANFAAYTAVLQPHDRIMGLDLPS 450
E+ID++E LC+ RALQA+ LD WGVNVQPYSGSPANFA YTA+++PH RIMGLDLP
Sbjct: 86 TEFIDELETLCQKRALQAYKLDPQCWGVNVQPYSGSPANFAVYTALVEPHGRIMGLDLPD 145
Query: 451 GGHLTHGYYTSGGKKISATSIYFESLPYKVNSSTGYIDYDKLEEKALDFRPRLIICGGSA 630
GGHLTHG+ T G KKISATSI+FES+PYKVN TGYI+YD+LEE A F P+LII G S
Sbjct: 146 GGHLTHGFMT-GKKKISATSIFFESMPYKVNPDTGYINYDQLEENARLFHPKLIIAGTSC 204
Query: 631 YPRDWDYARFRAVADKCGALLLCDMAHISGLVCAQEAANPFEFCDIVTTTTHKSLRGPRA 810
Y R+ DYAR R +AD+ GA L+ DMAHISGLV A +PFE C +VTTTTHK+LRG RA
Sbjct: 205 YSRNLDYARLRKIADENGAYLMADMAHISGLVAAGVVPSPFEHCHVVTTTTHKTLRGCRA 264
Query: 811 GMIFYRXXXXXXXXXXXEGAEYDFEDKINFAVFPSLQGGPHNHQIGALAVALKQAMTPGF 990
GMIFYR + Y+ E IN AVFP LQGGPHNH I +AVALKQAMT F
Sbjct: 265 GMIFYRKGVQSVDPKTGKEILYNLESLINSAVFPGLQGGPHNHAIAGVAVALKQAMTLEF 324
Query: 991 KAYAQQVKANAVALGKYLMSKDYKLVTGGTENHLVLWDLRPLGLTGNKVEKLCDLANITV 1170
K Y QV AN AL + L YK+VTGG++NHL+L DLR G G + EK+ + +I
Sbjct: 325 KVYQHQVVANCRALSEALTELGYKIVTGGSDNHLILVDLRSKGTDGGRAEKVLEACSIAC 384
Query: 1171 NKNAVFGDSSALAPGGVRIGAPAMTSRGLVEKDFEKIGEFLHRAVTLTLKIQKEFG--KL 1344
NKN GD SAL P G+R+G PA+TSRGL+EKDF+K+ F+HR + LTL+IQ + G
Sbjct: 385 NKNTCPGDRSALRPSGLRLGTPALTSRGLLEKDFQKVAHFIHRGIELTLQIQSDTGVRAT 444
Query: 1345 LKDFNKGLVNNK---EIEELKADVEKFSASFDMPG 1440
LK+F + L +K ++ L+ VE F++ F +PG
Sbjct: 445 LKEFKERLAGDKYQGAVQALREKVESFASLFPLPG 479
>sp|Q5E9P9|GLYC_BOVIN Serine hydroxymethyltransferase, cytosolic OS=Bos taurus
GN=SHMT1 PE=2 SV=3
Length = 484
Score = 520 bits (1337), Expect = 2e-146
Identities = 263/452 (58%), Positives = 324/452 (71%), Gaps = 7/452 (1%)
Frame = +1
Query: 103 DPEIHDLIEKEKRRQCRGIELIASENFTSFAVIEALGSALTNKYSEGMPGNRYYGGNEYI 282
D E++++I+KE RQ G+ELIASENF S AV+EALGS L NKYSEG PG RYYGG E+I
Sbjct: 30 DVEVYNIIKKESNRQRVGLELIASENFASRAVLEALGSCLNNKYSEGYPGQRYYGGTEFI 89
Query: 283 DQIENLCRSRALQAFHLDASQWGVNVQPYSGSPANFAAYTAVLQPHDRIMGLDLPSGGHL 462
D++E LC+ RALQ + LD+ WGVNVQPYSGSPANFA YTA+++PH RIMGLDLP GGHL
Sbjct: 90 DELEVLCQKRALQVYGLDSQCWGVNVQPYSGSPANFAVYTALVEPHGRIMGLDLPDGGHL 149
Query: 463 THGYYTSGGKKISATSIYFESLPYKVNSSTGYIDYDKLEEKALDFRPRLIICGGSAYPRD 642
THG+ T KKISATSI+FES+PYKVN TGYI+YD+LEE A F PRLII G S Y R+
Sbjct: 150 THGFMTD-KKKISATSIFFESMPYKVNPDTGYINYDQLEENARLFHPRLIIAGTSCYSRN 208
Query: 643 WDYARFRAVADKCGALLLCDMAHISGLVCAQEAANPFEFCDIVTTTTHKSLRGPRAGMIF 822
DYAR R +AD GA L+ DMAH+SGLV A +PFE C +V+TTTHK+LRG RAGMIF
Sbjct: 209 LDYARLRKIADDNGAYLMADMAHVSGLVAAGVVPSPFEHCHVVSTTTHKTLRGCRAGMIF 268
Query: 823 YRXXXXXXXXXXXEGAEYDFEDKINFAVFPSLQGGPHNHQIGALAVALKQAMTPGFKAYA 1002
YR Y+ E IN AVFP LQGGPHNH I +AVALKQAMTP F+AY
Sbjct: 269 YRKGVRSVDPKTGRETRYNLESLINSAVFPGLQGGPHNHAIAGVAVALKQAMTPEFRAYQ 328
Query: 1003 QQVKANAVALGKYLMSKDYKLVTGGTENHLVLWDLRPLGLTGNKVEKLCDLANITVNKNA 1182
+QV AN AL + LM Y++VTGG++NHL+L DLR G G + EK+ + +I NKN
Sbjct: 329 RQVVANCRALAEALMGLGYRVVTGGSDNHLILVDLRSKGTDGGRAEKVLEACSIACNKNT 388
Query: 1183 VFGDSSALAPGGVRIGAPAMTSRGLVEKDFEKIGEFLHRAVTLTLKIQKEFG--KLLKDF 1356
GD SAL P G+R+G PA+TSRGL+E+DF+K+ F+HR + LTL+IQ G LK+F
Sbjct: 389 CPGDKSALRPSGLRLGTPALTSRGLLEEDFQKVAHFIHRGIELTLQIQDAVGVKATLKEF 448
Query: 1357 NKGLVNNKE----IEELKADVEKFSASFDMPG 1440
+ L +E + L+A+VE F+ F +PG
Sbjct: 449 MEKLAGAEEHHRAVAALRAEVESFATLFPLPG 480
>sp|P34896|GLYC_HUMAN Serine hydroxymethyltransferase, cytosolic OS=Homo sapiens
GN=SHMT1 PE=1 SV=1
Length = 483
Score = 519 bits (1336), Expect = 3e-146
Identities = 264/455 (58%), Positives = 326/455 (71%), Gaps = 6/455 (1%)
Frame = +1
Query: 91 LEAVDPEIHDLIEKEKRRQCRGIELIASENFTSFAVIEALGSALTNKYSEGMPGNRYYGG 270
L+ D E++++I+KE RQ G+ELIASENF S AV+EALGS L NKYSEG PG RYYGG
Sbjct: 26 LKDSDVEVYNIIKKESNRQRVGLELIASENFASRAVLEALGSCLNNKYSEGYPGQRYYGG 85
Query: 271 NEYIDQIENLCRSRALQAFHLDASQWGVNVQPYSGSPANFAAYTAVLQPHDRIMGLDLPS 450
E+ID++E LC+ RALQA+ LD WGVNVQPYSGSPANFA YTA+++PH RIMGLDLP
Sbjct: 86 TEFIDELETLCQKRALQAYKLDPQCWGVNVQPYSGSPANFAVYTALVEPHGRIMGLDLPD 145
Query: 451 GGHLTHGYYTSGGKKISATSIYFESLPYKVNSSTGYIDYDKLEEKALDFRPRLIICGGSA 630
GGHLTHG+ T KKISATSI+FES+PYKVN TGYI+YD+LEE A F P+LII G S
Sbjct: 146 GGHLTHGFMTD-KKKISATSIFFESMPYKVNPDTGYINYDQLEENARLFHPKLIIAGTSC 204
Query: 631 YPRDWDYARFRAVADKCGALLLCDMAHISGLVCAQEAANPFEFCDIVTTTTHKSLRGPRA 810
Y R+ +YAR R +AD+ GA L+ DMAHISGLV A +PFE C +VTTTTHK+LRG RA
Sbjct: 205 YSRNLEYARLRKIADENGAYLMADMAHISGLVAAGVVPSPFEHCHVVTTTTHKTLRGCRA 264
Query: 811 GMIFYRXXXXXXXXXXXEGAEYDFEDKINFAVFPSLQGGPHNHQIGALAVALKQAMTPGF 990
GMIFYR + Y+ E IN AVFP LQGGPHNH I +AVALKQAMT F
Sbjct: 265 GMIFYRKGVKSVDPKTGKEILYNLESLINSAVFPGLQGGPHNHAIAGVAVALKQAMTLEF 324
Query: 991 KAYAQQVKANAVALGKYLMSKDYKLVTGGTENHLVLWDLRPLGLTGNKVEKLCDLANITV 1170
K Y QV AN AL + L YK+VTGG++NHL+L DLR G G + EK+ + +I
Sbjct: 325 KVYQHQVVANCRALSEALTELGYKIVTGGSDNHLILVDLRSKGTDGGRAEKVLEACSIAC 384
Query: 1171 NKNAVFGDSSALAPGGVRIGAPAMTSRGLVEKDFEKIGEFLHRAVTLTLKIQKEFG--KL 1344
NKN GD SAL P G+R+G PA+TSRGL+EKDF+K+ F+HR + LTL+IQ + G
Sbjct: 385 NKNTCPGDRSALRPSGLRLGTPALTSRGLLEKDFQKVAHFIHRGIELTLQIQSDTGVRAT 444
Query: 1345 LKDFNKGLVNNK---EIEELKADVEKFSASFDMPG 1440
LK+F + L +K ++ L+ +VE F++ F +PG
Sbjct: 445 LKEFKERLAGDKYQAAVQALREEVESFASLFPLPG 479
>sp|Q60V73|GLYC_CAEBR Serine hydroxymethyltransferase OS=Caenorhabditis briggsae
GN=mel-32 PE=3 SV=2
Length = 484
Score = 519 bits (1335), Expect = 3e-146
Identities = 259/455 (56%), Positives = 326/455 (71%), Gaps = 6/455 (1%)
Frame = +1
Query: 88 NLEAVDPEIHDLIEKEKRRQCRGIELIASENFTSFAVIEALGSALTNKYSEGMPGNRYYG 267
++E +DPE+ ++++ EK RQ RG+ELIASENFTS AV++ALGSA+ NKYSEG PG RYYG
Sbjct: 28 HVEKIDPEVFNIMKNEKSRQRRGLELIASENFTSKAVMDALGSAMCNKYSEGYPGARYYG 87
Query: 268 GNEYIDQIENLCRSRALQAFHLDASQWGVNVQPYSGSPANFAAYTAVLQPHDRIMGLDLP 447
GNE+IDQ+E LC+ RAL+ F LD ++WGVNVQ SGSPANFA YTA++ + RIMGLDLP
Sbjct: 88 GNEFIDQMEILCQKRALEVFGLDPAKWGVNVQSLSGSPANFAVYTALVGANGRIMGLDLP 147
Query: 448 SGGHLTHGYYTSGGKKISATSIYFESLPYKVNSSTGYIDYDKLEEKALDFRPRLIICGGS 627
GGHLTHG++T +K+SATS +F+S+PYKV++ +G IDYDKLEE A+ FRP+++I G S
Sbjct: 148 DGGHLTHGFFTP-ARKVSATSEFFQSMPYKVDAQSGLIDYDKLEENAMLFRPKVLIAGVS 206
Query: 628 AYPRDWDYARFRAVADKCGALLLCDMAHISGLVCAQEAANPFEFCDIVTTTTHKSLRGPR 807
Y R DY RFR +A K GA L+ DMAHISGLV A +PFE+ D+VTTTTHKSLRGPR
Sbjct: 207 CYARHLDYERFRKIATKAGAYLMSDMAHISGLVAAGLIPSPFEYSDVVTTTTHKSLRGPR 266
Query: 808 AGMIFYRXXXXXXXXXXXEGAEYDFEDKINFAVFPSLQGGPHNHQIGALAVALKQAMTPG 987
MIFYR E YD E+KIN AVFP LQGGPHNH I +AVALKQ ++
Sbjct: 267 GAMIFYRKGVRSVNAKGVE-TLYDLEEKINSAVFPGLQGGPHNHTIAGIAVALKQCLSED 325
Query: 988 FKAYAQQVKANAVALGKYLMSKDYKLVTGGTENHLVLWDLRPLGLTGNKVEKLCDLANIT 1167
F Y +Q+ NA L + L Y L TGGT+NHL+L DLRP+G+ G + E + DLA+I
Sbjct: 326 FVQYGEQILKNAKTLAERLKKHGYSLATGGTDNHLLLVDLRPIGVEGARAEHILDLAHIA 385
Query: 1168 VNKNAVFGDSSALAPGGVRIGAPAMTSRGLVEKDFEKIGEFLHRAVTLTLKIQKEFGKLL 1347
NKN GD SAL PGG+R+G PA+TSRG E+DFEK+G+F+H V + K E GK L
Sbjct: 386 CNKNTCPGDVSALRPGGIRLGTPALTSRGFKEQDFEKVGDFIHEGVQIAKKYNAEAGKTL 445
Query: 1348 KDFNKGLVNN----KEIEELKADVEKFSASFDMPG 1440
KDF N +E+ EL VE+FS F++PG
Sbjct: 446 KDFKAFTATNEQFKQEVAELAKRVEEFSGKFEIPG 480
>sp|P35623|GLYC_SHEEP Serine hydroxymethyltransferase, cytosolic OS=Ovis aries
GN=SHMT1 PE=1 SV=3
Length = 484
Score = 519 bits (1335), Expect = 3e-146
Identities = 264/452 (58%), Positives = 323/452 (71%), Gaps = 7/452 (1%)
Frame = +1
Query: 103 DPEIHDLIEKEKRRQCRGIELIASENFTSFAVIEALGSALTNKYSEGMPGNRYYGGNEYI 282
D E++++I+KE RQ G+ELIASENF S AV+EALGS L NKYSEG PG RYYGG E+I
Sbjct: 30 DVEVYNIIKKESNRQRVGLELIASENFASRAVLEALGSCLNNKYSEGYPGQRYYGGTEFI 89
Query: 283 DQIENLCRSRALQAFHLDASQWGVNVQPYSGSPANFAAYTAVLQPHDRIMGLDLPSGGHL 462
D++E LC+ RALQ + LD WGVNVQPYSGSPANFA YTA+++PH RIMGLDLP GGHL
Sbjct: 90 DELEVLCQKRALQVYGLDPECWGVNVQPYSGSPANFAVYTALVEPHGRIMGLDLPDGGHL 149
Query: 463 THGYYTSGGKKISATSIYFESLPYKVNSSTGYIDYDKLEEKALDFRPRLIICGGSAYPRD 642
THG+ T KKISATSI+FES+PYKVN TGYI+YD+LEE A F PRLII G S Y R+
Sbjct: 150 THGFMTD-KKKISATSIFFESMPYKVNPDTGYINYDQLEENARLFHPRLIIAGTSCYSRN 208
Query: 643 WDYARFRAVADKCGALLLCDMAHISGLVCAQEAANPFEFCDIVTTTTHKSLRGPRAGMIF 822
DYAR R +AD GA L+ DMAHISGLV A +PFE C +V+TTTHK+LRG RAGMIF
Sbjct: 209 LDYARLRKIADDNGAYLMADMAHISGLVAAGVVPSPFEHCHVVSTTTHKTLRGCRAGMIF 268
Query: 823 YRXXXXXXXXXXXEGAEYDFEDKINFAVFPSLQGGPHNHQIGALAVALKQAMTPGFKAYA 1002
YR + Y+ E IN AVFP LQGGPHNH I +AVALKQAMTP F+AY
Sbjct: 269 YRKGVRSVDPKTGKETRYNLESLINSAVFPGLQGGPHNHAIAGVAVALKQAMTPEFRAYQ 328
Query: 1003 QQVKANAVALGKYLMSKDYKLVTGGTENHLVLWDLRPLGLTGNKVEKLCDLANITVNKNA 1182
+QV AN AL + LM Y++VTGG++NHL+L DLR G G + EK+ + +I NKN
Sbjct: 329 RQVVANCRALAEALMGLGYRVVTGGSDNHLILVDLRSKGTDGGRAEKVLEACSIACNKNT 388
Query: 1183 VFGDSSALAPGGVRIGAPAMTSRGLVEKDFEKIGEFLHRAVTLTLKIQKEFG--KLLKDF 1356
GD SAL P G+R+G PA+TSRGL+E+DF K+ F+HR + LTL+IQ G LK+F
Sbjct: 389 CPGDKSALRPSGLRLGTPALTSRGLLEEDFRKVAHFIHRGIELTLQIQDAVGVKATLKEF 448
Query: 1357 NKGLVNNKE----IEELKADVEKFSASFDMPG 1440
+ L +E + L+A+VE F+ F +PG
Sbjct: 449 MEKLAGAEEHQRAVTALRAEVESFATLFPLPG 480
>sp|P50431|GLYC_MOUSE Serine hydroxymethyltransferase, cytosolic OS=Mus musculus
GN=Shmt1 PE=1 SV=2
Length = 478
Score = 518 bits (1334), Expect = 4e-146
Identities = 263/456 (57%), Positives = 324/456 (71%), Gaps = 7/456 (1%)
Frame = +1
Query: 91 LEAVDPEIHDLIEKEKRRQCRGIELIASENFTSFAVIEALGSALTNKYSEGMPGNRYYGG 270
L+ D E++ +I+KE RQ G+ELIASENF S AV+EALGS+L NKYSEG PG RYYGG
Sbjct: 20 LKDSDAEVYSIIKKESNRQRVGLELIASENFASRAVLEALGSSLNNKYSEGYPGQRYYGG 79
Query: 271 NEYIDQIENLCRSRALQAFHLDASQWGVNVQPYSGSPANFAAYTAVLQPHDRIMGLDLPS 450
E+ID++E LC+ RALQA+HLD WGVNVQPYSGSPANFA YTA+++PH RIMGLDLP
Sbjct: 80 TEFIDELEMLCQKRALQAYHLDPQCWGVNVQPYSGSPANFAVYTALVEPHGRIMGLDLPD 139
Query: 451 GGHLTHGYYTSGGKKISATSIYFESLPYKVNSSTGYIDYDKLEEKALDFRPRLIICGGSA 630
GGHLTHG+ T KKISATSI+FES+PYKV TGYI+YD+LEE A F P+LII G S
Sbjct: 140 GGHLTHGFMTD-KKKISATSIFFESMPYKVYPETGYINYDQLEENASLFHPKLIIAGTSC 198
Query: 631 YPRDWDYARFRAVADKCGALLLCDMAHISGLVCAQEAANPFEFCDIVTTTTHKSLRGPRA 810
Y R+ DYAR R +AD GA L+ DMAHISGLV A +PFE C +VTTTTHK+LRG RA
Sbjct: 199 YSRNLDYARLRKIADDNGAYLMADMAHISGLVAAGVVPSPFEHCHVVTTTTHKTLRGCRA 258
Query: 811 GMIFYRXXXXXXXXXXXEGAEYDFEDKINFAVFPSLQGGPHNHQIGALAVALKQAMTPGF 990
GMIFYR + Y+ E IN AVFP LQGGPHNH I +AVALKQAMT F
Sbjct: 259 GMIFYRKGVRSVDPKTGKETYYELESLINSAVFPGLQGGPHNHAIAGVAVALKQAMTTEF 318
Query: 991 KAYAQQVKANAVALGKYLMSKDYKLVTGGTENHLVLWDLRPLGLTGNKVEKLCDLANITV 1170
K Y QV AN AL L YK+VTGG++NHL+L DLR G G + EK+ + +I
Sbjct: 319 KIYQLQVLANCRALSDALTELGYKIVTGGSDNHLILMDLRSKGTDGGRAEKVLEACSIAC 378
Query: 1171 NKNAVFGDSSALAPGGVRIGAPAMTSRGLVEKDFEKIGEFLHRAVTLTLKIQKEFG--KL 1344
NKN GD SAL P G+R+G PA+TSRGL+E+DF+K+ F+HR + LTL+IQ
Sbjct: 379 NKNTCPGDKSALRPSGLRLGTPALTSRGLLEEDFQKVAHFIHRGIELTLQIQSHMATKAT 438
Query: 1345 LKDFNKGLVNNKEIEE----LKADVEKFSASFDMPG 1440
LK+F + L +++I+ L+ +VE F+++F +PG
Sbjct: 439 LKEFKEKLAGDEKIQSAVATLREEVENFASNFSLPG 474
>sp|Q10104|GLYC_SCHPO Probable serine hydroxymethyltransferase, cytosolic
OS=Schizosaccharomyces pombe GN=shm2 PE=2 SV=1
Length = 472
Score = 490 bits (1259), Expect = 2e-137
Identities = 255/457 (55%), Positives = 313/457 (68%), Gaps = 11/457 (2%)
Frame = +1
Query: 91 LEAVDPEIHDLIEKEKRRQCRGIELIASENFTSFAVIEALGSALTNKYSEGMPGNRYYGG 270
L DP ++ ++E EK RQ I LIASENFTS AV++ALGS + NKYSEG PG RYYGG
Sbjct: 18 LAECDPTVYKILESEKSRQKESIALIASENFTSRAVMDALGSIMQNKYSEGYPGARYYGG 77
Query: 271 NEYIDQIENLCRSRALQAFHLDASQWGVNVQPYSGSPANFAAYTAVLQPHDRIMGLDLPS 450
NE+IDQ E LC++RAL+AFHLD +WGVNVQP+SGSPAN AY AV++PHDR+MGLDLP
Sbjct: 78 NEFIDQAERLCQTRALEAFHLDGEKWGVNVQPHSGSPANLQAYQAVMKPHDRLMGLDLPH 137
Query: 451 GGHLTHGYYTSGGKKISATSIYFESLPYKVNSSTGYIDYDKLEEKALDFRPRLIICGGSA 630
GGHL+HG+ T K ISA S YF ++PY VN TG IDYD LE+ A+ FRP++I+ G SA
Sbjct: 138 GGHLSHGFSTP-QKAISAVSTYFSTMPYNVNKETGIIDYDSLEKAAIQFRPKVIVAGASA 196
Query: 631 YPRDWDYARFRAVADKCGALLLCDMAHISGLVCAQEAANPFEFCDIVTTTTHKSLRGPRA 810
Y R DY R R + + C A LLCDMAHISGLV A +PFE+ DIVTTTTHKSLRGPR
Sbjct: 197 YARLVDYKRMRKITEMCNAYLLCDMAHISGLVAAGVIPSPFEYADIVTTTTHKSLRGPRG 256
Query: 811 GMIFYRXXXXXXXXXXXEGAEYDFEDKINFAVFPSLQGGPHNHQIGALAVALKQAMTPGF 990
MIFYR Y+ EDKINF+VFP QGGPHNH I ALAVAL QA TP F
Sbjct: 257 AMIFYR-KGTRSHDKRGNPILYELEDKINFSVFPGHQGGPHNHTITALAVALGQAKTPEF 315
Query: 991 KAYAQQVKANAVALGKYLMSKDYKLVTGGTENHLVLWDLRPLGLTGNKVEKLCDLANITV 1170
Y + V +NA A+ +++ YKLV+GGT+ HLVL DL G+ G +VE++ +L NI+
Sbjct: 316 YQYQKDVLSNAKAMANAFITRGYKLVSGGTDTHLVLVDLTDKGVDGARVERILELVNISA 375
Query: 1171 NKNAVFGDSSALAPGGVRIGAPAMTSRGLVEKDFEKIGEFLHRAVTLTLKIQ----KEFG 1338
NKN V GD SAL P G+R+G PA T+RG EKDFE++ E + V+LT KI KE
Sbjct: 376 NKNTVPGDKSALIPRGLRLGTPACTTRGFDEKDFERVVELIDEVVSLTKKINEAALKEGK 435
Query: 1339 KLLKDFNKGLVNN----KEIEELKADVEKFSASFDMP 1437
+DF K V + EI +LK +V ++ FD P
Sbjct: 436 SKFRDF-KAYVGDGSKFSEIAKLKKEVITWAGKFDFP 471
>sp|P34898|GLYC_NEUCR Serine hydroxymethyltransferase, cytosolic OS=Neurospora
crassa GN=for PE=3 SV=2
Length = 480
Score = 486 bits (1251), Expect = 2e-136
Identities = 253/450 (56%), Positives = 315/450 (70%), Gaps = 6/450 (1%)
Frame = +1
Query: 103 DPEIHDLIEKEKRRQCRGIELIASENFTSFAVIEALGSALTNKYSEGMPGNRYYGGNEYI 282
DP++ ++++KE +RQ I LIASEN TS AV +ALGS ++NKYSEG+PG RYYGGN++I
Sbjct: 22 DPQVAEIMKKEVQRQRESIILIASENVTSRAVFDALGSPMSNKYSEGLPGARYYGGNQHI 81
Query: 283 DQIENLCRSRALQAFHLDASQWGVNVQPYSGSPANFAAYTAVLQPHDRIMGLDLPSGGHL 462
D+IE LC++RAL+AFHLD QWGVNVQ SGSPAN Y A++ H R+MGLDLP GGHL
Sbjct: 82 DEIEVLCQNRALEAFHLDPKQWGVNVQCLSGSPANLQVYQAIMPVHGRLMGLDLPHGGHL 141
Query: 463 THGYYTSGGKKISATSIYFESLPYKVNSSTGYIDYDKLEEKALDFRPRLIICGGSAYPRD 642
+HGY T +KISA S YFE++PY+VN TG IDYD LE+ A FRP++++ G SAY R
Sbjct: 142 SHGYQTP-QRKISAVSTYFETMPYRVNIDTGLIDYDTLEKNAQLFRPKVLVAGTSAYCRL 200
Query: 643 WDYARFRAVADKCGALLLCDMAHISGLVCAQEAANPFEFCDIVTTTTHKSLRGPRAGMIF 822
DY R R +AD GA L+ DMAHISGL+ ++ +PF + D+VTTTTHKSLRGPR MIF
Sbjct: 201 IDYERMRKIADSVGAYLVVDMAHISGLIASEVIPSPFLYADVVTTTTHKSLRGPRGAMIF 260
Query: 823 YRXXXXXXXXXXXEGAEYDFEDKINFAVFPSLQGGPHNHQIGALAVALKQAMTPGFKAYA 1002
+R + YD EDKINF+VFP QGGPHNH I ALAVALKQA +P FK Y
Sbjct: 261 FRRGVRSVDAKTGKETLYDLEDKINFSVFPGHQGGPHNHTITALAVALKQAASPEFKEYQ 320
Query: 1003 QQVKANAVALGKYLMSKDYKLVTGGTENHLVLWDLRPLGLTGNKVEKLCDLANITVNKNA 1182
Q+V ANA AL K L YKLV+ GT++H+VL DLRP+G+ G +VE L + NIT NKNA
Sbjct: 321 QKVVANAKALEKKLKELGYKLVSDGTDSHMVLVDLRPIGVDGARVEFLLEQINITCNKNA 380
Query: 1183 VFGDSSALAPGGVRIGAPAMTSRGLVEKDFEKIGEFLHRAVTLTLKIQKEFGK---LLKD 1353
V GD SAL PGG+RIG PAMTSRG E DFEK+ F+ AV L +IQ K KD
Sbjct: 381 VPGDKSALTPGGLRIGTPAMTSRGFGEADFEKVAVFVDEAVKLCKEIQASLPKEANKQKD 440
Query: 1354 FNKGLVNN--KEIEELKADVEKFSASFDMP 1437
F + + I ELK ++ +S +F +P
Sbjct: 441 FKAKIATSDIPRINELKQEIAAWSNTFPLP 470
>sp|Q6CLQ5|GLYM_KLULA Serine hydroxymethyltransferase, mitochondrial
OS=Kluyveromyces lactis GN=SHM1 PE=3 SV=1
Length = 498
Score = 464 bits (1192), Expect = 1e-129
Identities = 233/458 (50%), Positives = 311/458 (67%), Gaps = 8/458 (1%)
Frame = +1
Query: 88 NLEAVDPEIHDLIEKEKRRQCRGIELIASENFTSFAVIEALGSALTNKYSEGMPGNRYYG 267
+++ +DPE++D++ KE++RQ I LI SENFTS +V++ LGS + NKYSEG PG RYYG
Sbjct: 40 HVQDIDPEMYDILTKERKRQKHSITLIPSENFTSKSVMDLLGSEMQNKYSEGYPGERYYG 99
Query: 268 GNEYIDQIENLCRSRALQAFHLDASQWGVNVQPYSGSPANFAAYTAVLQPHDRIMGLDLP 447
GN++ID E+LC+ RAL+ ++LD WGVNVQP SG+PAN AY+AV++ +DR+MGLDLP
Sbjct: 100 GNQFIDMAESLCQKRALELYNLDPQLWGVNVQPLSGAPANLYAYSAVMETNDRLMGLDLP 159
Query: 448 SGGHLTHGYYTSGGKKISATSIYFESLPYKVNSSTGYIDYDKLEEKALDFRPRLIICGGS 627
GGHL+HGY G KIS S YF+++PY V+S TG IDYD L + + FRP++I+ G S
Sbjct: 160 HGGHLSHGYQLPSGTKISYISKYFQTMPYHVDSQTGIIDYDFLSKTSKLFRPKVIVAGAS 219
Query: 628 AYPRDWDYARFRAVADKCGALLLCDMAHISGLVCAQEAANPFEFCDIVTTTTHKSLRGPR 807
AY R DY RF+ +AD CGA L+ DMAHISGLV A +PFE+ DIVTTTTHKSLRGPR
Sbjct: 220 AYSRVLDYKRFKEIADACGAYLMSDMAHISGLVAAGVTRSPFEYSDIVTTTTHKSLRGPR 279
Query: 808 AGMIFYRXXXXXXXXXXXEGAEYDFEDKINFAVFPSLQGGPHNHQIGALAVALKQAMTPG 987
MIFYR E YD + +INF+VFP QGGPHNH I ALAVALKQA TP
Sbjct: 280 GAMIFYRKGVRKVTKKGKE-VLYDLDKRINFSVFPGHQGGPHNHTISALAVALKQAATPE 338
Query: 988 FKAYAQQVKANAVALGKYLMSKDYKLVTGGTENHLVLWDLRPLGLTGNKVEKLCDLANIT 1167
FK Y V NA G+ L+ K ++LV+GGT+ HL+L +L LG+ G ++E L + NI
Sbjct: 339 FKEYQAAVVENARIFGEELVKKGFELVSGGTDTHLILINLSNLGIDGARLETLLENINIA 398
Query: 1168 VNKNAVFGDSSALAPGGVRIGAPAMTSRGLVEKDFEKIGEFLHRAVTLTLKIQKEFGKLL 1347
NKN + GD SAL P G+R+G PAMT+RG ++F ++ ++ RAV L + I+ +
Sbjct: 399 ANKNTIPGDKSALFPSGLRVGTPAMTTRGFGPQEFAQVAAYIDRAVKLAIGIKSQESPDA 458
Query: 1348 KDFNKGLVNNKE-------IEELKADVEKFSASFDMPG 1440
KD L + KE +++L +V ++ F +PG
Sbjct: 459 KDARSKLASFKELCKESDQVKQLADEVYQWVGEFPVPG 496
>sp|Q6FQ44|GLYM_CANGA Serine hydroxymethyltransferase, mitochondrial OS=Candida
glabrata GN=SHM1 PE=3 SV=1
Length = 485
Score = 463 bits (1191), Expect = 2e-129
Identities = 232/458 (50%), Positives = 309/458 (67%), Gaps = 7/458 (1%)
Frame = +1
Query: 88 NLEAVDPEIHDLIEKEKRRQCRGIELIASENFTSFAVIEALGSALTNKYSEGMPGNRYYG 267
+++ VDPE+ ++ E+ RQ + LI SENFTS AV++ LGS + NKYSEG PG RYYG
Sbjct: 26 HVQEVDPEMFRILSDERSRQKHSVTLIPSENFTSKAVMDLLGSEMQNKYSEGYPGERYYG 85
Query: 268 GNEYIDQIENLCRSRALQAFHLDASQWGVNVQPYSGSPANFAAYTAVLQPHDRIMGLDLP 447
GN++ID+ E+LC++RAL + LD +WGVNVQ SG+PAN AY+AV++ DR+MGLDLP
Sbjct: 86 GNQFIDKAESLCQARALDLYGLDPEKWGVNVQALSGAPANLYAYSAVMEVGDRLMGLDLP 145
Query: 448 SGGHLTHGYYTSGGKKISATSIYFESLPYKVNSSTGYIDYDKLEEKALDFRPRLIICGGS 627
GGHL+HGY G KIS S YF ++PY VN+ TG IDYD L + FRP++I+ G S
Sbjct: 146 HGGHLSHGYQLPSGTKISYISKYFNTMPYHVNTETGIIDYDTLAMTSKLFRPKVIVAGTS 205
Query: 628 AYPRDWDYARFRAVADKCGALLLCDMAHISGLVCAQEAANPFEFCDIVTTTTHKSLRGPR 807
AY R DYARFR +AD CGA LL DMAHISGLV A +PFE DIVTTTTHKSLRGPR
Sbjct: 206 AYSRKLDYARFRKIADGCGAYLLSDMAHISGLVAANVIDSPFEHSDIVTTTTHKSLRGPR 265
Query: 808 AGMIFYRXXXXXXXXXXXEGAEYDFEDKINFAVFPSLQGGPHNHQIGALAVALKQAMTPG 987
MIFYR + + F+ INF+VFP QGGPHNH I ALAVALKQA TP
Sbjct: 266 GAMIFYRKGIKKVNKKTGKETPFTFDKTINFSVFPGHQGGPHNHTISALAVALKQAKTPE 325
Query: 988 FKAYAQQVKANAVALGKYLMSKDYKLVTGGTENHLVLWDLRPLGLTGNKVEKLCDLANIT 1167
F Y +QV +NA A G L+ + ++LV+GGT+NHL+L +L +G+ G ++E + + NI
Sbjct: 326 FVEYQKQVVSNAKAFGDELLKRGFELVSGGTDNHLLLLNLSNMGIDGARLEAILEKINIA 385
Query: 1168 VNKNAVFGDSSALAPGGVRIGAPAMTSRGLVEKDFEKIGEFLHRAVTLTLKIQKEFGKLL 1347
NKN + GD SAL P G+R+G PAMT+RG E+DF+K+ E++ AV L++ ++ +
Sbjct: 386 ANKNTIPGDKSALFPSGLRVGTPAMTTRGFQEQDFKKVAEYIDNAVKLSIALKSQESADA 445
Query: 1348 KDFNKGLVNNKE-------IEELKADVEKFSASFDMPG 1440
KD L + K+ +++L +V + +F +PG
Sbjct: 446 KDVRSKLNSFKQLCDQSEPVQKLAEEVSSWVGTFPVPG 483
>sp|Q75BQ6|GLYC_ASHGO Serine hydroxymethyltransferase, cytosolic OS=Ashbya
gossypii GN=SHM2 PE=3 SV=1
Length = 469
Score = 461 bits (1186), Expect = 6e-129
Identities = 239/456 (52%), Positives = 309/456 (67%), Gaps = 5/456 (1%)
Frame = +1
Query: 82 NTNLEAVDPEIHDLIEKEKRRQCRGIELIASENFTSFAVIEALGSALTNKYSEGMPGNRY 261
+++L DPE+ +I+ E RQ I LIASEN TS AV +ALG+ + NKYSEG PG RY
Sbjct: 14 SSHLSESDPEVDAIIKDEIDRQKHSIVLIASENLTSTAVFDALGTPMCNKYSEGYPGARY 73
Query: 262 YGGNEYIDQIENLCRSRALQAFHLDASQWGVNVQPYSGSPANFAAYTAVLQPHDRIMGLD 441
YGGN++ID++E LC+ RAL+AFH+ +WGVNVQ SGSPAN Y A+++PH+R+MGL
Sbjct: 74 YGGNQHIDRMELLCQRRALEAFHVTPDRWGVNVQSLSGSPANLQVYQALMKPHERLMGLH 133
Query: 442 LPSGGHLTHGYYTSGGKKISATSIYFESLPYKVNSSTGYIDYDKLEEKALDFRPRLIICG 621
LP GGHL+HGY T +KISA S YFES PY+V+ TG IDYD LE+ A+ +RP++++ G
Sbjct: 134 LPDGGHLSHGYQTE-TRKISAVSTYFESFPYRVDPETGIIDYDTLEKNAVLYRPKILVAG 192
Query: 622 GSAYPRDWDYARFRAVADKCGALLLCDMAHISGLVCAQEAANPFEFCDIVTTTTHKSLRG 801
SAY R DY R R +ADK GA L+ DMAHISGLV A +PFE+ DIVTTTTHKSLRG
Sbjct: 193 TSAYCRLIDYKRMREIADKVGAYLMVDMAHISGLVAAGVIPSPFEYADIVTTTTHKSLRG 252
Query: 802 PRAGMIFYRXXXXXXXXXXXEGAEYDFEDKINFAVFPSLQGGPHNHQIGALAVALKQAMT 981
PR MIF+R E YD E INF+VFP QGGPHNH I ALA ALKQA T
Sbjct: 253 PRGAMIFFRRGVRSVHPKTGEEVMYDLEGPINFSVFPGHQGGPHNHTISALATALKQATT 312
Query: 982 PGFKAYAQQVKANAVALGKYLMSKDYKLVTGGTENHLVLWDLRPLGLTGNKVEKLCDLAN 1161
P F+ Y + V NA L +Y+LV+ GT++H+VL LR G+ G +VE +C+ N
Sbjct: 313 PEFREYQELVLKNAKVLETEFKKLNYRLVSDGTDSHMVLVSLREKGVDGARVEHVCEKIN 372
Query: 1162 ITVNKNAVFGDSSALAPGGVRIGAPAMTSRGLVEKDFEKIGEFLHRAVTLTLKIQKEFGK 1341
I +NKN++ GD SAL PGGVRIGAPAMT+RG+ E+DF +I +++RAV + IQ+ K
Sbjct: 373 IALNKNSIPGDKSALVPGGVRIGAPAMTTRGMGEEDFARIVGYINRAVEIARSIQQSLPK 432
Query: 1342 ---LLKDFN-KGLVNNKEIEELKADVEKFSASFDMP 1437
LKDF K EI +L ++ ++ + +P
Sbjct: 433 EANRLKDFKAKVEGGTDEIAQLAQEIYSWTEEYPLP 468
>sp|Q758F0|GLYM_ASHGO Serine hydroxymethyltransferase, mitochondrial OS=Ashbya
gossypii GN=SHM1 PE=3 SV=1
Length = 497
Score = 458 bits (1178), Expect = 5e-128
Identities = 228/458 (49%), Positives = 307/458 (67%), Gaps = 8/458 (1%)
Frame = +1
Query: 88 NLEAVDPEIHDLIEKEKRRQCRGIELIASENFTSFAVIEALGSALTNKYSEGMPGNRYYG 267
+++ DPE++D++ KE+ RQ R I LI SENFTS AV+ LGS + NKYSEG PG RYYG
Sbjct: 39 HVQEFDPEMYDILTKERSRQKRSITLIPSENFTSVAVMNLLGSEMQNKYSEGYPGQRYYG 98
Query: 268 GNEYIDQIENLCRSRALQAFHLDASQWGVNVQPYSGSPANFAAYTAVLQPHDRIMGLDLP 447
GN+YID E+LC+ RAL+ + LD ++WGVNVQ SG+PAN AY+A+++ DR+MGLDLP
Sbjct: 99 GNQYIDMAESLCQKRALELYGLDPAKWGVNVQSLSGAPANLYAYSAIMEVGDRMMGLDLP 158
Query: 448 SGGHLTHGYYTSGGKKISATSIYFESLPYKVNSSTGYIDYDKLEEKALDFRPRLIICGGS 627
GGHL+HGY G KIS S YF+++ Y+V+ +TG +DYD L E + FRP++I+ G S
Sbjct: 159 HGGHLSHGYQLQNGNKISYISKYFQTMAYRVDPATGLVDYDTLSETSKLFRPKVIVAGTS 218
Query: 628 AYPRDWDYARFRAVADKCGALLLCDMAHISGLVCAQEAANPFEFCDIVTTTTHKSLRGPR 807
AY R DY RFR +AD CGA LL DMAH+SGLV A +PFE+ DIVTTTTHKSLRGPR
Sbjct: 219 AYARVLDYKRFREIADACGAYLLSDMAHVSGLVAAGVHPSPFEYSDIVTTTTHKSLRGPR 278
Query: 808 AGMIFYRXXXXXXXXXXXEGAEYDFEDKINFAVFPSLQGGPHNHQIGALAVALKQAMTPG 987
MIFYR E YD + +INF+VFP+ QGGPHNH I ALAVALKQA TP
Sbjct: 279 GAMIFYRKGIRKVTKKGTE-IMYDLDKRINFSVFPAHQGGPHNHTISALAVALKQAATPE 337
Query: 988 FKAYAQQVKANAVALGKYLMSKDYKLVTGGTENHLVLWDLRPLGLTGNKVEKLCDLANIT 1167
FK Y V NA G+ L + + LV+GGT+ HL+L DL P+G+ G+++E + + NI
Sbjct: 338 FKNYQTAVVENAKVFGEELSKRGFSLVSGGTDTHLLLIDLSPMGIDGSRLETILERLNIA 397
Query: 1168 VNKNAVFGDSSALAPGGVRIGAPAMTSRGLVEKDFEKIGEFLHRAVTLTLKIQ------- 1326
NKN + GD SAL P G+R+G PAMT+RG +F ++ +++ AV L + ++
Sbjct: 398 ANKNTIPGDKSALYPSGLRVGTPAMTTRGFGPAEFGRVAAYINEAVKLAIGLKSQEPVDA 457
Query: 1327 KEFGKLLKDFNKGLVNNKEIEELKADVEKFSASFDMPG 1440
K+ L F ++++ +L +V + A + +PG
Sbjct: 458 KDAKTRLAHFKSFCAESEQVTKLANEVADWVAQYPVPG 495
>sp|O13425|GLYM_CANAL Serine hydroxymethyltransferase, mitochondrial OS=Candida
albicans GN=SHM1 PE=3 SV=1
Length = 493
Score = 454 bits (1166), Expect = 1e-126
Identities = 238/456 (52%), Positives = 310/456 (67%), Gaps = 7/456 (1%)
Frame = +1
Query: 88 NLEAVDPEIHDLIEKEKRRQCRGIELIASENFTSFAVIEALGSALTNKYSEGMPGNRYYG 267
+++ VDPE+ D++ +E+ RQ I LI SENFTS AV++ LGS + NKYSEG PG RYYG
Sbjct: 38 SVQDVDPEMADILNQERTRQKNSITLIPSENFTSKAVMDLLGSEMQNKYSEGYPGERYYG 97
Query: 268 GNEYIDQIENLCRSRALQAFHLDASQWGVNVQPYSGSPANFAAYTAVLQPHDRIMGLDLP 447
GNE ID+ E LC+ RAL+AF LD SQWGVNVQP SG+PAN AY+A+L+ DRIMGLDLP
Sbjct: 98 GNEIIDKAEALCQKRALEAFGLDPSQWGVNVQPLSGAPANLYAYSAILEVGDRIMGLDLP 157
Query: 448 SGGHLTHGYYTSGGKKISATSIYFESLPYKVNSSTGYIDYDKLEEKALDFRPRLIICGGS 627
GGHL+HGY T KIS S YF+++PY++N TG IDYD LE+ A FRP++I+ G S
Sbjct: 158 HGGHLSHGYQTK-TTKISYISKYFQTMPYRLNEETGIIDYDTLEKNAQLFRPKVIVAGAS 216
Query: 628 AYPRDWDYARFRAVADKCGALLLCDMAHISGLVCAQEAANPFEFCDIVTTTTHKSLRGPR 807
AY R DY R R ++ + GA LL DMAHISGLV A +PF + DIVTTTTHKSLRGPR
Sbjct: 217 AYSRVIDYKRMRQLSIRLGAYLLSDMAHISGLVSAVVTDSPFPYSDIVTTTTHKSLRGPR 276
Query: 808 AGMIFYRXXXXXXXXXXXEGAEYDFEDKINFAVFPSLQGGPHNHQIGALAVALKQAMTPG 987
MIF+R E Y+ E KINF VFP QGGPHNH I ALAVALKQ P
Sbjct: 277 GAMIFFRKGIRKVTTKGKE-IPYELERKINFLVFPGHQGGPHNHTISALAVALKQCTEPE 335
Query: 988 FKAYAQQVKANAVALGKYLMSKDYKLVTGGTENHLVLWDLRPLGLTGNKVEKLCDLANIT 1167
+ Y Q+V +NA L+SK +KLV+ GT+ HL+L DLR + G +VE + + ANI
Sbjct: 336 YVKYQQEVVSNAKHFADALVSKGFKLVSDGTDTHLILVDLRSRNIDGARVEAVLERANIA 395
Query: 1168 VNKNAVFGDSSALAPGGVRIGAPAMTSRGLVEKDFEKIGEFLHRAVTLTLKIQ-KEFGK- 1341
NKN V GD SAL P G+R+G PAMT+RG ++F+K+ EF+ +AV + ++++ +E GK
Sbjct: 396 ANKNTVPGDVSALFPSGLRVGTPAMTTRGFGPEEFDKVAEFIDQAVNIAIELKAQEQGKV 455
Query: 1342 ---LLKDFNKGLVNNKEIEELKADVEKFSASFDMPG 1440
LL F K + ++++L +V + + + +PG
Sbjct: 456 PKELLASFKKLADESDKVKQLDKEVVSWVSKYPVPG 491
>sp|P37292|GLYM_YEAST Serine hydroxymethyltransferase, mitochondrial
OS=Saccharomyces cerevisiae GN=SHM1 PE=1 SV=2
Length = 490
Score = 450 bits (1156), Expect = 2e-125
Identities = 230/453 (50%), Positives = 301/453 (66%), Gaps = 8/453 (1%)
Frame = +1
Query: 103 DPEIHDLIEKEKRRQCRGIELIASENFTSFAVIEALGSALTNKYSEGMPGNRYYGGNEYI 282
DPE+ D++++E+ RQ I LI SENFTS AV++ LGS L NKYSEG PG RYYGGNE I
Sbjct: 37 DPEMFDILQQERHRQKHSITLIPSENFTSKAVMDLLGSELQNKYSEGYPGERYYGGNEII 96
Query: 283 DQIENLCRSRALQAFHLDASQWGVNVQPYSGSPANFAAYTAVLQPHDRIMGLDLPSGGHL 462
D+ E+LC++RAL+ + LD ++WGVNVQP SG+PAN Y+A++ +R+MGLDLP GGHL
Sbjct: 97 DKSESLCQARALELYGLDPAKWGVNVQPLSGAPANLYVYSAIMNVGERLMGLDLPDGGHL 156
Query: 463 THGYYTSGGKKISATSIYFESLPYKVNSSTGYIDYDKLEEKALDFRPRLIICGGSAYPRD 642
+HGY G IS S YF+S+PY V+ +TG IDYD L+ A FRP++I+ G SAY R
Sbjct: 157 SHGYQLKSGTPISFISKYFQSMPYHVDHTTGLIDYDNLQVLAKAFRPKVIVAGTSAYSRL 216
Query: 643 WDYARFRAVADKCGALLLCDMAHISGLVCAQEAANPFEFCDIVTTTTHKSLRGPRAGMIF 822
DYARF+ ++ CGA L+ DMAHISGLV A +PFE DIVTTTTHKSLRGPR MIF
Sbjct: 217 IDYARFKEISQGCGAYLMSDMAHISGLVAANVVPSPFEHSDIVTTTTHKSLRGPRGAMIF 276
Query: 823 YRXXXXXXXXXXXEGAEYDFEDKINFAVFPSLQGGPHNHQIGALAVALKQAMTPGFKAYA 1002
+R E Y+ E KINF+VFP QGGPHNH IGA+AVALKQAM+P FK Y
Sbjct: 277 FRKGIKSVTKKGKE-IPYELEKKINFSVFPGHQGGPHNHTIGAMAVALKQAMSPEFKEYQ 335
Query: 1003 QQVKANAVALGKYLMSKDYKLVTGGTENHLVLWDLRPLGLTGNKVEKLCDLANITVNKNA 1182
Q++ N+ + L YKLV+GGT+NHL++ DL + G +VE + NI NKN
Sbjct: 336 QKIVDNSKWFAQELTKMGYKLVSGGTDNHLIVIDLSGTQVDGARVETILSALNIAANKNT 395
Query: 1183 VFGDSSALAPGGVRIGAPAMTSRGLVEKDFEKIGEFLHRAVTL--TLKIQKEFGKL---- 1344
+ GD SAL P G+RIG PAMT+RG ++F ++ +++ AV L LK + KL
Sbjct: 396 IPGDKSALFPSGLRIGTPAMTTRGFGREEFSQVAKYIDSAVKLAENLKTLEPTTKLDARS 455
Query: 1345 -LKDFNKGLVNNKEIEELKADVEKFSASFDMPG 1440
L +F K + E+ L ++ K+ + +PG
Sbjct: 456 RLNEFKKLCNESSEVAALSGEISKWVGQYPVPG 488
Database: UniProt/Swiss-Prot
Posted date: Thu Apr 23 14:22:33 2009
Number of letters in database: 163,773,382
Number of sequences in database: 462,764
Lambda K H
0.267 0.041 0.140
Gapped
Lambda K H
0.267 0.041 0.140
Matrix: blosum62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 8,735,772,867
Number of Sequences: 462764
Number of Extensions: 8735772867
Number of Successful Extensions: 83663288
Number of sequences better than 0.0: 0
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